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Computational neuroscience

Major publications

    1. Lehtimäki, L. Paunonen and M. -L. Linne, “Accelerating Neural ODEs Using Model Order Reduction,” in IEEE Transactions on Neural Networks and Learning Systems, DOI: 10.1109/TNNLS.2022.3175757 .
    2. Manninen, A. Saudargiene, M.-L. Linne. Astrocyte-mediated spike-timing-dependent long-term depression modulates synaptic properties in the developing cortex. PLoS Computational Biology 16(11): e1008360, 2020. https://doi.org/10.1371/journal.pcbi.1008360 .
    3. Teppola, J. Acimovic, and M.-L. Linne. Unique features of networks bursts emerge from the complex interplay of the excitatory and inhibitory receptors in rat cortical neocortical networks. Frontiers in Cellular Neuroscience 13:377, 2019. https://doi.org/10.3389/fncel.2019.00377 .
    4. Manninen, R. Havela, M.-L. Linne. Computational models for calcium-mediated astrocyte functions. Frontiers in Computational Neuroscience 12:14, 2018. https://doi.org/10.3389/fncom.2018.00014 .
    5. Aćimović, T. Mäki-Marttunen, and M.-L. Linne. The role of neuroanatomy in shaping network connectivity: Analysis of a two-level statistical model. Frontiers in Neuroanatomy 9:76, 2015. https://doi.org/10.3389/fnana.2015.00076 .

 

Updated list of publications: https://orcid.org/0000-0003-2577-7329

 

2024

  1. Mäki-Marttunen, T, Blackwell, KT, Akkouh, I, Shadrin, A, Valstad, M, Elvsåshagen, T et al.. Genetic mechanisms for impaired synaptic plasticity in schizophrenia revealed by computational modeling. Proc Natl Acad Sci U S A. 2024;121 (34):e2312511121. doi: 10.1073/pnas.2312511121. PubMed PMID:39141354 PubMed Central PMC11348150.
  2. Linne, ML. Computational modeling of neuron-glia signaling interactions to unravel cellular and neural circuit functioning. Curr Opin Neurobiol. 2024;85 :102838. doi: 10.1016/j.conb.2023.102838. PubMed PMID:38310660 .
  3. Lehtimaki, M, Paunonen, L, Linne, ML. Accelerating Neural ODEs Using Model Order Reduction. IEEE Trans Neural Netw Learn Syst. 2024;35 (1):519-531. doi: 10.1109/TNNLS.2022.3175757. PubMed PMID:35617183 .

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2023

  1. Mäki-Marttunen, T, Blackwell, KT, Akkouh, I, Shadrin, A, Valstad, M, Elvsåshagen, T et al.. Genetic mechanisms for impaired synaptic plasticity in schizophrenia revealed by computational modeling. Proc Natl Acad Sci U S A. 2024;121 (34):e2312511121. doi: 10.1073/pnas.2312511121. PubMed PMID:39141354 PubMed Central PMC11348150.
  2. Linne, ML. Computational modeling of neuron-glia signaling interactions to unravel cellular and neural circuit functioning. Curr Opin Neurobiol. 2024;85 :102838. doi: 10.1016/j.conb.2023.102838. PubMed PMID:38310660 .
  3. Lehtimaki, M, Paunonen, L, Linne, ML. Accelerating Neural ODEs Using Model Order Reduction. IEEE Trans Neural Netw Learn Syst. 2024;35 (1):519-531. doi: 10.1109/TNNLS.2022.3175757. PubMed PMID:35617183 .

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2022
  1. Eriksson, O, Bhalla, US, Blackwell, KT, Crook, SM, Keller, D, Kramer, A et al.. Combining hypothesis- and data-driven neuroscience modeling in FAIR workflows. Elife. 2022;11 :. doi: 10.7554/eLife.69013. PubMed PMID:35792600 PubMed Central PMC9259018.
  2. Linne, ML, Aćimović, J, Saudargiene, A, Manninen, T. Neuron-Glia Interactions and Brain Circuits. Adv Exp Med Biol. 2022;1359 :87-103. doi: 10.1007/978-3-030-89439-9_4. PubMed PMID:35471536 .

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2022
  1. Eriksson, O, Bhalla, US, Blackwell, KT, Crook, SM, Keller, D, Kramer, A et al.. Combining hypothesis- and data-driven neuroscience modeling in FAIR workflows. Elife. 2022;11 :. doi: 10.7554/eLife.69013. PubMed PMID:35792600 PubMed Central PMC9259018.
  2. Linne, ML, Aćimović, J, Saudargiene, A, Manninen, T. Neuron-Glia Interactions and Brain Circuits. Adv Exp Med Biol. 2022;1359 :87-103. doi: 10.1007/978-3-030-89439-9_4. PubMed PMID:35471536 .

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2020
  1. Manninen, T, Saudargiene, A, Linne, ML. Astrocyte-mediated spike-timing-dependent long-term depression modulates synaptic properties in the developing cortex. PLoS Comput Biol. 2020;16 (11):e1008360. doi: 10.1371/journal.pcbi.1008360. PubMed PMID:33170856 PubMed Central PMC7654831.

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2019
  1. Teppola, H, Aćimović, J, Linne, ML. Unique Features of Network Bursts Emerge From the Complex Interplay of Excitatory and Inhibitory Receptors in Rat Neocortical Networks. Front Cell Neurosci. 2019;13 :377. doi: 10.3389/fncel.2019.00377. PubMed PMID:31555093 PubMed Central PMC6742722.
  2. Mäki-Marttunen, T, Kaufmann, T, Elvsåshagen, T, Devor, A, Djurovic, S, Westlye, LT et al.. Biophysical Psychiatry-How Computational Neuroscience Can Help to Understand the Complex Mechanisms of Mental Disorders. Front Psychiatry. 2019;10 :534. doi: 10.3389/fpsyt.2019.00534. PubMed PMID:31440172 PubMed Central PMC6691488.

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