Selected publications

Here you can find the most central CoEBoC publications. For the most extensive list, please refer to the webpages of the research groups.

Selected publications 2025

An in vivo mimetic liver-lobule-chip (LLoC) for stem cell maturation, and zonation of hepatocyte-like cells on chip

Philip Dalsbecker, Siiri Suominen, Muhammad Asim Faridi, Reza Mahdavi, Julia Johansson, Charlotte Hamngren Blomqvist, Mattias Goksör, Katriina Aalto-Setälä, Leena E. Viiri and Caroline B. Adiels

Full text of article An in vivo mimetic liver-lobule-chip (LLoC) for stem cell maturation, and zonation of hepatocyte-like cells on chip

Compartmentalized perfusion for temporal control of the chemical microenvironment of iPSC-derived cardiac cells†

Kaisa Tornberg, Wolfram Grötsch, Niina Ritari, Saara Haikka, Lassi Sukki, Katriina Aalto-Setälä, Mari Pekkanen-Mattila, Pasi Kallio

Full text of article Compartmentalized perfusion for temporal control of the chemical microenvironment of iPSC-derived cardiac cells†

Modeling neuroinflammatory interactions between microglia and astrocytes in a human iPSC-based coculture platform

Iisa Tujula, Tanja Hyvärinen, Johanna Lotila, Julia Rogal, Dimitrios Voulgaris, Lassi Sukki, Kaisa Tornberg, Katri Korpela, Henna Jäntti, Tarja Malm, Anna Herland, Pasi Kallio, Susanna Narkilahti & Sanna Hagman

Full text of article Modeling neuroinflammatory interactions between microglia and astrocytes in a human iPSC-based coculture platform

Effects of Bariatric Surgery-Related Weight Loss on the Characteristics, Metabolism, and Immunomodulation of Adipose Stromal/Stem Cells in a Follow-Up Study

Amna Adnan, Miia Juntunen, Tuula Tyrväinen, Minna Kelloniemi, Laura Kummola, Reija Autio, Mimmi Patrikoski, Susanna Miettinen

Full text of article Effects of Bariatric Surgery-Related Weight Loss on the Characteristics, Metabolism, and Immunomodulation of Adipose Stromal/Stem Cells in a Follow-Up Study

Selected publications 2024

Functional 3D Human Neuron–Glioblastoma Model Reveals Cellular Interactions Enabling Drug Safety Assessments

Nanna Förster, Lotta Isosaari, Oskari Kulta, Oona Junnila, Valtteri Vuolanto, Marjukka Pollari, Kirsi J. Rautajoki, Susanna Narkilahti

Full text of article Functional 3D Human Neuron–Glioblastoma Model Reveals Cellular Interactions Enabling Drug Safety Assessments

Hyaluronic Acid-Based 3D Bioprinted Hydrogel Structure for Directed Axonal Guidance and Modeling Innervation In Vitro

Laura Honkamäki, Oskari Kulta, Paula Puistola, Karoliina Hopia, Promise Emeh, Lotta Isosaari, Anni Mörö, Susanna Narkilahti

Full text of article Hyaluronic Acid-Based 3D Bioprinted Hydrogel Structure for Directed Axonal Guidance and Modeling Innervation In Vitro

Barrier-free, open-top microfluidic chip for generating two distinct, interconnected 3D microvascular networks

Alma Yrjänäinen, Elina Mesiä, Ella Lampela, Joose Kreutzer, Jorma Vihinen, Kaisa Tornberg, Hanna Vuorenpää, Susanna Miettinen, Pasi Kallio & Antti-Juhana Mäki

Full text of article Barrier-free, open-top microfluidic chip for generating two distinct, interconnected 3D microvascular networks

Exploring Kainic Acid-Induced Alterations in Circular Tripartite Networks with Advanced Analysis Tools

Andrey Vinogradov, Emre Fikret Kapucu and Susanna Narkilahti

Full text of article Exploring Kainic Acid-Induced Alterations in Circular Tripartite Networks with Advanced Analysis Tools

Human tripartite cortical network model for temporal assessment of alpha-synuclein aggregation and propagation in Parkinson’s Disease

Fikret Emre Kapucu, Iisa Tujula, Oskari Kulta, Lassi Sukki, Tomi Ryynänen, Hjalte Gram, Valtteri Vuolanto, Andrey Vinogradov, Joose Kreutzer, Poul Henning Jensen, Pasi Kallio & Susanna Narkilahti

Full text of article Human tripartite cortical network model for temporal assessment of alpha-synuclein aggregation and propagation in Parkinson’s Disease

Synthesis and Characterization of PolyHIPE-Gellan Gum Material with Tunable Macroporosity for Tissue Engineering Applications

Sweeta Akbari, Mart Kroon, Vijay Singh Parihar, Janne T. Koivisto, Markus Hannula, Minna Kellomäki, and Jari Hyttinen

Full text of article Synthesis and Characterization of PolyHIPE-Gellan Gum Material with Tunable Macroporosity for Tissue Engineering Applications

In silico study of the mechanisms of hypoxia and contractile dysfunction during ischemia and reperfusion of hiPSC cardiomyocytes

Mohamadamin Forouzandehmehr, Michelangelo Paci, Jari Hyttinen, Jussi T. Koivumäki

Full text of article In silico study of the mechanisms of hypoxia and contractile dysfunction during ischemia and reperfusion of hiPSC cardiomyocytes

Gellan gum-gelatin based cardiac models support formation of cellular networks and functional cardiomyocytes

Hanna Vuorenpää, Joona Valtonen, Kirsi Penttinen, Sanna Koskimäki, Emma Hovinen, Antti Ahola, Christine Gering, Jenny Parraga, Minna Kelloniemi, Jari Hyttinen, Minna Kellomäki, Katriina Aalto-Setälä, Susanna Miettinen & Mari Pekkanen-Mattila

Full text of article Gellan gum-gelatin based cardiac models support formation of cellular networks and functional cardiomyocytes

Publications 2023

Ascorbic Acid 2-Phosphate-Releasing Supercritical Carbon Dioxide-Foamed Poly(L-Lactide-Co-epsilon-Caprolactone) Scaffolds Support Urothelial Cell Growth and Enhance Human Adipose-Derived Stromal Cell Proliferation and Collagen Production Journal of Tissue Engineering and Regenerative Medicine

Alma Kurki, Kaarlo Paakinaho, Markus Hannula, Jari Hyttinen, Susanna Miettinen, Reetta Sartoneva

Full text of article Ascorbic Acid 2-Phosphate-Releasing Supercritical Carbon Dioxide-Foamed Poly(L-Lactide-Co-epsilon-Caprolactone) Scaffolds Support Urothelial Cell Growth and Enhance Human Adipose-Derived Stromal Cell Proliferation and Collagen Production Journal of Tissue Engineering and Regenerative Medicine

Customized inkjet-printed 3D in vitro microelectrode arrays for 3D cell models

Tomi Ryynänen, H Peng, AM Moilanen, I Kopic, M Mäntysalo, Susanna Narkilahti, B Wolfrum, P Kallio

Full text of article Customized inkjet-printed 3D in vitro microelectrode arrays for 3D cell models

Oxygen gradient generator to improve in vitro modeling of ischemic stroke

EJ Santiago, J Kreutzer, E Bossink, P Kallio, J le Feber

Full text of article Oxygen gradient generator to improve in vitro modeling of ischemic stroke

In vitro α–synuclein aggregation and propagation model: A microphysiological model for the temporal assessment of neuronla functionality during the PFF-seeded α–synuclein aggregation and its propagation

Emre Kapucu, Iisa Tujula, Oskari Kulta, Lassi Sukki, Valtteri Vuolanto, Andrey Vinogradov, Pasi Kallio, Susanna Narkilahti

Full text of article In vitro α–synuclein aggregation and propagation model: A microphysiological model for the temporal assessment of neuronla functionality during the PFF-seeded α–synuclein aggregation and its propagation

Simulation-Based Study of Control Strategies for Beating of Human Cardiomyocyte Cultures

Antti-Juhana Mäki, Jussi T Koivumäki, Jari Hyttinen, Pasi Kallio

Full text of article Simulation-Based Study of Control Strategies for Beating of Human Cardiomyocyte Cultures

Human tripartite cortical network model for temporal assessment of alpha-synuclein aggregation and propagation in Parkinson’s Disease

Fikret Emre Kapucu, Iisa Tujula, Oskari Kulta, Lassi Sukki, Tomi Ryynänen, Hjalte Gram, Valtteri Vuolanto, Andrey Vinogradov, Joose Kreutzer, Poul Henning Jensen, Pasi Kallio, Susanna Narkilahti

Full text of article Human tripartite cortical network model for temporal assessment of alpha-synuclein aggregation and propagation in Parkinson’s Disease

Toward Corneal Limbus In Vitro Model: Regulation of hPSC‐LSC Phenotype by Matrix Stiffness and Topography During Cell Differentiation Process

Maija Kauppila, Anni Mörö, Juan José Valle-Delgado, Teemu Ihalainen, Lassi Sukki, Paula Puistola, Pasi Kallio, Tanja Ilmarinen, Monika Österberg, Heli Skottman

Full text of article Toward Corneal Limbus In Vitro Model: Regulation of hPSC‐LSC Phenotype by Matrix Stiffness and Topography During Cell Differentiation Process

Gut-on-chip devices as intestinal inflammation models and their future for studying multifactorial diseases.

Susanne Taavitsainen, Kati Juuti-Uusitalo, Kalle Kurppa, Katri Lindfors, Pasi Kallio, Minna Kellomäki

Full text of article Gut-on-chip devices as intestinal inflammation models and their future for studying multifactorial diseases.

Improvements in Maturity and Stability of 3D iPSC-Derived Hepatocyte-like Cell Cultures.

Suominen, S, Hyypijev, T, Venäläinen, M, Yrjänäinen, A, Vuorenpää, H, Lehti-Polojärvi, M, Räsänen, M, Seppänen, M, Hyttinen, J, Miettinen, S, Aalto-Setälä, K, Viiri, L

Full text of article Improvements in Maturity and Stability of 3D iPSC-Derived Hepatocyte-like Cell Cultures.

Substrate microtopographies induce cellular alignment and affect nuclear force transduction

Birhanu Belay, Elina Mäntylä, Christian Maibohm, Oscar F. Silvestre, Jari Hyttinen, Jana B. Nieder, Teemu O. Ihalainen

Full text of article Substrate microtopographies induce cellular alignment and affect nuclear force transduction

Building blocks of microphysiological system to model physiology and pathophysiology of human heart

Hanna Vuorenpää, Miina Björninen, Hannu Välimäki, Antti Ahola, Mart Kroon, Laura Honkamäki, Jussi T. Koivumäki, Mari Pekkanen-Mattila

Full text of article Building blocks of microphysiological system to model physiology and pathophysiology of human heart

Simultaneous induction of vasculature and neuronal network formation on a chip reveals a dynamic interrelationship between cell types

Lotta Isosaari, Hanna Vuorenpää, Alma Yrjänäinen, Fikret Emre Kapucu, Minna Kelloniemi, Toni-Karri Pakarinen, Susanna Miettinen & Susanna Narkilahti

Full text of article Simultaneous induction of vasculature and neuronal network formation on a chip reveals a dynamic interrelationship between cell types

Heat Shock Protein 27 Is Involved in the Bioactive Glass Induced Osteogenic Response of Human Mesenchymal Stem Cells

Laura Hyväri, Sari Vanhatupa, Miina Ojansivu, Minna Kelloniemi, Toni-Karri Pakarinen, Leena Hupa and Susanna Miettinen

Full text of article Heat Shock Protein 27 Is Involved in the Bioactive Glass Induced Osteogenic Response of Human Mesenchymal Stem Cells

Immunomodulatory Functions of Adipose Mesenchymal Stromal/Stem Cell Derived from Donors With Type 2 Diabetes and Obesity on CD4 T Cells

Marwa Mahmoud, Miia Juntunen, Amna Adnan, Laura Kummola, Ilkka S Junttila, Minna Kelloniemi, Tuula Tyrväinen, Heini Huhtala, Abeer I Abd El Fattah, Khalda Amr, Alaa Mohamad El erian, Mimmi Patrikoski and Susanna Miettinen

Full text of article Immunomodulatory Functions of Adipose Mesenchymal Stromal/Stem Cell Derived from Donors With Type 2 Diabetes and Obesity on CD4 T Cells

Coronary artery disease patient‑derived iPSC‑hepatocytes have distinct miRNA profile that may alter lipid metabolism

Anna Alexanova , Emma Raitoharju , Joona Valtonen, Katriina Aalto‑Setälä & Leena E. Viiri

Full text of article Coronary artery disease patient‑derived iPSC‑hepatocytes have distinct miRNA profile that may alter lipid metabolism

Publications 2022

Sequential Cross-linking of Gallic Acid-Functionalized GelMA-Based Bioinks with Enhanced Printability for Extrusion-Based 3D Bioprinting

Hatai Jongprasitkul, Sanna Turunen,, Vijay Singh Parihar, Minna Kellomäki

Full text of article Sequential Cross-linking of Gallic Acid-Functionalized GelMA-Based Bioinks with Enhanced Printability for Extrusion-Based 3D Bioprinting

Bioactivated gellan gum hydrogels affect cellular rearrangement and cell response in vascular co-culture and subcutaneous implant models

Christine Gering, Jenny Párraga, Hanna Vuorenpää, Lucía Botero, Susanna Miettinen, Minna Kellomäki

Full text of article Bioactivated gellan gum hydrogels affect cellular rearrangement and cell response in vascular co-culture and subcutaneous implant models

Altered contractility in mutation-specific hypertrophic cardiomyopathy: A mechano-energetic in silico study with pharmacological insights

Mohamadamin Forouzandehmehr, Michelangelo Paci, Jussi Koivumäki and Jari Hyttinen

Full text of article Altered contractility in mutation-specific hypertrophic cardiomyopathy: A mechano-energetic in silico study with pharmacological insights

Characterization of self-healing hydrogels for biomedical applications

Jennika Karvinen, Minna Kellomäki

Full text of article Characterization of self-healing hydrogels for biomedical applications

Growth Response and Differentiation of Bone Marrow-Derived Mesenchymal Stem/Stromal Cells in the Presence of Novel Multiple Myeloma Drug Melflufen

Arjen Gebraad, Roope Ohlsbom, Juho J Miettinen, Promise Emeh, Toni-Karri Pakarinen, Mikko Manninen, Antti Eskelinen 6, Kirsi Kuismanen, Ana Slipicevic, Fredrik Lehmann, Nina N Nupponen, Caroline A Heckman, Susanna Miettinen

Full text of article Growth Response and Differentiation of Bone Marrow-Derived Mesenchymal Stem/Stromal Cells in the Presence of Novel Multiple Myeloma Drug Melflufen

Compartmentalized organ-on-a-chip structure for spatiotemporal control of oxygen microenvironments

Kaisa Tornberg , Hannu Välimäki, Silmu Valaskivi, Antti-Juhana Mäki, Matias Jokinen, Joose Kreutzer, Pasi Kallio

Full text of article Compartmentalized organ-on-a-chip structure for spatiotemporal control of oxygen microenvironments

A method to measure data complexity of a complicated medical data set

Martti Juhola, Henry Joutsijoki, Kirsi Penttinen, Disheet Shah, Katriina Aalto-Setälä

Full text of article A method to measure data complexity of a complicated medical data set

Fluorescent hiPSC-derived MYH6-mScarlet cardiomyocytes for real-time tracking, imaging, and cardiotoxicity assays

Reeja Maria Cherian, Chandra Prajapati, Kirsi Penttinen, Martta Häkli, Janne T Koivisto, Mari Pekkanen-Mattila, Katriina Aalto-Setälä

Full text of article Fluorescent hiPSC-derived MYH6-mScarlet cardiomyocytes for real-time tracking, imaging, and cardiotoxicity assays

Samanta S, Ylä-Outinen L, Rangasami V, Narkilahti S and Oommen OP.

Bidirectional cell-matrix interaction dictates neuronal network formation in a brain mimetic 3D scaffold.

Full text of article Samanta S, Ylä-Outinen L, Rangasami V, Narkilahti S and Oommen OP.

Corrosion and Protection of Silicon Nitride Insulators in Microelectrode Array Applications.

Karttu A, Lahtonen K, Heikkilä J, Väliaho J, Narkilahti S, Lekkala J, Kallio P.

Full text of article Corrosion and Protection of Silicon Nitride Insulators in Microelectrode Array Applications.

Establishment of a human induced pluripotent stem cell line (TAUi008-A) derived from a multiple sclerosis patient.

Lotila J, Hyvärinen T, Skottman H, Airas L, Narkilahti S, Hagman S.

Full text of article Establishment of a human induced pluripotent stem cell line (TAUi008-A) derived from a multiple sclerosis patient.

Effect of cell culture media on extracellular vesicle secretion from mesenchymal stromal cells and neurons.

Karttunen J, Heiskanen M, Joki T, Hyysalo A, Navarro-Ferrandis V, Miettinen S, Narkilahti S, Asla Pitkänen

Full text of article Effect of cell culture media on extracellular vesicle secretion from mesenchymal stromal cells and neurons.

Practical guide for preparation, computational reconstruction and analysis of 3D human neuronal networks in control and ischaemic conditions.

Noora Räsänen, Venla Harju, Tiina Joki, Susanna Narkilahti

Full text of article Practical guide for preparation, computational reconstruction and analysis of 3D human neuronal networks in control and ischaemic conditions.

Comparative microelectrode array data of the functional development of hPSC-derived and rat neuronal networks

Fikret Emre Kapucu, Andrey Vinogradov, Tanja Hyvärinen, Laura Ylä-Outinen & Susanna Narkilahti

Full text and data set of article Comparative microelectrode array data of the functional development of hPSC-derived and rat neuronal networks

Human Neurons Form Axon-Mediated Functional Connections with Human Cardiomyocytes in Compartmentalized Microfluidic Chip

Martta Häkli,Satu Jäntti,Tiina Joki,Lassi Sukki,Kaisa Tornberg, Katriina Aalto-Setälä, Pasi Kallio, Mari Pekkanen-Mattila and Susanna Narkilahti

Full text of article Human Neurons Form Axon-Mediated Functional Connections with Human Cardiomyocytes in Compartmentalized Microfluidic Chip

Cardiac Ischemia On-a-Chip: Antiarrhythmic Effect of Levosimendan on Ischemic Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Gaballah, M, Penttinen, K, Kreutzer, J, Mäki, AJ, Kallio, P, Aalto-Setälä, K

Full text of article Cardiac Ischemia On-a-Chip: Antiarrhythmic Effect of Levosimendan on Ischemic Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

A kainic acid-induced seizure model in human pluripotent stem cell-derived cortical neurons for studying the role of IL-6 in the functional activity

Ropafadzo Mzezewa, Johanna Lotila, Heikki Kiiski, Andrey Vinogradov, Fikret Emre Kapucu, Jukka Peltola, Sanna Hagman, Susanna Narkilahti

Full text of article A kainic acid-induced seizure model in human pluripotent stem cell-derived cortical neurons for studying the role of IL-6 in the functional activity

Vasculogenic Potency of Bone Marrow- and Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells Results in Differing Vascular Network Phenotypes in a Microfluidic Chip

Anastasiia Mykuliak, Alma Yrjänäinen, Antti-Juhana Mäki, Gebraad, Lampela, Kääriäinen, Toni-Karri Pakarinen, Pasi Kallio, Susanna Miettinen, Hanna Vuorenpää

Full text of article Vasculogenic Potency of Bone Marrow- and Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells Results in Differing Vascular Network Phenotypes in a Microfluidic Chip

Self-assembled cellulose nanofiber–carbon nanotube nanocomposite films with anisotropic conductivity

Anne Skogberg, Sanna Siljander, Antti-Juhana Mäki, Mari Honkanen, Alexander Efimov, Markus Hannula, Panu Lahtinen, Sampo Tuukkanen, Tomas Björkqvist and Pasi Kallio

Full text of article Self-assembled cellulose nanofiber–carbon nanotube nanocomposite films with anisotropic conductivity

Microfabricated porous SU-8 membranes as innervation interfaces for hiPSC-neurons in microfluidic devices

T Salpavaara, T Joki, A Skogberg, M T Calejo, J Lekkala, S Narkilahti and P Kallio

Full text of article Microfabricated porous SU-8 membranes as innervation interfaces for hiPSC-neurons in microfluidic devices

Data analytics for cardiac diseases

Martti Juhola, Henry Joutsijoki, Kirsi Penttinen, Disheet Shah, Risto-Pekka Pölönen, Katriina Aalto-Setälä

Full text of article Data analytics for cardiac diseases

Two-step crosslinking to enhance the printability of methacrylated gellan gum biomaterial ink for extrusion-based 3D bioprinting

Hatai Jongprasitkul, Sanna Turunen, Vijay Singh, Parihar, Minna Kellomäki

Full text of article Two-step crosslinking to enhance the printability of methacrylated gellan gum biomaterial ink for extrusion-based 3D bioprinting

Publications 2021

Human induced pluripotent stem cell-based platform for modeling cardiac ischemia

Martta Häkli, Joose Kreutzer, Antti-Juhana Mäki, Hannu Välimäki, Henna Lappi, Heini Huhtala, Pasi Kallio, Katriina Aalto-Setälä & Mari Pekkanen-Mattila

Full text of article Human induced pluripotent stem cell-based platform for modeling cardiac ischemia

Bidirectional cell-matrix interaction dictates neuronal network formation in a brain-mimetic 3D scaffold

Sumanta Samanta, Laura Ylä-Outinen, Vignesh Kumar, Rangasami, Susanna Narkilahti, Oommen P.Oommen

Full text of article Bidirectional cell-matrix interaction dictates neuronal network formation in a brain-mimetic 3D scaffold

A mathematical model of hiPSC cardiomyocytes electromechanics

Mohamadamin Forouzandehmehr, Jussi T. Koivumäki, Jari Hyttinen, Michelangelo Paci

Full text of article A mathematical model of hiPSC cardiomyocytes electromechanics

Astrocytes Exhibit a Protective Role in Neuronal Firing Patterns under Chemically Induced Seizures in Neuron–Astrocyte Co-Cultures

Annika Ahtiainen, Barbara Genocchi, Jarno M. A. Tanskanen, Michael T. Barros, Jari A. K. Hyttinen and Kerstin Lenk

Full text of article Astrocytes Exhibit a Protective Role in Neuronal Firing Patterns under Chemically Induced Seizures in Neuron–Astrocyte Co-Cultures

Sensitivity of the Human Ventricular BPS2020 Action Potential Model to the In Silico Mechanisms of Ischemia

Mohamadamin Forouzandehmehr, Chiara Bartolucci, Jari Hyttinen, Jussi T Koivumäki, Michelangelo Paci

Full text of article Sensitivity of the Human Ventricular BPS2020 Action Potential Model to the In Silico Mechanisms of Ischemia

Multifrequency electrical impedance tomography in biological applications: A multimodal perspective

Mari Lehti-Polojärvi, Olli Koskela, Jari Hyttinen

Full text of article Multifrequency electrical impedance tomography in biological applications: A multimodal perspective

Optical Projection Tomography for Particle Counting and Morphology Analysis

Olli Koskela, Md Tanvirul Kabir Chowdhury, Toni Montonen, Birhanu Belay, Sampsa Pursiainen, Jari Hyttinen

Full text of article Optical Projection Tomography for Particle Counting and Morphology Analysis

Analysis of Drug Effects on iPSC Cardiomyocytes with Machine Learning

Martti Juhola, Kirsi Penttinen, Henry Joutsijoki, Katriina Aalto-Setälä

Full text of article Analysis of Drug Effects on iPSC Cardiomyocytes with Machine Learning

On computational classification of genetic cardiac diseases applying iPSC cardiomyocytes

Martti Juhola, Henry Joutsijoki, Kirsi Penttinen, Disheet Shah, Katriina Aalto-Setälä

Full text of article On computational classification of genetic cardiac diseases applying iPSC cardiomyocytes

Electrophysiological evaluation of human induced pluripotent stem cell-derived cardiomyocytes obtained by different methods

Chandra Prajapati, Marisa Ojala, Henna Lappi, Katriina Aalto-Setälä, Mari Pekkanen-Mattila

Full text of article Electrophysiological evaluation of human induced pluripotent stem cell-derived cardiomyocytes obtained by different methods

Retrieval of the conductivity spectrum of tissues in vitro with novel multimodal tomography

M Lehti-Polojärvi, M J Räsänen, L E Viiri, H Vuorenpää, S Miettinen, A Seppänen and J Hyttinen

Full text of article Retrieval of the conductivity spectrum of tissues in vitro with novel multimodal tomography

Evaluation of the effect of donor weight on adipose stromal/stem cell characteristics by using weight-discordant monozygotic twin pairs

Miia Juntunen, Sini Heinonen, Heini Huhtala, Aila Rissanen, Jaakko Kaprio, Kirsi Kuismanen, Kirsi H. Pietiläinen, Susanna Miettinen & Mimmi Patrikoski

Full text of article Evaluation of the effect of donor weight on adipose stromal/stem cell characteristics by using weight-discordant monozygotic twin pairs

Chemical modification strategies for viscosity-dependent processing of gellan gum

Christine Gering, Anum Rasheed, Janne T. Koivisto, Jenny Párraga, Sampo Tuukkanen, Minna Kellomäki

Full text of article Chemical modification strategies for viscosity-dependent processing of gellan gum

Comprehensive characterisation of the compressive behaviour of hydrogels using a new modelling procedure and redefining compression testing

Jairan Nafar Dastgerdi, Janne T.Koivisto, Olli Orell, Pantea Rava, Jarno Jokinenen, Mikko Kanerva, Minna Kellomäki

Full text of article Comprehensive characterisation of the compressive behaviour of hydrogels using a new modelling procedure and redefining compression testing

Directional Growth of Human Neuronal Axons in a Microfluidic Device with Nanotopography on Azobenzene-Based Material

Mervi Ristola, Chiara Fedele, Sanna Hagman, Lassi Sukki, Fikret Emre Kapucu, Ropafadzo Mzezeva, Tanja Hyvärinen, Pasi Kallio, Arri Priimagi, Susanna Narkilahti.

Full text of article Directional Growth of Human Neuronal Axons in a Microfluidic Device with Nanotopography on Azobenzene-Based Material

Optical projection tomography as a quantitative tool for analysis of cell morphology and density in 3D hydrogels

Birhanu Belay, Janne T Koivisto, Jenny Parraga, Olli Koskela, Toni Montonen, Minna Kellomäki, Edite Figueiras, Jari Hyttinen.

Full text of article Optical projection tomography as a quantitative tool for analysis of cell morphology and density in 3D hydrogels

Paci Michelangelo, Penttinen Kirsi, Pekkanen-Mattila Mari, Koivumäki Jussi T.

Paci Michelangelo, Penttinen Kirsi, Pekkanen-Mattila Mari, Koivumäki Jussi T.

Full text of article Paci Michelangelo, Penttinen Kirsi, Pekkanen-Mattila Mari, Koivumäki Jussi T.

Photocross-linkable Methacrylated Polypeptides and Polysaccharides for Casting, Injecting, and 3D Fabrication.

Hatai Jongprasitkul, Sanna Turunen, Vijay Singh Parihar, Shambhavee Annurakshita, and Minna Kellomäki

Full text of article Photocross-linkable Methacrylated Polypeptides and Polysaccharides for Casting, Injecting, and 3D Fabrication.

Stem cell-based platform for modeling cardiac ischemia

Martta Häkli, Joose Kreutzer, Antti-Juhana Mäki, Hannu Välimäki, Henna Lappi, Heini Huhtala, Pasi Kallio, Katriina Aalto-Setälä & Mari Pekkanen-Mattila

Full text of article Stem cell-based platform for modeling cardiac ischemia

Electrophysiological evaluation of human induced pluripotent stem cell-derived cardiomyocytes obtained by different methods

Chandra Prajapati , Marisa Ojala, Henna Lappi, Katriina Aalto-Setälä, Mari Pekkanen-Mattila

Full text of article Electrophysiological evaluation of human induced pluripotent stem cell-derived cardiomyocytes obtained by different methods

Publications 2020

hiPSC-Derived Cardiomyocyte Model of LQT2 Syndrome Derived from Asymptomatic and Symptomatic Mutation Carriers Reproduces Clinical Differences in Aggregates but Not in Single Cells.

Shah D, Prajapati C, Penttinen K, Cherian RM, Koivumäki JT, Alexanova A, Hyttinen J, Aalto-Setälä K

Full text of article hiPSC-Derived Cardiomyocyte Model of LQT2 Syndrome Derived from Asymptomatic and Symptomatic Mutation Carriers Reproduces Clinical Differences in Aggregates but Not in Single Cells.

Covalent immobilization of luminescent oxygen indicators reduces cytotoxicity

Välimäki H, Hyvärinen T, Leivo J, Iftikhar H, Pekkanen-Mattila M, Rajan DK, Verho J, Kreutzer J, Ryynänen T, Pirhonen J, Aalto-Setälä K, Kallio P, Narkilahti S, Lekkala J.

Full text of article Covalent immobilization of luminescent oxygen indicators reduces cytotoxicity

Bioactive glass ions for in vitro osteogenesis and microvascularization in gellan gum-collagen hydrogels.

Vuornos K, Huhtala H, Kääriäinen M, Kuismanen K, Hupa L, Kellomäki M, Miettinen S

Full text of article Bioactive glass ions for in vitro osteogenesis and microvascularization in gellan gum-collagen hydrogels.

Pneumatic unidirectional cell stretching device for mechanobiological studies of cardiomyocytes.

Kreutzer J, Viehrig M, Pölönen RP, Zhao F, Ojala M, Aalto-Setälä K, Kallio P.

Full text of article Pneumatic unidirectional cell stretching device for mechanobiological studies of cardiomyocytes.

Transparent Microelectrode Arrays Fabricated by Ion Beam Assisted Deposition for Neuronal Cell in Vitro Recordings

Ryynänen T, Mzezewa R, Meriläinen E, Hyvärinen T, Lekkala J, Narkilahti S, Kallio P.

Full Text of article Transparent Microelectrode Arrays Fabricated by Ion Beam Assisted Deposition for Neuronal Cell in Vitro Recordings