Publications focusing on natural products by
The Immunopharmacology Research Group, Tampere University
MITY, Kajaani University Consortium, University of Oulu
Results of the ERDF funded projects A72934 and A76028
T. Pemmari, M. Hämäläinen, R. Ryyti, R. Peltola, Eeva Moilanen: Cloudberry (Rubus chamaemorus L.) supplementation attenuates the development of metabolic inflammation in a mouse high-fat diet model of obesity. Nutrients, 14: 3846, 2022.
T. Pemmari, M. Hämäläinen, R. Ryyti, R. Peltola, E. Moilanen: Dried bilberry (Vaccinium myrtillus L.) alleviates inflammation and adverse metabolic effects caused by high-fat diet in a mouse model of obesity. Int J Mol Sci, 23: 11021, 2022.
R. Ryyti, M. Hämäläinen, T. Leppänen, R. Peltola, E. Moilanen: Phenolic compounds known to be present in lingonberry (Vaccinium vitis-idaea L.) enhance macrophage polarization towards the anti-inflammatory M2 phenotype. Biomedicines, 10: 3045, 2022.
R. Ryyti, A. Pemmari, R. Peltola, M. Hämäläinen, E. Moilanen: Effects of lingonberry (Vaccinium vitis-idaea L.) supplementation on hepatic gene expression in the liver in high-fat diet fed mice. Nutrients, 13: 3693, 2021.
Previous publications
K. Kivimäki, T. Leppänen, M. Hämäläinen, K. Vuolteenaho, E. Moilanen: Pinosylvin shifts macrophage polarization to support resolution of inflammation. Molecules, 26:2772,2021.
R. Ryyti, M. Hämäläinen, R. Peltola, E. Moilanen: Beneficial effects of lingonberry (Vaccinium vitis-idaea L.) supplementation on metabolic and inflammatory adverse effects induced by high-fat diet in a mouse model of obesity. PLos One, 15:e0232605, 2020.
M. Laavola, T. Leppänen, M. Hämäläinen, K. Vuolteenaho, T. Moilanen, R. Nieminen, E. Moilanen: IL-6 in osteoarthritis: effects of pine stilbenoids. Molecules 2019, 24:2019.
I. Mäki-Opas, M. Hämäläinen, L. Moilanen, R. Haavikko, T.J. Ahonen, S. Alakurtti, V.M.Moreira, K. Muraki, J. Yli-Kauhaluoma, E. Moilanen: Pyrazine-fused triterpenoids block TRPA1 ion channel in vitro and inhibit TRPA1-mediated acute inflammation in vivo. ACS Chem Neurosci. 19;10(6):2848-2857,2019.
H. Eräsalo, M. Hämäläinen, T. Leppänen, I. Mäki-Opas, M. Laavola, R. Haavikko, J. Yli-Kauhaluoma, E. Moilanen: Natural stilbenoids have anti-inflammatory properties and down-regulate the expression of inflammatory mediators NO, IL6 and MCP1 possiblyin a PI3K/Akt-dependent manner. J Nat Prod. 25;81(5):1131-1142, 2018 .
M. Laavola, T. Leppänen, H. Eräsalo, M. Hämäläinen, R. Nieminen, E. Moilanen: Anti-inflammatory effects of nortrachelogenin in murine J774 macrophages and in carrageenan-induced paw edema model in the mouse. Planta Med 83(6):519-526, 2017.
R. Puupponen-Pimiä, L. Nohynek, R. Juvonen, T. Kössö, P. Truchado, B. Westerlund-Wikström, T. Leppänen, E. Moilanen, K.-M. Oksman-Caldentey: Fermentation and dry fractionation increase bioactivity of cloudberry (Rubus chamaemorus). Food Chem197:950-958, 2016.
L.J. Moilanen, M. Hämäläinen, L. Lehtimäki, R.M. Nieminen, K. Muraki, E. Moilanen: Pinosylvin inhibits TRPA1-induced calcium influx in vitro and TRPA1-mediated acute paw inflammation in vivo. Basic Clin Pharmacol Toxicol 18:238-242, 2016.
M. Laavola, R. Haavikko, M. Hämäläinen, T. Leppänen, R. Nieminen, S. Alakurtti, V.Moreira, J. Yli-Kauhaluoma, E. Moilanen: Betulin derivatives effectively suppress inflammation in vitro and in vivo. J Nat Prod 79:274-280, 2016.
Timonen, K. Vuolteenaho, T. Leppänen, R. Nieminen, E. Moilanen, P. Aulaskari, J. Jänis: 7-(2-Oxoalkoxy)coumarins – Synthesis and anti-inflammatory activity of a series of substituted coumarins. J Het Chem 52:1273–1295, 2015.
M. Laavola, R. Nieminen, T. Leppänen, C. Eckerman, B. Holmbom, E. Moilanen: Pinosylvin and monomethyl pinosylvin, constituents of extract from the knot of pinus sylvestris, reduce inflammatory gene expression and inflammatory response in vivo. J Agric Food Chem 63:3445-3453, 2015.
R. Puupponen-Pimiä, T. Seppänen-Laakso, J. Maukonen, R. Törrönen, M. Kolehmainen, M. Kankainen, T. Leppänen, E. Moilanen: Effects of ellagitannin rich berries on blood lipid profiles, gut microbiota and metabolism of phenolic compounds in metabolic
syndrome. DOSIS 33:55-76, 2015.
E. Spilioti, M. Jaakkola, T. Tolonen, M. Lipponen, V. Virtanen, I. Chinou, E. Kassi, S. Karabournioti, P. Moutsatsou: Phenolic acid composition, antiatherogenic and anticancer potential of honeys derived from various regions in Greece. PLoS One 9 (4), 2014.
R. Puupponen-Pimiä, T. Seppänen-Laakso, M. Kankainen, J. Maukonen, R. Törrönen, M. Kolehmainen, T. Leppänen, E. Moilanen, L. Nohynek, A.-M. Aura, K. Poutanen, F.A. Tómas-Barberán, J.C. Espin, K.-M. Oksman-Caldentey: Effects of ellagitannin-rich berries on blood lipids, gut microbiota and urolithin production in human subjects with symptoms of metabolic syndrome. Mol Nutr Food Res 57:2258-2263, 2013.
T. Kallio, J. Kallio, M. Jaakkola, M. Mäki, P. Kilpeläinen, V. Virtanen: Urolithins display both antioxidant and pro-oxidant activities depending on assay system and conditions. Journal of Agricultural and Food Chemistry 61 (45), 10720-10729, 2013.
M. Jaakkola, V. Korpelainen, K. Hoppula, V. Virtanen: Chemical composition of ripe fruits of Rubus chamaemorus L. grown in different habitats. – Journal of the Science of Food and Agriculture 92 (6), 1324-1330,2012.
M. Laavola, R. Nieminen, M.F. Yam, A. Sadikun, M.Z. Asmawi, R. Basir, J. Welling, H. Vapaatalo, R. Korhonen, E. Moilanen: Flavonoids eupatorin and sinensetin present in Orthosiphon stamineus leaves inhibit inflammatory gene expression and STAT1 activation. Planta Med 78:779-786, 2012.
M. Kolehmainen, O. Mykkänen, P. Kirjavainen, T. Leppänen, E. Moilanen, M. Adriaens, D. Laaksonen, M. Hallikainen, R. Puupponen-Pimiä, L. Pulkkinen, H. Mykkänen, H. Gylling, K. Poutanen, R. Törrönen: Bilberries reduce low-grade inflammation in individuals with features of metabolic syndrome. Mol Nutr Food Res 56:1501-1510,2012.
J. Kallio, M. Jaakkola, M. Mäki, P. Kilpeläinen, V. Virtanen: Vitamin C inhibits Staphylococcus aureus growth and enhances the inhibitory effect of Quercetin on growth of Escherichia coli in vitro. Planta Medica 78 (17), 1824-1830, 2012.
O. Laaksonen, M. Sandell, E. Norlund, R-L. Heiniö, H-L. Malinen, M. Jaakkola, H. Kallio: The effect of enzymatic treatment on blackcurrant (Ribes nigrum) juice flavour and its stability. Food chemistry 130 (1), 31-41, 2012.
N. Pap, M. Mahosenaho, E. Pongrácz, H. Mikkonen, M. Jaakkola, V. Virtanen, L. Myllykoski, Z. Horváth-Hovorka, C. Hodúr, G. Vata, R. Keiski: Effect of ultrafiltration on anthocyanin and flavonol content of black currant juice (Ribes nigrum L.). Food and Bioprocess Technology 5 (3), 921-928, 2012.
J.M. Timonen, R. Nieminen, O. Sareila, A. Goulas, L.J. Moilanen, M. Haukka, P. Vainiotalo, E. Moilanen, P.H. Aulaskari: Synthesis and anti-inflammatory effects of a series of novel 7-hydroxycoumarin derivatives. Eur J Med Chem 46:3845-3850, 2011.
M. Hämäläinen, R. Nieminen, M.Z. Asmawi, P. Vuorela, H. Vapaatalo, E. Moilanen: Effects of flavonoids on prostaglandin E2 production, and on COX-2 and mPGES-1 expressions in activated macrophages. Planta Med 77:1504-1511, 2011.
P. Kylli, L. Nohynek, R. Puupponen-Pimiä, B. Westerlund-Wikström, T. Leppänen, J. Welling, E. Moilanen, M.I. Heinonen: Lingonberry (Vaccinium vitis-idaea) and European cranberry (Vaccinium microcarpon) proanthocyanidins: isolation, identification, and bioactivities. J Agr Food Chem 59:3373-3384, 2011.
N. Pap, E. Pongrácz, M. Jaakkola, T. Tolonen, V. Virtanen, A. Turkki, Z. Horváth-Hovorka, G. Vatai, R. Keiski: The effect of pre-treatment on the anthocyanin and flavonol content of black currant juice (Ribes nigrum L.) in concentration by reverse osmosis. Journal of food engineering 98, 429-436, 2010.
M. Hämäläinen, R. Nieminen, P. Vuorela, M. Heinonen, E. Moilanen: The anti-inflammatory effects of flavonoids: Genistein, kaempferol, quercetin and daidzein inhibit STAT-1 and NF-kB activation whereas flavone, isorhamnetin, naringenin and pelargonidin inhibit only NF-kB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. Mediat Inflamm 2007:45673,2007.
S. Vuorela, K. Kreander, M. Karonen, R. Nieminen, M. Hämäläinen, A. Galkin, J.-P. Salminen, E. Moilanen, K. Pihlaja, H. Vuorela , P. Vuorela, M. Heinonen: Preclinic evaluation of rapeseed, raspberry and pine bark phenolics for health related effects. J Agric Food Chem 53:5922-5931, 2005.
M. Karonen, M. Hämäläinen, R. Nieminen, K. D. Klika, J. Loponen,V.V. Ovcharenko, E. Moilanen, K. Pihlaja: Phenolic extractives from the bark of Pinus sylvestris L. and their effects on inflammatory mediators nitric oxide and prostaglandin E2. J Agric FoodChem 52:7532-7540, 2004.
Patent: Backman, Josefin; Isohanni, Tiina; Jaakkola, Mari; Malinen, Hanna-Liisa; Mäki, Marianne; Räty, Jarkko; Virtanen, Vesa, Cosmetic compositions containing fractions of lingonberry extracts. Finnish Patent FI 124984 B Published 4/2015, European Patent EP2914242, Published 12/2017