The paper recently published by Mohamadamin Forouzandehmehr and coworkers presents the first computational electromechanical model of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). Incorporating experimental variability, this model captures the essential action potential, calcium transients, mechanical biomarkers such as fractional cell shortening, active tension magnitude, relaxation kinetics, and the inotropic effects of non-cardiomyocytes (e.g. collagen) in hiPSC-CM tissues.
The paper is published in Physiological Reports:
A mathematical model of hiPSC cardiomyocytes electromechanicsMohamadamin Forouzandehmehr, Jussi T. Koivumäki, Jari Hyttinen, Michelangelo Paci