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Finnish Cardiovascular Research Center Tampere - FCRCT
FCRCT

Finnish Cardiovascular Research Center Tampere

Reijo Laaksonen

2021

  1. Hilvo, M, Jylhä, A, Lääperi, M, Jousilahti, P, Laaksonen, R. Absolute and relative risk prediction in cardiovascular primary prevention with a modified SCORE chart incorporating ceramide-phospholipid risk score and diabetes mellitus. Eur Heart J Open. 2021;1 (3):oeab010. doi: 10.1093/ehjopen/oeab010. PubMed PMID:35919880 PubMed Central PMC9242040.
  2. Bjørnestad, EØ, Dhar, I, Svingen, GFT, Pedersen, ER, Svenningsson, MM, Tell, GS et al.. Trimethyllysine predicts all-cause and cardiovascular mortality in community-dwelling adults and patients with coronary heart disease. Eur Heart J Open. 2021;1 (1):oeab007. doi: 10.1093/ehjopen/oeab007. PubMed PMID:35919088 PubMed Central PMC9242046.
  3. Mishra, PP, Mishra, BH, Lyytikäinen, LP, Hilvo, M, Juonala, M, Kähönen, M et al.. Assessment of plasma ceramides as predictor for subclinical atherosclerosis. Atheroscler Plus. 2021;45 :25-31. doi: 10.1016/j.athplu.2021.09.005. PubMed PMID:36643994 PubMed Central PMC9833256.
  4. Lindqvist, HM, Bärebring, L, Gjertsson, I, Jylhä, A, Laaksonen, R, Winkvist, A et al.. A Randomized Controlled Dietary Intervention Improved the Serum Lipid Signature towards a Less Atherogenic Profile in Patients with Rheumatoid Arthritis. Metabolites. 2021;11 (9):. doi: 10.3390/metabo11090632. PubMed PMID:34564448 PubMed Central PMC8472309.
  5. Signori, C, Meessen, JMTA, Laaksonen, R, Maggioni, AP, Novelli, D, Blanda, A et al.. Coffee, Atrial Fibrillation, and Circulating Ceramides in Patients with Chronic Heart Failure. J Agric Food Chem. 2021;69 (38):11236-11245. doi: 10.1021/acs.jafc.1c03741. PubMed PMID:34533314 .
  6. Leiherer, A, Mündlein, A, Brandtner, EM, Säly, CH, Ramadani, H, Vonbank, A et al.. Lipid profiles of patients with manifest coronary versus peripheral atherosclerosis – Is there a difference?. J Intern Med. 2021;290 (6):1249-1263. doi: 10.1111/joim.13368. PubMed PMID:34337800 .
  7. Mishra, BH, Mishra, PP, Mononen, N, Hilvo, M, Sievänen, H, Juonala, M et al.. Uncovering the shared lipidomic markers of subclinical osteoporosis-atherosclerosis comorbidity: The Young Finns Study. Bone. 2021;151 :116030. doi: 10.1016/j.bone.2021.116030. PubMed PMID:34098163 .
  8. Liuska, PJ, Lemmelä, S, Havulinna, AS, Kaarniranta, K, Uusitalo, H, Laivuori, H et al.. Association of the MYOC p.(Gln368Ter) Variant With Glaucoma in a Finnish Population. JAMA Ophthalmol. 2021;139 (7):762-768. doi: 10.1001/jamaophthalmol.2021.1610. PubMed PMID:34081096 PubMed Central PMC8176385.
  9. Weichwald, S, Candreva, A, Burkholz, R, Klingenberg, R, Räber, L, Heg, D et al.. Improving 1-year mortality prediction in ACS patients using machine learning. Eur Heart J Acute Cardiovasc Care. 2021;10 (8):855-865. doi: 10.1093/ehjacc/zuab030. PubMed PMID:34015112 PubMed Central PMC8557454.
  10. Natarajan, P, Pampana, A, Graham, SE, Ruotsalainen, SE, Perry, JA, de Vries, PS et al.. Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices. Nat Commun. 2021;12 (1):2182. doi: 10.1038/s41467-021-22339-1. PubMed PMID:33846329 PubMed Central PMC8042019.
  11. Gharahkhani, P, Jorgenson, E, Hysi, P, Khawaja, AP, Pendergrass, S, Han, X et al.. Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries. Nat Commun. 2021;12 (1):1258. doi: 10.1038/s41467-020-20851-4. PubMed PMID:33627673 PubMed Central PMC7904932.
  12. Strausz, S, Kiiskinen, T, Broberg, M, Ruotsalainen, S, Koskela, J, Bachour, A et al.. Sleep apnoea is a risk factor for severe COVID-19. BMJ Open Respir Res. 2021;8 (1):. doi: 10.1136/bmjresp-2020-000845. PubMed PMID:33436406 PubMed Central PMC7804843.
  13. Ruotsalainen, SE, Partanen, JJ, Cichonska, A, Lin, J, Benner, C, Surakka, I et al.. An expanded analysis framework for multivariate GWAS connects inflammatory biomarkers to functional variants and disease. Eur J Hum Genet. 2021;29 (2):309-324. doi: 10.1038/s41431-020-00730-8. PubMed PMID:33110245 PubMed Central PMC7868371.

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2020

  1. Hilvo, M, Vasile, VC, Donato, LJ, Hurme, R, Laaksonen, R. Ceramides and Ceramide Scores: Clinical Applications for Cardiometabolic Risk Stratification. Front Endocrinol (Lausanne). 2020;11 :570628. doi: 10.3389/fendo.2020.570628. PubMed PMID:33133018 PubMed Central PMC7550651.
  2. Yüzbaşıoğulları, AB, Kömürcü-Bayrak, E, Onat, A, Can, G, Mononen, N, Laaksonen, R et al.. Sex-specific associations of TCF7L2 variants with fasting glucose, type 2 diabetes and coronary heart disease among Turkish adults. Anatol J Cardiol. 2020;24 (5):326-333. doi: 10.14744/AnatolJCardiol.2020.57736. PubMed PMID:33122478 PubMed Central PMC7724383.
  3. Ruotsalainen, SE, Partanen, JJ, Cichonska, A, Lin, J, Benner, C, Surakka, I et al.. An expanded analysis framework for multivariate GWAS connects inflammatory biomarkers to functional variants and disease. Eur J Hum Genet. 2021;29 (2):309-324. doi: 10.1038/s41431-020-00730-8. PubMed PMID:33110245 PubMed Central PMC7868371.
  4. Meeusen, JW, Donato, LJ, Kopecky, SL, Vasile, VC, Jaffe, AS, Laaksonen, R et al.. Ceramides improve atherosclerotic cardiovascular disease risk assessment beyond standard risk factors. Clin Chim Acta. 2020;511 :138-142. doi: 10.1016/j.cca.2020.10.005. PubMed PMID:33058843 .
  5. Bao, EL, Nandakumar, SK, Liao, X, Bick, AG, Karjalainen, J, Tabaka, M et al.. Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells. Nature. 2020;586 (7831):769-775. doi: 10.1038/s41586-020-2786-7. PubMed PMID:33057200 PubMed Central PMC7606745.
  6. Zelnik, ID, Volpert, G, Viiri, LE, Kauhanen, D, Arazi, T, Aalto-Setälä, K et al.. Different rates of flux through the biosynthetic pathway for long-chain versus very-long-chain sphingolipids. J Lipid Res. 2020;61 (10):1341-1346. doi: 10.1194/jlr.RA120000984. PubMed PMID:32651186 PubMed Central PMC7529049.
  7. Hilvo, M, Wallentin, L, Ghukasyan Lakic, T, Held, C, Kauhanen, D, Jylhä, A et al.. Prediction of Residual Risk by Ceramide-Phospholipid Score in Patients With Stable Coronary Heart Disease on Optimal Medical Therapy. J Am Heart Assoc. 2020;9 (10):e015258. doi: 10.1161/JAHA.119.015258. PubMed PMID:32375553 PubMed Central PMC7660846.
  8. Mars, N, Koskela, JT, Ripatti, P, Kiiskinen, TTJ, Havulinna, AS, Lindbohm, JV et al.. Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers. Nat Med. 2020;26 (4):549-557. doi: 10.1038/s41591-020-0800-0. PubMed PMID:32273609 .
  9. Mishra, BH, Mishra, PP, Mononen, N, Hilvo, M, Sievänen, H, Juonala, M et al.. Lipidomic architecture shared by subclinical markers of osteoporosis and atherosclerosis: The Cardiovascular Risk in Young Finns Study. Bone. 2020;131 :115160. doi: 10.1016/j.bone.2019.115160. PubMed PMID:31759205 .
  10. Busnelli, M, Manzini, S, Bonacina, F, Soldati, S, Barbieri, SS, Amadio, P et al.. Fenretinide treatment accelerates atherosclerosis development in apoE-deficient mice in spite of beneficial metabolic effects. Br J Pharmacol. 2020;177 (2):328-345. doi: 10.1111/bph.14869. PubMed PMID:31621898 PubMed Central PMC6989955.
  11. Hilvo, M, Meikle, PJ, Pedersen, ER, Tell, GS, Dhar, I, Brenner, H et al.. Development and validation of a ceramide- and phospholipid-based cardiovascular risk estimation score for coronary artery disease patients. Eur Heart J. 2020;41 (3):371-380. doi: 10.1093/eurheartj/ehz387. PubMed PMID:31209498 .

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