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Finnish Cardiovascular Research Center Tampere - FCRCT
FCRCT

Finnish Cardiovascular Research Center Tampere

Selected publications

  1. Hernesniemi JA, Lyytikainen L-P, Oksala N, Seppala I, Kleber ME, Mononen N, Marz W, Mikkelsson J, Pessi T, Louhelainen A-M, Martiskainen M, Nikus K, Klopp N, Waldenberger M, Illig T, Kahonen M, Laaksonen R, Karhunen PJ, Lehtimaki T. Predicting sudden cardiac death using common genetic risk variants for coronary artery disease. Eur Heart J. 2015;36:1669–1675.
  2. Karjalainen JP, Mononen N, Hutri-Kähönen N, Lehtimäki M, Hilvo M, Kauhanen D, Juonala M, Viikari J, Kähönen M, Raitakari O, Laaksonen R, Lehtimäki T. (2019), New evidence from plasma ceramides links apoE polymorphism to greater risk of coronary artery disease in Finnish adults. J Lipid Res. Sep;60(9):1622-1629. doi: 10.1194/jlr.M092809
  3. Mishra BH, Mishra PP, Mononen N, Hilvo M, Sievänen H, Juonala M, Laaksonen M, Hutri-Kähönen N, Viikari J, Kähönen M, Raitakari OT, Laaksonen R, Lehtimäki T. (2020), Lipidomic architecture shared by subclinical markers of osteoporosis and atherosclerosis: The Cardiovascular Risk in Young Finns Study. Bone. Feb;131:115160. doi: 10.1016/j.bone.2019.115160
  4. Sipilä K, Tikkakoski A, Alanko S, Haarala A, Hernesniemi J, Lyytikäinen LP, Viik J, Lehtimäki T, Nieminen T, Nikus K, Kähönen M. Combination of low blood pressure response, low exercise capacity and slow heart rate recovery during an exercise test significantly increases mortality risk. Ann Med. 2019 Nov – Dec;51(7-8):390-396. doi: 10.1080/07853890.2019.1684550.
  5. Hernesniemi JA, Sipilä K, Tikkakoski A, Tynkkynen JT, Mishra PP, Lyytikäinen LP, Nikus K, Nieminen T, Lehtimaki T, Kähönen M. Cardiorespiratory fitness and heart rate recovery predict sudden cardiac death independent of ejection fraction. Heart. 2020 Mar;106(6):434-440. doi: 10.1136/heartjnl-2019-315198.
  6. Sipilä K, Tuominen H, Haarala A, Tikkakoski A, Kähönen M, Nikus K. Novel ECG parameters are strongly associated with inflammatory 18F-FDG PET findings in patients with suspected cardiac sarcoidosis. Int J Cardiol. 2017 Dec 15;249:454-460. doi: 10.1016/j.ijcard.2017.07.027
  7. Kiviaho AL., Ahola, A., Larsson, K., Kujala K., Pekkanen-Mattila, M., Venäläinen, H., Paavola, K., Hyttinen J. and Aalto-Setälä, K. Distinct electrophysiological and mechanical beating phenotypes of Long QT syndrome type 1 -specific cardiomyocytes carrying different mutations. International Journal of Cardiology, 8:19-31, 2015
  8. Penttinen, K , Swan H, Vanninen, S, Paavola J, Lahtinen A.M., Kontula, K and Aalto-Setälä K. Demonstration of the Antiarrhythmic Effect of Dantrolene in a Subset of CPVT Patients That is Predicted in iPSC Model PLoS One, Aug 26;10(8):e0135806. doi: 10.1371/journal.pone.0135806. eCollection 2015
  9. Juhola M, Joutsijoki H, Penttinen Kirsi, Aalto-Setälä K. Detection of genetic cardiac diseases by Ca2+ transient profiles using machine learning methods Sci Rep. 2018 Jun 19;8(1):9355. doi: 10.1038/s41598-018-27695-5.
  10. Paci M, Casini S, Bellin M, Hyttinen J, Severi S. (2018), Large-Scale Simulation of the Phenotypical Variability Induced by Loss-of-Function Long QT Mutations in Human Induced Pluripotent Stem Cell Cardiomyocytes. Int J Mol Sci. 2018 Nov 13;19(11). pii: E3583. doi: 10.3390/ijms19113583.
  11. Paci M, Pölönen RP, Cori D, Penttinen K, Aalto-Setälä K, Severi S, Hyttinen J.(2018), Automatic Optimization of an in Silico Model of Human iPSC Derived Cardiomyocytes Recapitulating Calcium Handling Abnormalities. Front Physiol. 2018 Jun 26;9:709. doi: 10.3389/fphys.2018.00709.
  12. Paci M, Passini E, Severi S, Hyttinen J, Rodriguez B. (2017), Phenotypic variability in LQT3 human induced pluripotent stem cell-derived cardiomyocytes and their response to antiarrhythmic pharmacologic therapy: An in silico approach. Heart Rhythm. 2017 Nov;14(11):1704-1712. doi: 10.1016/j.hrthm.2017.07.026.
  13. Peltokangas M, Suominen V, Vakhitov D, Verho J, Korhonen J, Lekkala J, Vehkaoja A, Oksala N. (2018) “The effect of percutaneous transluminal angioplasty of superficial femoral artery on pulse wave features”. Computers in Biology and Medicine. vol. 96, pp. 274-282. DOI: 10.1016/j.compbiomed.2018.04.003
  14. Peltokangas M, Suominen V, Vakhitov D, Korhonen J, Verho J, Mattila V M, Romsi P, Lekkala J, Vehkaoja A, Oksala N, (2018) “Effects of percutaneous transluminal angioplasty of superficial femoral artery on photoplethysmographic pulse transit times, IEEE Journal of Biomedical and Health Informatics, 23(3), 1058-1065. DOI: 10.1109/JBHI.2018.2851388
  15. Christoph Hoog Antink, Yen Mai, Roosa Aalto, Christoph Bruser, Steffen Leonhardt, Niku Oksala, and Antti Vehkaoja. (2020) “Ballistocardiography can Estimate Beat-to-Beat Heart Rate Accurately at Night in Patients after Vascular Intervention”, IEEE Journal of Biomedical and Health Informatics, accepted 31.1.2020. DOI: 10.1109/JBHI.2020.2970298
  16. Peltokangas M, Huotari M, Suominen V, Vakhitov D, Korhonen J, Verho J, Röning J, Mattila V M, Romsi P, Oksala N, Vehkaoja A, (2019) “Lower limb pulse rise time as a marker of peripheral arterial disease”, IEEE Transactions on Biomedical Engineering, 66(9), pp. 2596-2603. DOI: 10.1109/TBME.2019.2892407
  17. Patrakka O, Pienimäki JP, Tuomisto S, Ollikainen J, Lehtimäki T, Karhunen PJ, Martiskainen M. Oral Bacterial Signatures in Cerebral Thrombi of Patients With Acute Ischemic Stroke Treated With Thrombectomy. J Am Heart Assoc. 2019 Jun 4;8(11) :e012330. doi: 10.1161/JAHA.119.012330.
  18. Hernesniemi JA, Mahdinani S, Tynkkynen J, Lyytikäinen L-P, Mishra P, Lehtimäki T, Eskola M, Nikus K, Antila K, Oksala N. Extensive phenotype data and machine learning in prediction of mortality in acute coronary syndrome – The MADDEC Study. Ann Med 2019;51:156–163.
  19. Hernesniemi JA, Heiskanen J, Ruohonen S, Kartiosuo N, Hutri-Kahonen N, Kahonen M, Jokinen E, Tossavainen P, Kallio M, Laitinen T, Lehtimaki T, Viikari JSA, Juonala M, Raitakari OT. Aortic sinus diameter in middle age is associated with body size in young adulthood. Heart. 2018;104:773–778.
  20. Juho Tynkkynen , Vincent Chouraki, Sven J van der Lee, Jussi Hernesniemi, Qiong Yang, Shuo Li, Alexa Beiser, Martin G Larson, Katri Sääksjärvi, Martin J Shipley, Archana Singh-Manoux, Robert E Gerszten, Thomas J Wang, Aki S Havulinna, Peter Würtz, Krista Fischer, Ayse Demirkan, M Arfan Ikram, Najaf Amin, Terho Lehtimäki, Mika Kähönen, Markus Perola, Andres Metspalu, Antti J Kangas, Pasi Soininen, Mika Ala-Korpela, Ramachandran S Vasan, Mika Kivimäki, Cornelia M van Duijn, Sudha Seshadri, Veikko Salomaa. Association of Branched-Chain Amino Acids and Other Circulating Metabolites With Risk of Incident Dementia and Alzheimer’s Disease: A Prospective Study in Eight Cohorts. Alzheimers Dement. 2018 Jun;14(6):723-733. doi: 10.1016/j.jalz.2018.01.003. Epub 2018 Mar 6.
  21. Honkonen M, Vääräniemi K, Saijonmaa O, Nyman A, Tikkakoski A, Koskela J, Lehtimäki T, Kähönen M, Mustonen J, Fyhrquist F, Pörsti I: Leukocyte telomere length is inversely associated with arterial wave reflection in 566 normotensive and never-treated hypertensive subjects. Aging 2020, doi.org/10.1111/joim.13115.
  22. Kangas P, Tahvanainen A, Tikkakoski A, Koskela J, Uitto M, Viik J, Kähönen M, Kööbi T, Mustonen J, Pörsti I. Increased Cardiac Workload in the Upright Posture in Male Subjects: Non-Invasive Hemodynamics in Men versus Women. (2016), J Am Heart Assoc. 2016 Jun 21;5(6). pii: e002883. doi: 10.1161/JAHA.115.002883.
  23. Tahvanainen AM, Tikkakoski AJ, Koskela JK, Nordhausen K, Viitala JM, Leskinen MH, Kähönen MA, Kööbi T, Uitto MT, Viik J, Mustonen JT, Pörsti IH (2016), The type of the functional cardiovascular response to upright posture is associated with arterial stiffness: a cross-sectional study in 470 volunteers. BMC Cardiovasc Disord. 2016 May 23;16:101. doi: 10.1186/s12872-016-0281-8.
  24. Wilenius M, Tikkakoski AJ, Tahvanainen AM, Haring A, Koskela J, Huhtala H, Kähönen M, Kööbi T, Mustonen JT, Pörsti IH. (2016), Central wave reflection is associated with peripheral arterial resistance in addition to arterial stiffness in subjects without antihypertensive medication. BMC Cardiovasc Disord. 2016 Jun 7;16:131. doi: 10.1186/s12872-016-0303-6.
  25. Choudhary MK, Eräranta A, Bouquin H, Tikkakoski A, Kähönen M, Sipilä K, Mustonen J, Pörsti I: Effect of present versus previous smoking on non-invasive hemodynamic. Scientific Reports, 2018, 8:13643. doi:10.1038/s41598-018-31904-6.
  26. Choudhary MK, Värri E, Matikainen N, Koskela J, Tikkakoski AJ, Kähönen M, Niemelä O, Mustonen J, Nevalainen PI, Pörsti I: Primary aldosteronism: higher volume load, cardiac output and arterial stiffness than in essential hypertension. Journal of Internal Medicine 2020, doi: 10.1038/s41371-019-0188-9.
  27. Havulinna AS, Sysi-Aho M, Hilvo M, Kauhanen D, Hurme R, Ekroos K, Salomaa V, Laaksonen R. Circulating Ceramides Predict Cardiovascular Outcomes in the Population-Based FINRISK 2002 Cohort. Arterioscler Thromb Vasc Biol. 2016 Dec;36(12):2424-2430.
  28. Laaksonen R, Ekroos K, Sysi-Aho M, Hilvo M, Vihervaara T, Kauhanen D, Suoniemi M, Hurme R, März W, Scharnagl H, Stojakovic T, Vlachopoulou E, Lokki ML, Nieminen MS, Klingenberg R, Matter CM, Hornemann T, Jüni P, Rodondi N, Räber L, Windecker S, Gencer B, Pedersen ER, Tell GS, Nygård O, Mach F, Sinisalo J, Lüscher TF. Plasma ceramides predict cardiovascular death in patients with stable coronary artery disease and acute coronary syndromes beyond LDL-cholesterol. Eur Heart J. 2016 Jul 1;37(25):1967-76.
  29. Hilvo M, Meikle PJ, Pedersen ER, Tell GS, Dhar I, Brenner H, Schöttker B, Lääperi M, Kauhanen D, Koistinen KM, Jylhä A, Huynh K, Mellett NA, Tonkin AM, Sullivan DR, Simes J, Nestel P, Koenig W, Rothenbacher D, Nygård O, Laaksonen R. (2019), Development and validation of a ceramide- and phospholipid-based cardiovascular risk estimation score for coronary artery disease patients. Eur Heart J. 2020 Jan 14;41(3):371-380. doi: 10.1093/eurheartj/ehz387.
  30. Mika Hilvo, Lars Wallentin, Tatevik Ghukasyan Lakic, Claes Held, Dimple Kauhanen, Antti Jylhä, Johan Lindbäck, Agneta Siegbahn, Christopher B Granger, Wolfgang Koenig, Ralph A H Stewart, Harvey White, Reijo Laaksonen. Prediction of residual risk by ceramide-phospholipid score in patients with stable coronary heart disease on optimal medical therapy. J Am Heart Assoc. 2020 May 18;9(10):e015258. doi: 10.1161/JAHA.119.015258.