We investigate the spatial and temporal dynamics of gene regulation in disease. Using single-cell and spatial genomics, our group maps cell type–specific regulatory programs relevant to disease onset and progression, with the overarching goal of understanding how these regulatory processes reside within the disease microenvironment, and how genetic variation influences them. Together, these build a genotype-to-phenotype-to-pathology framework for disease-relevant gene regulation.
Our research focus areas
- Neurodegeneration — mapping the temporal dynamics of brain cell type gene regulation and its spatial relationship to disease pathology in the brain.
- Cancer — characterizing regulatory processes underlying tumor pathology and treatment resistance.
- Technology development — advancing single-cell and spatial genomics methods to enable dynamic, spatially resolved regulatory analysis