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Clinical Cardiology

PubMed publications

2024

  1. Järvensivu-Koivunen, M, Hernesniemi, J, Tynkkynen, J. Smoking and sudden cardiac death in patients with previous coronary artery disease. Coron Artery Dis. 2025;36 (1):59-64. doi: 10.1097/MCA.0000000000001421. PubMed PMID:39652651 PubMed Central PMC11617078.
  2. Allara, E, Bell, S, Smith, R, Keene, SJ, Gill, D, Gaziano, L et al.. Novel loci and biomedical consequences of iron homoeostasis variation. Commun Biol. 2024;7 (1):1631. doi: 10.1038/s42003-024-07115-3. PubMed PMID:39643614 PubMed Central PMC11624196.
  3. Salo, V, Määttä, J, Sliz, E, FinnGen, Reimann, E, Mägi, R et al.. Genome-wide meta-analysis conducted in three large biobanks expands the genetic landscape of lumbar disc herniations. Nat Commun. 2024;15 (1):9424. doi: 10.1038/s41467-024-53467-z. PubMed PMID:39511132 PubMed Central PMC11544010.
  4. Järvensivu-Koivunen, M, Kallonen, A, van Gils, M, Lyytikäinen, LP, Tynkkynen, J, Hernesniemi, J et al.. Predicting long-term risk of sudden cardiac death with automatic computer-interpretations of electrocardiogram. Front Cardiovasc Med. 2024;11 :1439069. doi: 10.3389/fcvm.2024.1439069. PubMed PMID:39507385 PubMed Central PMC11537987.
  5. Söderlund, M, Huhtamo, H, Protto, S, Hernesniemi, JA, Vakhitov, D, Oksala, N et al.. Magnetic Resonance Imaging – Derived Psoas Muscle Area and Survival in Patients Treated Invasively for Peripheral Arterial Disease. Scand J Surg. 2024; :14574969241282485. doi: 10.1177/14574969241282485. PubMed PMID:39431407 .
  6. Pasanen, A, Karjalainen, MK, Korppi, M, Hallman, M, Rämet, M, Research Project FinnGen
    et al.. Genetic susceptibility to acute viral bronchiolitis. J Infect Dis. 2024; :. doi: 10.1093/infdis/jiae467. PubMed PMID:39299705 .
  7. Laukkanen, JA, Kunutsor, SK, Immonen, J, Hernesniemi, J, Karvanen, J, Eskola, M et al.. Diabetes and mortality risk in patients undergoing coronary angiography: The KARDIO study. Catheter Cardiovasc Interv. 2024;104 (4):743-750. doi: 10.1002/ccd.31212. PubMed PMID:39219466 .
  8. Hernesniemi, JA, Pukkila, T, Molkkari, M, Nikus, K, Lyytikäinen, LP, Lehtimäki, T et al.. Prediction of Sudden Cardiac Death With Ultra-Short-Term Heart Rate Fluctuations. JACC Clin Electrophysiol. 2024;10 (9):2010-2020. doi: 10.1016/j.jacep.2024.04.018. PubMed PMID:38878016 .
  9. Vuoksimaa, E, Saari, TT, Aaltonen, A, Aaltonen, S, Herukka, SK, Iso-Markku, P et al.. TWINGEN: protocol for an observational clinical biobank recall and biomarker cohort study to identify Finnish individuals with high risk of Alzheimer’s disease. BMJ Open. 2024;14 (6):e081947. doi: 10.1136/bmjopen-2023-081947. PubMed PMID:38866570 PubMed Central PMC11177688.
  10. Hautamäki, M, Järvensivu-Koivunen, M, Lyytikäinen, LP, Eskola, M, Lehtimäki, T, Nikus, K et al.. The association between GRACE score at admission for myocardial infarction and the incidence of sudden cardiac arrests in long-term follow-up – the MADDEC study. Scand Cardiovasc J. 2024;58 (1):2335905. doi: 10.1080/14017431.2024.2335905. PubMed PMID:38557164 .
  11. Mars, N, Kerminen, S, Tamlander, M, Pirinen, M, Jakkula, E, Aaltonen, K et al.. Comprehensive Inherited Risk Estimation for Risk-Based Breast Cancer Screening in Women. J Clin Oncol. 2024;42 (13):1477-1487. doi: 10.1200/JCO.23.00295. PubMed PMID:38422475 PubMed Central PMC11095905.
  12. Järvensivu-Koivunen, M, Tynkkynen, J, Oksala, N, Eskola, M, Hernesniemi, J. Ventricular Arrhythmias and Hemodynamic Collapse During Acute Coronary Syndrome- Increased Risk for Sudden Cardiac Death?. Eur J Prev Cardiol. 2024; :. doi: 10.1093/eurjpc/zwae074. PubMed PMID:38394335 .
  13. Youssef, O, Loukola, A, Zidi-Mouaffak, YHS, Tamlander, M, Ruotsalainen, S, Kilpeläinen, E et al.. High-Resolution Genotyping of Formalin-Fixed Tissue Accurately Estimates Polygenic Risk Scores in Human Diseases. Lab Invest. 2024;104 (4):100325. doi: 10.1016/j.labinv.2024.100325. PubMed PMID:38220043 .
  14. Nurkkala, JM, Aittokallio, J, FinnGen
    , Kauko, A, Niiranen, T. Sex-specific genetic risks for adverse outcomes after coronary revascularization procedures. Interdiscip Cardiovasc Thorac Surg. 2024;38 (1):. doi: 10.1093/icvts/ivae006. PubMed PMID:38216540 PubMed Central PMC10799751.
  15. Sirén, M, Leivo, J, Anttonen, E, Jolly, SS, Dzavik, V, Koivumäki, J et al.. The prognostic significance of single-lead ST-segment resolution in ST-segment elevation myocardial infarction patients treated with primary PCI – A substudy of the randomized TOTAL trial. Am Heart J. 2024;269 :149-157. doi: 10.1016/j.ahj.2023.12.009. PubMed PMID:38109987 .
  16. Valkkio, S, Kuoppala, S, Lindström, I, Khan, N, Sioris, T, Laurikka, J et al.. Computed tomography -defined sarcopenia is associated with long-term survival among patients undergoing open thoracic aortic reconstruction. Scand J Surg. 2024;113 (2):150-159. doi: 10.1177/14574969231213758. PubMed PMID:38095018 .

Search PubMed

2023

  1. Sirén, M, Leivo, J, Anttonen, E, Jolly, SS, Dzavik, V, Koivumäki, J et al.. The prognostic significance of single-lead ST-segment resolution in ST-segment elevation myocardial infarction patients treated with primary PCI – A substudy of the randomized TOTAL trial. Am Heart J. 2024;269 :149-157. doi: 10.1016/j.ahj.2023.12.009. PubMed PMID:38109987 .
  2. Valkkio, S, Kuoppala, S, Lindström, I, Khan, N, Sioris, T, Laurikka, J et al.. Computed tomography -defined sarcopenia is associated with long-term survival among patients undergoing open thoracic aortic reconstruction. Scand J Surg. 2024;113 (2):150-159. doi: 10.1177/14574969231213758. PubMed PMID:38095018 .
  3. Parkkari, E, Vanhala, V, Lindberg, R, Tynkkynen, J, Hernesniemi, J. The incidence of atrial fibrillation, new oral anticoagulation, stroke, and significant bleeds in patients receiving a new dual-chamber pacemaker. Int J Cardiol Heart Vasc. 2023;49 :101307. doi: 10.1016/j.ijcha.2023.101307. PubMed PMID:38053982 PubMed Central PMC10694644.
  4. Nurmi, AK, Pelttari, LM, Kiiski, JI, Khan, S, Nurmikolu, M, Suvanto, M et al.. NTHL1 is a recessive cancer susceptibility gene. Sci Rep. 2023;13 (1):21127. doi: 10.1038/s41598-023-47441-w. PubMed PMID:38036545 PubMed Central PMC10689455.
  5. Järvinen, O, Tynkkynen, JT, Virtanen, M, Maaranen, P, Lindström, I, Vakhitov, D et al.. Psoas muscle quantified muscle status and long-term mortality after cardiovascular interventions. Ann Med. 2023;55 (2):2259798. doi: 10.1080/07853890.2023.2259798. PubMed PMID:37738519 PubMed Central PMC10519254.
  6. Erkkilä, O, Hernesniemi, J, Tynkkynen, J. The Association Between Digoxin Use and Long-Term Mortality After Acute Coronary Syndrome. Am J Cardiol. 2023;204 :377-382. doi: 10.1016/j.amjcard.2023.06.125. PubMed PMID:37573617 .
  7. Julkunen, V, Schwarz, C, Kalapudas, J, Hallikainen, M, Piironen, AK, Mannermaa, A et al.. A FinnGen pilot clinical recall study for Alzheimer’s disease. Sci Rep. 2023;13 (1):12641. doi: 10.1038/s41598-023-39835-7. PubMed PMID:37537264 PubMed Central PMC10400697.
  8. Charlton, PH, Allen, J, Bailón, R, Baker, S, Behar, JA, Chen, F et al.. The 2023 wearable photoplethysmography roadmap. Physiol Meas. 2023;44 (11):. doi: 10.1088/1361-6579/acead2. PubMed PMID:37494945 PubMed Central PMC10686289.
  9. Hurskainen, M, Tynkkynen, J, Eskola, M, Lehtimäki, T, Hernesniemi, J. Risk Factors for Ischemic Stroke After Acute Coronary Syndrome. J Am Heart Assoc. 2023;12 (14):e028787. doi: 10.1161/JAHA.122.028787. PubMed PMID:37421266 PubMed Central PMC10382101.
  10. Viippola, E, Kuitunen, S, Rodosthenous, RS, Vabalas, A, Hartonen, T, Vartiainen, P et al.. Data Resource Profile: Nationwide registry data for high-throughput epidemiology and machine learning (FinRegistry). Int J Epidemiol. 2023;52 (4):e195-e200. doi: 10.1093/ije/dyad091. PubMed PMID:37365732 PubMed Central PMC10396416.
  11. Ågren, R, Patil, S, Zhou, X, FinnGen., Sahlholm, K, Pääbo, S et al.. Major Genetic Risk Factors for Dupuytren’s Disease Are Inherited From Neandertals. Mol Biol Evol. 2023;40 (6):. doi: 10.1093/molbev/msad130. PubMed PMID:37315093 PubMed Central PMC10266526.
  12. Jones, SE, Maisha, FI, Strausz, SJ, Lammi, V, Cade, BE, Tervi, A et al.. The public health impact of poor sleep on severe COVID-19, influenza and upper respiratory infections. EBioMedicine. 2023;93 :104630. doi: 10.1016/j.ebiom.2023.104630. PubMed PMID:37301713 PubMed Central PMC10248098.
  13. Tyrmi, JS, Kaartokallio, T, Lokki, AI, Jääskeläinen, T, Kortelainen, E, Ruotsalainen, S et al.. Genetic Risk Factors Associated With Preeclampsia and Hypertensive Disorders of Pregnancy. JAMA Cardiol. 2023;8 (7):674-683. doi: 10.1001/jamacardio.2023.1312. PubMed PMID:37285119 PubMed Central PMC10248811.
  14. Miller, EC, Kauko, A, Tom, SE, Laivuori, H, Niiranen, T, Bello, NA et al.. Risk of Midlife Stroke After Adverse Pregnancy Outcomes: The FinnGen Study. Stroke. 2023;54 (7):1798-1805. doi: 10.1161/STROKEAHA.123.043052. PubMed PMID:37212139 PubMed Central PMC10330298.
  15. Ollila, HM, Sharon, E, Lin, L, Sinnott-Armstrong, N, Ambati, A, Yogeshwar, SM et al.. Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy. Nat Commun. 2023;14 (1):2709. doi: 10.1038/s41467-023-36120-z. PubMed PMID:37188663 PubMed Central PMC10185546.
  16. Lahti, R, Rankinen, J, Eskola, M, Nikus, K, Hernesniemi, J. Intraventricular conduction delays as a predictor of mortality in acute coronary syndromes. Eur Heart J Acute Cardiovasc Care. 2023;12 (7):430-436. doi: 10.1093/ehjacc/zuad031. PubMed PMID:36989402 PubMed Central PMC10328435.
  17. Antikainen, E, Linnosmaa, J, Umer, A, Oksala, N, Eskola, M, van Gils, M et al.. Transformers for cardiac patient mortality risk prediction from heterogeneous electronic health records. Sci Rep. 2023;13 (1):3517. doi: 10.1038/s41598-023-30657-1. PubMed PMID:36864069 PubMed Central PMC9978282.
  18. Saarinen, HJ, Joutsen, A, Korpi, K, Halkola, T, Nurmi, M, Hernesniemi, J et al.. Wrist-worn device combining PPG and ECG can be reliably used for atrial fibrillation detection in an outpatient setting. Front Cardiovasc Med. 2023;10 :1100127. doi: 10.3389/fcvm.2023.1100127. PubMed PMID:36844740 PubMed Central PMC9949528.
  19. Sliz, E, Tyrmi, JS, Rahmioglu, N, Zondervan, KT, Becker, CM, FinnGen et al.. Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata. Nat Commun. 2023;14 (1):542. doi: 10.1038/s41467-023-35974-7. PubMed PMID:36726022 PubMed Central PMC9892568.
  20. Koivunen, M, Tynkkynen, J, Oksala, N, Eskola, M, Hernesniemi, J. Incidence of sudden cardiac arrest and sudden cardiac death after unstable angina pectoris and myocardial infarction. Am Heart J. 2023;257 :9-19. doi: 10.1016/j.ahj.2022.11.009. PubMed PMID:36384178 .
  21. Lauksio, I, Wallenius, L, Lindström, I, Kärkkäinen, JM, Khan, N, Hernesniemi, J et al.. Multivariable Analysis of Pre-operative Brain Atrophy as a Predictor of Long Term Mortality After Carotid Endarterectomy. Eur J Vasc Endovasc Surg. 2023;65 (3):339-345. doi: 10.1016/j.ejvs.2022.10.001. PubMed PMID:36209966 .

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2022

  1. Koivunen, M, Tynkkynen, J, Oksala, N, Eskola, M, Hernesniemi, J. Incidence of sudden cardiac arrest and sudden cardiac death after unstable angina pectoris and myocardial infarction. Am Heart J. 2023;257 :9-19. doi: 10.1016/j.ahj.2022.11.009. PubMed PMID:36384178 .
  2. Laukkanen, JA, Kunutsor, SK, Hernesniemi, J, Immonen, J, Eskola, M, Zaccardi, F et al.. Underweight and obesity are related to higher mortality in patients undergoing coronary angiography: The KARDIO invasive cardiology register study. Catheter Cardiovasc Interv. 2022;100 (7):1242-1251. doi: 10.1002/ccd.30463. PubMed PMID:36378689 PubMed Central PMC10098486.
  3. Hurskainen, M, Tynkkynen, J, Eskola, M, Hernesniemi, J. Incidence of stroke and mortality due to stroke after acute coronary syndrome. J Stroke Cerebrovasc Dis. 2022;31 (12):106842. doi: 10.1016/j.jstrokecerebrovasdis.2022.106842. PubMed PMID:36309003 .
  4. Lauksio, I, Wallenius, L, Lindström, I, Kärkkäinen, JM, Khan, N, Hernesniemi, J et al.. Multivariable Analysis of Pre-operative Brain Atrophy as a Predictor of Long Term Mortality After Carotid Endarterectomy. Eur J Vasc Endovasc Surg. 2023;65 (3):339-345. doi: 10.1016/j.ejvs.2022.10.001. PubMed PMID:36209966 .
  5. Rodosthenous, RS, Niemi, MEK, Kallio, L, Perala, M, Terho, P, Knopp, T et al.. Recontacting biobank participants to collect lifestyle, behavioural and cognitive information via online questionnaires: lessons from a pilot study within FinnGen. BMJ Open. 2022;12 (10):e064695. doi: 10.1136/bmjopen-2022-064695. PubMed PMID:36198465 PubMed Central PMC9535212.
  6. Hernesniemi, JA. Dawn of the Era of Individualized Genetic Profiling in the Prevention of Sudden Cardiac Death. J Am Coll Cardiol. 2022;80 (9):884-886. doi: 10.1016/j.jacc.2022.06.016. PubMed PMID:36007986 .
  7. Lahti, R, Rankinen, J, Lyytikäinen, LP, Eskola, M, Nikus, K, Hernesniemi, J et al.. High-risk ECG patterns in ST elevation myocardial infarction for mortality prediction. J Electrocardiol. 2022;74 :13-19. doi: 10.1016/j.jelectrocard.2022.07.068. PubMed PMID:35907279 .
  8. Nurminen, J, Pérez-Riera, AR, de Luna, AB, Nikus, K, Lyytikäinen, LP, Huhtala, H et al.. The S1S2S3 electrocardiographic pattern – Prevalence and relation to cardiovascular and pulmonary diseases in the general population. J Electrocardiol. 2022;73 :113-119. doi: 10.1016/j.jelectrocard.2022.07.003. PubMed PMID:35839706 .
  9. Istolahti, T, Eranti, A, Huhtala, H, Tynkkynen, J, Lyytikäinen, LP, Kähönen, M et al.. Interatrial block and P terminal force in the general population – Longitudinal changes, risk factors and prognosis. J Electrocardiol. 2022;73 :12-20. doi: 10.1016/j.jelectrocard.2022.04.006. PubMed PMID:35533410 .
  10. Tikkanen, JT, Kentta, T, Porthan, K, Anttonen, O, Eranti, A, Aro, AL et al.. Risk of sudden cardiac death associated with QRS, QTc, and JTc intervals in the general population. Heart Rhythm. 2022;19 (8):1297-1303. doi: 10.1016/j.hrthm.2022.04.016. PubMed PMID:35472593 .
  11. Rankinen, J, Haataja, P, Lyytikäinen, LP, Huhtala, H, Lehtimäki, T, Kähönen, M et al.. Prevalence and long-term prognostic implications of prolonged QRS duration in left ventricular hypertrophy: a population-based observational cohort study. BMJ Open. 2022;12 (2):e053477. doi: 10.1136/bmjopen-2021-053477. PubMed PMID:35228283 PubMed Central PMC8886432.
  12. Numminen, A, Penttilä, T, Arola, O, Inkovaara, J, Oksala, N, Mäkynen, H et al.. Treatment success and its predictors as well as the complications of catheter ablation for atrial fibrillation in a high-volume centre. J Interv Card Electrophysiol. 2022;63 (2):357-367. doi: 10.1007/s10840-021-01011-0. PubMed PMID:34060008 PubMed Central PMC8983498.

Search PubMed

2021

  1. Hautamäki, M, Lyytikäinen, LP, Eskola, M, Lehtimäki, T, Nikus, K, Oksala, N et al.. Prehospital Adenosine Diphosphate Receptor Blocker Use, Culprit Artery Flow, and Mortality in STEMI: The MADDEC Study. Clin Drug Investig. 2021;41 (7):605-613. doi: 10.1007/s40261-021-01045-2. PubMed PMID:34101137 PubMed Central PMC8245391.
  2. Numminen, A, Penttilä, T, Arola, O, Inkovaara, J, Oksala, N, Mäkynen, H et al.. Treatment success and its predictors as well as the complications of catheter ablation for atrial fibrillation in a high-volume centre. J Interv Card Electrophysiol. 2022;63 (2):357-367. doi: 10.1007/s10840-021-01011-0. PubMed PMID:34060008 PubMed Central PMC8983498.
  3. Lindström, I, Protto, S, Khan, N, Väärämäki, S, Oksala, N, Hernesniemi, J et al.. Statin use, development of sarcopenia, and long-term survival after endovascular aortic repair. J Vasc Surg. 2021;74 (5):1651-1658.e1. doi: 10.1016/j.jvs.2021.04.054. PubMed PMID:34019985 .
  4. Heiskanen, JS, Hernesniemi, JA, Ruohonen, S, Hutri-Kähönen, N, Kähönen, M, Jokinen, E et al.. Influence of early-life body mass index and systolic blood pressure on left ventricle in adulthood – the Cardiovascular Risk in Young Finns Study. Ann Med. 2021;53 (1):160-168. doi: 10.1080/07853890.2020.1849785. PubMed PMID:33238748 PubMed Central PMC7877918.
  5. Istolahti, T, Lyytikäinen, LP, Huhtala, H, Nieminen, T, Kähönen, M, Lehtimäki, T et al.. The prognostic significance of T-wave inversion according to ECG lead group during long-term follow-up in the general population. Ann Noninvasive Electrocardiol. 2021;26 (1):e12799. doi: 10.1111/anec.12799. PubMed PMID:32975832 PubMed Central PMC7816818.
  6. Rankinen, J, Haataja, P, Lyytikäinen, LP, Huhtala, H, Lehtimäki, T, Kähönen, M et al.. Long-term outcome of intraventricular conduction delays in the general population. Ann Noninvasive Electrocardiol. 2021;26 (1):e12788. doi: 10.1111/anec.12788. PubMed PMID:32804416 PubMed Central PMC7816813.
  7. Lauksio, I, Lindström, I, Khan, N, Sillanpää, N, Hernesniemi, J, Oksala, N et al.. Brain atrophy predicts mortality after mechanical thrombectomy of proximal anterior circulation occlusion. J Neurointerv Surg. 2021;13 (5):415-420. doi: 10.1136/neurintsurg-2020-016168. PubMed PMID:32620574 .
  8. Vänni, V, Turtiainen, J, Kaustio, U, Toivanen, J, Rusanen, M, Hernesniemi, J et al.. Prospective Ultrasound Screening of Men With Cerebrovascular Disease for Abdominal Aortic Aneurysms. Scand J Surg. 2021;110 (3):395-399. doi: 10.1177/1457496920917269. PubMed PMID:32380927 .
  9. Lindström, I, Protto, S, Khan, N, Hernesniemi, J, Sillanpää, N, Oksala, N et al.. Association of masseter area and radiodensity with three-month survival after proximal anterior circulation occlusion. J Neurointerv Surg. 2021;13 (1):25-29. doi: 10.1136/neurintsurg-2020-015837. PubMed PMID:32303585 .

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