Publications
2026
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Nb-Doped g‑C<sub>3</sub>N<sub>4</sub>: A Highly Efficient and Stable Catalyst for Oxidative Desulfurization
This study reports the synthesis and application of niobium-doped graphitic carbon nitride as a high-performance catalyst for oxidative desulfurization (ODS) of fuels. The 10-NbCN material, prepared via pyrolysis, exhibits Nb species that are highly dispersed at the atomic level within the g-C(3)N(4) framework, as confirmed by XRD, FTIR, and TEM. Under optimized conditions (60 °C, O/S = 20:1, 4 g L^(-1) catalyst), 96% removal of dibenzothiophene (DBT) is achieved within 120 min, outperforming... -
Purification and characterization of peroxidase from foxtail millet (<em>Setaria italica</em>)
Foxtail millet peroxidase (POD) may contribute to quality deterioration during processing and storage, but its biochemical and thermal properties remain insufficiently characterized. In this study, POD was purified from foxtail millet by ammonium sulfate fractionation, dialysis, and a single SP-Sepharose cation-exchange step and identified by nanoLC-MS/MS. The purified enzyme had an apparent molecular mass of 37.7 kDa and a specific activity of 315.21 ± 11.02 U/mg, corresponding to a 62.74-fold... -
A triple-responsive smart controlled-release system for antifungal volatiles: toward sustainable agriculture via pathogen-targeted control and crop growth promotion
Fungal contamination causes substantial global food loss and waste. Among these, tomato gray mold caused by Botrytis cinerea is particularly severe, leading to a global reduction in tomato yield of 10-50%. Meanwhile, the overuse of conventional chemical fungicides has triggered an unprecedented crisis of resistance and ecological risks, seriously threatening food safety and sustainable agricultural development. To address this issue, this study constructed a triple-responsive smart... -
Quantum refinement can be used to improve time-resolved crystallographic structures
Time-resolved serial crystallography has been shown to be a powerful technique to study enzyme reactions. In such studies, a reaction is triggered within the crystal and data are collected at different timepoints. A problem with this approach is that the synchronization is never perfect and therefore the structures at different timepoints typically contain a mixture of states in the active site, for example involving unreacted states, intermediates and products. Interpreting the electron density... -
Ion-Specific Interfacial Hydration Beyond Classical Chaotropicity
Ion specificity at charged aqueous interfaces plays important roles in many natural and technological phenomena. While ion-specific effects have been frequently investigated for halides and other molecular anions, the bis(trifluoromethanesulfonyl)imide (TFSI) anion, a common ionic liquid anion, has been rarely investigated in aqueous interfaces. However, TFSI-water interactions are highly important in rare earth element separations. Here, using sum-frequency generation (SFG) spectroscopy, we... -
N-doped sulfonated biochar as a solid acid catalyst for biodiesel production via esterification: preparation, response surface optimization, kinetics, and mechanism
The synergistic valorization of waste molasses and chitin is pivotal for establishing a sustainable and economically feasible route to produce biodiesel. Herein, a novel N-doped sulfonated biochar catalyst (110-6-SO(3)H-KOH-700NC(2)) was synthesized via KOH activation, nitrogen doping, and subsequent sulfonation, and systematically evaluated for the esterification of oleic acid (OA) with methanol. The 110-6-SO(3)H-KOH-700NC(2) catalyst exhibited an ultra-high specific surface area of 2970.18... -
International Multiprofessional Expert Consensus on Acute Minor Wounds: A Practical Decision Framework
Acute minor wounds are among the most common injuries encountered in daily life, affecting individuals of all ages and frequently managed in home, pharmacy and primary care settings. Despite their high prevalence and potential for preventable complications, most recommendations focus on chronic or complex wounds, leaving a gap in practical, evidence-informed guidance for acute minor wounds. This international consensus convened wound care professionals from four continents to develop a pragmatic... -
<em>Cyperus scariosus-</em>mediated synthesis of nickel-based nanomaterials for photocatalytic methylene blue degradation, antibacterial and antioxidant activities
The root extract of Cyperus scariosus (C. scariosus) was prepared in water and it was used for the synthesis of a nanomaterial based on nickel. The synthesized nanomaterial was tested for its photocatalytic, antibacterial and antioxidant properties. The maximum absorption wavelength obtained by the UV-visible analysis was ∼292 nm, with an apparent optical transition of ∼3.6 eV. The presence of crystalline features containing nickel and oxygen was confirmed by XRD, FTIR and EDX; however,... -
Head-mounted camera for reconstructing outdoor behavior in freely flying birds
Capturing the fine details of behavior when animals perform complex tasks, such as prey pursuit and capture, in natural environments is a challenging endeavor. For birds of prey, commonly used tracking approaches, such as lightweight GPS and inertial measurement units, cannot simultaneously track the bird's position and the fine details of body part motion or moving external objects. Here we designed a head-mounted, tetherless, 4π camera system which, combined with a high-resolution... -
Nitrogen-doped hierarchically porous bio-scaffold with a coordination-active interface for superior pertechnetate (TcO<sub>4</sub><sup>-</sup>) sequestration
Long-lived and highly mobile pertechnetate (TcO(4)^(-)) poses a persistent challenge for radioactive-wastewater treatment, particularly in the presence of competing anions. Herein, a nitrogen-doped architected super-porous bio-scaffold (NASB) was prepared from Alocasia macrorrhiza stems. NASB exhibited a high TcO(4)^(-) adsorption capacity, with rapid and spontaneous uptake that followed a pseudo-second-order kinetic model. It enabled preferential TcO(4)^(-) uptake even in the presence of a... -
Robotic winding of wet-spun fibers for biofabrication of aligned, perfusable, muscle-based tissue
Structural alignment of muscle and integrated vasculature enables the function of geometrically complex tissues in the body, such as the gastroesophageal junction and the ventricles. However, replicating this complexity is an ongoing challenge. Described here is the wet-spun & robotically articulated placement (WRAP) method for deposition of aligned cellular fibers on scaffolds, resulting in large structures fabricated from the inside-out. WRAP enables complex, multi-oriented muscle and vascular... -
Spatial transcriptomics identifies tumor-intrinsic and stromal programs associated with immune exclusion in NSCLC
Immune checkpoint blockade (ICB) has reshaped the treatment of advanced non-small cell lung cancer (NSCLC), yet durable benefit remains limited to a subset of patients. One major pattern of resistance is immune exclusion, in which CD8+ T cells accumulate in stromal regions but fail to penetrate tumor nests. Here, using discovery and non-overlapping internal validation cohorts of ICB-treated NSCLC patients, we show that spatial CD8+ T-cell exclusion is associated with lower objective response... -
Rational design of hydrophobic deep eutectic solvents tunes the catalytic pocket of lipase for the sustainable synthesis of structural lipids
The global epidemic of metabolic diseases has accelerated the demand for functional structured lipids, particularly medium- and long-chain triacylglycerols (MLCTs), which have attracted significant attention due to their dual advantages of rapid energy supply and provision of essential fatty acids. However, the enzymatic synthesis of MLCTs has long been constrained by the solvent-enzyme compatibility paradox, wherein solvents capable of effectively dissolving hydrophobic substrates tend to strip... -
Hydrothermal degradation mechanism and kinetics of 4'-O-methylpyridoxine and its glucoside in Ginkgo biloba L. seeds
The neurotoxic vitamin B(6) derivatives 4'-O-methylpyridoxine (MPN) and 4'-O-methylpyridoxine-5'-glucoside (MPNG) are the primary safety concerns limiting the utilization of nutrient-rich Ginkgo biloba L. seeds (GBSs). In this study, the hydrothermal degradation behavior of MPN and MPNG was systematically investigated. The degradation products were identified as non-toxic pyridoxine (PN), pyridoxine-5'-glucoside (PNG), and methanol using HPLC-IT-TOF-MS, ¹H NMR, and GC. Both toxins undergo ether... -
Single-Cell Characterization of SPP1-Expressing Macrophages and Their Predicted Interactions With T Cells in the Breast Cancer Bone Metastatic Microenvironment
CONCLUSION: This study provides a single-cell characterization of the breast cancer bone-metastatic microenvironment, identifying an SPP1-expressing macrophage subset (Mac-SPP1) and predicting its interactions with CD4-S100A9 and CD8-GZMK T cells. Because the bone-metastatic and primary/normal specimens derive from different datasets, these findings are descriptive and cannot be attributed to metastatic progression alone and require experimental validation and confirmation in cohorts that... -
Quantum engineering design of Li, Na, Bi, and La-decorated Al<sub>12</sub>N<sub>12</sub> nanocages from composite density functional theory perspective: toward tunable methimazole nanocarrier design for hyperthyroidism therapy
Hyperthyroidism treatment with radioactive iodine therapy and surgery poses significant hazards. The safest mode of treatment is oral delivery, with methimazole being one of the options. To minimize side effects, a safe and efficient drug delivery system is necessary. Nanomaterial-based drug delivery systems are developed with an Al(12)N(12) nanocage as a promising candidate due to its unique structure, stability, efficient mechanism, and high adsorption performance. However, it has a relatively... -
Retrograde intrarenal surgery (RIRS) with Holmium: YAG laser and Magneto technology versus Thulium Fiber Laser: it's time to compare
CONCLUSIONS: Both Magneto and TFL provided safe and effective lithotripsy during RIRS. Magneto achieved comparable ablation rate while requiring less delivered energy, improving laser ablation efficiency and providing a higher SFR. -
A brain stem tumor with visual discomfort
No abstract -
A mind-body intervention to improve recovery for patients with chronic hip joint-related pain: Protocol for a feasibility randomized controlled trial
INTRODUCTION: Current treatments for non-arthritic hip joint-related pain (HRP) follow a biomedical model that largely disregards psychological factors such as pain catastrophizing, kinesiophobia, and self-efficacy despite evidence of their pivotal role in recovery. These maladaptive psychological responses to pain are a barrier to rehabilitation and physical activity, leaving a critical gap in care. An intervention integrating mind-body techniques alongside rehabilitation is needed. Thus, this... -
Integrated experimental and machine learning-driven multi-objective optimization for phenol removal via silica aerogel/ZSM-5 nanocomposite: Isotherm and kinetic analysis, thermodynamic insights and pareto-based process design
Phenol is a highly toxic pollutant frequently detected in industrial wastewater. This study presents the first investigation of a hydrophilic silica aerogel/ZSM-5 nanocomposite for phenol adsorption, integrated with advanced machine-learning modeling and multi-objective optimization. Silica aerogel was synthesized via an ambient-pressure sol-gel route and combined with hydrothermally prepared ZSM-5. The 75:25 aerogel/ZSM-5 composite showed the highest surface area and adsorption performance...
2025
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A triple-responsive smart controlled-release system for antifungal volatiles: toward sustainable agriculture via pathogen-targeted control and crop growth promotion
Fungal contamination causes substantial global food loss and waste. Among these, tomato gray mold caused by Botrytis cinerea is particularly severe, leading to a global reduction in tomato yield of 10-50%. Meanwhile, the overuse of conventional chemical fungicides has triggered an unprecedented crisis of resistance and ecological risks, seriously threatening food safety and sustainable agricultural development. To address this issue, this study constructed a triple-responsive smart... -
Single-Cell Characterization of SPP1-Expressing Macrophages and Their Predicted Interactions With T Cells in the Breast Cancer Bone Metastatic Microenvironment
CONCLUSION: This study provides a single-cell characterization of the breast cancer bone-metastatic microenvironment, identifying an SPP1-expressing macrophage subset (Mac-SPP1) and predicting its interactions with CD4-S100A9 and CD8-GZMK T cells. Because the bone-metastatic and primary/normal specimens derive from different datasets, these findings are descriptive and cannot be attributed to metastatic progression alone and require experimental validation and confirmation in cohorts that... -
Dynamic Selenocarbamate Chemistry Enables Reconfigurable 3D-Printed Materials With Tunable Refractive Index
Dynamic covalent chemistry has emerged as a powerful strategy for imparting reprocessability and adaptability to polymer networks; however, the range of dynamic covalent bonds available for additive manufacturing remains limited. Herein, we integrate selenocarbamate linkages into photopolymerizable three-dimensional (3D) printing networks. Small-molecule studies reveal efficient selenocarbamate exchange with an activation energy of 44 kJ mol^(-1), confirming its dynamic nature. A... -
Nickel-Zinc Catalysts Favor CO Production via Carbide Formation in CO2 Hydrogenation
Achieving high CO selectivity in CO2 hydrogenation with non-noble metal catalysts remains challenging. Here, we report a simple and cost-effective in situ synthesis of nickel-zinc carbide (Ni3ZnC) from Ni species supported on ZnO under reaction conditions. A higher amount of Ni3ZnC forms in the calcined NiO/ZnO catalyst compared to the prereduced Ni/ZnO system. Thermodynamic analysis reveals a strong driving force for Ni3ZnC formation via NiO/ZnO coreduction (ΔE ≈ -455 kJ mol-1), which is more... -
Synthetic Microbial Communities Regulate Rhizosphere Microorganisms to Ameliorate Arid Farmland Soil and Improve Onion Growth across Growth Stages
Although microbial inoculants exhibit plant-growth-promoting potential, their regulatory mechanisms remain unclear. Using absolute quantitative sequencing, we explored how the fermentation broth of synthetic microbial communities (SynComs) built from six strains modulated onion rhizosphere microecology throughout the growth period. SynComs broth elevated soil enzyme activities and available nutrients at specific growth stages. Absolute abundances of beneficial bacteria Nitrospira and... -
Stereoselective Synthesis of (-)-Ambrox via Metalloporphyrin-Catalyzed C(sp3)-H Bond Oxidation of Hydrocarbons
Ambrox is a naturally tricyclic terpenoid furan, which is mainly responsible for the characteristic pleasant odor of ambergris. A concise synthesis of racemic ambrox was accomplished in a ten-step linear sequence starting from commercially available dihydroboronal with an overall yield of 20.7%. The synthetic strategy features a Brønsted acid-mediated biomimetic cyclization of a monocyclic enol acetate and a late-stage C(sp3)-H bond hydroxylation of hydrocarbons catalyzed by an activated... -
Coupled Bulk-Interfacial Modulation Enables Suppressed Conduction Loss in High-Temperature Polymer Capacitors
Polymer film capacitors are widely used in electronic devices and power systems, yet their energy storage performance (ESP) deteriorates significantly under harsh operating conditions. Here, we propose a synergistic strategy that integrates bulk physical crosslinking with interfacial plasma regulation to suppress conduction loss and enhance high-temperature dielectric performance. 4-cyanobenzaldehyde (4-CZ) is incorporated into a polyetherimide (PEI) matrix to construct a noncovalent,... -
Aetiology-Specific Pancreatic Enzyme Dose Requirements and Treatment Outcomes in Pancreatic Exocrine Insufficiency: The Multicentre EURO-PEI Registry
CONCLUSIONS: PERT dose requirements vary substantially by PEI aetiology, supporting aetiology-aware starting doses, early reassessment, and individualised optimisation in high-risk groups. -
Virtual Screening and Molecular Dynamics Simulations Identifying Natural Product-Derived Cathepsin K Inhibitors as Potential Therapeutics for Osteoporosis
Osteoporosis is a prevalent skeletal disorder characterized by excessive bone resorption and an increased risk of fragility fracture. Cathepsin K (CatK), a lysosomal cysteine protease predominantly expressed in osteoclasts, is an established target for anti-resorptive drug development. Here, an integrated computational workflow comprising virtual screening, molecular docking, 300 ns molecular dynamics (MD) simulations, molecular mechanics/Poisson-Boltzmann surface area (MM/PBSA) calculations,... -
Retrospective Single Center Assessment of Routes to Penile Cancer Diagnosis and the Role of Penile Biopsy
CONCLUSION: The CPP identifies a higher proportion of malignancies but with a low overall conversion ratio, and some cancers are still diagnosed outside the pathway. Penile biopsy is safe and essential for accurate diagnosis due to low clinical-histological concordance, with added therapeutic value. Continued focused penile biopsy use, including re-biopsy in uncertain cases, is warranted to ensure optimal management and oncological safety. -
Degenerative lumbosacral spondylolisthesis: Instability as the primary pathology and stabilization as definitive treatment. Experience with 28 cases treated by only fixation without any decompression
CONCLUSIONS: "Vertical" spinal instability is the principal pathogenic factor in degenerative lumbar spondylolisthesis and associated canal stenosis. Degenerative lumbar spondylolisthesis rarely exists in isolation and commonly involves multisegmental instability. Stabilization of unstable segments alone is the treatment, and decompressive procedures are unnecessary. -
STAT1: a central hub linking ferroptosis and inflammation in hepatic ischemia-reperfusion injury
Hepatic ischemia-reperfusion injury (HIRI) remains an intractable perioperative complication of liver transplantation and hepatectomy, driven by two interdependent but historically segregated pathological cascades: iron-dependent ferroptotic parenchymal death and amplified sterile inflammatory signaling. A critical unmet gap in the field is identification of a single upstream molecular node capable of synchronously coordinating both injury programs. Building upon the foundational murine... -
Cognitive Behavior Therapy for Psychosis in People with Intellectual Disability-A Scoping Review
CONCLUSION: Cognitive behavior therapy for psychosis seems feasible for people with psychosis and intellectual disabilities, with only practical adjustments necessary. Randomized controlled trials are needed to study the efficacy of CBTp for this population. -
Exploration of multidimensional associations between craniomaxillofacial and dental arch structures
CONCLUSIONS: Significant correlations were identified between craniomaxillofacial structure and dental arch structure. Facial width, facial height, and mandibular body length were found to have strong effects on dental arch structure, particularly in the maxillary region (notably at the first molar). The craniomaxillofacial-dental arch system constitutes a complex, multilevel interactive network, suggesting that comprehensive orthodontic assessment should consider the relationships among these... -
From Solvent Design to Biological Response: Structure-Property Relationships of Edible Natural Deep Eutectic Solvents for the Extraction of <em>Nigella sativa</em> Bioactives
Edible Natural Deep Eutectic Solvents (NADES) offer a route to ready-to-use extracts without solvent removal. This study examined how rational formulation design influences physicochemical properties, extraction performance, energy efficiency, thermal behavior, and cytocompatibility during bioactive recovery from Nigella sativa seeds. Twelve formulations spanning malic acid-polyol, citric acid-polyol, binary polyol, and ternary acid-polyol families were evaluated under standardized...
2024
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Single cell and spatial transcriptomics highlight the interaction of club-like cells with immunosuppressive myeloid cells in prostate cancer
Prostate cancer treatment resistance is a significant challenge facing the field. Genomic and transcriptomic profiling have partially elucidated the mechanisms through which cancer cells escape treatment, but their relation toward the tumor microenvironment (TME) remains elusive. Here we present a comprehensive transcriptomic landscape of the prostate TME at multiple points in the standard treatment timeline employing single-cell RNA-sequencing and spatial transcriptomics data from 120 patients.... -
Protumoral lipid droplet-loaded macrophages are enriched in human glioblastoma and can be therapeutically targeted
Glioblastoma presents a formidable clinical challenge because of its complex microenvironment. Here, we characterized tumor-associated foam cells (TAFs), a type of lipid droplet-loaded macrophage, in human glioblastoma. Through extensive analyses of patient tumors, together with in vitro and in vivo investigations, we found that TAFs exhibit distinct protumorigenic characteristics related to hypoxia, mesenchymal transition, angiogenesis, and impaired phagocytosis, and their presence correlates... -
Development and epigenetic regulation of Atypical teratoid/rhabdoid tumors in the context of cell-of-origin and halted cell differentiation
Atypical teratoid/rhabdoid tumors (AT/RTs) are aggressive brain tumors primarily observed in infants. The only characteristic, recurrent genetic aberration of AT/RTs is biallelic inactivation of SMARCB1 (or SMARCA4). These genes are members of the mSWI/SNF chromatin-remodeling complex, which regulates various developmental processes, including neural differentiation. This review explores AT/RT subgroups regarding their distinct SMARCB1 loss-of-function mechanisms, molecular features, and patient... -
Previously reported CCDC26 risk variant and novel germline variants in GALNT13, AR, and MYO10 associated with familial glioma in Finland
Predisposing factors underlying familial aggregation of non-syndromic gliomas are still to be uncovered. Whole-exome sequencing was performed in four Finnish families with brain tumors to identify rare predisposing variants. A total of 417 detected exome variants and 102 previously reported glioma-related variants were further genotyped in 19 Finnish families with brain tumors using targeted sequencing. Rare damaging variants in GALNT13, MYO10 and AR were identified. Two families carried either... -
Aberrant DNA methylation distorts developmental trajectories in atypical teratoid/rhabdoid tumors
Atypical teratoid/rhabdoid tumors (AT/RTs) are pediatric brain tumors known for their aggressiveness and aberrant but still unresolved epigenetic regulation. To better understand their malignancy, we investigated how AT/RT-specific DNA hypermethylation was associated with gene expression and altered transcription factor binding and how it is linked to upstream regulation. Medulloblastomas, choroid plexus tumors, pluripotent stem cells, and fetal brain were used as references. A part of the... -
Motor dysfunction as a primary symptom predicts poor outcome: multicenter study of glioma symptoms
CONCLUSION: Primary and leading symptoms in diffuse gliomas are associated with prognoses in retrospective and prospective settings. Motor paresis was an independent prognostic factor for poor survival in multivariate analysis for grade 2-4 diffuse gliomas, especially in glioblastomas.
2023
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Motor dysfunction as a primary symptom predicts poor outcome: multicenter study of glioma symptoms
CONCLUSION: Primary and leading symptoms in diffuse gliomas are associated with prognoses in retrospective and prospective settings. Motor paresis was an independent prognostic factor for poor survival in multivariate analysis for grade 2-4 diffuse gliomas, especially in glioblastomas. -
Distinct transcriptomic profiles in children prior to the appearance of type 1 diabetes-linked islet autoantibodies and following enterovirus infection
Although the genetic basis and pathogenesis of type 1 diabetes have been studied extensively, how host responses to environmental factors might contribute to autoantibody development remains largely unknown. Here, we use longitudinal blood transcriptome sequencing data to characterize host responses in children within 12 months prior to the appearance of type 1 diabetes-linked islet autoantibodies, as well as matched control children. We report that children who present with insulin-specific... -
Genomic characterization of IDH-mutant astrocytoma progression to grade 4 in the treatment setting
As the progression of low-grade diffuse astrocytomas into grade 4 tumors significantly impacts patient prognosis, a better understanding of this process is of paramount importance for improved patient care. In this project, we analyzed matched IDH-mutant astrocytomas before and after progression to grade 4 from six patients (discovery cohort) with genome-wide sequencing, 21 additional patients with targeted sequencing, and 33 patients from Glioma Longitudinal AnalySiS cohort for validation. The... -
Early-onset grade 2-3 diffuse gliomas and schwannomas increase the risk of central nervous system tumors among the patients' relatives
CONCLUSIONS: The early onset of grade 2-3 diffuse gliomas is associated with an increased risk of similar tumor entities. Early-onset schwannomas dramatically increase CNS tumor risk with a broader tumor-type profile. In future studies, it would be important to identify the underlying shared hereditary factors that contribute to the development of familial diffuse gliomas.
2022
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Quantum refinement can be used to improve time-resolved crystallographic structures
Time-resolved serial crystallography has been shown to be a powerful technique to study enzyme reactions. In such studies, a reaction is triggered within the crystal and data are collected at different timepoints. A problem with this approach is that the synchronization is never perfect and therefore the structures at different timepoints typically contain a mixture of states in the active site, for example involving unreacted states, intermediates and products. Interpreting the electron density... -
Videographic Analysis of an Intervention to Improve Patient-Centered Care for People Living with Type 2 Diabetes: The QBSAFE Randomized Trial
CONCLUSIONS: QBSAFE cards led to small patient-centered changes to encounter conversations, promoting ones about treatment burden, without displacing metabolic control discussions. Future work will focus on assisting clinicians in responding more effectively to patient issues so that raising these could change plans of care. -
Estimating the Relative Vaccine Efficacy of mRNA-1010 to High-Dose Influenza Vaccine in Adults ≥65 Years Using a Correlate of Protection Framework
CONCLUSIONS: Based on this CoP framework, mRNA-1010 was projected to have higher VE than HD-IIV4 in adults ≥65 years of age across a range of simulated epidemiological conditions. -
Defining pediatric cervical spine clearance with computed tomography: A prospective observational study by the Western Pediatric Surgery Research Consortium and Western Trauma Association
CONCLUSIONS: In pediatric blunt trauma patients evaluated for cervical spine injury, CT is highly sensitive for detecting clinically significant injuries. These findings support pediatric cervical spine clearance based on a normal cervical spine CT. ( J Trauma Acute Care Surg . 2026;101: 844-857.). -
Capacitive-Dominant Ion Storage in Electronically Coupled Vanadium Hexacyanoferrate/rGO for Efficient Capacitive Deionization Devices
The rational design of electrodes with hierarchically interconnected porosity and abundant redox-active channels is essential for high-performance capacitive deionization (CDI). Herein, vanadium hexacyanoferrate (VHCF) is integrated with reduced graphene oxide (rGO) to demonstrate a strongly coupled intercalation-type hybrid electrode that exhibits a pronounced morphological evolution from densely aggregated particles to a rosette-like nanosheet architecture, significantly improving electrolyte... -
Influenza A/H3N2 epidemiology in England during the 2025 to 2026 season: a mathematical modelling study
CONCLUSIONS: The 2025/26 influenza season is characterised by early but not unusually rapid growth. Earlier growth does not systematically lead to especially large epidemics due to earlier susceptible depletion combined with a dampening effect from school holidays. Laboratory evidence for antibody escape does not directly translate to large reductions in population immunity, supporting the need for complementary real-time epidemiological analyses and modelling. -
Clinicopathological factors associated with brain metastases development among breast cancer patients receiving neoadjuvant chemotherapy
CONCLUSIONS: Among patients treated with NAC for early-stage BC, residual nodal disease, inflammatory BC, and HER2+ or triple-negative subtype are associated with a higher risk of BrM development. Whether BrM screening is warranted among patients with these high-risk features warrants evaluation. -
Retro-odontoid pseudotumor and subaxial spinal osteophytes: instability as the etiology and stabilization as the treatment. Illustrative cases
BACKGROUND: Retro-odontoid pseudotumors (ROPs) and subaxial cervical osteophytes are generally considered distinct causes of ventral neural compression. The authors hypothesize that both represent secondary changes related to underlying cervical spinal instability rather than primary pathological entities. -
Glucosyl Hesperidin Benefits in Primary Biliary Cholangitis: A Multicenter, Open-Label, Randomized Controlled Study
INTRODUCTION: Primary biliary cholangitis (PBC) has steadily increased in incidence, but its causes remain to be completely elucidated. Moreover, the potential for disease progression is not uncommon, especially when normalization of hepatobiliary enzyme levels is difficult, making the emergence of new treatments highly anticipated. We clarified the therapeutic effects of glucosyl hesperidin (G-Hes), which activates the antioxidant NRF2/KEAP1 pathway, on improving PBC pathophysiology. -
Measurement-Efficient Few-Shot Vibration Fault Diagnosis via Physics-Informed Self-Supervised Learning and Adaptive Early Stopping
Vibration-based fault diagnosis is widely used for rotating machinery health monitoring, but practical diagnosis is often limited by scarce fault labels and uncertain measurement length. Longer vibration records can improve decision reliability but increase sensing and computational cost, whereas overly short records may yield unreliable predictions under noise and measurement corruptions. This paper studies few-shot fault diagnosis as a measurement-constrained decision task, in which the model... -
Comparative Analysis of Porous Alkali-Activated Composites Modified with Commercial and Laboratory-Prepared Phase Change Materials
This study presents a comparative evaluation of geopolymer foams incorporating either commercially available shape-stabilized phase change materials (PCMs) or laboratory-developed diatomite-paraffin PCM granules with controlled particle size fractions ranging from 2.5 mm. All PCM variants were incorporated at a constant dosage of 7.5 wt.% to isolate the influence of PCM type on the properties of the resulting composites. The commercial materials comprised PX-4, PX15, and PX20... -
Efficacy of a Brief Educational Video for Patients Prescribed Latent Tuberculosis Treatment: A Randomized Trial in the United States
CONCLUSIONS: The LTBI video intervention was not associated with increased treatment initiation and completion in this study. Additional interventions are needed to improve patient knowledge and support LTBI treatment. -
Chlorogenic acid attenuates skin senescence and UVR-induced photoaging via the modulation of mitochondrial function
CONCLUSION: CGA promotes Col1 production and attenuates skin cellular senescence, with these effects being directly associated with mitochondrial regulation. Thus, CGA holds promise as a potent agent for preventing cellular senescence. -
Microbial next generation DNA sequencing of aspirated synovial fluid shows concordance with ICM criteria biomarkers for diagnosing periprosthetic joint infection in hip and knee arthroplasty
CONCLUSION: Microbial targeted NGS positivity was concordant with ICM minor criteria for PJI and should be considered a useful tool for diagnosis. There is a low risk of false positive detections comparable to ICM biomarkers. Elevated biomarkers in NGS positive: ICM negative samples may indicate infection occurring that is poorly captured by the three measured synovial biomarkers. Uncommon species are collectively common to PJI and NGS is uniquely positioned to detect such species as they are... -
Pan-European Commission on Climate and Health: recommendations for accelerating climate action for health
No abstract
2021
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Motor dysfunction as a primary symptom predicts poor outcome: multicenter study of glioma symptoms
CONCLUSION: Primary and leading symptoms in diffuse gliomas are associated with prognoses in retrospective and prospective settings. Motor paresis was an independent prognostic factor for poor survival in multivariate analysis for grade 2-4 diffuse gliomas, especially in glioblastomas. -
Chromatin and Epigenetic Dysregulation of Prostate Cancer Development, Progression, and Therapeutic Response
The dysregulation of chromatin and epigenetics has been defined as the overarching cancer hallmark. By disrupting transcriptional regulation in normal cells and mediating tumor progression by promoting cancer cell plasticity, this process has the ability to mediate all defined hallmarks of cancer. In this review, we collect and assess evidence on the contribution of chromatin and epigenetic dysregulation in prostate cancer. We highlight important mechanisms leading to prostate carcinogenesis,... -
CD109-GP130 interaction drives glioblastoma stem cell plasticity and chemoresistance through STAT3 activity
Glioma stem cells (GSCs) drive propagation and therapeutic resistance of glioblastomas, the most aggressive diffuse brain tumors. However, the molecular mechanisms that maintain the stemness and promote therapy resistance remain poorly understood. Here we report CD109/STAT3 axis as crucial for the maintenance of stemness and tumorigenicity of GSCs and as a mediator of chemoresistance. Mechanistically, CD109 physically interacts with glycoprotein 130 to promote activation of the IL-6/STAT3... -
Genetic and Epigenetic Characteristics of Inflammatory Bowel Disease-Associated Colorectal Cancer
CONCLUSIONS: Distinct mechanisms of WNT pathway dysregulation skew IBD-CRCs toward mesenchymal tumor subtype, which may affect prognosis and treatment options. Increased OSMR signaling may favor the establishment of mesenchymal tumors in patients with IBD.
2020
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Immunogenomic Landscape of Hematological Malignancies
No abstract -
Community Assessment of the Predictability of Cancer Protein and Phosphoprotein Levels from Genomics and Transcriptomics
Cancer is driven by genomic alterations, but the processes causing this disease are largely performed by proteins. However, proteins are harder and more expensive to measure than genes and transcripts. To catalyze developments of methods to infer protein levels from other omics measurements, we leveraged crowdsourcing via the NCI-CPTAC DREAM proteogenomic challenge. We asked for methods to predict protein and phosphorylation levels from genomic and transcriptomic data in cancer patients. The... -
Immunogenomic Landscape of Hematological Malignancies
Understanding factors that shape the immune landscape across hematological malignancies is essential for immunotherapy development. We integrated over 8,000 transcriptomes and 2,000 samples with multilevel genomics of hematological cancers to investigate how immunological features are linked to cancer subtypes, genetic and epigenetic alterations, and patient survival, and validated key findings experimentally. Infiltration of cytotoxic lymphocytes was associated with TP53 and... -
Glioblastoma Multiforme Stem Cell Cycle Arrest by Alkylaminophenol Through the Modulation of EGFR and CSC Signaling Pathways
Cancer stem cells (CSCs), a small subpopulation of cells existing in the tumor microenvironment promoting cell proliferation and growth. Targeting the stemness of the CSC population would offer a vital therapeutic opportunity. 3,4-Dihydroquinolin-1(2H)-yl)(p-tolyl)methyl)phenol (THTMP), a small synthetic phenol compound, is proposed to play a significant role in controlling the CSC proliferation and survival. We assessed the potential therapeutic effects of THTMP on glioblastoma multiforme (GBM)... -
Moderate-to-strong expression of FGFR3 and TP53 alterations in a subpopulation of choroid plexus tumors
Deregulation of fibroblast growth factor receptor (FGFR) signaling is tightly associated with numerous human malignancies, including cancer. Indeed, FGFR inhibitors are being tested as anti-tumor drugs in clinical trials. Among gliomas, FGFR3 fusions occur in IDH wild-type diffuse gliomas leading to high FGFR3 protein expression and both, FGFR3 and FGFR1, show elevated expression in aggressive ependymomas. The aim of this study was to uncover the expression of FGFR1 and FGFR3 proteins in choroid...
2019
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Moderate-to-strong expression of FGFR3 and TP53 alterations in a subpopulation of choroid plexus tumors
Deregulation of fibroblast growth factor receptor (FGFR) signaling is tightly associated with numerous human malignancies, including cancer. Indeed, FGFR inhibitors are being tested as anti-tumor drugs in clinical trials. Among gliomas, FGFR3 fusions occur in IDH wild-type diffuse gliomas leading to high FGFR3 protein expression and both, FGFR3 and FGFR1, show elevated expression in aggressive ependymomas. The aim of this study was to uncover the expression of FGFR1 and FGFR3 proteins in choroid... -
Data-driven characterization of molecular phenotypes across heterogeneous sample collections
Existing large gene expression data repositories hold enormous potential to elucidate disease mechanisms, characterize changes in cellular pathways, and to stratify patients based on molecular profiles. To achieve this goal, integrative resources and tools are needed that allow comparison of results across datasets and data types. We propose an intuitive approach for data-driven stratifications of molecular profiles and benchmark our methodology using the dimensionality reduction algorithm... -
Hemap: An Interactive Online Resource for Characterizing Molecular Phenotypes across Hematologic Malignancies
Large collections of genome-wide data can facilitate the characterization of disease states and subtypes, permitting pan-cancer analysis of molecular phenotypes and evaluation of disease context for new therapeutic approaches. We analyzed 9,544 transcriptomes from more than 30 hematologic malignancies, normal blood cell types, and cell lines, and showed that disease types could be stratified in a data-driven manner. We then identified cluster-specific pathway activity, new biomarkers, and in... -
Modes of immunosuppression in glioblastoma microenvironment
No abstract
2018
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Motor dysfunction as a primary symptom predicts poor outcome: multicenter study of glioma symptoms
CONCLUSION: Primary and leading symptoms in diffuse gliomas are associated with prognoses in retrospective and prospective settings. Motor paresis was an independent prognostic factor for poor survival in multivariate analysis for grade 2-4 diffuse gliomas, especially in glioblastomas. -
Chromatin and Epigenetic Dysregulation of Prostate Cancer Development, Progression, and Therapeutic Response
The dysregulation of chromatin and epigenetics has been defined as the overarching cancer hallmark. By disrupting transcriptional regulation in normal cells and mediating tumor progression by promoting cancer cell plasticity, this process has the ability to mediate all defined hallmarks of cancer. In this review, we collect and assess evidence on the contribution of chromatin and epigenetic dysregulation in prostate cancer. We highlight important mechanisms leading to prostate carcinogenesis,... -
Computational Characterization of Suppressive Immune Microenvironments in Glioblastoma
The immunosuppressive microenvironment in glioblastoma (GBM) prevents an efficient antitumoral immune response and enables tumor formation and growth. Although an understanding of the nature of immunosuppression is still largely lacking, it is important for successful cancer treatment through immune system modulation. To gain insight into immunosuppression in GBM, we performed a computational analysis to model relative immune cell content and type of immune response in each GBM tumor sample from... -
Erratum: Whole-exome sequencing identifies germline mutation in <em>TP53</em> and <em>ATRX</em> in a child with genomically aberrant AT/RT and her mother with anaplastic astrocytoma
No abstract -
Whole-exome sequencing identifies germline mutation in <em>TP53</em> and <em>ATRX</em> in a child with genomically aberrant AT/RT and her mother with anaplastic astrocytoma
Brain tumors typically arise sporadically and do not affect several family members simultaneously. In the present study, we describe clinical and genetic data from two patients, a mother and her daughter, with familial brain tumors. Exome sequencing revealed a germline missense mutation in the TP53 and ATRX genes in both cases, and a somatic copy-neutral loss of heterozygosity (LOH) in TP53 in both atypical teratoid/rhabdoid tumor (AT/RT) and astrocytoma tumors. ATRX mutation was associated with... -
NRF2, DJ1 and SNRX1 and their prognostic impact in astrocytic gliomas
Nuclear factor erythroid 2-related factor 2 (NRF2), DJ1 and sulfiredoxin 1 (SRXN1) are transcription factors which protect cells from the oxidative damage caused by reactive oxygen species and, on the other hand, are associated with resistance to cancer treatments. The immunohistochemical expression of NRF2, DJ1 and SRNX1 was assessed in human grade II-IV astrocytic gliomas. Their association to clinicopathologic and essential molecular factors was evaluated. The RNA expression levels and...
2017
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Nickel-Zinc Catalysts Favor CO Production via Carbide Formation in CO2 Hydrogenation
Achieving high CO selectivity in CO2 hydrogenation with non-noble metal catalysts remains challenging. Here, we report a simple and cost-effective in situ synthesis of nickel-zinc carbide (Ni3ZnC) from Ni species supported on ZnO under reaction conditions. A higher amount of Ni3ZnC forms in the calcined NiO/ZnO catalyst compared to the prereduced Ni/ZnO system. Thermodynamic analysis reveals a strong driving force for Ni3ZnC formation via NiO/ZnO coreduction (ΔE ≈ -455 kJ mol-1), which is more... -
Degenerative lumbosacral spondylolisthesis: Instability as the primary pathology and stabilization as definitive treatment. Experience with 28 cases treated by only fixation without any decompression
CONCLUSIONS: "Vertical" spinal instability is the principal pathogenic factor in degenerative lumbar spondylolisthesis and associated canal stenosis. Degenerative lumbar spondylolisthesis rarely exists in isolation and commonly involves multisegmental instability. Stabilization of unstable segments alone is the treatment, and decompressive procedures are unnecessary. -
Targeted Delivery of mRNA to the Heart via Extracellular Vesicles or Lipid Nanoparticles
Efficient and specific delivery of mRNA to target tissues is critical for maximising therapeutic benefits while minimising off-target effects and systemic toxicity. Systemic administration of mRNA using lipid nanoparticles (LNPs) or extracellular vesicles (EVs) typically leads to predominant accumulation in the liver. We hypothesised that cardiac-specific EVs could promote enhanced relative cardiac enrichment of delivered mRNA compared with non-cardiac EVs or LNPs. In mice, intravenous...