Virtanen A, Huttala O, Tihtonen K, Toimela T, Heinonen T, Laivuori H, Uotila J. Therapeutic doses of metformin do not have impact on angiogenesis in presence of sera from pre-eclamptic, IUGR and healthy pregnancies [published online ahead of print, 2020 Jul 6]. Pregnancy Hypertens. 2020;22:7-13. doi:10.1016/j.preghy.2020.06.008

Huttala O, Sarkanen JR, Mannerström M, Toimela T, Heinonen T, Ylikomi T. Development of novel human in vitro vascularized adipose tissue model with functional macrophages [published online ahead of print, 2020 Jun 10]. Cytotechnology. 2020;10.1007/s10616-020-00407-6. doi:10.1007/s10616-020-00407-6

Rahkonen S, Koskinen E, Pölönen I, et al. Multilabel segmentation of cancer cell culture on vascular structures with deep neural networks [published correction appears in J Med Imaging (Bellingham). 2020 Mar;7(2):029801]. J Med Imaging (Bellingham). 2020;7(2):024001. doi:10.1117/1.JMI.7.2.024001

Rahkonen S, Koskinen E, Pölönen I, et al. Erratum: Multilabel segmentation of cancer cell culture on vascular structures with deep neural networks (Erratum). J Med Imaging (Bellingham). 2020;7(2):029801. doi:10.1117/1.JMI.7.2.029801

Huttala O, Staff S, Heinonen T, Mäenpää J, Tanner M, Ylikomi T. In Vitro Vascular Network Modified to Function as Culture Platform and Angiogenic Induction Potential Test for Cancer Cells. Int J Mol Sci. 2020;21(5):1833. Published 2020 Mar 6. doi:10.3390/ijms21051833

Huttala O, Sarkanen JR, Heinonen T, Ylikomi T. Presence of vasculature results in faster insulin response in adipocytes in vascularized adipose tissue model. ALTEX. 2019;36(3):419-434. doi: 10.14573/altex.1811271. Epub 2019 Mar 15.

Virtanen J, Toivanen M, Toimela T, Heinonen T, Tuukkanen S. Direct Measurement of Contraction Force in Human Cardiac Tissue Model Using Piezoelectric Cantilever Sensor Technique. Current Applied Physics. 2019 Oct 25;20(1):155-160.

Virtanen A, Huttala O, Tihtonen K, Toimela T, Heinonen T, Uotila J. Angiogenic capacity in pre-eclampsia and uncomplicated pregnancy estimated by
assay of angiogenic proteins and an in vitro vasculogenesis/angiogenesis test. Angiogenesis. 2019, 22 (1),67-74.

Bal-Price A, Hogberg HT, Crofton KM,  Danieshan M, FrizGerald RE, Crofton KM, Fritsche E, Heinonen T, Hougaard Bennekou S, Klima S, Piersma AH, Sachana M, Shaefer TJ, Terron A, Monnet-Tschudi F, Viviani B, Waldmann T, Westerink RHS, Wilks MF., Witters H, Zurich M-G and Leist M. t4 Workshop Report. Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity. ALTEX preprint published February 23, 2018, version 2.

Stuard SB and Heinonen T. Relevance and Application of Read‐Across – Mini Review of European Consensus Platform for Alternatives and Scandinavian Society for Cell Toxicology 2017 Workshop Session. Basic Clin Pharmacol Toxicol. 2018.

Huttala O, Palmroth M, Hemminki P, Toimela T, Heinonen T, Ylikomi T, Sarkanen JR. Development of Versatile Human In Vitro Vascularized Adipose Tissue Model with Serum-Free Angiogenesis and Natural Adipogenesis Induction. Basic Clin Pharmacol Toxicol. 2018 Feb 14. doi: 10.1111/bcpt.12987. [Epub ahead of print]

Mannerström M, Toimela T, Sarkanen JR, Heinonen T 2017: Human BJ Fibroblasts is an Alternative to Mouse BALB/c 3T3 Cells in In Vitro Neutral Red Uptake Assay. Basic Clin Pharmacol Toxicol. 2017 Apr 4. doi: 10.1111/bcpt.12790.

Vuorenpää H, Penttinen K, Heinonen T, Pekkanen-Mattila M, Sarkanen J-R, Ylikomi T and Aalto-Setälä K. Maturation of Human Pluripotent Stem Cell Derived Cardiomyocytes Is Improved in Cardiovascular Construct. Cytotechnology, 2017. 69(5), 785-800.

Senn P(1), Roccio M, Hahnewald S, Frick C, Kwiatkowska M, Ishikawa M, Bako P, Li H, Edin F, Liu W, Rask-Andersen H, Pyykkö I, Zou J, Mannerström M, Keppner H, Homsy A, Laux E, Llera M, Lellouche JP, Ostrovsky S, Banin E, Gedanken A, Perkas N, Wank U, Wiesmüller KH, Mistrík P, Benav H, Garnham C, Jolly C, Gander F, Ulrich P, Müller M, Löwenheim H. NANOCI-Nanotechnology Based Cochlear Implant With Gapless Interface to Auditory Neurons. Otol Neurotol. 2017 Sep;38(8):e224-e231.

Toimela T, Huttala O, Sabell E, Mannerström M, Sarkanen JR, Ylikomi T, Heinonen T: Intra-laboratory validated human cell-based in vitro vasculogenesis/angiogenesis test with serum-free medium. Reprod Toxicol 2017 Jun;70:116-125. doi: 10.1016/j.reprotox.2016.11.015. Epub 2016 Nov 30.

Virtanen A, Toimela T, Tihtonen K, Sarkanen JR, Huttala O, Heinonen T and Uotila J:Strong inhibitory effect of preeclampsia serum on angiogenesis detected in vitro by human cell based angiogenesis  tests. Pregnancy Hypertens 2016 Oct;6(4):367-373. doi: 10.1016/j.preghy.2016.08.239. Epub 2016 Aug 28.

Huttala O, Mysore R, Sarkanen JR, Heinonen T, Olkkon en VM, Ylikomi T. Differentiation of human adipose stromal cells in vitro into insulin-sensitive adipocytes. Cell Tissue Res 366(1):63-74, 2016.

Langley GR, Adcock I, Busquet F, Crofton KM, Csernok E, Giese C, Heinonen T, Herrmann K, Hofmann-Apitius M, Landesmann B, Marshall L, McIvor E, Muotri A, Noor F, Schutte K, Seidle T, van de Stolpe A, Van Esch H, Willett C, Woszczek G. Towards a 21st-century roadmap for biomedical research and drug discovery: Consensus report and recommendations. Drug Discovery Today, November 2016. DOI

Mannerström M, Zou J, Toimela T, Pyykkö I, Heinonen T. The applicability of conventional cytotoxicity assays to predict safety/toxicity of mesoporous silica nanoparticles, silver and gold nanoparticles and multi-walled carbon nanotubes. Toxicology in Vitro 37:113-120, 2016. DOI:10.1016/j.tiv.2016.09.012.

Bondarenko OM, Heinlaan M, Sihtmäe M, Ivask A, Kurvet I, Joonas E, Jemec A, Mannerström M, Heinonen T, Rekulapelly R, Singh S, Zou J, Pyykkö I, Drobne D,    Kahru A. Multilaboratory evaluation of 15 bioassays for (eco)toxicity screening and hazard ranking of engineered nanomaterials: FP7 project NANOVALID. Nanotoxicology 10(9):1-45, 2016.

Laitinen A, Lampinen M, Liedtke S, Kilpinen L, Kerkelä E, Sarkanen J-R, Heinonen T, Kögler G, Laitinen S. The effects of culture conditions on the functionality of efficiently obtained mesenchymal stromal cells from human cord blood. Cytotherapy 18, 423-437, 2016 DOI: 10.1016/j.jcyt.2015.11.014.

Huttala O, Vuorenpää H, Toimela T, Uotila J, Kuokkanen H, Ylikomi T, Sarkanen JR, Heinonen T. Human vascular model with defined stimulation medium – A characterisation study. Altex 32(2):125-36, 2015.

Bal-Price A, Crofton KM, Leist M, Allen S, Arand M, Buetler T, Delrue N, FitzGerald RE, Hartung T, Heinonen T, Hogberg H, Bennekou SH, Lichtensteiger W, Oggier D, Paparella M, Axelstad M, Piersma A, Rached E, Schilter B, Schmuck G, Stoppini L, Tongiorgi E, Tiramani M, Monnet-Tschudi F, Wilks M F, Ylikomi T, Fritsche E. International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes. Arch Toxicol.89(2):269-87, 2015. doi: 10.1007/s00204-015-1464-2. Epub 2015 Jan 25.

Heinonen T, Gaus W. Cross matching observations on toxicological and clinical data for the assessment of tolerability and safety of Ginkgo biloba leaf extract. Toxicology. 327, 95–115, 2015. doi:10.1016/j.tox.2014.10.013

Heinonen T. Better science with human cell-based organ and tissue models (Björn Ekwall Memorial Award Lecture). Atla, 43, 1-10, 2015.

Vuorenpaa H, Ikonen L, Kujala K, Huttala O, Sarkanen JR, Ylikomi T, Aalto-Setälä K, Heinonen T. Novel in vitro cardiovascular contructs composed of a vascular-like network and cardiomyocytes. In vitro Cellular & Molecular developmental biology- Animal 50(4):275-86, 2014.

Zou J, Feng H, Mannerström M, Heinonen T, Pyykkö I: Toxicity of silver nanoparticle in rat ear and BALB/c 3T3 cell line. Journal of Nanobiotechnology 12:52, 2014.

Knudsen LE., Mathiesen L,  Nielsen JB, Tähti H and Heinonen T. Workshop of Scandinavian Society for Cell Toxicology 25-27 September 2013 in Denmark. Basic & Clinical Pharmacology & Toxicology, 2014, 115, 1-3.

Heinonen T, Louekari K, Tähti H. Need for harmonized strategies and improved assessment of carcinogenic and genotoxic potencies of chemical substances. Journal of Translational Toxicology. 1, 76-87, 2014.

Heinonen T, Tähti H. Eläinkokeettomat menetelmät tutkimuksessa ja testauksessa. SIC! lääketietoa FIMEAsta 1/2014, sivut 42-45.

Heinonen T, Tähti H: Eläinkokeeton toksikologia kemikaalien turvallisuustestauksessa. Duodecim 129: 1686-94, 2013.

Heinonen T, Louekari K, Tähti H: Need for harmonized strategies and improved assessment of carcinogenic and genotoxic potencies of chemical substances. Journal of Translational Toxicology 1, 1-12, 2013.

Heinonen T, Tähti H, Vähäkangas K and Blaauboer BJ. Towards toxicity assessment without animals. 28th workshop of SSCT and FINCOPA seminar 21-23 September 2011, Tampere, Finland (Editorial). Toxicology in Vitro. 27(5), 1563-1564, 2013.

Sarkanen JR, Vuorenpää H, Huttala O, Mannerström B, Kuokkanen H, Miettinen S, Heinonen T, Ylikomi T.: Adipose stromal cell tubule network model provides a versatile tool for vascular research and tissue engineering. Cells Tissues Organs. 196(5):385-97, 2012.

Sarkanen JR, Ruusuvuori P, Kuokkanen H, Paavonen T, Ylikomi T.: Bioactive acellular implant induces angiogenesis and adipogenesis and sustained soft tissue restoration in vivo. Tissue Eng Part A. 18(23-24):2568-80, 2012.

Sarkanen JR, Kaila V, Mannerström B, Räty S, Kuokkanen H, Miettinen S, Ylikomi T.: Human adipose tissue extract induces angiogenesis and adipogenesis in vitro. Tissue Eng Part A. 18(1-2):17-25, 2012.

Adler S, Basketter D, Creton S, Pelkonen O, van Benthem J, Zuang V, Andersen KE, Angers-Loustau A, Aptula A, Bal-Price A, Benfenati E, Bernauer U, Bessems J, Bois FY, Boobis A, Brandon E, Bremer S, Broschard T, Casati S, Coecke S, Corvi R, Cronin M, Daston G, Dekant W, Felter S, Grignard E, Gundert-Remy U, Heinonen T, Kimber I, Kleinjans J, Komulainen H, Kreiling R, Kreysa J, Leite SB, Loizou G, Maxwell G, Mazzatorta, P., Munn S, Pfuhler S, Phrakonkham P, Piersma A, Poth A, Prieto P, Repetto G, Rogiers V, Schoeters G, Schwarz M, Serafimova R, Tahti H, Testai E, van Delft J, van Loveren H, Vinken M, Worth A, Zaldivar JM, 2011. Alternative (non-animal) methods for cosmetics testing: current status and future prospects. Arch Toxicol. 85, 367-485, 2010

Tähti H, Heinonen T. Vaihtoehtoiset menetelmät kemikaalien turvallisuustestauksessa. Solubiologi No 2, 10-16, 2010.

Diallo H. Veri-aivoesteen mallintaminen in vitro. Solubiologi No 2, 17-21,2010.

Heinonen T, Mannerström M. Eläinkokeille vaihtoehtoisten testimenetelmien kehittäminen, optimointi ja validointi. Solubiologi No 2, 23-25, 2010.

Sarkanen JR, Heinonen T. In vitro-verisuonimallin validointi. Solubiologi No 2, 26-33, 2010.

Sarkanen JR, Mannerström M,Vuorenpää H, Uotila J,Ylikomi T, Heinonen T: Intra-Laboratory Pre-Validation of a Human Cell Based in vitro Angiogenesis Assay for Testing Angiogenesis Modulators. Front Pharmacol. 1: 147, 2010.

Tarkkanen AM, Heinonen T, Jõgi R, Mentula S, van der Rest ME, Donskey CJ, Kemppainen T, Gurbanov K & Nord CE : P1A recombinant beta-lactamase prevents emergence of antimicrobial resistance in gut microflora of healthy subjects during intravenous administration of ampicillin. Antimicrob Agents Chemother. 53(6):2455-2462, 2009.

Hallier-Vanuxeem D, Prieto P, Culot M, Diallo H, Landry C, Tähti H, Cecchelli R: New strategy for alerting central nervous system toxicity: Integration of blood-brain barrier toxicity and permeability in neurotoxicity assessment. Toxicol In Vitro. 23(3):447-453, 2009.

Nevala H, Ylikomi T & Tähti H: Evaluation of the barrier properties of ARPE-19 cell line for in vitro blood-brain barrier model. Hum Exp Toxicol 27(10):741-749, 2008.

 Bläuer M, Tammela TL, Ylikomi T. A novel tissue-slice culture model for non-malignant human prostate. Cell Tissue Res. 332(3):489-498, 2008.
Toimela T, Tähti H & Ylikomi T: Comparison of automated pattern analysis machine vision time lapse system with traditional endpoint measurements in analyzing cell growth and cytotoxicity. ATLA 36:313-325, 2008.

Bläuer M, Heinonen PK, Rovio P & Ylikomi T: Effects of tamoxifen and raloxifene on normal human endometrial cells in an organotypic in vitro model. Eur J Pharmacol 592(1-3):13-18, 2008.

Pärssinen J, Kuukasjärvi T, Karhu R & Kallioniemi A: High-level amplification at 17q23 leads to coordinated overexpression of multiple adjacent genes in breast cancer. Br J Cancer. 96(8):1258-1264, 2007

Sarkanen JR, Nykky J, Siikanen J, Selinummi J, Ylikomi T, & Jalonen, TO: Cholesterol supports the retinoic acid-induced synaptic vesicle formation in differentiating human SH-SY5Y neuroblastoma cells. J Neurochem 102(6):1941-1952, 2007.

 Alarmo EL, Rauta J, Kauraniemi P, Karhu R, Kuukasjärvi T & Kallioniemi A: Bone morphogenetic protein 7 is widely overexpressed in primary breast cancer. Genes Chromosomes Cancer. 45(4):411-419, 2006.

Mannerström M, Toimela T, Ylikomi T & Tähti H: The combined use of human neural and liver cell lines and mouse hepatocytes improves the predictability of the neurotoxicity of selected drugs. Toxicol Lett 165(2):195-202, 2006.

 Rauta J, Alarmo EL, Kauraniemi P, Karhu R, Kuukasjärvi T & Kallioniemi A: The serine-threonine protein phosphatase PPM1D is frequently activated through amplification in aggressive primary breast tumours. Breast Cancer Res Treat. 95(3):257-263, 2006.

Selinummi J, Sarkanen JR, Niemistö A, Linne ML, Ylikomi T, Yli-Harja O & Jalonen TO: Quantification of vesicles in differentiating human SH-SY5Y neuroblastoma cells by automated image analysis. Neurosci Lett 396(2):102-107, 2006.

 Bläuer M, Heinonen PK, Martikainen PM, Tomas E & Ylikomi T: A novel organotypic culture model for normal human endometrium: regulation of epithelial cell proliferation by estradiol and medroxyprogesterone acetate. Hum Reprod 20:864-871, 2005.

Mannerstöm M & Tähti H: Glucose-uptake as a target of neurological drugs in glial and neuronal cell lines. Toxicol Lett, 151, 87-97, 2004.

 Toimela T & Tähti H: Mitochondrial viability and apoptosis induced by aluminum, mercury and methylmercury in cell lines of neural origin. Arch Toxicol, 78, 565-574, 2004.

Kakko I, Toimela T & Tähti H: The toxicity of pyrethroid compounds in neural cell cultures studied with total ATP, mitochondrial enzyme activity and microscopic photographing. Environ Toxicol Pharmacol 15, 95-102, 2004.

Kakko I, Toimela T &Tähti H: Oestradiol potentiates the effect of certain pyrethroid compounds in the MCF-7 human breast carcinoma cell line. Altern Lab. Anim. ATLA, 32, 383-390, 2004.

 Mannerström M & Tähti H: Modulation of glucose uptake in glial and neuronal cell lines by selected neurological drugs. Toxicol Lett. 151(1):87-97, 2004.

Toimela T, Mäenpää H, Mannerström M & Tähti H: Development of an in vitro blood-brain barrier model-cytotoxicity of mercury and aluminum. Toxicol Appl Pharmacol. 195(1):73-82, 2004.

Mäenpää H, Toimela T, Mannerström M, Saransaari P & Tähti H: Toxicity of selected cationic drugs in retinoblastomal cultures and in cocultures of retinoblastomal and retinal pigment epithelial cell lines. Neurochem Res. 29(1):305-11, 2004.

Szabó A, Varga V, Toimela T, Hiitelä K, Tähti H, Oja SS, Süveges I & Salminen L: Laser treatment of cultured retinal pigment epithelial cells-evaluation of the cellular damage in vitro. J Ocul Pharmacol Ther. 20(3):246-255, 2004