Latest publications
2026
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Quantification of Immediate Surgical Stress After Major and Minor Thoracic Surgeries Through HRV: A Secondary Post Hoc Analysis of a Randomized Controlled Trial
CONCLUSION: HRV parameters reflected surgery-induced autonomic alterations, with more pronounced and persistent changes observed in patients undergoing PR compared with PM surgery. No clear recovery toward baseline was detected during the 2-day postoperative follow-up, suggesting prolonged autonomic disturbances after thoracic surgery. -
VR-guided deep breathing during needle procedures in children
Virtual reality-based treatment has been found to be effective at reducing stress and fear in children during procedures involving needles, but its effects on the autonomic nervous system and heart rate variability remain uncertain. This feasibility study compared a virtual reality-mediated deep breathing exercise with treatment as usual in managing the stress and fear of children during a venipuncture. We included 45 children who underwent a needle procedure as part of their routine treatment.... -
Effect of liner geometry on jumping distance: as relevant as head size
BACKGROUND: Dislocation is a common complication after total hip arthroplasty (THA). Previously, we found that different liner models provided varying degrees of articulating head coverage. Jumping distance (JD) is a key indicator of joint stability. Therefore, we aimed to investigate the differences in JD values among various liner models. METHODS: JD values were determined using previously published articulating head coverage data for 25 modular polyethylene liners used in 6 uncemented cup... -
Effects of physiotherapy on breathing cycle after thoracic surgery measured with impedance pneumography in a prospective clinical comparison
CONCLUSIONS: IMT seemed to enhance expiration specifically among thoracotomy patients and thus may provide means for enhancing the recovery after thoracic operations.
2025
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Effects of physiotherapy on breathing cycle after thoracic surgery measured with impedance pneumography in a prospective clinical comparison
CONCLUSIONS: IMT seemed to enhance expiration specifically among thoracotomy patients and thus may provide means for enhancing the recovery after thoracic operations. -
Bioimpedance Measurement for Monitoring Chronic Wounds: A Systematic Review
Chronic wounds decrease patients' quality of life and pose an economic burden on healthcare systems and individuals. Wound assessment tools and monitoring technologies may reduce the costs related to chronic wound management. Bioimpedance has attracted growing attention as a quantitative tool for monitoring chronic ulcers, owing to its proven ability to detect tissue changes throughout the wound healing process. The main objective of this study was to review the state-of-the-art literature on...
2024
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Bioimpedance Measurement for Monitoring Chronic Wounds: A Systematic Review
Chronic wounds decrease patients' quality of life and pose an economic burden on healthcare systems and individuals. Wound assessment tools and monitoring technologies may reduce the costs related to chronic wound management. Bioimpedance has attracted growing attention as a quantitative tool for monitoring chronic ulcers, owing to its proven ability to detect tissue changes throughout the wound healing process. The main objective of this study was to review the state-of-the-art literature on... -
Use of ST/HR hysteresis decreases false positive rate in exercise electrocardiography test of middle-aged asymptomatic women
CONCLUSION: In asymptomatic middle-aged women, practitioners should prefer the use of ST/HR hysteresis and ST-segment after one-minute recovery over the conventional ST-segment depression at peak exercise or ST/HR index, and evaluate the ECG data from a two‑lead configuration instead of single‑lead. -
Are some neutral liners more neutral than others? An ex vivo morphological analysis of acetabular liners classified as "neutral"
CONCLUSION: We showed that all neutral liners are not equal - instead, they clearly varied in terms of their actual coverage design. We suggest our set of descriptive parameters called "hemispheric coverage index values" be used in discriminating the differences in liner coverage. -
Bioimpedance sensor array for monitoring chronic wounds: Validation of method feasibility
In an ageing society, the incidence of hard-to-heal wounds is rising. Chronic wound healing is a complex process, which requires specialised treatment. Clinical assessment of the wound is essential to establish care approaches but is usually based on visual evaluation and it remains challenging. Therefore, innovative quantitative methods for the assessment of chronic wounds are needed. We conducted a single-centre observational study designed to assess the feasibility of a bioimpedance... -
Prediction of Sudden Cardiac Death With Ultra-Short-Term Heart Rate Fluctuations
CONCLUSIONS: Ultra-short-term DFA2 α(1), when measured at rest, is a powerful and independent predictor of SCD. The association between DFA2 α(1) and SCD is modified by physical exertion. -
Performance Evaluation of QT-RR Adaptation Time Lag Estimation in Exercise Stress Testing
CONCLUSIONS: Using simulated ECGs, the performance evaluation of the proposed method shows that the estimated time lag agrees well with the true time lag.
2023
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Effects of Using Guided Deep Breathing Exercises in a Virtual Natural Environment to Reduce Stress during Pediatric Treatment
There exists a need for new methods to address treatment anxiety in pediatrics-at the same time, deep breathing exercises and virtual natural environments have both been known to have stress-reducing qualities. This article reports the combined effect of these two methods in a pediatric setting. A feasibility study was conducted in a local hospital. The study had a within-subjects design, and it included 21 child patients aged 8 to 12 years old, who used a virtual reality (VR) relaxation...
2022
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Prediction of Sudden Cardiac Death With Ultra-Short-Term Heart Rate Fluctuations
CONCLUSIONS: Ultra-short-term DFA2 α(1), when measured at rest, is a powerful and independent predictor of SCD. The association between DFA2 α(1) and SCD is modified by physical exertion. -
Resting heart rate predicts cardiac autonomic modulation during passive head-up tilt in subjects without cardiovascular diseases
Background Resting heart rate (HR) and its variability (HRV) reflects the cardiac sympathovagal balance that is stimulated by head-up tilting. HRV is influenced by the level of HR, but how much HRV offers additional information about cardiac autonomic tone than HR alone remains unresolved. We examined the relation of resting HR with HRV during head-up tilt. Methods. Hemodynamics of 569 subjects without known cardiovascular diseases and medications with direct cardiovascular effects were recorded... -
Evaluation of the QRS score for diagnosing coronary artery disease in women: A Finnish cardiovascular study
CONCLUSIONS: This study suggests that the QRS and ST-segment depression have a moderate diagnostic ability to predict coronary artery disease in women. Q and R waves in lead aVF showed good diagnostic ability.
2021
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QT variability unrelated to RR variability during stress testing for identification of coronary artery disease
Stress test electrocardiogram (ECG) analysis is widely used for coronary artery disease (CAD) diagnosis despite its limited accuracy. Alterations in autonomic modulation of cardiac electrical activity have been reported in CAD patients during acute ischemia. We hypothesized that those alterations could be reflected in changes in ventricular repolarization dynamics during stress testing that could be measured through QT interval variability (QTV). However, QTV is largely dependent on RR interval... -
Individual changes of central blood pressure in response to upright posture: different hemodynamic phenotypes
CONCLUSION: In participants without cardiovascular disease, the changes in central SBP during orthostatic challenge are not uniform. One-third presented with higher upright than supine aortic SBP with underlying differences in the regulation of systemic vascular resistance and cardiac output. These findings emphasize that resting blood pressure measurements give only limited information about the blood pressure status. -
Bioimpedance method for monitoring venous ulcers: Clinical proof-of-concept study
Evaluation of wound status is typically based on means which require the removal of dressings. These procedures are often also subjective and prone to inter-observer bias. To overcome aforementioned issues a bioimpedance measurement-based method and measurement system has been developed to evaluate the state of wound healing. The measurement system incorporated a purpose-built bioimpedance device, a measurement software and a screen-printed electrode array. The feasibility and the performance of...
2020
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Prediction of Sudden Cardiac Death With Ultra-Short-Term Heart Rate Fluctuations
CONCLUSIONS: Ultra-short-term DFA2 α(1), when measured at rest, is a powerful and independent predictor of SCD. The association between DFA2 α(1) and SCD is modified by physical exertion. -
Evaluation of the QRS score for diagnosing coronary artery disease in women: A Finnish cardiovascular study
CONCLUSIONS: This study suggests that the QRS and ST-segment depression have a moderate diagnostic ability to predict coronary artery disease in women. Q and R waves in lead aVF showed good diagnostic ability. -
Expiratory variability index is associated with asthma risk, wheeze and lung function in infants with recurrent respiratory symptoms
Impedance pneumography enables the measurement of the expiratory variability index (EVI) at home during a night's sleep in infants with recurrent respiratory symptoms. EVI is associated with asthma risk, symptoms and lung function. https://bit.ly/2PF2cx8. -
Reduced expiratory variability index (EVI) is associated with controller medication withdrawal and symptoms in wheezy children aged 1-5 years
CONCLUSION: EVI was lower in patients than in controls and it reduced further after controller medication withdrawal, especially in the presence of parentally perceived wheeze symptoms. This technique shows a significant potential for routine lung function testing of wheezy young children. -
A device for measuring sternal bone connectivity using vibration analysis techniques
CONCLUSION: Technical solutions and description of validation process were given. The device was calibrated, and the vibration transmittance analysis differentiated intact and cut polylactide rod. In the sternum, intact bone, wire fixation with exact apposition, and with a gap were identified separately. Although further studies are needed to assess the accuracy of the method to detect different levels of diastases, the method appears to be feasible. -
Noninvasive Cardiorespiratory Signals Analysis for Asthma Evolution Monitoring in Preschool Children
CONCLUSION: Results suggest that HRV analysis could be useful for the continuous monitoring of ANS anomalies present in asthma, thus contributing to evaluate the evolution of the disease, which is especially challenging in young children. -
Tidal breathing flow profiles during sleep in wheezing children measured by impedance pneumography
For the first time, impedance pneumography (IP) enables a continuous analysis of the tidal breathing flow volume (TBFV), overnight. We studied how corticosteroid inhalation treatments, sleep stage, and time from sleep onset modify the nocturnal TBFV profiles of children. Seventy children, 1-5 years old and with recurrent wheezing, underwent three, full-night TBFVs recordings at home, using IP. The first recorded one week before ending a 3-months inhaled corticosteroids treatment, and remaining...
2019
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A device for measuring sternal bone connectivity using vibration analysis techniques
CONCLUSION: Technical solutions and description of validation process were given. The device was calibrated, and the vibration transmittance analysis differentiated intact and cut polylactide rod. In the sternum, intact bone, wire fixation with exact apposition, and with a gap were identified separately. Although further studies are needed to assess the accuracy of the method to detect different levels of diastases, the method appears to be feasible. -
Noninvasive Cardiorespiratory Signals Analysis for Asthma Evolution Monitoring in Preschool Children
CONCLUSION: Results suggest that HRV analysis could be useful for the continuous monitoring of ANS anomalies present in asthma, thus contributing to evaluate the evolution of the disease, which is especially challenging in young children. -
Combination of low blood pressure response, low exercise capacity and slow heart rate recovery during an exercise test significantly increases mortality risk
Aims: We investigated the combination of low systolic blood pressure (SBP) response, low exercise capacity (EC) and slow heart rate recovery (HRR) during an exercise test in mortality prediction.Patients and methods: Our population consisted of 3456 patients from the Finnish Cardiovascular Study. A failure of SBP to increase >42 mmHg was defined as a low response. Low EC was defined as < 8 metabolic equivalents. 1-minute HRR ≤18 bpm from maximum was defined as slow HRR.Results: During a median... -
Tidal breathing flow profiles during sleep in wheezing children measured by impedance pneumography
For the first time, impedance pneumography (IP) enables a continuous analysis of the tidal breathing flow volume (TBFV), overnight. We studied how corticosteroid inhalation treatments, sleep stage, and time from sleep onset modify the nocturnal TBFV profiles of children. Seventy children, 1-5 years old and with recurrent wheezing, underwent three, full-night TBFVs recordings at home, using IP. The first recorded one week before ending a 3-months inhaled corticosteroids treatment, and remaining... -
Airway obstruction is associated with reduced variability in specific parts of the tidal breathing flow-volume curve in young children
Impedance pneumography recordings during sleep at night show reduced variability in specific parts of the expiratory flow-volume curve in children with recurrent wheeze http://bit.ly/2Wkfap0. -
Bioimpedance Sensor Array for Long-Term Monitoring of Wound Healing from Beneath the Primary Dressings and Controlled Formation of H<sub>2</sub>O<sub>2</sub> Using Low-Intensity Direct Current
Chronic wounds impose a significant financial burden for the healthcare system. Currently, assessment and monitoring of hard-to-heal wounds are often based on visual means and measuring the size of the wound. The primary wound dressings must be removed before assessment can be done. We have developed a quasi-monopolar bioimpedance-measurement-based method and a measurement system to determine the status of wound healing. The objective of this study was to demonstrate that with an appropriate... -
Tidal breathing flow volume profiles during sleep in wheezing infants measured by impedance pneumography
Overnight analysis of tidal breathing flow volume (TBFV) loops, recorded by impedance pneumography (IP), has been successfully applied in the home monitoring of children with wheezing disorders. However, little is known on how sleep physiology modifies the relationship between TBFV profiles and wheeze. We studied such interactions in wheezing infants. Forty-three infants recruited because of recurrent lower airway symptoms were divided into three groups based on their risk of asthma: high (HR),... -
The Duke treadmill score with bicycle ergometer: Exercise capacity is the most important predictor of cardiovascular mortality
CONCLUSIONS: The Duke treadmill score is associated with cardiovascular mortality among patients who have undergone bicycle exercise testing, but metabolic equivalents of task, a component of the Duke treadmill score, proved to be a superior predictor. -
Metabolic syndrome is associated with decreased heart rate variability in a sex-dependent manner: a comparison between 252 men and 249 women
Impaired heart rate variability (HRV) is associated with increased risk of cardiovascular disease, but evidence regarding alterations of HRV in metabolic syndrome (MetS) remains elusive. In order to examine HRV in MetS, we subjected 501 volunteers without atherosclerosis, diabetes or antihypertensive medication, mean age 48 years, to passive head-up tilt. The subjects were divided to control men (n = 131), men with MetS (n = 121), control women (n = 191) and women with MetS (n = 58) according to...
2018
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The Duke treadmill score with bicycle ergometer: Exercise capacity is the most important predictor of cardiovascular mortality
CONCLUSIONS: The Duke treadmill score is associated with cardiovascular mortality among patients who have undergone bicycle exercise testing, but metabolic equivalents of task, a component of the Duke treadmill score, proved to be a superior predictor. -
Metabolic syndrome is associated with decreased heart rate variability in a sex-dependent manner: a comparison between 252 men and 249 women
Impaired heart rate variability (HRV) is associated with increased risk of cardiovascular disease, but evidence regarding alterations of HRV in metabolic syndrome (MetS) remains elusive. In order to examine HRV in MetS, we subjected 501 volunteers without atherosclerosis, diabetes or antihypertensive medication, mean age 48 years, to passive head-up tilt. The subjects were divided to control men (n = 131), men with MetS (n = 121), control women (n = 191) and women with MetS (n = 58) according to... -
Nocturnal Heart Rate Variability Spectrum Characterization in Preschool Children With Asthmatic Symptoms
Asthma is a chronic lung disease that usually develops during childhood. Despite that symptoms can almost be controlled with medication, early diagnosis is desirable in order to reduce permanent airway obstruction risk. It has been suggested that abnormal parasympathetic nervous system (PSNS) activity might be closely related with the pathogenesis of asthma, and that this PSNS activity could be reflected in cardiac vagal control. In this work, an index to characterize the spectral distribution... -
Detection of Snores Using Source Separation on an Emfit Signal
Snoring (SN) is an early sign of upper airway dysfunction, and it is strongly associated with obstructive sleep apnea. SN detection is important to monitor SN objectively and to improve the diagnostic sensitivity of sleep-disordered breathing. In this study, an automatic snore detection method using an electromechanical film transducer (Emfit) signal is presented. Representative polysomnographs of normal breathing and SN periods from 30 subjects were selected. Individual SN events were...