2025
- Ler, P, Mak, JKL, Reynolds, CA, Ploner, A, Pedersen, NL, Jylhävä, J et al.. A Longitudinal Study of the Bidirectional Temporal Dynamics Between Body Mass Index and Biological Aging. J Cachexia Sarcopenia Muscle. 2025;16 (3):e13824. doi: 10.1002/jcsm.13824. PubMed PMID:40342213 PubMed Central PMC12059470.
- Mak, JKL, Tan, KCB, Jylhävä, J, Hägg, S, Cheung, CL. Walking Speed and Risk of Cancer in Two Prospective Cohort Studies. J Cachexia Sarcopenia Muscle. 2025;16 (3):e13792. doi: 10.1002/jcsm.13792. PubMed PMID:40275681 PubMed Central PMC12022227.
- Tirkkonen, A, Mak, JKL, Eriksson, JG, Halonen, P, Jylhävä, J, Hägg, S et al.. Predicting cardiovascular morbidity and mortality with SCORE2 (OP) and Framingham risk estimates in combination with indicators of biological ageing. Age Ageing. 2025;54 (4):. doi: 10.1093/ageing/afaf075. PubMed PMID:40178198 PubMed Central PMC11966606.
- Viinanen, A, Ilmarinen, P, Mehtälä, J, Jylhävä, J, Ylisaukko-Oja, T, Idänpään-Heikkilä, JJ et al.. Factors associated with the development of severe asthma: A nationwide study (FINASTHMA). Ann Allergy Asthma Immunol. 2025;135 (1):47-55.e14. doi: 10.1016/j.anai.2025.03.002. PubMed PMID:40068799 .
- Yin, W, Li, X, Chen, R, Zhan, Y, Jylhävä, J, Fang, F et al.. Marital and living status and biological ageing trajectories: a longitudinal cohort study with a 20-year follow-up. Biogerontology. 2025;26 (1):34. doi: 10.1007/s10522-024-10171-1. PubMed PMID:39775304 PubMed Central PMC11711563.
- Ojalehto Lindfors, E, De Oliveira, TL, Reynolds, CA, Zhan, Y, Dahl Aslan, AK, Jylhävä, J et al.. Genetic influences, lifestyle and psychosocial aspects in relation to metabolically healthy obesity and conversion to a metabolically unhealthy state. Diabetes Obes Metab. 2025;27 (1):207-214. doi: 10.1111/dom.16004. PubMed PMID:39382007 PubMed Central PMC11618251.
- Short, E, ICCARP, Calimport, S, Bentley, B. Defining an ageing-related pathology, disease or syndrome: International Consensus Statement. Geroscience. 2025;47 (2):1713-1720. doi: 10.1007/s11357-024-01315-9. PubMed PMID:39304617 PubMed Central PMC11978578.
- Mohammadnejad, A, Ryg, J, Ewertz, M, Jylhävä, J, Hjelmborg, JV, Galvin, A et al.. Association of cancer with functional decline at old age: a longitudinal study in Danish twins. Scand J Public Health. 2025;53 (3):284-293. doi: 10.1177/14034948241240823. PubMed PMID:38570302 .
2024
- Zylberberg, HM, Lebwohl, B MD, MS, Söderling, J, Kochar, B, Jylhävä, J, Green, PHR et al.. Older Adults With Celiac Disease Are At Increased Risk of Frailty: A Nationwide Cohort Study. Am J Gastroenterol. 2024; :. doi: 10.14309/ajg.0000000000003217. PubMed PMID:39569895 .
- Ojalehto Lindfors, E, De Oliveira, TL, Reynolds, CA, Zhan, Y, Dahl Aslan, AK, Jylhävä, J et al.. Genetic influences, lifestyle and psychosocial aspects in relation to metabolically healthy obesity and conversion to a metabolically unhealthy state. Diabetes Obes Metab. 2025;27 (1):207-214. doi: 10.1111/dom.16004. PubMed PMID:39382007 PubMed Central PMC11618251.
- Mohammadnejad, A, Jylhävä, J, Ewertz, M, Ryg, J, Hjelmborg, JVB, Galvin, A et al.. Is Cancer Associated With Frailty? Results From a Longitudinal Study of Old Danish Twins. J Gerontol A Biol Sci Med Sci. 2024;79 (11):. doi: 10.1093/gerona/glae225. PubMed PMID:39297899 .
- Short, E, ICCARP, Calimport, S, Bentley, B. Defining an ageing-related pathology, disease or syndrome: International Consensus Statement. Geroscience. 2024; :. doi: 10.1007/s11357-024-01315-9. PubMed PMID:39304617 .
- Short, E, Adcock, IM, Al-Sarireh, B, Ager, A, Ajjan, R, Akbar, N et al.. Defining an Ageing-Related Pathology, Disease or Syndrome: International Consensus Statement. medRxiv. 2024; :. doi: 10.1101/2024.09.02.24312951. PubMed PMID:39281746 PubMed Central PMC11398438.
- Haapanen, MJ, Kananen, L, Mikkola, TM, Jylhävä, J, Wasenius, NS, Eriksson, JG et al.. Frailty in Midlife as a Predictor of Changes in Body Composition from Midlife into Old Age: A Longitudinal Birth Cohort Study. Gerontology. 2024;70 (8):831-841. doi: 10.1159/000539204. PubMed PMID:38718772 PubMed Central PMC11309068.
- Mohammadnejad, A, Ryg, J, Ewertz, M, Jylhävä, J, Hjelmborg, JV, Galvin, A et al.. Association of cancer with functional decline at old age: a longitudinal study in Danish twins. Scand J Public Health. 2024; :14034948241240823. doi: 10.1177/14034948241240823. PubMed PMID:38570302 .
- Haapanen, MJ, Mikkola, TM, Jylhävä, J, Wasenius, NS, Kajantie, E, Eriksson, JG et al.. Lifestyle-related factors in late midlife as predictors of frailty from late midlife into old age: a longitudinal birth cohort study. Age Ageing. 2024;53 (4):. doi: 10.1093/ageing/afae066. PubMed PMID:38557664PubMed Central PMC10982848.
- Lopes De Oliveira, T, Tang, B, Bai, G, Sjölander, A, Jylhävä, J, Finkel, D et al.. Effects from medications on functional biomarkers of aging in three longitudinal studies of aging in Sweden. Aging Cell. 2024;23 (6):e14132. doi: 10.1111/acel.14132. PubMed PMID:38426357 PubMed Central PMC11296127.
- Mak, JKL, Skovgaard, AC, Nygaard, M, Kananen, L, Reynolds, CA, Wang, Y et al.. Epigenome-wide analysis of frailty: Results from two European twin cohorts. Aging Cell. 2024;23 (6):e14135. doi: 10.1111/acel.14135. PubMed PMID:38414347 PubMed Central PMC11166364.
- Ler, P, Ploner, A, Finkel, D, Reynolds, CA, Zhan, Y, Jylhävä, J et al.. Interplay of body mass index and metabolic syndrome: association with physiological age from midlife to late-life. Geroscience. 2024;46 (2):2605-2617. doi: 10.1007/s11357-023-01032-9. PubMed PMID:38102440PubMed Central PMC10828240.
- Mak, JKL, Karlsson, IK, Tang, B, Wang, Y, Pedersen, NL, Hägg, S et al.. Temporal Dynamics of Epigenetic Aging and Frailty From Midlife to Old Age. J Gerontol A Biol Sci Med Sci. 2024;79 (10):. doi: 10.1093/gerona/glad251. PubMed PMID:37889476 PubMed Central PMC11421301.
2023
- Bednorz, A, Mak, JKL, Jylhävä, J, Religa, D. Use of Electronic Medical Records (EMR) in Gerontology: Benefits, Considerations and a Promising Future. Clin Interv Aging. 2023;18 :2171-2183. doi: 10.2147/CIA.S400887. PubMed PMID:38152074 PubMed Central PMC10752027.
- Ler, P, Ploner, A, Finkel, D, Reynolds, CA, Zhan, Y, Jylhävä, J et al.. Interplay of body mass index and metabolic syndrome: association with physiological age from midlife to late-life. Geroscience. 2024;46 (2):2605-2617. doi: 10.1007/s11357-023-01032-9. PubMed PMID:38102440PubMed Central PMC10828240.
- Kananen, L, Molnár, C, Ansker, F, Kozlowska, DJ, Hägg, S, Jylhävä, J et al.. Anticoagulant treatment and COVID-19 mortality among older adults living in nursing homes in Sweden. Health Sci Rep. 2023;6 (11):e1692. doi: 10.1002/hsr2.1692. PubMed PMID:38028709 PubMed Central PMC10644256.
- Mak, JKL, Karlsson, IK, Tang, B, Wang, Y, Pedersen, NL, Hägg, S et al.. Temporal dynamics of epigenetic aging and frailty from midlife to old age. J Gerontol A Biol Sci Med Sci. 2023; :. doi: 10.1093/gerona/glad251. PubMed PMID:37889476 .
- Dent, E, Hanlon, P, Sim, M, Jylhävä, J, Liu, Z, Vetrano, DL et al.. Recent developments in frailty identification, management, risk factors and prevention: A narrative review of leading journals in geriatrics and gerontology. Ageing Res Rev. 2023;91 :102082. doi: 10.1016/j.arr.2023.102082. PubMed PMID:37797723 .
- Bai, G, Wang, Y, Mak, JKL, Ericsson, M, Hägg, S, Jylhävä, J et al.. Is Frailty Different in Younger Adults Compared to Old? Prevalence, Characteristics, and Risk Factors of Early-Life and Late-Life Frailty in Samples from Sweden and UK. Gerontology. 2023;69 (12):1385-1393. doi: 10.1159/000534131. PubMed PMID:37769628 PubMed Central PMC10711760.
- Li, X, Ploner, A, Wang, Y, Mak, JKL, Lu, Y, Magnusson, PKE et al.. Rare functional variants in the CRP and G6PC genes modify the relationship between obesity and serum C-reactive protein in white British population. Mol Genet Genomic Med. 2023;11 (12):e2255. doi: 10.1002/mgg3.2255. PubMed PMID:37493001 PubMed Central PMC10724514.
- Mak, JKL, Religa, D, Jylhävä, J. Automated frailty scores: towards clinical implementation. Aging (Albany NY). 2023;15 (11):4571-4573. doi: 10.18632/aging.204815. PubMed PMID:37294544 PubMed Central PMC10292878.
- Mak, JKL, Kananen, L, Qin, C, Kuja-Halkola, R, Tang, B, Lin, J et al.. Unraveling the metabolic underpinnings of frailty using multicohort observational and Mendelian randomization analyses. Aging Cell. 2023;22 (8):e13868. doi: 10.1111/acel.13868. PubMed PMID:37184129 PubMed Central PMC10410014.
- Ojalehto, E, Zhan, Y, Jylhävä, J, Reynolds, CA, Dahl Aslan, AK, Karlsson, IK et al.. Genetically and environmentally predicted obesity in relation to cardiovascular disease: a nationwide cohort study. EClinicalMedicine. 2023;58 :101943. doi: 10.1016/j.eclinm.2023.101943. PubMed PMID:37181410 PubMed Central PMC10166783.
- Mak, JKL, McMurran, CE, Kuja-Halkola, R, Hall, P, Czene, K, Jylhävä, J et al.. Clinical biomarker-based biological aging and risk of cancer in the UK Biobank. Br J Cancer. 2023;129 (1):94-103. doi: 10.1038/s41416-023-02288-w. PubMed PMID:37120669 PubMed Central PMC10307789.
- Tang, B, Li, X, Wang, Y, Sjölander, A, Johnell, K, Thambisetty, M et al.. Longitudinal associations between use of antihypertensive, antidiabetic, and lipid-lowering medications and biological aging. Geroscience. 2023;45 (3):2065-2078. doi: 10.1007/s11357-023-00784-8. PubMed PMID:37032369 PubMed Central PMC10400489.
- Mak, JKL, Kuja-Halkola, R, Wang, Y, Hägg, S, Jylhävä, J. Can frailty scores predict the incidence of cancer? Results from two large population-based studies. Geroscience. 2023;45 (3):2051-2064. doi: 10.1007/s11357-023-00783-9. PubMed PMID:36997701 PubMed Central PMC10400738.
- Kananen, L, Hong, X, Annetorp, M, Mak, JKL, Jylhävä, J, Eriksdotter, M et al.. Health progression for Covid-19 survivors hospitalized in geriatric clinics in Sweden. PLoS One. 2023;18 (3):e0283344. doi: 10.1371/journal.pone.0283344. PubMed PMID:36947542 PubMed Central PMC10032538.
- Mak, JKL, Eriksdotter, M, Annetorp, M, Kuja-Halkola, R, Kananen, L, Boström, AM et al.. Two Years with COVID-19: The Electronic Frailty Index Identifies High-Risk Patients in the Stockholm GeroCovid Study. Gerontology. 2023;69 (4):396-405. doi: 10.1159/000527206. PubMed PMID:36450240 PubMed Central PMC9747746.
- Haapanen, MJ, Mikkola, TM, Kortelainen, L, Jylhävä, J, Wasenius, NS, Kajantie, E et al.. Body Composition in Late Midlife as a Predictor of Accelerated Age-associated Deficit-accumulation From Late Midlife into Old Age: A Longitudinal Birth Cohort Study. J Gerontol A Biol Sci Med Sci. 2023;78 (6):980-987. doi: 10.1093/gerona/glac233. PubMed PMID:36434783 PubMed Central PMC10235203.
- Mak, JKL, Kuja-Halkola, R, Bai, G, Hassing, LB, Pedersen, NL, Hägg, S et al.. Genetic and Environmental Influences on Longitudinal Frailty Trajectories From Adulthood into Old Age. J Gerontol A Biol Sci Med Sci. 2023;78 (2):333-341. doi: 10.1093/gerona/glac197. PubMed PMID:36124734 PubMed Central PMC9951061.
- Kananen, L, Hurme, M, Bürkle, A, Moreno-Villanueva, M, Bernhardt, J, Debacq-Chainiaux, F et al.. Circulating cell-free DNA in health and disease – the relationship to health behaviours, ageing phenotypes and metabolomics. Geroscience. 2023;45 (1):85-103. doi: 10.1007/s11357-022-00590-8. PubMed PMID:35864375 PubMed Central PMC9886738.
- Wennberg, AM, Yin, W, Fang, F, Pedersen, NL, Hägg, S, Jylhävä, J et al.. Comparison of two different frailty scales in the longitudinal Swedish Adoption/Twin Study of Aging (SATSA). Scand J Public Health. 2023;51 (4):587-594. doi: 10.1177/14034948211059958. PubMed PMID:34904462PubMed Central PMC10265292.