Hyaluronic Acid-Based 3D Bioprinted Hydrogel Structure for Directed Axonal Guidance and Modeling Innervation In Vitro
Laura Honkamäki, Oskari Kulta, Paula Puistola, Karoliina Hopia, Promise Emeh, Lotta Isosaari, Anni Mörö, Susanna Narkilahti
Selected publications
Here you can find the most central CoEBoC publications. For the most extensive list, please refer to the webpages of the research groups.
Publications 2024
Barrier-free, open-top microfluidic chip for generating two distinct, interconnected 3D microvascular networks
Alma Yrjänäinen, Elina Mesiä, Ella Lampela, Joose Kreutzer, Jorma Vihinen, Kaisa Tornberg, Hanna Vuorenpää, Susanna Miettinen, Pasi Kallio & Antti-Juhana Mäki
Exploring Kainic Acid-Induced Alterations in Circular Tripartite Networks with Advanced Analysis Tools
Andrey Vinogradov, Emre Fikret Kapucu and Susanna Narkilahti
Human tripartite cortical network model for temporal assessment of alpha-synuclein aggregation and propagation in Parkinson’s Disease
Fikret Emre Kapucu, Iisa Tujula, Oskari Kulta, Lassi Sukki, Tomi Ryynänen, Hjalte Gram, Valtteri Vuolanto, Andrey Vinogradov, Joose Kreutzer, Poul Henning Jensen, Pasi Kallio & Susanna Narkilahti
Synthesis and Characterization of PolyHIPE-Gellan Gum Material with Tunable Macroporosity for Tissue Engineering Applications
Sweeta Akbari, Mart Kroon, Vijay Singh Parihar, Janne T. Koivisto, Markus Hannula, Minna Kellomäki, and Jari Hyttinen
In silico study of the mechanisms of hypoxia and contractile dysfunction during ischemia and reperfusion of hiPSC cardiomyocytes
Mohamadamin Forouzandehmehr ORCID logo , Michelangelo Paci ORCID logo , Jari Hyttinen ORCID logo , Jussi T. Koivumäki
Gellan gum-gelatin based cardiac models support formation of cellular networks and functional cardiomyocytes
Hanna Vuorenpää, Joona Valtonen, Kirsi Penttinen, Sanna Koskimäki, Emma Hovinen, Antti Ahola, Christine Gering, Jenny Parraga, Minna Kelloniemi, Jari Hyttinen, Minna Kellomäki, Katriina Aalto-Setälä, Susanna Miettinen & Mari Pekkanen-Mattila
Publications 2023
Ascorbic Acid 2-Phosphate-Releasing Supercritical Carbon Dioxide-Foamed Poly(L-Lactide-Co-epsilon-Caprolactone) Scaffolds Support Urothelial Cell Growth and Enhance Human Adipose-Derived Stromal Cell Proliferation and Collagen Production Journal of Tissue Engineering and Regenerative Medicine
Alma Kurki, Kaarlo Paakinaho, Markus Hannula, Jari Hyttinen, Susanna Miettinen, Reetta Sartoneva
Customized inkjet-printed 3D in vitro microelectrode arrays for 3D cell models
Tomi Ryynänen, H Peng, AM Moilanen, I Kopic, M Mäntysalo, Susanna Narkilahti, B Wolfrum, P Kallio
Oxygen gradient generator to improve in vitro modeling of ischemic stroke
EJ Santiago, J Kreutzer, E Bossink, P Kallio, J le Feber
In vitro α–synuclein aggregation and propagation model: A microphysiological model for the temporal assessment of neuronla functionality during the PFF-seeded α–synuclein aggregation and its propagation
Emre Kapucu, Iisa Tujula, Oskari Kulta, Lassi Sukki, Valtteri Vuolanto, Andrey Vinogradov, Pasi Kallio, Susanna Narkilahti
Simulation-Based Study of Control Strategies for Beating of Human Cardiomyocyte Cultures
Antti-Juhana Mäki, Jussi T Koivumäki, Jari Hyttinen, Pasi Kallio
Human tripartite cortical network model for temporal assessment of alpha-synuclein aggregation and propagation in Parkinson’s Disease
Fikret Emre Kapucu, Iisa Tujula, Oskari Kulta, Lassi Sukki, Tomi Ryynänen, Hjalte Gram, Valtteri Vuolanto, Andrey Vinogradov, Joose Kreutzer, Poul Henning Jensen, Pasi Kallio, Susanna Narkilahti
Toward Corneal Limbus In Vitro Model: Regulation of hPSC‐LSC Phenotype by Matrix Stiffness and Topography During Cell Differentiation Process
Maija Kauppila, Anni Mörö, Juan José Valle-Delgado, Teemu Ihalainen, Lassi Sukki, Paula Puistola, Pasi Kallio, Tanja Ilmarinen, Monika Österberg, Heli Skottman
Gut-on-chip devices as intestinal inflammation models and their future for studying multifactorial diseases.
Susanne Taavitsainen, Kati Juuti-Uusitalo, Kalle Kurppa, Katri Lindfors, Pasi Kallio, Minna Kellomäki
Improvements in Maturity and Stability of 3D iPSC-Derived Hepatocyte-like Cell Cultures.
Suominen, S, Hyypijev, T, Venäläinen, M, Yrjänäinen, A, Vuorenpää, H, Lehti-Polojärvi, M, Räsänen, M, Seppänen, M, Hyttinen, J, Miettinen, S, Aalto-Setälä, K, Viiri, L
Substrate microtopographies induce cellular alignment and affect nuclear force transduction
Birhanu Belay, Elina Mäntylä, Christian Maibohm, Oscar F. Silvestre, Jari Hyttinen, Jana B. Nieder, Teemu O. Ihalainen
Building blocks of microphysiological system to model physiology and pathophysiology of human heart
Hanna Vuorenpää, Miina Björninen, Hannu Välimäki, Antti Ahola, Mart Kroon, Laura Honkamäki, Jussi T. Koivumäki, Mari Pekkanen-Mattila
Simultaneous induction of vasculature and neuronal network formation on a chip reveals a dynamic interrelationship between cell types
Lotta Isosaari, Hanna Vuorenpää, Alma Yrjänäinen, Fikret Emre Kapucu, Minna Kelloniemi, Toni-Karri Pakarinen, Susanna Miettinen & Susanna Narkilahti
Heat Shock Protein 27 Is Involved in the Bioactive Glass Induced Osteogenic Response of Human Mesenchymal Stem Cells
Laura Hyväri, Sari Vanhatupa, Miina Ojansivu, Minna Kelloniemi, Toni-Karri Pakarinen, Leena Hupa and Susanna Miettinen
Immunomodulatory Functions of Adipose Mesenchymal Stromal/Stem Cell Derived from Donors With Type 2 Diabetes and Obesity on CD4 T Cells
Marwa Mahmoud, Miia Juntunen, Amna Adnan, Laura Kummola, Ilkka S Junttila, Minna Kelloniemi, Tuula Tyrväinen, Heini Huhtala, Abeer I Abd El Fattah, Khalda Amr, Alaa Mohamad El erian, Mimmi Patrikoski and Susanna Miettinen
Coronary artery disease patient‑derived iPSC‑hepatocytes have distinct miRNA profile that may alter lipid metabolism
Anna Alexanova , Emma Raitoharju , Joona Valtonen, Katriina Aalto‑Setälä & Leena E. Viiri
Publications 2022
Sequential Cross-linking of Gallic Acid-Functionalized GelMA-Based Bioinks with Enhanced Printability for Extrusion-Based 3D Bioprinting
Hatai Jongprasitkul, Sanna Turunen,, Vijay Singh Parihar, Minna Kellomäki
Bioactivated gellan gum hydrogels affect cellular rearrangement and cell response in vascular co-culture and subcutaneous implant models
Christine Gering, Jenny Párraga, Hanna Vuorenpää, Lucía Botero, Susanna Miettinen, Minna Kellomäki
Altered contractility in mutation-specific hypertrophic cardiomyopathy: A mechano-energetic in silico study with pharmacological insights
Mohamadamin Forouzandehmehr, Michelangelo Paci, Jussi Koivumäki and Jari Hyttinen
Characterization of self-healing hydrogels for biomedical applications
Jennika Karvinen, Minna Kellomäki
Growth Response and Differentiation of Bone Marrow-Derived Mesenchymal Stem/Stromal Cells in the Presence of Novel Multiple Myeloma Drug Melflufen
Arjen Gebraad, Roope Ohlsbom, Juho J Miettinen, Promise Emeh, Toni-Karri Pakarinen, Mikko Manninen, Antti Eskelinen 6, Kirsi Kuismanen, Ana Slipicevic, Fredrik Lehmann, Nina N Nupponen, Caroline A Heckman, Susanna Miettinen
Compartmentalized organ-on-a-chip structure for spatiotemporal control of oxygen microenvironments
Kaisa Tornberg , Hannu Välimäki, Silmu Valaskivi, Antti-Juhana Mäki, Matias Jokinen, Joose Kreutzer, Pasi Kallio
A method to measure data complexity of a complicated medical data set
Martti Juhola, Henry Joutsijoki, Kirsi Penttinen, Disheet Shah, Katriina Aalto-Setälä
Fluorescent hiPSC-derived MYH6-mScarlet cardiomyocytes for real-time tracking, imaging, and cardiotoxicity assays
Reeja Maria Cherian, Chandra Prajapati, Kirsi Penttinen, Martta Häkli, Janne T Koivisto, Mari Pekkanen-Mattila, Katriina Aalto-Setälä
Samanta S, Ylä-Outinen L, Rangasami V, Narkilahti S and Oommen OP.
Bidirectional cell-matrix interaction dictates neuronal network formation in a brain mimetic 3D scaffold.
Corrosion and Protection of Silicon Nitride Insulators in Microelectrode Array Applications.
Karttu A, Lahtonen K, Heikkilä J, Väliaho J, Narkilahti S, Lekkala J, Kallio P.
Establishment of a human induced pluripotent stem cell line (TAUi008-A) derived from a multiple sclerosis patient.
Lotila J, Hyvärinen T, Skottman H, Airas L, Narkilahti S, Hagman S.
Effect of cell culture media on extracellular vesicle secretion from mesenchymal stromal cells and neurons.
Karttunen J, Heiskanen M, Joki T, Hyysalo A, Navarro-Ferrandis V, Miettinen S, Narkilahti S, Asla Pitkänen
Practical guide for preparation, computational reconstruction and analysis of 3D human neuronal networks in control and ischaemic conditions.
Noora Räsänen, Venla Harju, Tiina Joki, Susanna Narkilahti
Comparative microelectrode array data of the functional development of hPSC-derived and rat neuronal networks
Fikret Emre Kapucu, Andrey Vinogradov, Tanja Hyvärinen, Laura Ylä-Outinen & Susanna Narkilahti
Human Neurons Form Axon-Mediated Functional Connections with Human Cardiomyocytes in Compartmentalized Microfluidic Chip
Martta Häkli,Satu Jäntti,Tiina Joki,Lassi Sukki,Kaisa Tornberg, Katriina Aalto-Setälä, Pasi Kallio, Mari Pekkanen-Mattila and Susanna Narkilahti
Cardiac Ischemia On-a-Chip: Antiarrhythmic Effect of Levosimendan on Ischemic Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Gaballah, M, Penttinen, K, Kreutzer, J, Mäki, AJ, Kallio, P, Aalto-Setälä, K
A kainic acid-induced seizure model in human pluripotent stem cell-derived cortical neurons for studying the role of IL-6 in the functional activity
Ropafadzo Mzezewa, Johanna Lotila, Heikki Kiiski, Andrey Vinogradov, Fikret Emre Kapucu, Jukka Peltola, Sanna Hagman, Susanna Narkilahti
Vasculogenic Potency of Bone Marrow- and Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells Results in Differing Vascular Network Phenotypes in a Microfluidic Chip
Anastasiia Mykuliak, Alma Yrjänäinen, Antti-Juhana Mäki, Gebraad, Lampela, Kääriäinen, Toni-Karri Pakarinen, Pasi Kallio, Susanna Miettinen, Hanna Vuorenpää
Self-assembled cellulose nanofiber–carbon nanotube nanocomposite films with anisotropic conductivity
Anne Skogberg, Sanna Siljander, Antti-Juhana Mäki, Mari Honkanen, Alexander Efimov, Markus Hannula, Panu Lahtinen, Sampo Tuukkanen, Tomas Björkqvist and Pasi Kallio
Microfabricated porous SU-8 membranes as innervation interfaces for hiPSC-neurons in microfluidic devices
T Salpavaara, T Joki, A Skogberg, M T Calejo, J Lekkala, S Narkilahti and P Kallio
Data analytics for cardiac diseases
Martti Juhola, Henry Joutsijoki, Kirsi Penttinen, Disheet Shah, Risto-Pekka Pölönen, Katriina Aalto-Setälä
Two-step crosslinking to enhance the printability of methacrylated gellan gum biomaterial ink for extrusion-based 3D bioprinting
Hatai Jongprasitkul, Sanna Turunen, Vijay Singh, Parihar, Minna Kellomäki
Publications 2021
Human induced pluripotent stem cell-based platform for modeling cardiac ischemia
Martta Häkli, Joose Kreutzer, Antti-Juhana Mäki, Hannu Välimäki, Henna Lappi, Heini Huhtala, Pasi Kallio, Katriina Aalto-Setälä & Mari Pekkanen-Mattila
Bidirectional cell-matrix interaction dictates neuronal network formation in a brain-mimetic 3D scaffold
Sumanta Samanta, Laura Ylä-Outinen, Vignesh Kumar, Rangasami, Susanna Narkilahti, Oommen P.Oommen
A mathematical model of hiPSC cardiomyocytes electromechanics
Mohamadamin Forouzandehmehr, Jussi T. Koivumäki, Jari Hyttinen, Michelangelo Paci
Astrocytes Exhibit a Protective Role in Neuronal Firing Patterns under Chemically Induced Seizures in Neuron–Astrocyte Co-Cultures
Annika Ahtiainen, Barbara Genocchi, Jarno M. A. Tanskanen, Michael T. Barros, Jari A. K. Hyttinen and Kerstin Lenk
Sensitivity of the Human Ventricular BPS2020 Action Potential Model to the In Silico Mechanisms of Ischemia
Mohamadamin Forouzandehmehr, Chiara Bartolucci, Jari Hyttinen, Jussi T Koivumäki, Michelangelo Paci
Multifrequency electrical impedance tomography in biological applications: A multimodal perspective
Mari Lehti-Polojärvi, Olli Koskela, Jari Hyttinen
Optical Projection Tomography for Particle Counting and Morphology Analysis
Olli Koskela, Md Tanvirul Kabir Chowdhury, Toni Montonen, Birhanu Belay, Sampsa Pursiainen, Jari Hyttinen
Analysis of Drug Effects on iPSC Cardiomyocytes with Machine Learning
Martti Juhola, Kirsi Penttinen, Henry Joutsijoki, Katriina Aalto-Setälä
On computational classification of genetic cardiac diseases applying iPSC cardiomyocytes
Martti Juhola, Henry Joutsijoki, Kirsi Penttinen, Disheet Shah, Katriina Aalto-Setälä
Electrophysiological evaluation of human induced pluripotent stem cell-derived cardiomyocytes obtained by different methods
Chandra Prajapati, Marisa Ojala, Henna Lappi, Katriina Aalto-Setälä, Mari Pekkanen-Mattila
Retrieval of the conductivity spectrum of tissues in vitro with novel multimodal tomography
M Lehti-Polojärvi, M J Räsänen, L E Viiri, H Vuorenpää, S Miettinen, A Seppänen and J Hyttinen
Evaluation of the effect of donor weight on adipose stromal/stem cell characteristics by using weight-discordant monozygotic twin pairs
Miia Juntunen, Sini Heinonen, Heini Huhtala, Aila Rissanen, Jaakko Kaprio, Kirsi Kuismanen, Kirsi H. Pietiläinen, Susanna Miettinen & Mimmi Patrikoski
Chemical modification strategies for viscosity-dependent processing of gellan gum
Christine Gering, Anum Rasheed, Janne T. Koivisto, Jenny Párraga, Sampo Tuukkanen, Minna Kellomäki
Comprehensive characterisation of the compressive behaviour of hydrogels using a new modelling procedure and redefining compression testing
Jairan Nafar Dastgerdi, Janne T.Koivisto, Olli Orell, Pantea Rava, Jarno Jokinenen, Mikko Kanerva, Minna Kellomäki
Directional Growth of Human Neuronal Axons in a Microfluidic Device with Nanotopography on Azobenzene-Based Material
Mervi Ristola, Chiara Fedele, Sanna Hagman, Lassi Sukki, Fikret Emre Kapucu, Ropafadzo Mzezeva, Tanja Hyvärinen, Pasi Kallio, Arri Priimagi, Susanna Narkilahti.
Optical projection tomography as a quantitative tool for analysis of cell morphology and density in 3D hydrogels
Birhanu Belay, Janne T Koivisto, Jenny Parraga, Olli Koskela, Toni Montonen, Minna Kellomäki, Edite Figueiras, Jari Hyttinen.
Paci Michelangelo, Penttinen Kirsi, Pekkanen-Mattila Mari, Koivumäki Jussi T.
Paci Michelangelo, Penttinen Kirsi, Pekkanen-Mattila Mari, Koivumäki Jussi T.
Photocross-linkable Methacrylated Polypeptides and Polysaccharides for Casting, Injecting, and 3D Fabrication.
Hatai Jongprasitkul, Sanna Turunen, Vijay Singh Parihar, Shambhavee Annurakshita, and Minna Kellomäki
Stem cell-based platform for modeling cardiac ischemia
Martta Häkli, Joose Kreutzer, Antti-Juhana Mäki, Hannu Välimäki, Henna Lappi, Heini Huhtala, Pasi Kallio, Katriina Aalto-Setälä & Mari Pekkanen-Mattila
Electrophysiological evaluation of human induced pluripotent stem cell-derived cardiomyocytes obtained by different methods
Chandra Prajapati , Marisa Ojala, Henna Lappi, Katriina Aalto-Setälä, Mari Pekkanen-Mattila
Publications 2020
hiPSC-Derived Cardiomyocyte Model of LQT2 Syndrome Derived from Asymptomatic and Symptomatic Mutation Carriers Reproduces Clinical Differences in Aggregates but Not in Single Cells.
Shah D, Prajapati C, Penttinen K, Cherian RM, Koivumäki JT, Alexanova A, Hyttinen J, Aalto-Setälä K
Covalent immobilization of luminescent oxygen indicators reduces cytotoxicity
Välimäki H, Hyvärinen T, Leivo J, Iftikhar H, Pekkanen-Mattila M, Rajan DK, Verho J, Kreutzer J, Ryynänen T, Pirhonen J, Aalto-Setälä K, Kallio P, Narkilahti S, Lekkala J.
Bioactive glass ions for in vitro osteogenesis and microvascularization in gellan gum-collagen hydrogels.
Vuornos K, Huhtala H, Kääriäinen M, Kuismanen K, Hupa L, Kellomäki M, Miettinen S
Pneumatic unidirectional cell stretching device for mechanobiological studies of cardiomyocytes.
Kreutzer J, Viehrig M, Pölönen RP, Zhao F, Ojala M, Aalto-Setälä K, Kallio P.
Transparent Microelectrode Arrays Fabricated by Ion Beam Assisted Deposition for Neuronal Cell in Vitro Recordings
Ryynänen T, Mzezewa R, Meriläinen E, Hyvärinen T, Lekkala J, Narkilahti S, Kallio P.