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Anestesiologia, Tehohoito ja Ensihoitolääketiede

Anesthesiology, Intensive Care and Emergency Medicine

Julkaisut

ORCID (Johanna Hästbacka)

2024 

  1. Turunen, A, Kuuliala, K, Kuuliala, A, Puolakkainen, P, Kylänpää, L, Hästbacka, J et al.. Syndecan-1 Levels and Early Positive Fluid Balance Are Associated with Disease Severity in Acute Pancreatitis. Pancreas. 2024; :. doi: 10.1097/MPA.0000000000002366. PubMed PMID:38696459 .
  2. Nissilä, E, Hynninen, M, Jalkanen, V, Kuitunen, A, Bäcklund, M, Inkinen, O et al.. The effectiveness of a brief intervention for intensive care unit patients with hazardous alcohol use: a randomized controlled trial. Crit Care. 2024;28 (1):145. doi: 10.1186/s13054-024-04925-z. PubMed PMID:38689346 .
  3. Ceric, A, Holgersson, J, May, TL, Skrifvars, MB, Hästbacka, J, Saxena, M et al.. Effect of level of sedation on outcomes in critically ill adult patients: a systematic review of clinical trials with meta-analysis and trial sequential analysis. EClinicalMedicine. 2024;71 :102569. doi: 10.1016/j.eclinm.2024.102569. PubMed PMID:38572080 PubMed Central PMC10990717.
  4. Ollila, H, Pihlajamaa, J, Martola, J, Hokkanen, L, Tiainen, M, Hästbacka, J et al.. Authors’ response: ”Brain magnetic resonance imaging findings six months after critical COVID-19: A prospective cohort study”. J Crit Care. 2024; :154800. doi: 10.1016/j.jcrc.2024.154800. PubMed PMID:38555251 .
  5. Pietiläinen, L, Hästbacka, J, Bendel, S, Bäcklund, M, Reinikainen, M. Physicians’ perceptions of intensive care patients’ 1-year prognoses compared to realistic prognoses. Acta Anaesthesiol Scand. 2024;68 (5):655-663. doi: 10.1111/aas.14400. PubMed PMID:38438302 .
  6. Holm, A, Reinikainen, M, Kurola, J, Vaahersalo, J, Tiainen, M, Varpula, T et al.. Factors associated with fever after cardiac arrest: A post-hoc analysis of the FINNRESUSCI study. Acta Anaesthesiol Scand. 2024;68 (5):635-644. doi: 10.1111/aas.14387. PubMed PMID:38351520 .
  7. Feola, S, Chiaro, J, Fusciello, M, Russo, S, Kleino, I, Ylösmäki, L et al.. PeptiVAX: A new adaptable peptides-delivery platform for development of CTL-based, SARS-CoV-2 vaccines. Int J Biol Macromol. 2024;262 (Pt 1):129926. doi: 10.1016/j.ijbiomac.2024.129926. PubMed PMID:38331062 .
  8. Mortensen, CB, Andersen-Ranberg, NC, Poulsen, LM, Granholm, A, Rasmussen, BS, Kjær, MN et al.. Long-term outcomes with haloperidol versus placebo in acutely admitted adult ICU patients with delirium. Intensive Care Med. 2024;50 (1):103-113. doi: 10.1007/s00134-023-07282-7. PubMed PMID:38170227 PubMed Central PMC10811094.
  9. Ollila, H, Pihlajamaa, J, Martola, J, Kuusela, L, Blennow, K, Zetterberg, H et al.. Brain magnetic resonance imaging findings six months after critical COVID-19: A prospective cohort study. J Crit Care. 2024;80 :154502. doi: 10.1016/j.jcrc.2023.154502. PubMed PMID:38113746 .
  10. Anthon, CT, Pène, F, Perner, A, Azoulay, E, Puxty, K, Van De Louw, A et al.. Correction: Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT-ICU). Intensive Care Med. 2024;50 (1):154-155. doi: 10.1007/s00134-023-07291-6. PubMed PMID:38078947 PubMed Central PMC10810924.
  11. Nissilä, E, Suojaranta, R, Hynninen, M, Dahlbacka, S, Hästbacka, J. Hazardous alcohol consumption and perioperative complications in a cardiac surgery patient. A retrospective study. Acta Anaesthesiol Scand. 2024;68 (3):337-344. doi: 10.1111/aas.14361. PubMed PMID:38014920 .
  12. Pietiläinen, L, Hästbacka, J, Bäcklund, M, Selander, T, Reinikainen, M. A novel score for predicting 1-year mortality of intensive care patients. Acta Anaesthesiol Scand. 2024;68 (2):195-205. doi: 10.1111/aas.14336. PubMed PMID:37771172 .

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2023 

  1. Ollila, H, Pihlajamaa, J, Martola, J, Kuusela, L, Blennow, K, Zetterberg, H et al.. Brain magnetic resonance imaging findings six months after critical COVID-19: A prospective cohort study. J Crit Care. 2024;80 :154502. doi: 10.1016/j.jcrc.2023.154502. PubMed PMID:38113746 .
  2. Nissilä, E, Suojaranta, R, Hynninen, M, Dahlbacka, S, Hästbacka, J. Hazardous alcohol consumption and perioperative complications in a cardiac surgery patient. A retrospective study. Acta Anaesthesiol Scand. 2024;68 (3):337-344. doi: 10.1111/aas.14361. PubMed PMID:38014920 .
  3. Laurikkala, J, Ameloot, K, Reinikainen, M, Palmers, PJ, De Deyne, C, Bert, F et al.. The effect of higher or lower mean arterial pressure on kidney function after cardiac arrest: a post hoc analysis of the COMACARE and NEUROPROTECT trials. Ann Intensive Care. 2023;13 (1):113. doi: 10.1186/s13613-023-01210-0. PubMed PMID:37987871 PubMed Central PMC10663425.
  4. Halvorsen, P, Hultström, M, Hästbacka, J, Larsson, IM, Eklund, R, Arnberg, FK et al.. Health-related quality of life after surviving intensive care for COVID-19: a prospective multicenter cohort study. Sci Rep. 2023;13 (1):18035. doi: 10.1038/s41598-023-45346-2. PubMed PMID:37865685 PubMed Central PMC10590404.
  5. Anthon, CT, Pène, F, Perner, A, Azoulay, E, Puxty, K, Van De Louw, A et al.. Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT-ICU). Intensive Care Med. 2023;49 (11):1327-1338. doi: 10.1007/s00134-023-07225-2. PubMed PMID:37812225 PubMed Central PMC10622358.
  6. Hästbacka, J, But, A, Strandberg, G, Lipcsey, M. Risk of malignant disease in 1-year sepsis survivors, a registry-based nationwide follow-up study. Crit Care. 2023;27 (1):376. doi: 10.1186/s13054-023-04654-9. PubMed PMID:37773171 PubMed Central PMC10543324.
  7. Pietiläinen, L, Hästbacka, J, Bäcklund, M, Selander, T, Reinikainen, M. A novel score for predicting 1-year mortality of intensive care patients. Acta Anaesthesiol Scand. 2024;68 (2):195-205. doi: 10.1111/aas.14336. PubMed PMID:37771172 .
  8. Aslam, TN, Klitgaard, TL, Ahlstedt, CAO, Andersen, FH, Chew, MS, Collet, MO et al.. A survey of preferences for respiratory support in the intensive care unit for patients with acute hypoxaemic respiratory failure. Acta Anaesthesiol Scand. 2023;67 (10):1383-1394. doi: 10.1111/aas.14317. PubMed PMID:37737652 .
  9. Niemelä, V, Siddiqui, F, Ameloot, K, Reinikainen, M, Grand, J, Hästbacka, J et al.. Higher versus lower blood pressure targets after cardiac arrest: Systematic review with individual patient data meta-analysis. Resuscitation. 2023;189 :109862. doi: 10.1016/j.resuscitation.2023.109862. PubMed PMID:37295549 .
  10. Wetterslev, M, Hylander Møller, M, Granholm, A, Hassager, C, Haase, N, Lange, T et al.. Atrial Fibrillation (AFIB) in the ICU: Incidence, Risk Factors, and Outcomes: The International AFIB-ICU Cohort Study. Crit Care Med. 2023;51 (9):1124-1137. doi: 10.1097/CCM.0000000000005883. PubMed PMID:37078722 .
  11. Andersen-Ranberg, NC, Poulsen, LM, Perner, A, Hästbacka, J, Morgan, M, Citerio, G et al.. Haloperidol vs. placebo for the treatment of delirium in ICU patients: a pre-planned, secondary Bayesian analysis of the AID-ICU trial. Intensive Care Med. 2023;49 (4):411-420. doi: 10.1007/s00134-023-07024-9. PubMed PMID:36971791 .
  12. Yar, A, Uusitalo, V, Vaara, SM, Holmström, M, Vuorinen, AM, Heliö, T et al.. Cardiac magnetic resonance -detected myocardial injury is not associated with long-term symptoms in patients hospitalized due to COVID-19. PLoS One. 2023;18 (3):e0282394. doi: 10.1371/journal.pone.0282394. PubMed PMID:36888600 PubMed Central PMC9994679.
  13. Pihlaja, RE, Kauhanen, LS, Ollila, HS, Tuulio-Henriksson, AS, Koskinen, SK, Tiainen, M et al.. Associations of subjective and objective cognitive functioning after COVID-19: A six-month follow-up of ICU, ward, and home-isolated patients. Brain Behav Immun Health. 2023;27 :100587. doi: 10.1016/j.bbih.2023.100587. PubMed PMID:36624888 PubMed Central PMC9812472.

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2022 

  1. Ceric, A, Holgersson, J, May, T, Skrifvars, MB, Hästbacka, J, Saxena, M et al.. Level of sedation in critically ill adult patients: a protocol for a systematic review with meta-analysis and trial sequential analysis. BMJ Open. 2022;12 (9):e061806. doi: 10.1136/bmjopen-2022-061806. PubMed PMID:36691212 PubMed Central PMC9462111.
  2. Inkinen, N, Pettilä, V, Valkonen, M, Serlo, M, Bäcklund, M, Hästbacka, J et al.. Non-interventional follow-up versus fluid bolus in RESPONSE to oliguria in hemodynamically stable critically ill patients: a randomized controlled pilot trial. Crit Care. 2022;26 (1):401. doi: 10.1186/s13054-022-04283-8. PubMed PMID:36550559 PubMed Central PMC9773608.
  3. Andersen-Ranberg, NC, Poulsen, LM, Perner, A, Wetterslev, J, Estrup, S, Hästbacka, J et al.. Haloperidol for the Treatment of Delirium in ICU Patients. N Engl J Med. 2022;387 (26):2425-2435. doi: 10.1056/NEJMoa2211868. PubMed PMID:36286254 .
  4. Anthon, CT, Pène, F, Perner, A, Azoulay, E, Puxty, K, Van De Louw, A et al.. Platelet transfusions and thrombocytopenia in intensive care units: Protocol for an international inception cohort study (PLOT-ICU). Acta Anaesthesiol Scand. 2022;66 (9):1146-1155. doi: 10.1111/aas.14124. PubMed PMID:36054145 PubMed Central PMC9542787.
  5. Ollila, H, Pihlaja, R, Koskinen, S, Tuulio-Henriksson, A, Salmela, V, Tiainen, M et al.. Long-term cognitive functioning is impaired in ICU-treated COVID-19 patients: a comprehensive controlled neuropsychological study. Crit Care. 2022;26 (1):223. doi: 10.1186/s13054-022-04092-z. PubMed PMID:35858899 PubMed Central PMC9297673.
  6. Kattainen, S, Lindahl, A, Vasankari, T, Ollila, H, Volmonen, K, Piirilä, P et al.. Lung function and exercise capacity 6 months after hospital discharge for critical COVID-19. BMC Pulm Med. 2022;22 (1):243. doi: 10.1186/s12890-022-02023-w. PubMed PMID:35733179 PubMed Central PMC9215155.
  7. Póvoa, P, Martin-Loeches, I, Duska, F, CoBaTrICe Collaboration. Updated competency-based training in intensive care: next step towards a healthcare union in Europe?. Intensive Care Med. 2022;48 (8):1093-1094. doi: 10.1007/s00134-022-06783-1. PubMed PMID:35715645 .
  8. Skrifvars, MB, Ameloot, K, Grand, J, Reinikainen, M, Hästbacka, J, Niemelä, V et al.. Protocol for an individual patient data meta-analysis on blood pressure targets after cardiac arrest. Acta Anaesthesiol Scand. 2022;66 (7):890-897. doi: 10.1111/aas.14090. PubMed PMID:35616252 PubMed Central PMC9543739.
  9. Andersen-Ranberg, N, Poulsen, LM, Perner, A, Hästbacka, J, Morgan, MPG, Citerio, G et al.. Agents intervening against delirium in the intensive care unit trial-Protocol for a secondary Bayesian analysis. Acta Anaesthesiol Scand. 2022;66 (7):898-903. doi: 10.1111/aas.14091. PubMed PMID:35580239 PubMed Central PMC9540259.
  10. Pietiläinen, L, Bäcklund, M, Hästbacka, J, Reinikainen, M. Premorbid functional status as an outcome predictor in intensive care patients aged over 85 years. BMC Geriatr. 2022;22 (1):38. doi: 10.1186/s12877-021-02746-1. PubMed PMID:35012458 PubMed Central PMC8751370.
  11. Holmberg, V, Salmi, H, Kattainen, S, Ollgren, J, Kantele, A, Pynnönen, J et al.. Association between first language and SARS-CoV-2 infection rates, hospitalization, intensive care admissions and death in Finland: a population-based observational cohort study. Clin Microbiol Infect. 2022;28 (1):107-113. doi: 10.1016/j.cmi.2021.08.022. PubMed PMID:34949510 PubMed Central PMC8482016.
  12. Wetterslev, M, Møller, MH, Granholm, A, Hassager, C, Haase, N, Aslam, TN et al.. Management of acute atrial fibrillation in the intensive care unit: An international survey. Acta Anaesthesiol Scand. 2022;66 (3):375-385. doi: 10.1111/aas.14007. PubMed PMID:34870855 .
  13. Humaloja, J, Lähde, M, Ashton, NJ, Reinikainen, M, Hästbacka, J, Jakkula, P et al.. GFAp and tau protein as predictors of neurological outcome after out-of-hospital cardiac arrest: A post hoc analysis of the COMACARE trial. Resuscitation. 2022;170 :141-149. doi: 10.1016/j.resuscitation.2021.11.033. PubMed PMID:34863908 PubMed Central PMC8786666.
  14. Chew, MS, Kattainen, S, Haase, N, Buanes, EA, Kristinsdottir, LB, Hofsø, K et al.. A descriptive study of the surge response and outcomes of ICU patients with COVID-19 during first wave in Nordic countries. Acta Anaesthesiol Scand. 2022;66 (1):56-64. doi: 10.1111/aas.13983. PubMed PMID:34570897 PubMed Central PMC8652908.
  15. Salmi, H, Heinonen, S, Hästbacka, J, Lääperi, M, Rautiainen, P, Miettinen, PJ et al.. New-onset type 1 diabetes in Finnish children during the COVID-19 pandemic. Arch Dis Child. 2022;107 (2):180-185. doi: 10.1136/archdischild-2020-321220. PubMed PMID:34045208 .

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2021 

  1. Holmberg, V, Salmi, H, Kattainen, S, Ollgren, J, Kantele, A, Pynnönen, J et al.. Association between first language and SARS-CoV-2 infection rates, hospitalization, intensive care admissions and death in Finland: a population-based observational cohort study. Clin Microbiol Infect. 2022;28 (1):107-113. doi: 10.1016/j.cmi.2021.08.022. PubMed PMID:34949510 PubMed Central PMC8482016.
  2. Kurki, SN, Kantonen, J, Kaivola, K, Hokkanen, L, Mäyränpää, MI, Puttonen, H et al.. APOE ε4 associates with increased risk of severe COVID-19, cerebral microhaemorrhages and post-COVID mental fatigue: a Finnish biobank, autopsy and clinical study. Acta Neuropathol Commun. 2021;9 (1):199. doi: 10.1186/s40478-021-01302-7. PubMed PMID:34949230 PubMed Central PMC8696243.
  3. Wetterslev, M, Møller, MH, Granholm, A, Hassager, C, Haase, N, Aslam, TN et al.. Management of acute atrial fibrillation in the intensive care unit: An international survey. Acta Anaesthesiol Scand. 2022;66 (3):375-385. doi: 10.1111/aas.14007. PubMed PMID:34870855 .
  4. Humaloja, J, Lähde, M, Ashton, NJ, Reinikainen, M, Hästbacka, J, Jakkula, P et al.. GFAp and tau protein as predictors of neurological outcome after out-of-hospital cardiac arrest: A post hoc analysis of the COMACARE trial. Resuscitation. 2022;170 :141-149. doi: 10.1016/j.resuscitation.2021.11.033. PubMed PMID:34863908 PubMed Central PMC8786666.
  5. Laurikkala, J, Aneman, A, Peng, A, Reinikainen, M, Pham, P, Jakkula, P et al.. Association of deranged cerebrovascular reactivity with brain injury following cardiac arrest: a post-hoc analysis of the COMACARE trial. Crit Care. 2021;25 (1):350. doi: 10.1186/s13054-021-03764-6. PubMed PMID:34583763 PubMed Central PMC8477475.
  6. Humaloja, J, Vento, M, Kuligowski, J, Andersson, S, Piñeiro-Ramos, JD, Sánchez-Illana, Á et al.. High Oxygen Does Not Increase Reperfusion Injury Assessed with Lipid Peroxidation Biomarkers after Cardiac Arrest: A Post Hoc Analysis of the COMACARE Trial. J Clin Med. 2021;10 (18):. doi: 10.3390/jcm10184226. PubMed PMID:34575337 PubMed Central PMC8471647.
  7. Chew, MS, Kattainen, S, Haase, N, Buanes, EA, Kristinsdottir, LB, Hofsø, K et al.. A descriptive study of the surge response and outcomes of ICU patients with COVID-19 during first wave in Nordic countries. Acta Anaesthesiol Scand. 2022;66 (1):56-64. doi: 10.1111/aas.13983. PubMed PMID:34570897 PubMed Central PMC8652908.
  8. Holm, A, Kirkegaard, H, Taccone, FS, Søreide, E, Grejs, AM, Toome, V et al.. Factors Associated With Rebound Hyperthermia After Targeted Temperature Management in Out-of-Hospital Cardiac Arrest Patients: An Explorative Substudy of the Time-Differentiated Therapeutic Hypothermia in Out-of-Hospital Cardiac Arrest Survivors Trial. Crit Care Explor. 2021;3 (7):e0458. doi: 10.1097/CCE.0000000000000458. PubMed PMID:34250498 PubMed Central PMC8263323.
  9. Broberg, M, Hästbacka, J, Helle, E. From Stem Cells to Populations-Using hiPSC, Next-Generation Sequencing, and GWAS to Explore the Genetic and Molecular Mechanisms of Congenital Heart Defects. Genes (Basel). 2021;12 (6):. doi: 10.3390/genes12060921. PubMed PMID:34208537 PubMed Central PMC8235101.
  10. Kortelainen, J, Ala-Kokko, T, Tiainen, M, Strbian, D, Rantanen, K, Laurila, J et al.. Early recovery of frontal EEG slow wave activity during propofol sedation predicts outcome after cardiac arrest. Resuscitation. 2021;165 :170-176. doi: 10.1016/j.resuscitation.2021.05.032. PubMed PMID:34111496 .
  11. Forsblom, E, Silén, S, Kortela, E, Ahava, M, Kreivi, HR, Holmberg, V et al.. Male predominance in disease severity and mortality in a low Covid-19 epidemic and low case-fatality area – a population-based registry study. Infect Dis (Lond). 2021;53 (10):789-799. doi: 10.1080/23744235.2021.1936157. PubMed PMID:34100692 .
  12. Salmi, H, Heinonen, S, Hästbacka, J, Lääperi, M, Rautiainen, P, Miettinen, PJ et al.. New-onset type 1 diabetes in Finnish children during the COVID-19 pandemic. Arch Dis Child. 2022;107 (2):180-185. doi: 10.1136/archdischild-2020-321220. PubMed PMID:34045208 .
  13. Wetterslev, M, Møller, MH, Granholm, A, Haase, N, Hassager, C, Lange, T et al.. New-onset atrial fibrillation in the intensive care unit: Protocol for an international inception cohort study (AFIB-ICU). Acta Anaesthesiol Scand. 2021;65 (6):846-851. doi: 10.1111/aas.13827. PubMed PMID:33864378 .
  14. Nissilä, E, Hynninen, M, Reinikainen, M, Bendel, S, Suojaranta, R, Korhonen, AM et al.. Prevalence and impact of hazardous alcohol use in intensive care cohort: A multicenter, register-based study. Acta Anaesthesiol Scand. 2021;65 (8):1073-1078. doi: 10.1111/aas.13828. PubMed PMID:33840090 .
  15. Salmi, H, Harve-Rytsälä, H, Rautiainen, P, Pyörälä, S, Hästbacka, J. Overlooking the Obvious during the COVID-19 Pandemic: Dyspnoea with Asymmetric Breath Sounds in a Toddler. Case Rep Pediatr. 2021;2021 :8855962. doi: 10.1155/2021/8855962. PubMed PMID:33585047 PubMed Central PMC7852333.
  16. Pekkarinen, PT, Skrifvars, MB, Lievonen, V, Jakkula, P, Albrecht, L, Loisa, P et al.. Serum fibroblast growth factor 21 levels after out of hospital cardiac arrest are associated with neurological outcome. Sci Rep. 2021;11 (1):690. doi: 10.1038/s41598-020-80086-7. PubMed PMID:33436812 PubMed Central PMC7804444.
  17. Hästbacka, J, Kirkegaard, H, Søreide, E, Taccone, FS, Rasmussen, BS, Storm, C et al.. Severe or critical hypotension during post cardiac arrest care is associated with factors available on admission – a post hoc analysis of the TTH48 trial. J Crit Care. 2021;61 :186-190. doi: 10.1016/j.jcrc.2020.10.026. PubMed PMID:33181415 .
  18. Wihersaari, L, Ashton, NJ, Reinikainen, M, Jakkula, P, Pettilä, V, Hästbacka, J et al.. Neurofilament light as an outcome predictor after cardiac arrest: a post hoc analysis of the COMACARE trial. Intensive Care Med. 2021;47 (1):39-48. doi: 10.1007/s00134-020-06218-9. PubMed PMID:32852582 PubMed Central PMC7782453.

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