Publications

2021

  1. Nortunen, M, Parkkila, S, Saarnio, J, Huhta, H, Karttunen, TJ. Carbonic Anhydrases II and IX in Non-ampullary Duodenal Adenomas and Adenocarcinoma. J Histochem Cytochem. 2021; :221554211050133. doi: 10.1369/00221554211050133. PubMed PMID:34636283 .
  2. Gong, W, Aspatwar, A, Wang, S, Parkkila, S, Wu, X. COVID-19 pandemic: SARS-CoV-2 specific vaccines and challenges, protection via BCG trained immunity, and clinical trials. Expert Rev Vaccines. 2021;20 (7):857-880. doi: 10.1080/14760584.2021.1938550. PubMed PMID:34078215 PubMed Central PMC8220438.
  3. Urbanski, LJ, Vullo, D, Parkkila, S, Supuran, CT. An anion and small molecule inhibition study of the β-carbonic anhydrase from Staphylococcus aureus. J Enzyme Inhib Med Chem. 2021;36 (1):1088-1092. doi: 10.1080/14756366.2021.1931863. PubMed PMID:34056990 PubMed Central PMC8168783.
  4. Zolfaghari Emameh, R, Hosseini, SN, Parkkila, S. Application of beta and gamma carbonic anhydrase sequences as tools for identification of bacterial contamination in the whole genome sequence of inbred Wuzhishan minipig (Sus scrofa) annotated in databases. Database (Oxford). 2021;2021 :. doi: 10.1093/database/baab029. PubMed PMID:34003248 PubMed Central PMC8130508.
  5. Aspatwar, A, Gong, W, Wang, S, Wu, X, Parkkila, S. Tuberculosis vaccine BCG: the magical effect of the old vaccine in the fight against the COVID-19 pandemic. Int Rev Immunol. 2021; :1-14. doi: 10.1080/08830185.2021.1922685. PubMed PMID:33960271 PubMed Central PMC8108189.
  6. Nortunen, M, Väkiparta, N, Parkkila, S, Saarnio, J, Huhta, H, Karttunen, TJ et al.. Carbonic Anhydrases II, IX, and XII in Reflux Esophagitis. Dig Dis Sci. 2021; :. doi: 10.1007/s10620-021-06985-5. PubMed PMID:33939141 .
  7. Angeli, A, Urbański, LJ, Hytönen, VP, Parkkila, S, Supuran, CT. Activation of the β-carbonic anhydrase from the protozoan pathogen Trichomonas vaginalis with amines and amino acids. J Enzyme Inhib Med Chem. 2021;36 (1):758-763. doi: 10.1080/14756366.2021.1897802. PubMed PMID:33715570 PubMed Central PMC7952076.
  8. Maleta, K, Fan, YM, Luoma, J, Ashorn, U, Bendabenda, J, Dewey, KG et al.. Infections and systemic inflammation are associated with lower plasma concentration of insulin-like growth factor I among Malawian children. Am J Clin Nutr. 2021;113 (2):380-390. doi: 10.1093/ajcn/nqaa327. PubMed PMID:33381802 PubMed Central PMC7851819.
  9. Urbański, LJ, Angeli, A, Hytönen, VP, Di Fiore, A, De Simone, G, Parkkila, S et al.. Inhibition of the β-carbonic anhydrase from the protozoan pathogen Trichomonas vaginalis with sulphonamides. J Enzyme Inhib Med Chem. 2021;36 (1):329-334. doi: 10.1080/14756366.2020.1863958. PubMed PMID:33356653 PubMed Central PMC7782162.
  10. Liu, Z, Fan, YM, Ashorn, P, Cheung, YB, Hallamaa, L, Hyöty, H et al.. Faecal regenerating 1B protein concentration is not associated with child growth in rural Malawi. J Paediatr Child Health. 2021;57 (3):388-394. doi: 10.1111/jpc.15231. PubMed PMID:33112481 PubMed Central PMC8048694.
Search PubMed

2020

  1. Zolfaghari Emameh, R, Masoori, L, Nosrati, H, Falak, R, Parkkila, S. Identification and characterization of the first fish parvalbumin-like protein data from a pathogenic fungal species, Trichophyton violaceum. Data Brief. 2020;33 :106420. doi: 10.1016/j.dib.2020.106420. PubMed PMID:33134447 PubMed Central PMC7586069.
  2. Barker, H, Parkkila, S. Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2. PLoS One. 2020;15 (10):e0240647. doi: 10.1371/journal.pone.0240647. PubMed PMID:33112891 PubMed Central PMC7592753.
  3. Liu, Z, Fan, YM, Ashorn, P, Cheung, YB, Hallamaa, L, Hyöty, H et al.. Faecal regenerating 1B protein concentration is not associated with child growth in rural Malawi. J Paediatr Child Health. 2021;57 (3):388-394. doi: 10.1111/jpc.15231. PubMed PMID:33112481 PubMed Central PMC8048694.
  4. Urbański, LJ, Angeli, A, Hytönen, VP, Di Fiore, A, Parkkila, S, De Simone, G et al.. Inhibition of the newly discovered β‑carbonic anhydrase from the protozoan pathogen Trichomonas vaginalis with inorganic anions and small molecules. J Inorg Biochem. 2020;213 :111274. doi: 10.1016/j.jinorgbio.2020.111274. PubMed PMID:33068968 .
  5. Urbanski, LJ, Bua, S, Angeli, A, Kuuslahti, M, Hytönen, VP, Supuran, CT et al.. Sulphonamide inhibition profile of Staphylococcus aureus β-carbonic anhydrase. J Enzyme Inhib Med Chem. 2020;35 (1):1834-1839. doi: 10.1080/14756366.2020.1826942. PubMed PMID:32972256 PubMed Central PMC7534311.
  6. Aspatwar, A, Berrino, E, Bua, S, Carta, F, Capasso, C, Parkkila, S et al.. Toxicity evaluation of sulfamides and coumarins that efficiently inhibit human carbonic anhydrases. J Enzyme Inhib Med Chem. 2020;35 (1):1765-1772. doi: 10.1080/14756366.2020.1822829. PubMed PMID:32942905 PubMed Central PMC7534274.
  7. Pemmari, T, Laakso, J, Patrikainen, MS, Parkkila, S, Järvinen, TAH. Carbonic Anhydrase VI in Skin Wound Healing Study on Car6 Knockout Mice. Int J Mol Sci. 2020;21 (14):. doi: 10.3390/ijms21145092. PubMed PMID:32708518 PubMed Central PMC7404312.
  8. Haapasalo, J, Nordfors, K, Haapasalo, H, Parkkila, S. The Expression of Carbonic Anhydrases II, IX and XII in Brain Tumors. Cancers (Basel). 2020;12 (7):. doi: 10.3390/cancers12071723. PubMed PMID:32610540 PubMed Central PMC7408524.
  9. Urbański, LJ, Di Fiore, A, Azizi, L, Hytönen, VP, Kuuslahti, M, Buonanno, M et al.. Biochemical and structural characterisation of a protozoan beta-carbonic anhydrase from Trichomonas vaginalis. J Enzyme Inhib Med Chem. 2020;35 (1):1292-1299. doi: 10.1080/14756366.2020.1774572. PubMed PMID:32515610 PubMed Central PMC7717681.
  10. Anduran, E, Aspatwar, A, Parvathaneni, NK, Suylen, D, Bua, S, Nocentini, A et al.. Hypoxia-Activated Prodrug Derivatives of Carbonic Anhydrase Inhibitors in Benzenesulfonamide Series: Synthesis and Biological Evaluation. Molecules. 2020;25 (10):. doi: 10.3390/molecules25102347. PubMed PMID:32443462 PubMed Central PMC7287649.
  11. Zolfaghari Emameh, R, Kuuslahti, M, Nosrati, H, Lohi, H, Parkkila, S. Assessment of databases to determine the validity of β- and γ-carbonic anhydrase sequences from vertebrates. BMC Genomics. 2020;21 (1):352. doi: 10.1186/s12864-020-6762-2. PubMed PMID:32393172 PubMed Central PMC7216627.
  12. Angeli, A, Etxebeste-Mitxeltorena, M, Sanmartín, C, Espuelas, S, Moreno, E, Azqueta, A et al.. Tellurides Bearing Sulfonamides as Novel Inhibitors of Leishmanial Carbonic Anhydrase with Potent Antileishmanial Activity. J Med Chem. 2020;63 (8):4306-4314. doi: 10.1021/acs.jmedchem.0c00211. PubMed PMID:32223141 .
  13. Aspatwar, A, Parvathaneni, NK, Barker, H, Anduran, E, Supuran, CT, Dubois, L et al.. Design, synthesis, in vitro inhibition and toxicological evaluation of human carbonic anhydrases I, II and IX inhibitors in 5-nitroimidazole series. J Enzyme Inhib Med Chem. 2020;35 (1):109-117. doi: 10.1080/14756366.2019.1685510. PubMed PMID:31687859 PubMed Central PMC6844379.
  14. Aspatwar, A, Hammaren, M, Parikka, M, Parkkila, S, Carta, F, Bozdag, M et al.. In vitro inhibition of Mycobacterium tuberculosis β-carbonic anhydrase 3 with Mono- and dithiocarbamates and evaluation of their toxicity using zebrafish developing embryos. J Enzyme Inhib Med Chem. 2020;35 (1):65-71. doi: 10.1080/14756366.2019.1683007. PubMed PMID:31663386 PubMed Central PMC6830242.
  15. Llanos, MA, Sbaraglini, ML, Villalba, ML, Ruiz, MD, Carrillo, C, Alba Soto, C et al.. A structure-based approach towards the identification of novel antichagasic compounds: Trypanosoma cruzi carbonic anhydrase inhibitors. J Enzyme Inhib Med Chem. 2020;35 (1):21-30. doi: 10.1080/14756366.2019.1677638. PubMed PMID:31619095 PubMed Central PMC6807911.
Search PubMed

2019

Al-Tamimi AS, Etxebeste-Mitxeltorena M, Sanmartín C, Jiménez-Ruiz A, Syrjänen L, Parkkila S, Selleri S, Carta F, Angeli A, Supuran CT
Discovery of new organoselenium compounds as antileishmanial agents.
Bioorg Chem ;2019
PMID

Bua S, Haapanen S, Kuuslahti M, Parkkila S, Supuran CT
Entamoeba histolytica with Amino Acids and Amines.
Metabolites ;2019
PMID

Ketomäki T, Vähätupa M, May U, Pemmari T, Ruikka E, Hietamo J, Kaipiainen P, Barker H, Parkkila S, Uusitalo-Järvinen H, Järvinen TAH
R-Ras regulates vascular permeability, but not overall healing in skin wounds.
Exp Dermatol ;28(2)202-206, 2019
PMID

2018

Vullo D, Syrjänen L, Kuuslahti M, Parkkila S, Supuran CT
Anion inhibition studies of a beta carbonic anhydrase from the malaria mosquito Anopheles gambiae.
J Enzyme Inhib Med Chem ;33(1)359-363, 2018
PMID

Aspatwar A, Winum JY, Carta F, Supuran CT, Hammaren M, Parikka M, Parkkila S
In Vivo Studies.
Molecules ;2018
PMID

Nortunen M, Huhta H, Helminen O, Parkkila S, Kauppila JH, Karttunen TJ, Saarnio J
Carbonic anhydrases II, IX, and XII in Barrett’s esophagus and adenocarcinoma.
Virchows Arch ;473(5)567-575, 2018
PMID

Angeli A, Kuuslahti M, Parkkila S, Supuran CT
Activation studies with amines and amino acids of the a-carbonic anhydrase from the pathogenic protozoan Trypanosoma cruzi.
Bioorg Med Chem ;26(14)4187-4190, 2018
PMID

Leppänen J, Helminen O, Huhta H, Kauppila JH, Isohookana J, Haapasaari KM, Parkkila S, Saarnio J, Lehenkari PP, Karttunen TJ
Weak HIF-1alpha expression indicates poor prognosis in resectable pancreatic ductal adenocarcinoma.
World J Surg Oncol ;16(1)127, 2018
PMID

Bua S, Haapanen S, Kuuslahti M, Parkkila S, Supuran CT
Entamoeba histolytica.
Int J Mol Sci ;2018
PMID

Aspatwar A, Becker HM, Parvathaneni NK, Hammaren M, Svorjova A, Barker H, Supuran CT, Dubois L, Lambin P, Parikka M, Parkkila S, Winum JY
Nitroimidazole-based inhibitors DTP338 and DTP348 are safe for zebrafish embryos and efficiently inhibit the activity of human CA IX in Xenopus oocytes.
J Enzyme Inhib Med Chem ;33(1)1064-1073, 2018
PMID

Haapanen S, Bua S, Kuuslahti M, Parkkila S, Supuran CT
Entamoeba histolytica.
Molecules ;2018
PMID

Leppänen J, Helminen O, Huhta H, Kauppila JH, Isohookana J, Haapasaari KM, Karihtala P, Parkkila S, Saarnio J, Lehenkari PP, Karttunen TJ
Toll-like receptors 2, 4 and 9 and hypoxia markers HIF-1alpha and CAIX in pancreatic intraepithelial neoplasia.
APMIS ;126(11)852-863, 2018
PMID

Angeli A, Donald WA, Parkkila S, Supuran CT
Activation studies with amines and amino acids of the ß-carbonic anhydrase from the pathogenic protozoan Leishmania donovani chagasi.
Bioorg Chem ;2018
PMID

Zolfaghari Emameh R, Barker HR, Hytönen VP, Parkkila S
Involvement of ß-Carbonic Anhydrase Genes in Bacterial Genomic Islands and Their Horizontal Transfer to Protists.
Appl Environ Microbiol ;2018
PMID

Zolfaghari Emameh R, Purmonen S, Sukura A, Parkkila S
Surveillance and diagnosis of zoonotic foodborne parasites.
Food Sci Nutr ;6(1)3-17, 2018
PMID

Karjalainen SL, Haapasalo HK, Aspatwar A, Barker H, Parkkila S, Haapasalo JA
Carbonic anhydrase related protein expression in astrocytomas and oligodendroglial tumors.
BMC Cancer ;18(1)584, 2018
PMID

Aspatwar A, Haapanen S, Parkkila S
An Update on the Metabolic Roles of Carbonic Anhydrases in the Model Alga Chlamydomonas reinhardtii.
Metabolites ;2018
PMID

2017

Patrikainen MS, Tolvanen MEE, Aspatwar A, Barker HR, Ortutay C, Jänis J, Laitaoja M, Hytönen VP, Azizi L, Manandhar P, Jáger E, Vullo D, Kukkurainen S, Hilvo M, Supuran CT, Parkkila S
Danio rerio) pentraxin-carbonic anhydrase.
PeerJ ;2017
PMID

Kazokaite J, Aspatwar A, Parkkila S, Matulis D
An update on anticancer drug development and delivery targeting carbonic anhydrase IX.
PeerJ ;2017
PMID

Kazokaite J, Aspatwar A, Kairys V, Parkkila S, Matulis D
Fluorinated benzenesulfonamide anticancer inhibitors of carbonic anhydrase IX exhibit lower toxic effects on zebrafish embryonic development than ethoxzolamide.
Drug Chem Toxicol ;40(3)309-319, 2017
PMID

Aspatwar A, Hammarén M, Koskinen S, Luukinen B, Barker H, Carta F, Supuran CT, Parikka M, Parkkila S
ß-CA-specific inhibitor dithiocarbamate Fc14-584B: a novel antimycobacterial agent with potential to treat drug-resistant tuberculosis.
J Enzyme Inhib Med Chem ;32(1)832-840, 2017
PMID

Barker H, Aaltonen M, Pan P, Vähätupa M, Kaipiainen P, May U, Prince S, Uusitalo-Järvinen H, Waheed A, Pastoreková S, Sly WS, Parkkila S, Järvinen TA
Role of carbonic anhydrases in skin wound healing.
Exp Mol Med ;49(5)e334, 2017
PMID

Järvinen P, Kivelä AJ, Nummela P, Lepistö A, Ristimäki A, Parkkila S
Carbonic anhydrase II: a novel biomarker for pseudomyxoma peritonei.
APMIS ;125(3)207-212, 2017
PMID

2016

Viikilä P, Kivelä AJ, Mustonen H, Koskensalo S, Waheed A, Sly WS, Pastorek J, Pastorekova S, Parkkila S, Haglund C
Carbonic anhydrase enzymes II, VII, IX and XII in colorectal carcinomas.
World J Gastroenterol ;22(36)8168-77, 2016
PMID

Patrikainen MS, Pan P, Barker HR, Parkkila S
Altered gene expression in the lower respiratory tract of Car6 (-/-) mice.
Transgenic Res ;25(5)649-64, 2016
PMID

Zolfaghari Emameh R, Kuuslahti M, Näreaho A, Sukura A, Parkkila S
Innovative molecular diagnosis of Trichinella species based on ß-carbonic anhydrase genomic sequence.
Microb Biotechnol ;9(2)172-9, 2016
PMID

Niinimaki E, Muola P, Parkkila S, Kholová I, Haapasalo H, Pastorekova S, Pastorek J, Paavonen T, Mennander A
Carbonic anhydrase IX deposits are associated with increased ascending aortic dilatation.
Scand Cardiovasc J ;50(3)162-6, 2016
PMID

Zolfaghari Emameh R, Barker HR, Tolvanen ME, Parkkila S, Hytönen VP
Horizontal transfer of ß-carbonic anhydrase genes from prokaryotes to protozoans, insects, and nematodes.
Parasit Vectors ;2016
PMID

Zolfaghari Emameh R, Barker HR, Syrjänen L, Urbanski L, Supuran CT, Parkkila S
Identification and inhibition of carbonic anhydrases from nematodes.
J Enzyme Inhib Med Chem ;31(sup4)176-184, 2016
PMID