Our research centers on the basic mechanisms of immune response using primarily non-mammalian models such as the fruit fly, Drosophila melanogaster and zebrafish Danio rerio. Our team use model organisms to investigate host-microbe interactions primarily related to globally important pathogens. In particular, we aim to find ways to combat tuberculosis. In addition, we have focused on identifying genetic alterations predisposing to the preterm birth and to the most important diseases related to prematurity (bronchopulmonary dysplasia and susceptibility to severe respiratory infections during neonatal period).
Currently, our research is funded by the Jane and Aatos Erkko Foundation, the Academy of Finland, Sigrid Juselius Foundation, Tampere Tuberculosis Foundation and Stiftelsen Alma och K. A. Snellman Foundation.
Research interests and expertise
- Spontaneous preterm delivery: susceptibility genes and timing of childbirth
- Mechanisms, prevention and treatment of the most common neonatal diseases
- Molecular mechanisms regulating innate immunity
- Development of a new vaccine against tuberculosis
- Pathophysiology of Mycobacterial infection
- Pathophysiology of Streptococcal infection