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Computational neuroscience

Major publications

    1. H.-J. Jiang, J. Aćimović, T. Manninen, I. Ahokainen, J. Stapmanns, M. Lehtimäki, M. Diesmann, S.J. van Albada, H.E. Plesser, M.-L. Linne. Modeling neuron-astrocyte interactions in neural networks using distributed simulation. PLoS Computational Biology 21(9):e1013503, 2025. https://doi.org/10.1371/journal.pcbi.1013503

    2. M.-L. Linne. Computational modeling of neuron-glia signaling interactions to unravel cellular and neural circuit functioning. Current Opinion in Neurobiology 85:102838, 2024. https://doi.org/10.1016/j.conb.2023.102838

    3. M. Lehtimäki, L. Paunonen, M.-L. Linne. Accelerating neural ODEs using model order reduction. IEEE Transactions on Neural Networks and Learning Systems 35(1):519‒531, 2024. https://doi.org/10.1109/TNNLS.2022.3175757

    4. F. Tesler, M.-L. Linne, A. Destexhe. Modeling the relationship between neuronal activity and the BOLD signal: Contributions from astrocyte calcium dynamics. (Nature) Scientific Reports 13(1):6451, 2023. https://doi.org/10.1038/s41598-023-32618-0 .

    5. Manninen, T, Saudargiene, A, Linne, ML. Astrocyte-mediated spike-timing-dependent long-term depression modulates synaptic properties in the developing cortex. PLoS Comput Biol. 2020;16 (11):e1008360. doi: 10.1371/journal.pcbi.1008360. PubMed PMID:33170856 PubMed Central PMC7654831.

 

Updated list of publications: https://orcid.org/0000-0003-2577-7329

 

2025

  1. Kismul, JF, Ness, TV, Elvsåshagen, T, Andreassen, O, Einevoll, GT, Linne, ML et al.. Computational modelling of schizophrenia-associated alterations of ion-channel-encoding gene expression predicts a decrease in delta power. bioRxiv. 2025; :. doi: 10.1101/2025.10.20.683062. PubMed PMID:41279957 PubMed Central PMC12633257.
  2. Eissa, A, Kismul, JF, Pentz, AB, Elvsåshagen, T, Metzner, C, Akkouh, I et al.. Computational modelling of novelty detection in the mismatch negativity protocols and its impairments in schizophrenia. bioRxiv. 2025; :. doi: 10.1101/2025.09.30.679453. PubMed PMID:41256666 PubMed Central PMC12621899.
  3. Jiang, HJ, Aćimović, J, Manninen, T, Ahokainen, I, Stapmanns, J, Lehtimäki, M et al.. Modeling neuron-astrocyte interactions in neural networks using distributed simulation. PLoS Comput Biol. 2025;21 (9):e1013503. doi: 10.1371/journal.pcbi.1013503. PubMed PMID:40971948 PubMed Central PMC12494295.
  4. Mäki-Marttunen, T, Kismul, JF, Pajo, K, Schulz, JM, Manninen, T, Einevoll, GT et al.. Pre- and Post-synaptic Mechanisms of Neuronal Inhibition Assessed Through Biochemically Detailed Modeling of GABA Receptor Signaling. J Neurosci. 2025;45 (36):. doi: 10.1523/JNEUROSCI.0544-25.2025. PubMed PMID:40769724 PubMed Central PMC12410044.

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2024
  1. Mäki-Marttunen, T, Blackwell, KT, Akkouh, I, Shadrin, A, Valstad, M, Elvsåshagen, T et al.. Genetic mechanisms for impaired synaptic plasticity in schizophrenia revealed by computational modeling. Proc Natl Acad Sci U S A. 2024;121 (34):e2312511121. doi: 10.1073/pnas.2312511121. PubMed PMID:39141354 PubMed Central PMC11348150.
  2. Linne, ML. Computational modeling of neuron-glia signaling interactions to unravel cellular and neural circuit functioning. Curr Opin Neurobiol. 2024;85 :102838. doi: 10.1016/j.conb.2023.102838. PubMed PMID:38310660 .
  3. Lehtimaki, M, Paunonen, L, Linne, ML. Accelerating Neural ODEs Using Model Order Reduction. IEEE Trans Neural Netw Learn Syst. 2024;35 (1):519-531. doi: 10.1109/TNNLS.2022.3175757. PubMed PMID:35617183 .

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2022-2023
  1. Eriksson, O, Bhalla, US, Blackwell, KT, Crook, SM, Keller, D, Kramer, A et al.. Combining hypothesis- and data-driven neuroscience modeling in FAIR workflows. Elife. 2022;11 :. doi: 10.7554/eLife.69013. PubMed PMID:35792600 PubMed Central PMC9259018.
  2. Linne, ML, Aćimović, J, Saudargiene, A, Manninen, T. Neuron-Glia Interactions and Brain Circuits. Adv Exp Med Biol. 2022;1359 :87-103. doi: 10.1007/978-3-030-89439-9_4. PubMed PMID:35471536 .

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2022
  1. Eriksson, O, Bhalla, US, Blackwell, KT, Crook, SM, Keller, D, Kramer, A et al.. Combining hypothesis- and data-driven neuroscience modeling in FAIR workflows. Elife. 2022;11 :. doi: 10.7554/eLife.69013. PubMed PMID:35792600 PubMed Central PMC9259018.
  2. Linne, ML, Aćimović, J, Saudargiene, A, Manninen, T. Neuron-Glia Interactions and Brain Circuits. Adv Exp Med Biol. 2022;1359 :87-103. doi: 10.1007/978-3-030-89439-9_4. PubMed PMID:35471536 .

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2020
  1. Manninen, T, Saudargiene, A, Linne, ML. Astrocyte-mediated spike-timing-dependent long-term depression modulates synaptic properties in the developing cortex. PLoS Comput Biol. 2020;16 (11):e1008360. doi: 10.1371/journal.pcbi.1008360. PubMed PMID:33170856 PubMed Central PMC7654831.

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2019
  1. Teppola, H, Aćimović, J, Linne, ML. Unique Features of Network Bursts Emerge From the Complex Interplay of Excitatory and Inhibitory Receptors in Rat Neocortical Networks. Front Cell Neurosci. 2019;13 :377. doi: 10.3389/fncel.2019.00377. PubMed PMID:31555093 PubMed Central PMC6742722.
  2. Mäki-Marttunen, T, Kaufmann, T, Elvsåshagen, T, Devor, A, Djurovic, S, Westlye, LT et al.. Biophysical Psychiatry-How Computational Neuroscience Can Help to Understand the Complex Mechanisms of Mental Disorders. Front Psychiatry. 2019;10 :534. doi: 10.3389/fpsyt.2019.00534. PubMed PMID:31440172 PubMed Central PMC6691488.

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