Publications

2025

  1. Ler, P, Mak, JKL, Reynolds, CA, Ploner, A, Pedersen, NL, Jylhävä, J et al.. A Longitudinal Study of the Bidirectional Temporal Dynamics Between Body Mass Index and Biological Aging. J Cachexia Sarcopenia Muscle. 2025;16 (3):e13824. doi: 10.1002/jcsm.13824. PubMed PMID:40342213 PubMed Central PMC12059470.
  2. Mak, JKL, Tan, KCB, Jylhävä, J, Hägg, S, Cheung, CL. Walking Speed and Risk of Cancer in Two Prospective Cohort Studies. J Cachexia Sarcopenia Muscle. 2025;16 (3):e13792. doi: 10.1002/jcsm.13792. PubMed PMID:40275681 PubMed Central PMC12022227.
  3. Tirkkonen, A, Mak, JKL, Eriksson, JG, Halonen, P, Jylhävä, J, Hägg, S et al.. Predicting cardiovascular morbidity and mortality with SCORE2 (OP) and Framingham risk estimates in combination with indicators of biological ageing. Age Ageing. 2025;54 (4):. doi: 10.1093/ageing/afaf075. PubMed PMID:40178198 PubMed Central PMC11966606.
  4. Viinanen, A, Ilmarinen, P, Mehtälä, J, Jylhävä, J, Ylisaukko-Oja, T, Idänpään-Heikkilä, JJ et al.. Factors associated with the development of severe asthma: A nationwide study (FINASTHMA). Ann Allergy Asthma Immunol. 2025;135 (1):47-55.e14. doi: 10.1016/j.anai.2025.03.002. PubMed PMID:40068799 .
  5. Yin, W, Li, X, Chen, R, Zhan, Y, Jylhävä, J, Fang, F et al.. Marital and living status and biological ageing trajectories: a longitudinal cohort study with a 20-year follow-up. Biogerontology. 2025;26 (1):34. doi: 10.1007/s10522-024-10171-1. PubMed PMID:39775304 PubMed Central PMC11711563.
  6. Ojalehto Lindfors, E, De Oliveira, TL, Reynolds, CA, Zhan, Y, Dahl Aslan, AK, Jylhävä, J et al.. Genetic influences, lifestyle and psychosocial aspects in relation to metabolically healthy obesity and conversion to a metabolically unhealthy state. Diabetes Obes Metab. 2025;27 (1):207-214. doi: 10.1111/dom.16004. PubMed PMID:39382007 PubMed Central PMC11618251.
  7. Short, E, ICCARP, Calimport, S, Bentley, B. Defining an ageing-related pathology, disease or syndrome: International Consensus Statement. Geroscience. 2025;47 (2):1713-1720. doi: 10.1007/s11357-024-01315-9. PubMed PMID:39304617 PubMed Central PMC11978578.
  8. Mohammadnejad, A, Ryg, J, Ewertz, M, Jylhävä, J, Hjelmborg, JV, Galvin, A et al.. Association of cancer with functional decline at old age: a longitudinal study in Danish twins. Scand J Public Health. 2025;53 (3):284-293. doi: 10.1177/14034948241240823. PubMed PMID:38570302 .
Search PubMed

2024

  1. Zylberberg, HM, Lebwohl, B MD, MS, Söderling, J, Kochar, B, Jylhävä, J, Green, PHR et al.. Older Adults With Celiac Disease Are At Increased Risk of Frailty: A Nationwide Cohort Study. Am J Gastroenterol. 2024; :. doi: 10.14309/ajg.0000000000003217. PubMed PMID:39569895 .
  2. Ojalehto Lindfors, E, De Oliveira, TL, Reynolds, CA, Zhan, Y, Dahl Aslan, AK, Jylhävä, J et al.. Genetic influences, lifestyle and psychosocial aspects in relation to metabolically healthy obesity and conversion to a metabolically unhealthy state. Diabetes Obes Metab. 2025;27 (1):207-214. doi: 10.1111/dom.16004. PubMed PMID:39382007 PubMed Central PMC11618251.
  3. Mohammadnejad, A, Jylhävä, J, Ewertz, M, Ryg, J, Hjelmborg, JVB, Galvin, A et al.. Is Cancer Associated With Frailty? Results From a Longitudinal Study of Old Danish Twins. J Gerontol A Biol Sci Med Sci. 2024;79 (11):. doi: 10.1093/gerona/glae225. PubMed PMID:39297899 .
  4. Short, E, ICCARP, Calimport, S, Bentley, B. Defining an ageing-related pathology, disease or syndrome: International Consensus Statement. Geroscience. 2024; :. doi: 10.1007/s11357-024-01315-9. PubMed PMID:39304617 .
  5. Short, E, Adcock, IM, Al-Sarireh, B, Ager, A, Ajjan, R, Akbar, N et al.. Defining an Ageing-Related Pathology, Disease or Syndrome: International Consensus Statement. medRxiv. 2024; :. doi: 10.1101/2024.09.02.24312951. PubMed PMID:39281746 PubMed Central PMC11398438.
  6. Haapanen, MJ, Kananen, L, Mikkola, TM, Jylhävä, J, Wasenius, NS, Eriksson, JG et al.. Frailty in Midlife as a Predictor of Changes in Body Composition from Midlife into Old Age: A Longitudinal Birth Cohort Study. Gerontology. 2024;70 (8):831-841. doi: 10.1159/000539204. PubMed PMID:38718772 PubMed Central PMC11309068.
  7. Mohammadnejad, A, Ryg, J, Ewertz, M, Jylhävä, J, Hjelmborg, JV, Galvin, A et al.. Association of cancer with functional decline at old age: a longitudinal study in Danish twins. Scand J Public Health. 2024; :14034948241240823. doi: 10.1177/14034948241240823. PubMed PMID:38570302 .
  8. Haapanen, MJ, Mikkola, TM, Jylhävä, J, Wasenius, NS, Kajantie, E, Eriksson, JG et al.. Lifestyle-related factors in late midlife as predictors of frailty from late midlife into old age: a longitudinal birth cohort study. Age Ageing. 2024;53 (4):. doi: 10.1093/ageing/afae066. PubMed PMID:38557664PubMed Central PMC10982848.
  9. Lopes De Oliveira, T, Tang, B, Bai, G, Sjölander, A, Jylhävä, J, Finkel, D et al.. Effects from medications on functional biomarkers of aging in three longitudinal studies of aging in Sweden. Aging Cell. 2024;23 (6):e14132. doi: 10.1111/acel.14132. PubMed PMID:38426357 PubMed Central PMC11296127.
  10. Mak, JKL, Skovgaard, AC, Nygaard, M, Kananen, L, Reynolds, CA, Wang, Y et al.. Epigenome-wide analysis of frailty: Results from two European twin cohorts. Aging Cell. 2024;23 (6):e14135. doi: 10.1111/acel.14135. PubMed PMID:38414347 PubMed Central PMC11166364.
  11. Ler, P, Ploner, A, Finkel, D, Reynolds, CA, Zhan, Y, Jylhävä, J et al.. Interplay of body mass index and metabolic syndrome: association with physiological age from midlife to late-life. Geroscience. 2024;46 (2):2605-2617. doi: 10.1007/s11357-023-01032-9. PubMed PMID:38102440PubMed Central PMC10828240.
  12. Mak, JKL, Karlsson, IK, Tang, B, Wang, Y, Pedersen, NL, Hägg, S et al.. Temporal Dynamics of Epigenetic Aging and Frailty From Midlife to Old Age. J Gerontol A Biol Sci Med Sci. 2024;79 (10):. doi: 10.1093/gerona/glad251. PubMed PMID:37889476 PubMed Central PMC11421301.

Search PubMed

2023

  1. Bednorz, A, Mak, JKL, Jylhävä, J, Religa, D. Use of Electronic Medical Records (EMR) in Gerontology: Benefits, Considerations and a Promising Future. Clin Interv Aging. 2023;18 :2171-2183. doi: 10.2147/CIA.S400887. PubMed PMID:38152074 PubMed Central PMC10752027.
  2. Ler, P, Ploner, A, Finkel, D, Reynolds, CA, Zhan, Y, Jylhävä, J et al.. Interplay of body mass index and metabolic syndrome: association with physiological age from midlife to late-life. Geroscience. 2024;46 (2):2605-2617. doi: 10.1007/s11357-023-01032-9. PubMed PMID:38102440PubMed Central PMC10828240.
  3. Kananen, L, Molnár, C, Ansker, F, Kozlowska, DJ, Hägg, S, Jylhävä, J et al.. Anticoagulant treatment and COVID-19 mortality among older adults living in nursing homes in Sweden. Health Sci Rep. 2023;6 (11):e1692. doi: 10.1002/hsr2.1692. PubMed PMID:38028709 PubMed Central PMC10644256.
  4. Mak, JKL, Karlsson, IK, Tang, B, Wang, Y, Pedersen, NL, Hägg, S et al.. Temporal dynamics of epigenetic aging and frailty from midlife to old age. J Gerontol A Biol Sci Med Sci. 2023; :. doi: 10.1093/gerona/glad251. PubMed PMID:37889476 .
  5. Dent, E, Hanlon, P, Sim, M, Jylhävä, J, Liu, Z, Vetrano, DL et al.. Recent developments in frailty identification, management, risk factors and prevention: A narrative review of leading journals in geriatrics and gerontology. Ageing Res Rev. 2023;91 :102082. doi: 10.1016/j.arr.2023.102082. PubMed PMID:37797723 .
  6. Bai, G, Wang, Y, Mak, JKL, Ericsson, M, Hägg, S, Jylhävä, J et al.. Is Frailty Different in Younger Adults Compared to Old? Prevalence, Characteristics, and Risk Factors of Early-Life and Late-Life Frailty in Samples from Sweden and UK. Gerontology. 2023;69 (12):1385-1393. doi: 10.1159/000534131. PubMed PMID:37769628 PubMed Central PMC10711760.
  7. Li, X, Ploner, A, Wang, Y, Mak, JKL, Lu, Y, Magnusson, PKE et al.. Rare functional variants in the CRP and G6PC genes modify the relationship between obesity and serum C-reactive protein in white British population. Mol Genet Genomic Med. 2023;11 (12):e2255. doi: 10.1002/mgg3.2255. PubMed PMID:37493001 PubMed Central PMC10724514.
  8. Mak, JKL, Religa, D, Jylhävä, J. Automated frailty scores: towards clinical implementation. Aging (Albany NY). 2023;15 (11):4571-4573. doi: 10.18632/aging.204815. PubMed PMID:37294544 PubMed Central PMC10292878.
  9. Mak, JKL, Kananen, L, Qin, C, Kuja-Halkola, R, Tang, B, Lin, J et al.. Unraveling the metabolic underpinnings of frailty using multicohort observational and Mendelian randomization analyses. Aging Cell. 2023;22 (8):e13868. doi: 10.1111/acel.13868. PubMed PMID:37184129 PubMed Central PMC10410014.
  10. Ojalehto, E, Zhan, Y, Jylhävä, J, Reynolds, CA, Dahl Aslan, AK, Karlsson, IK et al.. Genetically and environmentally predicted obesity in relation to cardiovascular disease: a nationwide cohort study. EClinicalMedicine. 2023;58 :101943. doi: 10.1016/j.eclinm.2023.101943. PubMed PMID:37181410 PubMed Central PMC10166783.
  11. Mak, JKL, McMurran, CE, Kuja-Halkola, R, Hall, P, Czene, K, Jylhävä, J et al.. Clinical biomarker-based biological aging and risk of cancer in the UK Biobank. Br J Cancer. 2023;129 (1):94-103. doi: 10.1038/s41416-023-02288-w. PubMed PMID:37120669 PubMed Central PMC10307789.
  12. Tang, B, Li, X, Wang, Y, Sjölander, A, Johnell, K, Thambisetty, M et al.. Longitudinal associations between use of antihypertensive, antidiabetic, and lipid-lowering medications and biological aging. Geroscience. 2023;45 (3):2065-2078. doi: 10.1007/s11357-023-00784-8. PubMed PMID:37032369 PubMed Central PMC10400489.
  13. Mak, JKL, Kuja-Halkola, R, Wang, Y, Hägg, S, Jylhävä, J. Can frailty scores predict the incidence of cancer? Results from two large population-based studies. Geroscience. 2023;45 (3):2051-2064. doi: 10.1007/s11357-023-00783-9. PubMed PMID:36997701 PubMed Central PMC10400738.
  14. Kananen, L, Hong, X, Annetorp, M, Mak, JKL, Jylhävä, J, Eriksdotter, M et al.. Health progression for Covid-19 survivors hospitalized in geriatric clinics in Sweden. PLoS One. 2023;18 (3):e0283344. doi: 10.1371/journal.pone.0283344. PubMed PMID:36947542 PubMed Central PMC10032538.
  15. Mak, JKL, Eriksdotter, M, Annetorp, M, Kuja-Halkola, R, Kananen, L, Boström, AM et al.. Two Years with COVID-19: The Electronic Frailty Index Identifies High-Risk Patients in the Stockholm GeroCovid Study. Gerontology. 2023;69 (4):396-405. doi: 10.1159/000527206. PubMed PMID:36450240 PubMed Central PMC9747746.
  16. Haapanen, MJ, Mikkola, TM, Kortelainen, L, Jylhävä, J, Wasenius, NS, Kajantie, E et al.. Body Composition in Late Midlife as a Predictor of Accelerated Age-associated Deficit-accumulation From Late Midlife into Old Age: A Longitudinal Birth Cohort Study. J Gerontol A Biol Sci Med Sci. 2023;78 (6):980-987. doi: 10.1093/gerona/glac233. PubMed PMID:36434783 PubMed Central PMC10235203.
  17. Mak, JKL, Kuja-Halkola, R, Bai, G, Hassing, LB, Pedersen, NL, Hägg, S et al.. Genetic and Environmental Influences on Longitudinal Frailty Trajectories From Adulthood into Old Age. J Gerontol A Biol Sci Med Sci. 2023;78 (2):333-341. doi: 10.1093/gerona/glac197. PubMed PMID:36124734 PubMed Central PMC9951061.
  18. Kananen, L, Hurme, M, Bürkle, A, Moreno-Villanueva, M, Bernhardt, J, Debacq-Chainiaux, F et al.. Circulating cell-free DNA in health and disease – the relationship to health behaviours, ageing phenotypes and metabolomics. Geroscience. 2023;45 (1):85-103. doi: 10.1007/s11357-022-00590-8. PubMed PMID:35864375 PubMed Central PMC9886738.
  19. Wennberg, AM, Yin, W, Fang, F, Pedersen, NL, Hägg, S, Jylhävä, J et al.. Comparison of two different frailty scales in the longitudinal Swedish Adoption/Twin Study of Aging (SATSA). Scand J Public Health. 2023;51 (4):587-594. doi: 10.1177/14034948211059958. PubMed PMID:34904462PubMed Central PMC10265292.