Publications since 2016

2021

  1. Mäkinen, A, Nikkilä, A, Mehtonen, J, Teppo, S, Oksa, L, Nordlund, J et al.. Expression of BCL6 in paediatric B-cell acute lymphoblastic leukaemia and association with prognosis. Pathology. 2021; :. doi: 10.1016/j.pathol.2021.02.013. PubMed PMID:34049715 .
  2. Mäkinen, A, Nikkilä, A, Haapaniemi, T, Oksa, L, Mehtonen, J, Vänskä, M et al.. IGF2BP3 Associates with Proliferative Phenotype and Prognostic Features in B-Cell Acute Lymphoblastic Leukemia. Cancers (Basel). 2021;13 (7):. doi: 10.3390/cancers13071505. PubMed PMID:33805930 PubMed Central PMC8037952.
  3. Winter, G, Kirschner-Schwabe, R, Groeneveld-Krentz, S, Escherich, G, Möricke, A, von Stackelberg, A et al.. Clinical and genetic characteristics of children with acute lymphoblastic leukemia and Li-Fraumeni syndrome. Leukemia. 2021;35 (5):1475-1479. doi: 10.1038/s41375-021-01163-y. PubMed PMID:33580201 PubMed Central PMC8102191.

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2020

  1. Abuhamed, J, Nikkilä, A, Lohi, O, Auvinen, A. Trends of computed tomography use among children in Finland. Eur J Radiol Open. 2020;7 :100290. doi: 10.1016/j.ejro.2020.100290. PubMed PMID:33335951 PubMed Central PMC7733003.
  2. Mehtonen, J, Teppo, S, Lahnalampi, M, Kokko, A, Kaukonen, R, Oksa, L et al.. Single cell characterization of B-lymphoid differentiation and leukemic cell states during chemotherapy in ETV6-RUNX1-positive pediatric leukemia identifies drug-targetable transcription factor activities. Genome Med. 2020;12 (1):99. doi: 10.1186/s13073-020-00799-2. PubMed PMID:33218352 PubMed Central PMC7679990.
  3. Dufva, O, Pölönen, P, Brück, O, Keränen, MAI, Klievink, J, Mehtonen, J et al.. Immunogenomic Landscape of Hematological Malignancies. Cancer Cell. 2020;38 (3):424-428. doi: 10.1016/j.ccell.2020.08.019. PubMed PMID:32931743 .
  4. Laukkanen, S, Oksa, L, Nikkilä, A, Lahnalampi, M, Parikka, M, Seki, M et al.. SIX6 is a TAL1-regulated transcription factor in T-ALL and associated with inferior outcome. Leuk Lymphoma. 2020;61 (13):3089-3100. doi: 10.1080/10428194.2020.1804560. PubMed PMID:32835548 .
  5. Immonen, E, Aine, L, Nikkilä, A, Parikka, M, Grönroos, M, Vepsäläinen, K et al.. Randomized controlled and double-blinded study of Caphosol versus saline oral rinses in pediatric patients with cancer. Pediatr Blood Cancer. 2020;67 (10):e28520. doi: 10.1002/pbc.28520. PubMed PMID:32725875 .
  6. Chan, LN, Murakami, MA, Robinson, ME, Caeser, R, Sadras, T, Lee, J et al.. Signalling input from divergent pathways subverts B cell transformation. Nature. 2020;583 (7818):845-851. doi: 10.1038/s41586-020-2513-4. PubMed PMID:32699415 PubMed Central PMC7394729.
  7. Dufva, O, Pölönen, P, Brück, O, Keränen, MAI, Klievink, J, Mehtonen, J et al.. Immunogenomic Landscape of Hematological Malignancies. Cancer Cell. 2020;38 (3):380-399.e13. doi: 10.1016/j.ccell.2020.06.002. PubMed PMID:32649887 .
  8. Karalexi, MA, Dessypris, N, Ma, X, Spector, LG, Marcotte, E, Clavel, J et al.. Age-, sex- and disease subtype-related foetal growth differentials in childhood acute myeloid leukaemia risk: A Childhood Leukemia International Consortium analysis. Eur J Cancer. 2020;130 :1-11. doi: 10.1016/j.ejca.2020.01.018. PubMed PMID:32163883 .
  9. Nikkilä, A, Raitanen, J, Lohi, O, Auvinen, A. Radiation exposure from computerized tomography and risk of childhood leukemia: Finnish register-based case-control study of childhood leukemia (FRECCLE). Haematologica. 2020;105 (3):849-850. doi: 10.3324/haematol.2019.245704. PubMed PMID:32115415 PubMed Central PMC7049358.
  10. Grönroos, T, Mäkinen, A, Laukkanen, S, Mehtonen, J, Nikkilä, A, Oksa, L et al.. Clinicopathological features and prognostic value of SOX11 in childhood acute lymphoblastic leukemia. Sci Rep. 2020;10 (1):2043. doi: 10.1038/s41598-020-58970-z. PubMed PMID:32029838 PubMed Central PMC7005266.
  11. Nikkilä, A, Arvela, H, Mehtonen, J, Raitanen, J, Heinäniemi, M, Lohi, O et al.. Predicting residential radon concentrations in Finland: Model development, validation, and application to childhood leukemia. Scand J Work Environ Health. 2020;46 (3):278-292. doi: 10.5271/sjweh.3867. PubMed PMID:31763683 .
  12. Harjula, SE, Saralahti, AK, Ojanen, MJT, Rantapero, T, Uusi-Mäkelä, MIE, Nykter, M et al.. Characterization of immune response against Mycobacterium marinum infection in the main hematopoietic organ of adult zebrafish (Danio rerio). Dev Comp Immunol. 2020;103 :103523. doi: 10.1016/j.dci.2019.103523. PubMed PMID:31626817 .
  13. Heikkilä, P, Kokko, P, Lohi, O, Korppi, M. Nursing intensity scores did not correlate well with reimbursement claims for infant bronchiolitis. Acta Paediatr. 2020;109 (1):140-146. doi: 10.1111/apa.14926. PubMed PMID:31269265 .

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2019

  1. Karppinen, S, Lohi, O, Vihola, M. Prediction of leukocyte counts during paediatric acute lymphoblastic leukaemia maintenance therapy. Sci Rep. 2019;9 (1):18076. doi: 10.1038/s41598-019-54492-5. PubMed PMID:31792398 PubMed Central PMC6889389.
  2. Nikkilä, A, Arvela, H, Mehtonen, J, Raitanen, J, Heinäniemi, M, Lohi, O et al.. Predicting residential radon concentrations in Finland: Model development, validation, and application to childhood leukemia. Scand J Work Environ Health. 2020;46 (3):278-292. doi: 10.5271/sjweh.3867. PubMed PMID:31763683 .
  3. Harjula, SE, Saralahti, AK, Ojanen, MJT, Rantapero, T, Uusi-Mäkelä, MIE, Nykter, M et al.. Characterization of immune response against Mycobacterium marinum infection in the main hematopoietic organ of adult zebrafish (Danio rerio). Dev Comp Immunol. 2020;103 :103523. doi: 10.1016/j.dci.2019.103523. PubMed PMID:31626817 .
  4. Talibov, M, Olsson, A, Bailey, H, Erdmann, F, Metayer, C, Magnani, C et al.. Parental occupational exposure to low-frequency magnetic fields and risk of leukaemia in the offspring: findings from the Childhood Leukaemia International Consortium (CLIC). Occup Environ Med. 2019;76 (10):746-753. doi: 10.1136/oemed-2019-105706. PubMed PMID:31358566 PubMed Central PMC6817988.
  5. Mehtonen, J, Pölönen, P, Häyrynen, S, Dufva, O, Lin, J, Liuksiala, T et al.. Data-driven characterization of molecular phenotypes across heterogeneous sample collections. Nucleic Acids Res. 2019;47 (13):e76. doi: 10.1093/nar/gkz281. PubMed PMID:31329928 PubMed Central PMC6648337.
  6. Heikkilä, P, Kokko, P, Lohi, O, Korppi, M. Nursing intensity scores did not correlate well with reimbursement claims for infant bronchiolitis. Acta Paediatr. 2020;109 (1):140-146. doi: 10.1111/apa.14926. PubMed PMID:31269265 .
  7. Pölönen, P, Mehtonen, J, Lin, J, Liuksiala, T, Häyrynen, S, Teppo, S et al.. Hemap: An Interactive Online Resource for Characterizing Molecular Phenotypes across Hematologic Malignancies. Cancer Res. 2019;79 (10):2466-2479. doi: 10.1158/0008-5472.CAN-18-2970. PubMed PMID:30940663 .
  8. Wolthers, BO, Mogensen, PR, Frandsen, TL, Abrahamsson, J, Behrendtz, M, Heyman, M et al.. Insulin-dependent diabetes: A chronic complication to acute pancreatitis in childhood acute lymphoblastic leukemia. Pediatr Blood Cancer. 2019;66 (1):e27437. doi: 10.1002/pbc.27437. PubMed PMID:30216644 .
  9. Poukka, M, Lund-Aho, T, Raittinen, P, Nikkilä, A, Kivinen, K, Lundán, T et al.. Acute Lymphoblastic Leukemia With INPP5D-ABL1 Fusion Responds to Imatinib Treatment. J Pediatr Hematol Oncol. 2019;41 (7):e481-e483. doi: 10.1097/MPH.0000000000001267. PubMed PMID:30045148 .

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2018

  1. Wolthers, BO, Mogensen, PR, Frandsen, TL, Abrahamsson, J, Behrendtz, M, Heyman, M et al.. Insulin-dependent diabetes: A chronic complication to acute pancreatitis in childhood acute lymphoblastic leukemia. Pediatr Blood Cancer. 2019;66 (1):e27437. doi: 10.1002/pbc.27437. PubMed PMID:30216644 .
  2. Nikkilä, A, Raitanen, J, Lohi, O, Auvinen, A. Radiation exposure from computerized tomography and risk of childhood leukemia: Finnish register-based case-control study of childhood leukemia (FRECCLE). Haematologica. 2018;103 (11):1873-1880. doi: 10.3324/haematol.2018.187716. PubMed PMID:29976736 PubMed Central PMC6278981.
  3. Nikkilä, A, Kendall, G, Raitanen, J, Spycher, B, Lohi, O, Auvinen, A et al.. Effects of incomplete residential histories on studies of environmental exposure with application to childhood leukaemia and background radiation. Environ Res. 2018;166 :466-472. doi: 10.1016/j.envres.2018.06.035. PubMed PMID:29945121 .
  4. Nordfors, K, Haapasalo, J, Afyounian, E, Tuominen, J, Annala, M, Häyrynen, S et al.. Erratum: Whole-exome sequencing identifies germline mutation in TP53 and ATRX in a child with genomically aberrant AT/RT and her mother with anaplastic astrocytoma. Cold Spring Harb Mol Case Stud. 2018;4 (3):. doi: 10.1101/mcs.a003129. PubMed PMID:29858379 PubMed Central PMC5983177.
  5. Nordfors, K, Haapasalo, J, Afyounian, E, Tuominen, J, Annala, M, Häyrynen, S et al.. Whole-exome sequencing identifies germline mutation in TP53 and ATRX in a child with genomically aberrant AT/RT and her mother with anaplastic astrocytoma. Cold Spring Harb Mol Case Stud. 2018;4 (2):. doi: 10.1101/mcs.a002246. PubMed PMID:29602769 PubMed Central PMC5880256.
  6. de Bock, CE, Demeyer, S, Degryse, S, Verbeke, D, Sweron, B, Gielen, O et al.. HOXA9 Cooperates with Activated JAK/STAT Signaling to Drive Leukemia Development. Cancer Discov. 2018;8 (5):616-631. doi: 10.1158/2159-8290.CD-17-0583. PubMed PMID:29496663 .
  7. Norberg, A, Rosén, A, Raaschou-Jensen, K, Kjeldsen, L, Moilanen, JS, Paulsson-Karlsson, Y et al.. Novel variants in Nordic patients referred for genetic testing of telomere-related disorders. Eur J Hum Genet. 2018;26 (6):858-867. doi: 10.1038/s41431-018-0112-8. PubMed PMID:29483670 PubMed Central PMC5974393.

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2017

  1. Teppo, S, Heinäniemi, M, Lohi, O. Deregulation of the non-coding genome in leukemia. RNA Biol. 2017;14 (7):827-830. doi: 10.1080/15476286.2017.1312228. PubMed PMID:28387584 PubMed Central PMC5546539.
  2. Lohi, O, Heinäniemi, M. Derailed regulatory network in childhood acute leukaemia. Acta Paediatr. 2017;106 (3):359-360. doi: 10.1111/apa.13714. PubMed PMID:28186373 .
  3. Grönroos, T, Teppo, S, Mehtonen, J, Laukkanen, S, Liuksiala, T, Nykter, M et al.. Overexpression of PTP4A3 in ETV6-RUNX1 acute lymphoblastic leukemia. Leuk Res. 2017;54 :1-6. doi: 10.1016/j.leukres.2016.12.005. PubMed PMID:28063378 .

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2016

  1. Grönroos, T, Teppo, S, Mehtonen, J, Laukkanen, S, Liuksiala, T, Nykter, M et al.. Overexpression of PTP4A3 in ETV6-RUNX1 acute lymphoblastic leukemia. Leuk Res. 2017;54 :1-6. doi: 10.1016/j.leukres.2016.12.005. PubMed PMID:28063378 .
  2. Teppo, S, Laukkanen, S, Liuksiala, T, Nordlund, J, Oittinen, M, Teittinen, K et al.. Genome-wide repression of eRNA and target gene loci by the ETV6-RUNX1 fusion in acute leukemia. Genome Res. 2016;26 (11):1468-1477. doi: 10.1101/gr.193649.115. PubMed PMID:27620872 PubMed Central PMC5088590.
  3. Heinäniemi, M, Vuorenmaa, T, Teppo, S, Kaikkonen, MU, Bouvy-Liivrand, M, Mehtonen, J et al.. Transcription-coupled genetic instability marks acute lymphoblastic leukemia structural variation hotspots. Elife. 2016;5 :. doi: 10.7554/eLife.13087. PubMed PMID:27431763 PubMed Central PMC4951197.
  4. Nikkilä, A, Erme, S, Arvela, H, Holmgren, O, Raitanen, J, Lohi, O et al.. Background radiation and childhood leukemia: A nationwide register-based case-control study. Int J Cancer. 2016;139 (9):1975-82. doi: 10.1002/ijc.30264. PubMed PMID:27405274 .
  5. Teppo, E, Penttinen, J, Myöhänen, O, Vettenranta, K, Lohi, O. Single-centre study reports a 84% five-year overall survival rate for paediatric solid tumours. Acta Paediatr. 2016;105 (8):952-8. doi: 10.1111/apa.13425. PubMed PMID:27060472 .
  6. Järvelä, L, Raitanen, J, Erme, S, Lohi, O, Auvinen, A. Residential mobility and the risk of childhood leukemia. Cancer Causes Control. 2016;27 (3):433-43. doi: 10.1007/s10552-016-0720-y. PubMed PMID:26830898 .
  7. Lohi, O, Helminen, M, Korppi, M. Audits show that specialist paediatric training programmes are sensitive to medical, staffing and economic changes. Acta Paediatr. 2016;105 (6):701-4. doi: 10.1111/apa.13330. PubMed PMID:26776769 .
  8. Laitaoja, M, Tossavainen, H, Pihlajamaa, T, Valjakka, J, Viiri, K, Lohi, O et al.. Redox-dependent disulfide bond formation in SAP30L corepressor protein: Implications for structure and function. Protein Sci. 2016;25 (3):572-86. doi: 10.1002/pro.2849. PubMed PMID:26609676 PubMed Central PMC4815409.

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