First ever computational model of engineered heart tissue electromechanics promotes the understanding of the underlying tissue physiology

The paper recently published by Mohamadamin Forouzandehmehr and coworkers presents the first computational electromechanical model of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). Incorporating experimental variability, this model captures the essential action potential, calcium transients, mechanical biomarkers such as fractional cell shortening, active tension magnitude, relaxation kinetics, and the inotropic effects of non-cardiomyocytes (e.g. collagen) in hiPSC-CM tissues.

The paper is published in Physiological Reports:
A mathematical model of hiPSC cardiomyocytes electromechanicsMohamadamin Forouzandehmehr, Jussi T. Koivumäki, Jari Hyttinen, Michelangelo Paci