2019
- Jayaram, A, Wingate, A, Wetterskog, D, Conteduca, V, Khalaf, D, Sharabiani, MTA et al.. Plasma Androgen Receptor Copy Number Status at Emergence of Metastatic Castration-Resistant Prostate Cancer: A Pooled Multicohort Analysis. JCO Precis Oncol. 2019;3 :. doi: 10.1200/PO.19.00123. PubMed PMID:32923850 PubMed Central PMC7446348.
- Lindfors, K, Lin, J, Lee, HS, Hyöty, H, Nykter, M, Kurppa, K et al.. Metagenomics of the faecal virome indicate a cumulative effect of enterovirus and gluten amount on the risk of coeliac disease autoimmunity in genetically at risk children: the TEDDY study. Gut. 2020;69 (8):1416-1422. doi: 10.1136/gutjnl-2019-319809. PubMed PMID:31744911 PubMed Central PMC7234892.
- Ritch, E, Fu, SYF, Herberts, C, Wang, G, Warner, EW, Schönlau, E et al.. Identification of Hypermutation and Defective Mismatch Repair in ctDNA from Metastatic Prostate Cancer. Clin Cancer Res. 2020;26 (5):1114-1125. doi: 10.1158/1078-0432.CCR-19-1623. PubMed PMID:31744831 .
- Khalaf, DJ, Annala, M, Taavitsainen, S, Finch, DL, Oja, C, Vergidis, J et al.. Optimal sequencing of enzalutamide and abiraterone acetate plus prednisone in metastatic castration-resistant prostate cancer: a multicentre, randomised, open-label, phase 2, crossover trial. Lancet Oncol. 2019;20 (12):1730-1739. doi: 10.1016/S1470-2045(19)30688-6. PubMed PMID:31727538 .
- Granberg, KJ, Raita, A, Lehtinen, B, Tiihonen, AM, Kesseli, J, Annala, M et al.. Moderate-to-strong expression of FGFR3 and TP53 alterations in a subpopulation of choroid plexus tumors. Histol Histopathol. 2020;35 (7):673-680. doi: 10.14670/HH-18-180. PubMed PMID:31660579 .
- Harjula, SE, Saralahti, AK, Ojanen, MJT, Rantapero, T, Uusi-Mäkelä, MIE, Nykter, M et al.. Characterization of immune response against Mycobacterium marinum infection in the main hematopoietic organ of adult zebrafish (Danio rerio). Dev Comp Immunol. 2020;103 :103523. doi: 10.1016/j.dci.2019.103523. PubMed PMID:31626817 .
- Genitsch, V, Kollár, A, Vandekerkhove, G, Blarer, J, Furrer, M, Annala, M et al.. Morphologic and genomic characterization of urothelial to sarcomatoid transition in muscle-invasive bladder cancer. Urol Oncol. 2019;37 (11):826-836. doi: 10.1016/j.urolonc.2019.09.025. PubMed PMID:31585777 .
- Moradi, E, Marttinen, M, Häkkinen, T, Hiltunen, M, Nykter, M. Supervised pathway analysis of blood gene expression profiles in Alzheimer’s disease. Neurobiol Aging. 2019;84 :98-108. doi: 10.1016/j.neurobiolaging.2019.07.004. PubMed PMID:31522136 .
- Pölönen, P, Jawahar Deen, A, Leinonen, HM, Jyrkkänen, HK, Kuosmanen, S, Mononen, M et al.. Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma. Oncogene. 2019;38 (50):7473-7490. doi: 10.1038/s41388-019-0956-6. PubMed PMID:31444413 .
- Valkonen, M, Isola, J, Ylinen, O, Muhonen, V, Saxlin, A, Tolonen, T et al.. Cytokeratin-Supervised Deep Learning for Automatic Recognition of Epithelial Cells in Breast Cancers Stained for ER, PR, and Ki-67. IEEE Trans Med Imaging. 2020;39 (2):534-542. doi: 10.1109/TMI.2019.2933656. PubMed PMID:31398111 .
- Genitsch, V, Kollár, A, Vandekerkhove, G, Blarer, J, Furrer, M, Annala, M et al.. Morphologic and genomic characterization of urothelial to sarcomatoid transition in muscle-invasive bladder cancer. Urol Oncol. 2019;37 (9):573.e19-573.e29. doi: 10.1016/j.urolonc.2019.06.021. PubMed PMID:31358384 .
- Mehtonen, J, Pölönen, P, Häyrynen, S, Dufva, O, Lin, J, Liuksiala, T et al.. Data-driven characterization of molecular phenotypes across heterogeneous sample collections. Nucleic Acids Res. 2019;47 (13):e76. doi: 10.1093/nar/gkz281. PubMed PMID:31329928 PubMed Central PMC6648337.
- Taavitsainen, S, Annala, M, Ledet, E, Beja, K, Miller, PJ, Moses, M et al.. Evaluation of Commercial Circulating Tumor DNA Test in Metastatic Prostate Cancer. JCO Precis Oncol. 2019;3 :. doi: 10.1200/PO.19.00014. PubMed PMID:32914020 PubMed Central PMC7446428.
- Yang, J, Ylipää, A, Sun, Y, Zheng, H, Chen, K, Nykter, M et al.. Editor’s Note: Genomic and Molecular Characterization of Malignant Peripheral Nerve Sheath Tumor Identifies the IGF1R Pathway as a Primary Target for Treatment. Clin Cancer Res. 2019;25 (10):3195. doi: 10.1158/1078-0432.CCR-19-1144. PubMed PMID:31092619 .
- Hotte, SJ, Chi, KN, Joshua, AM, Tu, D, Macfarlane, RJ, Gregg, RW et al.. A Phase II Study of PX-866 in Patients With Recurrent or Metastatic Castration-resistant Prostate Cancer: Canadian Cancer Trials Group Study IND205. Clin Genitourin Cancer. 2019;17 (3):201-208.e1. doi: 10.1016/j.clgc.2019.03.005. PubMed PMID:31056399 .
- Pölönen, P, Mehtonen, J, Lin, J, Liuksiala, T, Häyrynen, S, Teppo, S et al.. Hemap: An Interactive Online Resource for Characterizing Molecular Phenotypes across Hematologic Malignancies. Cancer Res. 2019;79 (10):2466-2479. doi: 10.1158/0008-5472.CAN-18-2970. PubMed PMID:30940663 .
- Lehtipuro, S, Nykter, M, Granberg, KJ. Modes of immunosuppression in glioblastoma microenvironment. Oncotarget. 2019;10 (9):920-921. doi: 10.18632/oncotarget.26643. PubMed PMID:30847018 PubMed Central PMC6398170.
- Viiri, LE, Rantapero, T, Kiamehr, M, Alexanova, A, Oittinen, M, Viiri, K et al.. Extensive reprogramming of the nascent transcriptome during iPSC to hepatocyte differentiation. Sci Rep. 2019;9 (1):3562. doi: 10.1038/s41598-019-39215-0. PubMed PMID:30837492 PubMed Central PMC6401154.
- Sundahl, N, Vandekerkhove, G, Decaestecker, K, Meireson, A, De Visschere, P, Fonteyne, V et al.. Randomized Phase 1 Trial of Pembrolizumab with Sequential Versus Concomitant Stereotactic Body Radiotherapy in Metastatic Urothelial Carcinoma. Eur Urol. 2019;75 (5):707-711. doi: 10.1016/j.eururo.2019.01.009. PubMed PMID:30665814 .
- Vandekerkhove, G, Struss, WJ, Annala, M, Kallio, HML, Khalaf, D, Warner, EW et al.. Circulating Tumor DNA Abundance and Potential Utility in De Novo Metastatic Prostate Cancer. Eur Urol. 2019;75 (4):667-675. doi: 10.1016/j.eururo.2018.12.042. PubMed PMID:30638634 .
- Gubina, N, Naudi, A, Stefanatos, R, Jove, M, Scialo, F, Fernandez-Ayala, DJ et al.. Essential Physiological Differences Characterize Short- and Long-Lived Strains of Drosophila melanogaster. J Gerontol A Biol Sci Med Sci. 2019;74 (12):1835-1843. doi: 10.1093/gerona/gly143. PubMed PMID:29945183 .
Publications 2018
- Annala, M, Taavitsainen, S, Vandekerkhove, G, Bacon, JVW, Beja, K, Chi, KN et al.. Frequent mutation of the FOXA1 untranslated region in prostate cancer. Commun Biol. 2018;1 :122. doi: 10.1038/s42003-018-0128-1. PubMed PMID:30272002 PubMed Central PMC6123809.
- Latonen, L, Nykter, M, Visakorpi, T. Proteomics of prostate cancer – revealing how cancer cells master their messy genomes. Oncoscience. 2018;5 (7-8):216-217. doi: 10.18632/oncoscience.453. PubMed PMID:30234142 PubMed Central PMC6142899.
- Lin, J, Kimura, BY, Oikarinen, S, Nykter, M. Bioinformatics Assembling and Assessment of Novel Coxsackievirus B1 Genome. Methods Mol. Biol. 2018;1838 :261-272. doi: 10.1007/978-1-4939-8682-8_18. PubMed PMID:30129002 .
- Jylhä, A, Nättinen, J, Aapola, U, Mikhailova, A, Nykter, M, Zhou, L et al.. Comparison of iTRAQ and SWATH in a clinical study with multiple time points. Clin Proteomics. 2018;15 :24. doi: 10.1186/s12014-018-9201-5. PubMed PMID:30069167 PubMed Central PMC6065059.
- Veskimäe, K, Scaravilli, M, Niininen, W, Karvonen, H, Jaatinen, S, Nykter, M et al.. Expression Analysis of Platinum Sensitive and Resistant Epithelial Ovarian Cancer Patient Samples Reveals New Candidates for Targeted Therapies. Transl Oncol. 2018;11 (5):1160-1170. doi: 10.1016/j.tranon.2018.07.010. PubMed PMID:30056367 PubMed Central PMC6079561.
- Chedgy, EC, Vandekerkhove, G, Herberts, C, Annala, M, Donoghue, AJ, Sigouros, M et al.. Biallelic tumour suppressor loss and DNA repair defects in de novo small-cell prostate carcinoma. J. Pathol. 2018;246 (2):244-253. doi: 10.1002/path.5137. PubMed PMID:30015382 .
- Kallio, HML, Hieta, R, Latonen, L, Brofeldt, A, Annala, M, Kivinummi, K et al.. Constitutively active androgen receptor splice variants AR-V3, AR-V7 and AR-V9 are co-expressed in castration-resistant prostate cancer metastases. Br. J. Cancer. 2018;119 (3):347-356. doi: 10.1038/s41416-018-0172-0. PubMed PMID:29988112 .
- Harjula, SE, Ojanen, MJT, Taavitsainen, S, Nykter, M, Rämet, M. Interleukin 10 mutant zebrafish have an enhanced interferon gamma response and improved survival against a Mycobacterium marinum infection. Sci Rep. 2018;8 (1):10360. doi: 10.1038/s41598-018-28511-w. PubMed PMID:29985419 PubMed Central PMC6037744.
- Gubina, N, Naudi, A, Stefanatos, R, Jove, M, Scialo, F, Fernandez-Ayala, DJ et al.. Essential physiological differences characterise short- and long-lived strains of Drosophila melanogaster. J. Gerontol. A Biol. Sci. Med. Sci. 2018; :. doi: 10.1093/gerona/gly143. PubMed PMID:29945183 .
- Luoto, S, Hermelo, I, Vuorinen, EM, Hannus, P, Kesseli, J, Nykter, M et al.. Computational Characterization of Suppressive Immune Microenvironments in Glioblastoma. Cancer Res. 2018;78 (19):5574-5585. doi: 10.1158/0008-5472.CAN-17-3714. PubMed PMID:29921698 .
- Nordfors, K, Haapasalo, J, Afyounian, E, Tuominen, J, Annala, M, Häyrynen, S et al.. Erratum: Whole-exome sequencing identifies germline mutation in TP53 and ATRX in a child with genomically aberrant AT/RT and her mother with anaplastic astrocytoma. Cold Spring Harb Mol Case Stud. 2018;4 (3):. doi: 10.1101/mcs.a003129. PubMed PMID:29858379 PubMed Central PMC5983177.
- Park, ES, Yan, JP, Ang, RA, Lee, JH, Deng, X, Duffy, SP et al.. Isolation and genome sequencing of individual circulating tumor cells using hydrogel encapsulation and laser capture microdissection. Lab Chip. 2018;18 (12):1736-1749. doi: 10.1039/c8lc00184g. PubMed PMID:29762619 .
- Kartasalo, K, Latonen, L, Vihinen, J, Visakorpi, T, Nykter, M, Ruusuvuori, P et al.. Comparative analysis of tissue reconstruction algorithms for 3D histology. Bioinformatics. 2018;34 (17):3013-3021. doi: 10.1093/bioinformatics/bty210. PubMed PMID:29684099 PubMed Central PMC6129300.
- Uusi-Mäkelä, MIE, Barker, HR, Bäuerlein, CA, Häkkinen, T, Nykter, M, Rämet, M et al.. Chromatin accessibility is associated with CRISPR-Cas9 efficiency in the zebrafish (Danio rerio). PLoS ONE. 2018;13 (4):e0196238. doi: 10.1371/journal.pone.0196238. PubMed PMID:29684067 PubMed Central PMC5912780.
- Gao, Q, Liang, WW, Foltz, SM, Mutharasu, G, Jayasinghe, RG, Cao, S et al.. Driver Fusions and Their Implications in the Development and Treatment of Human Cancers. Cell Rep. 2018;23 (1):227-238.e3. doi: 10.1016/j.celrep.2018.03.050. PubMed PMID:29617662 PubMed Central PMC5916809.
- Nordfors, K, Haapasalo, J, Afyounian, E, Tuominen, J, Annala, M, Häyrynen, S et al.. Whole-exome sequencing identifies germline mutation in TP53 and ATRX in a child with genomically aberrant AT/RT and her mother with anaplastic astrocytoma. Cold Spring Harb Mol Case Stud. 2018;4 (2):. doi: 10.1101/mcs.a002246. PubMed PMID:29602769 PubMed Central PMC5880256.
- Latonen, L, Afyounian, E, Jylhä, A, Nättinen, J, Aapola, U, Annala, M et al.. Integrative proteomics in prostate cancer uncovers robustness against genomic and transcriptomic aberrations during disease progression. Nat Commun. 2018;9 (1):1176. doi: 10.1038/s41467-018-03573-6. PubMed PMID:29563510 PubMed Central PMC5862881.
- Haapasalo, J, Nordfors, K, Granberg, KJ, Kivioja, T, Nykter, M, Haapasalo, H et al.. NRF2, DJ1 and SNRX1 and their prognostic impact in astrocytic gliomas. Histol. Histopathol. 2018;33 (8):791-801. doi: 10.14670/HH-11-973. PubMed PMID:29441509 .
- Annala, M, Vandekerkhove, G, Khalaf, D, Taavitsainen, S, Beja, K, Warner, EW et al.. Circulating Tumor DNA Genomics Correlate with Resistance to Abiraterone and Enzalutamide in Prostate Cancer. Cancer Discov. 2018;8 (4):444-457. doi: 10.1158/2159-8290.CD-17-0937. PubMed PMID:29367197 .
- Högnäs, G, Kivinummi, K, Kallio, HML, Hieta, R, Ruusuvuori, P, Koskenalho, A et al.. Feasibility of Prostate PAXgene Fixation for Molecular Research and Diagnostic Surgical Pathology: Comparison of Matched Fresh Frozen, FFPE, and PFPE Tissues. Am. J. Surg. Pathol. 2018;42 (1):103-115. doi: 10.1097/PAS.0000000000000961. PubMed PMID:28984675 .
- Nättinen, J, Jylhä, A, Aapola, U, Enríquez-de-Salamanca, A, Pinto-Fraga, J, López-Miguel, A et al.. Topical fluorometholone treatment and desiccating stress change inflammatory protein expression in tears. Ocul Surf. 2018;16 (1):84-92. doi: 10.1016/j.jtos.2017.09.003. PubMed PMID:28918083 .
Publications 2017
- Karvonen, H, Chiron, D, Niininen, W, Ek, S, Jerkeman, M, Moradi, E et al.. Crosstalk between ROR1 and BCR pathways defines novel treatment strategies in mantle cell lymphoma. Blood Adv. 2017;1 (24):2257-2268. doi: 10.1182/bloodadvances.2017010215. PubMed PMID:29296874 PubMed Central PMC5737127.
- Kivinummi, K, Urbanucci, A, Leinonen, K, Tammela, TLJ, Annala, M, Isaacs, WB et al.. The expression of AURKA is androgen regulated in castration-resistant prostate cancer. Sci Rep. 2017;7 (1):17978. doi: 10.1038/s41598-017-18210-3. PubMed PMID:29269934 PubMed Central PMC5740165.
- Wyatt, AW, Annala, M, Aggarwal, R, Beja, K, Feng, F, Youngren, J et al.. Concordance of Circulating Tumor DNA and Matched Metastatic Tissue Biopsy in Prostate Cancer. J. Natl. Cancer Inst. 2017;109 (12):. doi: 10.1093/jnci/djx118. PubMed PMID:29206995 .
- Hyysalo, A, Ristola, M, Mäkinen, ME, Häyrynen, S, Nykter, M, Narkilahti, S et al.. Laminin α5 substrates promote survival, network formation and functional development of human pluripotent stem cell-derived neurons in vitro. Stem Cell Res. 2017;24 :118-127. doi: 10.1016/j.scr.2017.09.002. PubMed PMID:28926760 .
- Nättinen, J, Jylhä, A, Aapola, U, Enríquez-de-Salamanca, A, Pinto-Fraga, J, López-Miguel, A et al.. Topical fluorometholone treatment and desiccating stress change inflammatory protein expression in tears. Ocul Surf. 2018;16 (1):84-92. doi: 10.1016/j.jtos.2017.09.003. PubMed PMID:28918083 .
- Beltran, H, Wyatt, AW, Chedgy, EC, Donoghue, A, Annala, M, Warner, EW et al.. Impact of Therapy on Genomics and Transcriptomics in High-Risk Prostate Cancer Treated with Neoadjuvant Docetaxel and Androgen Deprivation Therapy. Clin. Cancer Res. 2017;23 (22):6802-6811. doi: 10.1158/1078-0432.CCR-17-1034. PubMed PMID:28842510 PubMed Central PMC5690882.
- Kytola, V, Topaloglu, U, Miller, LD, Bitting, RL, Goodman, MM, D Agostino, RB Jr et al.. Mutational Landscapes of Smoking-Related Cancers in Caucasians and African Americans: Precision Oncology Perspectives at Wake Forest Baptist Comprehensive Cancer Center. Theranostics. 2017;7 (11):2914-2923. doi: 10.7150/thno.20355. PubMed PMID:28824725 PubMed Central PMC5562225.
- Vandekerkhove, G, Todenhöfer, T, Annala, M, Struss, WJ, Wong, A, Beja, K et al.. Circulating Tumor DNA Reveals Clinically Actionable Somatic Genome of Metastatic Bladder Cancer. Clin. Cancer Res. 2017;23 (21):6487-6497. doi: 10.1158/1078-0432.CCR-17-1140. PubMed PMID:28760909 .
- Zhang, K, Myllymäki, SM, Gao, P, Devarajan, R, Kytölä, V, Nykter, M et al.. Oncogenic K-Ras upregulates ITGA6 expression via FOSL1 to induce anoikis resistance and synergizes with αV-Class integrins to promote EMT. Oncogene. 2017;36 (41):5681-5694. doi: 10.1038/onc.2017.177. PubMed PMID:28604746 PubMed Central PMC5658677.
- Urbanucci, A, Barfeld, SJ, Kytölä, V, Itkonen, HM, Coleman, IM, Vodák, D et al.. Androgen Receptor Deregulation Drives Bromodomain-Mediated Chromatin Alterations in Prostate Cancer. Cell Rep. 2017;19 (10):2045-2059. doi: 10.1016/j.celrep.2017.05.049. PubMed PMID:28591577 PubMed Central PMC5675034.
- Lin, J, Kramna, L, Autio, R, Hyöty, H, Nykter, M, Cinek, O et al.. Vipie: web pipeline for parallel characterization of viral populations from multiple NGS samples. BMC Genomics. 2017;18 (1):378. doi: 10.1186/s12864-017-3721-7. PubMed PMID:28506246 PubMed Central PMC5430618.
- Tarkkonen, K, Hieta, R, Kytölä, V, Nykter, M, Kiviranta, R. Comparative analysis of osteoblast gene expression profiles and Runx2 genomic occupancy of mouse and human osteoblasts in vitro. Gene. 2017;626 :119-131. doi: 10.1016/j.gene.2017.05.028. PubMed PMID:28502869 .
- Lund, RJ, Rahkonen, N, Malonzo, M, Kauko, L, Emani, MR, Kivinen, V et al.. RNA Polymerase III Subunit POLR3G Regulates Specific Subsets of PolyA+ and SmallRNA Transcriptomes and Splicing in Human Pluripotent Stem Cells. Stem Cell Reports. 2017;8 (5):1442-1454. doi: 10.1016/j.stemcr.2017.04.016. PubMed PMID:28494942 PubMed Central PMC5425787.
- Yang, M, Topaloglu, U, Petty, WJ, Pagni, M, Foley, KL, Grant, SC et al.. Circulating mutational portrait of cancer: manifestation of aggressive clonal events in both early and late stages. J Hematol Oncol. 2017;10 (1):100. doi: 10.1186/s13045-017-0468-1. PubMed PMID:28472989 PubMed Central PMC5418716.
- Lehtinen, B, Raita, A, Kesseli, J, Annala, M, Nordfors, K, Yli-Harja, O et al.. Clinical association analysis of ependymomas and pilocytic astrocytomas reveals elevated FGFR3 and FGFR1 expression in aggressive ependymomas. BMC Cancer. 2017;17 (1):310. doi: 10.1186/s12885-017-3274-9. PubMed PMID:28468611 PubMed Central PMC5415775.
- Quigley, D, Alumkal, JJ, Wyatt, AW, Kothari, V, Foye, A, Lloyd, P et al.. Analysis of Circulating Cell-Free DNA Identifies Multiclonal Heterogeneity of BRCA2 Reversion Mutations Associated with Resistance to PARP Inhibitors. Cancer Discov. 2017;7 (9):999-1005. doi: 10.1158/2159-8290.CD-17-0146. PubMed PMID:28450426 PubMed Central PMC5581695.
- Valkonen, M, Kartasalo, K, Liimatainen, K, Nykter, M, Latonen, L, Ruusuvuori, P et al.. Metastasis detection from whole slide images using local features and random forests. Cytometry A. 2017;91 (6):555-565. doi: 10.1002/cyto.a.23089. PubMed PMID:28426134 .
- Afyounian, E, Annala, M, Nykter, M. Segmentum: a tool for copy number analysis of cancer genomes. BMC Bioinformatics. 2017;18 (1):215. doi: 10.1186/s12859-017-1626-8. PubMed PMID:28407731 PubMed Central PMC5390478.
- Granberg, KJ, Annala, M, Lehtinen, B, Kesseli, J, Haapasalo, J, Ruusuvuori, P et al.. Strong FGFR3 staining is a marker for FGFR3 fusions in diffuse gliomas. Neuro-oncology. 2017;19 (9):1206-1216. doi: 10.1093/neuonc/nox028. PubMed PMID:28379477 PubMed Central PMC5570261.
- Valkonen, M, Ruusuvuori, P, Kartasalo, K, Nykter, M, Visakorpi, T, Latonen, L et al.. Analysis of spatial heterogeneity in normal epithelium and preneoplastic alterations in mouse prostate tumor models. Sci Rep. 2017;7 :44831. doi: 10.1038/srep44831. PubMed PMID:28317907 PubMed Central PMC5357939.
- Annala, M, Struss, WJ, Warner, EW, Beja, K, Vandekerkhove, G, Wong, A et al.. Treatment Outcomes and Tumor Loss of Heterozygosity in Germline DNA Repair-deficient Prostate Cancer. Eur. Urol. 2017;72 (1):34-42. doi: 10.1016/j.eururo.2017.02.023. PubMed PMID:28259476 .
- Ampuja, M, Rantapero, T, Rodriguez-Martinez, A, Palmroth, M, Alarmo, EL, Nykter, M et al.. Integrated RNA-seq and DNase-seq analyses identify phenotype-specific BMP4 signaling in breast cancer. BMC Genomics. 2017;18 (1):68. doi: 10.1186/s12864-016-3428-1. PubMed PMID:28077088 PubMed Central PMC5225521.
- Grönroos, T, Teppo, S, Mehtonen, J, Laukkanen, S, Liuksiala, T, Nykter, M et al.. Overexpression of PTP4A3 in ETV6-RUNX1 acute lymphoblastic leukemia. Leuk. Res. 2017;54 :1-6. doi: 10.1016/j.leukres.2016.12.005. PubMed PMID:28063378 .
- Annala, M, Nappi, L, Azad, AA, Mo, F, Fazli, L, Chi, KN et al.. Molecular Dissection of Complete Response to Receptor Tyrosine Kinase Inhibition in Type II Papillary Renal Cell Carcinoma. Clin Genitourin Cancer. 2017;15 (1):e145-e150. doi: 10.1016/j.clgc.2016.05.019. PubMed PMID:27324055 .
Publications 2016
- Grönroos, T, Teppo, S, Mehtonen, J, Laukkanen, S, Liuksiala, T, Nykter, M et al.. Overexpression of PTP4A3 in ETV6-RUNX1 acute lymphoblastic leukemia. Leuk. Res. 2017;54 :1-6. doi: 10.1016/j.leukres.2016.12.005. PubMed PMID:28063378 .
- Ulman, V, Svoboda, D, Nykter, M, Kozubek, M, Ruusuvuori, P. Virtual cell imaging: A review on simulation methods employed in image cytometry. Cytometry A. 2016;89 (12):1057-1072. doi: 10.1002/cyto.a.23031. PubMed PMID:27922735 .
- Teppo, S, Laukkanen, S, Liuksiala, T, Nordlund, J, Oittinen, M, Teittinen, K et al.. Genome-wide repression of eRNA and target gene loci by the ETV6-RUNX1 fusion in acute leukemia. Genome Res. 2016;26 (11):1468-1477. doi: 10.1101/gr.193649.115. PubMed PMID:27620872 PubMed Central PMC5088590.
- Määttä, K, Rantapero, T, Lindström, A, Nykter, M, Kankuri-Tammilehto, M, Laasanen, SL et al.. Whole-exome sequencing of Finnish hereditary breast cancer families. Eur. J. Hum. Genet. 2016;25 (1):85-93. doi: 10.1038/ejhg.2016.141. PubMed PMID:27782108 PubMed Central PMC5159774.
- Veskimäe, K, Staff, S, Grönholm, A, Pesu, M, Laaksonen, M, Nykter, M et al.. Assessment of PARP protein expression in epithelial ovarian cancer by ELISA pharmacodynamic assay and immunohistochemistry. Tumour Biol. 2016;37 (9):11991-11999. doi: 10.1007/s13277-016-5062-6. PubMed PMID:27155850 .
- Cordova, ZM, Grönholm, A, Kytölä, V, Taverniti, V, Hämäläinen, S, Aittomäki, S et al.. Myeloid cell expressed proprotein convertase FURIN attenuates inflammation. Oncotarget. 2016;7 (34):54392-54404. doi: 10.18632/oncotarget.11106. PubMed PMID:27527873 PubMed Central PMC5342350.
- Annala, M, Nappi, L, Azad, AA, Mo, F, Fazli, L, Chi, KN et al.. Molecular Dissection of Complete Response to Receptor Tyrosine Kinase Inhibition in Type II Papillary Renal Cell Carcinoma. Clin Genitourin Cancer. 2017;15 (1):e145-e150. doi: 10.1016/j.clgc.2016.05.019. PubMed PMID:27324055 .
- Wyatt, AW, Azad, AA, Volik, SV, Annala, M, Beja, K, McConeghy, B et al.. Genomic Alterations in Cell-Free DNA and Enzalutamide Resistance in Castration-Resistant Prostate Cancer. JAMA Oncol. 2016;2 (12):1598-1606. doi: 10.1001/jamaoncol.2016.0494. PubMed PMID:27148695 PubMed Central PMC5097690.
- Bova, GS, Kallio, HM, Annala, M, Kivinummi, K, Högnäs, G, Häyrynen, S et al.. Integrated clinical, whole-genome, and transcriptome analysis of multisampled lethal metastatic prostate cancer. Cold Spring Harb Mol Case Stud. 2016;2 (3):a000752. doi: 10.1101/mcs.a000752. PubMed PMID:27148588 PubMed Central PMC4853517.
- Nurminen, R, Rantapero, T, Wong, SC, Fischer, D, Lehtonen, R, Tammela, TL et al.. Expressional profiling of prostate cancer risk SNPs at 11q13.5 identifies DGAT2 as a new target gene. Genes Chromosomes Cancer. 2016;55 (8):661-73. doi: 10.1002/gcc.22368. PubMed PMID:27113481 .
- Ruusuvuori, P, Valkonen, M, Nykter, M, Visakorpi, T, Latonen, L. Feature-based analysis of mouse prostatic intraepithelial neoplasia in histological tissue sections. J Pathol Inform. 2016;7 :5. doi: 10.4103/2153-3539.175378. PubMed PMID:26955503 PubMed Central PMC4763506.
- Sjöblom, L, Saramäki, O, Annala, M, Leinonen, K, Nättinen, J, Tolonen, T et al.. Microseminoprotein-Beta Expression in Different Stages of Prostate Cancer. PLoS ONE. 2016;11 (3):e0150241. doi: 10.1371/journal.pone.0150241. PubMed PMID:26939004 PubMed Central PMC4777373.
- Chedgy, EC, Annala, M, Beja, K, Warner, EW, Gleave, ME, Chi, KN et al.. Moving Toward Personalized Care: Liquid Biopsy Predicts Response to Cisplatin in an Unusual Case of BRCA2-Null Neuroendocrine Prostate Cancer. Clin Genitourin Cancer. 2016;14 (2):e233-6. doi: 10.1016/j.clgc.2015.12.023. PubMed PMID:26797585 .
- Alarmo, EL, Havunen, R, Häyrynen, S, Penkki, S, Ketolainen, J, Nykter, M et al.. Bone morphogenetic protein 4 regulates microRNA expression in breast cancer cell lines in diverse fashion. Genes Chromosomes Cancer. 2016;55 (3):227-36. doi: 10.1002/gcc.22324. PubMed PMID:26684238 .
- Chua, CY, Liu, Y, Granberg, KJ, Hu, L, Haapasalo, H, Annala, MJ et al.. IGFBP2 potentiates nuclear EGFR-STAT3 signaling. Oncogene. 2016;35 (6):738-47. doi: 10.1038/onc.2015.131. PubMed PMID:25893308 PubMed Central PMC4615268.
Publications 2015
- Chedgy, EC, Annala, M, Beja, K, Warner, EW, Gleave, ME, Chi, KN et al.. Moving Toward Personalized Care: Liquid Biopsy Predicts Response to Cisplatin in an Unusual Case of BRCA2-Null Neuroendocrine Prostate Cancer. Clin Genitourin Cancer. 2016;14 (2):e233-6. doi: 10.1016/j.clgc.2015.12.023. PubMed PMID:26797585 .
- Alarmo, EL, Havunen, R, Häyrynen, S, Penkki, S, Ketolainen, J, Nykter, M et al.. Bone morphogenetic protein 4 regulates microRNA expression in breast cancer cell lines in diverse fashion. Genes Chromosomes Cancer. 2016;55 (3):227-36. doi: 10.1002/gcc.22324. PubMed PMID:26684238 .
- Cancer Genome Atlas Research Network. The Molecular Taxonomy of Primary Prostate Cancer. Cell. 2015;163 (4):1011-25. doi: 10.1016/j.cell.2015.10.025. PubMed PMID:26544944 PubMed Central PMC4695400.
- Ylipää, A, Kivinummi, K, Kohvakka, A, Annala, M, Latonen, L, Scaravilli, M et al.. Transcriptome Sequencing Reveals PCAT5 as a Novel ERG-Regulated Long Noncoding RNA in Prostate Cancer. Cancer Res. 2015;75 (19):4026-31. doi: 10.1158/0008-5472.CAN-15-0217. PubMed PMID:26282172 .
- Rane, JK, Ylipää, A, Adamson, R, Mann, VM, Simms, MS, Collins, AT et al.. Construction of therapeutically relevant human prostate epithelial fate map by utilising miRNA and mRNA microarray expression data. Br. J. Cancer. 2015;113 (4):611-5. doi: 10.1038/bjc.2015.262. PubMed PMID:26203762 PubMed Central PMC4647689.
- Nordfors, K, Haapasalo, J, Mäkelä, K, Granberg, KJ, Nykter, M, Korja, M et al.. Twist predicts poor outcome of patients with astrocytic glioma. J. Clin. Pathol. 2015;68 (11):905-12. doi: 10.1136/jclinpath-2015-202868. PubMed PMID:26163539 .
- Kaukoniemi, KM, Rauhala, HE, Scaravilli, M, Latonen, L, Annala, M, Vessella, RL et al.. Epigenetically altered miR-193b targets cyclin D1 in prostate cancer. Cancer Med. 2015;4 (9):1417-25. doi: 10.1002/cam4.486. PubMed PMID:26129688 PubMed Central PMC4567026.
- Chua, CY, Liu, Y, Granberg, KJ, Hu, L, Haapasalo, H, Annala, MJ et al.. IGFBP2 potentiates nuclear EGFR-STAT3 signaling. Oncogene. 2016;35 (6):738-47. doi: 10.1038/onc.2015.131. PubMed PMID:25893308 PubMed Central PMC4615268.
- Marttila, S, Kananen, L, Häyrynen, S, Jylhävä, J, Nevalainen, T, Hervonen, A et al.. Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression. BMC Genomics. 2015;16 :179. doi: 10.1186/s12864-015-1381-z. PubMed PMID:25888029 PubMed Central PMC4404609.
- Gundem, G, Van Loo, P, Kremeyer, B, Alexandrov, LB, Tubio, JMC, Papaemmanuil, E et al.. The evolutionary history of lethal metastatic prostate cancer. Nature. 2015;520 (7547):353-357. doi: 10.1038/nature14347. PubMed PMID:25830880 PubMed Central PMC4413032.
- Annala, M, Kivinummi, K, Tuominen, J, Karakurt, S, Granberg, K, Latonen, L et al.. Recurrent SKIL-activating rearrangements in ETS-negative prostate cancer. Oncotarget. 2015;6 (8):6235-50. doi: 10.18632/oncotarget.3359. PubMed PMID:25749039 PubMed Central PMC4467434.
- Turner, KM, Sun, Y, Ji, P, Granberg, KJ, Bernard, B, Hu, L et al.. Genomically amplified Akt3 activates DNA repair pathway and promotes glioma progression. Proc. Natl. Acad. Sci. U.S.A. 2015;112 (11):3421-6. doi: 10.1073/pnas.1414573112. PubMed PMID:25737557 PubMed Central PMC4371922.
- Scaravilli, M, Porkka, KP, Brofeldt, A, Annala, M, Tammela, TL, Jenster, GW et al.. MiR-1247-5p is overexpressed in castration resistant prostate cancer and targets MYCBP2. Prostate. 2015;75 (8):798-805. doi: 10.1002/pros.22961. PubMed PMID:25731699 .
- Veskimäe, K, Staff, S, Tabaro, F, Nykter, M, Isola, J, Mäenpää, J et al.. Microarray analysis of differentially expressed genes in ovarian and fallopian tube epithelium from risk-reducing salpingo-oophorectomies. Genes Chromosomes Cancer. 2015;54 (5):276-87. doi: 10.1002/gcc.22241. PubMed PMID:25706666 .
- Rane, JK, Scaravilli, M, Ylipää, A, Pellacani, D, Mann, VM, Simms, MS et al.. MicroRNA expression profile of primary prostate cancer stem cells as a source of biomarkers and therapeutic targets. Eur. Urol. 2015;67 (1):7-10. doi: 10.1016/j.eururo.2014.09.005. PubMed PMID:25234358 .
- Li, X, Liu, Y, Granberg, KJ, Wang, Q, Moore, LM, Ji, P et al.. Two mature products of MIR-491 coordinate to suppress key cancer hallmarks in glioblastoma. Oncogene. 2015;34 (13):1619-1628. doi: 10.1038/onc.2014.98. PubMed PMID:24747968 PubMed Central PMC4205227.
Publications 2014
- Yang, J, Annala, M, Ji, P, Wang, G, Zheng, H, Codgell, D et al.. Recurrent LRP1-SNRNP25 and KCNMB4-CCND3 fusion genes promote tumor cell motility in human osteosarcoma. J Hematol Oncol. 2014;7 :76. doi: 10.1186/s13045-014-0076-2. PubMed PMID:25300797 PubMed Central PMC4197299.
- Rane, JK, Scaravilli, M, Ylipää, A, Pellacani, D, Mann, VM, Simms, MS et al.. MicroRNA expression profile of primary prostate cancer stem cells as a source of biomarkers and therapeutic targets. Eur. Urol. 2015;67 (1):7-10. doi: 10.1016/j.eururo.2014.09.005. PubMed PMID:25234358 .
- Annala, M, Kivinummi, K, Leinonen, K, Tuominen, J, Zhang, W, Visakorpi, T et al.. DOT1L-HES6 fusion drives androgen independent growth in prostate cancer. EMBO Mol Med. 2014;6 (9):1121-3. doi: 10.15252/emmm.201404210. PubMed PMID:25006183 PubMed Central PMC4197859.
- Li, X, Liu, Y, Granberg, KJ, Wang, Q, Moore, LM, Ji, P et al.. Two mature products of MIR-491 coordinate to suppress key cancer hallmarks in glioblastoma. Oncogene. 2015;34 (13):1619-1628. doi: 10.1038/onc.2014.98. PubMed PMID:24747968 PubMed Central PMC4205227.
- Parker, BC, Engels, M, Annala, M, Zhang, W. Emergence of FGFR family gene fusions as therapeutic targets in a wide spectrum of solid tumours. J. Pathol. 2014;232 (1):4-15. . PubMed PMID:24588013 .
- Ruusuvuori, P, Lin, J, Scott, AC, Tan, Z, Sorsa, S, Kallio, A et al.. Quantitative analysis of colony morphology in yeast. BioTechniques. 2014;56 (1):18-27. doi: 10.2144/000114123. PubMed PMID:24447135 PubMed Central PMC3996921.
- Huang, Q, Whitington, T, Gao, P, Lindberg, JF, Yang, Y, Sun, J et al.. A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding. Nat. Genet. 2014;46 (2):126-35. doi: 10.1038/ng.2862. PubMed PMID:24390282 .
- Annala, M, Mykrä, H, Tolkkinen, M, Kauppila, T, Muotka, T. Are biological communities in naturally unproductive streams resistant to additional anthropogenic stressors?. Ecol Appl. ;24 (8):1887-97. . PubMed PMID:29185660 .
- Liuksiala, T, Teittinen, KJ, Granberg, K, Heinäniemi, M, Annala, M, Mäki, M et al.. Overexpression of SNORD114-3 marks acute promyelocytic leukemia. Leukemia. 2014;28 (1):233-6. doi: 10.1038/leu.2013.250. PubMed PMID:23979522 .
Publications 2013
- Lin, J, Kreisberg, R, Kallio, A, Dudley, AM, Nykter, M, Shmulevich, I et al.. POMO–Plotting Omics analysis results for Multiple Organisms. BMC Genomics. 2013;14 :918. doi: 10.1186/1471-2164-14-918. PubMed PMID:24365393 PubMed Central PMC3880012.
- Ylipää, A, Yli-Harja, O, Zhang, W, Nykter, M. Characterization of aberrant pathways across human cancers. BMC Syst Biol. 2013;7 Suppl 1 :S1. doi: 10.1186/1752-0509-7-S1-S1. PubMed PMID:24267866 PubMed Central PMC3750561.
- Turpeinen, H, Oksanen, A, Kivinen, V, Kukkurainen, S, Uusimäki, A, Rämet, M et al.. Proprotein convertase subtilisin/kexin type 7 (PCSK7) is essential for the zebrafish development and bioavailability of transforming growth factor β1a (TGFβ1a). J. Biol. Chem. 2013;288 (51):36610-23. doi: 10.1074/jbc.M113.453183. PubMed PMID:24178295 PubMed Central PMC3868773.
- Brennan, CW, Verhaak, RG, McKenna, A, Campos, B, Noushmehr, H, Salama, SR et al.. The somatic genomic landscape of glioblastoma. Cell. 2013;155 (2):462-77. doi: 10.1016/j.cell.2013.09.034. PubMed PMID:24120142 PubMed Central PMC3910500.
- Leinonen, KA, Saramäki, OR, Furusato, B, Kimura, T, Takahashi, H, Egawa, S et al.. Loss of PTEN is associated with aggressive behavior in ERG-positive prostate cancer. Cancer Epidemiol. Biomarkers Prev. 2013;22 (12):2333-44. doi: 10.1158/1055-9965.EPI-13-0333-T. PubMed PMID:24083995 PubMed Central PMC4086660.
- Manninen, T, Huttunen, H, Ruusuvuori, P, Nykter, M. Leukemia prediction using sparse logistic regression. PLoS ONE. 2013;8 (8):e72932. doi: 10.1371/journal.pone.0072932. PubMed PMID:24023658 PubMed Central PMC3758279.
- Kong, L, Aho, KL, Granberg, K, Lund, R, Järvenpää, L, Seppälä, J et al.. ESTOOLS Data@Hand: human stem cell gene expression resource. Nat. Methods. 2013;10 (9):814-5. doi: 10.1038/nmeth.2576. PubMed PMID:23985726 .
- Liuksiala, T, Teittinen, KJ, Granberg, K, Heinäniemi, M, Annala, M, Mäki, M et al.. Overexpression of SNORD114-3 marks acute promyelocytic leukemia. Leukemia. 2014;28 (1):233-6. doi: 10.1038/leu.2013.250. PubMed PMID:23979522 .
- Lund, RJ, Emani, MR, Barbaric, I, Kivinen, V, Jones, M, Baker, D et al.. Karyotypically abnormal human ESCs are sensitive to HDAC inhibitors and show altered regulation of genes linked to cancers and neurological diseases. Stem Cell Res. 2013;11 (3):1022-36. doi: 10.1016/j.scr.2013.07.002. PubMed PMID:23941963 .
- Marttila, S, Jylhävä, J, Nevalainen, T, Nykter, M, Jylhä, M, Hervonen, A et al.. Transcriptional analysis reveals gender-specific changes in the aging of the human immune system. PLoS ONE. 2013;8 (6):e66229. doi: 10.1371/journal.pone.0066229. PubMed PMID:23776639 PubMed Central PMC3679079.
- Zhang, W, Nykter, M, Chen, K. Next generation sequencing applications in cancer research. Cancer Lett. 2013;340 (2):149-50. doi: 10.1016/j.canlet.2013.05.026. PubMed PMID:23764479 .
- Cancer Genome Atlas Research Network, Kandoth, C, Schultz, N, Cherniack, AD, Akbani, R, Liu, Y et al.. Integrated genomic characterization of endometrial carcinoma. Nature. 2013;497 (7447):67-73. doi: 10.1038/nature12113. PubMed PMID:23636398 PubMed Central PMC3704730.
- Heinäniemi, M, Nykter, M, Kramer, R, Wienecke-Baldacchino, A, Sinkkonen, L, Zhou, JX et al.. Gene-pair expression signatures reveal lineage control. Nat. Methods. 2013;10 (6):577-83. doi: 10.1038/nmeth.2445. PubMed PMID:23603899 PubMed Central PMC4131748.
- Sadot, A, Sarbu, S, Kesseli, J, Amir-Kroll, H, Zhang, W, Nykter, M et al.. Information-theoretic analysis of the dynamics of an executable biological model. PLoS ONE. 2013;8 (3):e59303. doi: 10.1371/journal.pone.0059303. PubMed PMID:23527156 PubMed Central PMC3602105.
- Mäki-Marttunen, T, Kesseli, J, Nykter, M. Balance between noise and information flow maximizes set complexity of network dynamics. PLoS ONE. 2013;8 (3):e56523. doi: 10.1371/journal.pone.0056523. PubMed PMID:23516395 PubMed Central PMC3596377.
- Yang, D, Sun, Y, Hu, L, Zheng, H, Ji, P, Pecot, CV et al.. Integrated analyses identify a master microRNA regulatory network for the mesenchymal subtype in serous ovarian cancer. Cancer Cell. 2013;23 (2):186-99. doi: 10.1016/j.ccr.2012.12.020. PubMed PMID:23410973 PubMed Central PMC3603369.
- Aghaeepour, N, Finak, G, FlowCAP Consortium, DREAM Consortium, Hoos, H, Mosmann, TR et al.. Critical assessment of automated flow cytometry data analysis techniques. Nat. Methods. 2013;10 (3):228-38. doi: 10.1038/nmeth.2365. PubMed PMID:23396282 PubMed Central PMC3906045.
- Annala, MJ, Parker, BC, Zhang, W, Nykter, M. Fusion genes and their discovery using high throughput sequencing. Cancer Lett. 2013;340 (2):192-200. doi: 10.1016/j.canlet.2013.01.011. PubMed PMID:23376639 PubMed Central PMC3675181.
- Weirauch, MT, Cote, A, Norel, R, Annala, M, Zhao, Y, Riley, TR et al.. Evaluation of methods for modeling transcription factor sequence specificity. Nat. Biotechnol. 2013;31 (2):126-34. doi: 10.1038/nbt.2486. PubMed PMID:23354101 PubMed Central PMC3687085.
- Parker, BC, Annala, MJ, Cogdell, DE, Granberg, KJ, Sun, Y, Ji, P et al.. The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma. J. Clin. Invest. 2013;123 (2):855-65. doi: 10.1172/JCI67144. PubMed PMID:23298836 PubMed Central PMC3561838.
- Patel, LR, Nykter, M, Chen, K, Zhang, W. Cancer genome sequencing: understanding malignancy as a disease of the genome, its conformation, and its evolution. Cancer Lett. 2013;340 (2):152-60. doi: 10.1016/j.canlet.2012.10.018. PubMed PMID:23111104 PubMed Central PMC3632661.
- Moore, LM, Kivinen, V, Liu, Y, Annala, M, Cogdell, D, Liu, X et al.. Transcriptome and small RNA deep sequencing reveals deregulation of miRNA biogenesis in human glioma. J. Pathol. 2013;229 (3):449-59. doi: 10.1002/path.4109. PubMed PMID:23007860 PubMed Central PMC3857031.
Publications 2012
- Patel, LR, Nykter, M, Chen, K, Zhang, W. Cancer genome sequencing: understanding malignancy as a disease of the genome, its conformation, and its evolution. Cancer Lett. 2013;340 (2):152-60. doi: 10.1016/j.canlet.2012.10.018. PubMed PMID:23111104 PubMed Central PMC3632661.
- Holmes, KM, Annala, M, Chua, CY, Dunlap, SM, Liu, Y, Hugen, N et al.. Insulin-like growth factor-binding protein 2-driven glioma progression is prevented by blocking a clinically significant integrin, integrin-linked kinase, and NF-κB network. Proc. Natl. Acad. Sci. U.S.A. 2012;109 (9):3475-80. doi: 10.1073/pnas.1120375109. PubMed PMID:22345562 PubMed Central PMC3295320.
Publications 2011
- Yang, J, Ylipää, A, Sun, Y, Zheng, H, Chen, K, Nykter, M et al.. Genomic and molecular characterization of malignant peripheral nerve sheath tumor identifies the IGF1R pathway as a primary target for treatment. Clin. Cancer Res. 2011;17 (24):7563-73. doi: 10.1158/1078-0432.CCR-11-1707. PubMed PMID:22042973 PubMed Central PMC3243813.
- Mäki-Marttunen, T, Aćimović, J, Nykter, M, Kesseli, J, Ruohonen, K, Yli-Harja, O et al.. Information diversity in structure and dynamics of simulated neuronal networks. Front Comput Neurosci. 2011;5 :26. doi: 10.3389/fncom.2011.00026. PubMed PMID:21852970 PubMed Central PMC3151619.
- Annala, M, Laurila, K, Lähdesmäki, H, Nykter, M. A linear model for transcription factor binding affinity prediction in protein binding microarrays. PLoS ONE. 2011;6 (5):e20059. doi: 10.1371/journal.pone.0020059. PubMed PMID:21637853 PubMed Central PMC3102690.
- Cheng, H, Zhang, L, Cogdell, DE, Zheng, H, Schetter, AJ, Nykter, M et al.. Circulating plasma MiR-141 is a novel biomarker for metastatic colon cancer and predicts poor prognosis. PLoS ONE. 2011;6 (3):e17745. doi: 10.1371/journal.pone.0017745. PubMed PMID:21445232 PubMed Central PMC3060165.
- Yli-Harja, O, Ylipää, A, Nykter, M, Zhang, W. Cancer systems biology: signal processing for cancer research. Chin J Cancer. 2011;30 (4):221-5. . PubMed PMID:21439242 PubMed Central PMC4013347.
- Ylipää, A, Yli-Harja, O, Zhang, W, Nykter, M. A systems biological approach to identify key transcription factors and their genomic neighborhoods in human sarcomas. Chin J Cancer. 2011;30 (1):27-40. . PubMed PMID:21192842 PubMed Central PMC4012261.
- Ylipää, A, Hunt, KK, Yang, J, Lazar, AJ, Torres, KE, Lev, DC et al.. Integrative genomic characterization and a genomic staging system for gastrointestinal stromal tumors. Cancer. 2011;117 (2):380-9. doi: 10.1002/cncr.25594. PubMed PMID:20818650 PubMed Central PMC3008331.
Publications 2010
- Ylipää, A, Hunt, KK, Yang, J, Lazar, AJ, Torres, KE, Lev, DC et al.. Integrative genomic characterization and a genomic staging system for gastrointestinal stromal tumors. Cancer. 2011;117 (2):380-9. doi: 10.1002/cncr.25594. PubMed PMID:20818650 PubMed Central PMC3008331.
- Yang, D, Ylipaa, A, Yang, J, Hunt, K, Pollock, R, Trent, J et al.. An integrated study of aberrant gene copy number and gene expression in GIST and LMS. Technol. Cancer Res. Treat. 2010;9 (2):171-8. doi: 10.1177/153303461000900206. PubMed PMID:20218739 .
- Galas, DJ, Nykter, M, Carter, GW, Price, ND, Shmulevich, I. Biological Information as Set-Based Complexity. IEEE Trans Inf Theory. 2010;56 (2):667-677. doi: 10.1109/TIT.2009.2037046. PubMed PMID:27857450 PubMed Central PMC5110148.
Publications 2009
- Nykter, M, Lähdesmäki, H, Rust, A, Thorsson, V, Shmulevich, I. A data integration framework for prediction of transcription factor targets. Ann. N. Y. Acad. Sci. 2009;1158 :205-14. doi: 10.1111/j.1749-6632.2008.03758.x. PubMed PMID:19348642 PubMed Central PMC2771581.
- Litvak, V, Ramsey, SA, Rust, AG, Zak, DE, Kennedy, KA, Lampano, AE et al.. Function of C/EBPdelta in a regulatory circuit that discriminates between transient and persistent TLR4-induced signals. Nat. Immunol. 2009;10 (4):437-43. doi: 10.1038/ni.1721. PubMed PMID:19270711 PubMed Central PMC2780024.
Publications 2008
- Nykter, M, Price, ND, Larjo, A, Aho, T, Kauffman, SA, Yli-Harja, O et al.. Critical networks exhibit maximal information diversity in structure-dynamics relationships. Phys. Rev. Lett. 2008;100 (5):058702. doi: 10.1103/PhysRevLett.100.058702. PubMed PMID:18352443 .
- Nykter, M, Price, ND, Aldana, M, Ramsey, SA, Kauffman, SA, Hood, LE et al.. Gene expression dynamics in the macrophage exhibit criticality. Proc. Natl. Acad. Sci. U.S.A. 2008;105 (6):1897-900. doi: 10.1073/pnas.0711525105. PubMed PMID:18250330 PubMed Central PMC2538855.
Publications 2007
- Niemistö, A, Nykter, M, Aho, T, Jalovaara, H, Marjanen, K, Ahdesmäki, M et al.. Computational methods for estimation of cell cycle phase distributions of yeast cells. EURASIP J Bioinform Syst Biol. 2007; :46150. doi: 10.1155/2007/46150. PubMed PMID:18354733 PubMed Central PMC3171340.
- Ruusuvuori, P, Nykter, M, Mäkiraatikka, E, Lehmussola, A, Korpelainen, T, Erkkilä, T et al.. Microarray simulator as educational tool. Conf Proc IEEE Eng Med Biol Soc. 2007;2007 :5920-3. doi: 10.1109/IEMBS.2007.4353695. PubMed PMID:18003361 .
Publications 2006
- Harjunpää, A, Taskinen, M, Nykter, M, Karjalainen-Lindsberg, ML, Nyman, H, Monni, O et al.. Differential gene expression in non-malignant tumour microenvironment is associated with outcome in follicular lymphoma patients treated with rituximab and CHOP. Br. J. Haematol. 2006;135 (1):33-42. doi: 10.1111/j.1365-2141.2006.06255.x. PubMed PMID:16925574 .
- Nykter, M, Aho, T, Ahdesmäki, M, Ruusuvuori, P, Lehmussola, A, Yli-Harja, O et al.. Simulation of microarray data with realistic characteristics. BMC Bioinformatics. 2006;7 :349. doi: 10.1186/1471-2105-7-349. PubMed PMID:16848902 PubMed Central PMC1574357.
- Nykter, M, Hunt, KK, Pollock, RE, El-Naggar, AK, Taylor, E, Shmulevich, I et al.. Unsupervised analysis uncovers changes in histopathologic diagnosis in supervised genomic studies. Technol. Cancer Res. Treat. 2006;5 (2):177-82. doi: 10.1177/153303460600500209. PubMed PMID:16551137 .