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Computational Biophysics and Imaging Group

Publications

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Professor Hyttinen at Google Scholar

Pubmed

2024

  1. Subramaniyam, NP, Hyttinen, J. Sensitivity-analysis-guided Bayesian parameter estimation for neural mass models: Applications in epilepsy. Phys Rev E. 2024;110 (4-1):044208. doi: 10.1103/PhysRevE.110.044208. PubMed PMID:39562981 .
  2. Laguna-Castro, S, Salminen, A, Arponen, O, Hannula, M, Rinta-Kiikka, I, Hyttinen, J et al.. Micro-computed Tomography in the Evaluation of Eosin-stained Axillary Lymph Node Biopsies of Females Diagnosed with Breast Cancer. Sci Rep. 2024;14 (1):28237. doi: 10.1038/s41598-024-79060-4. PubMed PMID:39548163 PubMed Central PMC11568233.
  3. Genocchi, B, Ahtiainen, A, Niemi, A, Barros, MT, Tanskanen, JMA, Lenk, K et al.. Astrocytes induce desynchronization and reduce predictability in neuron-astrocyte networks cultured on microelectrode arrays. R Soc Open Sci. 2024;11 (10):240839. doi: 10.1098/rsos.240839. PubMed PMID:39479242 PubMed Central PMC11521599.
  4. Ochoa, JÁ, Neuvonen, PS, Hyttinen, J, Viik, J, Eskelinen, AP. Are some neutral liners more neutral than others? An ex vivo morphological analysis of acetabular liners classified as “neutral”. Acta Orthop. 2024;95 :586-591. doi: 10.2340/17453674.2024.41946. PubMed PMID:39392408 PubMed Central PMC11468231.
  5. Ahtiainen, A, Genocchi, B, Subramaniyam, NP, Tanskanen, JMA, Rantamäki, T, Hyttinen, JAK et al.. Astrocytes facilitate gabazine-evoked electrophysiological hyperactivity and distinct biochemical responses in mature neuronal cultures. J Neurochem. 2024;168 (9):3076-3094. doi: 10.1111/jnc.16182. PubMed PMID:39001671 .
  6. Ahtiainen, A, Leydolph, L, Tanskanen, JMA, Hunold, A, Haueisen, J, Hyttinen, JAK et al.. Electric field temporal interference stimulation of neurons . Lab Chip. 2024;24 (16):3945-3957. doi: 10.1039/d4lc00224e. PubMed PMID:38994783 .
  7. Vuorenpää, H, Valtonen, J, Penttinen, K, Koskimäki, S, Hovinen, E, Ahola, A et al.. Gellan gum-gelatin based cardiac models support formation of cellular networks and functional cardiomyocytes. Cytotechnology. 2024;76 (4):483-502. doi: 10.1007/s10616-024-00630-5. PubMed PMID:38933872 PubMed Central PMC11196475.
  8. Kurki, A, Paakinaho, K, Hannula, M, Karjalainen, S, Kuismanen, K, Hyttinen, J et al.. Promoting cell proliferation and collagen production with ascorbic acid 2-phosphate-releasing poly(l-lactide-co-ε-caprolactone) membranes for treating pelvic organ prolapse. Regen Biomater. 2024;11 :rbae060. doi: 10.1093/rb/rbae060. PubMed PMID:38903561 PubMed Central PMC11187500.
  9. Forouzandehmehr, M, Paci, M, Hyttinen, J, Koivumäki, JT. In silico study of the mechanisms of hypoxia and contractile dysfunction during ischemia and reperfusion of hiPSC cardiomyocytes. Dis Model Mech. 2024;17 (4):. doi: 10.1242/dmm.050365. PubMed PMID:38516812 PubMed Central PMC11073514.
  10. Toivanen, J, Paldanius, A, Dekdouk, B, Candiani, V, Hänninen, A, Savolainen, T et al.. Simulation-based feasibility study of monitoring of intracerebral hemorrhages and detection of secondary hemorrhages using electrical impedance tomography. J Med Imaging (Bellingham). 2024;11 (1):014502. doi: 10.1117/1.JMI.11.1.014502. PubMed PMID:38299159 PubMed Central PMC10826852.
  11. Sartoneva, R, Paakinaho, K, Hannula, M, Kuismanen, K, Huhtala, H, Hyttinen, J et al.. Ascorbic Acid 2-Phosphate Releasing Supercritically Foamed Porous Poly-L-Lactide-Co-ε-Caprolactone Scaffold Enhances the Collagen Production of Human Vaginal Stromal Cells: A New Approach for Vaginal Tissue Engineering. Tissue Eng Regen Med. 2024;21 (1):81-96. doi: 10.1007/s13770-023-00603-3. PubMed PMID:37907765 PubMed Central PMC10764701.

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2023

  1. Tervonen, A, Korpela, S, Nymark, S, Hyttinen, J, Ihalainen, TO. The Effect of Substrate Stiffness on Elastic Force Transmission in the Epithelial Monolayers over Short Timescales. Cell Mol Bioeng. 2023;16 (5-6):475-495. doi: 10.1007/s12195-023-00772-0. PubMed PMID:38099211 PubMed Central PMC10716100.
  2. Belay, B, Figueiras, E, Hyttinen, J, Ahola, A. Multifocal optical projection microscopy enables label-free 3D measurement of cardiomyocyte cluster contractility. Sci Rep. 2023;13 (1):19788. doi: 10.1038/s41598-023-46510-4. PubMed PMID:37957157 PubMed Central PMC10643565.
  3. Sartoneva, R, Paakinaho, K, Hannula, M, Kuismanen, K, Huhtala, H, Hyttinen, J et al.. Ascorbic Acid 2-Phosphate Releasing Supercritically Foamed Porous Poly-L-Lactide-Co-ε-Caprolactone Scaffold Enhances the Collagen Production of Human Vaginal Stromal Cells: A New Approach for Vaginal Tissue Engineering. Tissue Eng Regen Med. 2024;21 (1):81-96. doi: 10.1007/s13770-023-00603-3. PubMed PMID:37907765PubMed Central PMC10764701.
  4. Suominen, S, Hyypijev, T, Venäläinen, M, Yrjänäinen, A, Vuorenpää, H, Lehti-Polojärvi, M et al.. Improvements in Maturity and Stability of 3D iPSC-Derived Hepatocyte-like Cell Cultures. Cells. 2023;12 (19):. doi: 10.3390/cells12192368. PubMed PMID:37830581 PubMed Central PMC10571736.
  5. Puustinen, S, Hyttinen, J, Elomaa, AP, Vrzáková, H. Hyperspectral placenta dataset: Hyperspectral image acquisition, annotations, and processing of biological tissues in microsurgical training. Data Brief. 2023;50 :109526. doi: 10.1016/j.dib.2023.109526. PubMed PMID:37691737 PubMed Central PMC10482730.
  6. Belay, B, Mäntylä, E, Maibohm, C, Silvestre, OF, Hyttinen, J, Nieder, JB et al.. Substrate microtopographies induce cellular alignment and affect nuclear force transduction. J Mech Behav Biomed Mater. 2023;146 :106069. doi: 10.1016/j.jmbbm.2023.106069. PubMed PMID:37586175 .
  7. Kerslake, R, Belay, B, Panfilov, S, Hall, M, Kyrou, I, Randeva, HS et al.. Transcriptional Landscape of 3D vs. 2D Ovarian Cancer Cell Models. Cancers (Basel). 2023;15 (13):. doi: 10.3390/cancers15133350. PubMed PMID:37444459 PubMed Central PMC10340606.
  8. Mäntylä, E, Montonen, T, Azzari, L, Mattola, S, Hannula, M, Vihinen-Ranta, M et al.. Iterative immunostaining combined with expansion microscopy and image processing reveals nanoscopic network organization of nuclear lamina. Mol Biol Cell. 2023;34 (9):br13. doi: 10.1091/mbc.E22-09-0448. PubMed PMID:37342871 PubMed Central PMC10398900.
  9. Puustinen, S, Vrzáková, H, Hyttinen, J, Rauramaa, T, Fält, P, Hauta-Kasari, M et al.. Hyperspectral Imaging in Brain Tumor Surgery-Evidence of Machine Learning-Based Performance. World Neurosurg. 2023;175 :e614-e635. doi: 10.1016/j.wneu.2023.03.149. PubMed PMID:37030483 .
  10. Ahtiainen, A, Annala, I, Rosenholm, M, Kohtala, S, Hyttinen, J, Tanskanen, JMA et al.. Ketamine reduces electrophysiological network activity in cortical neuron cultures already at sub-micromolar concentrations – Impact on TrkB-ERK1/2 signaling. Neuropharmacology. 2023;229 :109481. doi: 10.1016/j.neuropharm.2023.109481. PubMed PMID:36868403 .
  11. Hyttinen, JMT, Blasiak, J, Kaarniranta, K. Non-Coding RNAs Regulating Mitochondrial Functions and the Oxidative Stress Response as Putative Targets against Age-Related Macular Degeneration (AMD). Int J Mol Sci. 2023;24 (3):. doi: 10.3390/ijms24032636. PubMed PMID:36768958 PubMed Central PMC9917342.

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2022

  1. Forouzandehmehr, M, Paci, M, Koivumäki, JT, Hyttinen, J. Altered contractility in mutation-specific hypertrophic cardiomyopathy: A mechano-energetic study with pharmacological insights. Front Physiol. 2022;13 :1010786. doi: 10.3389/fphys.2022.1010786. PubMed PMID:36388127 PubMed Central PMC9659818.
  2. Barros, MT, Siljak, H, Mullen, P, Papadias, C, Hyttinen, J, Marchetti, N et al.. Objective Supervised Machine Learning-Based Classification and Inference of Biological Neuronal Networks. Molecules. 2022;27 (19):. doi: 10.3390/molecules27196256. PubMed PMID:36234792 PubMed Central PMC9573053.
  3. Virta, J, Hannula, M, Lindfors, K, Tamminen, I, Taavela, J, Huhtala, H et al.. Validation of the X-ray microtomography in the assessment of duodenal morphometry and surface area in celiac disease. Front Immunol. 2022;13 :945197. doi: 10.3389/fimmu.2022.945197. PubMed PMID:36211435 PubMed Central PMC9539806.
  4. Jokela, J, Peyton, AJ, Hyttinen, J, Dekdouk, B. A method for evaluating sensitivity of electromagnetic localization systems for wireless capsule endoscopes. Annu Int Conf IEEE Eng Med Biol Soc. 2022;2022 :4872-4876. doi: 10.1109/EMBC48229.2022.9871187. PubMed PMID:36083936 .
  5. Paldanius, A, Dekdouk, B, Toivanen, J, Kolehmainen, V, Hyttinen, J. Corrections to “Sensitivity Analysis Highlights the Importance of Accurate Head Models for Electrical Impedance Tomography Monitoring of Intracerebral Hemorrhagic Stroke”. IEEE Trans Biomed Eng. 2022;69 (7):2401. doi: 10.1109/TBME.2022.3171670. PubMed PMID:35714112 .
  6. Abe, S, Kouhia, R, Nikander, R, Narra, N, Hyttinen, J, Sievänen, H et al.. Effect of fall direction on the lower hip fracture risk in athletes with different loading histories: A finite element modeling study in multiple sideways fall configurations. Bone. 2022;158 :116351. doi: 10.1016/j.bone.2022.116351. PubMed PMID:35131487 .
  7. Halonen, S, Ovissi, A, Boyd, S, Kari, J, Kronström, K, Kosunen, J et al.. Humanliver and tumor bioimpedance measured with biopsy needle. Physiol Meas. 2022;43 (1):. doi: 10.1088/1361-6579/ac4d38. PubMed PMID:35051907 .
  8. Paldanius, A, Dekdouk, B, Toivanen, J, Kolehmainen, V, Hyttinen, J. Sensitivity Analysis Highlights the Importance of Accurate Head Models for Electrical Impedance Tomography Monitoring of Intracerebral Hemorrhagic Stroke. IEEE Trans Biomed Eng. 2022;69 (4):1491-1501. doi: 10.1109/TBME.2021.3120929. PubMed PMID:34665718 .

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2021

  1. Ciarpella, F, Zamfir, RG, Campanelli, A, Ren, E, Pedrotti, G, Bottani, E et al.. Murine cerebral organoids develop network of functional neurons and hippocampal brain region identity. iScience. 2021;24 (12):103438. doi: 10.1016/j.isci.2021.103438. PubMed PMID:34901791 PubMed Central PMC8640475.
  2. Ahtiainen, A, Genocchi, B, Tanskanen, JMA, Barros, MT, Hyttinen, JAK, Lenk, K et al.. Astrocytes Exhibit a Protective Role in Neuronal Firing Patterns under Chemically Induced Seizures in Neuron-Astrocyte Co-Cultures. Int J Mol Sci. 2021;22 (23):. doi: 10.3390/ijms222312770. PubMed PMID:34884577 PubMed Central PMC8657549.
  3. Forouzandehmehr, M, Koivumäki, JT, Hyttinen, J, Paci, M. A mathematical model of hiPSC cardiomyocytes electromechanics. Physiol Rep. 2021;9 (22):e15124. doi: 10.14814/phy2.15124. PubMed PMID:34825519 PubMed Central PMC8617339.
  4. Belay, B, Koivisto, JT, Parraga, J, Koskela, O, Montonen, T, Kellomäki, M et al.. Optical projection tomography as a quantitative tool for analysis of cell morphology and density in 3D hydrogels. Sci Rep. 2021;11 (1):6538. doi: 10.1038/s41598-021-85996-8. PubMed PMID:33753803 PubMed Central PMC7985381.
  5. Repo, M, Hannula, M, Taavela, J, Hyttinen, J, Isola, J, Hiltunen, P et al.. Iron Transporter Protein Expressions in Children with Celiac Disease. Nutrients. 2021;13 (3):. doi: 10.3390/nu13030776. PubMed PMID:33673530 PubMed Central PMC7997288.

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2020

  1. Tanskanen, JMA, Ahtiainen, A, Hyttinen, JAK. Toward Closed-Loop Electrical Stimulation of Neuronal Systems: A Review. Bioelectricity. 2020;2 (4):328-347. doi: 10.1089/bioe.2020.0028. PubMed PMID:34471853 PubMed Central PMC8370352.
  2. Kapucu, FE, Välkki, I, Mikkonen, JE, Leone, C, Lenk, K, Tanskanen, JMA et al.. Corrigendum: Spectral Entropy Based Neuronal Network Synchronization Analysis Based on Microelectrode Array Measurements. Front Comput Neurosci. 2020;14 :586506. doi: 10.3389/fncom.2020.586506. PubMed PMID:33250731 PubMed Central PMC7672043.
  3. Genocchi, B, Cunha, A, Jain, S, Hyttinen, J, Lenk, K, Ellingsrud, AJ et al.. Parametric exploration of cellular swelling in a computational model of cortical spreading depression. Annu Int Conf IEEE Eng Med Biol Soc. 2020;2020 :2491-2495. doi: 10.1109/EMBC44109.2020.9175306. PubMed PMID:33018512 .
  4. Tamminen, I, Lehto, K, Hannula, M, Ojansivu, M, Johansson, L, Kellomäki, M et al.. A tube-source X-ray microtomography approach for quantitative 3D microscopy of optically challenging cell-cultured samples. Commun Biol. 2020;3 (1):548. doi: 10.1038/s42003-020-01273-w. PubMed PMID:33009501 PubMed Central PMC7532209.
  5. Virta, J, Hannula, M, Tamminen, I, Lindfors, K, Kaukinen, K, Popp, A et al.. X-ray microtomography is a novel method for accurate evaluation of small-bowel mucosal morphology and surface area. Sci Rep. 2020;10 (1):13164. doi: 10.1038/s41598-020-69487-w. PubMed PMID:32753621 PubMed Central PMC7403326.
  6. Shah, D, Prajapati, C, Penttinen, K, Cherian, RM, Koivumäki, JT, Alexanova, A et al.. hiPSC-Derived Cardiomyocyte Model of LQT2 Syndrome Derived from Asymptomatic and Symptomatic Mutation Carriers Reproduces Clinical Differences in Aggregates but Not in Single Cells. Cells. 2020;9 (5):. doi: 10.3390/cells9051153. PubMed PMID:32392813 PubMed Central PMC7290503.
  7. Bartolucci, C, Passini, E, Hyttinen, J, Paci, M, Severi, S. Simulation of the Effects of Extracellular Calcium Changes Leads to a Novel Computational Model of Human Ventricular Action Potential With a Revised Calcium Handling. Front Physiol. 2020;11 :314. doi: 10.3389/fphys.2020.00314. PubMed PMID:32351400 PubMed Central PMC7174690.
  8. Paci, M, Passini, E, Klimas, A, Severi, S, Hyttinen, J, Rodriguez, B et al.. All-Optical Electrophysiology Refines Populations of In Silico Human iPSC-CMs for Drug Evaluation. Biophys J. 2020;118 (10):2596-2611. doi: 10.1016/j.bpj.2020.03.018. PubMed PMID:32298635 PubMed Central PMC7231889.
  9. Palmroth, A, Pitkänen, S, Hannula, M, Paakinaho, K, Hyttinen, J, Miettinen, S et al.. Evaluation of scaffold microstructure and comparison of cell seeding methods using micro-computed tomography-based tools. J R Soc Interface. 2020;17 (165):20200102. doi: 10.1098/rsif.2020.0102. PubMed PMID:32228403 PubMed Central PMC7211473.
  10. Lenk, K, Satuvuori, E, Lallouette, J, Ladrón-de-Guevara, A, Berry, H, Hyttinen, JAK et al.. A Computational Model of Interactions Between Neuronal and Astrocytic Networks: The Role of Astrocytes in the Stability of the Neuronal Firing Rate. Front Comput Neurosci. 2019;13 :92. doi: 10.3389/fncom.2019.00092. PubMed PMID:32038210 PubMed Central PMC6987305.
  11. Joutsen, A, Hautalahti, J, Jaatinen, E, Goebeler, S, Paldanius, A, Viik, J et al.. A device for measuring sternal bone connectivity using vibration analysis techniques. Proc Inst Mech Eng H. 2020;234 (1):81-90. doi: 10.1177/0954411919884802. PubMed PMID:31856673 .

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2019

  1. Lenk, K, Satuvuori, E, Lallouette, J, Ladrón-de-Guevara, A, Berry, H, Hyttinen, JAK et al.. A Computational Model of Interactions Between Neuronal and Astrocytic Networks: The Role of Astrocytes in the Stability of the Neuronal Firing Rate. Front Comput Neurosci. 2019;13 :92. doi: 10.3389/fncom.2019.00092. PubMed PMID:32038210 PubMed Central PMC6987305.
  2. Joutsen, A, Hautalahti, J, Jaatinen, E, Goebeler, S, Paldanius, A, Viik, J et al.. A device for measuring sternal bone connectivity using vibration analysis techniques. Proc Inst Mech Eng H. 2020;234 (1):81-90. doi: 10.1177/0954411919884802. PubMed PMID:31856673 .
  3. Koskela, O, Montonen, T, Belay, B, Figueiras, E, Pursiainen, S, Hyttinen, J et al.. Gaussian Light Model in Brightfield Optical Projection Tomography. Sci Rep. 2019;9 (1):13934. doi: 10.1038/s41598-019-50469-6. PubMed PMID:31558755 PubMed Central PMC6763473.
  4. Wang, X, Molino, BZ, Pitkänen, S, Ojansivu, M, Xu, C, Hannula, M et al.. 3D Scaffolds of Polycaprolactone/Copper-Doped Bioactive Glass: Architecture Engineering with Additive Manufacturing and Cellular Assessments in a Coculture of Bone Marrow Stem Cells and Endothelial Cells. ACS Biomater Sci Eng. 2019;5 (9):4496-4510. doi: 10.1021/acsbiomaterials.9b00105. PubMed PMID:33438415 .
  5. Caetano Dos Santos, FL, Michalek, IM, Laurila, K, Kaukinen, K, Hyttinen, J, Lindfors, K et al.. Automatic classification of IgA endomysial antibody test for celiac disease: a new method deploying machine learning. Sci Rep. 2019;9 (1):9217. doi: 10.1038/s41598-019-45679-x. PubMed PMID:31239486PubMed Central PMC6592927.
  6. Tomaskovic-Crook, E, Zhang, P, Ahtiainen, A, Kaisvuo, H, Lee, CY, Beirne, S et al.. Human Neural Tissues from Neural Stem Cells Using Conductive Biogel and Printed Polymer Microelectrode Arrays for 3D Electrical Stimulation. Adv Healthc Mater. 2019;8 (15):e1900425. doi: 10.1002/adhm.201900425. PubMed PMID:31168967 .
  7. Koivisto, JT, Gering, C, Karvinen, J, Maria Cherian, R, Belay, B, Hyttinen, J et al.. Mechanically Biomimetic Gelatin-Gellan Gum Hydrogels for 3D Culture of Beating Human Cardiomyocytes. ACS Appl Mater Interfaces. 2019;11 (23):20589-20602. doi: 10.1021/acsami.8b22343. PubMed PMID:31120238PubMed Central PMC6750838.
  8. Ylä-Outinen, L, Tanskanen, JMA, Kapucu, FE, Hyysalo, A, Hyttinen, JAK, Narkilahti, S et al.. Advances in Human Stem Cell-Derived Neuronal Cell Culturing and Analysis. Adv Neurobiol. 2019;22 :299-329. doi: 10.1007/978-3-030-11135-9_13. PubMed PMID:31073942 .
  9. Alarautalahti, V, Ragauskas, S, Hakkarainen, JJ, Uusitalo-Järvinen, H, Uusitalo, H, Hyttinen, J et al.. Viability of Mouse Retinal Explant Cultures Assessed by Preservation of Functionality and Morphology. Invest Ophthalmol Vis Sci. 2019;60 (6):1914-1927. doi: 10.1167/iovs.18-25156. PubMed PMID:31042799.
  10. Niinimäki, S, Narra, N, Härkönen, L, Abe, S, Nikander, R, Hyttinen, J et al.. Do bone geometric properties of the proximal femoral diaphysis reflect loading history, muscle properties, or body dimensions?. Am J Hum Biol. 2019;31 (4):e23246. doi: 10.1002/ajhb.23246. PubMed PMID:31004392 .
  11. Tervonen, A, Ihalainen, TO, Nymark, S, Hyttinen, J. Structural dynamics of tight junctions modulate the properties of the epithelial barrier. PLoS One. 2019;14 (4):e0214876. doi: 10.1371/journal.pone.0214876. PubMed PMID:30964903PubMed Central PMC6456171.
  12. Vuornos, K, Ojansivu, M, Koivisto, JT, Häkkänen, H, Belay, B, Montonen, T et al.. Bioactive glass ions induce efficient osteogenic differentiation of human adipose stem cells encapsulated in gellan gum and collagen type I hydrogels. Mater Sci Eng C Mater Biol Appl. 2019;99 :905-918. doi: 10.1016/j.msec.2019.02.035. PubMed PMID:30889765 .
  13. Koljonen, V, Koskela, O, Montonen, T, Rezaei, A, Belay, B, Figueiras, E et al.. A mathematical model and iterative inversion for fluorescent optical projection tomography. Phys Med Biol. 2019;64 (4):045017. doi: 10.1088/1361-6560/aafd63. PubMed PMID:30630144 .
  14. Hautalahti, J, Joutsen, A, Goebeler, S, Luukkaala, T, Khan, J, Hyttinen, J et al.. Vibration transmittance measures sternotomy stability – a preliminary study in human cadavers. J Cardiothorac Surg. 2019;14 (1):2. doi: 10.1186/s13019-018-0823-5. PubMed PMID:30616661 PubMed Central PMC6323770.
  15. Halonen, S, Kari, J, Ahonen, P, Kronström, K, Hyttinen, J. Real-Time Bioimpedance-Based Biopsy Needle Can Identify Tissue Type with High Spatial Accuracy. Ann Biomed Eng. 2019;47 (3):836-851. doi: 10.1007/s10439-018-02187-9. PubMed PMID:30565006 .
  16. Korkka, I, Viheriälä, T, Juuti-Uusitalo, K, Uusitalo-Järvinen, H, Skottman, H, Hyttinen, J et al.. Functional Voltage-Gated Calcium Channels Are Present in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium. Stem Cells Transl Med. 2019;8 (2):179-193. doi: 10.1002/sctm.18-0026. PubMed PMID:30394009 PubMed Central PMC6344904.

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2018

  1. Halonen, S, Kari, J, Ahonen, P, Kronström, K, Hyttinen, J. Real-Time Bioimpedance-Based Biopsy Needle Can Identify Tissue Type with High Spatial Accuracy. Ann Biomed Eng. 2019;47 (3):836-851. doi: 10.1007/s10439-018-02187-9. PubMed PMID:30565006 .
  2. Paci, M, Casini, S, Bellin, M, Hyttinen, J, Severi, S. Large-Scale Simulation of the Phenotypical Variability Induced by Loss-of-Function Long QT Mutations in Human Induced Pluripotent Stem Cell Cardiomyocytes. Int J Mol Sci. 2018;19 (11):. doi: 10.3390/ijms19113583. PubMed PMID:30428582 PubMed Central PMC6274824.
  3. Korkka, I, Viheriälä, T, Juuti-Uusitalo, K, Uusitalo-Järvinen, H, Skottman, H, Hyttinen, J et al.. Functional Voltage-Gated Calcium Channels Are Present in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium. Stem Cells Transl Med. 2019;8 (2):179-193. doi: 10.1002/sctm.18-0026. PubMed PMID:30394009 PubMed Central PMC6344904.
  4. Pihlman, H, Keränen, P, Paakinaho, K, Linden, J, Hannula, M, Manninen, IK et al.. Novel osteoconductive β-tricalcium phosphate/poly(L-lactide-co-e-caprolactone) scaffold for bone regeneration: a study in a rabbit calvarial defect. J Mater Sci Mater Med. 2018;29 (10):156. doi: 10.1007/s10856-018-6159-9. PubMed PMID:30298429 .
  5. Sartoneva, R, Kuismanen, K, Juntunen, M, Karjalainen, S, Hannula, M, Kyllönen, L et al.. Porous poly-l-lactide-co-ɛ-caprolactone scaffold: a novel biomaterial for vaginal tissue engineering. R Soc Open Sci. 2018;5 (8):180811. doi: 10.1098/rsos.180811. PubMed PMID:30225072 PubMed Central PMC6124079.
  6. Abu Khamidakh, AE, Rodriguez-Martinez, A, Kaarniranta, K, Kallioniemi, A, Skottman, H, Hyttinen, J et al.. Wound healing of human embryonic stem cell-derived retinal pigment epithelial cells is affected by maturation stage. Biomed Eng Online. 2018;17 (1):102. doi: 10.1186/s12938-018-0535-z. PubMed PMID:30064430 PubMed Central PMC6069779.
  7. Paci, M, Pölönen, RP, Cori, D, Penttinen, K, Aalto-Setälä, K, Severi, S et al.. Automatic Optimization of an in Silico Model of Human iPSC Derived Cardiomyocytes Recapitulating Calcium Handling Abnormalities. Front Physiol. 2018;9 :709. doi: 10.3389/fphys.2018.00709. PubMed PMID:29997516PubMed Central PMC6028769.
  8. Abe, S, Narra, N, Nikander, R, Hyttinen, J, Kouhia, R, Sievänen, H et al.. Impact loading history modulates hip fracture load and location: A finite element simulation study of the proximal femur in female athletes. J Biomech. 2018;76 :136-143. doi: 10.1016/j.jbiomech.2018.05.037. PubMed PMID:29921524 .
  9. Ojansivu, M, Johansson, L, Vanhatupa, S, Tamminen, I, Hannula, M, Hyttinen, J et al.. Knitted 3D Scaffolds of Polybutylene Succinate Support Human Mesenchymal Stem Cell Growth and Osteogenesis. Stem Cells Int. 2018;2018 :5928935. doi: 10.1155/2018/5928935. PubMed PMID:29853915 PubMed Central PMC5964421.
  10. Mäki, AJ, Verho, J, Kreutzer, J, Ryynänen, T, Rajan, D, Pekkanen-Mattila, M et al.. A Portable Microscale Cell Culture System with Indirect Temperature Control. SLAS Technol. 2018;23 (6):566-579. doi: 10.1177/2472630318768710. PubMed PMID:29723086 .
  11. Ribeiro, VP, Silva-Correia, J, Gonçalves, C, Pina, S, Radhouani, H, Montonen, T et al.. Rapidly responsive silk fibroin hydrogels as an artificial matrix for the programmed tumor cells death. PLoS One. 2018;13 (4):e0194441. doi: 10.1371/journal.pone.0194441. PubMed PMID:29617395 PubMed Central PMC5884513.
  12. Narra, N, Abe, S, Dimitrov, V, Nikander, R, Kouhia, R, Sievänen, H et al.. Ricci-flow based conformal mapping of the proximal femur to identify exercise loading effects. Sci Rep. 2018;8 (1):4823. doi: 10.1038/s41598-018-23248-y. PubMed PMID:29555952 PubMed Central PMC5859094.
  13. Kuismanen, K, Juntunen, M, Narra Girish, N, Tuominen, H, Huhtala, H, Nieminen, K et al.. Functional Outcome of Human Adipose Stem Cell Injections in Rat Anal Sphincter Acute Injury Model. Stem Cells Transl Med. 2018;7 (3):295-304. doi: 10.1002/sctm.17-0208. PubMed PMID:29383878 PubMed Central PMC5827744.

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