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Obstetrics and Clinical Genetics

Publications

2024

  1. Tieu, S, Koivusalo, S, Lahti, J, Engberg, E, Laivuori, H, Huvinen, E et al.. Genetic risk of type 2 diabetes modifies the association between lifestyle and glycemic health at 5 years postpartum among high-risk women. BMJ Open Diabetes Res Care. 2024;12 (2):. doi: 10.1136/bmjdrc-2023-003942. PubMed PMID:38631819 .
  2. Kariniemi, K, Vääräsmäki, M, Männistö, T, Mustaniemi, S, Kajantie, E, Eteläinen, S et al.. Neonatal outcomes according to different glucose threshold values in gestational diabetes: a register-based study. BMC Pregnancy Childbirth. 2024;24 (1):271. doi: 10.1186/s12884-024-06473-4. PubMed PMID:38609891 PubMed Central PMC11010296.
  3. Richardt, A, Aarnio, K, Korhonen, A, Rantanen, K, Verho, L, Curtze, S et al.. Acute recanalization therapy for ischemic stroke during pregnancy and puerperium. J Neurol. 2024; :. doi: 10.1007/s00415-024-12313-4. PubMed PMID:38568226 .
  4. Venkatesh, SS, Wittemans, LBL, Palmer, DS, Baya, NA, Ferreira, T, Hill, B et al.. Genome-wide analyses identify 21 infertility loci and over 400 reproductive hormone loci across the allele frequency spectrum. medRxiv. 2024; :. doi: 10.1101/2024.03.19.24304530. PubMed PMID:38562841 PubMed Central PMC10984039.
  5. Montgomery-Csobán, T, Kavanagh, K, Murray, P, Robertson, C, Barry, SJE, Vivian Ukah, U et al.. Machine learning-enabled maternal risk assessment for women with pre-eclampsia (the PIERS-ML model): a modelling study. Lancet Digit Health. 2024;6 (4):e238-e250. doi: 10.1016/S2589-7500(23)00267-4. PubMed PMID:38519152 PubMed Central PMC10983826.
  6. Kerola, AM, Palomäki, A, Laivuori, H, Laitinen, T, Färkkilä, M, Eklund, KK et al.. Patterns of reproductive health in inflammatory rheumatic diseases and other immune-mediated diseases: a nationwide registry study. Rheumatology (Oxford). 2024; :. doi: 10.1093/rheumatology/keae122. PubMed PMID:38503536 .
  7. de Ruyter, H, Aitokari, L, Lahti, S, Riekki, H, Huhtala, H, Lakka, T et al.. Maternal gestational hypertension, smoking and pre-eclampsia are associated with metabolic dysfunction-associated fatty liver disease in overweight offspring. Acta Obstet Gynecol Scand. 2024; :. doi: 10.1111/aogs.14816. PubMed PMID:38433535 .
  8. Mars, N, Kerminen, S, Tamlander, M, Pirinen, M, Jakkula, E, Aaltonen, K et al.. Comprehensive Inherited Risk Estimation for Risk-Based Breast Cancer Screening in Women. J Clin Oncol. 2024; :JCO2300295. doi: 10.1200/JCO.23.00295. PubMed PMID:38422475 .
  9. Burns, K, Mullin, BH, Moolhuijsen, LME, Laisk, T, Tyrmi, JS, Cui, J et al.. Body mass index stratified meta-analysis of genome-wide association studies of polycystic ovary syndrome in women of European ancestry. BMC Genomics. 2024;25 (1):208. doi: 10.1186/s12864-024-09990-w. PubMed PMID:38408933 PubMed Central PMC10895801.
  10. Girchenko, P, Lahti-Pulkkinen, M, Hämäläinen, E, Laivuori, H, Villa, PM, Kajantie, E et al.. Associations of polymetabolic risk of high maternal pre-pregnancy body mass index with pregnancy complications, birth outcomes, and early childhood neurodevelopment: findings from two pregnancy cohorts. BMC Pregnancy Childbirth. 2024;24 (1):78. doi: 10.1186/s12884-024-06274-9. PubMed PMID:38267899 PubMed Central PMC10807109.
  11. Youssef, O, Loukola, A, Zidi-Mouaffak, YHS, Tamlander, M, Ruotsalainen, S, Kilpeläinen, E et al.. High-Resolution Genotyping of Formalin-Fixed Tissue Accurately Estimates Polygenic Risk Scores in Human Diseases. Lab Invest. 2024;104 (4):100325. doi: 10.1016/j.labinv.2024.100325. PubMed PMID:38220043 .
  12. Nurkkala, JM, Aittokallio, J, FinnGen
    , Kauko, A, Niiranen, T. Sex-specific genetic risks for adverse outcomes after coronary revascularization procedures. Interdiscip Cardiovasc Thorac Surg. 2024;38 (1):. doi: 10.1093/icvts/ivae006. PubMed PMID:38216540 PubMed Central PMC10799751.
  13. Toivonen, E, Taurio, K, Kortelainen, E, Havulinna, AS, FINNPEC, Jääskeläinen, T et al.. Validation of the Finnish Care register for Health Care diagnoses for preeclampsia, gestational diabetes and preterm delivery. Pregnancy Hypertens. 2024;35 :26-29. doi: 10.1016/j.preghy.2023.12.001. PubMed PMID:38091805 .
  14. Magnusson, Å, Hanevik, HI, Laivuori, H, Loft, A, Piltonen, T, Pinborg, A et al.. Endometrial preparation protocols prior to frozen embryo transfer – convenience or safety?. Reprod Biomed Online. 2024;48 (1):103587. doi: 10.1016/j.rbmo.2023.103587. PubMed PMID:37949762 .
  15. Renlund, M, Tulppo, MP, Kivelä, A, Laivuori, H, Heinonen, S, Jääskeläinen, T et al.. Preeclampsia-exposed children’s heart rate variability 8-12 yr after index pregnancy: FINNCARE study. Am J Physiol Heart Circ Physiol. 2024;326 (1):H74-H81. doi: 10.1152/ajpheart.00540.2023. PubMed PMID:37921662 .
  16. Vest, T, Rantanen, K, Verho, L, Aarnio, K, Korhonen, A, Richardt, A et al.. Etiology of intracerebral hemorrhage during pregnancy or puerperium: A nationwide study. Eur J Neurol. 2024;31 (3):e16012. doi: 10.1111/ene.16012. PubMed PMID:37532682 .

Search PubMed

2023

  1. Toivonen, E, Taurio, K, Kortelainen, E, Havulinna, AS, FINNPEC, Jääskeläinen, T et al.. Validation of the Finnish Care register for Health Care diagnoses for preeclampsia, gestational diabetes and preterm delivery. Pregnancy Hypertens. 2024;35 :26-29. doi: 10.1016/j.preghy.2023.12.001. PubMed PMID:38091805 .
  2. Lankinen, V, Vuorinen, RL, Helminen, M, Bakti, K, Välipakka, J, Laivuori, H et al.. Costs of abduction treatment in developmental dysplasia of the hip. Analysis of 900 patients. Ann Med. 2023;55 (2):2290694. doi: 10.1080/07853890.2023.2290694. PubMed PMID:38065688 PubMed Central PMC10836239.
  3. Nurmi, AK, Pelttari, LM, Kiiski, JI, Khan, S, Nurmikolu, M, Suvanto, M et al.. NTHL1 is a recessive cancer susceptibility gene. Sci Rep. 2023;13 (1):21127. doi: 10.1038/s41598-023-47441-w. PubMed PMID:38036545 PubMed Central PMC10689455.
  4. Magnusson, Å, Hanevik, HI, Laivuori, H, Loft, A, Piltonen, T, Pinborg, A et al.. Endometrial preparation protocols prior to frozen embryo transfer – convenience or safety?. Reprod Biomed Online. 2024;48 (1):103587. doi: 10.1016/j.rbmo.2023.103587. PubMed PMID:37949762 .
  5. Renlund, M, Tulppo, MP, Kivelä, A, Laivuori, H, Heinonen, S, Jääskeläinen, T et al.. Preeclampsia-exposed children’s heart rate variability 8-12 yr after index pregnancy: FINNCARE study. Am J Physiol Heart Circ Physiol. 2024;326 (1):H74-H81. doi: 10.1152/ajpheart.00540.2023. PubMed PMID:37921662 .
  6. Pasanen, A, Karjalainen, MK, FinnGen, Zhang, G, Tiensuu, H, Haapalainen, AM et al.. Meta-analysis of genome-wide association studies of gestational duration and spontaneous preterm birth identifies new maternal risk loci. PLoS Genet. 2023;19 (10):e1010982. doi: 10.1371/journal.pgen.1010982. PubMed PMID:37871108 PubMed Central PMC10621942.
  7. Renlund, M, Jääskeläinen, T, Kivelä, A, Heinonen, S, Laivuori, H, Sarkola, T et al.. Determinants of vascular structure and function in at-risk children born to mothers managed for pre-eclampsia (FINNCARE study). Front Cardiovasc Med. 2023;10 :1264921. doi: 10.3389/fcvm.2023.1264921. PubMed PMID:37859683 PubMed Central PMC10582712.
  8. Lähdepuro, A, Lahti-Pulkkinen, M, Girchenko, P, Villa, PM, Heinonen, K, Lahti, J et al.. Positive maternal mental health during pregnancy and psychiatric problems in children from early childhood to late childhood. Dev Psychopathol. 2023; :1-13. doi: 10.1017/S0954579423001244. PubMed PMID:37814418 .
  9. Kinnunen, J, Nikkinen, H, Keikkala, E, Mustaniemi, S, Gissler, M, Laivuori, H et al.. Gestational diabetes is associated with the risk of offspring’s congenital anomalies: a register-based cohort study. BMC Pregnancy Childbirth. 2023;23 (1):708. doi: 10.1186/s12884-023-05996-6. PubMed PMID:37789251 PubMed Central PMC10548673.
  10. Kivelä, A, Heinonen, S, Kivinen, K, Kere, J, Kajantie, E, Jääskeläinen, T et al.. Hypertensive pregnancy complications and maternal characteristics as predictors of cardiovascular health within ten years after delivery. Pregnancy Hypertens. 2023;34 :5-12. doi: 10.1016/j.preghy.2023.09.001. PubMed PMID:37708664 .
  11. Vuori, MA, Kiiskinen, T, Pitkänen, N, Kurki, S, Laivuori, H, Laitinen, T et al.. Use of electronic health record data mining for heart failure subtyping. BMC Res Notes. 2023;16 (1):208. doi: 10.1186/s13104-023-06469-x. PubMed PMID:37697398 PubMed Central PMC10496250.
  12. Westergaard, D, Steinthorsdottir, V, Stefansdottir, L, Rohde, PD, Wu, X, Geller, F et al.. Pregnancy-Associated Bleeding and Genetics: Five Sequence Variants in the Myometrium and Progesterone Signaling Pathway are associated with postpartum hemorrhage. medRxiv. 2023; :. doi: 10.1101/2023.08.10.23293932. PubMed PMID:37645979 PubMed Central PMC10462219.
  13. Mustaniemi, S, Keikkala, E, Kajantie, E, Nurhonen, M, Jylhä, A, Morin-Papunen, L et al.. Serum ceramides in early pregnancy as predictors of gestational diabetes. Sci Rep. 2023;13 (1):13274. doi: 10.1038/s41598-023-40224-3. PubMed PMID:37582815 PubMed Central PMC10427660.
  14. Julkunen, V, Schwarz, C, Kalapudas, J, Hallikainen, M, Piironen, AK, Mannermaa, A et al.. A FinnGen pilot clinical recall study for Alzheimer’s disease. Sci Rep. 2023;13 (1):12641. doi: 10.1038/s41598-023-39835-7. PubMed PMID:37537264 PubMed Central PMC10400697.
  15. Vest, T, Rantanen, K, Verho, L, Aarnio, K, Korhonen, A, Richardt, A et al.. Etiology of intracerebral hemorrhage during pregnancy or puerperium: A nationwide study. Eur J Neurol. 2024;31 (3):e16012. doi: 10.1111/ene.16012. PubMed PMID:37532682 .
  16. Viippola, E, Kuitunen, S, Rodosthenous, RS, Vabalas, A, Hartonen, T, Vartiainen, P et al.. Data Resource Profile: Nationwide registry data for high-throughput epidemiology and machine learning (FinRegistry). Int J Epidemiol. 2023;52 (4):e195-e200. doi: 10.1093/ije/dyad091. PubMed PMID:37365732 PubMed Central PMC10396416.
  17. Renlund, MA, Jääskeläinen, TJ, Kivelä, ASE, Heinonen, ST, Laivuori, HM, Sarkola, TA et al.. Blood pressure, arterial stiffness, and cardiovascular risk profiles in 8-12-year-old children following preeclampsia (FINNCARE-study). J Hypertens. 2023;41 (9):1429-1437. doi: 10.1097/HJH.0000000000003485. PubMed PMID:37337860 PubMed Central PMC10399950.
  18. Ågren, R, Patil, S, Zhou, X, FinnGen., Sahlholm, K, Pääbo, S et al.. Major Genetic Risk Factors for Dupuytren’s Disease Are Inherited From Neandertals. Mol Biol Evol. 2023;40 (6):. doi: 10.1093/molbev/msad130. PubMed PMID:37315093 PubMed Central PMC10266526.
  19. Jones, SE, Maisha, FI, Strausz, SJ, Lammi, V, Cade, BE, Tervi, A et al.. The public health impact of poor sleep on severe COVID-19, influenza and upper respiratory infections. EBioMedicine. 2023;93 :104630. doi: 10.1016/j.ebiom.2023.104630. PubMed PMID:37301713 PubMed Central PMC10248098.
  20. Tyrmi, JS, Kaartokallio, T, Lokki, AI, Jääskeläinen, T, Kortelainen, E, Ruotsalainen, S et al.. Genetic Risk Factors Associated With Preeclampsia and Hypertensive Disorders of Pregnancy. JAMA Cardiol. 2023;8 (7):674-683. doi: 10.1001/jamacardio.2023.1312. PubMed PMID:37285119 PubMed Central PMC10248811.
  21. Richardt, A, Aarnio, K, Korhonen, A, Rantanen, K, Verho, L, Laivuori, H et al.. Etiology and risk factors of ischemic stroke during pregnancy and puerperium: A population-based study. Eur Stroke J. 2023;8 (2):475-482. doi: 10.1177/23969873231170096. PubMed PMID:37231685 PubMed Central PMC10334185.
  22. Sormunen-Harju, H, Huvinen, E, Girchenko, PV, Kajantie, E, Villa, PM, Hämäläinen, EK et al.. Metabolomic Profiles of Nonobese and Obese Women With Gestational Diabetes. J Clin Endocrinol Metab. 2023;108 (11):2862-2870. doi: 10.1210/clinem/dgad288. PubMed PMID:37220084 PubMed Central PMC10584006.
  23. Miller, EC, Kauko, A, Tom, SE, Laivuori, H, Niiranen, T, Bello, NA et al.. Risk of Midlife Stroke After Adverse Pregnancy Outcomes: The FinnGen Study. Stroke. 2023;54 (7):1798-1805. doi: 10.1161/STROKEAHA.123.043052. PubMed PMID:37212139 PubMed Central PMC10330298.
  24. Ollila, HM, Sharon, E, Lin, L, Sinnott-Armstrong, N, Ambati, A, Yogeshwar, SM et al.. Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy. Nat Commun. 2023;14 (1):2709. doi: 10.1038/s41467-023-36120-z. PubMed PMID:37188663 PubMed Central PMC10185546.
  25. Lokki, AI, Ren, Z, Triebwasser, M, Daly, E, FINNPEC, Perola, M et al.. Identification of complement factor H variants that predispose to pre-eclampsia: A genetic and functional study. BJOG. 2023;130 (12):1473-1482. doi: 10.1111/1471-0528.17529. PubMed PMID:37156755 PubMed Central PMC10592561.
  26. Verho, L, Tikkanen, M, Äyräs, O, Aarnio, K, Rantanen, K, Korhonen, A et al.. Pregnancy-associated stroke and the recurrence of stroke and other complications in subsequent pregnancies: Population-based retrospective cohort study. BJOG. 2023;130 (11):1421-1429. doi: 10.1111/1471-0528.17503. PubMed PMID:37088716 .
  27. Lankinen, V, Helminen, M, Bakti, K, Välipakka, J, Laivuori, H, Hyvärinen, A et al.. Known risk factors of the developmental dysplasia of the hip predicting more severe clinical presentation and failure of Pavlik harness treatment. BMC Pediatr. 2023;23 (1):148. doi: 10.1186/s12887-023-03935-0. PubMed PMID:37004001 PubMed Central PMC10064754.
  28. Nurkkala, J, Kauko, A, FinnGen,, Laivuori, H, Saarela, T, Tyrmi, JS et al.. Associations of polygenic risk scores for preeclampsia and blood pressure with hypertensive disorders of pregnancy. J Hypertens. 2023;41 (3):380-387. doi: 10.1097/HJH.0000000000003336. PubMed PMID:36947680 PubMed Central PMC9894151.
  29. Koel, M, Võsa, U, Jõeloo, M, Läll, K, Gualdo, NP, Laivuori, H et al.. GWAS meta-analyses clarify the genetics of cervical phenotypes and inform risk stratification for cervical cancer. Hum Mol Genet. 2023;32 (12):2103-2116. doi: 10.1093/hmg/ddad043. PubMed PMID:36929174 PubMed Central PMC10244231.
  30. Rahmioglu, N, Mortlock, S, Ghiasi, M, Møller, PL, Stefansdottir, L, Galarneau, G et al.. The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions. Nat Genet. 2023;55 (3):423-436. doi: 10.1038/s41588-023-01323-z. PubMed PMID:36914876 PubMed Central PMC10042257.
  31. Kurki, MI, Karjalainen, J, Palta, P, Sipilä, TP, Kristiansson, K, Donner, KM et al.. Author Correction: FinnGen provides genetic insights from a well-phenotyped isolated population. Nature. 2023;615 (7952):E19. doi: 10.1038/s41586-023-05837-8. PubMed PMID:36829046 PubMed Central PMC10017492.
  32. Sliz, E, Tyrmi, JS, Rahmioglu, N, Zondervan, KT, Becker, CM, FinnGen et al.. Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata. Nat Commun. 2023;14 (1):542. doi: 10.1038/s41467-023-35974-7. PubMed PMID:36726022 PubMed Central PMC9892568.
  33. Kurki, MI, Karjalainen, J, Palta, P, Sipilä, TP, Kristiansson, K, Donner, KM et al.. FinnGen provides genetic insights from a well-phenotyped isolated population. Nature. 2023;613 (7944):508-518. doi: 10.1038/s41586-022-05473-8. PubMed PMID:36653562 PubMed Central PMC9849126.
  34. Mustaniemi, S, Morin-Papunen, L, Keikkala, E, Öhman, H, Surcel, HM, Kaaja, R et al.. Associations of low sex hormone-binding globulin and androgen excess in early pregnancy with fasting and post-prandial hyperglycaemia, gestational diabetes, and its severity. Diabetes Metab Res Rev. 2023;39 (2):e3599. doi: 10.1002/dmrr.3599. PubMed PMID:36484476 PubMed Central PMC10078580.
  35. Korhonen, A, Verho, L, Aarnio, K, Rantanen, K, Saaros, A, Laivuori, H et al.. Subarachnoid Hemorrhage During Pregnancy and Puerperium: A Population-Based Study. Stroke. 2023;54 (1):198-207. doi: 10.1161/STROKEAHA.122.039235. PubMed PMID:36321452 .
  36. Airikka, A, Lahti-Pulkkinen, M, Tuovinen, S, Heinonen, K, Lahti, J, Girchenko, P et al.. Maternal exposure to childhood maltreatment and mental and behavioral disorders in children. Eur Child Adolesc Psychiatry. 2023;32 (12):2463-2475. doi: 10.1007/s00787-022-02090-8. PubMed PMID:36181574 PubMed Central PMC10682113.
  37. Kekki, M, Koukkula, T, Salonen, A, Gissler, M, Laivuori, H, Huttunen, TT et al.. Birth injury in breech delivery: a nationwide population-based cohort study in Finland. Arch Gynecol Obstet. 2023;308 (4):1139-1150. doi: 10.1007/s00404-022-06772-1. PubMed PMID:36074174 PubMed Central PMC10435420.
  38. Kekki, M, Salonen, A, Koukkula, T, Laivuori, H, Tihtonen, K, Huttunen, TT et al.. Incidence changes in risk factors associated with the decreasing number of birth-related clavicle fractures in Finland: A nationwide retrospective birth cohort from 2004 to 2017. Birth. 2023;50 (2):428-437. doi: 10.1111/birt.12662. PubMed PMID:35735132 .
  39. Lähdepuro, A, Lahti-Pulkkinen, M, Pyhälä, R, Tuovinen, S, Lahti, J, Heinonen, K et al.. Positive maternal mental health during pregnancy and mental and behavioral disorders in children: A prospective pregnancy cohort study. J Child Psychol Psychiatry. 2023;64 (5):807-816. doi: 10.1111/jcpp.13625. PubMed PMID:35524467 .

Search PubMed

2022

  1. Nurkkala, J, Kauko, A, FinnGen,, Laivuori, H, Saarela, T, Tyrmi, JS et al.. Associations of polygenic risk scores for preeclampsia and blood pressure with hypertensive disorders of pregnancy. J Hypertens. 2023;41 (3):380-387. doi: 10.1097/HJH.0000000000003336. PubMed PMID:36947680 PubMed Central PMC9894151.
  2. Perez-Villatoro, F, Oikkonen, J, Casado, J, Chernenko, A, Gulhan, DC, Tumiati, M et al.. Optimized detection of homologous recombination deficiency improves the prediction of clinical outcomes in cancer. NPJ Precis Oncol. 2022;6 (1):96. doi: 10.1038/s41698-022-00339-8. PubMed PMID:36581696 PubMed Central PMC9800569.
  3. Bakti, K, Lankinen, V, Helminen, M, Välipakka, J, Laivuori, H, Hyvärinen, A et al.. Clinical and sonographic improvement of developmental dysplasia of the hip: analysis of 948 patients. J Orthop Surg Res. 2022;17 (1):538. doi: 10.1186/s13018-022-03432-7. PubMed PMID:36510263 PubMed Central PMC9743506.
  4. Sheikh, J, Allotey, J, Kew, T, Fernández-Félix, BM, Zamora, J, Khalil, A et al.. Effects of race and ethnicity on perinatal outcomes in high-income and upper-middle-income countries: an individual participant data meta-analysis of 2 198 655 pregnancies. Lancet. 2022;400 (10368):2049-2062. doi: 10.1016/S0140-6736(22)01191-6. PubMed PMID:36502843 .
  5. Mustaniemi, S, Morin-Papunen, L, Keikkala, E, Öhman, H, Surcel, HM, Kaaja, R et al.. Associations of low sex hormone-binding globulin and androgen excess in early pregnancy with fasting and post-prandial hyperglycaemia, gestational diabetes, and its severity. Diabetes Metab Res Rev. 2023;39 (2):e3599. doi: 10.1002/dmrr.3599. PubMed PMID:36484476 PubMed Central PMC10078580.
  6. Korhonen, A, Verho, L, Aarnio, K, Rantanen, K, Saaros, A, Laivuori, H et al.. Subarachnoid Hemorrhage During Pregnancy and Puerperium: A Population-Based Study. Stroke. 2023;54 (1):198-207. doi: 10.1161/STROKEAHA.122.039235. PubMed PMID:36321452 .
  7. Czamara, D, Cruceanu, C, Lahti-Pulkkinen, M, Dieckmann, L, Ködel, M, Sauer, S et al.. Genome-Wide Copy Number Variant and High-Throughput Transcriptomics Analyses of Placental Tissues Underscore Persisting Child Susceptibility in At-Risk Pregnancies Cleared in Standard Genetic Testing. Int J Mol Sci. 2022;23 (19):. doi: 10.3390/ijms231911448. PubMed PMID:36232765 PubMed Central PMC9569583.
  8. Rodosthenous, RS, Niemi, MEK, Kallio, L, Perala, M, Terho, P, Knopp, T et al.. Recontacting biobank participants to collect lifestyle, behavioural and cognitive information via online questionnaires: lessons from a pilot study within FinnGen. BMJ Open. 2022;12 (10):e064695. doi: 10.1136/bmjopen-2022-064695. PubMed PMID:36198465 PubMed Central PMC9535212.
  9. Airikka, A, Lahti-Pulkkinen, M, Tuovinen, S, Heinonen, K, Lahti, J, Girchenko, P et al.. Maternal exposure to childhood maltreatment and mental and behavioral disorders in children. Eur Child Adolesc Psychiatry. 2023;32 (12):2463-2475. doi: 10.1007/s00787-022-02090-8. PubMed PMID:36181574 PubMed Central PMC10682113.
  10. Pukkila, J, Mustaniemi, S, Lingaiah, S, Lappalainen, OP, Kajantie, E, Pouta, A et al.. Increased Oral Care Needs and Third Molar Symptoms in Women with Gestational Diabetes Mellitus: A Finnish Gestational Diabetes Case-Control Study. Int J Environ Res Public Health. 2022;19 (17):. doi: 10.3390/ijerph191710711. PubMed PMID:36078430 PubMed Central PMC9518339.
  11. Kekki, M, Koukkula, T, Salonen, A, Gissler, M, Laivuori, H, Huttunen, TT et al.. Birth injury in breech delivery: a nationwide population-based cohort study in Finland. Arch Gynecol Obstet. 2023;308 (4):1139-1150. doi: 10.1007/s00404-022-06772-1. PubMed PMID:36074174 PubMed Central PMC10435420.
  12. Ruotsalainen, SE, Surakka, I, Mars, N, Karjalainen, J, Kurki, M, Kanai, M et al.. Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis. Commun Biol. 2022;5 (1):802. doi: 10.1038/s42003-022-03552-0. PubMed PMID:35978133 PubMed Central PMC9385630.
  13. Girchenko, P, Lahti-Pulkkinen, M, Lipsanen, J, Heinonen, K, Lahti, J, Rantalainen, V et al.. Maternal early-pregnancy body mass index-associated metabolomic component and mental and behavioral disorders in children. Mol Psychiatry. 2022;27 (11):4653-4661. doi: 10.1038/s41380-022-01723-3. PubMed PMID:35948657 PubMed Central PMC9734035.
  14. Kivioja, A, Toivonen, E, Tyrmi, J, Ruotsalainen, S, Ripatti, S, Huhtala, H et al.. Increased Risk of Preeclampsia in Women With a Genetic Predisposition to Elevated Blood Pressure. Hypertension. 2022;79 (9):2008-2015. doi: 10.1161/HYPERTENSIONAHA.122.18996. PubMed PMID:35862124 PubMed Central PMC9370253.
  15. Kekki, M, Salonen, A, Koukkula, T, Laivuori, H, Tihtonen, K, Huttunen, TT et al.. Incidence changes in risk factors associated with the decreasing number of birth-related clavicle fractures in Finland: A nationwide retrospective birth cohort from 2004 to 2017. Birth. 2023;50 (2):428-437. doi: 10.1111/birt.12662. PubMed PMID:35735132 .
  16. Lähdepuro, A, Lahti-Pulkkinen, M, Pyhälä, R, Tuovinen, S, Lahti, J, Heinonen, K et al.. Positive maternal mental health during pregnancy and mental and behavioral disorders in children: A prospective pregnancy cohort study. J Child Psychol Psychiatry. 2023;64 (5):807-816. doi: 10.1111/jcpp.13625. PubMed PMID:35524467 .
  17. Huvinen, E, Lahti, J, Klemetti, MM, Bergman, PH, Räikkönen, K, Orho-Melander, M et al.. Genetic risk of type 2 diabetes modifies the effects of a lifestyle intervention aimed at the prevention of gestational and postpartum diabetes. Diabetologia. 2022;65 (8):1291-1301. doi: 10.1007/s00125-022-05712-7. PubMed PMID:35501401 PubMed Central PMC9283155.
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2021

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2020

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2019

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  12. Ukah, UV, Payne, B, Karjalainen, H, Kortelainen, E, Seed, PT, Conti-Ramsden, FI et al.. Temporal and external validation of the fullPIERS model for the prediction of adverse maternal outcomes in women with pre-eclampsia. Pregnancy Hypertens. 2019;15 :42-50. doi: 10.1016/j.preghy.2018.01.004. PubMed PMID:30825926 .
  13. Toffol, E, Lahti-Pulkkinen, M, Lahti, J, Lipsanen, J, Heinonen, K, Pesonen, AK et al.. Maternal depressive symptoms during and after pregnancy are associated with poorer sleep quantity and quality and sleep disorders in 3.5-year-old offspring. Sleep Med. 2019;56 :201-210. doi: 10.1016/j.sleep.2018.10.042. PubMed PMID:30819657 .
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Search PubMed

2018

  1. Ukah, UV, Payne, B, Karjalainen, H, Kortelainen, E, Seed, PT, Conti-Ramsden, FI et al.. Temporal and external validation of the fullPIERS model for the prediction of adverse maternal outcomes in women with pre-eclampsia. Pregnancy Hypertens. 2019;15 :42-50. doi: 10.1016/j.preghy.2018.01.004. PubMed PMID:30825926 .
  2. Toffol, E, Lahti-Pulkkinen, M, Lahti, J, Lipsanen, J, Heinonen, K, Pesonen, AK et al.. Maternal depressive symptoms during and after pregnancy are associated with poorer sleep quantity and quality and sleep disorders in 3.5-year-old offspring. Sleep Med. 2019;56 :201-210. doi: 10.1016/j.sleep.2018.10.042. PubMed PMID:30819657 .
  3. Lokki, AI, Heikkinen-Eloranta, JK, Laivuori, H. The Immunogenetic Conundrum of Preeclampsia. Front Immunol. 2018;9 :2630. doi: 10.3389/fimmu.2018.02630. PubMed PMID:30483272 PubMed Central PMC6243043.
  4. Toffol, E, Rantalainen, V, Lahti-Pulkkinen, M, Girchenko, P, Lahti, J, Tuovinen, S et al.. Infant regulatory behavior problems during first month of life and neurobehavioral outcomes in early childhood. Eur Child Adolesc Psychiatry. 2019;28 (6):847-859. doi: 10.1007/s00787-018-1243-8. PubMed PMID:30392118 PubMed Central PMC6555774.
  5. Girchenko, P, Lahti-Pulkkinen, M, Lahti, J, Pesonen, AK, Hämäläinen, E, Villa, PM et al.. Neonatal regulatory behavior problems are predicted by maternal early pregnancy overweight and obesity: findings from the prospective PREDO Study. Pediatr Res. 2018;84 (6):875-881. doi: 10.1038/s41390-018-0199-1. PubMed PMID:30305694 .
  6. Jääskeläinen, T, Kärkkäinen, O, Jokkala, J, Litonius, K, Heinonen, S, Auriola, S et al.. A Non-Targeted LC-MS Profiling Reveals Elevated Levels of Carnitine Precursors and Trimethylated Compounds in the Cord Plasma of Pre-Eclamptic Infants. Sci Rep. 2018;8 (1):14616. doi: 10.1038/s41598-018-32804-5. PubMed PMID:30279541 PubMed Central PMC6168522.
  7. Jääskeläinen, T, Heinonen, S, Hämäläinen, E, Pulkki, K, Romppanen, J, Laivuori, H et al.. Impact of obesity on angiogenic and inflammatory markers in the Finnish Genetics of Pre-eclampsia Consortium (FINNPEC) cohort. Int J Obes (Lond). 2019;43 (5):1070-1081. doi: 10.1038/s41366-018-0217-8. PubMed PMID:30254363 .
  8. Rönö, K, Stach-Lempinen, B, Eriksson, JG, Pöyhönen-Alho, M, Klemetti, MM, Roine, RP et al.. Prevention of gestational diabetes with a prepregnancy lifestyle intervention – findings from a randomized controlled trial. Int J Womens Health. 2018;10 :493-501. doi: 10.2147/IJWH.S162061. PubMed PMID:30214318 PubMed Central PMC6118269.
  9. Rönö, K, Grotenfelt, NE, Klemetti, MM, Stach-Lempinen, B, Huvinen, E, Meinilä, J et al.. Effect of a lifestyle intervention during pregnancy-findings from the Finnish gestational diabetes prevention trial (RADIEL). J Perinatol. 2018;38 (9):1157-1164. doi: 10.1038/s41372-018-0178-8. PubMed PMID:30042471 .
  10. Murtoniemi, K, Villa, PM, Matomäki, J, Keikkala, E, Vuorela, P, Hämäläinen, E et al.. Prediction of pre-eclampsia and its subtypes in high-risk cohort: hyperglycosylated human chorionic gonadotropin in multivariate models. BMC Pregnancy Childbirth. 2018;18 (1):279. doi: 10.1186/s12884-018-1908-9. PubMed PMID:29970026 PubMed Central PMC6029382.
  11. Mustaniemi, S, Vääräsmäki, M, Eriksson, JG, Gissler, M, Laivuori, H, Ijäs, H et al.. Polycystic ovary syndrome and risk factors for gestational diabetes. Endocr Connect. 2018;7 (7):859-869. doi: 10.1530/EC-18-0076. PubMed PMID:29858213 PubMed Central PMC6026881.
  12. Jääskeläinen, T, Heinonen, S, Hämäläinen, E, Pulkki, K, Romppanen, J, Laivuori, H et al.. Angiogenic profile in the Finnish Genetics of Pre-Eclampsia Consortium (FINNPEC) cohort. Pregnancy Hypertens. 2018;14 :252-259. doi: 10.1016/j.preghy.2018.03.004. PubMed PMID:29803331 .
  13. Suarez, A, Lahti, J, Czamara, D, Lahti-Pulkkinen, M, Knight, AK, Girchenko, P et al.. The Epigenetic Clock at Birth: Associations With Maternal Antenatal Depression and Child Psychiatric Problems. J Am Acad Child Adolesc Psychiatry. 2018;57 (5):321-328.e2. doi: 10.1016/j.jaac.2018.02.011. PubMed PMID:29706161 PubMed Central PMC6277971.
  14. Girchenko, P, Tuovinen, S, Lahti-Pulkkinen, M, Lahti, J, Savolainen, K, Heinonen, K et al.. Maternal early pregnancy obesity and related pregnancy and pre-pregnancy disorders: associations with child developmental milestones in the prospective PREDO Study. Int J Obes (Lond). 2018;42 (5):995-1007. doi: 10.1038/s41366-018-0061-x. PubMed PMID:29686379 .
  15. Tuovinen, S, Lahti-Pulkkinen, M, Girchenko, P, Lipsanen, J, Lahti, J, Heinonen, K et al.. Maternal depressive symptoms during and after pregnancy and child developmental milestones. Depress Anxiety. 2018;35 (8):732-741. doi: 10.1002/da.22756. PubMed PMID:29667739 .
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  18. Lahti-Pulkkinen, M, Cudmore, MJ, Haeussner, E, Schmitz, C, Pesonen, AK, Hämäläinen, E et al.. Placental Morphology Is Associated with Maternal Depressive Symptoms during Pregnancy and Toddler Psychiatric Problems. Sci Rep. 2018;8 (1):791. doi: 10.1038/s41598-017-19133-9. PubMed PMID:29335435 PubMed Central PMC5768752.
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  20. Kaartokallio, T, Utge, S, Klemetti, MM, Paananen, J, Pulkki, K, Romppanen, J et al.. Fetal Microsatellite in the Heme Oxygenase 1 Promoter Is Associated With Severe and Early-Onset Preeclampsia. Hypertension. 2018;71 (1):95-102. doi: 10.1161/HYPERTENSIONAHA.117.10425. PubMed PMID:29203625 .

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2017

  1. Wolford, E, Lahti, M, Tuovinen, S, Lahti, J, Lipsanen, J, Savolainen, K et al.. Maternal depressive symptoms during and after pregnancy are associated with attention-deficit/hyperactivity disorder symptoms in their 3- to 6-year-old children. PLoS One. 2017;12 (12):e0190248. doi: 10.1371/journal.pone.0190248. PubMed PMID:29267405 PubMed Central PMC5739495.
  2. Kaartokallio, T, Utge, S, Klemetti, MM, Paananen, J, Pulkki, K, Romppanen, J et al.. Fetal Microsatellite in the Heme Oxygenase 1 Promoter Is Associated With Severe and Early-Onset Preeclampsia. Hypertension. 2018;71 (1):95-102. doi: 10.1161/HYPERTENSIONAHA.117.10425. PubMed PMID:29203625 .
  3. Lokki, AI, Daly, E, Triebwasser, M, Kurki, MI, Roberson, EDO, Häppölä, P et al.. Protective Low-Frequency Variants for Preeclampsia in the Fms Related Tyrosine Kinase 1 Gene in the Finnish Population. Hypertension. 2017;70 (2):365-371. doi: 10.1161/HYPERTENSIONAHA.117.09406. PubMed PMID:28652462 PubMed Central PMC5535812.
  4. McGinnis, R, Steinthorsdottir, V, Williams, NO, Thorleifsson, G, Shooter, S, Hjartardottir, S et al.. Variants in the fetal genome near FLT1 are associated with risk of preeclampsia. Nat Genet. 2017;49 (8):1255-1260. doi: 10.1038/ng.3895. PubMed PMID:28628106 .
  5. Koivusalo, SB, Rönö, K, Klemetti, MM, Roine, RP, Lindström, J, Erkkola, M et al.. Erratum. Gestational Diabetes Mellitus Can Be Prevented by Lifestyle Intervention: The Finnish Gestational Diabetes Prevention Study (RADIEL). A Randomized Controlled Trial. Diabetes Care 2016;39:24-30. Diabetes Care. 2017;40 (8):1133. doi: 10.2337/dc17-er08a. PubMed PMID:28615238 PubMed Central PMC5521976.
  6. Lokki, AI, Kaartokallio, T, Holmberg, V, Onkamo, P, Koskinen, LLE, Saavalainen, P et al.. Analysis of Complement C3 Gene Reveals Susceptibility to Severe Preeclampsia. Front Immunol. 2017;8 :589. doi: 10.3389/fimmu.2017.00589. PubMed PMID:28611769 PubMed Central PMC5446983.
  7. Jääskeläinen, T, Suomalainen-König, S, Hämäläinen, E, Pulkki, K, Romppanen, J, Heinonen, S et al.. Angiogenic profile and smoking in the Finnish Genetics of Pre-Eclampsia Consortium (FINNPEC) cohort. Ann Med. 2017;49 (7):593-602. doi: 10.1080/07853890.2017.1335427. PubMed PMID:28537456 .
  8. Girchenko, P, Lahti, J, Czamara, D, Knight, AK, Jones, MJ, Suarez, A et al.. Associations between maternal risk factors of adverse pregnancy and birth outcomes and the offspring epigenetic clock of gestational age at birth. Clin Epigenetics. 2017;9 :49. doi: 10.1186/s13148-017-0349-z. PubMed PMID:28503212 PubMed Central PMC5422977.
  9. Hirvonen, K, Laivuori, H, Lahti, J, Strandberg, T, Eriksson, JG, Hackman, P et al.. SIRT6 polymorphism rs117385980 is associated with longevity and healthy aging in Finnish men. BMC Med Genet. 2017;18 (1):41. doi: 10.1186/s12881-017-0401-z. PubMed PMID:28399814 PubMed Central PMC5387321.
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  11. Lahti, M, Savolainen, K, Tuovinen, S, Pesonen, AK, Lahti, J, Heinonen, K et al.. Maternal Depressive Symptoms During and After Pregnancy and Psychiatric Problems in Children. J Am Acad Child Adolesc Psychiatry. 2017;56 (1):30-39.e7. doi: 10.1016/j.jaac.2016.10.007. PubMed PMID:27993226 .
  12. Girchenko, P, Lahti, M, Tuovinen, S, Savolainen, K, Lahti, J, Binder, EB et al.. Cohort Profile: Prediction and prevention of preeclampsia and intrauterine growth restriction (PREDO) study. Int J Epidemiol. 2017;46 (5):1380-1381g. doi: 10.1093/ije/dyw154. PubMed PMID:27639277 .
  13. Global Pregnancy Collaboration:, Schalekamp-Timmermans, S, Arends, LR, Alsaker, E, Chappell, L, Hansson, S et al.. Fetal sex-specific differences in gestational age at delivery in pre-eclampsia: a meta-analysis. Int J Epidemiol. 2017;46 (2):632-642. doi: 10.1093/ije/dyw178. PubMed PMID:27605586PubMed Central PMC5837300.

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2016

  1. Jääskeläinen, T, Heinonen, S, Kajantie, E, Kere, J, Kivinen, K, Pouta, A et al.. Cohort profile: the Finnish Genetics of Pre-eclampsia Consortium (FINNPEC). BMJ Open. 2016;6 (11):e013148. doi: 10.1136/bmjopen-2016-013148. PubMed PMID:28067621 PubMed Central PMC5129003.
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  3. Keikkala, E, Koskinen, S, Vuorela, P, Laivuori, H, Romppanen, J, Heinonen, S et al.. First trimester serum placental growth factor and hyperglycosylated human chorionic gonadotropin are associated with pre-eclampsia: a case control study. BMC Pregnancy Childbirth. 2016;16 (1):378. doi: 10.1186/s12884-016-1169-4. PubMed PMID:27887594 PubMed Central PMC5124279.
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  5. Wang, J, Skoog, T, Einarsdottir, E, Kaartokallio, T, Laivuori, H, Grauers, A et al.. Investigation of rare and low-frequency variants using high-throughput sequencing with pooled DNA samples. Sci Rep. 2016;6 :33256. doi: 10.1038/srep33256. PubMed PMID:27633116 PubMed Central PMC5025741.
  6. Juhanson, P, Rull, K, Kikas, T, Laivuori, H, Vaas, P, Kajantie, E et al.. Stanniocalcin-1 Hormone in Nonpreeclamptic and Preeclamptic Pregnancy: Clinical, Life-Style, and Genetic Modulators. J Clin Endocrinol Metab. 2016;101 (12):4799-4807. doi: 10.1210/jc.2016-1873. PubMed PMID:27603899 PubMed Central PMC5155696.
  7. Karppanen, T, Kaartokallio, T, Klemetti, MM, Heinonen, S, Kajantie, E, Kere, J et al.. An RGS2 3’UTR polymorphism is associated with preeclampsia in overweight women. BMC Genet. 2016;17 (1):121. doi: 10.1186/s12863-016-0428-8. PubMed PMID:27558088 PubMed Central PMC4997762.
  8. Kallela, J, Jääskeläinen, T, Kortelainen, E, Heinonen, S, Kajantie, E, Kere, J et al.. The diagnosis of pre-eclampsia using two revised classifications in the Finnish Pre-eclampsia Consortium (FINNPEC) cohort. BMC Pregnancy Childbirth. 2016;16 :221. doi: 10.1186/s12884-016-1010-0. PubMed PMID:27520381PubMed Central PMC4983019.
  9. Kaartokallio, T, Wang, J, Heinonen, S, Kajantie, E, Kivinen, K, Pouta, A et al.. Exome sequencing in pooled DNA samples to identify maternal pre-eclampsia risk variants. Sci Rep. 2016;6 :29085. doi: 10.1038/srep29085. PubMed PMID:27384325 PubMed Central PMC4935848.
  10. Grotenfelt, NE, Wasenius, NS, Rönö, K, Laivuori, H, Stach-Lempinen, B, Orho-Melander, M et al.. Interaction between rs10830963 polymorphism in MTNR1B and lifestyle intervention on occurrence of gestational diabetes. Diabetologia. 2016;59 (8):1655-8. doi: 10.1007/s00125-016-3989-1. PubMed PMID:27209463 .
  11. Kaartokallio, T, Lokki, AI, Peterson, H, Kivinen, K, Hiltunen, L, Salmela, E et al.. Preeclampsia does not share common risk alleles in 9p21 with coronary artery disease and type 2 diabetes. Ann Med. 2016;48 (5):330-6. doi: 10.1080/07853890.2016.1174877. PubMed PMID:27111527 .
  12. Burke, Ó, Benton, S, Szafranski, P, von Dadelszen, P, Buhimschi, SC, Cetin, I et al.. Extending the scope of pooled analyses of individual patient biomarker data from heterogeneous laboratory platforms and cohorts using merging algorithms. Pregnancy Hypertens. 2016;6 (1):53-9. doi: 10.1016/j.preghy.2015.12.002. PubMed PMID:26955773 .
  13. Pesonen, AK, Lahti, M, Kuusinen, T, Tuovinen, S, Villa, P, Hämäläinen, E et al.. Maternal Prenatal Positive Affect, Depressive and Anxiety Symptoms and Birth Outcomes: The PREDO Study. PLoS One. 2016;11 (2):e0150058. doi: 10.1371/journal.pone.0150058. PubMed PMID:26919119 PubMed Central PMC4769149.
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  15. Reichhardt, MP, Jarva, H, Lokki, AI, Laivuori, H, FINNPEC study group, Vuorela, P et al.. The Salivary Scavenger and Agglutinin (SALSA) in Healthy and Complicated Pregnancy. PLoS One. 2016;11 (2):e0147867. doi: 10.1371/journal.pone.0147867. PubMed PMID:26828433 PubMed Central PMC4734712.
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