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Internal Medicine Haemodynamics

The DYNAMIC study focuses on non-invasive measurement of haemodynamics.

Publications 2006-2020

2020

  1. Kokko, E, Nevalainen, PI, Choudhary, MK, Koskela, J, Tikkakoski, A, Huhtala, H et al.. Aldosterone-to-renin ratio is related to arterial stiffness when the screening criteria of primary aldosteronism are not met. Sci Rep. 2020;10 (1):19804. doi: 10.1038/s41598-020-76718-7. PubMed PMID:33188272 PubMed Central PMC7666146.
  2. Honkonen, M, Vääräniemi, K, Saijonmaa, O, Nyman, A, Tikkakoski, AJ, Koskela, J et al.. Leukocyte telomere length is inversely associated with arterial wave reflection in 566 normotensive and never-treated hypertensive subjects. Aging (Albany NY). 2020;12 (12):12376-12392. doi: 10.18632/aging.103459. PubMed PMID:32575070 PubMed Central PMC7343461.
  3. Oinonen, L, Koskela, J, Eräranta, A, Tikkakoski, A, Kähönen, M, Niemelä, O et al.. Plasma total calcium concentration is associated with blood pressure and systemic vascular resistance in normotensive and never-treated hypertensive subjects. Blood Press. 2020;29 (3):137-148. doi: 10.1080/08037051.2019.1696180. PubMed PMID:31790289 .
  4. Suojanen, L, Haring, A, Tikkakoski, A, Huhtala, H, Kähönen, M, Eräranta, A et al.. Adverse influence of bisoprolol on central blood pressure in the upright position: a double-blind placebo-controlled cross-over study. J Hum Hypertens. 2020;34 (4):301-310. doi: 10.1038/s41371-019-0188-9. PubMed PMID:30886326 PubMed Central PMC7165126.

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2019

  1. Kangas, P, Tikkakoski, A, Kettunen, J, Eräranta, A, Huhtala, H, Kähönen, M et al.. Changes in hemodynamics associated with metabolic syndrome are more pronounced in women than in men. Sci Rep. 2019;9 (1):18377. doi: 10.1038/s41598-019-54926-0. PubMed PMID:31804574 PubMed Central PMC6895092.
  2. Oinonen, L, Koskela, J, Eräranta, A, Tikkakoski, A, Kähönen, M, Niemelä, O et al.. Plasma total calcium concentration is associated with blood pressure and systemic vascular resistance in normotensive and never-treated hypertensive subjects. Blood Press. 2020;29 (3):137-148. doi: 10.1080/08037051.2019.1696180. PubMed PMID:31790289 .
  3. Hautaniemi, EJ, Tikkakoski, AJ, Eräranta, A, Kähönen, M, Hämäläinen, E, Turpeinen, U et al.. Liquorice ingestion attenuates vasodilatation via exogenous nitric oxide donor but not via β2-adrenoceptor stimulation. PLoS One. 2019;14 (10):e0223654. doi: 10.1371/journal.pone.0223654. PubMed PMID:31626649 PubMed Central PMC6799927.
  4. Rimpelä, JM, Niiranen, T, Jula, A, Pörsti, IH, Tikkakoski, A, Havulinna, A et al.. Genome-wide association study of white-coat effect in hypertensive patients. Blood Press. 2019;28 (4):239-249. doi: 10.1080/08037051.2019.1604066. PubMed PMID:31044621 .
  5. Suojanen, L, Haring, A, Tikkakoski, A, Huhtala, H, Kähönen, M, Eräranta, A et al.. Adverse influence of bisoprolol on central blood pressure in the upright position: a double-blind placebo-controlled cross-over study. J Hum Hypertens. 2020;34 (4):301-310. doi: 10.1038/s41371-019-0188-9. PubMed PMID:30886326 PubMed Central PMC7165126.
  6. Choudhary, MK, Eräranta, A, Koskela, J, Tikkakoski, AJ, Nevalainen, PI, Kähönen, M et al.. Atherogenic index of plasma is related to arterial stiffness but not to blood pressure in normotensive and never-treated hypertensive subjects. Blood Press. 2019;28 (3):157-167. doi: 10.1080/08037051.2019.1583060. PubMed PMID:30821503 .
  7. Choudhary, MK, Eräranta, A, Tikkakoski, AJ, Koskela, J, Hautaniemi, EJ, Kähönen, M et al.. LDL cholesterol is associated with systemic vascular resistance and wave reflection in subjects naive to cardiovascular drugs. Blood Press. 2019;28 (1):4-14. doi: 10.1080/08037051.2018.1521263. PubMed PMID:30369274 .
  8. Kangas, P, Tikkakoski, A, Uitto, M, Viik, J, Bouquin, H, Niemelä, O et al.. Metabolic syndrome is associated with decreased heart rate variability in a sex-dependent manner: a comparison between 252 men and 249 women. Clin Physiol Funct Imaging. 2019;39 (2):160-167. doi: 10.1111/cpf.12551. PubMed PMID:30307694 .

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2018

  1. Choudhary, MK, Eräranta, A, Tikkakoski, AJ, Koskela, J, Hautaniemi, EJ, Kähönen, M et al.. LDL cholesterol is associated with systemic vascular resistance and wave reflection in subjects naive to cardiovascular drugs. Blood Press. 2019;28 (1):4-14. doi: 10.1080/08037051.2018.1521263. PubMed PMID:30369274 .
  2. Kangas, P, Tikkakoski, A, Uitto, M, Viik, J, Bouquin, H, Niemelä, O et al.. Metabolic syndrome is associated with decreased heart rate variability in a sex-dependent manner: a comparison between 252 men and 249 women. Clin Physiol Funct Imaging. 2019;39 (2):160-167. doi: 10.1111/cpf.12551. PubMed PMID:30307694 .
  3. Choudhary, MK, Eräranta, A, Tikkakoski, AJ, Bouquin, H, Hautaniemi, EJ, Kähönen, M et al.. Effect of present versus previous smoking on non-invasive haemodynamics. Sci Rep. 2018;8 (1):13643. doi: 10.1038/s41598-018-31904-6. PubMed PMID:30206258 PubMed Central PMC6134124.
  4. Rimpelä, JM, Pörsti, IH, Jula, A, Lehtimäki, T, Niiranen, TJ, Oikarinen, L et al.. Genome-wide association study of nocturnal blood pressure dipping in hypertensive patients. BMC Med Genet. 2018;19 (1):110. doi: 10.1186/s12881-018-0624-7. PubMed PMID:29973135 PubMed Central PMC6032801.
  5. Tikkakoski, AJ, Kangas, P, Suojanen, L, Tahvanainen, AM, Eräranta, A, Kähönen, MAP et al.. Salbutamol-induced Decrease in Augmentation Index is Related to the Parallel Increase in Heart Rate. Basic Clin Pharmacol Toxicol. 2018;123 (2):161-173. doi: 10.1111/bcpt.12988. PubMed PMID:29476697 .

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2017

  1. Hautaniemi, EJ, Tahvanainen, AM, Koskela, JK, Tikkakoski, AJ, Kähönen, M, Uitto, M et al.. Voluntary liquorice ingestion increases blood pressure via increased volume load, elevated peripheral arterial resistance, and decreased aortic compliance. Sci Rep. 2017;7 (1):10947. doi: 10.1038/s41598-017-11468-7. PubMed PMID:28887501 PubMed Central PMC5591274.
  2. Suojanen, L, Haring, A, Tikkakoski, A, Koskela, JK, Tahvanainen, AM, Huhtala, H et al.. Haemodynamic Influences of Bisoprolol in Hypertensive Middle-Aged Men: A Double-Blind, Randomized, Placebo-Controlled Cross-Over Study. Basic Clin Pharmacol Toxicol. 2017;121 (2):130-137. doi: 10.1111/bcpt.12771. PubMed PMID:28256104 .
  3. Eräranta, A, Tikkakoski, A, Pörsti, IH. Byung Gyu Kim et al.: Reduced systemic vascular resistance is the underlying hemodynamic mechanism in nitrate-stimulated vasovagal syncope during head-up tilt-table test. J Arrhythm. 2017;33 (1):6. doi: 10.1016/j.joa.2016.04.001. PubMed PMID:28217221 PubMed Central PMC5300835.

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2016

  1. Eräranta, A, Tikkakoski, A, Pörsti, IH. Byung Gyu Kim et al.: Reduced systemic vascular resistance is the underlying hemodynamic mechanism in nitrate-stimulated vasovagal syncope during head-up tilt-table test. J Arrhythm. 2017;33 (1):6. doi: 10.1016/j.joa.2016.04.001. PubMed PMID:28217221 PubMed Central PMC5300835.
  2. Kangas, P, Tahvanainen, A, Tikkakoski, A, Koskela, J, Uitto, M, Viik, J et al.. Increased Cardiac Workload in the Upright Posture in Men: Noninvasive Hemodynamics in Men Versus Women. J Am Heart Assoc. 2016;5 (6):. doi: 10.1161/JAHA.115.002883. PubMed PMID:27329447 PubMed Central PMC4937251.
  3. Wilenius, M, Tikkakoski, AJ, Tahvanainen, AM, Haring, A, Koskela, J, Huhtala, H et al.. Central wave reflection is associated with peripheral arterial resistance in addition to arterial stiffness in subjects without antihypertensive medication. BMC Cardiovasc Disord. 2016;16 :131. doi: 10.1186/s12872-016-0303-6. PubMed PMID:27266507 PubMed Central PMC4897906.
  4. Eräranta, A, Tikkakoski, AJ, Pörsti, IH. Mechanisms underlying elevated SBP differ with adiposity in young adults: the Enigma study. J Hypertens. 2016;34 (7):1442-3. doi: 10.1097/HJH.0000000000000937. PubMed PMID:27254147 .
  5. Tahvanainen, AM, Tikkakoski, AJ, Koskela, JK, Nordhausen, K, Viitala, JM, Leskinen, MH et al.. The type of the functional cardiovascular response to upright posture is associated with arterial stiffness: a cross-sectional study in 470 volunteers. BMC Cardiovasc Disord. 2016;16 :101. doi: 10.1186/s12872-016-0281-8. PubMed PMID:27216309 PubMed Central PMC4877753.

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2015

  1. Haltia, O, Törmänen, S, Eräranta, A, Jokihaara, J, Nordhausen, K, Rysä, J et al.. Vasopeptidase Inhibition Corrects the Structure and Function of the Small Arteries in Experimental Renal Insufficiency. J Vasc Res. 2015;52 (2):94-102. doi: 10.1159/000431368. PubMed PMID:26184548 .
  2. Hautaniemi, EJ, Tikkakoski, AJ, Tahvanainen, A, Nordhausen, K, Kähönen, M, Mattsson, T et al.. Effect of fermented milk product containing lactotripeptides and plant sterol esters on haemodynamics in subjects with the metabolic syndrome–a randomised, double-blind, placebo-controlled study. Br J Nutr. 2015;114 (3):376-86. doi: 10.1017/S0007114515002032. PubMed PMID:26168857 .
  3. Kurra, V, Vehmas, T, Eräranta, A, Jokihaara, J, Pirttiniemi, P, Ruskoaho, H et al.. Effects of oxonic acid-induced hyperuricemia on mesenteric artery tone and cardiac load in experimental renal insufficiency. BMC Nephrol. 2015;16 :35. doi: 10.1186/s12882-015-0033-5. PubMed PMID:25886588 PubMed Central PMC4377065.

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2014

  1. Vääräniemi, K, Koskela, J, Tahvanainen, A, Tikkakoski, A, Wilenius, M, Kähönen, M et al.. Lower glomerular filtration rate is associated with higher systemic vascular resistance in patients without prevalent kidney disease. J Clin Hypertens (Greenwich). 2014;16 (10):722-8. doi: 10.1111/jch.12405. PubMed PMID:25228202 PubMed Central PMC8032143.
  2. Leskinen, MH, Hautaniemi, EJ, Tahvanainen, AM, Koskela, JK, Päällysaho, M, Tikkakoski, AJ et al.. Daily liquorice consumption for two weeks increases augmentation index and central systolic and diastolic blood pressure. PLoS One. 2014;9 (8):e105607. doi: 10.1371/journal.pone.0105607. PubMed PMID:25153328 PubMed Central PMC4143270.
  3. Eräranta, A, Törmänen, S, Kööbi, P, Vehmas, TI, Lakkisto, P, Tikkanen, I et al.. Phosphate binding reduces aortic angiotensin-converting enzyme and enhances nitric oxide bioactivity in experimental renal insufficiency. Am J Nephrol. 2014;39 (5):400-8. doi: 10.1159/000362507. PubMed PMID:24818649 .

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2013

  1. Koskela, JK, Tahvanainen, A, Haring, A, Tikkakoski, AJ, Ilveskoski, E, Viitala, J et al.. Association of resting heart rate with cardiovascular function: a cross-sectional study in 522 Finnish subjects. BMC Cardiovasc Disord. 2013;13 :102. doi: 10.1186/1471-2261-13-102. PubMed PMID:24237764 PubMed Central PMC3832902.
  2. Kangas, P, Tikkakoski, AJ, Tahvanainen, AM, Leskinen, MH, Viitala, JM, Kähönen, M et al.. Metabolic syndrome may be associated with increased arterial stiffness even in the absence of hypertension: a study in 84 cases and 82 controls. Metabolism. 2013;62 (8):1114-22. doi: 10.1016/j.metabol.2013.02.009. PubMed PMID:23557592 .
  3. Tikkakoski, AJ, Tahvanainen, AM, Leskinen, MH, Koskela, JK, Haring, A, Viitala, J et al.. Hemodynamic alterations in hypertensive patients at rest and during passive head-up tilt. J Hypertens. 2013;31 (5):906-15. doi: 10.1097/HJH.0b013e32835ed605. PubMed PMID:23412427 .
  4. Smith, P, Tuomisto, MT, Blumenthal, J, Sherwood, A, Parkkinen, L, Kähönen, M et al.. Psychosocial correlates of atrial natriuretic peptide: a marker of vascular health. Ann Behav Med. 2013;45 (1):99-109. doi: 10.1007/s12160-012-9414-1. PubMed PMID:22996638 .

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2012

  1. Eräranta, A, Riutta, A, Fan, M, Koskela, J, Tikkanen, I, Lakkisto, P et al.. Dietary phosphate binding and loading alter kidney angiotensin-converting enzyme mRNA and protein content in 5/6 nephrectomized rats. Am J Nephrol. 2012;35 (5):401-8. doi: 10.1159/000337942. PubMed PMID:22517117 .
  2. Tahvanainen, AM, Tikkakoski, AJ, Leskinen, MH, Nordhausen, K, Kähönen, M, Kööbi, T et al.. Supine and upright haemodynamic effects of sublingual nitroglycerin and inhaled salbutamol: a double-blind, placebo-controlled, randomized study. J Hypertens. 2012;30 (2):297-306. doi: 10.1097/HJH.0b013e32834e4b26. PubMed PMID:22179079 .

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2011

  1. Tahvanainen, A, Koskela, J, Leskinen, M, Ilveskoski, E, Nordhausen, K, Kähönen, M et al.. Reduced systemic vascular resistance in healthy volunteers with presyncopal symptoms during a nitrate-stimulated tilt-table test. Br J Clin Pharmacol. 2011;71 (1):41-51. doi: 10.1111/j.1365-2125.2010.03794.x. PubMed PMID:21143500 PubMed Central PMC3018025.

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2010

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2009

  1. Tahvanainen, A, Leskinen, M, Koskela, J, Ilveskoski, E, Alanko, J, Kähönen, M et al.. Non-invasive measurement of the haemodynamic effects of inhaled salbutamol, intravenous L-arginine and sublingual nitroglycerin. Br J Clin Pharmacol. 2009;68 (1):23-33. doi: 10.1111/j.1365-2125.2009.03434.x. PubMed PMID:19660000 PubMed Central PMC2732937.
  2. Tahvanainen, A, Leskinen, M, Koskela, J, Ilveskoski, E, Nordhausen, K, Oja, H et al.. Ageing and cardiovascular responses to head-up tilt in healthy subjects. Atherosclerosis. 2009;207 (2):445-51. doi: 10.1016/j.atherosclerosis.2009.06.001. PubMed PMID:19580971 .
  3. Kurra, V, Eräranta, A, Jolma, P, Vehmas, TI, Riutta, A, Moilanen, E et al.. Hyperuricemia, oxidative stress, and carotid artery tone in experimental renal insufficiency. Am J Hypertens. 2009;22 (9):964-70. doi: 10.1038/ajh.2009.109. PubMed PMID:19521342 .
  4. Eräranta, A, Lakkisto, PJ, Tikkanen, I, Mustonen, JT, Pörsti, IH. Paricalcitol and renin-angiotensin components in remnant kidneys. Kidney Int. 2009;75 (3):339-40; author reply 340. doi: 10.1038/ki.2008.593. PubMed PMID:19148159 .
  5. Tahvanainen, A, Koskela, J, Tikkakoski, A, Lahtela, J, Leskinen, M, Kähönen, M et al.. Analysis of cardiovascular responses to passive head-up tilt using continuous pulse wave analysis and impedance cardiography. Scand J Clin Lab Invest. 2009;69 (1):128-37. doi: 10.1080/00365510802439098. PubMed PMID:18850486 .

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2008

  1. Pörsti, IH. Expanding targets of vitamin D receptor activation: downregulation of several RAS components in the kidney. Kidney Int. 2008;74 (11):1371-3. doi: 10.1038/ki.2008.424. PubMed PMID:19008907 .
  2. Eräranta, A, Kurra, V, Tahvanainen, AM, Vehmas, TI, Kööbi, P, Lakkisto, P et al.. Oxonic acid-induced hyperuricemia elevates plasma aldosterone in experimental renal insufficiency. J Hypertens. 2008;26 (8):1661-8. doi: 10.1097/HJH.0b013e328303205d. PubMed PMID:18622246 .
  3. Kaartinen, K, Syrjänen, J, Pörsti, I, Hurme, M, Harmoinen, A, Pasternack, A et al.. Inflammatory markers and the progression of IgA glomerulonephritis. Nephrol Dial Transplant. 2008;23 (4):1285-90. doi: 10.1093/ndt/gfm782. PubMed PMID:17986475 .

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2007

  1. Kaartinen, K, Syrjänen, J, Pörsti, I, Hurme, M, Harmoinen, A, Pasternack, A et al.. Inflammatory markers and the progression of IgA glomerulonephritis. Nephrol Dial Transplant. 2008;23 (4):1285-90. doi: 10.1093/ndt/gfm782. PubMed PMID:17986475 .
  2. Fan, M, Raitakari, OT, Kähönen, M, Juonala, M, Hutri-Kähönen, N, Marniemi, J et al.. CYBA C242T gene polymorphism and flow-mediated vasodilation in a population of young adults: the Cardiovascular Risk in Young Finns Study. J Hypertens. 2007;25 (7):1381-7. doi: 10.1097/HJH.0b013e32810bfe58. PubMed PMID:17563559 .

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2006

  1. Tahvanainen, A, Taurio, J, Mäki-Jouppi, J, Kööbi, P, Mustonen, J, Kähönen, M et al.. Increased wall tension in response to vasoconstrictors in isolated mesenteric arterial rings from patients with high blood pressure. Basic Clin Pharmacol Toxicol. 2006;99 (6):440-9. doi: 10.1111/j.1742-7843.2006.pto_572.x. PubMed PMID:17169125 .
  2. Kööbi, P, Vehmas, TI, Jolma, P, Kalliovalkama, J, Fan, M, Niemelä, O et al.. High-calcium vs high-phosphate intake and small artery tone in advanced experimental renal insufficiency. Nephrol Dial Transplant. 2006;21 (10):2754-61. doi: 10.1093/ndt/gfl270. PubMed PMID:16837509 .

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