Selected Publications

2020

Korhonen N, Ylitalo L, Luukkaala T, Itkonen J, Häihälä H, Jernman J, Snellman E, Palve J. Premalignant lesions, basal cell carcinoma and melanoma in patients with cutaneous squamous cell carcinoma. Arch Dermatol Res. 2020 Aug 9. doi:  10.1007/s00403-020-02114-w. Epub ahead of print. PMID: 32772261.

Korhonen N, Ylitalo L, Luukkaala T, Itkonen J, Häihälä H, Jernman J, Snellman E, Palve J. Recurrent and Metastatic Cutaneous Squamous Cell Carcinomas in a Cohort of 774 Patients in Finland. Acta Derm Venereol. 2020 Apr 21;100(8):adv00121. doi: 10.2340/00015555-3479. PMID: 32255495.

Salmivuori M, Grönroos M, Tani T, Pölönen I, Räsänen J, Annala L, Snellman E, Neittaanmäki N. Hexyl aminolevulinate, 5-aminolevulinic acid nanoemulsion and methyl aminolevulinate in photodynamic therapy of non-aggressive basal cell carcinomas: A non-sponsored, randomized, prospective and double-blinded trial. J Eur Acad Dermatol Venereol. 2020 Dec;34(12):2781-2788. doi: 10.1111/jdv.16357. Epub 2020 Jul 27. PMID: 32196772.

Srinivas N, Neittaanmäki N, Heidenreich B, Rachakonda S, Karppinen TT, Grönroos M, Tani TT, Salmivuori M, Snellman E, Hemminki K, Kumar R. TERT promoter mutations in actinic keratosis before and after treatment. Int J Cancer. 2020 May 15;146(10):2932-2934. doi: 10.1002/ijc.32878. Epub 2020 Jan 30. PMID: 31970758.

Toledo A, Karppinen T, Miettinen ME, Leppäluoto J, Vuolteenaho O, Ylianttila L, Kautiainen H, Snellman E, Partonen T. Narrow-band ultraviolet B (NB UV-B) exposures improve mood in healthy individuals differently depending on chronotype. Chronobiol Int. 2019 Nov;36(11):1570-1580. doi: 0.1080/07420528.2019.1661424. Epub 2019 Sep 6. PMID: 31530241.

Räsänen JE, Neittaanmäki N, Jeskanen L, Pölönen I, Snellman E, Grönroos M. Ablative fractional laser-assisted photodynamic therapy for lentigo maligna: a prospective pilot study. J Eur Acad Dermatol Venereol. 2020 Mar;34(3):510-517. doi: 10.1111/jdv.15925. Epub 2019 Oct 10. PMID: 31465596.

2019

Väkevä L, Niemelä S, Lauha M, Pasternack R, Hannuksela-Svahn A, Hjerppe A, Joensuu A, Soronen M, Ylianttila L, Pastila R, Kautiainen H, Snellman E, Grönroos M, Karppinen T. Narrowband ultraviolet B phototherapy improves quality of life of psoriasis and atopic dermatitis patients up to 3 months: Results from an observational multicenter study. Photodermatol Photoimmunol Photomed. 2019Sep;35(5):332-338. doi: 10.1111/phpp.12479. Epub 2019 May 20. PMID: 31063610.

Korhonen N, Ylitalo L, Luukkaala T, Itkonen J, Häihälä H, Jernman J, Snellman E, Palve J. Characteristics and Trends of Cutaneous Squamous Cell Carcinoma in a Patient Cohort in Finland 2006-2015. Acta Derm Venereol. 2019 Apr 1;99(4):412-416. doi: 10.2340/00015555-3110. PMID: 30628632.

Lagerstedt M, Huotari-Orava R, Nyberg R, Nissinen L, Farshchian M, Laasanen SL, Snellman E, Mäenpää JU, Kähäri VM. Tumor cell-specific Serpin A1 expression in vulvar squamous cell carcinoma. Arch Gynecol Obstet. 2019 May;299(5):1345-1351. doi: 10.1007/s00404-018-5015-y. Epub 2019 Jan 4. PMID: 30607583; PMCID: PMC6475512.

Toledo A, Yli-Uotila E, Kautiainen H, Pirkola S, Partonen T, Snellman E. Tanning dependence and seasonal affective disorder are frequent among sunbathers but are not associated. Psychiatry Res. 2019 Feb;272:387-391. doi: 10.1016/j.psychres.2018.12.090. Epub 2018 Dec 18. PMID: 30605797.

Nikkola V, Miettinen ME, Karisola P, Grönroos M, Ylianttila L, Alenius H, Snellman E, Partonen T. Ultraviolet B radiation modifies circadian time in epidermal skin and in subcutaneous adipose tissue. Photodermatol Photoimmunol Photomed. 2019 May;35(3):157-163. doi: 10.1111/phpp.12440. Epub 2018 Dec 10.PMID: 30472764.

Räsänen JE, Neittaanmäki N, Ylitalo L, Hagman J, Rissanen P, Ylianttila L, Salmivuori M, Snellman E, Grönroos M. 5-aminolaevulinic acid nanoemulsion is more effective than methyl-5-aminolaevulinate in daylight photodynamic therapy for actinic keratosis: a nonsponsored randomized double-blind multicentre trial. Br J Dermatol. 2019 Aug;181(2):265-274. doi: 10.1111/bjd.17311. Epub 2019 Jan 2. PMID: 30329163.

Salmivuori M, Neittaanmäki N, Pölönen I, Jeskanen L, Snellman E, Grönroos M. Hyperspectral imaging system in the delineation of Ill-defined basal cell carcinomas: a pilot study. J Eur Acad Dermatol Venereol. 2019 Jan;33(1):71-78. doi: 10.1111/jdv.15102. Epub 2018 Jun 20. PMID: 29846972.

2018

Räsänen JE, Neittaanmäki N, Ylitalo L, Hagman J, Rissanen P, Ylianttila L, Salmivuori M, Snellman E, Grönroos M.  5-aminolevulinic acid nanoemulsion (BF-200 ALA) is more effective than methyl-5-aminolevulinate (MAL) in daylight photodynamic therapy for actinic keratosis: A non-sponsored randomized double-blind multicentre trial. Br J Dermatol 2018 (accepted manuscript in press) 2018-0978.R1

Salmivuori M, Neittaanmäki N, Pölönen I, Jeskanen L, Snellman E, Grönroos M. Hyperspectral Imaging System in the Delineation of Ill-defined Basal Cell Carcinomas: A Pilot Study. J Eur Acad Dermatol Venereol. 2018 May 30. doi: 10.1111/jdv.15102. (Epub ahead of print).

Nikkola V, Grönroos M, Huotari-Orava R, Kautiainen H, Ylianttila L, Karppinen T, Partonen T, Snellman E.
Circadian Time Effects on NB-UVB-Induced Erythema in Human Skin In Vivo.
J Invest Dermatol. 2018 Feb;138(2):464-467. doi: 10.1016/j.jid.2017.08.016.

2017

Neittaanmäki N, Salmivuori M, Pölönen I, Jeskanen L, Ranki A, Saksela O, Snellman E, Grönroos M. Hyperspectral imaging in detecting dermal invasion in lentigo maligna melanoma. Br J Dermatol. 2017 Dec;177(6):1742-1744. doi: 10.1111/bjd.15267.

Karppinen T, Laine JP, Kautiainen H, Pasternack R, Reunala T, Snellman E. Empowering Heliotherapy in Psoriasis and Atopic Dermatitis: An Observational Study of 186 Subjects. Acta Derm Venereol. 2017 Feb 8;97(2):255-257. doi: 10.2340/00015555-2506.

Karppinen T, Ala-Houhala M, Ylianttila L, Kautiainen H, Lakkala K, Hannula HR, Turunen E, Viljakainen H, Reunala T, Snellman E. The effect of vernal solar UV radiation on serum 25-hydroxyvitamin D concentration depends on the baseline level: observations from a high latitude in Finland. Int J Circumpolar Health. 2017;76(1):1272790. doi: 10.1080/22423982.2016.1272790.

Neittaanmäki-Perttu N, Karppinen TT, Tani T, Snellman E, Grönroos M. Long-term Outcome of Low-concentration Hexyl-5-aminolaevulinate Daylight Photodynamic Therapy for Treatment of Actinic Keratoses. Acta Derm Venereol. 2017 Jan 4;97(1):120-121. doi: 10.2340/00015555-2484.

2016

Karppinen T, Ala-Houhala M, Ylianttila L, Kautiainen H, Viljakainen H, Reunala T, Snellman E. Narrowband Ultraviolet B Exposures Maintain Vitamin D Levels During Winter: A Randomized Controlled Trial.  Acta Derm Venereol. 2016 May;96(4):490-3. doi: 10.2340/00015555-2269.

Jussila A, Huotari-Orava R, Ylianttila L, Partonen T, Snellman E. Narrow-band ultraviolet B radiation induces the expression of β-endorphin in human skin in vivo. J Photochem Photobiol B. 2016 Feb;155:104-8. doi: 10.1016/j.jphotobiol.2016.01.007

Neittaanmäki-Perttu N, Grönroos M, Karppinen T, Snellman E, Rissanen P. Photodynamic Therapy for Actinic Keratoses: A Randomized Prospective Non-sponsored Cost-effectiveness Study of Daylight-mediated Treatment Compared with Light-emitting Diode Treatment. Acta Derm Venereol. 2016 Feb;96(2):241-4. doi: 10.2340/00015555-2205.

Neittaanmäki-Perttu N, Grönroos M, Tani T, Snellman E. Long-term Outcome of Daylight Photodynamic Therapy with Amino-5-laevulinate Nanoemulsion vs. Methyl-5-aminolaevulinate for Actinic Keratoses.Acta Derm Venereol. 2016 Jun 15;96(5):712-3. doi: 10.2340/00015555-2345.

Neittaanmäki-Perttu N, Neittaanmäki E, Pölönen I, Snellman E, Grönroos M. Safety of Novel Amino-5-laevulinate Photosensitizer Precursors in Photodynamic Therapy for Healthy Human Skin. Acta Derm Venereol. 2016 Jan;96(1):108-10. doi: 10.2340/00015555-2131.

Neittaanmäki-Perttu N, Grönroos M, Karppinen TT, Tani TT, Snellman E. Hexyl-5-aminolaevulinate 0·2% vs. methyl-5-aminolaevulinate 16% daylight photodynamic therapy for treatment of actinic keratoses: results of a randomized double-blinded pilot trial.  Br J Dermatol. 2016 Feb;174(2):427-9. doi: 10.1111/bjd.13924.

2015

Karppinen TT, Ylianttila L, Kautiainen H, Reunala T, Snellman E. Empowering heliotherapy improves clinical outcome and quality of life of psoriasis and atopic dermatitis patients. Acta Derm Venereol. 2015 May;95(5):579-82. doi: 10.2340/00015555-2028.

Neittaanmäki-Perttu N, Grönroos M, Jeskanen L, Pölönen I, Ranki A, Saksela O, Snellman E. Delineating margins of lentigo maligna using a hyperspectral imaging system. Acta Derm Venereol. 2015 May;95(5):549-52. doi: 10.2340/00015555-2010.

Lagerstedt M, Huotari-Orava R, Nyberg R, Mäenpää JU, Snellman E, Laasanen SL. Reduction in ERRα is associated with lichen sclerosus and vulvar squamous cell carcinoma.  Gynecol Oncol. 2015 Dec;139(3):536-40. doi: 10.1016/j.ygyno.2015.10.016.

Snellman E. [Atopic eczema can be treated in a pre-emptive manner]. Duodecim. 2015;131(12):1163-9. Review. Finnish.

2014

Ala-Houhala MJ, Karppinen T, Vähävihu K, Kautiainen H, Dombrowski Y, Snellman E, Schauber J, Reunala T. Narrow-band ultraviolet B treatment boosts serum 25-hydroxyvitamin D in patients with psoriasis on oral vitamin D supplementation. Acta Derm Venereol. 2014 Mar;94(2):146-51. doi: 10.2340/00015555-1685.

Neittaanmäki-Perttu N, Karppinen TT, Grönroos M, Tani TT, Snellman E. Daylight photodynamic therapy for actinic keratoses: a randomized double-blinded nonsponsored prospective study comparing 5-aminolaevulinic acid nanoemulsion (BF-200) with methyl-5-aminolaevulinate.  Br J Dermatol. 2014 Nov;171(5):1172-80. doi: 10.1111/bjd.13326

2013

Lagerstedt M, Karvinen K, Joki-Erkkilä M, Huotari-Orava R, Snellman E, Laasanen SL. Childhood lichen sclerosus–a challenge for clinicians. Pediatr Dermatol. 2013 Jul-Aug;30(4):444-50. doi: 10.1111/pde.12109.

Neittaanmäki-Perttu N, Grönroos M, Tani T, Pölönen I, Ranki A, Saksela O, Snellman E
Detecting field cancerization using a hyperspectral imaging system.
Lasers Surg Med. 2013 Sep;45(7):410-7. doi: 10.1002/lsm.22160.

Ala-Houhala MJ, Vähävihu K, Snellman E, Hasan T, Kautiainen H, Karisola P, Dombrowski Y, Schauber J, Saha H, Reunala T. A narrow-band ultraviolet B course improves vitamin D balance and alters cutaneous CYP27A1 and CYP27B1 mRNA expression levels in haemodialysis patients supplemented with oral vitamin D. Nephron Clin Pract. 2013;124(1-2):17-22. doi: 10.1159/000355010.

2012

Suttle MM, Nilsson G, Snellman E, Harvima IT. Experimentally induced psoriatic lesion associates with interleukin (IL)-6 in mast cells and appearance of dermal cells expressing IL-33 and IL-6 receptor. Clin Exp Immunol. 2012 Sep;169(3):311-9. doi: 10.1111/j.1365-2249.2012.04618.x.

Ala-Houhala MJ, Vähävihu K, Hasan T, Kautiainen H, Snellman E, Karisola P, Dombrowski Y, Schauber J, Saha H, Reunala T. Narrow-band ultraviolet B exposure increases serum vitamin D levels in haemodialysis patients. Nephrol Dial Transplant. 2012 Jun;27(6):2435-40. doi: 10.1093/ndt/gfr700

Ala-Houhala MJ, Vähävihu K, Hasan T, Kautiainen H, Ylianttila L, Viljakainen HT, Snellman E, Reunala T. Comparison of narrowband ultraviolet B exposure and oral vitamin D substitution on serum 25-hydroxyvitamin D concentration.  Br J Dermatol. 2012 Jul;167(1):160-4. doi: 10.1111/j.1365-2133.2012.10990.x.

2010

Vähävihu K, Ylianttila L, Kautiainen H, Tuohimaa P, Reunala T, Snellman E.  Spore film dosimeters are feasible for UV dose monitoring during heliotherapy. Photochem Photobiol. 2010 Sep-Oct;86(5):1174-8. doi: 10.1111/j.1751-1097.2010.00769.x.

Narrowband ultraviolet B treatment improves vitamin D balance and alters antimicrobial peptide Vähävihu K, Ala-Houhala M, Peric M, Karisola P, Kautiainen H, Hasan T, Snellman E, Alenius H, Schauber J, Reunala T.expression in skin lesions of psoriasis and atopic dermatitis.  Br J Dermatol. 2010 Aug;163(2):321-8. doi: 10.1111/j.1365-2133.2010.09767.x.

2008

Segerbäck D, Strozyk M, Snellman E, Hemminki K. Repair of UV dimers in skin DNA of patients with basal cell carcinoma. Cancer Epidemiol Biomarkers Prev ;17(9)2388-92, 2008

Vähävihu K, Ylianttila L, Salmelin R, Lamberg-Allardt C, Viljakainen H, Tuohimaa P, Reunala T, Snellman E. Heliotherapy improves vitamin D balance and atopic dermatitis. Br J Dermatol. 2008 Jun;158(6):1323-8. doi: 10.1111/j.1365-2133.2008.08518.x.

2007

Bloethner S, Snellman E, Bermejo JL, Hiripi E, Gast A, Thirumaran RK, Wellenreuther R, Hemminki K, Kumar R. Differential gene expression in melanocytic nevi with the V600E BRAF mutation. Genes Chromosomes Cancer. 2007 Nov;46(11):1019-27. PMID: 17696195

Suomela S, Kainu K, Onkamo P, Tiala I, Himberg J, Koskinen L, Snellman E, Karvonen SL, Karvonen J, Uurasmaa T, Reunala T, Kivikäs K, Jansén CT, Holopainen P, Elomaa O, Kere J, Saarialho-Kere U. Clinical associations of the risk alleles of HLA-Cw6 and CCHCR1*WWCC in psoriasis. Acta Derm Venereol. 2007;87(2):127-34. PMID: 17340018

2005

Festa F, Kumar R, Sanyal S, Undén B, Nordfors L, Lindholm B, Snellman E, Schalling M, Försti A, Hemminki K. Basal cell carcinoma and variants in genes coding for immune response, DNA repair, folate and iron metabolism. Mutat Res. 2005 Jul 1;574(1-2):105-11. Epub 2005 Mar 26. PMID: 15914210