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Laboratory of Regenerative Medicine

Publications

2024

  1. Pedret, C, Peña-Amaro, J, Balius, R, Järvinen, T. Histological Definition of Skeletal Muscle Injury: A Guide to Nomenclature Along the Connective Tissue Sheath/Structure. Sports Med. 2024; :. doi: 10.1007/s40279-024-02165-3. PubMed PMID:39692975 .
  2. Komulainen, T, Daymond, P, Hietanen, KE, Kaartinen, IS, Järvinen, TAH. Myofibroblasts reside in the middle dermis of the keloids but do not predict the response to injection therapies: a double-blinded, randomized, controlled trial. Front Med (Lausanne). 2024;11 :1293028. doi: 10.3389/fmed.2024.1293028. PubMed PMID:38495113 PubMed Central PMC10943694.
  3. Maldonado, H, Savage, BD, Barker, HR, May, U, Vähätupa, M, Badiani, RK et al.. Author Correction: Systemically administered wound-homing peptide accelerates wound healing by modulating syndecan-4 function. Nat Commun. 2024;15 (1):234. doi: 10.1038/s41467-023-44574-4. PubMed PMID:38172142 PubMed Central PMC10764947.

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2023

  1. Maldonado, H, Savage, BD, Barker, HR, May, U, Vähätupa, M, Badiani, RK et al.. Systemically administered wound-homing peptide accelerates wound healing by modulating syndecan-4 function. Nat Commun. 2023;14 (1):8069. doi: 10.1038/s41467-023-43848-1. PubMed PMID:38057316 PubMed Central PMC10700342.
  2. Edouard, P, Reurink, G, Mackey, AL, Lieber, RL, Pizzari, T, Järvinen, TAH et al.. Traumatic muscle injury. Nat Rev Dis Primers. 2023;9 (1):56. doi: 10.1038/s41572-023-00469-8. PubMed PMID:37857686 .
  3. Salomaa, T, Kummola, L, González-Rodríguez, MI, Hiihtola, L, Järvinen, TAH, Junttila, IS et al.. Low IL-13Rα1 expression on mast cells tunes them unresponsive to IL-13. J Leukoc Biol. 2023;114 (2):187-194. doi: 10.1093/jleuko/qiad065. PubMed PMID:37224625 .
  4. Vähätupa, M, Nättinen, J, Aapola, U, Uusitalo-Järvinen, H, Uusitalo, H, Järvinen, TAH et al.. Proteomics Analysis of R-Ras Deficiency in Oxygen Induced Retinopathy. Int J Mol Sci. 2023;24 (9):. doi: 10.3390/ijms24097914. PubMed PMID:37175621 PubMed Central PMC10178533.
  5. Ojanen, MJT, Caro, FM, Aittomäki, S, Ploquin, MJ, Ortutay, Z, Pekkarinen, M et al.. FURIN regulates cytotoxic T-lymphocyte effector function and memory cell transition in mice. Eur J Immunol. 2023;53 (6):e2250246. doi: 10.1002/eji.202250246. PubMed PMID:37015057 .

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2022

  1. Valle, X, Mechó, S, Alentorn-Geli, E, Järvinen, TAH, Lempainen, L, Pruna, R et al.. Return to Play Prediction Accuracy of the MLG-R Classification System for Hamstring Injuries in Football Players: A Machine Learning Approach. Sports Med. 2022;52 (9):2271-2282. doi: 10.1007/s40279-022-01672-5. PubMed PMID:35610405 .
  2. Coentro, JQ, di Nubila, A, May, U, Prince, S, Zwaagstra, J, Järvinen, TAH et al.. Dual drug delivery collagen vehicles for modulation of skin fibrosis. Biomed Mater. 2022;17 (2):. doi: 10.1088/1748-605X/ac5673. PubMed PMID:35176732 .
  3. Salomaa, T, Pemmari, T, Määttä, J, Kummola, L, Salonen, N, González-Rodríguez, M et al.. IL-13Rα1 Suppresses Tumor Progression in Two-Stage Skin Carcinogenesis Model by Regulating Regulatory T Cells. J Invest Dermatol. 2022;142 (6):1565-1575.e17. doi: 10.1016/j.jid.2021.11.013. PubMed PMID:34808240 .

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2021

  1. Vähätupa, M, Salonen, N, Uusitalo-Järvinen, H, Järvinen, TAH. Selective Targeting and Tissue Penetration to the Retina by a Systemically Administered Vascular Homing Peptide in Oxygen Induced Retinopathy (OIR). Pharmaceutics. 2021;13 (11):. doi: 10.3390/pharmaceutics13111932. PubMed PMID:34834347 PubMed Central PMC8618640.
  2. Salomaa, T, Pemmari, T, Määttä, J, Kummola, L, Salonen, N, González-Rodríguez, M et al.. IL-13Rα1 Suppresses Tumor Progression in Two-Stage Skin Carcinogenesis Model by Regulating Regulatory T Cells. J Invest Dermatol. 2022;142 (6):1565-1575.e17. doi: 10.1016/j.jid.2021.11.013. PubMed PMID:34808240 .
  3. Coentro, JQ, May, U, Prince, S, Zwaagstra, J, Ritvos, O, Järvinen, TAH et al.. Adapting the Scar-in-a-Jar to Skin Fibrosis and Screening Traditional and Contemporary Anti-Fibrotic Therapies. Front Bioeng Biotechnol. 2021;9 :756399. doi: 10.3389/fbioe.2021.756399. PubMed PMID:34765594 PubMed Central PMC8576412.
  4. Iqbal, A, May, U, Prince, SN, Järvinen, TAH, Heydemann, A. Systemically Administered Homing Peptide Targets Dystrophic Lesions and Delivers Transforming Growth Factor-β (TGFβ) Inhibitor to Attenuate Murine Muscular Dystrophy Pathology. Pharmaceutics. 2021;13 (9):. doi: 10.3390/pharmaceutics13091506. PubMed PMID:34575582 PubMed Central PMC8471674.
  5. Contreras-Muñoz, P, Torrella, JR, Venegas, V, Serres, X, Vidal, L, Vila, I et al.. Muscle Precursor Cells Enhance Functional Muscle Recovery and Show Synergistic Effects With Postinjury Treadmill Exercise in a Muscle Injury Model in Rats. Am J Sports Med. 2021;49 (4):1073-1085. doi: 10.1177/0363546521989235. PubMed PMID:33719605 .
  6. De Rossi, G, Vähätupa, M, Cristante, E, Arokiasamy, S, Liyanage, SE, May, U et al.. Pathological Angiogenesis Requires Syndecan-4 for Efficient VEGFA-Induced VE-Cadherin Internalization. Arterioscler Thromb Vasc Biol. 2021;41 (4):1374-1389. doi: 10.1161/ATVBAHA.121.315941. PubMed PMID:33596666 PubMed Central PMC7613699.

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2020

  1. Pemmari, T, Laakso, J, Patrikainen, MS, Parkkila, S, Järvinen, TAH. Carbonic Anhydrase VI in Skin Wound Healing Study on Knockout Mice. Int J Mol Sci. 2020;21 (14):. doi: 10.3390/ijms21145092. PubMed PMID:32708518 PubMed Central PMC7404312.
  2. Vähätupa, M, Järvinen, TAH, Uusitalo-Järvinen, H. Exploration of Oxygen-Induced Retinopathy Model to Discover New Therapeutic Drug Targets in Retinopathies. Front Pharmacol. 2020;11 :873. doi: 10.3389/fphar.2020.00873. PubMed PMID:32595503 PubMed Central PMC7300227.
  3. Pemmari, T, Ivanova, L, May, U, Lingasamy, P, Tobi, A, Pasternack, A et al.. Exposed CendR Domain in Homing Peptide Yields Skin-Targeted Therapeutic in Epidermolysis Bullosa. Mol Ther. 2020;28 (8):1833-1845. doi: 10.1016/j.ymthe.2020.05.017. PubMed PMID:32497513 PubMed Central PMC7403337.
  4. Study Group of the Muscle and Tendon System from the Spanish Society of Sports Traumatology, Balius, R, Blasi, M, Pedret, C, Alomar, X, Peña-Amaro, J et al.. A Histoarchitectural Approach to Skeletal Muscle Injury: Searching for a Common Nomenclature. Orthop J Sports Med. 2020;8 (3):2325967120909090. doi: 10.1177/2325967120909090. PubMed PMID:32232071 PubMed Central PMC7092384.
  5. Hietanen, KE, Järvinen, TAH, Huhtala, H, Tolonen, TT, Kaartinen, IS. Histopathology and immunohistochemical analysis of 5-fluorouracil and triamcinolone treated keloids in double-blinded randomized controlled trial. Wound Repair Regen. 2020;28 (3):385-399. doi: 10.1111/wrr.12803. PubMed PMID:32112591 .
  6. Järvinen, TAH, Pemmari, T. Systemically Administered, Target-Specific, Multi-Functional Therapeutic Recombinant Proteins in Regenerative Medicine. Nanomaterials (Basel). 2020;10 (2):. doi: 10.3390/nano10020226. PubMed PMID:32013041 PubMed Central PMC7075297.

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2019

  1. Vähätupa, M, Pemmari, T, Junttila, I, Pesu, M, Järvinen, TAH. Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA). J Vis Exp. 2019; (154):. doi: 10.3791/60445. PubMed PMID:31904021 .
  2. Ketomäki, T, Vähätupa, M, May, U, Pemmari, T, Ruikka, E, Hietamo, J et al.. R-Ras regulates vascular permeability, but not overall healing in skin wounds. Exp Dermatol. 2019;28 (2):202-206. doi: 10.1111/exd.13851. PubMed PMID:30489650 .
  3. Järvinen, TAH, Ruoslahti, E. Generation of a multi-functional, target organ-specific, anti-fibrotic molecule by molecular engineering of the extracellular matrix protein, decorin. Br J Pharmacol. 2019;176 (1):16-25. doi: 10.1111/bph.14374. PubMed PMID:29847688 PubMed Central PMC6284330.

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2018

  1. Ketomäki, T, Vähätupa, M, May, U, Pemmari, T, Ruikka, E, Hietamo, J et al.. R-Ras regulates vascular permeability, but not overall healing in skin wounds. Exp Dermatol. 2019;28 (2):202-206. doi: 10.1111/exd.13851. PubMed PMID:30489650 .
  2. Vähätupa, M, Nättinen, J, Jylhä, A, Aapola, U, Kataja, M, Kööbi, P et al.. SWATH-MS Proteomic Analysis of Oxygen-Induced Retinopathy Reveals Novel Potential Therapeutic Targets. Invest Ophthalmol Vis Sci. 2018;59 (8):3294-3306. doi: 10.1167/iovs.18-23831. PubMed PMID:30025079 .
  3. Järvinen, TAH, Ruoslahti, E. Generation of a multi-functional, target organ-specific, anti-fibrotic molecule by molecular engineering of the extracellular matrix protein, decorin. Br J Pharmacol. 2019;176 (1):16-25. doi: 10.1111/bph.14374. PubMed PMID:29847688 PubMed Central PMC6284330.
  4. Schneider, M, Angele, P, Järvinen, TAH, Docheva, D. Rescue plan for Achilles: Therapeutics steering the fate and functions of stem cells in tendon wound healing. Adv Drug Deliv Rev. 2018;129 :352-375. doi: 10.1016/j.addr.2017.12.016. PubMed PMID:29278683 .
  5. Vähätupa, M, Cordova, ZM, Barker, H, Aittomäki, S, Uusitalo, H, Järvinen, TAH et al.. Furin deficiency in myeloid cells leads to attenuated revascularization in a mouse-model of oxygen-induced retinopathy. Exp Eye Res. 2018;166 :160-167. doi: 10.1016/j.exer.2017.10.013. PubMed PMID:29031855 .
  6. Sihvonen, R, Paavola, M, Malmivaara, A, Itälä, A, Joukainen, A, Nurmi, H et al.. Arthroscopic partial meniscectomy versus placebo surgery for a degenerative meniscus tear: a 2-year follow-up of the randomised controlled trial. Ann Rheum Dis. 2018;77 (2):188-195. doi: 10.1136/annrheumdis-2017-211172. PubMed PMID:28522452 PubMed Central PMC5867417.

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2017

  1. Schneider, M, Angele, P, Järvinen, TAH, Docheva, D. Rescue plan for Achilles: Therapeutics steering the fate and functions of stem cells in tendon wound healing. Adv Drug Deliv Rev. 2018;129 :352-375. doi: 10.1016/j.addr.2017.12.016. PubMed PMID:29278683 .
  2. Shen, Y, Russo, V, Zeglinski, MR, Sellers, SL, Wu, Z, Oram, C et al.. Recombinant Decorin Fusion Protein Attenuates Murine Abdominal Aortic Aneurysm Formation and Rupture. Sci Rep. 2017;7 (1):15857. doi: 10.1038/s41598-017-16194-8. PubMed PMID:29158532 PubMed Central PMC5696466.
  3. Vähätupa, M, Cordova, ZM, Barker, H, Aittomäki, S, Uusitalo, H, Järvinen, TAH et al.. Furin deficiency in myeloid cells leads to attenuated revascularization in a mouse-model of oxygen-induced retinopathy. Exp Eye Res. 2018;166 :160-167. doi: 10.1016/j.exer.2017.10.013. PubMed PMID:29031855 .
  4. Järvinen, TAH, Rashid, J, Valmari, T, May, U, Ahsan, F. Systemically Administered, Target-Specific Therapeutic Recombinant Proteins and Nanoparticles for Regenerative Medicine. ACS Biomater Sci Eng. 2017;3 (7):1273-1282. doi: 10.1021/acsbiomaterials.6b00746. PubMed PMID:33440515 .
  5. Sihvonen, R, Paavola, M, Malmivaara, A, Itälä, A, Joukainen, A, Nurmi, H et al.. Arthroscopic partial meniscectomy versus placebo surgery for a degenerative meniscus tear: a 2-year follow-up of the randomised controlled trial. Ann Rheum Dis. 2018;77 (2):188-195. doi: 10.1136/annrheumdis-2017-211172. PubMed PMID:28522452 PubMed Central PMC5867417.
  6. Kummola, L, Ortutay, Z, Vähätupa, M, Prince, S, Uusitalo-Järvinen, H, Järvinen, TAH et al.. R-Ras deficiency does not affect papain-induced IgE production in mice. Immun Inflamm Dis. 2017;5 (3):280-288. doi: 10.1002/iid3.168. PubMed PMID:28497586 PubMed Central PMC5569372.
  7. Contreras-Muñoz, P, Torrella, JR, Serres, X, Rizo-Roca, D, De la Varga, M, Viscor, G et al.. Postinjury Exercise and Platelet-Rich Plasma Therapies Improve Skeletal Muscle Healing in Rats But Are Not Synergistic When Combined. Am J Sports Med. 2017;45 (9):2131-2141. doi: 10.1177/0363546517702864. PubMed PMID:28453295 .

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