2022
- Mak, JKL, Eriksdotter, M, Annetorp, M, Kuja-Halkola, R, Kananen, L, Boström, AM et al.. Two Years with COVID-19: The Electronic Frailty Index Identifies High-Risk Patients in the Stockholm GeroCovid Study. Gerontology. 2023;69 (4):396-405. doi: 10.1159/000527206. PubMed PMID:36450240 PubMed Central PMC9747746.
- Marttila, S, Tamminen, H, Rajić, S, Mishra, PP, Lehtimäki, T, Raitakari, O et al.. Methylation status of / is stable across populations, monozygotic twin pairs and in majority of tissues. Epigenomics. 2022;14 (18):1105-1124. doi: 10.2217/epi-2022-0228. PubMed PMID:36200237 .
- Karlsson, IK, Zhan, Y, Wang, Y, Li, X, Jylhävä, J, Hägg, S et al.. Adiposity and the risk of dementia: mediating effects from inflammation and lipid levels. Eur J Epidemiol. 2022;37 (12):1261-1271. doi: 10.1007/s10654-022-00918-w. PubMed PMID:36192662 PubMed Central PMC9792412.
- Kananen, L, Hurme, M, Bürkle, A, Moreno-Villanueva, M, Bernhardt, J, Debacq-Chainiaux, F et al.. Circulating cell-free DNA in health and disease – the relationship to health behaviours, ageing phenotypes and metabolomics. Geroscience. 2023;45 (1):85-103. doi: 10.1007/s11357-022-00590-8. PubMed PMID:35864375 PubMed Central PMC9886738.
- Levin, AT, Jylhävä, J, Religa, D, Shallcross, L. COVID-19 prevalence and mortality in longer-term care facilities. Eur J Epidemiol. 2022;37 (3):227-234. doi: 10.1007/s10654-022-00861-w. PubMed PMID:35397704 PubMed Central PMC8994824.
- Mak, JKL, Hägg, S, Eriksdotter, M, Annetorp, M, Kuja-Halkola, R, Kananen, L et al.. Development of an Electronic Frailty Index for Hospitalized Older Adults in Sweden. J Gerontol A Biol Sci Med Sci. 2022;77 (11):2311-2319. doi: 10.1093/gerona/glac069. PubMed PMID:35303746 PubMed Central PMC9678204.
- Meoni, G, Tenori, L, Schade, S, Licari, C, Pirazzini, C, Bacalini, MG et al.. Metabolite and lipoprotein profiles reveal sex-related oxidative stress imbalance in de novo drug-naive Parkinson’s disease patients. NPJ Parkinsons Dis. 2022;8 (1):14. doi: 10.1038/s41531-021-00274-8. PubMed PMID:35136088 PubMed Central PMC8826921.
- Zago, E, Dal Molin, A, Dimitri, GM, Xumerle, L, Pirazzini, C, Bacalini, MG et al.. Early downregulation of hsa-miR-144-3p in serum from drug-naïve Parkinson’s disease patients. Sci Rep. 2022;12 (1):1330. doi: 10.1038/s41598-022-05227-6. PubMed PMID:35079043 PubMed Central PMC8789812.
- Haapanen, MJ, Jylhävä, J, Kortelainen, L, Mikkola, TM, Salonen, M, Wasenius, NS et al.. Early-Life Factors as Predictors of Age-Associated Deficit Accumulation Across 17 Years From Midlife Into Old Age. J Gerontol A Biol Sci Med Sci. 2022;77 (11):2281-2287. doi: 10.1093/gerona/glac007. PubMed PMID:35018457 PubMed Central PMC9678199.
- Kochar, B, Jylhävä, J, Söderling, J, Ritchie, CS, SWIBREG Study Group, Ludvigsson, JF et al.. Prevalence and Implications of Frailty in Older Adults With Incident Inflammatory Bowel Diseases: A Nationwide Cohort Study. Clin Gastroenterol Hepatol. 2022;20 (10):2358-2365.e11. doi: 10.1016/j.cgh.2022.01.001. PubMed PMID:34999206 PubMed Central PMC9294971.
- Tomata, Y, Wang, Y, Hägg, S, Jylhävä, J. Protein Nutritional Status and Frailty: A Mendelian Randomization Study. J Nutr. 2022;152 (1):269-275. doi: 10.1093/jn/nxab348. PubMed PMID:34601600 PubMed Central PMC8754580.
2021
- Wennberg, AM, Yin, W, Fang, F, Pedersen, NL, Hägg, S, Jylhävä, J et al.. Comparison of two different frailty scales in the longitudinal Swedish Adoption/Twin Study of Aging (SATSA). Scand J Public Health. 2023;51 (4):587-594. doi: 10.1177/14034948211059958. PubMed PMID:34904462PubMed Central PMC10265292.
- Tomata, Y, Wang, Y, Hägg, S, Jylhävä, J. Fatty Acids and Frailty: A Mendelian Randomization Study. Nutrients. 2021;13 (10):. doi: 10.3390/nu13103539. PubMed PMID:34684540 PubMed Central PMC8541183.
- Bai, G, Wang, Y, Kuja-Halkola, R, Li, X, Tomata, Y, Karlsson, IK et al.. Frailty and the risk of dementia: is the association explained by shared environmental and genetic factors?. BMC Med. 2021;19 (1):248. doi: 10.1186/s12916-021-02104-3. PubMed PMID:34657626 PubMed Central PMC8522144.
- Baldelli, L, Schade, S, Jesús, S, Schreglmann, SR, Sambati, L, Gómez-Garre, P et al.. Heterogeneity of prodromal Parkinson symptoms in siblings of Parkinson disease patients. NPJ Parkinsons Dis. 2021;7 (1):78. doi: 10.1038/s41531-021-00219-1. PubMed PMID:34493736 PubMed Central PMC8423761.
- Atkins, JL, Jylhävä, J, Pedersen, NL, Magnusson, PK, Lu, Y, Wang, Y et al.. A genome-wide association study of the frailty index highlights brain pathways in ageing. Aging Cell. 2021;20 (9):e13459. doi: 10.1111/acel.13459. PubMed PMID:34431594 PubMed Central PMC8441299.
- Mak, JKL, Reynolds, CA, Hägg, S, Li, X, Ericsson, M, Pedersen, NL et al.. Sex differences in genetic and environmental influences on frailty and its relation to body mass index and education. Aging (Albany NY). 2021;13 (13):16990-17023. doi: 10.18632/aging.203262. PubMed PMID:34230219PubMed Central PMC8312411.
- Bai, G, Szwajda, A, Wang, Y, Li, X, Bower, H, Karlsson, IK et al.. Frailty trajectories in three longitudinal studies of aging: Is the level or the rate of change more predictive of mortality?. Age Ageing. 2021;50 (6):2174-2182. doi: 10.1093/ageing/afab106. PubMed PMID:34120182 PubMed Central PMC8581383.
- Hägg, S, Jylhävä, J. Sex differences in biological aging with a focus on human studies. Elife. 2021;10 :. doi: 10.7554/eLife.63425. PubMed PMID:33982659 PubMed Central PMC8118651.
- Karlsson, IK, Ericsson, M, Wang, Y, Jylhävä, J, Hägg, S, Dahl Aslan, AK et al.. Epigenome-wide association study of level and change in cognitive abilities from midlife through late life. Clin Epigenetics. 2021;13 (1):85. doi: 10.1186/s13148-021-01075-9. PubMed PMID:33883019 PubMed Central PMC8061224.
- Li, X, Ploner, A, Wang, Y, Zhan, Y, Pedersen, NL, Magnusson, PK et al.. Clinical biomarkers and associations with healthspan and lifespan: Evidence from observational and genetic data. EBioMedicine. 2021;66 :103318. doi: 10.1016/j.ebiom.2021.103318. PubMed PMID:33813140 PubMed Central PMC8047464.
- Mak, JKL, Kuja-Halkola, R, Wang, Y, Hägg, S, Jylhävä, J. Frailty and comorbidity in predicting community COVID-19 mortality in the U.K. Biobank: The effect of sampling. J Am Geriatr Soc. 2021;69 (5):1128-1139. doi: 10.1111/jgs.17089. PubMed PMID:33619733 PubMed Central PMC8013405.
- Hägg, S, Jylhävä, J, Wang, Y, Czene, K, Grassmann, F. Correction to: Deciphering the genetic and epidemiological landscape of mitochondrial DNA abundance. Hum Genet. 2021;140 (6):863. doi: 10.1007/s00439-021-02258-3. PubMed PMID:33547498 PubMed Central PMC8496643.
- van Dongen, J, Hagenbeek, FA, Suderman, M, Roetman, PJ, Sugden, K, Chiocchetti, AG et al.. DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan. Mol Psychiatry. 2021;26 (6):2148-2162. doi: 10.1038/s41380-020-00987-x. PubMed PMID:33420481 PubMed Central PMC8263810.
- Pirazzini, C, Azevedo, T, Baldelli, L, Bartoletti-Stella, A, Calandra-Buonaura, G, Dal Molin, A et al.. A geroscience approach for Parkinson’s disease: Conceptual framework and design of PROPAG-AGEING project. Mech Ageing Dev. 2021;194 :111426. doi: 10.1016/j.mad.2020.111426. PubMed PMID:33385396 .
- Hägg, S, Jylhävä, J, Wang, Y, Czene, K, Grassmann, F. Deciphering the genetic and epidemiological landscape of mitochondrial DNA abundance. Hum Genet. 2021;140 (6):849-861. doi: 10.1007/s00439-020-02249-w. PubMed PMID:33385171 PubMed Central PMC8099832.
2020
- Pirazzini, C, Azevedo, T, Baldelli, L, Bartoletti-Stella, A, Calandra-Buonaura, G, Dal Molin, A et al.. A geroscience approach for Parkinson’s disease: Conceptual framework and design of PROPAG-AGEING project. Mech Ageing Dev. 2021;194 :111426. doi: 10.1016/j.mad.2020.111426. PubMed PMID:33385396 .
- Hägg, S, Jylhävä, J, Wang, Y, Czene, K, Grassmann, F. Deciphering the genetic and epidemiological landscape of mitochondrial DNA abundance. Hum Genet. 2021;140 (6):849-861. doi: 10.1007/s00439-020-02249-w. PubMed PMID:33385171 PubMed Central PMC8099832.
- Hägg, S, Jylhävä, J, Wang, Y, Xu, H, Metzner, C, Annetorp, M et al.. Age, Frailty, and Comorbidity as Prognostic Factors for Short-Term Outcomes in Patients With Coronavirus Disease 2019 in Geriatric Care. J Am Med Dir Assoc. 2020;21 (11):1555-1559.e2. doi: 10.1016/j.jamda.2020.08.014. PubMed PMID:32978065 PubMed Central PMC7427570.
- Nyberg, A, Larsson, A, Jylhävä, J, Hurme, M, Sperber, J, Lipcsey, M et al.. Lung-protective ventilation suppresses systemic and hepatic vein levels of cell-free DNA in porcine experimental post-operative sepsis. BMC Pulm Med. 2020;20 (1):206. doi: 10.1186/s12890-020-01239-y. PubMed PMID:32736620 PubMed Central PMC7393331.
- Reynolds, CA, Tan, Q, Munoz, E, Jylhävä, J, Hjelmborg, J, Christiansen, L et al.. A decade of epigenetic change in aging twins: Genetic and environmental contributions to longitudinal DNA methylation. Aging Cell. 2020;19 (8):e13197. doi: 10.1111/acel.13197. PubMed PMID:32710526PubMed Central PMC7431820.
- Raymond, E, Reynolds, CA, Dahl Aslan, AK, Finkel, D, Ericsson, M, Hägg, S et al.. Drivers of Frailty from Adulthood into Old Age: Results from a 27-Year Longitudinal Population-Based Study in Sweden. J Gerontol A Biol Sci Med Sci. 2020;75 (10):1943-1950. doi: 10.1093/gerona/glaa106. PubMed PMID:32348465 PubMed Central PMC7518563.
- Li, X, Ploner, A, Wang, Y, Magnusson, PK, Reynolds, C, Finkel, D et al.. Longitudinal trajectories, correlations and mortality associations of nine biological ages across 20-years follow-up. Elife. 2020;9 :. doi: 10.7554/eLife.51507. PubMed PMID:32041686 PubMed Central PMC7012595.
- Karlsson, IK, Ericsson, M, Wang, Y, Jylhävä, J, Hägg, S, Pedersen, NL et al.. Replicating associations between DNA methylation and body mass index in a longitudinal sample of older twins. Int J Obes (Lond). 2020;44 (6):1397-1405. doi: 10.1038/s41366-019-0498-6. PubMed PMID:31801962 .
- Hägg, S, Jylhävä, J. Should we invest in biological age predictors to treat colorectal cancer in older adults?. Eur J Surg Oncol. 2020;46 (3):316-320. doi: 10.1016/j.ejso.2019.11.003. PubMed PMID:31761509 .
2018
- Svane, AM, Soerensen, M, Lund, J, Tan, Q, Jylhävä, J, Wang, Y et al.. DNA Methylation and All-Cause Mortality in Middle-Aged and Elderly Danish Twins. Genes (Basel). 2018;9 (2):. doi: 10.3390/genes9020078. PubMed PMID:29419728 PubMed Central PMC5852574.
2017
- Jiang, M, Foebel, AD, Kuja-Halkola, R, Karlsson, I, Pedersen, NL, Hägg, S et al.. Frailty index as a predictor of all-cause and cause-specific mortality in a Swedish population-based cohort. Aging (Albany NY). 2017;9 (12):2629-2646. doi: 10.18632/aging.101352. PubMed PMID:29273703 PubMed Central PMC5764396.
- Marttila, S, Nevalainen, T, Jylhävä, J, Kananen, L, Jylhä, M, Hervonen, A et al.. Human endogenous retrovirus HERV-K(HML-2) env expression is not associated with markers of immunosenescence. Exp Gerontol. 2017;97 :60-63. doi: 10.1016/j.exger.2017.07.019. PubMed PMID:28774724 .
- Jylhävä, J, Pedersen, NL, Hägg, S. Biological Age Predictors. EBioMedicine. 2017;21 :29-36. doi: 10.1016/j.ebiom.2017.03.046. PubMed PMID:28396265 PubMed Central PMC5514388.
- Lisko, I, Tiainen, K, Raitanen, J, Jylhävä, J, Hurme, M, Hervonen, A et al.. Body Mass Index and Waist Circumference as Predictors of Disability in Nonagenarians: The Vitality 90+ Study. J Gerontol A Biol Sci Med Sci. 2017;72 (11):1569-1574. doi: 10.1093/gerona/glx032. PubMed PMID:28329171 .
- Nevalainen, T, Kananen, L, Marttila, S, Jylhävä, J, Mononen, N, Kähönen, M et al.. Obesity accelerates epigenetic aging in middle-aged but not in elderly individuals. Clin Epigenetics. 2017;9 :20. doi: 10.1186/s13148-016-0301-7. PubMed PMID:28289477 PubMed Central PMC5310016.
2016
- Nevalainen, T, Kananen, L, Marttila, S, Jylhävä, J, Jylhä, M, Hervonen, A et al.. Increased Paternal Age at Conception Is Associated with Transcriptomic Changes Involved in Mitochondrial Function in Elderly Individuals. PLoS One. 2016;11 (11):e0167028. doi: 10.1371/journal.pone.0167028. PubMed PMID:27880854 PubMed Central PMC5120832.
- Lehtonen, JM, Forsström, S, Bottani, E, Viscomi, C, Baris, OR, Isoniemi, H et al.. FGF21 is a biomarker for mitochondrial translation and mtDNA maintenance disorders. Neurology. 2016;87 (22):2290-2299. doi: 10.1212/WNL.0000000000003374. PubMed PMID:27794108 PubMed Central PMC5270510.
- Alapirtti, T, Jylhävä, J, Raitanen, J, Mäkinen, R, Peltola, J, Hurme, MA et al.. The concentration of cell-free DNA in video-EEG patients is dependent on the epilepsy syndrome and duration of epilepsy. Neurol Res. 2016;38 (1):45-50. doi: 10.1080/01616412.2015.1127004. PubMed PMID:27118450.
- Jylhävä, J, Kananen, L, Raitanen, J, Marttila, S, Nevalainen, T, Hervonen, A et al.. Methylomic predictors demonstrate the role of NF-κB in old-age mortality and are unrelated to the aging-associated epigenetic drift. Oncotarget. 2016;7 (15):19228-41. doi: 10.18632/oncotarget.8278. PubMed PMID:27015559 PubMed Central PMC4991378.
- Enroth, L, Raitanen, J, Hervonen, A, Lehtimäki, T, Jylhävä, J, Hurme, M et al.. Cardiometabolic and Inflammatory Biomarkers as Mediators Between Educational Attainment and Functioning at the Age of 90 Years. J Gerontol A Biol Sci Med Sci. 2016;71 (3):412-9. doi: 10.1093/gerona/glv105. PubMed PMID:26328604 .