Publications

Publications 2023

Biomimetic polyelectrolyte coating of stem cells suppresses thrombotic activation and enhances its survival and function.

Biomaterials Advances, 2023, 147, 213331V. K. Rangasami, K. Asawa, Y. Teramura, K. L. Blanc, B. Nilsson, J. Hilborn, O. P. Varghese, O. P. Oommen

Biomaterials Advances, 2023, 147, 213331

Hyaluronic acid based next generation bioink for 3D bioprinting of human stem cell derived corneal stromal model with innervation

A. Moro, S. Samanta, L. Honkamäki, V. K. Rangasami, P. Puistola, M. Kauppila, S. Narkilahti, S. Miettinen, O. P. Oommen, H. Skottman

Biofabrications, 2023, 15 (1), 015020

2022

Heparin-derived theranostic nanoprobes overcome the blood-brain barrier and target glioma in murine model

S. Samanta, V. Le Joncour, O. Wegrzyniak, V. Rangasami, H. Ali-Loytty, T. Hong, R. K. Selvaraju, O. Aberg, J. Hilborn, P. Laakkonen, O. P. Varghese, O. Eriksson, H. Cabral, O. P. Oommen

Link: Advanced Therapeutics, 2022, 2200001

Bidirectional cell-matrix interaction dictates neuronal network formation in a brain mimetic 3D scaffold

S. Samanta, L. Ylä-Outinen, V. K. Rangasami, S. Narkilahti and O. P. Oommen

Acta Biomaterialia, 2022, 140, 314-323.

Interpenetrating gallol functionalized tissue adhesive hyaluronic acid hydrogel polarizes macrophages to an immunosuppressive phenotype

S. Samanta, V. K. Rangasami, H. Sarlus, J. R. K Samal, A. D. Evans, V. S Parihar, O. P. Varghese, R. A. Harris, O. P. Oommen

Acta Biomaterialia, 2022, 142, 36-48

Dynamic Covalent Crosslinked Hyaluronic Acid Hydrogels and Nanomaterials for Biomedical Applications

S. Wang, S. Tavakoli, R. P. Parvathaneni, G. N. Nawale, O. P Oommen, J. Hilborn, O. P. Varghese

Biomaterial Sciences, 2022, 10, 6399-6412

2021

An unexpected role of an extra phenolic hydroxyl on the chemical reactivity and bioactivity of catechol or gallol modified hyaluronic acid hydrogels

S. Samanta, V. K. Rangasami, N. A. Murugan, O. P. Varghese, O. P. Oommen

Polymer Chem, 2021,12 (20), 2987-2991

Redox responsive Pluronic micelle mediated delivery of functional siRNA: a modular nano-assembly for targeted delivery

S. Kadekar, G. N. Nawale, V. K. Rangasami, V. Le Joncour, P. Laakkonen, J. Hilborn, O. P. Varghese, O. P. Oommen

Biomaterials Science, 2021, 9 (11), 3939-3944

Pluronic Micelle-Mediated Tissue Factor Silencing Enhances Hemocompatibility, Stemness, Differentiation Potential, and Paracrine Signaling of Mesenchymal Stem Cells

V. K. Rangasami, G. Nawale, K. Asawa, S. Kadekar, S. Samanta, B. Nilsson, K. N Ekdahl, S. Miettinen, J. Hilborn, Y. Teramura, O. P. Varghese, O. P. Oommen

Biomacromolecules, 2021, 22 (5), 1980-1989

Discrepancies on the role of oxygen gradient and culture condition on mesenchymal stem cell fate

J. R. K. Samal, V. K. Rangasami, S. Samanta, O. P. Varghese, O. P. Oommen

Adv. Healthcare Materials. 2021, 2002058

Harnessing hyaluronic acid-based nanoparticles for combination therapy: A novel approach for suppressing systemic inflammation and to promote antitumor macrophage polarization

V. K. Rangasami, S. Samanta, V. S, Parihar, K. Asawa, K. Zhu, O. P. Varghese, B. Nilsson, J. Hilborn, R. A. Harris, O. P. Oommen

Carbohydrate Pol., 254, 2021, 117291

Hyaluronic acid-functionalized nanomicelles enhance SAHA efficacy in 3D endometrial cancer models

K. Edwards, S. Yao, S. Pisano, V. Feltracco, K. Brusehafer, S. Samanta, O. P Oommen, S. A. Gazze, R. Paravati, H. Maddison, C. Li, D. Gonzalez, R. S. Conlan, L. Francis

Cancers, 2021, 13 (16), 4032

Streptococcus pneumoniae pneumolysin and neuraminidase A convert high-density lipoproteins into pro-atherogenic particles

S. Syed, E. Nissilä, H. Ruhanen, S. Fudo, M. O. Gaytán, S. P Sihvo, M. B Lorey, J. Metso, K. Öörni, S. J King, O. P. Oommen, M. Jauhiainen, S. Meri, R. Käkelä, K. Haapasalo

Iscience, 2021 24 (6), 102535

ILC1 drive intestinal epithelial and matrix remodelling

G. M. Jowett, M. D. A. Norman, T. T. L. Yu, P. Rosell Arévalo, D. Hoogland, S. T. Lust, E. Read, E. Hamrud, N. J. Walters, U. Niazi, M. W. H. Chung, D. Marciano, O. S. Omer, T. Zabinski, D. Danovi, G. M. Lord, J. Hilborn, N. D. Evans, C. A. Dreiss, L. Bozec, O. P. Oommen, C. D. Lorenz, R. M. P. da Silva, J. F. Neves, E. Gentleman

Nature Materials 2021 20 (2), 250-259

2020

Hyaluronan derived nanoparticles for the delivery of Simvastatin: Overcoming the drug adverse effect for skeletal muscle engineered tissue constructs

J. M. Jones, D. J. Player, N. R. W. Martin, V. K. Rangasami, S. Samanta, J. Hilborn, M. P. Lewis, O. P. Oommen, & V. Mudera

Biomaterial Sciences, 2020, (8), 1, 302-320

2019

Unexpected role of hyaluronic acid in trafficking siRNA across cellular barrier: First biomimetic, anionic, non-viral transfection method

M. Paidikondala, V. K. Rangasami, G. N. Nawale, T. Casalini, G. Perale, S. Kadekar, G. Mohanty, T. Salminen, O. P. Oommen, O. P. Varghese

Angew. Chem. Int. Edn., 2019, 58 (9), 2815-2819

Tissue Adhesive Hyaluronic Acid Hydrogels for Sutureless Stem Cell Delivery and Regeneration of Corneal Epithelium and Stroma

L. Koivusalo, M. Kauppila, T. Ilmarinen, S. Samanta, V. S. Parihar, S. Miettinen, O. P. Oommen, H. Skottman

Biomaterials, 2019, 225, 119516

First Aldol Cross-linked Hyaluronic Acid Hydrogel: Fast and Hydrolytically Stable Hydrogel with Tissue Adhesive Properties

D. Bermejo-Velasco, S. Kadekar, M. V. T. da Costa, O. P. Oommen, K. Gamstedt, J. Hilborn, O. P. Varghese

ACS Applied Materials and Interface, 2019, 11 (41), 38232-38239

Influence of ions to modulate hydrazone and oxime reaction kinetics to obtain dynamically cross-linked hyaluronic acid hydrogels

S. Wang, G. N. Nawale, O. P. Oommen, J. Hilborn, O. P. Varghese

Polym. Chem., 2019 10, 4322-4327

Carbon nanotube doped pericardial matrix derived electroconductive biohybrid hydrogel for cardiac tissue engineering

K. Roshanbinfar, Z. Mohammadi, A. S-M Mesgar, M. M. Dehghan, O. P. Oommen, J. Hilborn, F. B. Engel

Biomaterial Sciences, 2019, 7, 3906-3917

Modulating thiol pKa promotes disulfide formation at physiological pH: An elegant strategy to design disulfide crosslinked hyaluronic acid hydrogels

D. Bermejo-Velasco, A. Azemar, O. P. Oommen, J. Hilborn, O. P Varghese

Biomacromolecules, 2019, 20, 1412–1420

Synthetic design of asymmetric miRNA with engineered 3′-overhang to improve strand selection

S. Kadekar, G. N. Nawale, K. Karlsson, C. Ålander, O. P. Oommen, O. P. Varghese

Mol. Ther. Nucleic Acids, 2019, 16, 597-604

2018

Bi-directional cell-pericellular matrix interactions direct stem cell fate

S. A. Ferreira, M. S. Motwani, P. A. Faull, A. J. Seymour, T. T.L. Yu, M. Enayati, D. K. Taheem, E. M. Kania, O. P. Oommen, T. Ahmed, S. Loaiza, K. Parzych, F. Dazzi, H. W. Auner, O. P. Varghese, F. Festy, A. E. Grigoriadis, A. P. Snijders, L. Bozec, E. Gentleman

Nature Communications, 2018, 9, 4049

Thiazolidine chemistry revisited: A fast, efficient and stable click-type reaction at physiological pH

D. Bermejo-Velasco, G. N. Nawale, O. P. Oommen J. Hilborn, O. P. Varghese

Chemical Commun., 2018, 54 (88), 12507-12510

Synthetic design of growth factor sequestering extracellular matrix mimetic hydrogel for promoting in vivo bone formation

H. Yan, T. Casalini, G. Hulsart-Billström, S. Wang, O. P. Oommen, M. Salvalaglio, S. Larsson, J. Hilborn, O. P. Varghese

Biomaterials 2018, 161, 190-202

Saline Accelerates Oxime Reaction with Aldehyde and Keto Substrates at Physiological pH

S. Wang, G. N. Nawale, S. Kadekar, O. P. Oommen, N. K. Jena, S. Chakraborty, J. Hilborn, O. P. Varghese

Scientific Reports, 2018, 8, 2193

Injectable and Thermoresponsive Pericardial Matrix Derived Conductive Scaffold for Cardiac Applications

K. Roshanbinfar, J. Hilborn, O. P. Varghese, O. P. Oommen

RSC Advances, 2017, 7, 31980-31988

Gold Nanoparticles Approach to Detect Chondroitin Sulphate and Hyaluronic Acid Urothelial Coating

G. Guelfi, V. Stefanetti, D. Zampini, O. P. Oommen, G. Brecchia, C. Dall'Aglio, R. Arcelli, G. Cochetti, A. Boni, E. Mearini

Scientific Reports, 2017, 7, 10355