Functional Biomaterials for Biomedical Applications
NOTE: Oommen Lab is now at Cardiff University, UK. You can contact me at OommenO@cardiff.ac.uk
Research Goals: Our research focuses on harnessing the innate biological properties of extracellular matrix (ECM) polymers to design advanced biomaterials for biomedical applications. ECM polymers play a crucial role in regulating biological processes such as wound healing, inflammation modulation, tissue regeneration, stem cell proliferation, migration, and differentiation. To achieve our goal, we utilize both ECM-derived and synthetic polymers to create immunomodulatory nanomaterials for drug and nucleic acid delivery, as well as bulk hydrogels for tissue engineering and the creation of complex 3D tissue models. Our aim is to develop next-generation biomaterials that can improve patient outcomes and advance the field of biomedical engineering.
Research Goals
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Design ECM mimetic hydrogel with tunable viscoelasticity and degradation profile
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Tailor the immune response by functionalizing the scaffold with appropriate bioactive agents
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Utilize these bioactive scaffolds for tissue engineering, 3D cell culture, in-vitro disease modeling and stem cell delivery applications
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Design functional nanocarriers (metallic nanoparticles and polymeric micelles) derived from bioactive polymers for targeted drug or gene delivery applications
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Engineer therapeutic cells by layer-by-layer coating of stem cells with bioactive polymers or by gene silencing approach for enhanced in-vivo survival and function.
Funding received
Thank you for funding our research
