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Articles
2023
Ignatova I, Frolov R, and Nymark S. (2023) The retinal pigment epithelium displays electrical excitability and lateral signal spreading. BMC Biology. 17; 21(1):84. https://doi.org/10.1186/s12915-023-01559-5
2022
Fadjukov J, Wienbar S, Hakanen S, Aho V, Vihinen-Ranta M, Ihalainen TO, Schwartz G & Nymark S. (2022) Gap junctions and connexin hemichannels both contribute to the electrical properties of retinal pigment epithelium. Journal of General Physiology. 154 (4): e202112916. https://doi.org/10.1085/jgp.202112916
Korkka I, Skottman H, and Nymark S. (2022) Heterogeneity of Potassium Channels in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium. Stem Cells Translational Medicine. 11(7):753-766. https://doi.org/10.1093/stcltm/szac029
Viheriälä T, Hongisto H, Sorvari J, Skottman H, Nymark S & Ilmarinen T. (2022) Cell maturation influences the ability of hESC-RPE to tolerate cellular stress. Stem Cell Research & Therapy. 13 (1):30. https://doi.org/10.1186/s13287-022-02712-7
Isomäki M, Fedele C, Kääriäinen L, Mäntylä E, Nymark S, Ihalainen TO & Priimägi A. (2022) Light-Responsive Bilayer Cell Culture Platform for Reversible Cell Guidance. Small Science, 2, 2100099. https://doi.org/10.1002/smsc.202100099
2021
Viheriälä T*, Sorvari J*, Ihalainen TO, Mörö A, Grönroos P, Schlie-Wolter S, Chichkov B, Skottman H, Nymark S* & Ilmarinen T*. (2021) Culture surface protein coatings affect the barrier properties and calcium signalling of hESC-RPE. Scientific Reports, 11, 933. *Equal contributions. https://doi.org/10.1038/s41598-020-79638-8
2020
Fedele C, Mäntylä E, Belardi B, Hamkins-Indik T, Cavalli S, Netti PA, Fletcher DA, Nymark S, Priimägi A & Ihalainen TO. (2020) Azobenzene-based sinusoidal surface topography drives focal adhesion confinement and guides collective migration of epithelial cells. Scientific Reports, 10, Article number: 15329. https://doi.org/10.1038/s41598-020-71567-w
2019
Sorvari J, Viheriälä T, Ilmarinen T, Ihalainen TO & Nymark S. (2019) Analysis of ATP-Induced Ca2+ Responses at Single Cell Level in Retinal Pigment Epithelium Monolayers. Advances in Experimental Medicine and Biology. 1185:525-530. https://doi.org/10.1007/978-3-030-27378-1_86
Johansson JK, Karema-Jokinen VI, Hakanen S, Jylhä A, Uusitalo H, Vihinen-Ranta M, Skottman H, Ihalainen TO & Nymark S. (2019) Sodium channels enable fast electrical signaling and regulate phagocytosis in the retinal pigment epithelium. BMC Biology, 17, Article number: 63. https://doi.org/10.1186/s12915-019-0681-1
Korkka I, Viheriälä T, Juuti-Uusitalo K, Uusitalo-Järvinen H, Skottman H, Hyttinen J & Nymark S. (2019) Functional Voltage-Gated Calcium Channels Are Present in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium. Stem Cells Translational Medicine. 8(2):179-193. https://doi.org/10.1002/sctm.18-0026
Alarautalahti V, Ragauskas S, Hakkarainen J, Uusitalo-Järvinen H, Uusitalo H, Hyttinen J, Kalesnykas G & Nymark S. (2019) Viability of Mouse Retinal Explant Cultures Assessed by Preservation of Functionality and Morphology. Investigative Ophthalmology and Visual Science. 60:1914-1927. https://doi.org/10.1167/iovs.18-25156
Tervonen A, Ihalainen TO, Nymark S & Hyttinen J. (2019) Structural dynamics of tight junctions modulate the properties of the epithelial barrier. PLoS ONE. 14(4):e0214876. https://doi.org/10.1371/journal.pone.0214876
2018
Alarautalahti V, Hiltunen M, Onnela N, Nymark S, Kellomäki M & Hyttinen J. (2018) Polypyrrole-coated electrodes show thickness-dependent stability in different conditions during 42-day follow-up in vitro. Journal of Biomedical Materials Research Part B: Applied Biomaterials. 106(6):2202-2213. https://doi.org/10.1002/jbm.b.34024
2017
Korkka I*, Johansson JK*, Skottman H, Hyttinen J & Nymark S. (2017) Characterization of chloride channels in human embryonic stem cell derived retinal pigment epithelium. IFMBE Proceedings. 65:454-457. *Equal contributions. https://doi.org/10.1007/978-981-10-5122-7_114
2016
Berry J, Frederiksen R, Nymark S, Yao Y, Chen J & Cornwall MC. (2016) Effect of Rhodopsin Phosphorylation on Dark-Adaptation in Mouse Rods. Journal of Neuroscience. 36(26):6973-6987. https://doi.org/10.1523/JNEUROSCI.3544-15.2016
Frederiksen R*, Nymark S*, Kolesnikov A, Berry J, Adler IV L, Koutalos Y, Kefalov V & Cornwall MC. (2016) Rhodopsin kinase and arrestin binding control the decay of photoactivated rhodopsin and dark adaptation of mouse rods. Journal of General Physiology. 148(1):1-11. *Equal contributions. https://doi.org/10.1085/jgp.201511538
2015
Ilmarinen T, Hiidenmaa H, Kööbi P, Nymark S, Sorkio A, Wang J-H, Stanzel BV, Thieltges F, Alajuuma P, Oksala O, Kataja M, Uusitalo H & Skottman H. (2015). Ultrathin Polyimide Membrane as Cell Carrier for Subretinal Transplantation of Human Embryonic Stem Cell Derived Retinal Pigment Epithelium. PLoS ONE. 10(11): e0143669. https://doi.org/10.1371/journal.pone.0143669
Vainio I, Abu Khamidakh A, Paci M, Skottman H, Juuti-Uusitalo K, Hyttinen J & Nymark S. (2015) Computational Model of Ca2+ Wave Propagation in Human Retinal Pigment Epithelial ARPE-19 Cells. PLoS ONE. 10(6): e0128434. https://doi.org/10.1371/journal.pone.0128434
2014
Ragauskas S, Leinonen H, Puranen J, Rönkkö S, Nymark S, Gurevicius K, Lipponen A, Kontkanen O, Puoliväli J, Tanila H & Kalesnykas G. (2014) Early retinal function deficit without prominent morphological changes in the R6/2 mouse model of Huntington´s disease. PLoS ONE. 9(12): e113317. https://doi.org/10.1371/journal.pone.0113317
Wang J-S, Nymark S, Estevez M.E, Frederiksen R, Shen S, Razafsky D, Hodzic D, Corbo JC, Cornwall MC & Kefalov VJ. (2014) Chromophore supply rate-limits mammalian photoreceptor dark adaptation. Journal of Neuroscience. 34:11212-21. https://doi.org/10.1523/JNEUROSCI.1245-14.2014
Tervonen A, Vainio I, Nymark S & Hyttinen J. (2014) Prediction of Passive Drug Permeability Across the Blood-Retinal Barrier. Pharmaceutical Research. 31(9):2297-2311. https://doi.org/10.1007/s11095-014-1325-3
2013
Juuti-Uusitalo K, Delporte C, Grégoire F, Perret J, Huhtala H, Savolainen V, Nymark S, Hyttinen J, Uusitalo H, Willermain F & Skottman H. (2013) Aquaporin expression and function in human pluripotent stem cell-derived retinal pigmented epithelial cells. Investigative Ophthalmology and Visual Sciences. 54(5)3510-9. https://doi.org/10.1167/iovs.13-11800
2012
Subrizi A, Hiidenmaa H, Ilmarinen T, Nymark S, Dubruel P, Uusitalo H, Yliperttula M, Urtti A & Skottman H. (2012) Generation of hESC-derived retinal pigment epithelium on biopolymer coated polyimide membranes. Biomaterials. 33(32):8047-54. https://doi.org/10.1016/j.biomaterials.2012.07.033
Nymark S*, Frederiksen R*, Woodruff ML, Cornwall MC & Fain GL. (2012) Bleaching of mouse rods: microspectrophotometry and suction-electrode recording. Journal of Physiology. 590(10):2353-64. *Equal contributions. https://doi.org/10.1113/jphysiol.2012.228627
2011
Heikkinen H, Vinberg F, Nymark S & Koskelainen A. (2011) Mesopic background lights enhance dark-adapted cone ERG flash responses in the intact mouse retina: a possible role for gap junctional decoupling. Journal of Neurophysiology. 105(5):2309-18. https://doi.org/10.1152/jn.00536.2010
2009
Haldin C*, Nymark S*ˠ, Aho A-C, Koskelainen A & Donner K. (2009). Rod phototransduction determines the trade-off of temporal integration and speed of vision in dark-adapted toads. Journal of Neuroscience. 29: 5716-5725. *Equal contributions, ˠCorresponding author. https://doi.org/10.1523/JNEUROSCI.3888-08.2009
Heikkinen H, Nymark S, Donner K & Koskelainen A. (2009). Temperature dependence of dark-adapted sensitivity and light-adaptation in photoreceptors with A1 visual pigments: a comparison of frog L-cones and rods. Vision Research. 49: 1717-28. https://doi.org/10.1016/j.visres.2009.03.024
2008
Heikkinen H, Nymark S & Koskelainen A. (2008). Mouse cone photoresponses obtained with electroretinogram from the isolated retina. Vision Research. 48(2): 264-272. https://doi.org/10.1016/j.visres.2007.11.005
2006
Nymark S*, Haldin C, Tenhu H & Koskelainen A. (2006). A new method for measuring free drug concentration: retinal tissue as a biosensor. Investigative Ophthalmology and Visual Science, 47: 2583-2588. *Corresponding author. https://doi.org/10.1167/iovs.05-1116
2005
Nymark S*, Heikkinen H, Haldin C, Donner K & Koskelainen A. (2005). Light responses and light adaptation in rat retinal rods at different temperatures. Journal of Physiology. 567.3: 923-938. *Corresponding author. https://doi.org/10.1113/jphysiol.2005.090662