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Intestinal Signalling and Epigenetics (ISE)

Group members

GROUP MEMBERS

Keijo ViiriThe ISE group is led by Adjunct Professor Keijo Viiri, who earned his PhD from the University of Tampere in 2009. He completed his postdoctoral research at University College London’s Cancer Institute in the UK from 2009 to 2013. In 2017, he established his own research group as an Academy Research Fellow and is currently the head of the Laboratory Unit at the Faculty of Medicine and Health Technology.

Hana Le (Postdoc)

Hana Le

Hana Le researchHana has obtained her MSc degree from Chung Ang University, South Korea and PhD degree in 2023 at Tampere University with Molecular Signaling group. She is engaged in celiac disease research in ISE group, focusing particularly on evaluating intestinal health through spatial transcriptomic tools. Hana also contributes to EU-funded projects, where our lab leads work packages for HEDIMED and ENT1DEP consortia. These projects involve investigating the role of viral infections in triggering celiac disease, utilizing methods such as enterovirus infection on human intestinal organoids followed by single-cell RNA sequencing (scRNA-seq).

Valeriia Dotsenko (Postdoc)

Valeriia Dotsenko research

Valeriia Dotsenko researchValeriia has obtained her MSc from Taras Shevchenko National University of Kyiv.  She completed her PhD thesis in 2024 with the ISE group https://trepo.tuni.fi/handle/10024/159152. Currently, she is a postdoctoral researcher, continuing the work in transglutaminase 2-inhibitor, ZED1227, drug trial studies accompanied with the transcriptomic assessment of the drug efficacy. Additionally, she is involved in other EU-funded celiac disease research projects, such as establishing an air-liquid organoid system for virus infection studies.

Laura Martin Diaz (PhD student)

Laura Martin Diaz Laura Diaz researchLaura has obtained her MSc degree from University of Alcalá (Madrid, Spain). Her PhD project focuses on investigating a newly discovered mechanism in hormone secretion (GLP-1 and insulin) and its related endocrine signalling for glycaemic control. She employs transgenic in vivo mouse models, as well as in vitro organoid, tissue culture, and explant systems. Additionally, she aims to identify novel drug compounds with potential for glycaemic control.

Roselia Davidsson (PhD student)

Roselia Davidsson Roselia Davidsson researchRoselia has obtained her MSc degree from University of Helsinki. Her PhD project aims to unravel the mechanisms by which epigenetic histone modifications translate metabolic and inflammatory signals into epithelial cell homeostasis. The ultimate goal is to understand how these processes become dysregulated in celiac disease and to identify biological targets for medical intervention.

Lab Alumni