2024 |
2023 |
- Terzioglu, M, Veeroja, K, Montonen, T, Ihalainen, TO, Salminen, TS, Bénit, P et al.. Mitochondrial temperature homeostasis resists external metabolic stresses. Elife. 2023;12 :. doi: 10.7554/eLife.89232. PubMed PMID:38079477 PubMed Central PMC10712956.
- Jacobs, HT. A century of mitochondrial research, 1922-2022. Enzymes. 2023;54 :37-70. doi: 10.1016/bs.enz.2023.07.002. PubMed PMID:37945177 .
- Ikonen, L, Pirnes-Karhu, S, Pradhan, S, Jacobs, HT, Szibor, M, Suomalainen, A et al.. Alternative oxidase causes cell type- and tissue-specific responses in mutator mice. Life Sci Alliance. 2023;6 (11):. doi: 10.26508/lsa.202302036. PubMed PMID:37657934 PubMed Central PMC10474302.
- Jacobs, HT, Szibor, M, Rathkolb, B, da Silva-Buttkus, P, Aguilar-Pimentel, JA, Amarie, OV et al.. AOX delays the onset of the lethal phenotype in a mouse model of Uqcrh (complex III) disease. Biochim Biophys Acta Mol Basis Dis. 2023;1869 (7):166760. doi: 10.1016/j.bbadis.2023.166760. PubMed PMID:37230398 .
- Jacobs, HT, Tuomela, T, Lillsunde, P. Nuclear genetic background influences the phenotype of the Drosophila tko25t mitochondrial protein-synthesis mutant. G3 (Bethesda). 2023;13 (6):. doi: 10.1093/g3journal/jkad078. PubMed PMID:37017029 PubMed Central PMC10234395.
2022 |
- L B Almeida, B, M Bahrudeen, MN, Chauhan, V, Dash, S, Kandavalli, V, Häkkinen, A et al.. The transcription factor network of E. coli steers global responses to shifts in RNAP concentration. Nucleic Acids Res. 2022;50 (12):6801-6819. doi: 10.1093/nar/gkac540. PubMed PMID:35748858 PubMed Central PMC9262627.
- El-Khoury, R, Rak, M, Bénit, P, Jacobs, HT, Rustin, P. Cyanide resistant respiration and the alternative oxidase pathway: A journey from plants to mammals. Biochim Biophys Acta Bioenerg. 2022;1863 (6):148567. doi: 10.1016/j.bbabio.2022.148567. PubMed PMID:35500614 .
- Billingham, LK, Stoolman, JS, Vasan, K, Rodriguez, AE, Poor, TA, Szibor, M et al.. Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation. Nat Immunol. 2022;23 (5):692-704. doi: 10.1038/s41590-022-01185-3. PubMed PMID:35484407 PubMed Central PMC9098388.
- Jacobs, HT, Ballard, JWO. What physiological role(s) does the alternative oxidase perform in animals?. Biochim Biophys Acta Bioenerg. 2022;1863 (6):148556. doi: 10.1016/j.bbabio.2022.148556. PubMed PMID:35367450 .
- Giordano, L, Aneja, MK, Sommer, N, Alebrahimdehkordi, N, Seraji, A, Weissmann, N et al.. Alternative oxidase encoded by sequence-optimized and chemically-modified RNA transfected into mammalian cells is catalytically active. Gene Ther. 2022;29 (12):655-664. doi: 10.1038/s41434-021-00235-z. PubMed PMID:33664504 PubMed Central PMC9750868.
2021 |
- Bremer, K, Yasuo, H, Debes, PV, Jacobs, HT. The alternative oxidase (AOX) increases sulphide tolerance in the highly invasive marine invertebrate Ciona intestinalis. J Exp Biol. 2021;224 (16):. doi: 10.1242/jeb.242985. PubMed PMID:34423818 PubMed Central PMC8407659.
- Giordano, L, Aneja, MK, Sommer, N, Alebrahimdehkordi, N, Seraji, A, Weissmann, N et al.. Alternative oxidase encoded by sequence-optimized and chemically-modified RNA transfected into mammalian cells is catalytically active. Gene Ther. 2022;29 (12):655-664. doi: 10.1038/s41434-021-00235-z. PubMed PMID:33664504 PubMed Central PMC9750868.
2020 |
- Yalgin, C, Rovenko, B, Andjelković, A, Neefjes, M, Oymak, B, Dufour, E et al.. Effects on Dopaminergic Neurons Are Secondary in COX-Deficient Locomotor Dysfunction in Drosophila. iScience. 2020;23 (8):101362. doi: 10.1016/j.isci.2020.101362. PubMed PMID:32738610 PubMed Central PMC7394922.
- González de Cózar, JM, Carretero-Junquera, M, Ciesielski, GL, Miettinen, SM, Varjosalo, M, Kaguni, LS et al.. A second hybrid-binding domain modulates the activity of Drosophila ribonuclease H1. J Biochem. 2020;168 (5):515-533. doi: 10.1093/jb/mvaa067. PubMed PMID:32589740 PubMed Central PMC7657459.
- Sommer, N, Alebrahimdehkordi, N, Pak, O, Knoepp, F, Strielkov, I, Scheibe, S et al.. Bypassing mitochondrial complex III using alternative oxidase inhibits acute pulmonary oxygen sensing. Sci Adv. 2020;6 (16):eaba0694. doi: 10.1126/sciadv.aba0694. PubMed PMID:32426457 PubMed Central PMC7159913.
- Szibor, M, Schreckenberg, R, Gizatullina, Z, Dufour, E, Wiesnet, M, Dhandapani, PK et al.. Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia. J Cell Mol Med. 2020;24 (6):3534-3548. doi: 10.1111/jcmm.15043. PubMed PMID:32040259 PubMed Central PMC7131948.
- Gospodaryov, DV, Strilbytska, OM, Semaniuk, UV, Perkhulyn, NV, Rovenko, BM, Yurkevych, IS et al.. Correction to: Alternative NADH dehydrogenase extends lifespan and increases resistance to xenobiotics in Drosophila. Biogerontology. 2020;21 (2):173-174. doi: 10.1007/s10522-020-09858-y. PubMed PMID:31989363 PubMed Central PMC7056683.
- Jacobs, HT, George, J, Kemppainen, E. Regulation of growth in Drosophila melanogaster: the roles of mitochondrial metabolism. J Biochem. 2020;167 (3):267-277. doi: 10.1093/jb/mvaa002. PubMed PMID:31926002 PubMed Central PMC7048069.
- Gospodaryov, DV, Strilbytska, OM, Semaniuk, UV, Perkhulyn, NV, Rovenko, BM, Yurkevych, IS et al.. Alternative NADH dehydrogenase extends lifespan and increases resistance to xenobiotics in Drosophila. Biogerontology. 2020;21 (2):155-171. doi: 10.1007/s10522-019-09849-8. PubMed PMID:31749111PubMed Central PMC7056681.
2019 |
- Gospodaryov, DV, Strilbytska, OM, Semaniuk, UV, Perkhulyn, NV, Rovenko, BM, Yurkevych, IS et al.. Alternative NADH dehydrogenase extends lifespan and increases resistance to xenobiotics in Drosophila. Biogerontology. 2020;21 (2):155-171. doi: 10.1007/s10522-019-09849-8. PubMed PMID:31749111PubMed Central PMC7056681.
- Bahhir, D, Yalgin, C, Ots, L, Järvinen, S, George, J, Naudí, A et al.. Manipulating mtDNA in vivo reprograms metabolism via novel response mechanisms. PLoS Genet. 2019;15 (10):e1008410. doi: 10.1371/journal.pgen.1008410. PubMed PMID:31584940 PubMed Central PMC6795474.
- George, J, Tuomela, T, Kemppainen, E, Nurminen, A, Braun, S, Yalgin, C et al.. Mitochondrial dysfunction generates a growth-restraining signal linked to pyruvate in Drosophila larvae. Fly (Austin). ;13 (1-4):12-28. doi: 10.1080/19336934.2019.1662266. PubMed PMID:31526131 PubMed Central PMC6988875.
- Dhandapani, PK, Begines-Moreno, IM, Brea-Calvo, G, Gärtner, U, Graeber, TG, Javier Sanchez, G et al.. Hyperoxia but not AOX expression mitigates pathological cardiac remodeling in a mouse model of inflammatory cardiomyopathy. Sci Rep. 2019;9 (1):12741. doi: 10.1038/s41598-019-49231-9. PubMed PMID:31484989 PubMed Central PMC6726756.
- George, J, Jacobs, HT. Germline knockdown of spargel (PGC-1) produces embryonic lethality in Drosophila. Mitochondrion. 2019;49 :189-199. doi: 10.1016/j.mito.2019.08.006. PubMed PMID:31473309 .
- George, J, Jacobs, HT. Minimal effects of spargel (PGC-1) overexpression in a Drosophila mitochondrial disease model. Biol Open. 2019;8 (7):. doi: 10.1242/bio.042135. PubMed PMID:31292108 PubMed Central PMC6679408.
- Dhandapani, PK, Lyyski, AM, Paulin, L, Khan, NA, Suomalainen, A, Auvinen, P et al.. Phenotypic effects of dietary stress in combination with a respiratory chain bypass in mice. Physiol Rep. 2019;7 (13):e14159. doi: 10.14814/phy2.14159. PubMed PMID:31267687 PubMed Central PMC6606514.
- Saari, S, Kemppainen, E, Tuomela, T, Oliveira, MT, Dufour, E, Jacobs, HT et al.. Alternative oxidase confers nutritional limitation on Drosophila development. J Exp Zool A Ecol Integr Physiol. 2019;331 (6):341-356. doi: 10.1002/jez.2274. PubMed PMID:31218852 PubMed Central PMC6617715.
- Salminen, TS, Cannino, G, Oliveira, MT, Lillsunde, P, Jacobs, HT, Kaguni, LS et al.. Lethal Interaction of Nuclear and Mitochondrial Genotypes in Drosophila melanogaster. G3 (Bethesda). 2019;9 (7):2225-2234. doi: 10.1534/g3.119.400315. PubMed PMID:31076384 PubMed Central PMC6643882.
- González de Cózar, JM, Gerards, M, Teeri, E, George, J, Dufour, E, Jacobs, HT et al.. RNase H1 promotes replication fork progression through oppositely transcribed regions of Drosophila mitochondrial DNA. J Biol Chem. 2019;294 (12):4331-4344. doi: 10.1074/jbc.RA118.007015. PubMed PMID:30635398PubMed Central PMC6433063.
- Rajendran, J, Purhonen, J, Tegelberg, S, Smolander, OP, Mörgelin, M, Rozman, J et al.. Alternative oxidase-mediated respiration prevents lethal mitochondrial cardiomyopathy. EMBO Mol Med. 2019;11 (1):. doi: 10.15252/emmm.201809456. PubMed PMID:30530468 PubMed Central PMC6328925.
- Saari, S, Garcia, GS, Bremer, K, Chioda, MM, Andjelković, A, Debes, PV et al.. Alternative respiratory chain enzymes: Therapeutic potential and possible pitfalls. Biochim Biophys Acta Mol Basis Dis. 2019;1865 (4):854-866. doi: 10.1016/j.bbadis.2018.10.012. PubMed PMID:30342157 .
- Giordano, L, Farnham, A, Dhandapani, PK, Salminen, L, Bhaskaran, J, Voswinckel, R et al.. Alternative Oxidase Attenuates Cigarette Smoke-induced Lung Dysfunction and Tissue Damage. Am J Respir Cell Mol Biol. 2019;60 (5):515-522. doi: 10.1165/rcmb.2018-0261OC. PubMed PMID:30339461PubMed Central PMC6503618.
2018 |
- Saari, S, Garcia, GS, Bremer, K, Chioda, MM, Andjelković, A, Debes, PV et al.. Alternative respiratory chain enzymes: Therapeutic potential and possible pitfalls. Biochim Biophys Acta Mol Basis Dis. 2019;1865 (4):854-866. doi: 10.1016/j.bbadis.2018.10.012. PubMed PMID:30342157 .
- Andjelković, A, Mordas, A, Bruinsma, L, Ketola, A, Cannino, G, Giordano, L et al.. Expression of the Alternative Oxidase Influences Jun N-Terminal Kinase Signaling and Cell Migration. Mol Cell Biol. 2018;38 (24):. doi: 10.1128/MCB.00110-18. PubMed PMID:30224521 PubMed Central PMC6275184.
- Dogan, SA, Cerutti, R, Benincá, C, Brea-Calvo, G, Jacobs, HT, Zeviani, M et al.. Perturbed Redox Signaling Exacerbates a Mitochondrial Myopathy. Cell Metab. 2018;28 (5):764-775.e5. doi: 10.1016/j.cmet.2018.07.012. PubMed PMID:30122554 PubMed Central PMC6224544.
- Rodrigues, APC, Camargo, AF, Andjelković, A, Jacobs, HT, Oliveira, MT. Developmental arrest in Drosophila melanogaster caused by mitochondrial DNA replication defects cannot be rescued by the alternative oxidase. Sci Rep. 2018;8 (1):10882. doi: 10.1038/s41598-018-29150-x. PubMed PMID:30022066PubMed Central PMC6052043.
- Toompuu, M, Tuomela, T, Laine, P, Paulin, L, Dufour, E, Jacobs, HT et al.. Polyadenylation and degradation of structurally abnormal mitochondrial tRNAs in human cells. Nucleic Acids Res. 2018;46 (10):5209-5226. doi: 10.1093/nar/gky159. PubMed PMID:29518244 PubMed Central PMC6007314.
- Ciesielski, GL, Nadalutti, CA, Oliveira, MT, Jacobs, HT, Griffith, JD, Kaguni, LS et al.. Structural rearrangements in the mitochondrial genome of Drosophila melanogaster induced by elevated levels of the replicative DNA helicase. Nucleic Acids Res. 2018;46 (6):3034-3046. doi: 10.1093/nar/gky094. PubMed PMID:29432582 PubMed Central PMC5887560.
- Camargo, AF, Chioda, MM, Rodrigues, APC, Garcia, GS, McKinney, EA, Jacobs, HT et al.. Xenotopic expression of alternative electron transport enzymes in animal mitochondria and their impact in health and disease. Cell Biol Int. 2018;42 (6):664-669. doi: 10.1002/cbin.10943. PubMed PMID:29384231 .
- Chrétien, D, Bénit, P, Ha, HH, Keipert, S, El-Khoury, R, Chang, YT et al.. Mitochondria are physiologically maintained at close to 50 °C. PLoS Biol. 2018;16 (1):e2003992. doi: 10.1371/journal.pbio.2003992. PubMed PMID:29370167 PubMed Central PMC5784887.
- Gerards, M, Cannino, G, González de Cózar, JM, Jacobs, HT. Intracellular vesicle trafficking plays an essential role in mitochondrial quality control. Mol Biol Cell. 2018;29 (7):809-819. doi: 10.1091/mbc.E17-10-0619. PubMed PMID:29343549 PubMed Central PMC5905294.
2017 |
- Saari, S, Andjelković, A, Garcia, GS, Jacobs, HT, Oliveira, MT. Expression of Ciona intestinalis AOX causes male reproductive defects in Drosophila melanogaster. BMC Dev Biol. 2017;17 (1):9. doi: 10.1186/s12861-017-0151-3. PubMed PMID:28673232 PubMed Central PMC5496232.
- Salminen, TS, Oliveira, MT, Cannino, G, Lillsunde, P, Jacobs, HT, Kaguni, LS et al.. Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila. Mitochondrion. 2017;34 :75-83. doi: 10.1016/j.mito.2017.02.001. PubMed PMID:28214560 .
- Szibor, M, Dhandapani, PK, Dufour, E, Holmström, KM, Zhuang, Y, Salwig, I et al.. Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology. Dis Model Mech. 2017;10 (2):163-171. doi: 10.1242/dmm.027839. PubMed PMID:28067626 PubMed Central PMC5312010.
2016 |
- Szibor, M, Dhandapani, PK, Dufour, E, Holmström, KM, Zhuang, Y, Salwig, I et al.. Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology. Dis Model Mech. 2017;10 (2):163-171. doi: 10.1242/dmm.027839. PubMed PMID:28067626 PubMed Central PMC5312010.
- Mills, EL, Kelly, B, Logan, A, Costa, ASH, Varma, M, Bryant, CE et al.. Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages. Cell. 2016;167 (2):457-470.e13. doi: 10.1016/j.cell.2016.08.064. PubMed PMID:27667687 PubMed Central PMC5863951.
- Andjelković, A, Kemppainen, KK, Jacobs, HT. Ligand-Bound GeneSwitch Causes Developmental Aberrations in Drosophila that Are Alleviated by the Alternative Oxidase. G3 (Bethesda). 2016;6 (9):2839-46. doi: 10.1534/g3.116.030882. PubMed PMID:27412986 PubMed Central PMC5015941.
- Shi, Y, Posse, V, Zhu, X, Hyvärinen, AK, Jacobs, HT, Falkenberg, M et al.. Mitochondrial transcription termination factor 1 directs polar replication fork pausing. Nucleic Acids Res. 2016;44 (12):5732-42. doi: 10.1093/nar/gkw302. PubMed PMID:27112570 PubMed Central PMC4937320.
- El-Khoury, R, Kaulio, E, Lassila, KA, Crowther, DC, Jacobs, HT, Rustin, P et al.. Expression of the alternative oxidase mitigates beta-amyloid production and toxicity in model systems. Free Radic Biol Med. 2016;96 :57-66. doi: 10.1016/j.freeradbiomed.2016.04.006. PubMed PMID:27094492 .
- Kemppainen, E, George, J, Garipler, G, Tuomela, T, Kiviranta, E, Soga, T et al.. Correction: Mitochondrial Dysfunction Plus High-Sugar Diet Provokes a Metabolic Crisis That Inhibits Growth. PLoS One. 2016;11 (3):e0151421. doi: 10.1371/journal.pone.0151421. PubMed PMID:26954062 PubMed Central PMC4783076.
- Kemppainen, E, George, J, Garipler, G, Tuomela, T, Kiviranta, E, Soga, T et al.. Mitochondrial Dysfunction Plus High-Sugar Diet Provokes a Metabolic Crisis That Inhibits Growth. PLoS One. 2016;11 (1):e0145836. doi: 10.1371/journal.pone.0145836. PubMed PMID:26812173 PubMed Central PMC4728084.
2015 |
- Andjelković, A, Oliveira, MT, Cannino, G, Yalgin, C, Dhandapani, PK, Dufour, E et al.. Diiron centre mutations in Ciona intestinalis alternative oxidase abolish enzymatic activity and prevent rescue of cytochrome oxidase deficiency in flies. Sci Rep. 2015;5 :18295. doi: 10.1038/srep18295. PubMed PMID:26672986PubMed Central PMC4682143.
- Syrjänen, L, Valanne, S, Kuuslahti, M, Tuomela, T, Sriram, A, Sanz, A et al.. β carbonic anhydrase is required for female fertility in Drosophila melanogaster. Front Zool. 2015;12 :19. doi: 10.1186/s12983-015-0111-3. PubMed PMID:26300950 PubMed Central PMC4546311.
- Holmes, JB, Akman, G, Wood, SR, Sakhuja, K, Cerritelli, SM, Moss, C et al.. Primer retention owing to the absence of RNase H1 is catastrophic for mitochondrial DNA replication. Proc Natl Acad Sci U S A. 2015;112 (30):9334-9. doi: 10.1073/pnas.1503653112. PubMed PMID:26162680 PubMed Central PMC4522766.
- Lewis, SC, Joers, P, Willcox, S, Griffith, JD, Jacobs, HT, Hyman, BC et al.. A rolling circle replication mechanism produces multimeric lariats of mitochondrial DNA in Caenorhabditis elegans. PLoS Genet. 2015;11 (2):e1004985. doi: 10.1371/journal.pgen.1004985. PubMed PMID:25693201 PubMed Central PMC4334201.
2014 |
- Holt, IJ, Jacobs, HT. Unique features of DNA replication in mitochondria: a functional and evolutionary perspective. Bioessays. 2014;36 (11):1024-31. doi: 10.1002/bies.201400052. PubMed PMID:25220172 .
- Kemppainen, KK, Kemppainen, E, Jacobs, HT. The alternative oxidase AOX does not rescue the phenotype of tko25t mutant flies. G3 (Bethesda). 2014;4 (10):2013-21. doi: 10.1534/g3.114.013946. PubMed PMID:25147191 PubMed Central PMC4199707.
- Gospodaryov, DV, Lushchak, OV, Rovenko, BM, Perkhulyn, NV, Gerards, M, Tuomela, T et al.. Ciona intestinalis NADH dehydrogenase NDX confers stress-resistance and extended lifespan on Drosophila. Biochim Biophys Acta. 2014;1837 (11):1861-1869. doi: 10.1016/j.bbabio.2014.08.001. PubMed PMID:25124484 .
- Fukuoh, A, Cannino, G, Gerards, M, Buckley, S, Kazancioglu, S, Scialo, F et al.. Screen for mitochondrial DNA copy number maintenance genes reveals essential role for ATP synthase. Mol Syst Biol. 2014;10 :734. doi: 10.15252/msb.20145117. PubMed PMID:24952591 PubMed Central PMC4265055.
- Vartiainen, S, Chen, S, George, J, Tuomela, T, Luoto, KR, O’Dell, KM et al.. Phenotypic rescue of a Drosophila model of mitochondrial ANT1 disease. Dis Model Mech. 2014;7 (6):635-48. doi: 10.1242/dmm.016527. PubMed PMID:24812436 PubMed Central PMC4036471.
- El-Khoury, R, Kemppainen, KK, Dufour, E, Szibor, M, Jacobs, HT, Rustin, P et al.. Engineering the alternative oxidase gene to better understand and counteract mitochondrial defects: state of the art and perspectives. Br J Pharmacol. 2014;171 (8):2243-9. doi: 10.1111/bph.12570. PubMed PMID:24383965PubMed Central PMC3976633.
- Kemppainen, KK, Rinne, J, Sriram, A, Lakanmaa, M, Zeb, A, Tuomela, T et al.. Expression of alternative oxidase in Drosophila ameliorates diverse phenotypes due to cytochrome oxidase deficiency. Hum Mol Genet. 2014;23 (8):2078-93. doi: 10.1093/hmg/ddt601. PubMed PMID:24293544 PubMed Central PMC3959817.
2013 |
- Kemppainen, KK, Rinne, J, Sriram, A, Lakanmaa, M, Zeb, A, Tuomela, T et al.. Expression of alternative oxidase in Drosophila ameliorates diverse phenotypes due to cytochrome oxidase deficiency. Hum Mol Genet. 2014;23 (8):2078-93. doi: 10.1093/hmg/ddt601. PubMed PMID:24293544 PubMed Central PMC3959817.
- Jõers, P, Lewis, SC, Fukuoh, A, Parhiala, M, Ellilä, S, Holt, IJ et al.. Mitochondrial transcription terminator family members mTTF and mTerf5 have opposing roles in coordination of mtDNA synthesis. PLoS Genet. 2013;9 (9):e1003800. doi: 10.1371/journal.pgen.1003800. PubMed PMID:24068965 PubMed Central PMC3778013.
- Reyes, A, Kazak, L, Wood, SR, Yasukawa, T, Jacobs, HT, Holt, IJ et al.. Mitochondrial DNA replication proceeds via a ‘bootlace’ mechanism involving the incorporation of processed transcripts. Nucleic Acids Res. 2013;41 (11):5837-50. doi: 10.1093/nar/gkt196. PubMed PMID:23595151 PubMed Central PMC3675460.
- Hershey, AD, Powers, SW, Coffey, CS, Eklund, DD, Chamberlin, LA, Korbee, LL et al.. Childhood and Adolescent Migraine Prevention (CHAMP) study: a double-blinded, placebo-controlled, comparative effectiveness study of amitriptyline, topiramate, and placebo in the prevention of childhood and adolescent migraine. Headache. 2013;53 (5):799-816. doi: 10.1111/head.12105. PubMed PMID:23594025 PubMed Central PMC3637406.
- Richter, U, Lahtinen, T, Marttinen, P, Myöhänen, M, Greco, D, Cannino, G et al.. A mitochondrial ribosomal and RNA decay pathway blocks cell proliferation. Curr Biol. 2013;23 (6):535-41. doi: 10.1016/j.cub.2013.02.019. PubMed PMID:23453957 .
- Jõers, P, Jacobs, HT. Analysis of replication intermediates indicates that Drosophila melanogaster mitochondrial DNA replicates by a strand-coupled theta mechanism. PLoS One. 2013;8 (1):e53249. doi: 10.1371/journal.pone.0053249. PubMed PMID:23308172 PubMed Central PMC3537619.
- El-Khoury, R, Dufour, E, Rak, M, Ramanantsoa, N, Grandchamp, N, Csaba, Z et al.. Alternative oxidase expression in the mouse enables bypassing cytochrome c oxidase blockade and limits mitochondrial ROS overproduction. PLoS Genet. 2013;9 (1):e1003182. doi: 10.1371/journal.pgen.1003182. PubMed PMID:23300486 PubMed Central PMC3536694.
2012 |
- Cannino, G, El-Khoury, R, Pirinen, M, Hutz, B, Rustin, P, Jacobs, HT et al.. Glucose modulates respiratory complex I activity in response to acute mitochondrial dysfunction. J Biol Chem. 2012;287 (46):38729-40. doi: 10.1074/jbc.M112.386060. PubMed PMID:23007390 PubMed Central PMC3493916.
- Stefanatos, R, Sriram, A, Kiviranta, E, Mohan, A, Ayala, V, Jacobs, HT et al.. dj-1β regulates oxidative stress, insulin-like signaling and development in Drosophila melanogaster. Cell Cycle. 2012;11 (20):3876-86. doi: 10.4161/cc.22073. PubMed PMID:22983063 PubMed Central PMC3495829.
- Chen, S, Oliveira, MT, Sanz, A, Kemppainen, E, Fukuoh, A, Schlicht, B et al.. A cytoplasmic suppressor of a nuclear mutation affecting mitochondrial functions in Drosophila. Genetics. 2012;192 (2):483-93. doi: 10.1534/genetics.112.143719. PubMed PMID:22851652 PubMed Central PMC3454878.
- Schiff, M, Bénit, P, Jacobs, HT, Vockley, J, Rustin, P. Therapies in inborn errors of oxidative metabolism. Trends Endocrinol Metab. 2012;23 (9):488-95. doi: 10.1016/j.tem.2012.04.006. PubMed PMID:22633959 PubMed Central PMC4135311.
- Humphrey, DM, Parsons, RB, Ludlow, ZN, Riemensperger, T, Esposito, G, Verstreken, P et al.. Alternative oxidase rescues mitochondria-mediated dopaminergic cell loss in Drosophila. Hum Mol Genet. 2012;21 (12):2698-712. doi: 10.1093/hmg/dds096. PubMed PMID:22398207 .