2024
- Moulder, R, Bhosale, SD, Viiri, K, Lahesmaa, R. Comparative proteomics analysis of the mouse mini-gut organoid: insights into markers of gluten challenge from celiac disease intestinal biopsies. Front Mol Biosci. 2024;11 :1446822. doi: 10.3389/fmolb.2024.1446822. PubMed PMID:39263374 PubMed Central PMC11387180.
- Dotsenko, V, Tewes, B, Hils, M, Pasternack, R, Isola, J, Taavela, J et al.. Transcriptomic analysis of intestine following administration of a transglutaminase 2 inhibitor to prevent gluten-induced intestinal damage in celiac disease. Nat Immunol. 2024;25 (7):1218-1230. doi: 10.1038/s41590-024-01867-0. PubMed PMID:38914866 PubMed Central PMC11224021.
- Hakola, L, Lund-Blix, NA, Takkinen, HM, Tapanainen, H, Niinistö, S, Korhonen, TE et al.. Maternal gluten, cereal, and dietary fiber intake during pregnancy and lactation and the risk of islet autoimmunity and type 1 diabetes in the child. Clin Nutr ESPEN. 2024;62 :22-27. doi: 10.1016/j.clnesp.2024.05.001. PubMed PMID:38901945 .
2023
- Dotsenko, V, Sioofy-Khojine, AB, Hyöty, H, Viiri, K. Human intestinal organoid models for celiac disease research. Methods Cell Biol. 2023;179 :173-193. doi: 10.1016/bs.mcb.2023.01.008. PubMed PMID:37625874 .
- Isola, J, Mäki, M, Hils, M, Pasternack, R, Viiri, K, Dotsenko, V et al.. The Oral Transglutaminase 2 Inhibitor ZED1227 Accumulates in the Villous Enterocytes in Celiac Disease Patients during Gluten Challenge and Drug Treatment. Int J Mol Sci. 2023;24 (13):. doi: 10.3390/ijms241310815. PubMed PMID:37445994 PubMed Central PMC10341493.
2022
- Mattola, S, Mäntylä, E, Aho, V, Salminen, S, Leclerc, S, Oittinen, M et al.. G2/M checkpoint regulation and apoptosis facilitate the nuclear egress of parvoviral capsids. Front Cell Dev Biol. 2022;10 :1070599. doi: 10.3389/fcell.2022.1070599. PubMed PMID:36568985 PubMed Central PMC9773396.
- Tavares, M, Khandelwal, G, Muter, J, Viiri, K, Beltran, M, Brosens, JJ et al.. JAZF1-SUZ12 dysregulates PRC2 function and gene expression during cell differentiation. Cell Rep. 2022;39 (9):110889. doi: 10.1016/j.celrep.2022.110889. PubMed PMID:35649353 PubMed Central PMC9637993.
2019-2021
- Stenvall, CA, Tayyab, M, Grönroos, TJ, Ilomäki, MA, Viiri, K, Ridge, KM et al.. Targeted deletion of keratin 8 in intestinal epithelial cells disrupts tissue integrity and predisposes to tumorigenesis in the colon. Cell Mol Life Sci. 2021;79 (1):10. doi: 10.1007/s00018-021-04081-5. PubMed PMID:34951664 PubMed Central PMC8709826.
- George, JJ, Martin-Diaz, L, Ojanen, MJT, Gasa, R, Pesu, M, Viiri, K et al.. PRC2 Regulated Atoh8 Is a Regulator of Intestinal Microfold Cell (M Cell) Differentiation. Int J Mol Sci. 2021;22 (17):. doi: 10.3390/ijms22179355. PubMed PMID:34502262 PubMed Central PMC8431250.
- Taavela, J, Viiri, K, Välimäki, A, Sarin, J, Salonoja, K, Mäki, M et al.. Apolipoprotein A4 Defines the Villus-Crypt Border in Duodenal Specimens for Celiac Disease Morphometry. Front Immunol. 2021;12 :713854. doi: 10.3389/fimmu.2021.713854. PubMed PMID:34394117 PubMed Central PMC8358775.
- George, JJ, Oittinen, M, Martin-Diaz, L, Zapilko, V, Iqbal, S, Rintakangas, T et al.. Polycomb Repressive Complex 2 Regulates Genes Necessary for Intestinal Microfold Cell (M Cell) Development. Cell Mol Gastroenterol Hepatol. 2021;12 (3):873-889. doi: 10.1016/j.jcmgh.2021.05.014. PubMed PMID:34058415 PubMed Central PMC8346665.
- Dotsenko, V, Oittinen, M, Taavela, J, Popp, A, Peräaho, M, Staff, S et al.. Genome-Wide Transcriptomic Analysis of Intestinal Mucosa in Celiac Disease Patients on a Gluten-Free Diet and Postgluten Challenge. Cell Mol Gastroenterol Hepatol. 2021;11 (1):13-32. doi: 10.1016/j.jcmgh.2020.07.010. PubMed PMID:32745639 PubMed Central PMC7593586.
- Dotsenko, V, Oittinen, M, Taavela, J, Popp, A, Peräaho, M, Staff, S et al.. Genome-Wide Transcriptomic Analysis of Intestinal Mucosa in Celiac Disease Patients on a Gluten-Free Diet and Postgluten Challenge. Cell Mol Gastroenterol Hepatol. 2021;11 (1):13-32. doi: 10.1016/j.jcmgh.2020.07.010. PubMed PMID:32745639 PubMed Central PMC7593586.
- Taavela, J, Viiri, K, Popp, A, Oittinen, M, Dotsenko, V, Peräaho, M et al.. Histological, immunohistochemical and mRNA gene expression responses in coeliac disease patients challenged with gluten using PAXgene fixed paraffin-embedded duodenal biopsies. BMC Gastroenterol. 2019;19 (1):189. doi: 10.1186/s12876-019-1089-7. PubMed PMID:31730447 PubMed Central PMC6858741.
- Cellier, C, Bouma, G, van Gils, T, Khater, S, Malamut, G, Crespo, L et al.. Safety and efficacy of AMG 714 in patients with type 2 refractory coeliac disease: a phase 2a, randomised, double-blind, placebo-controlled, parallel-group study. Lancet Gastroenterol Hepatol. 2019;4 (12):960-970. doi: 10.1016/S2468-1253(19)30265-1. PubMed PMID:31494097 .
- Vattulainen, M, Ilmarinen, T, Koivusalo, L, Viiri, K, Hongisto, H, Skottman, H et al.. Modulation of Wnt/BMP pathways during corneal differentiation of hPSC maintains ABCG2-positive LSC population that demonstrates increased regenerative potential. Stem Cell Res Ther. 2019;10 (1):236. doi: 10.1186/s13287-019-1354-2. PubMed PMID:31383008 PubMed Central PMC6683518.
- Viiri, LE, Rantapero, T, Kiamehr, M, Alexanova, A, Oittinen, M, Viiri, K et al.. Extensive reprogramming of the nascent transcriptome during iPSC to hepatocyte differentiation. Sci Rep. 2019;9 (1):3562. doi: 10.1038/s41598-019-39215-0. PubMed PMID:30837492 PubMed Central PMC6401154.