Hallman M, Haapalainen A, Huusko JM, Karjalainen MK, Zhang G, Muglia LJ, Rämet M Spontaneous premature birth as a target of genomic research. Pediatr Res ;2018
Uusi-Mäkelä M, Rämet M Hijacking Host Angiogenesis to Drive Mycobacterial Growth. Cell Host Microbe
;24(4)465-466, 2018 PMID
Pasanen A, Karjalainen MK, Kummola L, Waage J, Bønnelykke K, Ruotsalainen M, Piippo-Savolainen E, Goksör E, Nuolivirta K, Chawes B, Vissing N, Bisgaard H, Jartti T, Wennergren G, Junttila I, Hallman M, Korppi M, Rämet M NKG2D gene variation and susceptibility to viral bronchiolitis in childhood. Pediatr Res
;84(3)451-457, 2018 PMID
Khashana A, Ahmed H, Ahmed A, Abdelwahab A, Saarela T, Rämet M, Hallman M Cortisol precursors in neonates with vasopressor-resistant hypotension in relationship to demographic characteristics. J Matern Fetal Neonatal Med
;31(18)2473-2477, 2018 PMID
Valanne S, Vesala L, Rämet M Drosophila GATA Factor Serpent Establishes Phagocytic Ability of Embryonic Macrophages. Front Immunol ;2018
Harjula SE, Ojanen MJT, Taavitsainen S, Nykter M, Rämet M Interleukin 10 mutant zebrafish have an enhanced interferon gamma response and improved survival against a Mycobacterium marinum infection. Sci Rep
;8(1)10360, 2018 PMID
Uusimaa J, Kaarteenaho R, Paakkola T, Tuominen H, Karjalainen MK, Nadaf J, Varilo T, Uusi-Mäkelä M, Suo-Palosaari M, Pietilä I, Hiltunen AE, Ruddock L, Alanen H, Biterova E, Miinalainen I, Salminen A, Soininen R, Manninen A, Sormunen R, Kaakinen M, Vuolteenaho R, Herva R, Vieira P, Dunder T, Kokkonen H, Moilanen JS, Rantala H, Nogee LM, Majewski J, Rämet M, Hallman M, Hinttala R NHLRC2 variants identified in patients with fibrosis, neurodegeneration, and cerebral angiomatosis (FINCA): characterisation of a novel cerebropulmonary disease. Acta Neuropathol
;135(5)727-742, 2018 PMID
Uusi-Mäkelä MIE, Barker HR, Bäuerlein CA, Häkkinen T, Nykter M, Rämet M Chromatin accessibility is associated with CRISPR-Cas9 efficiency in the zebrafish (Danio rerio). PLoS One
;13(4)e0196238, 2018 PMID
Haapalainen AM, Karjalainen MK, Daddali R, Ohlmeier S, Anttonen J, Määttä TA, Salminen A, Mahlman M, Bergmann U, Mäkikallio K, Ojaniemi M, Hallman M, Rämet M Expression of CPPED1 in human trophoblasts is associated with timing of term birth. J Cell Mol Med
;22(2)968-981, 2018 PMID
Myllymäki H, Niskanen M, Luukinen H, Parikka M, Rämet M Identification of protective postexposure mycobacterial vaccine antigens using an immunosuppression-based reactivation model in the zebrafish. Dis Model Mech ;2018
Luukinen H, Hammarén MM, Vanha-Aho LM, Svorjova A, Kantanen L, Järvinen S, Luukinen BV, Dufour E, Rämet M, Hytönen VP, Parikka M Listeria monocytogenes induces sterilizing response in the adult zebrafish tuberculosis model. Dis Model Mech ;2018
Mahlman M, Karjalainen MK, Huusko JM, Andersson S, Kari MA, Tammela OKT, Sankilampi U, Lehtonen L, Marttila RH, Bassler D, Poets CF, Lacaze-Masmonteil T, Danan C, Delacourt C, Palotie A, Muglia LJ, Lavoie PM, Hadchouel A, Rämet M, Hallman M Genome-wide association study of bronchopulmonary dysplasia: a potential role for variants near the CRP gene. Sci Rep
;7(1)9271, 2017 PMID
Aittomäki S, Valanne S, Lehtinen T, Matikainen S, Nyman TA, Rämet M, Pesu M Drosophila fat body is essential for a normal antimicrobial peptide response and bacterial host defense. FASEB J
;31(11)4770-4782, 2017 PMID
Zhang G, Feenstra B, Bacelis J, Liu X, Muglia LM, Juodakis J, Miller DE, Litterman N, Jiang PP, Russell L, Hinds DA, Hu Y, Weirauch MT, Chen X, Chavan AR, Wagner GP, Pavličev M, Nnamani MC, Maziarz J, Karjalainen MK, Rämet M, Sengpiel V, Geller F, Boyd HA, Palotie A, Momany A, Bedell B, Ryckman KK, Huusko JM, Forney CR, Kottyan LC, Hallman M, Teramo K, Nohr EA, Davey Smith G, Melbye M, Jacobsson B, Muglia LJ Genetic Associations with Gestational Duration and Spontaneous Preterm Birth. N Engl J Med
;377(12)1156-1167, 2017 PMID
Myllymäki H, Niskanen M, Oksanen KE, Sherwood E, Ahava M, Parikka M, Rämet M Identification of novel antigen candidates for a tuberculosis vaccine in the adult zebrafish (Danio rerio). PLoS One
;12(7)e0181942, 2017 PMID
Khashana A, Saarela T, Ramet M, Hallman M Cortisol intermediates and hydrocortisone responsiveness in critical neonatal disease. J Matern Fetal Neonatal Med
;30(14)1721-1725, 2017 PMID
Pasanen A, Karjalainen MK, Bont L, Piippo-Savolainen E, Ruotsalainen M, Goksör E, Kumawat K, Hodemaekers H, Nuolivirta K, Jartti T, Wennergren G, Hallman M, Rämet M, Korppi M Genome-Wide Association Study of Polymorphisms Predisposing to Bronchiolitis. Sci Rep ;2017
Schmid MR, Anderl I, Vo HT, Valanne S, Yang H, Kronhamn J, Rämet M, Rusten TE, Hultmark D Genetic Screen in Drosophila Larvae Links ird1 Function to Toll Signaling in the Fat Body and Hemocyte Motility. PLoS One
;11(7)e0159473, 2016 PMID
Vanha-Aho LM, Valanne S, Rämet M Cytokines in Drosophila immunity. Immunol Lett ;2016
Utriainen M, Rämet M [Immuno-oncology–silver bullets or mass destruction weapons?]. Duodecim
;132(8)721-8, 2016 PMID
Salminen TS, Rämet M Pickle Flavors Relish in Drosophila Immunity. Cell Host Microbe
;20(3)273-274, 2016 PMID
Anderl I, Vesala L, Ihalainen TO, Vanha-Aho LM, Andó I, Rämet M, Hultmark D Transdifferentiation and Proliferation in Two Distinct Hemocyte Lineages in Drosophila melanogaster Larvae after Wasp Infection. PLoS Pathog
;12(7)e1005746, 2016 PMID
Myllymäki H, Bäuerlein CA, Rämet M The Zebrafish Breathes New Life into the Study of Tuberculosis. Front Immunol ;2016
Oksanen KE, Myllymäki H, Ahava MJ, Mäkinen L, Parikka M, Rämet M DNA vaccination boosts Bacillus Calmette-Guérin protection against mycobacterial infection in zebrafish. Dev Comp Immunol
;54(1)89-96, 2016 PMID
Syrjänen L, Valanne S, Kuuslahti M, Tuomela T, Sriram A, Sanz A, Jacobs HT, Rämet M, Parkkila S β carbonic anhydrase is required for female fertility in Drosophila melanogaster. Front Zool ;2015
Vanha-Aho LM, Anderl I, Vesala L, Hultmark D, Valanne S, Rämet M Edin Expression in the Fat Body Is Required in the Defense Against Parasitic Wasps in Drosophila melanogaster. PLoS Pathog
;11(5)e1004895, 2015 PMID
Karjalainen MK, Ojaniemi M, Haapalainen AM, Mahlman M, Salminen A, Huusko JM, Määttä TA, Kaukola T, Anttonen J, Ulvila J, Haataja R, Teramo K, Kingsmore SF, Palotie A, Muglia LJ, Rämet M, Hallman M CXCR3 Polymorphism and Expression Associate with Spontaneous Preterm Birth. J Immunol
;195(5)2187-98, 2015 PMID
Aspatwar A, Tolvanen ME, Ojanen MJ, Barker HR, Saralahti AK, Bäuerlein CA, Ortutay C, Pan P, Kuuslahti M, Parikka M, Rämet M, Parkkila S Inactivation of ca10a and ca10b Genes Leads to Abnormal Embryonic Development and Alters Movement Pattern in Zebrafish. PLoS One
;10(7)e0134263, 2015 PMID
Ojanen MJ, Turpeinen H, Cordova ZM, Hammarén MM, Harjula SK, Parikka M, Rämet M, Pesu M The proprotein convertase subtilisin/kexin furinA regulates zebrafish host response against Mycobacterium marinum. Infect Immun
;83(4)1431-42, 2015 PMID
Myllymäki H, Niskanen M, Oksanen KE, Rämet M Animal models in tuberculosis research – where is the beef? Expert Opin Drug Discov
;10(8)871-83, 2015 PMID
Myllymäki H, Valanne S, Rämet M The Drosophila imd signaling pathway. J Immunol
;192(8)3455-62, 2014 PMID
Saralahti A, Piippo H, Parikka M, Henriques-Normark B, Rämet M, Rounioja S Adult zebrafish model for pneumococcal pathogenesis. Dev Comp Immunol
;42(2)345-53, 2014 PMID
Schmid MR, Anderl I, Vesala L, Vanha-aho LM, Deng XJ, Rämet M, Hultmark D Control of Drosophila blood cell activation via Toll signaling in the fat body. PLoS One
;9(8)e102568, 2014 PMID
Hammarén MM, Oksanen KE, Nisula HM, Luukinen BV, Pesu M, Rämet M, Parikka M Adequate Th2-type response associates with restricted bacterial growth in latent mycobacterial infection of zebrafish. PLoS Pathog
;10(6)e1004190, 2014 PMID
Kuuluvainen E, Hakala H, Havula E, Sahal Estimé M, Rämet M, Hietakangas V, Mäkelä TP Cyclin-dependent kinase 8 module expression profiling reveals requirement of mediator subunits 12 and 13 for transcription of Serpent-dependent innate immunity genes in Drosophila. J Biol Chem
;289(23)16252-61, 2014 PMID
Rämet M, Hultmark D Drosophila immunity–glorious past, dynamic present and exciting future. Dev Comp Immunol
;42(1)1-2, 2014 PMID
Oksanen KE, Halfpenny NJ, Sherwood E, Harjula SK, Hammarén MM, Ahava MJ, Pajula ET, Lahtinen MJ, Parikka M, Rämet M An adult zebrafish model for preclinical tuberculosis vaccine development. Vaccine
;31(45)5202-9, 2013 PMID
Turpeinen H, Oksanen A, Kivinen V, Kukkurainen S, Uusimäki A, Rämet M, Parikka M, Hytönen VP, Nykter M, Pesu M Proprotein convertase subtilisin/kexin type 7 (PCSK7) is essential for the zebrafish development and bioavailability of transforming growth factor β1a (TGFβ1a). J Biol Chem
;288(51)36610-23, 2013 PMID
Valanne S, Rämet M Uracil debases pathogenic but not commensal bacteria. Cell Host Microbe
;13(5)505-6, 2013 PMID
Taskinen B, Zmurko J, Ojanen M, Kukkurainen S, Parthiban M, Määttä JA, Leppiniemi J, Jänis J, Parikka M, Turpeinen H, Rämet M, Pesu M, Johnson MS, Kulomaa MS, Airenne TT, Hytönen VP Zebavidin–an avidin-like protein from zebrafish. PLoS One
;8(10)e77207, 2013 PMID
Aspatwar A, Tolvanen ME, Jokitalo E, Parikka M, Ortutay C, Harjula SK, Rämet M, Vihinen M, Parkkila S Abnormal cerebellar development and ataxia in CARP VIII morphant zebrafish. Hum Mol Genet
;22(3)417-32, 2013 PMID
Lohi O, Parikka M, Rämet M The zebrafish as a model for paediatric diseases. Acta Paediatr
;102(2)104-10, 2013 PMID
Junttila I, Meri S, Rämet M [Inflammasome–essential regulator of the inflammatory reaction]. Duodecim
;129(7)705-11, 2013 PMID
Patterson H, Saralahti A, Parikka M, Dramsi S, Trieu-Cuot P, Poyart C, Rounioja S, Rämet M Adult zebrafish model of bacterial meningitis in Streptococcus agalactiae infection. Dev Comp Immunol
;38(3)447-55, 2012 PMID
Parikka M, Hammarén MM, Harjula SK, Halfpenny NJ, Oksanen KE, Lahtinen MJ, Pajula ET, Iivanainen A, Pesu M, Rämet M Mycobacterium marinum causes a latent infection that can be reactivated by gamma irradiation in adult zebrafish. PLoS Pathog
;8(9)e1002944, 2012 PMID
Teittinen KJ, Grönroos T, Parikka M, Rämet M, Lohi O The zebrafish as a tool in leukemia research. Leuk Res
;36(9)1082-8, 2012 PMID
Sampson CJ, Valanne S, Fauvarque MO, Hultmark D, Rämet M, Williams MJ The RhoGEF Zizimin-related acts in the Drosophila cellular immune response via the Rho GTPases Rac2 and Cdc42. Dev Comp Immunol
;38(1)160-8, 2012 PMID
Teittinen KJ, Grönroos T, Parikka M, Junttila S, Uusimäki A, Laiho A, Korkeamäki H, Kurppa K, Turpeinen H, Pesu M, Gyenesei A, Rämet M, Lohi O SAP30L (Sin3A-associated protein 30-like) is involved in regulation of cardiac development and hematopoiesis in zebrafish embryos. J Cell Biochem
;113(12)3843-52, 2012 PMID
Rämet M The fruit fly Drosophila melanogaster unfolds the secrets of innate immunity. Acta Paediatr
;101(9)900-5, 2012 PMID
Valanne S, Kallio J, Kleino A, Rämet M Large-scale RNAi screens add both clarity and complexity to Drosophila NF-κB signaling. Dev Comp Immunol
;37(1)9-18, 2012 PMID
Grönholm J, Kaustio M, Myllymäki H, Kallio J, Saarikettu J, Kronhamn J, Valanne S, Silvennoinen O, Rämet M Not4 enhances JAK/STAT pathway-dependent gene expression in Drosophila and in human cells. FASEB J
;26(3)1239-50, 2012 PMID
Rounioja S, Saralahti A, Rantala L, Parikka M, Henriques-Normark B, Silvennoinen O, Rämet M Defense of zebrafish embryos against Streptococcus pneumoniae infection is dependent on the phagocytic activity of leukocytes. Dev Comp Immunol
;36(2)342-8, 2012 PMID
Vanha-Aho LM, Kleino A, Kaustio M, Ulvila J, Wilke B, Hultmark D, Valanne S, Rämet M Functional characterization of the infection-inducible peptide Edin in Drosophila melanogaster. PLoS One
;7(5)e37153, 2012 PMID
Ulvila J, Vanha-Aho LM, Rämet M Drosophila phagocytosis – still many unknowns under the surface. APMIS
;119(10)651-62, 2011 PMID
Ulvila J, Vanha-aho LM, Kleino A, Vähä-Mäkilä M, Vuoksio M, Eskelinen S, Hultmark D, Kocks C, Hallman M, Parikka M, Rämet M Cofilin regulator 14-3-3zeta is an evolutionarily conserved protein required for phagocytosis and microbial resistance. J Leukoc Biol
;89(5)649-59, 2011 PMID
Valanne S, Rämet M [Fruit fly–genetically excellent model animal for research]. Duodecim
;127(19)2063-71, 2011 PMID
Rämet M, Korppi M, Hallman M Pattern recognition receptors and genetic risk for rsv infection: value for clinical decision-making? Pediatr Pulmonol
;46(2)101-10, 2011 PMID
Valanne S, Wang JH, Rämet M The Drosophila Toll signaling pathway. J Immunol
;186(2)649-56, 2011 PMID
Hyvärinen J, Parikka M, Sormunen R, Rämet M, Tryggvason K, Kivirikko KI, Myllyharju J, Koivunen P Deficiency of a transmembrane prolyl 4-hydroxylase in the zebrafish leads to basement membrane defects and compromised kidney function. J Biol Chem
;285(53)42023-32, 2010 PMID
Kallio J, Myllymäki H, Grönholm J, Armstrong M, Vanha-aho LM, Mäkinen L, Silvennoinen O, Valanne S, Rämet M Eye transformer is a negative regulator of Drosophila JAK/STAT signaling. FASEB J
;24(11)4467-79, 2010 PMID
Löfgren J, Marttila R, Renko M, Rämet M, Hallman M Toll-like receptor 4 Asp299Gly polymorphism in respiratory syncytial virus epidemics. Pediatr Pulmonol
;45(7)687-92, 2010 PMID
Rämet M, Hallman M Surfactant proteins and respiratory syncytial virus. J Pediatr
;157(5)866; author reply 866-7, 2010 PMID
Valanne S, Myllymäki H, Kallio J, Schmid MR, Kleino A, Murumägi A, Airaksinen L, Kotipelto T, Kaustio M, Ulvila J, Esfahani SS, Engström Y, Silvennoinen O, Hultmark D, Parikka M, Rämet M Genome-wide RNA interference in Drosophila cells identifies G protein-coupled receptor kinase 2 as a conserved regulator of NF-kappaB signaling. J Immunol
;184(11)6188-98, 2010 PMID
Wang JH, Valanne S, Rämet M Drosophila as a model for antiviral immunity. World J Biol Chem
;1(5)151-9, 2010 PMID
Grönholm J, Ungureanu D, Vanhatupa S, Rämet M, Silvennoinen O Sumoylation of Drosophila transcription factor STAT92E. J Innate Immun
;2(6)618-24, 2010 PMID
Kleino A, Myllymäki H, Kallio J, Vanha-aho LM, Oksanen K, Ulvila J, Hultmark D, Valanne S, Rämet M Pirk is a negative regulator of the Drosophila Imd pathway. J Immunol
;180(8)5413-22, 2008 PMID
Valanne S, Kleino A, Myllymäki H, Vuoristo J, Rämet M Iap2 is required for a sustained response in the Drosophila Imd pathway. Dev Comp Immunol 2007
;31(10)991-1001 PMID
Ulvila J, Parikka M, Kleino A, Sormunen R, Ezekowitz RA, Kocks C, Rämet M Double-stranded RNA is internalized by scavenger receptor-mediated endocytosis in Drosophila S2 cells. J Biol Chem 2006
;281(20)14370-5 PMID
Kocks C, Cho JH, Nehme N, Ulvila J, Pearson AM, Meister M, Strom C, Conto SL, Hetru C, Stuart LM, Stehle T, Hoffmann JA, Reichhart JM, Ferrandon D, Rämet M, Ezekowitz RA Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila. Cell 2005
;123(2)335-46 PMID
Kleino A, Valanne S, Ulvila J, Kallio J, Myllymäki H, Enwald H, Stöven S, Poidevin M, Ueda R, Hultmark D, Lemaitre B, Rämet M Inhibitor of apoptosis 2 and TAK1-binding protein are components of the Drosophila Imd pathway. EMBO J 2005
;24(19)3423-34 PMID
Kallio J, Leinonen A, Ulvila J, Valanne S, Ezekowitz RA, Rämet M Functional analysis of immune response genes in Drosophila identifies JNK pathway as a regulator of antimicrobial peptide gene expression in S2 cells. Microbes Infect 2005
;7(5-6)811-9 PMID
Rämet M [Innate immunity and infections in children]. Duodecim 2004
;120(5)553-60 PMID
Marttila R, Haataja R, Rämet M, Pokela ML, Tammela O, Hallman M Surfactant protein A gene locus and respiratory distress syndrome in Finnish premature twin pairs. Ann Med 2003
;35(5)344-52 PMID
Pearson AM, Baksa K, Rämet M, Protas M, McKee M, Brown D, Ezekowitz RA Identification of cytoskeletal regulatory proteins required for efficient phagocytosis in Drosophila. Microbes Infect 2003
;5(10)815-24 PMID
Rämet ME, Rämet M, Lu Q, Nickerson M, Savolainen MJ, Malzone A, Karas RH High-density lipoprotein increases the abundance of eNOS protein in human vascular endothelial cells by increasing its half-life. J Am Coll Cardiol 2003
;41(12)2288-97 PMID
Marttila R, Haataja R, Rämet M, Löfgren J, Hallman M Surfactant protein B polymorphism and respiratory distress syndrome in premature twins. Hum Genet 2003
;112(1)18-23 PMID
Lahti M, Lofgren J, Marttila R, Renko M, Klaavuniemi T, Haataja R, Ramet M, Hallman M Surfactant protein D gene polymorphism associated with severe respiratory syncytial virus infection. Pediatr Res 2002
;51(6)696-9 PMID
Rämet M, Manfruelli P, Pearson A, Mathey-Prevot B, Ezekowitz RA Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli. Nature 2002
;416(6881)644-8 PMID
Löfgren J, Rämet M, Renko M, Marttila R, Hallman M Association between surfactant protein A gene locus and severe respiratory syncytial virus infection in infants. J Infect Dis 2002
;185(3)283-9 PMID
Rämet M, Lanot R, Zachary D, Manfruelli P JNK signaling pathway is required for efficient wound healing in Drosophila. Dev Biol 2002
;241(1)145-56 PMID
Ramet M, Pearson A, Manfruelli P, Li X, Koziel H, Gobel V, Chung E, Krieger M, Ezekowitz RA Drosophila scavenger receptor CI is a pattern recognition receptor for bacteria. Immunity 2001
;15(6)1027-38 PMID
Haataja R, Marttila R, Uimari P, Lofgren J, Ramet M, Hallman M Respiratory distress syndrome: evaluation of genetic susceptibility and protection by transmission disequilibrium test. Hum Genet 2001
;109(3)351-5 PMID
Floros J, Fan R, Matthews A, DiAngelo S, Luo J, Nielsen H, Dunn M, Gewolb IH, Koppe J, van Sonderen L, Farri-Kostopoulos L, Tzaki M, Ramet M, Merrill J Family-based transmission disequilibrium test (TDT) and case-control association studies reveal surfactant protein A (SP-A) susceptibility alleles for respiratory distress syndrome (RDS) and possible race differences. Clin Genet 2001
;60(3)178-87 PMID
Hallman M, Ramet M, Ezekowitz RA Toll-like receptors as sensors of pathogens. Pediatr Res 2001
;50(3)315-21 PMID
Hallman M, Glumoff V, Ramet M Surfactant in respiratory distress syndrome and lung injury. Comp Biochem Physiol A Mol Integr Physiol 2001
;129(1)287-94 PMID
Ramet M, Lofgren J, Alho OP, Hallman M Surfactant protein-A gene locus associated with recurrent otitis media. J Pediatr 2001
;138(2)266-8 PMID
Bruyere K, Bermond F, Bouquet R, Caire Y, Ramet M, Voiglio E Human maxilla bone response to 30 degrees oriented impacts and comparison with frontal bone impacts. Annu Proc Assoc Adv Automot Med 2000
;44219-34 PMID
Ramet M, Haataja R, Marttila R, Hamalainen AM, Knip M, Hallman M Human surfactant protein–A gene locus for genetic studies in the Finnish population. Dis Markers 2000
;16(3-4)119-24 PMID
Haataja R, Ramet M, Marttila R, Hallman M Surfactant proteins A and B as interactive genetic determinants of neonatal respiratory distress syndrome. Hum Mol Genet 2000
;9(18)2751-60 PMID
Ramet M, Haataja R, Marttila R, Floros J, Hallman M Association between the surfactant protein A (SP-A) gene locus and respiratory-distress syndrome in the Finnish population. Am J Hum Genet 2000
;66(5)1569-79 PMID
DiAngelo S, Lin Z, Wang G, Phillips S, Ramet M, Luo J, Floros J Novel, non-radioactive, simple and multiplex PCR-cRFLP methods for genotyping human SP-A and SP-D marker alleles. Dis Markers 1999
;15(4)269-81 PMID
