Multiple sclerosis (MS) is a demyelinating and neurodegenerative disease of the central nervous system (CNS), where peripheral and CNS-derived inflammation plays a significant role. Lack of detailed understanding of the immunopathogenesis of MS has hindered the development of effective neuroprotective treatments.
The Neuroimmunology research group focused on investigating the pathogenesis of MS. Primarily, we are interested in revealing the neuroinflammatory mechanisms of the CNS-resident cells astrocytes and microglia in MS as pathological studies have highlighted their role in promoting neurodegeneration and demyelination in MS.
Our research projects utilize stem cell technology by modeling brain cell functions and developing an in vitro human cell culture disease model. We have produced MS-patient derived human induced pluripotent stem cell (hiPSC) lines that are differentiated to astrocytes, microglia and neurons. Our projects are focused on modeling the role of astrocytes and microglia on the inflammatory environment and their crosstalk to peripheral immune cells and neurons in MS. We utilize in our research standard 2D and microfluidics chips techniques.