Skip to content
Computational Biophysics and Imaging Group

Publications

Google Scholar

Professor Hyttinen at Google Scholar

Pubmed

2023

  1. Mäntylä, E, Montonen, T, Azzari, L, Mattola, S, Hannula, M, Vihinen-Ranta, M et al.. Iterative immunostaining combined with expansion microscopy and image processing reveals nanoscopic network organization of nuclear lamina. Mol Biol Cell. 2023; :mbcE22090448. doi: 10.1091/mbc.E22-09-0448. PubMed PMID:37342871 .

Search PubMed

2022

  1. Forouzandehmehr, M, Paci, M, Koivumäki, JT, Hyttinen, J. Altered contractility in mutation-specific hypertrophic cardiomyopathy: A mechano-energetic in silico study with pharmacological insights. Front Physiol. 2022;13 :1010786. doi: 10.3389/fphys.2022.1010786. PubMed PMID:36388127 PubMed Central PMC9659818.
  2. Barros, MT, Siljak, H, Mullen, P, Papadias, C, Hyttinen, J, Marchetti, N et al.. Objective Supervised Machine Learning-Based Classification and Inference of Biological Neuronal Networks. Molecules. 2022;27 (19):. doi: 10.3390/molecules27196256. PubMed PMID:36234792 PubMed Central PMC9573053.
  3. Virta, J, Hannula, M, Lindfors, K, Tamminen, I, Taavela, J, Huhtala, H et al.. Validation of the X-ray microtomography in the assessment of duodenal morphometry and surface area in celiac disease. Front Immunol. 2022;13 :945197. doi: 10.3389/fimmu.2022.945197. PubMed PMID:36211435 PubMed Central PMC9539806.
  4. Jokela, J, Peyton, AJ, Hyttinen, J, Dekdouk, B. A method for evaluating sensitivity of electromagnetic localization systems for wireless capsule endoscopes. Annu Int Conf IEEE Eng Med Biol Soc. 2022;2022 :4872-4876. doi: 10.1109/EMBC48229.2022.9871187. PubMed PMID:36083936 .
  5. Paldanius, A, Dekdouk, B, Toivanen, J, Kolehmainen, V, Hyttinen, J. Corrections to “Sensitivity Analysis Highlights the Importance of Accurate Head Models for Electrical Impedance Tomography Monitoring of Intracerebral Hemorrhagic Stroke”. IEEE Trans Biomed Eng. 2022;69 (7):2401. doi: 10.1109/TBME.2022.3171670. PubMed PMID:35714112 .
  6. Abe, S, Kouhia, R, Nikander, R, Narra, N, Hyttinen, J, Sievänen, H et al.. Effect of fall direction on the lower hip fracture risk in athletes with different loading histories: A finite element modeling study in multiple sideways fall configurations. Bone. 2022;158 :116351. doi: 10.1016/j.bone.2022.116351. PubMed PMID:35131487 .
  7. Halonen, S, Ovissi, A, Boyd, S, Kari, J, Kronström, K, Kosunen, J et al.. Humanin vivoliver and tumor bioimpedance measured with biopsy needle. Physiol Meas. 2022;43 (1):. doi: 10.1088/1361-6579/ac4d38. PubMed PMID:35051907 .
  8. Paldanius, A, Dekdouk, B, Toivanen, J, Kolehmainen, V, Hyttinen, J. Sensitivity Analysis Highlights the Importance of Accurate Head Models for Electrical Impedance Tomography Monitoring of Intracerebral Hemorrhagic Stroke. IEEE Trans Biomed Eng. 2022;69 (4):1491-1501. doi: 10.1109/TBME.2021.3120929. PubMed PMID:34665718 .

Search PubMed

2021

  1. Ciarpella, F, Zamfir, RG, Campanelli, A, Ren, E, Pedrotti, G, Bottani, E et al.. Murine cerebral organoids develop network of functional neurons and hippocampal brain region identity. iScience. 2021;24 (12):103438. doi: 10.1016/j.isci.2021.103438. PubMed PMID:34901791 PubMed Central PMC8640475.
  2. Ahtiainen, A, Genocchi, B, Tanskanen, JMA, Barros, MT, Hyttinen, JAK, Lenk, K et al.. Astrocytes Exhibit a Protective Role in Neuronal Firing Patterns under Chemically Induced Seizures in Neuron-Astrocyte Co-Cultures. Int J Mol Sci. 2021;22 (23):. doi: 10.3390/ijms222312770. PubMed PMID:34884577 PubMed Central PMC8657549.
  3. Forouzandehmehr, M, Koivumäki, JT, Hyttinen, J, Paci, M. A mathematical model of hiPSC cardiomyocytes electromechanics. Physiol Rep. 2021;9 (22):e15124. doi: 10.14814/phy2.15124. PubMed PMID:34825519 PubMed Central PMC8617339.
  4. Belay, B, Koivisto, JT, Parraga, J, Koskela, O, Montonen, T, Kellomäki, M et al.. Optical projection tomography as a quantitative tool for analysis of cell morphology and density in 3D hydrogels. Sci Rep. 2021;11 (1):6538. doi: 10.1038/s41598-021-85996-8. PubMed PMID:33753803 PubMed Central PMC7985381.
  5. Repo, M, Hannula, M, Taavela, J, Hyttinen, J, Isola, J, Hiltunen, P et al.. Iron Transporter Protein Expressions in Children with Celiac Disease. Nutrients. 2021;13 (3):. doi: 10.3390/nu13030776. PubMed PMID:33673530 PubMed Central PMC7997288.

Search PubMed

2020

  1. Tanskanen, JMA, Ahtiainen, A, Hyttinen, JAK. Toward Closed-Loop Electrical Stimulation of Neuronal Systems: A Review. Bioelectricity. 2020;2 (4):328-347. doi: 10.1089/bioe.2020.0028. PubMed PMID:34471853 PubMed Central PMC8370352.
  2. Kapucu, FE, Välkki, I, Mikkonen, JE, Leone, C, Lenk, K, Tanskanen, JMA et al.. Corrigendum: Spectral Entropy Based Neuronal Network Synchronization Analysis Based on Microelectrode Array Measurements. Front Comput Neurosci. 2020;14 :586506. doi: 10.3389/fncom.2020.586506. PubMed PMID:33250731 PubMed Central PMC7672043.
  3. Genocchi, B, Cunha, A, Jain, S, Hyttinen, J, Lenk, K, Ellingsrud, AJ et al.. Parametric exploration of cellular swelling in a computational model of cortical spreading depression. Annu Int Conf IEEE Eng Med Biol Soc. 2020;2020 :2491-2495. doi: 10.1109/EMBC44109.2020.9175306. PubMed PMID:33018512 .
  4. Tamminen, I, Lehto, K, Hannula, M, Ojansivu, M, Johansson, L, Kellomäki, M et al.. A tube-source X-ray microtomography approach for quantitative 3D microscopy of optically challenging cell-cultured samples. Commun Biol. 2020;3 (1):548. doi: 10.1038/s42003-020-01273-w. PubMed PMID:33009501 PubMed Central PMC7532209.
  5. Virta, J, Hannula, M, Tamminen, I, Lindfors, K, Kaukinen, K, Popp, A et al.. X-ray microtomography is a novel method for accurate evaluation of small-bowel mucosal morphology and surface area. Sci Rep. 2020;10 (1):13164. doi: 10.1038/s41598-020-69487-w. PubMed PMID:32753621 PubMed Central PMC7403326.
  6. Shah, D, Prajapati, C, Penttinen, K, Cherian, RM, Koivumäki, JT, Alexanova, A et al.. hiPSC-Derived Cardiomyocyte Model of LQT2 Syndrome Derived from Asymptomatic and Symptomatic Mutation Carriers Reproduces Clinical Differences in Aggregates but Not in Single Cells. Cells. 2020;9 (5):. doi: 10.3390/cells9051153. PubMed PMID:32392813 PubMed Central PMC7290503.
  7. Bartolucci, C, Passini, E, Hyttinen, J, Paci, M, Severi, S. Simulation of the Effects of Extracellular Calcium Changes Leads to a Novel Computational Model of Human Ventricular Action Potential With a Revised Calcium Handling. Front Physiol. 2020;11 :314. doi: 10.3389/fphys.2020.00314. PubMed PMID:32351400 PubMed Central PMC7174690.
  8. Paci, M, Passini, E, Klimas, A, Severi, S, Hyttinen, J, Rodriguez, B et al.. All-Optical Electrophysiology Refines Populations of In Silico Human iPSC-CMs for Drug Evaluation. Biophys J. 2020;118 (10):2596-2611. doi: 10.1016/j.bpj.2020.03.018. PubMed PMID:32298635 PubMed Central PMC7231889.
  9. Palmroth, A, Pitkänen, S, Hannula, M, Paakinaho, K, Hyttinen, J, Miettinen, S et al.. Evaluation of scaffold microstructure and comparison of cell seeding methods using micro-computed tomography-based tools. J R Soc Interface. 2020;17 (165):20200102. doi: 10.1098/rsif.2020.0102. PubMed PMID:32228403 PubMed Central PMC7211473.
  10. Lenk, K, Satuvuori, E, Lallouette, J, Ladrón-de-Guevara, A, Berry, H, Hyttinen, JAK et al.. A Computational Model of Interactions Between Neuronal and Astrocytic Networks: The Role of Astrocytes in the Stability of the Neuronal Firing Rate. Front Comput Neurosci. 2019;13 :92. doi: 10.3389/fncom.2019.00092. PubMed PMID:32038210 PubMed Central PMC6987305.
  11. Joutsen, A, Hautalahti, J, Jaatinen, E, Goebeler, S, Paldanius, A, Viik, J et al.. A device for measuring sternal bone connectivity using vibration analysis techniques. Proc Inst Mech Eng H. 2020;234 (1):81-90. doi: 10.1177/0954411919884802. PubMed PMID:31856673 .

Search PubMed

2019

  1. Lenk, K, Satuvuori, E, Lallouette, J, Ladrón-de-Guevara, A, Berry, H, Hyttinen, JAK et al.. A Computational Model of Interactions Between Neuronal and Astrocytic Networks: The Role of Astrocytes in the Stability of the Neuronal Firing Rate. Front Comput Neurosci. 2019;13 :92. doi: 10.3389/fncom.2019.00092. PubMed PMID:32038210 PubMed Central PMC6987305.
  2. Joutsen, A, Hautalahti, J, Jaatinen, E, Goebeler, S, Paldanius, A, Viik, J et al.. A device for measuring sternal bone connectivity using vibration analysis techniques. Proc Inst Mech Eng H. 2020;234 (1):81-90. doi: 10.1177/0954411919884802. PubMed PMID:31856673 .
  3. Koskela, O, Montonen, T, Belay, B, Figueiras, E, Pursiainen, S, Hyttinen, J et al.. Gaussian Light Model in Brightfield Optical Projection Tomography. Sci Rep. 2019;9 (1):13934. doi: 10.1038/s41598-019-50469-6. PubMed PMID:31558755 PubMed Central PMC6763473.
  4. Wang, X, Molino, BZ, Pitkänen, S, Ojansivu, M, Xu, C, Hannula, M et al.. 3D Scaffolds of Polycaprolactone/Copper-Doped Bioactive Glass: Architecture Engineering with Additive Manufacturing and Cellular Assessments in a Coculture of Bone Marrow Stem Cells and Endothelial Cells. ACS Biomater Sci Eng. 2019;5 (9):4496-4510. doi: 10.1021/acsbiomaterials.9b00105. PubMed PMID:33438415 .
  5. Caetano Dos Santos, FL, Michalek, IM, Laurila, K, Kaukinen, K, Hyttinen, J, Lindfors, K et al.. Automatic classification of IgA endomysial antibody test for celiac disease: a new method deploying machine learning. Sci Rep. 2019;9 (1):9217. doi: 10.1038/s41598-019-45679-x. PubMed PMID:31239486PubMed Central PMC6592927.
  6. Tomaskovic-Crook, E, Zhang, P, Ahtiainen, A, Kaisvuo, H, Lee, CY, Beirne, S et al.. Human Neural Tissues from Neural Stem Cells Using Conductive Biogel and Printed Polymer Microelectrode Arrays for 3D Electrical Stimulation. Adv Healthc Mater. 2019;8 (15):e1900425. doi: 10.1002/adhm.201900425. PubMed PMID:31168967 .
  7. Koivisto, JT, Gering, C, Karvinen, J, Maria Cherian, R, Belay, B, Hyttinen, J et al.. Mechanically Biomimetic Gelatin-Gellan Gum Hydrogels for 3D Culture of Beating Human Cardiomyocytes. ACS Appl Mater Interfaces. 2019;11 (23):20589-20602. doi: 10.1021/acsami.8b22343. PubMed PMID:31120238PubMed Central PMC6750838.
  8. Ylä-Outinen, L, Tanskanen, JMA, Kapucu, FE, Hyysalo, A, Hyttinen, JAK, Narkilahti, S et al.. Advances in Human Stem Cell-Derived Neuronal Cell Culturing and Analysis. Adv Neurobiol. 2019;22 :299-329. doi: 10.1007/978-3-030-11135-9_13. PubMed PMID:31073942 .
  9. Alarautalahti, V, Ragauskas, S, Hakkarainen, JJ, Uusitalo-Järvinen, H, Uusitalo, H, Hyttinen, J et al.. Viability of Mouse Retinal Explant Cultures Assessed by Preservation of Functionality and Morphology. Invest Ophthalmol Vis Sci. 2019;60 (6):1914-1927. doi: 10.1167/iovs.18-25156. PubMed PMID:31042799.
  10. Niinimäki, S, Narra, N, Härkönen, L, Abe, S, Nikander, R, Hyttinen, J et al.. Do bone geometric properties of the proximal femoral diaphysis reflect loading history, muscle properties, or body dimensions?. Am J Hum Biol. 2019;31 (4):e23246. doi: 10.1002/ajhb.23246. PubMed PMID:31004392 .
  11. Tervonen, A, Ihalainen, TO, Nymark, S, Hyttinen, J. Structural dynamics of tight junctions modulate the properties of the epithelial barrier. PLoS One. 2019;14 (4):e0214876. doi: 10.1371/journal.pone.0214876. PubMed PMID:30964903PubMed Central PMC6456171.
  12. Vuornos, K, Ojansivu, M, Koivisto, JT, Häkkänen, H, Belay, B, Montonen, T et al.. Bioactive glass ions induce efficient osteogenic differentiation of human adipose stem cells encapsulated in gellan gum and collagen type I hydrogels. Mater Sci Eng C Mater Biol Appl. 2019;99 :905-918. doi: 10.1016/j.msec.2019.02.035. PubMed PMID:30889765 .
  13. Koljonen, V, Koskela, O, Montonen, T, Rezaei, A, Belay, B, Figueiras, E et al.. A mathematical model and iterative inversion for fluorescent optical projection tomography. Phys Med Biol. 2019;64 (4):045017. doi: 10.1088/1361-6560/aafd63. PubMed PMID:30630144 .
  14. Hautalahti, J, Joutsen, A, Goebeler, S, Luukkaala, T, Khan, J, Hyttinen, J et al.. Vibration transmittance measures sternotomy stability – a preliminary study in human cadavers. J Cardiothorac Surg. 2019;14 (1):2. doi: 10.1186/s13019-018-0823-5. PubMed PMID:30616661 PubMed Central PMC6323770.
  15. Halonen, S, Kari, J, Ahonen, P, Kronström, K, Hyttinen, J. Real-Time Bioimpedance-Based Biopsy Needle Can Identify Tissue Type with High Spatial Accuracy. Ann Biomed Eng. 2019;47 (3):836-851. doi: 10.1007/s10439-018-02187-9. PubMed PMID:30565006 .
  16. Korkka, I, Viheriälä, T, Juuti-Uusitalo, K, Uusitalo-Järvinen, H, Skottman, H, Hyttinen, J et al.. Functional Voltage-Gated Calcium Channels Are Present in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium. Stem Cells Transl Med. 2019;8 (2):179-193. doi: 10.1002/sctm.18-0026. PubMed PMID:30394009 PubMed Central PMC6344904.

Search PubMed

2018

  1. Halonen, S, Kari, J, Ahonen, P, Kronström, K, Hyttinen, J. Real-Time Bioimpedance-Based Biopsy Needle Can Identify Tissue Type with High Spatial Accuracy. Ann Biomed Eng. 2019;47 (3):836-851. doi: 10.1007/s10439-018-02187-9. PubMed PMID:30565006 .
  2. Paci, M, Casini, S, Bellin, M, Hyttinen, J, Severi, S. Large-Scale Simulation of the Phenotypical Variability Induced by Loss-of-Function Long QT Mutations in Human Induced Pluripotent Stem Cell Cardiomyocytes. Int J Mol Sci. 2018;19 (11):. doi: 10.3390/ijms19113583. PubMed PMID:30428582 PubMed Central PMC6274824.
  3. Korkka, I, Viheriälä, T, Juuti-Uusitalo, K, Uusitalo-Järvinen, H, Skottman, H, Hyttinen, J et al.. Functional Voltage-Gated Calcium Channels Are Present in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium. Stem Cells Transl Med. 2019;8 (2):179-193. doi: 10.1002/sctm.18-0026. PubMed PMID:30394009 PubMed Central PMC6344904.
  4. Pihlman, H, Keränen, P, Paakinaho, K, Linden, J, Hannula, M, Manninen, IK et al.. Novel osteoconductive β-tricalcium phosphate/poly(L-lactide-co-e-caprolactone) scaffold for bone regeneration: a study in a rabbit calvarial defect. J Mater Sci Mater Med. 2018;29 (10):156. doi: 10.1007/s10856-018-6159-9. PubMed PMID:30298429 .
  5. Sartoneva, R, Kuismanen, K, Juntunen, M, Karjalainen, S, Hannula, M, Kyllönen, L et al.. Porous poly-l-lactide-co-ɛ-caprolactone scaffold: a novel biomaterial for vaginal tissue engineering. R Soc Open Sci. 2018;5 (8):180811. doi: 10.1098/rsos.180811. PubMed PMID:30225072 PubMed Central PMC6124079.
  6. Abu Khamidakh, AE, Rodriguez-Martinez, A, Kaarniranta, K, Kallioniemi, A, Skottman, H, Hyttinen, J et al.. Wound healing of human embryonic stem cell-derived retinal pigment epithelial cells is affected by maturation stage. Biomed Eng Online. 2018;17 (1):102. doi: 10.1186/s12938-018-0535-z. PubMed PMID:30064430 PubMed Central PMC6069779.
  7. Paci, M, Pölönen, RP, Cori, D, Penttinen, K, Aalto-Setälä, K, Severi, S et al.. Automatic Optimization of an in Silico Model of Human iPSC Derived Cardiomyocytes Recapitulating Calcium Handling Abnormalities. Front Physiol. 2018;9 :709. doi: 10.3389/fphys.2018.00709. PubMed PMID:29997516PubMed Central PMC6028769.
  8. Abe, S, Narra, N, Nikander, R, Hyttinen, J, Kouhia, R, Sievänen, H et al.. Impact loading history modulates hip fracture load and location: A finite element simulation study of the proximal femur in female athletes. J Biomech. 2018;76 :136-143. doi: 10.1016/j.jbiomech.2018.05.037. PubMed PMID:29921524 .
  9. Ojansivu, M, Johansson, L, Vanhatupa, S, Tamminen, I, Hannula, M, Hyttinen, J et al.. Knitted 3D Scaffolds of Polybutylene Succinate Support Human Mesenchymal Stem Cell Growth and Osteogenesis. Stem Cells Int. 2018;2018 :5928935. doi: 10.1155/2018/5928935. PubMed PMID:29853915 PubMed Central PMC5964421.
  10. Mäki, AJ, Verho, J, Kreutzer, J, Ryynänen, T, Rajan, D, Pekkanen-Mattila, M et al.. A Portable Microscale Cell Culture System with Indirect Temperature Control. SLAS Technol. 2018;23 (6):566-579. doi: 10.1177/2472630318768710. PubMed PMID:29723086 .
  11. Ribeiro, VP, Silva-Correia, J, Gonçalves, C, Pina, S, Radhouani, H, Montonen, T et al.. Rapidly responsive silk fibroin hydrogels as an artificial matrix for the programmed tumor cells death. PLoS One. 2018;13 (4):e0194441. doi: 10.1371/journal.pone.0194441. PubMed PMID:29617395 PubMed Central PMC5884513.
  12. Narra, N, Abe, S, Dimitrov, V, Nikander, R, Kouhia, R, Sievänen, H et al.. Ricci-flow based conformal mapping of the proximal femur to identify exercise loading effects. Sci Rep. 2018;8 (1):4823. doi: 10.1038/s41598-018-23248-y. PubMed PMID:29555952 PubMed Central PMC5859094.
  13. Kuismanen, K, Juntunen, M, Narra Girish, N, Tuominen, H, Huhtala, H, Nieminen, K et al.. Functional Outcome of Human Adipose Stem Cell Injections in Rat Anal Sphincter Acute Injury Model. Stem Cells Transl Med. 2018;7 (3):295-304. doi: 10.1002/sctm.17-0208. PubMed PMID:29383878 PubMed Central PMC5827744.

Search PubMed