2025
- Lipponen, A, Luomala, O, Juutinen, A, Hokajärvi, AM, Kolehmainen, A, Oksanen, J et al.. Development of an online portal for wastewater-based surveillance of multiple pathogens – A WastPan Study. Environ Int. 2025;200 :109545. doi: 10.1016/j.envint.2025.109545. PubMed PMID:40414187 .
- Peterson, C, Tagoma, A, Alnek, K, Bärenson, A, Vorobjova, T, Talja, I et al.. Antibodies against in the children of mothers at risk for gestational diabetes. Immunol Med. 2025; :1-11. doi: 10.1080/25785826.2025.2504021. PubMed PMID:40406906 .
- Länsivaara, A, Palmroth, M, Kaarela, O, Hyöty, H, Oikarinen, S, Lehto, KM et al.. Virus detection in influent, activated sludge, and effluent from municipal wastewater treatment plants using composite and grab samples in Finland. Environ Res. 2025;279 (Pt 2):121776. doi: 10.1016/j.envres.2025.121776. PubMed PMID:40324624 .
- Rewers, M, Agardh, D, Johnson, SB, Bonifacio, E, Larsson, HE, Gesualdo, P et al.. Unfolding the Mystery of Autoimmunity: The Environmental Determinants of Diabetes in the Young (TEDDY) Study. Diabetes Care. 2025; :. doi: 10.2337/dc24-2886. PubMed PMID:40272272 .
- Soppela, S, Plavec, Z, Gröhn, S, Mustonen, I, Jartti, M, Oikarinen, S et al.. Immunological and structural evaluation of the intranasally administrated CVB1 whole-virus and VLP vaccines. Sci Rep. 2025;15 (1):10198. doi: 10.1038/s41598-025-94656-0. PubMed PMID:40133550 PubMed Central PMC11937443.
- Laiho, JE, Oikarinen, S, Morfopoulou, S, Oikarinen, M, Renner, A, Depledge, D et al.. Detection of enterovirus RNA in pancreas and lymphoid tissues of organ donors with type 1 diabetes. Diabetologia. 2025;68 (6):1211-1225. doi: 10.1007/s00125-025-06359-w. PubMed PMID:40095061 PubMed Central PMC12069483.
- Al-Mustapha, AI, Tiwari, A, Laukkanen-Ninios, R, Lehto, KM, Oikarinen, S, Lipponen, A et al.. Wastewater based genomic surveillance key to population level monitoring of AmpC/ESBL producing Escherichia coli. Sci Rep. 2025;15 (1):7400. doi: 10.1038/s41598-025-91516-9. PubMed PMID:40033002 PubMed Central PMC11876440.
- Jonsdottir, B, Clasen, JL, Vehik, K, Lernmark, Å, Lundgren, M, Bonifacio, E et al.. Early Appearance of Thyroid Autoimmunity in Children Followed From Birth for Type 1 Diabetes Risk. J Clin Endocrinol Metab. 2025;110 (2):498-510. doi: 10.1210/clinem/dgae478. PubMed PMID:38996042 PubMed Central PMC11747670.
2024
- Eurén, A, Lynch, K, Lindfors, K, Parikh, H, Koletzko, S, Liu, E et al.. Risk of celiac disease autoimmunity is modified by interactions between CD247 and environmental exposures. Sci Rep. 2024;14 (1):25463. doi: 10.1038/s41598-024-75496-w. PubMed PMID:39462122 PubMed Central PMC11567144.
- Laiho, JE, Oikarinen, S, Morfopoulou, S, Oikarinen, M, Renner, A, Depledge, D et al.. Detection of enterovirus RNA in pancreas and lymphoid tissues of organ donors with type 1 diabetes. medRxiv. 2024; :. doi: 10.1101/2024.09.11.24313112. PubMed PMID:39314969 PubMed Central PMC11419248.
- Parajuli, A, Mäkelä, I, Roslund, MI, Ringqvist, E, Manninen, J, Sun, Y et al.. Production, analysis, and safety assessment of a soil and plant-based natural material with microbiome- and immune-modulatory effects. Methods. 2024;231 :94-102. doi: 10.1016/j.ymeth.2024.09.011. PubMed PMID:39306218 .
- Al-Mustapha, AI, Tiwari, A, Johansson, V, Heljanko, V, Kirsi-Maarit, L, Lipponen, A et al.. Characterization of methicillin resistant in municipal wastewater in Finland. One Health. 2024;19 :100881. doi: 10.1016/j.onehlt.2024.100881. PubMed PMID:39263321 PubMed Central PMC11388770.
- Sarekoski, A, Lipponen, A, Hokajärvi, AM, Räisänen, K, Tiwari, A, Paspaliari, D et al.. Simultaneous biomass concentration and subsequent quantitation of multiple infectious disease agents and antimicrobial resistance genes from community wastewater. Environ Int. 2024;191 :108973. doi: 10.1016/j.envint.2024.108973. PubMed PMID:39182255 .
- Länsivaara, A, Lehto, KM, Hyder, R, Janhonen, ES, Lipponen, A, Heikinheimo, A et al.. Comparison of Different Reverse Transcriptase-Polymerase Chain Reaction-Based Methods for Wastewater Surveillance of SARS-CoV-2: Exploratory Study. JMIR Public Health Surveill. 2024;10 :e53175. doi: 10.2196/53175. PubMed PMID:39158943 PubMed Central PMC11369532.
- Roslund, MI, Nurminen, N, Oikarinen, S, Puhakka, R, Grönroos, M, Puustinen, L et al.. Skin exposure to soil microbiota elicits changes in cell-mediated immunity to pneumococcal vaccine. Sci Rep. 2024;14 (1):18573. doi: 10.1038/s41598-024-68235-8. PubMed PMID:39127736 PubMed Central PMC11316737.
- Soppela, S, Plavec, Z, Gröhn, S, Jartti, M, Oikarinen, S, Laajala, M et al.. Comparison of structure and immunogenicity of CVB1-VLP and inactivated CVB1 vaccine candidates. Res Sq. 2024; :. doi: 10.21203/rs.3.rs-4545395/v1. PubMed PMID:38978565 PubMed Central PMC11230480.
- Hakola, L, Lund-Blix, NA, Takkinen, HM, Tapanainen, H, Niinistö, S, Korhonen, TE et al.. Maternal gluten, cereal, and dietary fiber intake during pregnancy and lactation and the risk of islet autoimmunity and type 1 diabetes in the child. Clin Nutr ESPEN. 2024;62 :22-27. doi: 10.1016/j.clnesp.2024.05.001. PubMed PMID:38901945 .
- Lehto, KM, Länsivaara, A, Hyder, R, Luomala, O, Lipponen, A, Hokajärvi, AM et al.. Wastewater-based surveillance is an efficient monitoring tool for tracking influenza A in the community. Water Res. 2024;257 :121650. doi: 10.1016/j.watres.2024.121650. PubMed PMID:38692254 .
- Lipponen, A, Kolehmainen, A, Oikarinen, S, Hokajärvi, AM, Lehto, KM, Heikinheimo, A et al.. Detection of SARS-COV-2 variants and their proportions in wastewater samples using next-generation sequencing in Finland. Sci Rep. 2024;14 (1):7751. doi: 10.1038/s41598-024-58113-8. PubMed PMID:38565591 PubMed Central PMC10987589.
- Tiwari, A, Lehto, KM, Paspaliari, DK, Al-Mustapha, AI, Sarekoski, A, Hokajärvi, AM et al.. Developing wastewater-based surveillance schemes for multiple pathogens: The WastPan project in Finland. Sci Total Environ. 2024;926 :171401. doi: 10.1016/j.scitotenv.2024.171401. PubMed PMID:38467259 .
- Hakola, L, Mramba, LK, Uusitalo, U, Andrén Aronsson, C, Hummel, S, Niinistö, S et al.. Intake of B vitamins and the risk of developing islet autoimmunity and type 1 diabetes in the TEDDY study. Eur J Nutr. 2024;63 (4):1329-1338. doi: 10.1007/s00394-024-03346-6. PubMed PMID:38413484 PubMed Central PMC11139689.
- Hyöty, H, Kääriäinen, S, Laiho, JE, Comer, GM, Tian, W, Härkönen, T et al.. Safety, tolerability and immunogenicity of PRV-101, a multivalent vaccine targeting coxsackie B viruses (CVBs) associated with type 1 diabetes: a double-blind randomised placebo-controlled Phase I trial. Diabetologia. 2024;67 (5):811-821. doi: 10.1007/s00125-024-06092-w. PubMed PMID:38369573 PubMed Central PMC10954874.
- Heljanko, V, Tyni, O, Johansson, V, Virtanen, JP, Räisänen, K, Lehto, KM et al.. Clinically relevant sequence types of carbapenemase-producing Escherichia coli and Klebsiella pneumoniae detected in Finnish wastewater in 2021-2022. Antimicrob Resist Infect Control. 2024;13 (1):14. doi: 10.1186/s13756-024-01370-z. PubMed PMID:38291521 PubMed Central PMC10829384.
2023
2022
- Tiwari, A, Kurittu, P, Al-Mustapha, AI, Heljanko, V, Johansson, V, Thakali, O et al.. Wastewater surveillance of antibiotic-resistant bacterial pathogens: A systematic review. Front Microbiol. 2022;13 :977106. doi: 10.3389/fmicb.2022.977106. PubMed PMID:36590429 PubMed Central PMC9798455.
- Vatanen, T, Jabbar, KS, Ruohtula, T, Honkanen, J, Avila-Pacheco, J, Siljander, H et al.. Mobile genetic elements from the maternal microbiome shape infant gut microbial assembly and metabolism. Cell. 2022;185 (26):4921-4936.e15. doi: 10.1016/j.cell.2022.11.023. PubMed PMID:36563663 PubMed Central PMC9869402.
- Tiwari, A, Adhikari, S, Kaya, D, Islam, MA, Malla, B, Sherchan, SP et al.. Monkeypox outbreak: Wastewater and environmental surveillance perspective. Sci Total Environ. 2023;856 (Pt 2):159166. doi: 10.1016/j.scitotenv.2022.159166. PubMed PMID:36202364 PubMed Central PMC9534267.
- Vehik, K, Boulware, D, Killian, M, Rewers, M, McIndoe, R, Toppari, J et al.. Rising Hemoglobin A1c in the Nondiabetic Range Predicts Progression of Type 1 Diabetes As Well As Oral Glucose Tolerance Tests. Diabetes Care. 2022;45 (10):2342-2349. doi: 10.2337/dc22-0828. PubMed PMID:36150054 PubMed Central PMC9587339.
- Krischer, JP, Liu, X, Lernmark, Å, Hagopian, WA, Rewers, MJ, She, JX et al.. Predictors of the Initiation of Islet Autoimmunity and Progression to Multiple Autoantibodies and Clinical Diabetes: The TEDDY Study. Diabetes Care. 2022;45 (10):2271-2281. doi: 10.2337/dc21-2612. PubMed PMID:36150053 PubMed Central PMC9643148.
- Luoma, J, Adubra, L, Ashorn, P, Ashorn, U, Bendabenda, J, Dewey, KG et al.. Association between asymptomatic infections and linear growth in 18-24-month-old Malawian children. Matern Child Nutr. 2023;19 (1):e13417. doi: 10.1111/mcn.13417. PubMed PMID:36111423 PubMed Central PMC9749610.
- Roslund, MI, Parajuli, A, Hui, N, Puhakka, R, Grönroos, M, Soininen, L et al.. A Placebo-controlled double-blinded test of the biodiversity hypothesis of immune-mediated diseases: Environmental microbial diversity elicits changes in cytokines and increase in T regulatory cells in young children. Ecotoxicol Environ Saf. 2022;242 :113900. doi: 10.1016/j.ecoenv.2022.113900. PubMed PMID:35930838 .
- Sioofy-Khojine, AB, Richardson, SJ, Locke, JM, Oikarinen, S, Nurminen, N, Laine, AP et al.. Detection of enterovirus RNA in peripheral blood mononuclear cells correlates with the presence of the predisposing allele of the type 1 diabetes risk gene IFIH1 and with disease stage. Diabetologia. 2022;65 (10):1701-1709. doi: 10.1007/s00125-022-05753-y. PubMed PMID:35867130 PubMed Central PMC9477938.
- Tiwari, A, Ahmed, W, Oikarinen, S, Sherchan, SP, Heikinheimo, A, Jiang, G et al.. Application of digital PCR for public health-related water quality monitoring. Sci Total Environ. 2022;837 :155663. doi: 10.1016/j.scitotenv.2022.155663. PubMed PMID:35523326 .
- Välikangas, T, Lietzén, N, Jaakkola, MK, Krogvold, L, Eike, MC, Kallionpää, H et al.. Pancreas Whole Tissue Transcriptomics Highlights the Role of the Exocrine Pancreas in Patients With Recently Diagnosed Type 1 Diabetes. Front Endocrinol (Lausanne). 2022;13 :861985. doi: 10.3389/fendo.2022.861985. PubMed PMID:35498413 PubMed Central PMC9044038.
- Soininen, L, Roslund, MI, Nurminen, N, Puhakka, R, Laitinen, OH, Hyöty, H et al.. Indoor green wall affects health-associated commensal skin microbiota and enhances immune regulation: a randomized trial among urban office workers. Sci Rep. 2022;12 (1):6518. doi: 10.1038/s41598-022-10432-4. PubMed PMID:35444249 PubMed Central PMC9021224.
- Hård Af Segerstad, EM, Liu, X, Uusitalo, U, Agardh, D, Andrén Aronsson, C, TEDDY Study Group et al.. Sources of dietary gluten in the first 2 years of life and associations with celiac disease autoimmunity and celiac disease in Swedish genetically predisposed children: The Environmental Determinants of Diabetes in the Young (TEDDY) study. Am J Clin Nutr. 2022;116 (2):394-403. doi: 10.1093/ajcn/nqac086. PubMed PMID:35394004 PubMed Central PMC9348971.
- Törn, C, Liu, X, Onengut-Gumuscu, S, Counts, KM, Moreno, JL, Remedios, CL et al.. Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study. Sci Rep. 2022;12 (1):4516. doi: 10.1038/s41598-022-08058-7. PubMed PMID:35296692 PubMed Central PMC8927592.
- Ferrat, LA, Vehik, K, Sharp, SA, Lernmark, Å, Rewers, MJ, She, JX et al.. Author Correction: A combined risk score enhances prediction of type 1 diabetes among susceptible children. Nat Med. 2022;28 (3):599. doi: 10.1038/s41591-021-01631-z. PubMed PMID:35165454 .
- Jacobsen, LM, Vehik, K, Veijola, R, Warncke, K, Toppari, J, Steck, AK et al.. Heterogeneity of DKA Incidence and Age-Specific Clinical Characteristics in Children Diagnosed With Type 1 Diabetes in the TEDDY Study. Diabetes Care. 2022;45 (3):624-633. doi: 10.2337/dc21-0422. PubMed PMID:35043162 PubMed Central PMC8918232.
- Melin, J, Lynch, KF, Lundgren, M, Aronsson, CA, Larsson, HE, Johnson, SB et al.. Is staff consistency important to parents’ satisfaction in a longitudinal study of children at risk for type 1 diabetes: the TEDDY study. BMC Endocr Disord. 2022;22 (1):19. doi: 10.1186/s12902-021-00929-w. PubMed PMID:35012530 PubMed Central PMC8744326.
- González-Rodríguez, MI, Nurminen, N, Kummola, L, Laitinen, OH, Oikarinen, S, Parajuli, A et al.. Effect of inactivated nature-derived microbial composition on mouse immune system. Immun Inflamm Dis. 2022;10 (3):e579. doi: 10.1002/iid3.579. PubMed PMID:34873877 PubMed Central PMC8926502.
2021
- González-Rodríguez, MI, Nurminen, N, Kummola, L, Laitinen, OH, Oikarinen, S, Parajuli, A et al.. Effect of inactivated nature-derived microbial composition on mouse immune system. Immun Inflamm Dis. 2022;10 (3):e579. doi: 10.1002/iid3.579. PubMed PMID:34873877 PubMed Central PMC8926502.
- Brænne, I, Onengut-Gumuscu, S, Chen, R, Manichaikul, AW, Rich, SS, Chen, WM et al.. Dynamic changes in immune gene co-expression networks predict development of type 1 diabetes. Sci Rep. 2021;11 (1):22651. doi: 10.1038/s41598-021-01840-z. PubMed PMID:34811390 PubMed Central PMC8609030.
- Roslund, MI, Puhakka, R, Nurminen, N, Oikarinen, S, Siter, N, Grönroos, M et al.. Long-term biodiversity intervention shapes health-associated commensal microbiota among urban day-care children. Environ Int. 2021;157 :106811. doi: 10.1016/j.envint.2021.106811. PubMed PMID:34403882 .
- Oikarinen, S, Krogvold, L, Edwin, B, Buanes, T, Korsgren, O, Laiho, JE et al.. Characterisation of enterovirus RNA detected in the pancreas and other specimens of live patients with newly diagnosed type 1 diabetes in the DiViD study. Diabetologia. 2021;64 (11):2491-2501. doi: 10.1007/s00125-021-05525-0. PubMed PMID:34390364 PubMed Central PMC8494699.
- Cinek, O, Polackova, K, Odeh, R, Alassaf, A, Kramná, L, Ibekwe, MU et al.. Blastocystis in the faeces of children from six distant countries: prevalence, quantity, subtypes and the relation to the gut bacteriome. Parasit Vectors. 2021;14 (1):399. doi: 10.1186/s13071-021-04859-3. PubMed PMID:34384477 PubMed Central PMC8359624.
- Mohanraj, U, Jokinen, M, Thapa, RR, Paloniemi, M, Vesikari, T, Lappalainen, M et al.. Human Protoparvovirus DNA and IgG in Children and Adults with and without Respiratory or Gastrointestinal Infections. Viruses. 2021;13 (3):. doi: 10.3390/v13030483. PubMed PMID:33804173 PubMed Central PMC7999311.
- Ruohtula, T, Kondrashova, A, Lehtonen, J, Oikarinen, S, Hämäläinen, AM, Niemelä, O et al.. Immunomodulatory Effects of Rhinovirus and Enterovirus Infections During the First Year of Life. Front Immunol. 2020;11 :567046. doi: 10.3389/fimmu.2020.567046. PubMed PMID:33643278 PubMed Central PMC7905218.
- Bonifacio, E, Weiß, A, Winkler, C, Hippich, M, Rewers, MJ, Toppari, J et al.. An Age-Related Exponential Decline in the Risk of Multiple Islet Autoantibody Seroconversion During Childhood. Diabetes Care. 2021;44 (10):2260-8. doi: 10.2337/dc20-2122. PubMed PMID:33627366 PubMed Central PMC8929192.
- Hokajärvi, AM, Rytkönen, A, Tiwari, A, Kauppinen, A, Oikarinen, S, Lehto, KM et al.. The detection and stability of the SARS-CoV-2 RNA biomarkers in wastewater influent in Helsinki, Finland. Sci Total Environ. 2021;770 :145274. doi: 10.1016/j.scitotenv.2021.145274. PubMed PMID:33513496 PubMed Central PMC7825999.
- Maleta, K, Fan, YM, Luoma, J, Ashorn, U, Bendabenda, J, Dewey, KG et al.. Infections and systemic inflammation are associated with lower plasma concentration of insulin-like growth factor I among Malawian children. Am J Clin Nutr. 2021;113 (2):380-390. doi: 10.1093/ajcn/nqaa327. PubMed PMID:33381802 PubMed Central PMC7851819.
- Vari, HK, Roslund, MI, Oikarinen, S, Nurminen, N, Puhakka, R, Parajuli, A et al.. Associations between land cover categories, gaseous PAH levels in ambient air and endocrine signaling predicted from gut bacterial metagenome of the elderly. Chemosphere. 2021;265 :128965. doi: 10.1016/j.chemosphere.2020.128965. PubMed PMID:33248729 .
- Liu, Z, Fan, YM, Ashorn, P, Cheung, YB, Hallamaa, L, Hyöty, H et al.. Faecal regenerating 1B protein concentration is not associated with child growth in rural Malawi. J Paediatr Child Health. 2021;57 (3):388-394. doi: 10.1111/jpc.15231. PubMed PMID:33112481 PubMed Central PMC8048694.
2020
2019
- Lindfors, K, Lin, J, Lee, HS, Hyöty, H, Nykter, M, Kurppa, K et al.. Metagenomics of the faecal virome indicate a cumulative effect of enterovirus and gluten amount on the risk of coeliac disease autoimmunity in genetically at risk children: the TEDDY study. Gut. 2020;69 (8):1416-1422. doi: 10.1136/gutjnl-2019-319809. PubMed PMID:31744911 PubMed Central PMC7234892.
- Johnson, RK, Vanderlinden, L, DeFelice, BC, Kechris, K, Uusitalo, U, Fiehn, O et al.. Metabolite-related dietary patterns and the development of islet autoimmunity. Sci Rep. 2019;9 (1):14819. doi: 10.1038/s41598-019-51251-4. PubMed PMID:31616039 PubMed Central PMC6794249.
- Lietzén, N, Hirvonen, K, Honkimaa, A, Buchacher, T, Laiho, JE, Oikarinen, S et al.. Coxsackievirus B Persistence Modifies the Proteome and the Secretome of Pancreatic Ductal Cells. iScience. 2019;19 :340-357. doi: 10.1016/j.isci.2019.07.040. PubMed PMID:31404834 PubMed Central PMC6699423.
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- Roslund, MI, Rantala, S, Oikarinen, S, Puhakka, R, Hui, N, Parajuli, A et al.. Endocrine disruption and commensal bacteria alteration associated with gaseous and soil PAH contamination among daycare children. Environ Int. 2019;130 :104894. doi: 10.1016/j.envint.2019.06.004. PubMed PMID:31220749 .
- Mustonen, N, Siljander, H, Peet, A, Tillmann, V, Härkönen, T, Ilonen, J et al.. Early childhood infections and the use of antibiotics and antipyretic-analgesics in Finland, Estonia and Russian Karelia. Acta Paediatr. 2019;108 (11):2075-2082. doi: 10.1111/apa.14874. PubMed PMID:31132164 .
- Lehto, KM, Fan, YM, Oikarinen, S, Nurminen, N, Hallamaa, L, Juuti, R et al.. Presence of Giardia lamblia in stools of six- to 18-month old asymptomatic Malawians is associated with children’s growth failure. Acta Paediatr. 2019;108 (10):1833-1840. doi: 10.1111/apa.14832. PubMed PMID:31038225 PubMed Central PMC6790611.
- Krischer, JP, Liu, X, Vehik, K, Akolkar, B, Hagopian, WA, Rewers, MJ et al.. Predicting Islet Cell Autoimmunity and Type 1 Diabetes: An 8-Year TEDDY Study Progress Report. Diabetes Care. 2019;42 (6):1051-1060. doi: 10.2337/dc18-2282. PubMed PMID:30967432 PubMed Central PMC6609953.
- Korhonen, L, Oikarinen, S, Lehtonen, J, Mustonen, N, Tyni, I, Niemelä, O et al.. Rhinoviruses in infancy and risk of immunoglobulin E sensitization. J Med Virol. 2019;91 (8):1470-1478. doi: 10.1002/jmv.25455. PubMed PMID:30866076 .