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Pharmacology

The Immunopharmacology Research Group

Publications

in total
325 original articles and
84 reviews and chapters in textbooks (university level)

2024

  1. Tavast, IM, Solismaa, A, Lyytikäinen, LP, Mononen, N, Moilanen, E, Hämäläinen, M et al.. Leptin and leptin receptor gene polymorphisms and depression treatment response. Acta Neuropsychiatr. 2024; :1-8. doi: 10.1017/neu.2024.43. PubMed PMID:39529327 .
  2. Suonsyrjä, N, Metso, S, Moilanen, E, Mustonen, J, Jaatinen, P, Pörsti, I et al.. Haemodynamics of hyperthyroidism: increased cardiac work and findings related to vasodilatation. Eur Thyroid J. 2024;13 (5):. doi: 10.1530/ETJ-24-0090. PubMed PMID:39356807 PubMed Central PMC11558968.
  3. Pemmari, A, Moilanen, E. Macrophage and chondrocyte phenotypes in inflammation. Basic Clin Pharmacol Toxicol. 2024;135 (5):537-549. doi: 10.1111/bcpt.14085. PubMed PMID:39319534 .
  4. Sallomy, C, Awolade, P, Rahnasto-Rilla, M, Hämäläinen, M, Nousiainen, LP, Johansson, NG et al.. TRPA1 Inhibition Effects by 3-Phenylcoumarin Derivatives. ACS Med Chem Lett. 2024;15 (8):1221-1226. doi: 10.1021/acsmedchemlett.4c00072. PubMed PMID:39140042 PubMed Central PMC11318103.
  5. Ryyti, R, Hämäläinen, M, Tolonen, T, Mäki, M, Jaakkola, M, Peltola, R et al.. Lingonberry (- L.) Skin Extract Prevents Weight Gain and Hyperglycemia in High-Fat Diet-Induced Model of Obesity in Mice. Nutrients. 2024;16 (13):. doi: 10.3390/nu16132107. PubMed PMID:38999854 PubMed Central PMC11243352.
  6. Mäenpää, N, Tiainen, L, Hämäläinen, M, Luukkaala, T, Tanner, M, Lahdenperä, O et al.. Neuropilin-1 and placental growth factor as prognostic factors in metastatic breast cancer. BMC Cancer. 2024;24 (1):331. doi: 10.1186/s12885-024-12070-7. PubMed PMID:38468231 PubMed Central PMC10929217.
  7. Lehtola, T, Nummenmaa, E, Nieminen, R, Hämäläinen, M, Vuolteenaho, K, Moilanen, E et al.. The glucocorticoid dexamethasone alleviates allergic inflammation through a mitogen-activated protein kinase phosphatase-1-dependent mechanism in mice. Basic Clin Pharmacol Toxicol. 2024;134 (5):686-694. doi: 10.1111/bcpt.13995. PubMed PMID:38439200 .
  8. Kokko, E, Choudhary, MK, Mutanen, A, Honkonen, M, Tikkakoski, A, Koskela, JK et al.. Volume overload is a major characteristic in primary aldosteronism: a 3-year follow-up study. J Hypertens. 2024;42 (6):1057-1065. doi: 10.1097/HJH.0000000000003696. PubMed PMID:38406920 PubMed Central PMC11064919.

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2023

  1. Luostarinen, S, Hämäläinen, M, Pemmari, A, Moilanen, E. The regulation of TRPA1 expression and function by Th1 and Th2-type inflammation in human A549 lung epithelial cells. Inflamm Res. 2023;72 (7):1327-1339. doi: 10.1007/s00011-023-01750-y. PubMed PMID:37386145 PubMed Central PMC10352175.
  2. Halonen, L, Pemmari, A, Nummenmaa, E, Hämäläinen, M, Moilanen, T, Vuolteenaho, K et al.. Human Osteoarthritic Chondrocytes Express Nineteen Different TRP-Genes-TRPA1 and TRPM8 as Potential Drug Targets. Int J Mol Sci. 2023;24 (12):. doi: 10.3390/ijms241210057. PubMed PMID:37373205 PubMed Central PMC10298562.
  3. Taurio, J, Hautaniemi, EJ, Koskela, JK, Eräranta, A, Hämäläinen, M, Tikkakoski, A et al.. The characteristics of elevated blood pressure in abdominal obesity correspond to primary hypertension: a cross-sectional study. BMC Cardiovasc Disord. 2023;23 (1):161. doi: 10.1186/s12872-023-03150-w. PubMed PMID:36973671 PubMed Central PMC10045516.
  4. Scotece, M, Hämäläinen, M, Leppänen, T, Vuolteenaho, K, Moilanen, E. MKP-1 Deficiency Exacerbates Skin Fibrosis in a Mouse Model of Scleroderma. Int J Mol Sci. 2023;24 (5):. doi: 10.3390/ijms24054668. PubMed PMID:36902103 PubMed Central PMC10002998.
  5. Koskela, K, Sauni, R, Uitti, J, Oksa, P, Moilanen, E, Hämäläinen, M et al.. An Increase in Plasma Adipsin Levels Is Associated With Higher Cumulative Dust Exposure and Airway Obstruction in Foundry Workers. J Occup Environ Med. 2023;65 (3):203-209. doi: 10.1097/JOM.0000000000002736. PubMed PMID:36730948 .
  6. Taurio, J, Koskela, J, Sinisalo, M, Tikkakoski, A, Niemelä, O, Hämäläinen, M et al.. Urine sodium excretion is related to extracellular water volume but not to blood pressure in 510 normotensive and never-treated hypertensive subjects. Blood Press. 2023;32 (1):2170869. doi: 10.1080/08037051.2023.2170869. PubMed PMID:36708156 .
  7. Mäki-Opas, I, Hämäläinen, M, Moilanen, E, Scotece, M. TRPA1 as a potential factor and drug target in scleroderma: dermal fibrosis and alternative macrophage activation are attenuated in TRPA1-deficient mice in bleomycin-induced experimental model of scleroderma. Arthritis Res Ther. 2023;25 (1):12. doi: 10.1186/s13075-023-02994-z. PubMed PMID:36698198 PubMed Central PMC9875496.
  8. Mäki-Opas, I, Hämäläinen, M, Moilanen, LJ, Sood, H, Leppänen, T, Kummola, L et al.. TRPA1 Mediates Contact Hypersensitivity Induced by 2,4-Dinitrochlorobenzene. J Invest Dermatol. 2023;143 (6):1104-1108.e4. doi: 10.1016/j.jid.2022.12.014. PubMed PMID:36634816 .
  9. Flinkman, E, Vähätalo, I, Tuomisto, LE, Lehtimäki, L, Nieminen, P, Niemelä, O et al.. Association Between Blood Eosinophils and Neutrophils With Clinical Features in Adult-Onset Asthma. J Allergy Clin Immunol Pract. 2023;11 (3):811-821.e5. doi: 10.1016/j.jaip.2022.11.025. PubMed PMID:36473624 .

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2022

  1. Koskela, K, Sauni, R, Uitti, J, Oksa, P, Moilanen, E, Hämäläinen, M et al.. An Increase in Plasma Adipsin Levels Is Associated With Higher Cumulative Dust Exposure and Airway Obstruction in Foundry Workers. J Occup Environ Med. 2023;65 (3):203-209. doi: 10.1097/JOM.0000000000002736. PubMed PMID:36730948 .
  2. Ryyti, R, Hämäläinen, M, Leppänen, T, Peltola, R, Moilanen, E. Phenolic Compounds Known to Be Present in Lingonberry ( L.) Enhance Macrophage Polarization towards the Anti-Inflammatory M2 Phenotype. Biomedicines. 2022;10 (12):. doi: 10.3390/biomedicines10123045. PubMed PMID:36551801 PubMed Central PMC9776286.
  3. Flinkman, E, Vähätalo, I, Tuomisto, LE, Lehtimäki, L, Nieminen, P, Niemelä, O et al.. Association Between Blood Eosinophils and Neutrophils With Clinical Features in Adult-Onset Asthma. J Allergy Clin Immunol Pract. 2023;11 (3):811-821.e5. doi: 10.1016/j.jaip.2022.11.025. PubMed PMID:36473624 .
  4. Huuskonen, C, Hämäläinen, M, Kivikangas, N, Paavonen, T, Moilanen, E, Mennander, A et al.. Myocardial interaction of apixaban after experimental acute volume overload. J Int Med Res. 2022;50 (11):3000605221137474. doi: 10.1177/03000605221137474. PubMed PMID:36397004 PubMed Central PMC9679347.
  5. Laurikka, A, Vuolteenaho, K, Toikkanen, V, Rinne, T, Leppänen, T, Hämäläinen, M et al.. Inflammatory Glycoprotein YKL-40 Is Elevated after Coronary Artery Bypass Surgery and Correlates with Leukocyte Chemotaxis and Myocardial Injury, a Pilot Study. Cells. 2022;11 (21):. doi: 10.3390/cells11213378. PubMed PMID:36359773 PubMed Central PMC9653903.
  6. Pemmari, T, Hämäläinen, M, Ryyti, R, Peltola, R, Moilanen, E. Dried Bilberry ( L.) Alleviates the Inflammation and Adverse Metabolic Effects Caused by a High-Fat Diet in a Mouse Model of Obesity. Int J Mol Sci. 2022;23 (19):. doi: 10.3390/ijms231911021. PubMed PMID:36232316 PubMed Central PMC9569776.
  7. Huuskonen, C, Hämäläinen, M, Kivikangas, N, Paavonen, T, Moilanen, E, Mennander, AA et al.. Early reversibility of histological changes after experimental acute cardiac volume-overload. Am J Cardiovasc Dis. 2022;12 (4):205-211. . PubMed PMID:36147786 PubMed Central PMC9490159.
  8. Pemmari, T, Hämäläinen, M, Ryyti, R, Peltola, R, Moilanen, E. Cloudberry ( L.) Supplementation Attenuates the Development of Metabolic Inflammation in a High-Fat Diet Mouse Model of Obesity. Nutrients. 2022;14 (18):. doi: 10.3390/nu14183846. PubMed PMID:36145221 PubMed Central PMC9503149.
  9. Niemelä, T, Kankaanranta, H, Vähätalo, I, Loponen, J, Tuomisto, LE, Niemelä, O et al.. Relationship Between Soluble Urokinase Plasminogen Activator Receptor (suPAR) and Disease Outcome in Adult-Onset Asthma. J Asthma Allergy. 2022;15 :579-593. doi: 10.2147/JAA.S356083. PubMed PMID:35592386 PubMed Central PMC9112192.
  10. Lehtola, T, Nummenmaa, E, Tuure, L, Hämäläinen, M, Nieminen, RM, Moilanen, T et al.. Dexamethasone Attenuates the Expression of MMP-13 in Chondrocytes through MKP-1. Int J Mol Sci. 2022;23 (7):. doi: 10.3390/ijms23073880. PubMed PMID:35409238 PubMed Central PMC8998740.
  11. Archer, M, Niemelä, O, Hämäläinen, M, Moilanen, E, Leinonen, E, Kampman, O et al.. The role of alcohol use and adiposity in serum levels of IL-1RA in depressed patients. BMC Psychiatry. 2022;22 (1):158. doi: 10.1186/s12888-022-03784-8. PubMed PMID:35232419 PubMed Central PMC8889691.

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2021

  1. Ryyti, R, Pemmari, A, Peltola, R, Hämäläinen, M, Moilanen, E. Effects of Lingonberry ( L.) Supplementation on Hepatic Gene Expression in High-Fat Diet Fed Mice. Nutrients. 2021;13 (11):. doi: 10.3390/nu13113693. PubMed PMID:34835949 PubMed Central PMC8623941.
  2. Klemettilä, JP, Solismaa, A, Seppälä, N, Hämäläinen, M, Moilanen, E, Leinonen, E et al.. Glucagon-like peptide-1 serum levels are associated with weight gain in patients treated with clozapine. Psychiatry Res. 2021;306 :114227. doi: 10.1016/j.psychres.2021.114227. PubMed PMID:34610543 .
  3. Pemmari, A, Leppänen, T, Hämäläinen, M, Moilanen, T, Moilanen, E. Chondrocytes from Osteoarthritis Patients Adopt Distinct Phenotypes in Response to Central T1/T2/T17 Cytokines. Int J Mol Sci. 2021;22 (17):. doi: 10.3390/ijms22179463. PubMed PMID:34502384 PubMed Central PMC8431052.
  4. Pemmari, A, Tuure, L, Hämäläinen, M, Leppänen, T, Moilanen, T, Moilanen, E et al.. Effects of ibuprofen on gene expression in chondrocytes from patients with osteoarthritis as determined by RNA-Seq. RMD Open. 2021;7 (3):. doi: 10.1136/rmdopen-2021-001657. PubMed PMID:34497153 PubMed Central PMC8438934.
  5. Sorri, A, Järventausta, K, Kampman, O, Lehtimäki, K, Björkqvist, M, Tuohimaa, K et al.. Electroconvulsive therapy increases temporarily plasma vascular endothelial growth factor in patients with major depressive disorder. Brain Behav. 2021;11 (8):e02001. doi: 10.1002/brb3.2001. PubMed PMID:34342142 PubMed Central PMC8413728.
  6. Luostarinen, S, Hämäläinen, M, Hatano, N, Muraki, K, Moilanen, E. The inflammatory regulation of TRPA1 expression in human A549 lung epithelial cells. Pulm Pharmacol Ther. 2021;70 :102059. doi: 10.1016/j.pupt.2021.102059. PubMed PMID:34302984 .
  7. Kivimäki, K, Leppänen, T, Hämäläinen, M, Vuolteenaho, K, Moilanen, E. Pinosylvin Shifts Macrophage Polarization to Support Resolution of Inflammation. Molecules. 2021;26 (9):. doi: 10.3390/molecules26092772. PubMed PMID:34066748 PubMed Central PMC8125806.
  8. Luostarinen, S, Hämäläinen, M, Moilanen, E. Transient Receptor Potential Ankyrin 1 (TRPA1)-An Inflammation-Induced Factor in Human HaCaT Keratinocytes. Int J Mol Sci. 2021;22 (7):. doi: 10.3390/ijms22073322. PubMed PMID:33805042 PubMed Central PMC8037497.
  9. Koskela, K, Sauni, R, Oksa, P, Uitti, J, Moilanen, E, Lehtimäki, L et al.. High alveolar nitric oxide is associated with steeper lung function decline in foundry workers. J Breath Res. 2021;15 (3):. doi: 10.1088/1752-7163/abf272. PubMed PMID:33770784 .
  10. Kaskinen, AK, Keski-Nisula, J, Martelius, L, Moilanen, E, Hämäläinen, M, Rautiainen, P et al.. Lung Injury After Neonatal Congenital Cardiac Surgery Is Mild and Modifiable by Corticosteroids. J Cardiothorac Vasc Anesth. 2021;35 (7):2100-2107. doi: 10.1053/j.jvca.2021.01.017. PubMed PMID:33573926 .
  11. Kononoff, A, Vuolteenaho, K, Hämäläinen, M, Kautiainen, H, Elfving, P, Savolainen, E et al.. Metabolic Syndrome, Disease Activity, and Adipokines in Patients With Newly Diagnosed Inflammatory Joint Diseases. J Clin Rheumatol. 2021;27 (8):e349-e356. doi: 10.1097/RHU.0000000000001412. PubMed PMID:32453216 .

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2020

  1. Pemmari A, Leppänen T, Hämäläinen M, Moilanen T, Vuolteenaho K, Moilanen E. Widespread regulation of gene expression by glucocorticoids in chondrocytes from patients with osteoarthritis as determined by RNA-Seq. Arthritis Res Ther. 2020;22 (1):271.
    doi: 10.1186/s13075-020-02289-7. PubMed PMID:33203447.
  2. Tuure L, Pemmari A, Hämäläinen M, Moilanen T, Moilanen E. Regulation of gene expression by MF63, a selective inhibitor of microsomal PGE synthase 1 (mPGES1) in human osteoarthritic chondrocytes. Br J Pharmacol. 2020;177 (18):4134-4146.
    doi: 10.1111/bph.15142. PubMed PMID:32449517.
  3. Ryyti R, Hämäläinen M, Peltola R, Moilanen E. Beneficial effects of lingonberry (Vaccinium vitis-idaea L.) supplementation on metabolic and inflammatory adverse effects induced by high-fat diet in a mouse model of obesity. PLoS One. 2020;15 (5):e0232605.
    doi: 10.1371/journal.pone.0232605. PubMed PMID:32379797.
  4. Scotece M, Koskinen-Kolasa A, Pemmari A, Leppänen T, Hämäläinen M, Moilanen T, Moilanen E, Vuolteenaho K. Novel adipokine associated with OA: retinol binding protein 4 (RBP4) is produced by cartilage and is correlated with MMPs in osteoarthritis patients. Inflamm Res. 2020;69 (4):415-421.
    doi: 10.1007/s00011-020-01326-0. PubMed PMID:32095874.
  5. Kononoff A, Elfving P, Pussinen P, Hörkkö S, Kautiainen H, Arstila L, Laasonen L, Savolainen E, Niinisalo H, Rutanen J, Marjoniemi O, Hämäläinen M, Vuolteenaho K, Moilanen E, Kaipiainen-Seppänen O. Association of rheumatoid arthritis disease activity and antibodies to periodontal bacteria with serum lipoprotein profile in drug naive patients. Ann Med. ;52 (1-2):32-42.
    doi: 10.1080/07853890.2020.1724321. PubMed PMID:32011179 .
  6. Aula H, Skyttä T, Tuohinen S, Luukkaala T, Hämäläinen M, Virtanen V, Raatikainen P, Moilanen E, Kellokumpu-Lehtinen PL. ST2 levels increased and were associated with changes in left ventricular systolic function during a three-year follow-up after adjuvant radiotherapy for breast cancer. Breast. 2020;49 :183-186.
    doi: 10.1016/j.breast.2019.12.001. PubMed PMID:31862685.

2019

  1. Aula H, Skyttä T, Tuohinen S, Luukkaala T, Hämäläinen M, Virtanen V, Raatikainen P, Moilanen E, Kellokumpu-Lehtinen PL. Transforming growth factor beta 1 levels predict echocardiographic changes at three years after adjuvant radiotherapy for breast cancer. Radiat Oncol. 2019;14 (1):155.
    doi: 10.1186/s13014-019-1366-1. PubMed PMID:31470867.
  2. Outinen TK, Mantula P, Jaatinen P, Hämäläinen M, Moilanen E, Vaheri A, Huhtala H, Mäkelä S, Mustonen J. Glycoprotein YKL-40 is elevated and predicts disease severity in Puumala hantavirus infection. Viruses. 2019;11 (9):767.
    doi: 10.3390/v11090767. PubMed PMID:31438470.
  3. Tiainen L, Korhonen EA, Leppänen VM, Luukkaala T, Hämäläinen M, Tanner M, Lahdenperä O, Vihinen P, Jukkola A, Karihtala P, Aho S, Moilanen E, Alitalo K, Kellokumpu-Lehtinen PL. High baseline Tie1 level predicts poor survival in metastatic breast cancer. BMC Cancer. 2019;19 (1):732.
    doi: 10.1186/s12885-019-5959-8. PubMed PMID:31340773.
  4. Bannuru RR, Osani MC, Vaysbrot EE, Arden NK, Bennell K, Bierma-Zeinstra SMA, Kraus VB, Lohmander LS, Abbott JH, Bhandari M, Blanco FJ, Espinosa R, Haugen IK, Lin J, Mandl LA, Moilanen E, Nakamura N, Snyder-Mackler L, Trojian T, Underwood M, McAlindon TE. OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthritis Cartilage. 2019;27 (11):1578-1589.
    doi: 10.1016/j.joca.2019.06.011. PubMed PMID: 31278997.
  5. Mäki-Opas I, Hämäläinen M, Moilanen LJ, Haavikko R, Ahonen TJ, Alakurtti S, Moreira VM, Muraki K, Yli-Kauhaluoma J, Moilanen E. Pyrazine-fused triterpenoids block the TRPA1 ion channel in vitro and inhibit TRPA1-mediated acute inflammation in vivo. ACS Chem Neurosci. 2019;10 (6):2848-2857.
    doi: 10.1021/acschemneuro.9b00083. PubMed PMID:31034197.
  6. Tiainen L, Hämäläinen M, Luukkaala T, Tanner M, Lahdenperä O, Vihinen P, Jukkola A, Karihtala P, Moilanen E, Kellokumpu-Lehtinen PL. Low plasma IL-8 levels during chemotherapy are predictive of excellent long-term survival in metastatic breast cancer. Clin Breast Cancer. 2019;19 (4):e522-e533.
    doi: 10.1016/j.clbc.2019.03.006. PubMed PMID:31029558.
  7. Ilmarinen P, Tuomisto LE, Niemelä O, Hämäläinen M, Moilanen E, Kankaanranta H. YKL-40 and adult-onset asthma: Elevated levels in clusters with poorest outcome. J Allergy Clin Immunol Pract. 2019;7 (7):2466-2468.e3.
    doi: 10.1016/j.jaip.2019.03.043. PubMed PMID:30954645.
  8. Tuure L, Hämäläinen M, Nummenmaa E, Moilanen T, Moilanen E. Downregulation of microsomal prostaglandin E synthase-1 (mPGES-1) expression in chondrocytes is regulated by MAP kinase phosphatase-1 (MKP-1). Int Immunopharmacol. 2019;71 :139-143.
    doi: 10.1016/j.intimp.2019.03.014. PubMed PMID:30897501.
  9. Archer M, Kampman O, Bloigu A, Bloigu R, Luoto K, Kultti J, Hämäläinen M, Moilanen E, Leinonen E, Niemelä O. Assessment of alcohol consumption in depression follow-up using self-reports and blood measures including inflammatory biomarkers. Alcohol Alcoholism. 2019;54 (3):243-250.
    doi: 10.1093/alcalc/agz002. PubMed PMID:30809628.
  10. Archer M, Niemelä O, Luoto K, Kultti J, Hämäläinen M, Moilanen E, Koivukangas A, Leinonen E, Kampman O. Status of inflammation and alcohol use in a 6-month follow-up study of patients with major depressive disorder. Alcohol. 2019;81 :21-26.
    doi: 10.1016/j.alcohol.2019.02.001. PubMed PMID:30769022.
  11. Moilanen LJ, Hämäläinen M, Ilmarinen P, Kankaanranta H, Nieminen RM, Moilanen E, Lehtimäki L. Transient receptor potential ankyrin 1 enhances ovalbumin-induced acute allergic inflammation in murine models. Int Arch Allergy Immunol. 2019;178 (3):238-247.
    doi: 10.1159/000494932. PubMed PMID:30699406.
  12. Huuskonen C, Hämäläinen M, Paavonen T, Moilanen E, Mennander A. Monoamine oxidase A inhibition protects the myocardium after experimental acute volume overload. Anatol J Cardiol. 2019;21 (1):39-45.
    doi: 10.14744/AnatolJCardiol.2018.37336. PubMed PMID:30587705.
  13. Pemmari A, Paukkeri EL, Hämäläinen M, Leppänen T, Korhonen R, Moilanen E. MKP-1 promotes anti-inflammatory M(IL-4/IL-13) macrophage phenotype and mediates the anti-inflammatory effects of glucocorticoids. Basic Clin Pharmacol Toxicol. 2019;124 (4):404-415.
    doi: 10.1111/bcpt.13163. PubMed PMID:30388313 .
  14. Laavola M, Leppänen T, Hämäläinen M, Vuolteenaho K, Moilanen T, Nieminen R, Moilanen E. IL-6 in osteoarthritis: effects of pine stilbenoids. Molecules. 2019;24 (1):109.
    doi: 10.3390/molecules24010109. PubMed PMID:30597965.

2018

  1. Pemmari A, Leppänen T, Paukkeri EL, Scotece M, Hämäläinen M, Moilanen E. Attenuating effects of nortrachelogenin on IL-4 and IL-13 induced alternative macrophage activation and on bleomycin-induced dermal fibrosis. J Agric Food Chem. 2018;66 (51):13405-13413.
    doi: 10.1021/acs.jafc.8b03023. PubMed PMID:30458613.
  2. Aula H, Skyttä T, Tuohinen S, Luukkaala T, Hämäläinen M, Virtanen V, Raatikainen P, Moilanen E, Kellokumpu-Lehtinen PL. Decreases in TGF-β1 and PDGF levels are associated with echocardiographic changes during adjuvant radiotherapy for breast cancer. Radiat Oncol. 2018;13 (1):201.
    doi: 10.1186/s13014-018-1150-7. PubMed PMID:30340644.
  3. Sorri A, Järventausta K, Kampman O, Lehtimäki K, Björkqvist M, Tuohimaa K, Hämäläinen M, Moilanen E, Leinonen E. Effect of electroconvulsive therapy on brain-derived neurotrophic factor levels in patients with major depressive disorder. Brain Behav. 2018;8 (11):e01101.
    doi: 10.1002/brb3.1101. PubMed PMID:30273985.
  4. Äyräväinen L, Heikkinen AM, Kuuliala A, Ahola K, Koivuniemi R, Peltola J, Suomalainen A, Moilanen E, Hämäläinen M, Laasonen L, Meurman JH, Leirisalo-Repo M. Activity of rheumatoid arthritis correlates with oral inflammatory burden. Rheumatol Int. 2018;38 (9):1661-1669.
    doi: 10.1007/s00296-018-4108-z. PubMed PMID:30043237.
  5. Äyräväinen L, Heikkinen AM, Kuuliala A, Ahola K, Koivuniemi R, Moilanen E, Hämäläinen M, Tervahartiala T, Meurman JH, Leirisalo-Repo M, Sorsa T. Anti-rheumatic medication and salivary MMP-8, a biomarker for periodontal disease. Oral Dis. 2018;24 (8):1562-1571.
    doi: 10.1111/odi.12930. PubMed PMID:29969841.
  6. Kiiski H, Långsjö J, Tenhunen J, Ala-Peijari M, Huhtala H, Hämäläinen M, Moilanen E, Peltola J. S100B, NSE and MMP-9 fail to predict neurologic outcome while elevated S100B associates with milder initial clinical presentation after aneurysmal subarachnoid hemorrhage. J Neurol Sci. 2018;390 :129-134.
    doi: 10.1016/j.jns.2018.04.030. PubMed PMID:29801873.
  7. Pemmari A, Leppänen T, Paukkeri EL, Eskelinen A, Moilanen T, Moilanen E. Gene expression in adverse reaction to metal debris around metal-on-metal arthroplasty: An RNA-Seq-based study. J Trace Elem Med Biol. 2018;48 :149-156.
    doi: 10.1016/j.jtemb.2018.03.014. PubMed PMID:29773173.
  8. Eräsalo H, Hämäläinen M, Leppänen T, Mäki-Opas I, Laavola M, Haavikko R, Yli-Kauhaluoma J, Moilanen E. Natural stilbenoids have anti-inflammatory properties in vivo and down-regulate the production of inflammatory mediators NO, IL6 and MCP1 possibly in a PI3K/Akt-dependent manner. J Nat Prod. 2018;81 (5):1131-1142.
    doi: 10.1021/acs.jnatprod.7b00384. PubMed PMID:29726680.
  9. Äyräväinen L, Heikkinen AM, Kuuliala A, Ahola K, Koivuniemi R, Laasonen L, Moilanen E, Hämäläinen M, Tervahartiala T, Meurman JH, Leirisalo-Repo M, Sorsa T. Inflammatory biomarkers in saliva and serum of patients with rheumatoid arthritis with respect to periodontal status. Ann Med. 2018;50 (4):333-344.
    doi: 10.1080/07853890.2018.1468922. PubMed PMID:29683364.
  10. Sorri A, Järventausta K, Kampman O, Lehtimäki K, Björkqvist M, Tuohimaa K, Hämäläinen M, Moilanen E, Leinonen E. Low tumor necrosis factor-α levels predict symptom reduction during electroconvulsive therapy in major depressive disorder. Brain Behav. 2018;8 (4):e00933.
    doi: 10.1002/brb3.933. PubMed PMID:29670819.
  11. Toikkanen V, Rinne T, Nieminen R, Moilanen E, Laurikka J, Porkkala H, Tarkka M, Mennander AA. Aprotinin impacts 8-isoprostane after coronary artery bypass grafting. Scand J Surg. 2018;107(4):329-335.
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    doi: 10.1016/j.psychres.2018.03.073. PubMed PMID:29626829.
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  14. Alapirtti T, Lehtimäki K, Nieminen R, Mäkinen R, Raitanen J, Moilanen E, Mäkinen J, Peltola J. The production of IL-6 in acute epileptic seizure: A video-EEG study. J Neuroimmunol. 2018;316 :50-55.
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  16. Ihalainen JK, Peltonen H, Paulsen G, Ahtiainen JP, Taipale RS, Hämäläinen M, Moilanen E, Mero AA. Inflammation status of healthy young men: initial and specific responses to resistance training. Appl Physiol Nutr Metab. 2018;43 (3):252-258.
    doi: 10.1139/apnm-2017-0315. PubMed PMID:29053943.
  17. Salmivesi S, Paassilta M, Huhtala H, Nieminen R, Moilanen E, Korppi M. Elevated serum adipsin may predict unsuccessful treatment for cows’ milk allergy but other biomarkers do not. Acta Paediatr. 2018;107 (2):328-332.
    doi: 10.1111/apa.14117. PubMed PMID:29028118.
  18. Ihalainen JK, Schumann M, Eklund D, Hämäläinen M, Moilanen E, Paulsen G, Häkkinen K, Mero AA. Combined aerobic and resistance training decreases inflammation markers in healthy men. Scand J Med Sci Sports. 2018;28(1):40-47.
    doi: 10.1111/sms.12906. PubMed PMID: 28453868.
  19. Timonen JM, Vuolteenaho K, Leppänen T, Nieminen RM, Aulaskari P, Jänis J, Vainiotalo P, Moilanen E. Synthesis of novel psoralen derivatives – Structures with with distinct anti-inflammatory activities. J Heterocyclic Chem. 2018;55:2590-2597.
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