Glycosaminoglycans' for brain health: Harnessing Glycosaminoglycan based biomaterials for treating central nervous system diseases and in-vitro modeling
A. D Evans, N. Pournoori, E. Saksala, O. P. Oommen
Publications
Publications 2024
Fine-tuning Dynamic Crosslinking for Enhanced 3D Bioprinting of Hyaluronic Acid Hydrogels
S. Tavakoli, N. Krishnan, H. Mokhtari, O. P. Oommen, and O. P. Varghese
Mimic miRNA and Anti-miRNA Activated Scaffolds as a Therapeutic Strategy to Promote Bone, Cartilage, and Skin Regeneration
G. Guelfi, C. Capaccia, P. Anipchenko, F. Ciancabilla, O. P. OOMMEN, A. Bufalari, M. Zerani, M. Maranesi
Publications 2023
Biomimetic polyelectrolyte coating of stem cells suppresses thrombotic activation and enhances its survival and function.
Biomaterials Advances, 2023, 147, 213331V. K. Rangasami, K. Asawa, Y. Teramura, K. L. Blanc, B. Nilsson, J. Hilborn, O. P. Varghese, O. P. Oommen
Hyaluronic acid based next generation bioink for 3D bioprinting of human stem cell derived corneal stromal model with innervation
A. Moro, S. Samanta, L. Honkamäki, V. K. Rangasami, P. Puistola, M. Kauppila, S. Narkilahti, S. Miettinen, O. P. Oommen, H. Skottman
2022
Heparin-derived theranostic nanoprobes overcome the blood-brain barrier and target glioma in murine model
S. Samanta, V. Le Joncour, O. Wegrzyniak, V. Rangasami, H. Ali-Loytty, T. Hong, R. K. Selvaraju, O. Aberg, J. Hilborn, P. Laakkonen, O. P. Varghese, O. Eriksson, H. Cabral, O. P. Oommen
Bidirectional cell-matrix interaction dictates neuronal network formation in a brain mimetic 3D scaffold
S. Samanta, L. Ylä-Outinen, V. K. Rangasami, S. Narkilahti and O. P. Oommen
Interpenetrating gallol functionalized tissue adhesive hyaluronic acid hydrogel polarizes macrophages to an immunosuppressive phenotype
S. Samanta, V. K. Rangasami, H. Sarlus, J. R. K Samal, A. D. Evans, V. S Parihar, O. P. Varghese, R. A. Harris, O. P. Oommen
Dynamic Covalent Crosslinked Hyaluronic Acid Hydrogels and Nanomaterials for Biomedical Applications
S. Wang, S. Tavakoli, R. P. Parvathaneni, G. N. Nawale, O. P Oommen, J. Hilborn, O. P. Varghese
2021
An unexpected role of an extra phenolic hydroxyl on the chemical reactivity and bioactivity of catechol or gallol modified hyaluronic acid hydrogels
S. Samanta, V. K. Rangasami, N. A. Murugan, O. P. Varghese, O. P. Oommen
Redox responsive Pluronic micelle mediated delivery of functional siRNA: a modular nano-assembly for targeted delivery
S. Kadekar, G. N. Nawale, V. K. Rangasami, V. Le Joncour, P. Laakkonen, J. Hilborn, O. P. Varghese, O. P. Oommen
Pluronic Micelle-Mediated Tissue Factor Silencing Enhances Hemocompatibility, Stemness, Differentiation Potential, and Paracrine Signaling of Mesenchymal Stem Cells
V. K. Rangasami, G. Nawale, K. Asawa, S. Kadekar, S. Samanta, B. Nilsson, K. N Ekdahl, S. Miettinen, J. Hilborn, Y. Teramura, O. P. Varghese, O. P. Oommen
Discrepancies on the role of oxygen gradient and culture condition on mesenchymal stem cell fate
J. R. K. Samal, V. K. Rangasami, S. Samanta, O. P. Varghese, O. P. Oommen
Harnessing hyaluronic acid-based nanoparticles for combination therapy: A novel approach for suppressing systemic inflammation and to promote antitumor macrophage polarization
V. K. Rangasami, S. Samanta, V. S, Parihar, K. Asawa, K. Zhu, O. P. Varghese, B. Nilsson, J. Hilborn, R. A. Harris, O. P. Oommen
Hyaluronic acid-functionalized nanomicelles enhance SAHA efficacy in 3D endometrial cancer models
K. Edwards, S. Yao, S. Pisano, V. Feltracco, K. Brusehafer, S. Samanta, O. P Oommen, S. A. Gazze, R. Paravati, H. Maddison, C. Li, D. Gonzalez, R. S. Conlan, L. Francis
Streptococcus pneumoniae pneumolysin and neuraminidase A convert high-density lipoproteins into pro-atherogenic particles
S. Syed, E. Nissilä, H. Ruhanen, S. Fudo, M. O. Gaytán, S. P Sihvo, M. B Lorey, J. Metso, K. Öörni, S. J King, O. P. Oommen, M. Jauhiainen, S. Meri, R. Käkelä, K. Haapasalo
ILC1 drive intestinal epithelial and matrix remodelling
G. M. Jowett, M. D. A. Norman, T. T. L. Yu, P. Rosell Arévalo, D. Hoogland, S. T. Lust, E. Read, E. Hamrud, N. J. Walters, U. Niazi, M. W. H. Chung, D. Marciano, O. S. Omer, T. Zabinski, D. Danovi, G. M. Lord, J. Hilborn, N. D. Evans, C. A. Dreiss, L. Bozec, O. P. Oommen, C. D. Lorenz, R. M. P. da Silva, J. F. Neves, E. Gentleman
2020
Hyaluronan derived nanoparticles for the delivery of Simvastatin: Overcoming the drug adverse effect for skeletal muscle engineered tissue constructs
J. M. Jones, D. J. Player, N. R. W. Martin, V. K. Rangasami, S. Samanta, J. Hilborn, M. P. Lewis, O. P. Oommen, & V. Mudera
2019
Unexpected role of hyaluronic acid in trafficking siRNA across cellular barrier: First biomimetic, anionic, non-viral transfection method
M. Paidikondala, V. K. Rangasami, G. N. Nawale, T. Casalini, G. Perale, S. Kadekar, G. Mohanty, T. Salminen, O. P. Oommen, O. P. Varghese
Tissue Adhesive Hyaluronic Acid Hydrogels for Sutureless Stem Cell Delivery and Regeneration of Corneal Epithelium and Stroma
L. Koivusalo, M. Kauppila, T. Ilmarinen, S. Samanta, V. S. Parihar, S. Miettinen, O. P. Oommen, H. Skottman
First Aldol Cross-linked Hyaluronic Acid Hydrogel: Fast and Hydrolytically Stable Hydrogel with Tissue Adhesive Properties
D. Bermejo-Velasco, S. Kadekar, M. V. T. da Costa, O. P. Oommen, K. Gamstedt, J. Hilborn, O. P. Varghese
Influence of ions to modulate hydrazone and oxime reaction kinetics to obtain dynamically cross-linked hyaluronic acid hydrogels
S. Wang, G. N. Nawale, O. P. Oommen, J. Hilborn, O. P. Varghese
Carbon nanotube doped pericardial matrix derived electroconductive biohybrid hydrogel for cardiac tissue engineering
K. Roshanbinfar, Z. Mohammadi, A. S-M Mesgar, M. M. Dehghan, O. P. Oommen, J. Hilborn, F. B. Engel
Modulating thiol pKa promotes disulfide formation at physiological pH: An elegant strategy to design disulfide crosslinked hyaluronic acid hydrogels
D. Bermejo-Velasco, A. Azemar, O. P. Oommen, J. Hilborn, O. P Varghese
Synthetic design of asymmetric miRNA with engineered 3′-overhang to improve strand selection
S. Kadekar, G. N. Nawale, K. Karlsson, C. Ålander, O. P. Oommen, O. P. Varghese
2018
Bi-directional cell-pericellular matrix interactions direct stem cell fate
S. A. Ferreira, M. S. Motwani, P. A. Faull, A. J. Seymour, T. T.L. Yu, M. Enayati, D. K. Taheem, E. M. Kania, O. P. Oommen, T. Ahmed, S. Loaiza, K. Parzych, F. Dazzi, H. W. Auner, O. P. Varghese, F. Festy, A. E. Grigoriadis, A. P. Snijders, L. Bozec, E. Gentleman
Thiazolidine chemistry revisited: A fast, efficient and stable click-type reaction at physiological pH
D. Bermejo-Velasco, G. N. Nawale, O. P. Oommen J. Hilborn, O. P. Varghese
Synthetic design of growth factor sequestering extracellular matrix mimetic hydrogel for promoting in vivo bone formation
H. Yan, T. Casalini, G. Hulsart-Billström, S. Wang, O. P. Oommen, M. Salvalaglio, S. Larsson, J. Hilborn, O. P. Varghese
Saline Accelerates Oxime Reaction with Aldehyde and Keto Substrates at Physiological pH
S. Wang, G. N. Nawale, S. Kadekar, O. P. Oommen, N. K. Jena, S. Chakraborty, J. Hilborn, O. P. Varghese
Injectable and Thermoresponsive Pericardial Matrix Derived Conductive Scaffold for Cardiac Applications
K. Roshanbinfar, J. Hilborn, O. P. Varghese, O. P. Oommen
Gold Nanoparticles Approach to Detect Chondroitin Sulphate and Hyaluronic Acid Urothelial Coating
G. Guelfi, V. Stefanetti, D. Zampini, O. P. Oommen, G. Brecchia, C. Dall'Aglio, R. Arcelli, G. Cochetti, A. Boni, E. Mearini