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Centre of Excellence in Body on-Chip Research

New review article addressing arrhythmia mechanisms in human induced pluripotent stem cell–derived cardiomyocytes

Scope of the review. Although arrhythmogenic properties of hiPSC-CMs are very relevant in all 3 principal application fields (basic research, drug screening, and regenerative therapy), we focus on the first one and on the second one to a lesser extent. Also, we link the hiPSC-based findings to the human/patient context whenever possible.

Researchers of the Computational Biophysics & Imaging Group and the Heart group joined forces and wrote a review addressing arrhythmia mechanisms in human induced pluripotent stem cell–derived cardiomyocytes. The authors review the advances that the human induced pluripotent stem cell–based modeling systems have brought so far regarding the understanding of both arrhythmogenic triggers and substrates, while also briefly speculating the possibilities in the future.

This review article is again a nice example of the great multidisciplinary collaboration of CoEBoC.

Paci Michelangelo, Penttinen Kirsi, Pekkanen-Mattila Mari,  Koivumäki Jussi T.

Journal of Cardiovascular Pharmacology: March 2021 – Volume 77 – Issue 3 – p 300-316

doi: 10.1097/FJC.0000000000000972

 

https://journals.lww.com/cardiovascularpharm/Fulltext/2021/03000/Arrhythmia_Mechanisms_in_Human_Induced_Pluripotent.5.aspx