Selected publications

Here you can find the most central CoEBoC publications. For the most extensive list, please refer to the webpages of the research groups.

Publications 2024

Gellan gum-gelatin based cardiac models support formation of cellular networks and functional cardiomyocytes

Hanna Vuorenpää, Joona Valtonen, Kirsi Penttinen, Sanna Koskimäki, Emma Hovinen, Antti Ahola, Christine Gering, Jenny Parraga, Minna Kelloniemi, Jari Hyttinen, Minna Kellomäki, Katriina Aalto-Setälä, Susanna Miettinen & Mari Pekkanen-Mattila

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Synthesis and Characterization of PolyHIPE-Gellan Gum Material with Tunable Macroporosity for Tissue Engineering Applications

Sweeta Akbari, Mart Kroon, Vijay Singh Parihar, Janne T. Koivisto, Markus Hannula, Minna Kellomäki, and Jari Hyttinen

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Publications 2023

Ascorbic Acid 2-Phosphate-Releasing Supercritical Carbon Dioxide-Foamed Poly(L-Lactide-Co-epsilon-Caprolactone) Scaffolds Support Urothelial Cell Growth and Enhance Human Adipose-Derived Stromal Cell Proliferation and Collagen Production Journal of Tissue Engineering and Regenerative Medicine

Alma Kurki, Kaarlo Paakinaho, Markus Hannula, Jari Hyttinen, Susanna Miettinen, Reetta Sartoneva

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Customized inkjet-printed 3D in vitro microelectrode arrays for 3D cell models

Tomi Ryynänen, H Peng, AM Moilanen, I Kopic, M Mäntysalo, Susanna Narkilahti, B Wolfrum, P Kallio

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Oxygen gradient generator to improve in vitro modeling of ischemic stroke

EJ Santiago, J Kreutzer, E Bossink, P Kallio, J le Feber

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In vitro α–synuclein aggregation and propagation model: A microphysiological model for the temporal assessment of neuronla functionality during the PFF-seeded α–synuclein aggregation and its propagation

Emre Kapucu, Iisa Tujula, Oskari Kulta, Lassi Sukki, Valtteri Vuolanto, Andrey Vinogradov, Pasi Kallio, Susanna Narkilahti

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Simulation-Based Study of Control Strategies for Beating of Human Cardiomyocyte Cultures

Antti-Juhana Mäki, Jussi T Koivumäki, Jari Hyttinen, Pasi Kallio

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Human tripartite cortical network model for temporal assessment of alpha-synuclein aggregation and propagation in Parkinson’s Disease

Fikret Emre Kapucu, Iisa Tujula, Oskari Kulta, Lassi Sukki, Tomi Ryynänen, Hjalte Gram, Valtteri Vuolanto, Andrey Vinogradov, Joose Kreutzer, Poul Henning Jensen, Pasi Kallio, Susanna Narkilahti

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Toward Corneal Limbus In Vitro Model: Regulation of hPSC‐LSC Phenotype by Matrix Stiffness and Topography During Cell Differentiation Process

Maija Kauppila, Anni Mörö, Juan José Valle-Delgado, Teemu Ihalainen, Lassi Sukki, Paula Puistola, Pasi Kallio, Tanja Ilmarinen, Monika Österberg, Heli Skottman

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Gut-on-chip devices as intestinal inflammation models and their future for studying multifactorial diseases.

Susanne Taavitsainen, Kati Juuti-Uusitalo, Kalle Kurppa, Katri Lindfors, Pasi Kallio, Minna Kellomäki

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Improvements in Maturity and Stability of 3D iPSC-Derived Hepatocyte-like Cell Cultures.

Suominen, S, Hyypijev, T, Venäläinen, M, Yrjänäinen, A, Vuorenpää, H, Lehti-Polojärvi, M, Räsänen, M, Seppänen, M, Hyttinen, J, Miettinen, S, Aalto-Setälä, K, Viiri, L

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Substrate microtopographies induce cellular alignment and affect nuclear force transduction

Birhanu Belay, Elina Mäntylä, Christian Maibohm, Oscar F. Silvestre, Jari Hyttinen, Jana B. Nieder, Teemu O. Ihalainen

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Building blocks of microphysiological system to model physiology and pathophysiology of human heart

Hanna Vuorenpää, Miina Björninen, Hannu Välimäki, Antti Ahola, Mart Kroon, Laura Honkamäki, Jussi T. Koivumäki, Mari Pekkanen-Mattila

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Simultaneous induction of vasculature and neuronal network formation on a chip reveals a dynamic interrelationship between cell types

Lotta Isosaari, Hanna Vuorenpää, Alma Yrjänäinen, Fikret Emre Kapucu, Minna Kelloniemi, Toni-Karri Pakarinen, Susanna Miettinen & Susanna Narkilahti

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Heat Shock Protein 27 Is Involved in the Bioactive Glass Induced Osteogenic Response of Human Mesenchymal Stem Cells

Laura Hyväri, Sari Vanhatupa, Miina Ojansivu, Minna Kelloniemi, Toni-Karri Pakarinen, Leena Hupa and Susanna Miettinen

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Immunomodulatory Functions of Adipose Mesenchymal Stromal/Stem Cell Derived from Donors With Type 2 Diabetes and Obesity on CD4 T Cells

Marwa Mahmoud, Miia Juntunen, Amna Adnan, Laura Kummola, Ilkka S Junttila, Minna Kelloniemi, Tuula Tyrväinen, Heini Huhtala, Abeer I Abd El Fattah, Khalda Amr, Alaa Mohamad El erian, Mimmi Patrikoski and Susanna Miettinen

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Coronary artery disease patient‑derived iPSC‑hepatocytes have distinct miRNA profile that may alter lipid metabolism

Anna Alexanova , Emma Raitoharju , Joona Valtonen, Katriina Aalto‑Setälä & Leena E. Viiri

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Publications 2022

Sequential Cross-linking of Gallic Acid-Functionalized GelMA-Based Bioinks with Enhanced Printability for Extrusion-Based 3D Bioprinting

Hatai Jongprasitkul, Sanna Turunen,, Vijay Singh Parihar, Minna Kellomäki

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Bioactivated gellan gum hydrogels affect cellular rearrangement and cell response in vascular co-culture and subcutaneous implant models

Christine Gering, Jenny Párraga, Hanna Vuorenpää, Lucía Botero, Susanna Miettinen, Minna Kellomäki

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Altered contractility in mutation-specific hypertrophic cardiomyopathy: A mechano-energetic in silico study with pharmacological insights

Mohamadamin Forouzandehmehr, Michelangelo Paci, Jussi Koivumäki and Jari Hyttinen

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Characterization of self-healing hydrogels for biomedical applications

Jennika Karvinen, Minna Kellomäki

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Growth Response and Differentiation of Bone Marrow-Derived Mesenchymal Stem/Stromal Cells in the Presence of Novel Multiple Myeloma Drug Melflufen

Arjen Gebraad, Roope Ohlsbom, Juho J Miettinen, Promise Emeh, Toni-Karri Pakarinen, Mikko Manninen, Antti Eskelinen 6, Kirsi Kuismanen, Ana Slipicevic, Fredrik Lehmann, Nina N Nupponen, Caroline A Heckman, Susanna Miettinen

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Compartmentalized organ-on-a-chip structure for spatiotemporal control of oxygen microenvironments

Kaisa Tornberg , Hannu Välimäki, Silmu Valaskivi, Antti-Juhana Mäki, Matias Jokinen, Joose Kreutzer, Pasi Kallio

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A method to measure data complexity of a complicated medical data set

Martti Juhola, Henry Joutsijoki, Kirsi Penttinen, Disheet Shah, Katriina Aalto-Setälä

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Fluorescent hiPSC-derived MYH6-mScarlet cardiomyocytes for real-time tracking, imaging, and cardiotoxicity assays

Reeja Maria Cherian, Chandra Prajapati, Kirsi Penttinen, Martta Häkli, Janne T Koivisto, Mari Pekkanen-Mattila, Katriina Aalto-Setälä

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Samanta S, Ylä-Outinen L, Rangasami V, Narkilahti S and Oommen OP.

Bidirectional cell-matrix interaction dictates neuronal network formation in a brain mimetic 3D scaffold.

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Corrosion and Protection of Silicon Nitride Insulators in Microelectrode Array Applications.

Karttu A, Lahtonen K, Heikkilä J, Väliaho J, Narkilahti S, Lekkala J, Kallio P.

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Establishment of a human induced pluripotent stem cell line (TAUi008-A) derived from a multiple sclerosis patient.

Lotila J, Hyvärinen T, Skottman H, Airas L, Narkilahti S, Hagman S.

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Effect of cell culture media on extracellular vesicle secretion from mesenchymal stromal cells and neurons.

Karttunen J, Heiskanen M, Joki T, Hyysalo A, Navarro-Ferrandis V, Miettinen S, Narkilahti S, Asla Pitkänen

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Practical guide for preparation, computational reconstruction and analysis of 3D human neuronal networks in control and ischaemic conditions.

Noora Räsänen, Venla Harju, Tiina Joki, Susanna Narkilahti

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Comparative microelectrode array data of the functional development of hPSC-derived and rat neuronal networks

Fikret Emre Kapucu, Andrey Vinogradov, Tanja Hyvärinen, Laura Ylä-Outinen & Susanna Narkilahti

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Human Neurons Form Axon-Mediated Functional Connections with Human Cardiomyocytes in Compartmentalized Microfluidic Chip

Martta Häkli,Satu Jäntti,Tiina Joki,Lassi Sukki,Kaisa Tornberg, Katriina Aalto-Setälä, Pasi Kallio, Mari Pekkanen-Mattila and Susanna Narkilahti

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Cardiac Ischemia On-a-Chip: Antiarrhythmic Effect of Levosimendan on Ischemic Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Gaballah, M, Penttinen, K, Kreutzer, J, Mäki, AJ, Kallio, P, Aalto-Setälä, K

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A kainic acid-induced seizure model in human pluripotent stem cell-derived cortical neurons for studying the role of IL-6 in the functional activity

Ropafadzo Mzezewa, Johanna Lotila, Heikki Kiiski, Andrey Vinogradov, Fikret Emre Kapucu, Jukka Peltola, Sanna Hagman, Susanna Narkilahti

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Vasculogenic Potency of Bone Marrow- and Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells Results in Differing Vascular Network Phenotypes in a Microfluidic Chip

Anastasiia Mykuliak, Alma Yrjänäinen, Antti-Juhana Mäki, Gebraad, Lampela, Kääriäinen, Toni-Karri Pakarinen, Pasi Kallio, Susanna Miettinen, Hanna Vuorenpää

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Self-assembled cellulose nanofiber–carbon nanotube nanocomposite films with anisotropic conductivity

Anne Skogberg, Sanna Siljander, Antti-Juhana Mäki, Mari Honkanen, Alexander Efimov, Markus Hannula, Panu Lahtinen, Sampo Tuukkanen, Tomas Björkqvist and Pasi Kallio

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Microfabricated porous SU-8 membranes as innervation interfaces for hiPSC-neurons in microfluidic devices

T Salpavaara, T Joki, A Skogberg, M T Calejo, J Lekkala, S Narkilahti and P Kallio

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Data analytics for cardiac diseases

Martti Juhola, Henry Joutsijoki, Kirsi Penttinen, Disheet Shah, Risto-Pekka Pölönen, Katriina Aalto-Setälä

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Two-step crosslinking to enhance the printability of methacrylated gellan gum biomaterial ink for extrusion-based 3D bioprinting

Hatai Jongprasitkul, Sanna Turunen, Vijay Singh, Parihar, Minna Kellomäki

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Publications 2021

Human induced pluripotent stem cell-based platform for modeling cardiac ischemia

Martta Häkli, Joose Kreutzer, Antti-Juhana Mäki, Hannu Välimäki, Henna Lappi, Heini Huhtala, Pasi Kallio, Katriina Aalto-Setälä & Mari Pekkanen-Mattila

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Bidirectional cell-matrix interaction dictates neuronal network formation in a brain-mimetic 3D scaffold

Sumanta Samanta, Laura Ylä-Outinen, Vignesh Kumar, Rangasami, Susanna Narkilahti, Oommen P.Oommen

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A mathematical model of hiPSC cardiomyocytes electromechanics

Mohamadamin Forouzandehmehr, Jussi T. Koivumäki, Jari Hyttinen, Michelangelo Paci

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Astrocytes Exhibit a Protective Role in Neuronal Firing Patterns under Chemically Induced Seizures in Neuron–Astrocyte Co-Cultures

Annika Ahtiainen, Barbara Genocchi, Jarno M. A. Tanskanen, Michael T. Barros, Jari A. K. Hyttinen and Kerstin Lenk

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Sensitivity of the Human Ventricular BPS2020 Action Potential Model to the In Silico Mechanisms of Ischemia

Mohamadamin Forouzandehmehr, Chiara Bartolucci, Jari Hyttinen, Jussi T Koivumäki, Michelangelo Paci

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Multifrequency electrical impedance tomography in biological applications: A multimodal perspective

Mari Lehti-Polojärvi, Olli Koskela, Jari Hyttinen

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Optical Projection Tomography for Particle Counting and Morphology Analysis

Olli Koskela, Md Tanvirul Kabir Chowdhury, Toni Montonen, Birhanu Belay, Sampsa Pursiainen, Jari Hyttinen

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Analysis of Drug Effects on iPSC Cardiomyocytes with Machine Learning

Martti Juhola, Kirsi Penttinen, Henry Joutsijoki, Katriina Aalto-Setälä

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On computational classification of genetic cardiac diseases applying iPSC cardiomyocytes

Martti Juhola, Henry Joutsijoki, Kirsi Penttinen, Disheet Shah, Katriina Aalto-Setälä

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Electrophysiological evaluation of human induced pluripotent stem cell-derived cardiomyocytes obtained by different methods

Chandra Prajapati, Marisa Ojala, Henna Lappi, Katriina Aalto-Setälä, Mari Pekkanen-Mattila

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Retrieval of the conductivity spectrum of tissues in vitro with novel multimodal tomography

M Lehti-Polojärvi, M J Räsänen, L E Viiri, H Vuorenpää, S Miettinen, A Seppänen and J Hyttinen

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Evaluation of the effect of donor weight on adipose stromal/stem cell characteristics by using weight-discordant monozygotic twin pairs

Miia Juntunen, Sini Heinonen, Heini Huhtala, Aila Rissanen, Jaakko Kaprio, Kirsi Kuismanen, Kirsi H. Pietiläinen, Susanna Miettinen & Mimmi Patrikoski

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Chemical modification strategies for viscosity-dependent processing of gellan gum

Christine Gering, Anum Rasheed, Janne T. Koivisto, Jenny Párraga, Sampo Tuukkanen, Minna Kellomäki

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Comprehensive characterisation of the compressive behaviour of hydrogels using a new modelling procedure and redefining compression testing

Jairan Nafar Dastgerdi, Janne T.Koivisto, Olli Orell, Pantea Rava, Jarno Jokinenen, Mikko Kanerva, Minna Kellomäki

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Directional Growth of Human Neuronal Axons in a Microfluidic Device with Nanotopography on Azobenzene-Based Material

Mervi Ristola, Chiara Fedele, Sanna Hagman, Lassi Sukki, Fikret Emre Kapucu, Ropafadzo Mzezeva, Tanja Hyvärinen, Pasi Kallio, Arri Priimagi, Susanna Narkilahti.

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Optical projection tomography as a quantitative tool for analysis of cell morphology and density in 3D hydrogels

Birhanu Belay, Janne T Koivisto, Jenny Parraga, Olli Koskela, Toni Montonen, Minna Kellomäki, Edite Figueiras, Jari Hyttinen.

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Paci Michelangelo, Penttinen Kirsi, Pekkanen-Mattila Mari, Koivumäki Jussi T.

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Photocross-linkable Methacrylated Polypeptides and Polysaccharides for Casting, Injecting, and 3D Fabrication.

Hatai Jongprasitkul, Sanna Turunen, Vijay Singh Parihar, Shambhavee Annurakshita, and Minna Kellomäki

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Stem cell-based platform for modeling cardiac ischemia

Martta Häkli, Joose Kreutzer, Antti-Juhana Mäki, Hannu Välimäki, Henna Lappi, Heini Huhtala, Pasi Kallio, Katriina Aalto-Setälä & Mari Pekkanen-Mattila

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Electrophysiological evaluation of human induced pluripotent stem cell-derived cardiomyocytes obtained by different methods

Chandra Prajapati , Marisa Ojala, Henna Lappi, Katriina Aalto-Setälä, Mari Pekkanen-Mattila

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Publications 2020

hiPSC-Derived Cardiomyocyte Model of LQT2 Syndrome Derived from Asymptomatic and Symptomatic Mutation Carriers Reproduces Clinical Differences in Aggregates but Not in Single Cells.

Shah D, Prajapati C, Penttinen K, Cherian RM, Koivumäki JT, Alexanova A, Hyttinen J, Aalto-Setälä K

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Covalent immobilization of luminescent oxygen indicators reduces cytotoxicity

Välimäki H, Hyvärinen T, Leivo J, Iftikhar H, Pekkanen-Mattila M, Rajan DK, Verho J, Kreutzer J, Ryynänen T, Pirhonen J, Aalto-Setälä K, Kallio P, Narkilahti S, Lekkala J.

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Bioactive glass ions for in vitro osteogenesis and microvascularization in gellan gum-collagen hydrogels.

Vuornos K, Huhtala H, Kääriäinen M, Kuismanen K, Hupa L, Kellomäki M, Miettinen S

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Pneumatic unidirectional cell stretching device for mechanobiological studies of cardiomyocytes.

Kreutzer J, Viehrig M, Pölönen RP, Zhao F, Ojala M, Aalto-Setälä K, Kallio P.

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Transparent Microelectrode Arrays Fabricated by Ion Beam Assisted Deposition for Neuronal Cell in Vitro Recordings

Ryynänen T, Mzezewa R, Meriläinen E, Hyvärinen T, Lekkala J, Narkilahti S, Kallio P.

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