Publications

2021

  1. Bremer, K, Yasuo, H, Debes, PV, Jacobs, HT. The alternative oxidase (AOX) increases sulphide tolerance in the highly invasive marine invertebrate Ciona intestinalis. J Exp Biol. 2021;224 (16):. doi: 10.1242/jeb.242985. PubMed PMID:34423818 PubMed Central PMC8407659.
  2. Giordano, L, Aneja, MK, Sommer, N, Alebrahimdehkordi, N, Seraji, A, Weissmann, N et al.. Alternative oxidase encoded by sequence-optimized and chemically-modified RNA transfected into mammalian cells is catalytically active. Gene Ther. 2021; :. doi: 10.1038/s41434-021-00235-z. PubMed PMID:33664504 .

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2020

  1. Yalgin, C, Rovenko, B, Andjelković, A, Neefjes, M, Oymak, B, Dufour, E et al.. Effects on Dopaminergic Neurons Are Secondary in COX-Deficient Locomotor Dysfunction in Drosophila. iScience. 2020;23 (8):101362. doi: 10.1016/j.isci.2020.101362. PubMed PMID:32738610 PubMed Central PMC7394922.
  2. González de Cózar, JM, Carretero-Junquera, M, Ciesielski, GL, Miettinen, SM, Varjosalo, M, Kaguni, LS et al.. A second hybrid-binding domain modulates the activity of Drosophila ribonuclease H1. J Biochem. 2020;168 (5):515-533. doi: 10.1093/jb/mvaa067. PubMed PMID:32589740 PubMed Central PMC7657459.
  3. Sommer, N, Alebrahimdehkordi, N, Pak, O, Knoepp, F, Strielkov, I, Scheibe, S et al.. Bypassing mitochondrial complex III using alternative oxidase inhibits acute pulmonary oxygen sensing. Sci Adv. 2020;6 (16):eaba0694. doi: 10.1126/sciadv.aba0694. PubMed PMID:32426457 PubMed Central PMC7159913.
  4. Szibor, M, Schreckenberg, R, Gizatullina, Z, Dufour, E, Wiesnet, M, Dhandapani, PK et al.. Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia. J Cell Mol Med. 2020;24 (6):3534-3548. doi: 10.1111/jcmm.15043. PubMed PMID:32040259 PubMed Central PMC7131948.
  5. Gospodaryov, DV, Strilbytska, OM, Semaniuk, UV, Perkhulyn, NV, Rovenko, BM, Yurkevych, IS et al.. Correction to: Alternative NADH dehydrogenase extends lifespan and increases resistance to xenobiotics in Drosophila. Biogerontology. 2020;21 (2):173-174. doi: 10.1007/s10522-020-09858-y. PubMed PMID:31989363 PubMed Central PMC7056683.
  6. Jacobs, HT, George, J, Kemppainen, E. Regulation of growth in Drosophila melanogaster: the roles of mitochondrial metabolism. J Biochem. 2020;167 (3):267-277. doi: 10.1093/jb/mvaa002. PubMed PMID:31926002 PubMed Central PMC7048069.
  7. Gospodaryov, DV, Strilbytska, OM, Semaniuk, UV, Perkhulyn, NV, Rovenko, BM, Yurkevych, IS et al.. Alternative NADH dehydrogenase extends lifespan and increases resistance to xenobiotics in Drosophila. Biogerontology. 2020;21 (2):155-171. doi: 10.1007/s10522-019-09849-8. PubMed PMID:31749111 PubMed Central PMC7056681.

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2019

  1. Gospodaryov, DV, Strilbytska, OM, Semaniuk, UV, Perkhulyn, NV, Rovenko, BM, Yurkevych, IS et al.. Alternative NADH dehydrogenase extends lifespan and increases resistance to xenobiotics in Drosophila. Biogerontology. 2020;21 (2):155-171. doi: 10.1007/s10522-019-09849-8. PubMed PMID:31749111PubMed Central PMC7056681.
  2. Bahhir, D, Yalgin, C, Ots, L, Järvinen, S, George, J, Naudí, A et al.. Manipulating mtDNA in vivo reprograms metabolism via novel response mechanisms. PLoS Genet. 2019;15 (10):e1008410. doi: 10.1371/journal.pgen.1008410. PubMed PMID:31584940 PubMed Central PMC6795474.
  3. George, J, Tuomela, T, Kemppainen, E, Nurminen, A, Braun, S, Yalgin, C et al.. Mitochondrial dysfunction generates a growth-restraining signal linked to pyruvate in Drosophila larvae. Fly (Austin). ;13 (1-4):12-28. doi: 10.1080/19336934.2019.1662266. PubMed PMID:31526131 PubMed Central PMC6988875.
  4. Dhandapani, PK, Begines-Moreno, IM, Brea-Calvo, G, Gärtner, U, Graeber, TG, Javier Sanchez, G et al.. Hyperoxia but not AOX expression mitigates pathological cardiac remodeling in a mouse model of inflammatory cardiomyopathy. Sci Rep. 2019;9 (1):12741. doi: 10.1038/s41598-019-49231-9. PubMed PMID:31484989 PubMed Central PMC6726756.
  5. George, J, Jacobs, HT. Germline knockdown of spargel (PGC-1) produces embryonic lethality in Drosophila. Mitochondrion. 2019;49 :189-199. doi: 10.1016/j.mito.2019.08.006. PubMed PMID:31473309 .
  6. George, J, Jacobs, HT. Minimal effects of spargel (PGC-1) overexpression in a Drosophila mitochondrial disease model. Biol Open. 2019;8 (7):. doi: 10.1242/bio.042135. PubMed PMID:31292108 PubMed Central PMC6679408.
  7. Dhandapani, PK, Lyyski, AM, Paulin, L, Khan, NA, Suomalainen, A, Auvinen, P et al.. Phenotypic effects of dietary stress in combination with a respiratory chain bypass in mice. Physiol Rep. 2019;7 (13):e14159. doi: 10.14814/phy2.14159. PubMed PMID:31267687 PubMed Central PMC6606514.
  8. Saari, S, Kemppainen, E, Tuomela, T, Oliveira, MT, Dufour, E, Jacobs, HT et al.. Alternative oxidase confers nutritional limitation on Drosophila development. J Exp Zool A Ecol Integr Physiol. 2019;331 (6):341-356. doi: 10.1002/jez.2274. PubMed PMID:31218852 PubMed Central PMC6617715.
  9. Salminen, TS, Cannino, G, Oliveira, MT, Lillsunde, P, Jacobs, HT, Kaguni, LS et al.. Lethal Interaction of Nuclear and Mitochondrial Genotypes in Drosophila melanogaster. G3 (Bethesda). 2019;9 (7):2225-2234. doi: 10.1534/g3.119.400315. PubMed PMID:31076384 PubMed Central PMC6643882.
  10. González de Cózar, JM, Gerards, M, Teeri, E, George, J, Dufour, E, Jacobs, HT et al.. RNase H1 promotes replication fork progression through oppositely transcribed regions of Drosophila mitochondrial DNA. J Biol Chem. 2019;294 (12):4331-4344. doi: 10.1074/jbc.RA118.007015. PubMed PMID:30635398PubMed Central PMC6433063.
  11. Rajendran, J, Purhonen, J, Tegelberg, S, Smolander, OP, Mörgelin, M, Rozman, J et al.. Alternative oxidase-mediated respiration prevents lethal mitochondrial cardiomyopathy. EMBO Mol Med. 2019;11 (1):. doi: 10.15252/emmm.201809456. PubMed PMID:30530468 PubMed Central PMC6328925.
  12. Saari, S, Garcia, GS, Bremer, K, Chioda, MM, Andjelković, A, Debes, PV et al.. Alternative respiratory chain enzymes: Therapeutic potential and possible pitfalls. Biochim Biophys Acta Mol Basis Dis. 2019;1865 (4):854-866. doi: 10.1016/j.bbadis.2018.10.012. PubMed PMID:30342157 .
  13. Giordano, L, Farnham, A, Dhandapani, PK, Salminen, L, Bhaskaran, J, Voswinckel, R et al.. Alternative Oxidase Attenuates Cigarette Smoke-induced Lung Dysfunction and Tissue Damage. Am J Respir Cell Mol Biol. 2019;60 (5):515-522. doi: 10.1165/rcmb.2018-0261OC. PubMed PMID:30339461PubMed Central PMC6503618.

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2018

  1. Saari, S, Garcia, GS, Bremer, K, Chioda, MM, Andjelković, A, Debes, PV et al.. Alternative respiratory chain enzymes: Therapeutic potential and possible pitfalls. Biochim Biophys Acta Mol Basis Dis. 2019;1865 (4):854-866. doi: 10.1016/j.bbadis.2018.10.012. PubMed PMID:30342157 .
  2. Andjelković, A, Mordas, A, Bruinsma, L, Ketola, A, Cannino, G, Giordano, L et al.. Expression of the Alternative Oxidase Influences Jun N-Terminal Kinase Signaling and Cell Migration. Mol Cell Biol. 2018;38 (24):. doi: 10.1128/MCB.00110-18. PubMed PMID:30224521 PubMed Central PMC6275184.
  3. Dogan, SA, Cerutti, R, Benincá, C, Brea-Calvo, G, Jacobs, HT, Zeviani, M et al.. Perturbed Redox Signaling Exacerbates a Mitochondrial Myopathy. Cell Metab. 2018;28 (5):764-775.e5. doi: 10.1016/j.cmet.2018.07.012. PubMed PMID:30122554 PubMed Central PMC6224544.
  4. Rodrigues, APC, Camargo, AF, Andjelković, A, Jacobs, HT, Oliveira, MT. Developmental arrest in Drosophila melanogaster caused by mitochondrial DNA replication defects cannot be rescued by the alternative oxidase. Sci Rep. 2018;8 (1):10882. doi: 10.1038/s41598-018-29150-x. PubMed PMID:30022066 PubMed Central PMC6052043.
  5. Toompuu, M, Tuomela, T, Laine, P, Paulin, L, Dufour, E, Jacobs, HT et al.. Polyadenylation and degradation of structurally abnormal mitochondrial tRNAs in human cells. Nucleic Acids Res. 2018;46 (10):5209-5226. doi: 10.1093/nar/gky159. PubMed PMID:29518244 PubMed Central PMC6007314.
  6. Ciesielski, GL, Nadalutti, CA, Oliveira, MT, Jacobs, HT, Griffith, JD, Kaguni, LS et al.. Structural rearrangements in the mitochondrial genome of Drosophila melanogaster induced by elevated levels of the replicative DNA helicase. Nucleic Acids Res. 2018;46 (6):3034-3046. doi: 10.1093/nar/gky094. PubMed PMID:29432582 PubMed Central PMC5887560.
  7. Camargo, AF, Chioda, MM, Rodrigues, APC, Garcia, GS, McKinney, EA, Jacobs, HT et al.. Xenotopic expression of alternative electron transport enzymes in animal mitochondria and their impact in health and disease. Cell Biol Int. 2018;42 (6):664-669. doi: 10.1002/cbin.10943. PubMed PMID:29384231 .
  8. Chrétien, D, Bénit, P, Ha, HH, Keipert, S, El-Khoury, R, Chang, YT et al.. Mitochondria are physiologically maintained at close to 50 °C. PLoS Biol. 2018;16 (1):e2003992. doi: 10.1371/journal.pbio.2003992. PubMed PMID:29370167 PubMed Central PMC5784887.
  9. Gerards, M, Cannino, G, González de Cózar, JM, Jacobs, HT. Intracellular vesicle trafficking plays an essential role in mitochondrial quality control. Mol Biol Cell. 2018;29 (7):809-819. doi: 10.1091/mbc.E17-10-0619. PubMed PMID:29343549 PubMed Central PMC5905294.

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2017

  1. Saari, S, Andjelković, A, Garcia, GS, Jacobs, HT, Oliveira, MT. Expression of Ciona intestinalis AOX causes male reproductive defects in Drosophila melanogaster. BMC Dev Biol. 2017;17 (1):9. doi: 10.1186/s12861-017-0151-3. PubMed PMID:28673232 PubMed Central PMC5496232.
  2. Salminen, TS, Oliveira, MT, Cannino, G, Lillsunde, P, Jacobs, HT, Kaguni, LS et al.. Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila. Mitochondrion. 2017;34 :75-83. doi: 10.1016/j.mito.2017.02.001. PubMed PMID:28214560 .
  3. Szibor, M, Dhandapani, PK, Dufour, E, Holmström, KM, Zhuang, Y, Salwig, I et al.. Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology. Dis Model Mech. 2017;10 (2):163-171. doi: 10.1242/dmm.027839. PubMed PMID:28067626 PubMed Central PMC5312010.

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2016

  1. Szibor, M, Dhandapani, PK, Dufour, E, Holmström, KM, Zhuang, Y, Salwig, I et al.. Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology. Dis Model Mech. 2017;10 (2):163-171. doi: 10.1242/dmm.027839. PubMed PMID:28067626 PubMed Central PMC5312010.
  2. Mills, EL, Kelly, B, Logan, A, Costa, ASH, Varma, M, Bryant, CE et al.. Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages. Cell. 2016;167 (2):457-470.e13. doi: 10.1016/j.cell.2016.08.064. PubMed PMID:27667687 PubMed Central PMC5863951.
  3. Andjelković, A, Kemppainen, KK, Jacobs, HT. Ligand-Bound GeneSwitch Causes Developmental Aberrations in Drosophila that Are Alleviated by the Alternative Oxidase. G3 (Bethesda). 2016;6 (9):2839-46. doi: 10.1534/g3.116.030882. PubMed PMID:27412986 PubMed Central PMC5015941.
  4. Shi, Y, Posse, V, Zhu, X, Hyvärinen, AK, Jacobs, HT, Falkenberg, M et al.. Mitochondrial transcription termination factor 1 directs polar replication fork pausing. Nucleic Acids Res. 2016;44 (12):5732-42. doi: 10.1093/nar/gkw302. PubMed PMID:27112570 PubMed Central PMC4937320.
  5. El-Khoury, R, Kaulio, E, Lassila, KA, Crowther, DC, Jacobs, HT, Rustin, P et al.. Expression of the alternative oxidase mitigates beta-amyloid production and toxicity in model systems. Free Radic Biol Med. 2016;96 :57-66. doi: 10.1016/j.freeradbiomed.2016.04.006. PubMed PMID:27094492 .
  6. Kemppainen, E, George, J, Garipler, G, Tuomela, T, Kiviranta, E, Soga, T et al.. Correction: Mitochondrial Dysfunction Plus High-Sugar Diet Provokes a Metabolic Crisis That Inhibits Growth. PLoS One. 2016;11 (3):e0151421. doi: 10.1371/journal.pone.0151421. PubMed PMID:26954062 PubMed Central PMC4783076.
  7. Kemppainen, E, George, J, Garipler, G, Tuomela, T, Kiviranta, E, Soga, T et al.. Mitochondrial Dysfunction Plus High-Sugar Diet Provokes a Metabolic Crisis That Inhibits Growth. PLoS One. 2016;11 (1):e0145836. doi: 10.1371/journal.pone.0145836. PubMed PMID:26812173 PubMed Central PMC4728084.

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2015

  1. Andjelković, A, Oliveira, MT, Cannino, G, Yalgin, C, Dhandapani, PK, Dufour, E et al.. Diiron centre mutations in Ciona intestinalis alternative oxidase abolish enzymatic activity and prevent rescue of cytochrome oxidase deficiency in flies. Sci Rep. 2015;5 :18295. doi: 10.1038/srep18295. PubMed PMID:26672986PubMed Central PMC4682143.
  2. Syrjänen, L, Valanne, S, Kuuslahti, M, Tuomela, T, Sriram, A, Sanz, A et al.. β carbonic anhydrase is required for female fertility in Drosophila melanogaster. Front Zool. 2015;12 :19. doi: 10.1186/s12983-015-0111-3. PubMed PMID:26300950 PubMed Central PMC4546311.
  3. Holmes, JB, Akman, G, Wood, SR, Sakhuja, K, Cerritelli, SM, Moss, C et al.. Primer retention owing to the absence of RNase H1 is catastrophic for mitochondrial DNA replication. Proc Natl Acad Sci U S A. 2015;112 (30):9334-9. doi: 10.1073/pnas.1503653112. PubMed PMID:26162680 PubMed Central PMC4522766.
  4. Lewis, SC, Joers, P, Willcox, S, Griffith, JD, Jacobs, HT, Hyman, BC et al.. A rolling circle replication mechanism produces multimeric lariats of mitochondrial DNA in Caenorhabditis elegans. PLoS Genet. 2015;11 (2):e1004985. doi: 10.1371/journal.pgen.1004985. PubMed PMID:25693201 PubMed Central PMC4334201.

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2014

  1. Holt, IJ, Jacobs, HT. Unique features of DNA replication in mitochondria: a functional and evolutionary perspective. Bioessays. 2014;36 (11):1024-31. doi: 10.1002/bies.201400052. PubMed PMID:25220172 .
  2. Kemppainen, KK, Kemppainen, E, Jacobs, HT. The alternative oxidase AOX does not rescue the phenotype of tko25t mutant flies. G3 (Bethesda). 2014;4 (10):2013-21. doi: 10.1534/g3.114.013946. PubMed PMID:25147191 PubMed Central PMC4199707.
  3. Gospodaryov, DV, Lushchak, OV, Rovenko, BM, Perkhulyn, NV, Gerards, M, Tuomela, T et al.. Ciona intestinalis NADH dehydrogenase NDX confers stress-resistance and extended lifespan on Drosophila. Biochim Biophys Acta. 2014;1837 (11):1861-1869. doi: 10.1016/j.bbabio.2014.08.001. PubMed PMID:25124484 .
  4. Fukuoh, A, Cannino, G, Gerards, M, Buckley, S, Kazancioglu, S, Scialo, F et al.. Screen for mitochondrial DNA copy number maintenance genes reveals essential role for ATP synthase. Mol Syst Biol. 2014;10 :734. doi: 10.15252/msb.20145117. PubMed PMID:24952591 PubMed Central PMC4265055.
  5. Vartiainen, S, Chen, S, George, J, Tuomela, T, Luoto, KR, O’Dell, KM et al.. Phenotypic rescue of a Drosophila model of mitochondrial ANT1 disease. Dis Model Mech. 2014;7 (6):635-48. doi: 10.1242/dmm.016527. PubMed PMID:24812436 PubMed Central PMC4036471.
  6. El-Khoury, R, Kemppainen, KK, Dufour, E, Szibor, M, Jacobs, HT, Rustin, P et al.. Engineering the alternative oxidase gene to better understand and counteract mitochondrial defects: state of the art and perspectives. Br J Pharmacol. 2014;171 (8):2243-9. doi: 10.1111/bph.12570. PubMed PMID:24383965PubMed Central PMC3976633.
  7. Kemppainen, KK, Rinne, J, Sriram, A, Lakanmaa, M, Zeb, A, Tuomela, T et al.. Expression of alternative oxidase in Drosophila ameliorates diverse phenotypes due to cytochrome oxidase deficiency. Hum Mol Genet. 2014;23 (8):2078-93. doi: 10.1093/hmg/ddt601. PubMed PMID:24293544 PubMed Central PMC3959817.

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2013

  1. Kemppainen, KK, Rinne, J, Sriram, A, Lakanmaa, M, Zeb, A, Tuomela, T et al.. Expression of alternative oxidase in Drosophila ameliorates diverse phenotypes due to cytochrome oxidase deficiency. Hum Mol Genet. 2014;23 (8):2078-93. doi: 10.1093/hmg/ddt601. PubMed PMID:24293544 PubMed Central PMC3959817.
  2. Jõers, P, Lewis, SC, Fukuoh, A, Parhiala, M, Ellilä, S, Holt, IJ et al.. Mitochondrial transcription terminator family members mTTF and mTerf5 have opposing roles in coordination of mtDNA synthesis. PLoS Genet. 2013;9 (9):e1003800. doi: 10.1371/journal.pgen.1003800. PubMed PMID:24068965 PubMed Central PMC3778013.
  3. Reyes, A, Kazak, L, Wood, SR, Yasukawa, T, Jacobs, HT, Holt, IJ et al.. Mitochondrial DNA replication proceeds via a ‘bootlace’ mechanism involving the incorporation of processed transcripts. Nucleic Acids Res. 2013;41 (11):5837-50. doi: 10.1093/nar/gkt196. PubMed PMID:23595151 PubMed Central PMC3675460.
  4. Hershey, AD, Powers, SW, Coffey, CS, Eklund, DD, Chamberlin, LA, Korbee, LL et al.. Childhood and Adolescent Migraine Prevention (CHAMP) study: a double-blinded, placebo-controlled, comparative effectiveness study of amitriptyline, topiramate, and placebo in the prevention of childhood and adolescent migraine. Headache. 2013;53 (5):799-816. doi: 10.1111/head.12105. PubMed PMID:23594025 PubMed Central PMC3637406.
  5. Richter, U, Lahtinen, T, Marttinen, P, Myöhänen, M, Greco, D, Cannino, G et al.. A mitochondrial ribosomal and RNA decay pathway blocks cell proliferation. Curr Biol. 2013;23 (6):535-41. doi: 10.1016/j.cub.2013.02.019. PubMed PMID:23453957 .
  6. Jõers, P, Jacobs, HT. Analysis of replication intermediates indicates that Drosophila melanogaster mitochondrial DNA replicates by a strand-coupled theta mechanism. PLoS One. 2013;8 (1):e53249. doi: 10.1371/journal.pone.0053249. PubMed PMID:23308172 PubMed Central PMC3537619.
  7. El-Khoury, R, Dufour, E, Rak, M, Ramanantsoa, N, Grandchamp, N, Csaba, Z et al.. Alternative oxidase expression in the mouse enables bypassing cytochrome c oxidase blockade and limits mitochondrial ROS overproduction. PLoS Genet. 2013;9 (1):e1003182. doi: 10.1371/journal.pgen.1003182. PubMed PMID:23300486 PubMed Central PMC3536694.

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2012

  1. Cannino, G, El-Khoury, R, Pirinen, M, Hutz, B, Rustin, P, Jacobs, HT et al.. Glucose modulates respiratory complex I activity in response to acute mitochondrial dysfunction. J Biol Chem. 2012;287 (46):38729-40. doi: 10.1074/jbc.M112.386060. PubMed PMID:23007390 PubMed Central PMC3493916.
  2. Stefanatos, R, Sriram, A, Kiviranta, E, Mohan, A, Ayala, V, Jacobs, HT et al.. dj-1β regulates oxidative stress, insulin-like signaling and development in Drosophila melanogaster. Cell Cycle. 2012;11 (20):3876-86. doi: 10.4161/cc.22073. PubMed PMID:22983063 PubMed Central PMC3495829.
  3. Chen, S, Oliveira, MT, Sanz, A, Kemppainen, E, Fukuoh, A, Schlicht, B et al.. A cytoplasmic suppressor of a nuclear mutation affecting mitochondrial functions in Drosophila. Genetics. 2012;192 (2):483-93. doi: 10.1534/genetics.112.143719. PubMed PMID:22851652 PubMed Central PMC3454878.
  4. Schiff, M, Bénit, P, Jacobs, HT, Vockley, J, Rustin, P. Therapies in inborn errors of oxidative metabolism. Trends Endocrinol Metab. 2012;23 (9):488-95. doi: 10.1016/j.tem.2012.04.006. PubMed PMID:22633959 PubMed Central PMC4135311.
  5. Humphrey, DM, Parsons, RB, Ludlow, ZN, Riemensperger, T, Esposito, G, Verstreken, P et al.. Alternative oxidase rescues mitochondria-mediated dopaminergic cell loss in Drosophila. Hum Mol Genet. 2012;21 (12):2698-712. doi: 10.1093/hmg/dds096. PubMed PMID:22398207 .

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