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Experimental Immunology

Group leader Mika Rämet

Publications

2024

  1. Walsh, EE, Pérez Marc, G, Falsey, AR, Jiang, Q, Eiras, D, Patton, M et al.. RENOIR Trial – RSVpreF Vaccine Efficacy over Two Seasons. N Engl J Med. 2024;391 (15):1459-1460. doi: 10.1056/NEJMc2311560. PubMed PMID:39413383 .
  2. Pasanen, A, Karjalainen, MK, Korppi, M, Hallman, M, Rämet, M, Research Project FinnGen
    et al.. Genetic susceptibility to acute viral bronchiolitis. J Infect Dis. 2024; :. doi: 10.1093/infdis/jiae467. PubMed PMID:39299705 .
  3. Langley, JM, Nolan, TM, Rämet, M, Richmond, PC, Rosário Filho, N, Haazen, W et al.. A Phase 1/2a Study Evaluating Safety and Immunogenicity of Ad26.RSV.preF in RSV-seronegative Toddlers Aged 12-24 Months. Open Forum Infect Dis. 2024;11 (9):ofae453. doi: 10.1093/ofid/ofae453. PubMed PMID:39220658 PubMed Central PMC11365064.
  4. Tiensuu, H, Haapalainen, AM, Tissarinen, P, Pasanen, A, Hallman, M, Rämet, M et al.. MicroRNA expression profile in the basal plate of human placenta associates with spontaneous preterm birth. Placenta. 2024;155 :60-69. doi: 10.1016/j.placenta.2024.08.004. PubMed PMID:39137705 .
  5. Clark, R, Davies, S, Labrador, J, Loubet, P, Natalini Martínez, S, Moríñigo, HM et al.. Safety and Immunogenicity of Respiratory Syncytial Virus Prefusion F Protein Vaccine when Co-administered with Adjuvanted Seasonal Quadrivalent Influenza Vaccine in Older Adults: A Phase 3 Randomized Trial. Clin Infect Dis. 2024;79 (4):1088-1098. doi: 10.1093/cid/ciae365. PubMed PMID:39099085 PubMed Central PMC11478588.
  6. Madhi, SA, Ceballos, A, Cousin, L, Domachowske, JB, Langley, JM, Lu, E et al.. Population Attributable Risk of Wheeze in 2-<6-Year-old Children, Following a Respiratory Syncytial Virus Lower Respiratory Tract Infection in The First 2 Years of Life. Pediatr Infect Dis J. 2024; :. doi: 10.1097/INF.0000000000004447. PubMed PMID:38985986 .
  7. Goswami, J, Baqui, AH, Doreski, PA, Perez Marc, G, Jimenez, G, Ahmed, S et al.. Humoral Immunogenicity of mRNA-1345 RSV Vaccine in Older Adults. J Infect Dis. 2024;230 (5):e996-e1006. doi: 10.1093/infdis/jiae316. PubMed PMID:38889247 PubMed Central PMC11566230.
  8. Tissarinen, P, Tiensuu, H, Haapalainen, AM, Ronkainen, E, Laatio, L, Vääräsmäki, M et al.. Maternal serum alpha-1 antitrypsin levels in spontaneous preterm and term pregnancies. Sci Rep. 2024;14 (1):10819. doi: 10.1038/s41598-024-61206-z. PubMed PMID:38734716 PubMed Central PMC11088650.
  9. Curran, D, Matthews, S, Cabrera, ES, Pérez, SN, Breva, LP, Rämet, M et al.. The respiratory syncytial virus prefusion F protein vaccine attenuates the severity of respiratory syncytial virus-associated disease in breakthrough infections in adults ≥60 years of age. Influenza Other Respir Viruses. 2024;18 (2):e13236. doi: 10.1111/irv.13236. PubMed PMID:38314063 PubMed Central PMC10837780.
  10. Sáez-Llorens, X, Norero, X, Mussi-Pinhata, MM, Luciani, K, de la Cueva, IS, Díez-Domingo, J et al.. Safety and Immunogenicity of a ChAd155-Vectored Respiratory Syncytial Virus Vaccine in Infants 6-7 Months of age: A Phase 1/2 Randomized Trial. J Infect Dis. 2024;229 (1):95-107. doi: 10.1093/infdis/jiad271. PubMed PMID:37477875 PubMed Central PMC10786261.

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2023
  1. Wilson, E, Goswami, J, Baqui, AH, Doreski, PA, Perez-Marc, G, Zaman, K et al.. Efficacy and Safety of an mRNA-Based RSV PreF Vaccine in Older Adults. N Engl J Med. 2023;389 (24):2233-2244. doi: 10.1056/NEJMoa2307079. PubMed PMID:38091530 .
  2. Pasanen, A, Karjalainen, MK, FinnGen, Zhang, G, Tiensuu, H, Haapalainen, AM et al.. Meta-analysis of genome-wide association studies of gestational duration and spontaneous preterm birth identifies new maternal risk loci. PLoS Genet. 2023;19 (10):e1010982. doi: 10.1371/journal.pgen.1010982. PubMed PMID:37871108 PubMed Central PMC10621942.
  3. Muller, WJ, Madhi, SA, Seoane Nuñez, B, Baca Cots, M, Bosheva, M, Dagan, R et al.. Nirsevimab for Prevention of RSV in Term and Late-Preterm Infants. N Engl J Med. 2023;388 (16):1533-1534. doi: 10.1056/NEJMc2214773. PubMed PMID:37018470 .
  4. Walsh, EE, Pérez Marc, G, Zareba, AM, Falsey, AR, Jiang, Q, Patton, M et al.. Efficacy and Safety of a Bivalent RSV Prefusion F Vaccine in Older Adults. N Engl J Med. 2023;388 (16):1465-1477. doi: 10.1056/NEJMoa2213836. PubMed PMID:37018468 .
  5. Benfield, T, Rämet, M, Valentini, P, Seppä, I, Dagan, R, Richmond, P et al.. Safety, tolerability, and immunogenicity of V114 pneumococcal vaccine compared with PCV13 in a 2+1 regimen in healthy infants: A phase III study (PNEU-PED-EU-2). Vaccine. 2023;41 (15):2456-2465. doi: 10.1016/j.vaccine.2023.02.041. PubMed PMID:36841723 .
  6. Tissarinen, P, Tiensuu, H, Haapalainen, AM, Määttä, TA, Ojaniemi, M, Hallman, M et al.. Elevated human placental heat shock protein 5 is associated with spontaneous preterm birth. Pediatr Res. 2023;94 (2):520-529. doi: 10.1038/s41390-023-02501-9. PubMed PMID:36788289 PubMed Central PMC9926443.
  7. Saralahti, AK, Harjula, SE, Rantapero, T, Uusi-Mäkelä, MIE, Kaasinen, M, Junno, M et al.. Characterization of the innate immune response to Streptococcus pneumoniae infection in zebrafish. PLoS Genet. 2023;19 (1):e1010586. doi: 10.1371/journal.pgen.1010586. PubMed PMID:36622851 PubMed Central PMC9858863.

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2022
  1. Valanne, S, Vesala, L, Maasdorp, MK, Salminen, TS, Rämet, M. The Drosophila Toll Pathway in Innate Immunity: from the Core Pathway toward Effector Functions. J Immunol. 2022;209 (10):1817-1825. doi: 10.4049/jimmunol.2200476. PubMed PMID:36426939 .
  2. Banniettis, N, Wysocki, J, Szenborn, L, Phongsamart, W, Pitisuttithum, P, Rämet, M et al.. A phase III, multicenter, randomized, double-blind, active comparator-controlled study to evaluate the safety, tolerability, and immunogenicity of catch-up vaccination regimens of V114, a 15-valent pneumococcal conjugate vaccine, in healthy infants, children, and adolescents (PNEU-PLAN). Vaccine. 2022;40 (44):6315-6325. doi: 10.1016/j.vaccine.2022.09.003. PubMed PMID:36150974 .
  3. Tiensuu, H, Haapalainen, AM, Tissarinen, P, Pasanen, A, Määttä, TA, Huusko, JM et al.. Human placental proteomics and exon variant studies link AAT/SERPINA1 with spontaneous preterm birth. BMC Med. 2022;20 (1):141. doi: 10.1186/s12916-022-02339-8. PubMed PMID:35477570 PubMed Central PMC9047282.
  4. Knuf, M, Rämet, M, Breinholt Stærke, N, Bertrand-Gerentes, I, Thollot, Y, B’Chir, S et al.. Comparing the meningococcal serogroup C immune response elicited by a tetanus toxoid conjugate quadrivalent meningococcal vaccine (MenACYW-TT) versus a quadrivalent or monovalent C tetanus toxoid conjugate meningococcal vaccine in healthy meningococcal vaccine-naïve toddlers: A randomised, controlled trial. Hum Vaccin Immunother. 2022;18 (5):2052657. doi: 10.1080/21645515.2022.2052657. PubMed PMID:35445641 PubMed Central PMC9225511.
  5. Domachowske, J, Madhi, SA, Simões, EAF, Atanasova, V, Cabañas, F, Furuno, K et al.. Safety of Nirsevimab for RSV in Infants with Heart or Lung Disease or Prematurity. N Engl J Med. 2022;386 (9):892-894. doi: 10.1056/NEJMc2112186. PubMed PMID:35235733 .
  6. Hammitt, LL, Dagan, R, Yuan, Y, Baca Cots, M, Bosheva, M, Madhi, SA et al.. Nirsevimab for Prevention of RSV in Healthy Late-Preterm and Term Infants. N Engl J Med. 2022;386 (9):837-846. doi: 10.1056/NEJMoa2110275. PubMed PMID:35235726 .
  7. Walter, EB, Talaat, KR, Sabharwal, C, Gurtman, A, Lockhart, S, Paulsen, GC et al.. Evaluation of the BNT162b2 Covid-19 Vaccine in Children 5 to 11 Years of Age. N Engl J Med. 2022;386 (1):35-46. doi: 10.1056/NEJMoa2116298. PubMed PMID:34752019 PubMed Central PMC8609605.

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2021
  1. Järvelä-Stölting, M, Vesala, L, Maasdorp, MK, Ciantar, J, Rämet, M, Valanne, S et al.. Proteasome α6 Subunit Negatively Regulates the JAK/STAT Pathway and Blood Cell Activation in . Front Immunol. 2021;12 :729631. doi: 10.3389/fimmu.2021.729631. PubMed PMID:35003057 PubMed Central PMC8727353.
  2. Walter, EB, Talaat, KR, Sabharwal, C, Gurtman, A, Lockhart, S, Paulsen, GC et al.. Evaluation of the BNT162b2 Covid-19 Vaccine in Children 5 to 11 Years of Age. N Engl J Med. 2022;386 (1):35-46. doi: 10.1056/NEJMoa2116298. PubMed PMID:34752019 PubMed Central PMC8609605.
  3. Huusko, JM, Tiensuu, H, Haapalainen, AM, Pasanen, A, Tissarinen, P, Karjalainen, MK et al.. Integrative genetic, genomic and transcriptomic analysis of heat shock protein and nuclear hormone receptor gene associations with spontaneous preterm birth. Sci Rep. 2021;11 (1):17115. doi: 10.1038/s41598-021-96374-9. PubMed PMID:34429451 PubMed Central PMC8384995.
  4. Jacome Sanz, D, Saralahti, AK, Pekkarinen, M, Kesseli, J, Nykter, M, Rämet, M et al.. Proprotein convertase subtilisin/kexin type 9 regulates the production of acute-phase reactants from the liver. Liver Int. 2021;41 (10):2511-2522. doi: 10.1111/liv.14993. PubMed PMID:34174143 .
  5. Haapalainen, AM, Daddali, R, Hallman, M, Rämet, M. Human CPPED1 belongs to calcineurin-like metallophosphoesterase superfamily and dephosphorylates PI3K-AKT pathway component PAK4. J Cell Mol Med. 2021;25 (13):6304-17. doi: 10.1111/jcmm.16607. PubMed PMID:34009729 PubMed Central PMC8366450.
  6. Valanne, S, Järvelä-Stölting, M, Harjula, SE, Myllymäki, H, Salminen, TS, Rämet, M et al.. Correction: Osa-Containing Brahma Complex Regulates Innate Immunity and the Expression of Metabolic Genes in . J Immunol. 2021;206 (4):917-918. doi: 10.4049/jimmunol.2001320. PubMed PMID:33419771 .

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2020
  1. Saralahti, AK, Uusi-Mäkelä, MIE, Niskanen, MT, Rämet, M. Integrating fish models in tuberculosis vaccine development. Dis Model Mech. 2020;13 (8):. doi: 10.1242/dmm.045716. PubMed PMID:32859577 PubMed Central PMC7473647.
  2. Niskanen, M, Myllymäki, H, Rämet, M. DNA vaccination with the Mycobacterium marinum MMAR_4110 antigen inhibits reactivation of a latent mycobacterial infection in the adult Zebrafish. Vaccine. 2020;38 (35):5685-5694. doi: 10.1016/j.vaccine.2020.06.053. PubMed PMID:32624250 .
  3. Daddali, R, Ojaniemi, M, Hallman, M, Rämet, M, Haapalainen, AM. CPPED1-targeting microRNA-371a-5p expression in human placenta associates with spontaneous delivery. PLoS One. 2020;15 (6):e0234403. doi: 10.1371/journal.pone.0234403. PubMed PMID:32520951 PubMed Central PMC7286509.
  4. Valanne, S, Järvelä-Stölting, M, Harjula, SE, Myllymäki, H, Salminen, TS, Rämet, M et al.. Osa-Containing Brahma Complex Regulates Innate Immunity and the Expression of Metabolic Genes in . J Immunol. 2020;204 (8):2143-2155. doi: 10.4049/jimmunol.1900571. PubMed PMID:32198143 .
  5. Harjula, SE, Saralahti, AK, Ojanen, MJT, Rantapero, T, Uusi-Mäkelä, MIE, Nykter, M et al.. Characterization of immune response against Mycobacterium marinum infection in the main hematopoietic organ of adult zebrafish (Danio rerio). Dev Comp Immunol. 2020;103 :103523. doi: 10.1016/j.dci.2019.103523. PubMed PMID:31626817 .

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2019
  1. Harjula, SE, Saralahti, AK, Ojanen, MJT, Rantapero, T, Uusi-Mäkelä, MIE, Nykter, M et al.. Characterization of immune response against Mycobacterium marinum infection in the main hematopoietic organ of adult zebrafish (Danio rerio). Dev Comp Immunol. 2020;103 :103523. doi: 10.1016/j.dci.2019.103523. PubMed PMID:31626817 .
  2. Valanne, S, Salminen, TS, Järvelä-Stölting, M, Vesala, L, Rämet, M. Correction: Immune-inducible non-coding RNA molecule lincRNA-IBIN connects immunity and metabolism in Drosophila melanogaster. PLoS Pathog. 2019;15 (10):e1008088. doi: 10.1371/journal.ppat.1008088. PubMed PMID:31584999 PubMed Central PMC6777747.
  3. Tiensuu, H, Haapalainen, AM, Karjalainen, MK, Pasanen, A, Huusko, JM, Marttila, R et al.. Risk of spontaneous preterm birth and fetal growth associates with fetal SLIT2. PLoS Genet. 2019;15 (6):e1008107. doi: 10.1371/journal.pgen.1008107. PubMed PMID:31194736 PubMed Central PMC6563950.
  4. Ojanen, MJT, Uusi-Mäkelä, MIE, Harjula, SE, Saralahti, AK, Oksanen, KE, Kähkönen, N et al.. Intelectin 3 is dispensable for resistance against a mycobacterial infection in zebrafish (Danio rerio). Sci Rep. 2019;9 (1):995. doi: 10.1038/s41598-018-37678-1. PubMed PMID:30700796 PubMed Central PMC6353920.
  5. Valanne, S, Salminen, TS, Järvelä-Stölting, M, Vesala, L, Rämet, M. Immune-inducible non-coding RNA molecule lincRNA-IBIN connects immunity and metabolism in Drosophila melanogaster. PLoS Pathog. 2019;15 (1):e1007504. doi: 10.1371/journal.ppat.1007504. PubMed PMID:30633769 PubMed Central PMC6345493.
  6. Hallman, M, Haapalainen, A, Huusko, JM, Karjalainen, MK, Zhang, G, Muglia, LJ et al.. Spontaneous premature birth as a target of genomic research. Pediatr Res. 2019;85 (4):422-431. doi: 10.1038/s41390-018-0180-z. PubMed PMID:30353040 .

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