Publications

G Steven Bova – PELICAN Personalized Cancer Medicine
2020-2024

Search PubMed

  1. Kaljunen, H, Taavitsainen, S, Kaarijärvi, R, Takala, E, Paakinaho, V, Nykter, M et al.. Fanconi anemia pathway regulation by FANCI in prostate cancer. Front Oncol. 2023;13 :1260826. doi: 10.3389/fonc.2023.1260826. PubMed PMID:38023254 PubMed Central PMC10643534.
  2. Nurminen, A, Jaatinen, S, Taavitsainen, S, Högnäs, G, Lesluyes, T, Ansari-Pour, N et al.. Cancer origin tracing and timing in two high-risk prostate cancers using multisample whole genome analysis: prospects for personalized medicine. Genome Med. 2023;15 (1):82. doi: 10.1186/s13073-023-01242-y. PubMed PMID:37828555 PubMed Central PMC10571458.
  3. Sattari, M, Kohvakka, A, Moradi, E, Rauhala, H, Urhonen, H, Isaacs, WB et al.. Identification of long noncoding RNAs with aberrant expression in prostate cancer metastases. Endocr Relat Cancer. 2023;30 (8):. doi: 10.1530/ERC-22-0247. PubMed PMID:37140987 PubMed Central PMC10326635.
  4. Yakneen, S, Waszak, SM, PCAWG Technical Working Group, Gertz, M, Korbel, JO, PCAWG Consortium et al.. Author Correction: Butler enables rapid cloud-based analysis of thousands of human genomes. Nat Biotechnol. 2023;41 (4):577. doi: 10.1038/s41587-022-01554-1. PubMed PMID:36944844 PubMed Central PMC10110458.
  5. Rodriguez-Martin, B, Alvarez, EG, Baez-Ortega, A, Zamora, J, Supek, F, Demeulemeester, J et al.. Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition. Nat Genet. 2023;55 (6):1080. doi: 10.1038/s41588-023-01319-9. PubMed PMID:36944736 PubMed Central PMC10260396.
  6. Akdemir, KC, Le, VT, Chandran, S, Li, Y, Verhaak, RG, Beroukhim, R et al.. Author Correction: Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer. Nat Genet. 2023;55 (6):1079. doi: 10.1038/s41588-023-01318-w. PubMed PMID:36944735 PubMed Central PMC10260394.
  7. Zapatka, M, Borozan, I, Brewer, DS, Iskar, M, Grundhoff, A, Alawi, M et al.. Author Correction: The landscape of viral associations in human cancers. Nat Genet. 2023;55 (6):1077. doi: 10.1038/s41588-023-01316-y. PubMed PMID:36944734 PubMed Central PMC10260395.
  8. Cortés-Ciriano, I, Lee, JJ, Xi, R, Jain, D, Jung, YL, Yang, L et al.. Author Correction: Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing. Nat Genet. 2023;55 (6):1076. doi: 10.1038/s41588-023-01315-z. PubMed PMID:36944733 PubMed Central PMC10260391.
  9. Yuan, Y, Ju, YS, Kim, Y, Li, J, Wang, Y, Yoon, CJ et al.. Author Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers. Nat Genet. 2023;55 (6):1078. doi: 10.1038/s41588-023-01317-x. PubMed PMID:36944732 PubMed Central PMC10260393.
  10. Alexandrov, LB, Kim, J, Haradhvala, NJ, Huang, MN, Tian Ng, AW, Wu, Y et al.. Author Correction: The repertoire of mutational signatures in human cancer. Nature. 2023;614 (7948):E41. doi: 10.1038/s41586-022-05600-5. PubMed PMID:36697836 PubMed Central PMC9931578.
  11. Li, Y, Roberts, ND, Wala, JA, Shapira, O, Schumacher, SE, Kumar, K et al.. Author Correction: Patterns of somatic structural variation in human cancer genomes. Nature. 2023;614 (7948):E38. doi: 10.1038/s41586-022-05597-x. PubMed PMID:36697835 PubMed Central PMC9931568.
  12. ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium. Author Correction: Pan-cancer analysis of whole genomes. Nature. 2023;614 (7948):E39. doi: 10.1038/s41586-022-05598-w. PubMed PMID:36697834 PubMed Central PMC9931570.
  13. Gerstung, M, Jolly, C, Leshchiner, I, Dentro, SC, Gonzalez, S, Rosebrock, D et al.. Author Correction: The evolutionary history of 2,658 cancers. Nature. 2023;614 (7948):E42. doi: 10.1038/s41586-022-05601-4. PubMed PMID:36697833 PubMed Central PMC9931577.
  14. Rheinbay, E, Nielsen, MM, Abascal, F, Wala, JA, Shapira, O, Tiao, G et al.. Author Correction: Analyses of non-coding somatic drivers in 2,658 cancer whole genomes. Nature. 2023;614 (7948):E40. doi: 10.1038/s41586-022-05599-9. PubMed PMID:36697832 PubMed Central PMC9931557.
  15. PCAWG Transcriptome Core Group, Calabrese, C, Davidson, NR, Demircioğlu, D, Fonseca, NA, He, Y et al.. Author Correction: Genomic basis for RNA alterations in cancer. Nature. 2023;614 (7948):E37. doi: 10.1038/s41586-022-05596-y. PubMed PMID:36697831 PubMed Central PMC9931574.

Search PubMed

  1. Carlevaro-Fita, J, Lanzós, A, Feuerbach, L, Hong, C, Mas-Ponte, D, Pedersen, JS et al.. Author Correction: Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis. Commun Biol. 2022;5 (1):1347. doi: 10.1038/s42003-022-03769-z. PubMed PMID:36482178 PubMed Central PMC9732278.
  2. Rubanova, Y, Shi, R, Harrigan, CF, Li, R, Wintersinger, J, Sahin, N et al.. Author Correction: Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig. Nat Commun. 2022;13 (1):7567. doi: 10.1038/s41467-022-32336-7. PubMed PMID:36482170 PubMed Central PMC9731941.
  3. Sieverling, L, Hong, C, Koser, SD, Ginsbach, P, Kleinheinz, K, Hutter, B et al.. Author Correction: Genomic footprints of activated telomere maintenance mechanisms in cancer. Nat Commun. 2022;13 (1):7574. doi: 10.1038/s41467-022-32328-7. PubMed PMID:36481818 PubMed Central PMC9731961.
  4. Shuai, S, PCAWG Drivers and Functional Interpretation Working Group, Gallinger, S, Stein, LD, PCAWG Consortium. Author Correction: Combined burden and functional impact tests for cancer driver discovery using DriverPower. Nat Commun. 2022;13 (1):7571. doi: 10.1038/s41467-022-32343-8. PubMed PMID:36481739 PubMed Central PMC9732291.
  5. Cmero, M, Yuan, K, Ong, CS, Schröder, J, PCAWG Evolution and Heterogeneity Working Group, Corcoran, NM et al.. Author Correction: Inferring structural variant cancer cell fraction. Nat Commun. 2022;13 (1):7568. doi: 10.1038/s41467-022-32338-5. PubMed PMID:36481724 PubMed Central PMC9732297.
  6. Jiao, W, Atwal, G, Polak, P, Karlic, R, Cuppen, E, PCAWG Tumor Subtypes and Clinical Translation Working Group et al.. Author Correction: A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns. Nat Commun. 2022;13 (1):7573. doi: 10.1038/s41467-022-32329-6. PubMed PMID:36481665 PubMed Central PMC9732335.
  7. Paczkowska, M, Barenboim, J, Sintupisut, N, Fox, NS, Zhu, H, Abd-Rabbo, D et al.. Author Correction: Integrative pathway enrichment analysis of multivariate omics data. Nat Commun. 2022;13 (1):7570. doi: 10.1038/s41467-022-32342-9. PubMed PMID:36481658 PubMed Central PMC9731958.
  8. Zhang, Y, Chen, F, Fonseca, NA, He, Y, Fujita, M, Nakagawa, H et al.. Author Correction: High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations. Nat Commun. 2022;13 (1):7572. doi: 10.1038/s41467-022-32333-w. PubMed PMID:36481652 PubMed Central PMC9732340.
  9. Bhandari, V, Li, CH, Bristow, RG, Boutros, PC, PCAWG Consortium. Author Correction: Divergent mutational processes distinguish hypoxic and normoxic tumours. Nat Commun. 2022;13 (1):7569. doi: 10.1038/s41467-022-32339-4. PubMed PMID:36481612 PubMed Central PMC9731962.
  10. Reyna, MA, Haan, D, Paczkowska, M, Verbeke, LPC, Vazquez, M, Kahraman, A et al.. Author Correction: Pathway and network analysis of more than 2500 whole cancer genomes. Nat Commun. 2022;13 (1):7566. doi: 10.1038/s41467-022-32334-9. PubMed PMID:36481610 PubMed Central PMC9732045.
  11. Buhigas, C, Warren, AY, Leung, WK, Whitaker, HC, Luxton, HJ, Hawkins, S et al.. The architecture of clonal expansions in morphologically normal tissue from cancerous and non-cancerous prostates. Mol Cancer. 2022;21 (1):183. doi: 10.1186/s12943-022-01644-3. PubMed PMID:36131292 PubMed Central PMC9494848.
  12. Ouellet, V, Erickson, A, GAP1 UTMAs Contributing Investigators, Wiley, K, Morrissey, C, Berge, V et al.. The Movember Global Action Plan 1 (GAP1): Unique Prostate Cancer Tissue Microarray Resource. Cancer Epidemiol Biomarkers Prev. 2022;31 (4):715-727. doi: 10.1158/1055-9965.EPI-21-0600. PubMed PMID:35131885 PubMed Central PMC9381093.

Search PubMed

  1. Li, QK, Chen, J, Hu, Y, Höti, N, Lih, TM, Thomas, SN et al.. Proteomic characterization of primary and metastatic prostate cancer reveals reduced proteinase activity in aggressive tumors. Sci Rep. 2021;11 (1):18936. doi: 10.1038/s41598-021-98410-0. PubMed PMID:34556748 PubMed Central PMC8460832.
  2. Ketola, K, Kaljunen, H, Taavitsainen, S, Kaarijärvi, R, Järvelä, E, Rodríguez-Martín, B et al.. Subclone Eradication Analysis Identifies Targets for Enhanced Cancer Therapy and Reveals L1 Retrotransposition as a Dynamic Source of Cancer Heterogeneity. Cancer Res. 2021;81 (19):4901-4909. doi: 10.1158/0008-5472.CAN-21-0371. PubMed PMID:34348967 PubMed Central PMC9397610.
  3. Jasu, J, Tolonen, T, Antonarakis, ES, Beltran, H, Halabi, S, Eisenberger, MA et al.. Combined Longitudinal Clinical and Autopsy Phenomic Assessment in Lethal Metastatic Prostate Cancer: Recommendations for Advancing Precision Medicine. Eur Urol Open Sci. 2021;30 :47-62. doi: 10.1016/j.euros.2021.05.011. PubMed PMID:34337548 PubMed Central PMC8317817.
  4. Valkonen, M, Hognas, G, Bova, GS, Ruusuvuori, P. Generalized Fixation Invariant Nuclei Detection Through Domain Adaptation Based Deep Learning. IEEE J Biomed Health Inform. 2021;25 (5):1747-1757. doi: 10.1109/JBHI.2020.3039414. PubMed PMID:33211668 .

Search PubMed

  1. Bailey, MH, Meyerson, WU, Dursi, LJ, Wang, LB, Dong, G, Liang, WW et al.. Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples. Nat Commun. 2020;11 (1):6232. doi: 10.1038/s41467-020-20128-w. PubMed PMID:33257764 PubMed Central PMC7705717.
  2. Woodcock, DJ, Riabchenko, E, Taavitsainen, S, Kankainen, M, Gundem, G, Brewer, DS et al.. Prostate cancer evolution from multilineage primary to single lineage metastases with implications for liquid biopsy. Nat Commun. 2020;11 (1):5070. doi: 10.1038/s41467-020-18843-5. PubMed PMID:33033260 PubMed Central PMC7545111.
  3. Bailey, MH, Meyerson, WU, Dursi, LJ, Wang, LB, Dong, G, Liang, WW et al.. Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples. Nat Commun. 2020;11 (1):4748. doi: 10.1038/s41467-020-18151-y. PubMed PMID:32958763 PubMed Central PMC7505971.
  4. Li, CH, Prokopec, SD, Sun, RX, Yousif, F, Schmitz, N, PCAWG Tumour Subtypes and Clinical Translation et al.. Sex differences in oncogenic mutational processes. Nat Commun. 2020;11 (1):4330. doi: 10.1038/s41467-020-17359-2. PubMed PMID:32859912 PubMed Central PMC7455744.
  5. Gundem, G, Van Loo, P, Kremeyer, B, Alexandrov, LB, Tubio, JMC, Papaemmanuil, E et al.. Author Correction: The evolutionary history of lethal metastatic prostate cancer. Nature. 2020;584 (7820):E18. doi: 10.1038/s41586-020-2581-5. PubMed PMID:32728210 .
  6. PCAWG Transcriptome Core Group, Calabrese, C, Davidson, NR, Demircioğlu, D, Fonseca, NA, He, Y et al.. Genomic basis for RNA alterations in cancer. Nature. 2020;578 (7793):129-136. doi: 10.1038/s41586-020-1970-0. PubMed PMID:32025019 PubMed Central PMC7054216.
  7. Alexandrov, LB, Kim, J, Haradhvala, NJ, Huang, MN, Tian Ng, AW, Wu, Y et al.. The repertoire of mutational signatures in human cancer. Nature. 2020;578 (7793):94-101. doi: 10.1038/s41586-020-1943-3. PubMed PMID:32025018 PubMed Central PMC7054213.
  8. Rheinbay, E, Nielsen, MM, Abascal, F, Wala, JA, Shapira, O, Tiao, G et al.. Analyses of non-coding somatic drivers in 2,658 cancer whole genomes. Nature. 2020;578 (7793):102-111. doi: 10.1038/s41586-020-1965-x. PubMed PMID:32025015 PubMed Central PMC7054214.
  9. Gerstung, M, Jolly, C, Leshchiner, I, Dentro, SC, Gonzalez, S, Rosebrock, D et al.. The evolutionary history of 2,658 cancers. Nature. 2020;578 (7793):122-128. doi: 10.1038/s41586-019-1907-7. PubMed PMID:32025013 PubMed Central PMC7054212.
  10. Li, Y, Roberts, ND, Wala, JA, Shapira, O, Schumacher, SE, Kumar, K et al.. Patterns of somatic structural variation in human cancer genomes. Nature. 2020;578 (7793):112-121. doi: 10.1038/s41586-019-1913-9. PubMed PMID:32025012 PubMed Central PMC7025897.
  11. ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium. Pan-cancer analysis of whole genomes. Nature. 2020;578 (7793):82-93. doi: 10.1038/s41586-020-1969-6. PubMed PMID:32025007 PubMed Central PMC7025898.
  12. Cortés-Ciriano, I, Lee, JJ, Xi, R, Jain, D, Jung, YL, Yang, L et al.. Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing. Nat Genet. 2020;52 (3):331-341. doi: 10.1038/s41588-019-0576-7. PubMed PMID:32025003 PubMed Central PMC7058534.
  13. Zapatka, M, Borozan, I, Brewer, DS, Iskar, M, Grundhoff, A, Alawi, M et al.. The landscape of viral associations in human cancers. Nat Genet. 2020;52 (3):320-330. doi: 10.1038/s41588-019-0558-9. PubMed PMID:32025001 PubMed Central PMC8076016.
  14. Akdemir, KC, Le, VT, Chandran, S, Li, Y, Verhaak, RG, Beroukhim, R et al.. Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer. Nat Genet. 2020;52 (3):294-305. doi: 10.1038/s41588-019-0564-y. PubMed PMID:32024999 PubMed Central PMC7058537.
  15. Rodriguez-Martin, B, Alvarez, EG, Baez-Ortega, A, Zamora, J, Supek, F, Demeulemeester, J et al.. Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition. Nat Genet. 2020;52 (3):306-319. doi: 10.1038/s41588-019-0562-0. PubMed PMID:32024998 PubMed Central PMC7058536.
  16. Yuan, Y, Ju, YS, Kim, Y, Li, J, Wang, Y, Yoon, CJ et al.. Comprehensive molecular characterization of mitochondrial genomes in human cancers. Nat Genet. 2020;52 (3):342-352. doi: 10.1038/s41588-019-0557-x. PubMed PMID:32024997 PubMed Central PMC7058535.
  17. Carlevaro-Fita, J, Lanzós, A, Feuerbach, L, Hong, C, Mas-Ponte, D, Pedersen, JS et al.. Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis. Commun Biol. 2020;3 (1):56. doi: 10.1038/s42003-019-0741-7. PubMed PMID:32024996 PubMed Central PMC7002399.
  18. Yakneen, S, Waszak, SM, PCAWG Technical Working Group, Gertz, M, Korbel, JO, PCAWG Consortium et al.. Butler enables rapid cloud-based analysis of thousands of human genomes. Nat Biotechnol. 2020;38 (3):288-292. doi: 10.1038/s41587-019-0360-3. PubMed PMID:32024987 PubMed Central PMC7062635.
  19. Reyna, MA, Haan, D, Paczkowska, M, Verbeke, LPC, Vazquez, M, Kahraman, A et al.. Pathway and network analysis of more than 2500 whole cancer genomes. Nat Commun. 2020;11 (1):729. doi: 10.1038/s41467-020-14367-0. PubMed PMID:32024854 PubMed Central PMC7002574.
  20. Jiao, W, Atwal, G, Polak, P, Karlic, R, Cuppen, E, PCAWG Tumor Subtypes and Clinical Translation Working Group et al.. A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns. Nat Commun. 2020;11 (1):728. doi: 10.1038/s41467-019-13825-8. PubMed PMID:32024849 PubMed Central PMC7002586.
  21. Paczkowska, M, Barenboim, J, Sintupisut, N, Fox, NS, Zhu, H, Abd-Rabbo, D et al.. Integrative pathway enrichment analysis of multivariate omics data. Nat Commun. 2020;11 (1):735. doi: 10.1038/s41467-019-13983-9. PubMed PMID:32024846 PubMed Central PMC7002665.
  22. Cmero, M, Yuan, K, Ong, CS, Schröder, J, PCAWG Evolution and Heterogeneity Working Group, Corcoran, NM et al.. Inferring structural variant cancer cell fraction. Nat Commun. 2020;11 (1):730. doi: 10.1038/s41467-020-14351-8. PubMed PMID:32024845 PubMed Central PMC7002525.
  23. Rubanova, Y, Shi, R, Harrigan, CF, Li, R, Wintersinger, J, Sahin, N et al.. Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig. Nat Commun. 2020;11 (1):731. doi: 10.1038/s41467-020-14352-7. PubMed PMID:32024834 PubMed Central PMC7002414.
  24. Zhang, Y, Chen, F, Fonseca, NA, He, Y, Fujita, M, Nakagawa, H et al.. High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations. Nat Commun. 2020;11 (1):736. doi: 10.1038/s41467-019-13885-w. PubMed PMID:32024823 PubMed Central PMC7002524.
  25. Bhandari, V, Li, CH, Bristow, RG, Boutros, PC, PCAWG Consortium. Divergent mutational processes distinguish hypoxic and normoxic tumours. Nat Commun. 2020;11 (1):737. doi: 10.1038/s41467-019-14052-x. PubMed PMID:32024819 PubMed Central PMC7002770.
  26. Shuai, S, PCAWG Drivers and Functional Interpretation Working Group, Gallinger, S, Stein, LD, PCAWG Consortium. Combined burden and functional impact tests for cancer driver discovery using DriverPower. Nat Commun. 2020;11 (1):734. doi: 10.1038/s41467-019-13929-1. PubMed PMID:32024818 PubMed Central PMC7002750.
  27. Sieverling, L, Hong, C, Koser, SD, Ginsbach, P, Kleinheinz, K, Hutter, B et al.. Genomic footprints of activated telomere maintenance mechanisms in cancer. Nat Commun. 2020;11 (1):733. doi: 10.1038/s41467-019-13824-9. PubMed PMID:32024817 PubMed Central PMC7002710.

Search PubMed

  1. Kallio, HML, Hieta, R, Latonen, L, Brofeldt, A, Annala, M, Kivinummi, K et al.. Constitutively active androgen receptor splice variants AR-V3, AR-V7 and AR-V9 are co-expressed in castration-resistant prostate cancer metastases. Br J Cancer. 2018;119 (3):347-356. doi: 10.1038/s41416-018-0172-0. PubMed PMID:29988112 PubMed Central PMC6070921.
  2. Sainio, M, Visakorpi, T, Tolonen, T, Ilvesaro, J, Bova, GS. Expression of neuroendocrine differentiation markers in lethal metastatic castration-resistant prostate cancer. Pathol Res Pract. 2018;214 (6):848-856. doi: 10.1016/j.prp.2018.04.015. PubMed PMID:29728311 .
  3. Wedge, DC, Gundem, G, Mitchell, T, Woodcock, DJ, Martincorena, I, Ghori, M et al.. Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets. Nat Genet. 2018;50 (5):682-692. doi: 10.1038/s41588-018-0086-z. PubMed PMID:29662167 PubMed Central PMC6372064.
  4. Högnäs, G, Kivinummi, K, Kallio, HML, Hieta, R, Ruusuvuori, P, Koskenalho, A et al.. Feasibility of Prostate PAXgene Fixation for Molecular Research and Diagnostic Surgical Pathology: Comparison of Matched Fresh Frozen, FFPE, and PFPE Tissues. Am J Surg Pathol. 2018;42 (1):103-115. doi: 10.1097/PAS.0000000000000961. PubMed PMID:28984675 .

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Jorma Isola – Cancer biology
2021-2024

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  1. Isola, J, Mäki, M, Hils, M, Pasternack, R, Viiri, K, Dotsenko, V et al.. The Oral Transglutaminase 2 Inhibitor ZED1227 Accumulates in the Villous Enterocytes in Celiac Disease Patients during Gluten Challenge and Drug Treatment. Int J Mol Sci. 2023;24 (13):. doi: 10.3390/ijms241310815. PubMed PMID:37445994 PubMed Central PMC10341493.
  2. Tye-Din, JA, Daveson, AJM, Goel, G, Goldstein, KE, Hand, HL, Neff, KM et al.. Efficacy and safety of gluten peptide-based antigen-specific immunotherapy (Nexvax2) in adults with coeliac disease after bolus exposure to gluten (RESET CeD): an interim analysis of a terminated randomised, double-blind, placebo-controlled phase 2 study. Lancet Gastroenterol Hepatol. 2023;8 (5):446-457. doi: 10.1016/S2468-1253(22)00428-9. PubMed PMID:36898393 .

Search PubMed

  1. Murray, JA, Syage, JA, Wu, TT, Dickason, MA, Ramos, AG, Van Dyke, C et al.. Latiglutenase Protects the Mucosa and Attenuates Symptom Severity in Patients With Celiac Disease Exposed to a Gluten Challenge. Gastroenterology. 2022;163 (6):1510-1521.e6. doi: 10.1053/j.gastro.2022.07.071. PubMed PMID:35931103 PubMed Central PMC9707643.
  2. Närvä, E, Taskinen, ME, Lilla, S, Isomursu, A, Pietilä, M, Weltner, J et al.. MASTL is enriched in cancerous and pluripotent stem cells and influences OCT1/OCT4 levels. iScience. 2022;25 (6):104459. doi: 10.1016/j.isci.2022.104459. PubMed PMID:35677646 PubMed Central PMC9167974.
  3. Puttonen, M, Isola, J, Ylinen, O, Böhling, T, Koljonen, V, Sihto, H et al.. UV-induced local immunosuppression in the tumour microenvironment of eccrine porocarcinoma and poroma. Sci Rep. 2022;12 (1):5529. doi: 10.1038/s41598-022-09490-5. PubMed PMID:35365704 PubMed Central PMC8976087.
  4. Bychkov, D, Joensuu, H, Nordling, S, Tiulpin, A, Kücükel, H, Lundin, M et al.. Outcome and Biomarker Supervised Deep Learning for Survival Prediction in Two Multicenter Breast Cancer Series. J Pathol Inform. 2022;13 :9. doi: 10.4103/jpi.jpi_29_21. PubMed PMID:35136676 PubMed Central PMC8794033.
  5. Andriulli, A, Bevilacqua, A, Palmieri, O, Latiano, A, Fontana, R, Gioffreda, D et al.. Healthy and pro-inflammatory gut ecology plays a crucial role in the digestion and tolerance of a novel Gluten Friendly™ bread in celiac subjects: a randomized, double blind, placebo control study. Food Funct. 2022;13 (3):1299-1315. doi: 10.1039/d1fo00490e. PubMed PMID:35029612 .

Search PubMed

  1. Taavela, J, Viiri, K, Välimäki, A, Sarin, J, Salonoja, K, Mäki, M et al.. Apolipoprotein A4 Defines the Villus-Crypt Border in Duodenal Specimens for Celiac Disease Morphometry. Front Immunol. 2021;12 :713854. doi: 10.3389/fimmu.2021.713854. PubMed PMID:34394117 PubMed Central PMC8358775.
  2. Schuppan, D, Mäki, M, Lundin, KEA, Isola, J, Friesing-Sosnik, T, Taavela, J et al.. A Randomized Trial of a Transglutaminase 2 Inhibitor for Celiac Disease. N Engl J Med. 2021;385 (1):35-45. doi: 10.1056/NEJMoa2032441. PubMed PMID:34192430 .
  3. Repo, M, Hannula, M, Taavela, J, Hyttinen, J, Isola, J, Hiltunen, P et al.. Iron Transporter Protein Expressions in Children with Celiac Disease. Nutrients. 2021;13 (3):. doi: 10.3390/nu13030776. PubMed PMID:33673530 PubMed Central PMC7997288.
  4. Bychkov, D, Linder, N, Tiulpin, A, Kücükel, H, Lundin, M, Nordling, S et al.. Deep learning identifies morphological features in breast cancer predictive of cancer ERBB2 status and trastuzumab treatment efficacy. Sci Rep. 2021;11 (1):4037. doi: 10.1038/s41598-021-83102-6. PubMed PMID:33597560 PubMed Central PMC7890057.
  5. Alanko, J, Tanner, M, Vanninen, R, Auvinen, A, Isola, J. Triple-negative and HER2-positive breast cancers found by mammography screening show excellent prognosis. Breast Cancer Res Treat. 2021;187 (1):267-274. doi: 10.1007/s10549-020-06060-z. PubMed PMID:33420595 PubMed Central PMC8062374.
  6. Popp, A, Taavela, J, Graziano, P, Parente, P, Covelli, C, Lamacchia, C et al.. Correction to: A New Intraepithelial γδ T-Lymphocyte Marker for Celiac Disease Classification in Formalin-Fixed Paraffin-Embedded (FFPE) Duodenal Biopsies. Dig Dis Sci. 2021;66 (12):4572. doi: 10.1007/s10620-020-06731-3. PubMed PMID:33236317 PubMed Central PMC8589807.
  7. Popp, A, Taavela, J, Graziano, P, Parente, P, Covelli, C, Lamacchia, C et al.. A New Intraepithelial γδ T-Lymphocyte Marker for Celiac Disease Classification in Formalin-Fixed Paraffin-Embedded (FFPE) Duodenal Biopsies. Dig Dis Sci. 2021;66 (10):3352-3358. doi: 10.1007/s10620-020-06680-x. PubMed PMID:33140183 PubMed Central PMC8449760.
  8. Dotsenko, V, Oittinen, M, Taavela, J, Popp, A, Peräaho, M, Staff, S et al.. Genome-Wide Transcriptomic Analysis of Intestinal Mucosa in Celiac Disease Patients on a Gluten-Free Diet and Postgluten Challenge. Cell Mol Gastroenterol Hepatol. 2021;11 (1):13-32. doi: 10.1016/j.jcmgh.2020.07.010. PubMed PMID:32745639 PubMed Central PMC7593586.

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Pirkko Kellokumpu-LehtinenRadiotherapy and Oncology
2018-2024

  1. Tolaney, SM, Guarneri, V, Seo, JH, Cruz, J, Abreu, MH, Takahashi, M et al.. Long-term patient-reported outcomes from monarchE: Abemaciclib plus endocrine therapy as adjuvant therapy for HR+, HER2-, node-positive, high-risk, early breast cancer. Eur J Cancer. 2024;199 :113555. doi: 10.1016/j.ejca.2024.113555. PubMed PMID:38244363 .
  2. Reinikainen, P, Lehtinen, I, Luukkaala, T, Kellokumpu-Lehtinen, PL. Safer and More Convenient Modern Curative Radiotherapy for Patients With Early Prostate Cancer. Anticancer Res. 2024;44 (1):139-150. doi: 10.21873/anticanres.16796. PubMed PMID:38159980 .

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  1. Lehtonen, M, Kellokumpu-Lehtinen, PL. The past and present of prostate cancer and its treatment and diagnostics: A historical review. SAGE Open Med. 2023;11 :20503121231216837. doi: 10.1177/20503121231216837. PubMed PMID:38050625 PubMed Central PMC10693792.
  2. Haapasalmi, S, Lehto, JT, Metsänoja, R, Kellokumpu-Lehtinen, PI, Piili, RP. End-of-life Decision-making Differs Between a Cancer and a Dementia Patient: Influences of the Physician’s Background Factors. Anticancer Res. 2023;43 (8):3631-3638. doi: 10.21873/anticanres.16543. PubMed PMID:37500170 .
  3. Moisander, M, Skyttä, T, Kivistö, S, Huhtala, H, Nikus, K, Virtanen, V et al.. Radiotherapy-induced diffuse myocardial fibrosis in early-stage breast cancer patients – multimodality imaging study with six-year follow-up. Radiat Oncol. 2023;18 (1):124. doi: 10.1186/s13014-023-02319-z. PubMed PMID:37496091 PubMed Central PMC10373367.
  4. Lehtomäki, K, Heervä, E, Kellokumpu-Lehtinen, PL, Mustonen, H, Salminen, T, Joensuu, H et al.. Transient Changes in Serum CEA, CA19-9, CRP, YKL-40, and IL-6 during Adjuvant Chemotherapy and Survival of Patients with Colorectal Cancer. Int J Mol Sci. 2023;24 (7):. doi: 10.3390/ijms24076753. PubMed PMID:37047727 PubMed Central PMC10094778.
  5. Gillessen, S, Bossi, A, Davis, ID, de Bono, J, Fizazi, K, James, ND et al.. Management of patients with advanced prostate cancer-metastatic and/or castration-resistant prostate cancer: Report of the Advanced Prostate Cancer Consensus Conference (APCCC) 2022. Eur J Cancer. 2023;185 :178-215. doi: 10.1016/j.ejca.2023.02.018. PubMed PMID:37003085 .
  6. Metsälä, O, Wahlström, G, Taimen, P, Kellokumpu-Lehtinen, PL, Schleutker, J. Transcripts of the Prostate Cancer-Associated Gene Are Retained in the Nuclei of Prostatic Epithelial Cells. Int J Mol Sci. 2023;24 (2):. doi: 10.3390/ijms24021052. PubMed PMID:36674564 PubMed Central PMC9865797.
  7. Gillessen, S, Bossi, A, Davis, ID, de Bono, J, Fizazi, K, James, ND et al.. Management of Patients with Advanced Prostate Cancer. Part I: Intermediate-/High-risk and Locally Advanced Disease, Biochemical Relapse, and Side Effects of Hormonal Treatment: Report of the Advanced Prostate Cancer Consensus Conference 2022. Eur Urol. 2023;83 (3):267-293. doi: 10.1016/j.eururo.2022.11.002. PubMed PMID:36494221 PubMed Central PMC7614721.
  8. Reinikainen, P, Lehtonen, M, Lehtinen, I, Luukkaala, T, Sintonen, H, Kellokumpu-Lehtinen, PL et al.. Health-related Quality of Life of Patients Treated With Different Fractionation Schedules for Early Prostate Cancer Compared to the Age-standardized General Male Population. Clin Genitourin Cancer. 2023;21 (1):146-154. doi: 10.1016/j.clgc.2022.07.013. PubMed PMID:36038484 .

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  1. Gillessen, S, Bossi, A, Davis, ID, de Bono, J, Fizazi, K, James, ND et al.. Management of Patients with Advanced Prostate Cancer. Part I: Intermediate-/High-risk and Locally Advanced Disease, Biochemical Relapse, and Side Effects of Hormonal Treatment: Report of the Advanced Prostate Cancer Consensus Conference 2022. Eur Urol. 2023;83 (3):267-293. doi: 10.1016/j.eururo.2022.11.002. PubMed PMID:36494221 PubMed Central PMC7614721.
  2. Reinikainen, P, Lehtonen, M, Lehtinen, I, Luukkaala, T, Sintonen, H, Kellokumpu-Lehtinen, PL et al.. Health-related Quality of Life of Patients Treated With Different Fractionation Schedules for Early Prostate Cancer Compared to the Age-standardized General Male Population. Clin Genitourin Cancer. 2023;21 (1):146-154. doi: 10.1016/j.clgc.2022.07.013. PubMed PMID:36038484 .
  3. Kokkonen, K, Kellokumpu-Lehtinen, PL, Kankaanpää, M, Nikander, R, Penttinen, HM, Utriainen, M et al.. Factors predicting long-term physical activity of breast cancer survivors. 5-year-follow-up of the BREX exercise intervention study. Acta Oncol. 2022;61 (10):1200-1208. doi: 10.1080/0284186X.2022.2103388. PubMed PMID:35881067 .
  4. Lehtonen, M, Sormunen, J, Luukkaala, T, Marttila, T, McDermott, R, Joensuu, T et al.. 2-weekly versus 3-weekly docetaxel for metastatic castration-resistant prostate cancer: complete quality of life results from the randomised, phase-III PROSTY trial. Acta Oncol. 2022;61 (8):963-971. doi: 10.1080/0284186X.2022.2098680. PubMed PMID:35847998 .
  5. Tuohinen, SS, Aula, H, Skyttä, T, Huhtala, H, Keski-Pukkila, K, Nikus, K et al.. A Higher Mean Heart Radiation Dose Induces Higher Frequency of Multiple Cardiac Changes. Anticancer Res. 2022;42 (5):2519-2529. doi: 10.21873/anticanres.15730. PubMed PMID:35489742 .
  6. Tuohinen, SS, Skytta, T, Huhtala, H, Virtanen, V, Kellokumpu-Lehtinen, PL, Raatikainen, P et al.. Dynamic Integrated Backscatter Detects Radiotherapy-induced Cardiac Changes Better than Strain Analysis – A Prospective Three-year Study. Anticancer Res. 2022;42 (5):2507-2517. doi: 10.21873/anticanres.15729. PubMed PMID:35489739 .
  7. Reinikainen, P, Kapanen, M, Luukkaala, T, Kellokumpu-Lehtinen, PL. Acute Side-effects of Different Radiotherapy Treatment Schedules in Early Prostate Cancer. Anticancer Res. 2022;42 (5):2553-2565. doi: 10.21873/anticanres.15733. PubMed PMID:35489724 .
  8. Lehtomäki, K, Stedt, HP, Osterlund, E, Muhonen, T, Soveri, LM, Halonen, P et al.. Health-Related Quality of Life in Metastatic Colorectal Cancer Patients Treated with Curative Resection and/or Local Ablative Therapy or Systemic Therapy in the Finnish RAXO-Study. Cancers (Basel). 2022;14 (7):. doi: 10.3390/cancers14071713. PubMed PMID:35406485 PubMed Central PMC8996978.
  9. Bychkov, D, Joensuu, H, Nordling, S, Tiulpin, A, Kücükel, H, Lundin, M et al.. Outcome and Biomarker Supervised Deep Learning for Survival Prediction in Two Multicenter Breast Cancer Series. J Pathol Inform. 2022;13 :9. doi: 10.4103/jpi.jpi_29_21. PubMed PMID:35136676 PubMed Central PMC8794033.
  10. Poikonen-Saksela, P, Kolokotroni, E, Vehmanen, L, Mattson, J, Stamatakos, G, Huovinen, R et al.. A graphical LASSO analysis of global quality of life, sub scales of the EORTC QLQ-C30 instrument and depression in early breast cancer. Sci Rep. 2022;12 (1):2112. doi: 10.1038/s41598-022-06138-2. PubMed PMID:35136160 PubMed Central PMC8826362.
  11. Joensuu, H, Kellokumpu-Lehtinen, PL, Huovinen, R, Jukkola, A, Tanner, M, Ahlgren, J et al.. Adjuvant Capecitabine for Early Breast Cancer: 15-Year Overall Survival Results From a Randomized Trial. J Clin Oncol. 2022;40 (10):1051-1058. doi: 10.1200/JCO.21.02054. PubMed PMID:35020465 PubMed Central PMC8966968.
  12. Loi, S, Salgado, R, Adams, S, Pruneri, G, Francis, PA, Lacroix-Triki, M et al.. Tumor infiltrating lymphocyte stratification of prognostic staging of early-stage triple negative breast cancer. NPJ Breast Cancer. 2022;8 (1):3. doi: 10.1038/s41523-021-00362-1. PubMed PMID:35017545 PubMed Central PMC8752727.
  13. Lehtonen, M, Sormunen, J, Hjälm-Eriksson, M, Thellenberg-Karlsson, C, Huttunen, T, Ginman, C et al.. Health-related Quality of Life in Intermediate- or High-risk Patients Treated With Radical External Radiotherapy and Adjuvant Docetaxel for Localized Prostate Cancer: A Randomized, Phase III SPCG-13 Study. Anticancer Res. 2022;42 (1):87-92. doi: 10.21873/anticanres.15460. PubMed PMID:34969712 .
  14. Bärlund, M, Takala, L, Tianen, L, Kellokumpu-Lehtinen, PL. Real-world Evidence of Implementing eHealth Enables Fluent Symptom-based Follow-up of a Growing Number of Patients with Breast Cancer with the Same Healthcare Resources. Clin Breast Cancer. 2022;22 (3):261-268. doi: 10.1016/j.clbc.2021.09.005. PubMed PMID:34657816 .

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  1. Bärlund, M, Takala, L, Tianen, L, Kellokumpu-Lehtinen, PL. Real-world Evidence of Implementing eHealth Enables Fluent Symptom-based Follow-up of a Growing Number of Patients with Breast Cancer with the Same Healthcare Resources. Clin Breast Cancer. 2022;22 (3):261-268. doi: 10.1016/j.clbc.2021.09.005. PubMed PMID:34657816 .
  2. Vähäaho, N, Hakamies-Blomqvist, L, Blomqvist, C, Kellokumpu-Lehtinen, PL, Huovinen, R, Saarto, T et al.. Sense of Coherence as Predictor of Quality of Life in Early Breast Cancer Patients. Anticancer Res. 2021;41 (10):5045-5052. doi: 10.21873/anticanres.15319. PubMed PMID:34593453 .
  3. Choueiri, TK, Tomczak, P, Park, SH, Venugopal, B, Ferguson, T, Chang, YH et al.. Adjuvant Pembrolizumab after Nephrectomy in Renal-Cell Carcinoma. N Engl J Med. 2021;385 (8):683-694. doi: 10.1056/NEJMoa2106391. PubMed PMID:34407342 .
  4. Tuohinen, SS, Skyttä, T, Huhtala, H, Poutanen, T, Virtanen, V, Kellokumpu-Lehtinen, PL et al.. 3-Year Follow-Up of Radiation-Associated Changes in Diastolic Function by Speckle Tracking Echocardiography. JACC CardioOncol. 2021;3 (2):277-289. doi: 10.1016/j.jaccao.2021.03.005. PubMed PMID:34396335 PubMed Central PMC8352342.
  5. Lehtomäki, K, Mustonen, H, Kellokumpu-Lehtinen, PL, Joensuu, H, Hermunen, K, Soveri, LM et al.. Lead Time and Prognostic Role of Serum CEA, CA19-9, IL-6, CRP, and YKL-40 after Adjuvant Chemotherapy in Colorectal Cancer. Cancers (Basel). 2021;13 (15):. doi: 10.3390/cancers13153892. PubMed PMID:34359796 PubMed Central PMC8345682.
  6. Jasu, J, Tolonen, T, Antonarakis, ES, Beltran, H, Halabi, S, Eisenberger, MA et al.. Combined Longitudinal Clinical and Autopsy Phenomic Assessment in Lethal Metastatic Prostate Cancer: Recommendations for Advancing Precision Medicine. Eur Urol Open Sci. 2021;30 :47-62. doi: 10.1016/j.euros.2021.05.011. PubMed PMID:34337548 PubMed Central PMC8317817.
  7. Haapasalmi, S, Piili, RP, Metsänoja, R, Kellokumpu-Lehtinen, PI, Lehto, JT. Physicians’ decreased tendency to choose palliative care for patients with advanced dementia between 1999 and 2015. BMC Palliat Care. 2021;20 (1):119. doi: 10.1186/s12904-021-00811-5. PubMed PMID:34311739 PubMed Central PMC8312352.
  8. Schmidt, M, Edlund, K, Hengstler, JG, Heimes, AS, Almstedt, K, Lebrecht, A et al.. Prognostic Impact of Immunoglobulin Kappa C in Early Breast Cancer. Cancers (Basel). 2021;13 (14):. doi: 10.3390/cancers13143626. PubMed PMID:34298839 PubMed Central PMC8304855.
  9. Roine, E, Sintonen, H, Kellokumpu-Lehtinen, PL, Penttinen, H, Utriainen, M, Vehmanen, L et al.. Long-term health-related quality of life of breast cancer survivors remains impaired compared to the age-matched general population especially in young women. Results from the prospective controlled BREX exercise study. Breast. 2021;59 :110-116. doi: 10.1016/j.breast.2021.06.012. PubMed PMID:34225091 PubMed Central PMC8264211.
  10. Aho, S, Vuoristo, MS, Raitanen, J, Mansikkamäki, K, Alanko, J, Vähä-Ypyä, H et al.. Higher number of steps and breaks during sedentary behaviour are associated with better lipid profiles. BMC Public Health. 2021;21 (1):629. doi: 10.1186/s12889-021-10656-5. PubMed PMID:33789632 PubMed Central PMC8010961.
  11. Bychkov, D, Linder, N, Tiulpin, A, Kücükel, H, Lundin, M, Nordling, S et al.. Deep learning identifies morphological features in breast cancer predictive of cancer ERBB2 status and trastuzumab treatment efficacy. Sci Rep. 2021;11 (1):4037. doi: 10.1038/s41598-021-83102-6. PubMed PMID:33597560 PubMed Central PMC7890057.
  12. Takala, L, Kuusinen, TE, Skyttä, T, Kellokumpu-Lehtinen, PL, Bärlund, M. Electronic Patient-reported Outcomes During Breast Cancer Adjuvant Radiotherapy. Clin Breast Cancer. 2021;21 (3):e252-e270. doi: 10.1016/j.clbc.2020.10.004. PubMed PMID:33229222 .
  13. Vehmanen, L, Sievänen, H, Kellokumpu-Lehtinen, P, Nikander, R, Huovinen, R, Ruohola, J et al.. Five-year follow-up results of aerobic and impact training on bone mineral density in early breast cancer patients. Osteoporos Int. 2021;32 (3):473-482. doi: 10.1007/s00198-020-05611-w. PubMed PMID:32886189 PubMed Central PMC7929955.

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  1. Kellokumpu-Lehtinen, PL, Marttila, T, Jekunen, A, Hervonen, P, Klintrup, K, Kataja, V et al.. Biweekly Cabazitaxel Is a Safe Treatment Option for Metastatic Castration-resistant Prostate Cancer (mCRPC) Patients After Docetaxel – A Final Analysis of the Prosty II Trial. Anticancer Res. 2020;40 (12):6915-6921. doi: 10.21873/anticanres.14715. PubMed PMID:33288585 .
  2. Takala, L, Kuusinen, TE, Skyttä, T, Kellokumpu-Lehtinen, PL, Bärlund, M. Electronic Patient-reported Outcomes During Breast Cancer Adjuvant Radiotherapy. Clin Breast Cancer. 2021;21 (3):e252-e270. doi: 10.1016/j.clbc.2020.10.004. PubMed PMID:33229222 .
  3. Kellokumpu-Lehtinen, PL, Hjälm-Eriksson, M, Thellenberg-Karlsson, C, Åström, L, Franzen, L, Fransson, AF et al.. Corrigendum re “Docetaxel Versus Surveillance After Radical Radiotherapy for Intermediate- or High-risk Prostate Cancer-Results from the Prospective, Randomised, Open-label Phase III SPCG-13 Trial” [Eur Urol 2019;76:823-30]. Eur Urol. 2020;78 (6):e241-e242. doi: 10.1016/j.eururo.2020.08.035. PubMed PMID:32893063 .
  4. Vehmanen, L, Sievänen, H, Kellokumpu-Lehtinen, P, Nikander, R, Huovinen, R, Ruohola, J et al.. Five-year follow-up results of aerobic and impact training on bone mineral density in early breast cancer patients. Osteoporos Int. 2021;32 (3):473-482. doi: 10.1007/s00198-020-05611-w. PubMed PMID:32886189 PubMed Central PMC7929955.
  5. Pollari, M, Pellinen, T, Karjalainen-Lindsberg, ML, Kellokumpu-Lehtinen, PL, Leivonen, SK, Leppä, S et al.. Adverse prognostic impact of regulatory T-cells in testicular diffuse large B-cell lymphoma. Eur J Haematol. 2020;105 (6):712-721. doi: 10.1111/ejh.13484. PubMed PMID:32632935 .
  6. Lehtonen, M, Heiskanen, L, Reinikainen, P, Kellokumpu-Lehtinen, PL. Both comorbidity and worse performance status are associated with poorer overall survival after external beam radiotherapy for prostate cancer. BMC Cancer. 2020;20 (1):324. doi: 10.1186/s12885-020-06812-6. PubMed PMID:32295542 PubMed Central PMC7160996.
  7. Swain, SM, Miles, D, Kim, SB, Im, YH, Im, SA, Semiglazov, V et al.. Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA): end-of-study results from a double-blind, randomised, placebo-controlled, phase 3 study. Lancet Oncol. 2020;21 (4):519-530. doi: 10.1016/S1470-2045(19)30863-0. PubMed PMID:32171426 .
  8. Roine, E, Sintonen, H, Kellokumpu-Lehtinen, PL, Penttinen, H, Utriainen, M, Vehmanen, L et al.. Health-related Quality of Life of Breast Cancer Survivors Attending an Exercise Intervention Study: A Five-year Follow-up. In Vivo. 2020;34 (2):667-674. doi: 10.21873/invivo.11821. PubMed PMID:32111767 PubMed Central PMC7157873.
  9. Sonnenblick, A, Salmon-Divon, M, Salgado, R, Dvash, E, Pondé, N, Zahavi, T et al.. Reactive stroma and trastuzumab resistance in HER2-positive early breast cancer. Int J Cancer. 2020;147 (1):266-276. doi: 10.1002/ijc.32859. PubMed PMID:31904863 .
  10. Aula, H, Skyttä, T, Tuohinen, S, Luukkaala, T, Hämäläinen, M, Virtanen, V et al.. ST2 levels increased and were associated with changes in left ventricular systolic function during a three-year follow-up after adjuvant radiotherapy for breast cancer. Breast. 2020;49 :183-186. doi: 10.1016/j.breast.2019.12.001. PubMed PMID:31862685 PubMed Central PMC7375584.

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  1. Aula, H, Skyttä, T, Tuohinen, S, Luukkaala, T, Hämäläinen, M, Virtanen, V et al.. ST2 levels increased and were associated with changes in left ventricular systolic function during a three-year follow-up after adjuvant radiotherapy for breast cancer. Breast. 2020;49 :183-186. doi: 10.1016/j.breast.2019.12.001. PubMed PMID:31862685 PubMed Central PMC7375584.
  2. Lehtomaki, KI, Lahtinen, LI, Rintanen, N, Kuopio, T, Kholova, I, Makela, R et al.. Clonal Evolution of MEK/MAPK Pathway Activating Mutations in a Metastatic Colorectal Cancer Case. Anticancer Res. 2019;39 (11):5867-5877. doi: 10.21873/anticanres.13791. PubMed PMID:31704811 .
  3. Vuorinen, RL, Paunu, N, Turpeenniemi-Hujanen, T, Reunamo, T, Jekunen, A, Kataja, V et al.. Sunitinib First-line Treatment in Metastatic Renal Cell Carcinoma: Costs and Effects. Anticancer Res. 2019;39 (10):5559-5564. doi: 10.21873/anticanres.13749. PubMed PMID:31570450 .
  4. Kaikkonen, E, Ettala, O, Nikulainen, I, Taimen, P, Lehtinen, I, Boström, PJ et al.. rs77559646 Is Associated With First-line Docetaxel Treatment Response in Metastatic Castration-resistant Prostate Cancer. Anticancer Res. 2019;39 (10):5353-5359. doi: 10.21873/anticanres.13728. PubMed PMID:31570429 .
  5. Aula, H, Skyttä, T, Tuohinen, S, Luukkaala, T, Hämäläinen, M, Virtanen, V et al.. Transforming growth factor beta 1 levels predict echocardiographic changes at three years after adjuvant radiotherapy for breast cancer. Radiat Oncol. 2019;14 (1):155. doi: 10.1186/s13014-019-1366-1. PubMed PMID:31470867 PubMed Central PMC6717329.
  6. Kellokumpu-Lehtinen, PL, Hjälm-Eriksson, M, Thellenberg-Karlsson, C, Åström, L, Franzen, L, Fransson, AS et al.. Docetaxel Versus Surveillance After Radical Radiotherapy for Intermediate- or High-risk Prostate Cancer-Results from the Prospective, Randomised, Open-label Phase III SPCG-13 Trial. Eur Urol. 2019;76 (6):823-830. doi: 10.1016/j.eururo.2019.08.010. PubMed PMID:31443961 .
  7. Piili, RP, Lehto, JT, Metsänoja, R, Hinkka, H, Kellokumpu-Lehtinen, PI. Has there been a change in the end-of-life decision-making over the past 16 years?. BMJ Support Palliat Care. 2019; :. doi: 10.1136/bmjspcare-2019-001802. PubMed PMID:31395612 .
  8. Hackman, G, Taari, K, Tammela, TL, Matikainen, M, Kouri, M, Joensuu, T et al.. Randomised Trial of Adjuvant Radiotherapy Following Radical Prostatectomy Versus Radical Prostatectomy Alone in Prostate Cancer Patients with Positive Margins or Extracapsular Extension. Eur Urol. 2019;76 (5):586-595. doi: 10.1016/j.eururo.2019.07.001. PubMed PMID:31375279 .
  9. Tuohinen, SS, Skytta, T, Huhtala, H, Virtanen, V, Kellokumpu-Lehtinen, PL, Raatikainen, P et al.. Left Ventricular Speckle Tracking Echocardiography Changes Among Early-stage Breast Cancer Patients Three Years After Radiotherapy. Anticancer Res. 2019;39 (8):4227-4236. doi: 10.21873/anticanres.13584. PubMed PMID:31366510 .
  10. Terävä, J, Tiainen, L, Lamminmäki, U, Kellokumpu-Lehtinen, PL, Pettersson, K, Gidwani, K et al.. Lectin nanoparticle assays for detecting breast cancer-associated glycovariants of cancer antigen 15-3 (CA15-3) in human plasma. PLoS One. 2019;14 (7):e0219480. doi: 10.1371/journal.pone.0219480. PubMed PMID:31344060 PubMed Central PMC6658058.
  11. Tiainen, L, Korhonen, EA, Leppänen, VM, Luukkaala, T, Hämäläinen, M, Tanner, M et al.. High baseline Tie1 level predicts poor survival in metastatic breast cancer. BMC Cancer. 2019;19 (1):732. doi: 10.1186/s12885-019-5959-8. PubMed PMID:31340773 PubMed Central PMC6657075.
  12. Auvray, M, Auclin, E, Barthelemy, P, Bono, P, Kellokumpu-Lehtinen, P, Gross-Goupil, M et al.. Erratum to ‘Second-line targeted therapies after nivolumab-ipilimumab failure in metastatic renal cell carcinoma’ [Eur J Cancer 108 (February 2019) 33-40]. Eur J Cancer. 2019;119 :200-201. doi: 10.1016/j.ejca.2019.04.012. PubMed PMID:31301937 .
  13. Wu, X, Reinikainen, P, Kapanen, M, Vierikko, T, Ryymin, P, Kellokumpu-Lehtinen, PL et al.. Monitoring radiotherapy induced tissue changes in localized prostate cancer by multi-parametric magnetic resonance imaging (MP-MRI). Diagn Interv Imaging. 2019;100 (11):699-708. doi: 10.1016/j.diii.2019.06.003. PubMed PMID:31257114 .
  14. Skyttä, T, Tuohinen, S, Luukkaala, T, Virtanen, V, Raatikainen, P, Kellokumpu-Lehtinen, PL et al.. Adjuvant radiotherapy-induced cardiac changes among patients with early breast cancer: a three-year follow-up study. Acta Oncol. 2019;58 (9):1250-1258. doi: 10.1080/0284186X.2019.1630751. PubMed PMID:31219359 .
  15. Mannisto, S, Vähämurto, P, Pollari, M, Clausen, MR, Jyrkkiö, S, Kellokumpu-Lehtinen, PL et al.. Intravenous but not intrathecal central nervous system-directed chemotherapy improves survival in patients with testicular diffuse large B-cell lymphoma. Eur J Cancer. 2019;115 :27-36. doi: 10.1016/j.ejca.2019.04.004. PubMed PMID:31082690 .
  16. Tiainen, L, Hämäläinen, M, Luukkaala, T, Tanner, M, Lahdenperä, O, Vihinen, P et al.. Low Plasma IL-8 Levels During Chemotherapy Are Predictive of Excellent Long-Term Survival in Metastatic Breast Cancer. Clin Breast Cancer. 2019;19 (4):e522-e533. doi: 10.1016/j.clbc.2019.03.006. PubMed PMID:31029558 .
  17. Alminoja, A, Piili, RP, Hinkka, H, Metsänoja, R, Hirvonen, O, Tyynelä-Korhonen, K et al.. Does Decision-making in End-of-life Care Differ Between Graduating Medical Students and Experienced Physicians?. In Vivo. 2019;33 (3):903-909. doi: 10.21873/invivo.11557. PubMed PMID:31028215 PubMed Central PMC6559926.
  18. Penttinen, H, Utriainen, M, Kellokumpu-Lehtinen, PL, Raitanen, J, Sievänen, H, Nikander, R et al.. Effectiveness of a 12-month Exercise Intervention on Physical Activity and Quality of Life of Breast Cancer Survivors; Five-year Results of the BREX-study. In Vivo. 2019;33 (3):881-888. doi: 10.21873/invivo.11554. PubMed PMID:31028212 PubMed Central PMC6559915.
  19. Loi, S, Drubay, D, Adams, S, Pruneri, G, Francis, PA, Lacroix-Triki, M et al.. Tumor-Infiltrating Lymphocytes and Prognosis: A Pooled Individual Patient Analysis of Early-Stage Triple-Negative Breast Cancers. J Clin Oncol. 2019;37 (7):559-569. doi: 10.1200/JCO.18.01010. PubMed PMID:30650045 PubMed Central PMC7010425.
  20. Auvray, M, Auclin, E, Barthelemy, P, Bono, P, Kellokumpu-Lehtinen, P, Gross-Goupil, M et al.. Second-line targeted therapies after nivolumab-ipilimumab failure in metastatic renal cell carcinoma. Eur J Cancer. 2019;108 :33-40. doi: 10.1016/j.ejca.2018.11.031. PubMed PMID:30616146 .
  21. Takala, L, Bärlund, M, Kellokumpu-Lehtinen, PL. Effective Antiemetic Therapy Is Important With Adjuvant Anthracycline-based Chemotherapy in Breast Cancer. Anticancer Res. 2019;39 (1):279-283. doi: 10.21873/anticanres.13108. PubMed PMID:30591469 .
  22. Lehto, US, Ojanen, M, Väkevä, A, Dyba, T, Aromaa, A, Kellokumpu-Lehtinen, P et al.. Early quality-of-life and psychological predictors of disease-free time and survival in localized prostate cancer. Qual Life Res. 2019;28 (3):677-686. doi: 10.1007/s11136-018-2069-z. PubMed PMID:30511254 PubMed Central PMC6394517.
  23. Leivonen, SK, Pollari, M, Brück, O, Pellinen, T, Autio, M, Karjalainen-Lindsberg, ML et al.. T-cell inflamed tumor microenvironment predicts favorable prognosis in primary testicular lymphoma. Haematologica. 2019;104 (2):338-346. doi: 10.3324/haematol.2018.200105. PubMed PMID:30237271 PubMed Central PMC6355505.

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Olli LohiHematology and oncology
2020-2024

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  1. Zapilko, V, Moisio, S, Parikka, M, Heinäniemi, M, Lohi, O. Generation of a Zebrafish Knock-In Model Recapitulating Childhood ETV6::RUNX1-Positive B-Cell Precursor Acute Lymphoblastic Leukemia. Cancers (Basel). 2023;15 (24):. doi: 10.3390/cancers15245821. PubMed PMID:38136366 PubMed Central PMC10871125.
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  1. Peterziel, H, Jamaladdin, N, ElHarouni, D, Gerloff, XF, Herter, S, Fiesel, P et al.. Drug sensitivity profiling of 3D tumor tissue cultures in the pediatric precision oncology program INFORM. NPJ Precis Oncol. 2022;6 (1):94. doi: 10.1038/s41698-022-00335-y. PubMed PMID:36575299 PubMed Central PMC9794727.
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  11. Ventelä, J, Nikkilä, A, Jukkola, A, Lohi, O. Incidence and outcomes of cancer in 16- to 17-year-old adolescents. Acta Paediatr. 2022;111 (2):442-444. doi: 10.1111/apa.16161. PubMed PMID:34689375 PubMed Central PMC9299452.

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  1. Abuhamed, J, Nikkilä, A, Lohi, O, Auvinen, A. Trends of computed tomography use among children in Finland. Eur J Radiol Open. 2020;7 :100290. doi: 10.1016/j.ejro.2020.100290. PubMed PMID:33335951 PubMed Central PMC7733003.
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  1. Karppinen, S, Lohi, O, Vihola, M. Prediction of leukocyte counts during paediatric acute lymphoblastic leukaemia maintenance therapy. Sci Rep. 2019;9 (1):18076. doi: 10.1038/s41598-019-54492-5. PubMed PMID:31792398 PubMed Central PMC6889389.
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Johanna MäenpääGynaecological oncology
2020-2024

  1. Pothuri, B, Han, S, Chase, DM, Heitz, F, Burger, RA, Gaba, L et al.. Health-related quality of life in patients with newly diagnosed advanced ovarian cancer treated with niraparib vs placebo: Results from the phase 3 randomized PRIMA/ENGOT-OV26/GOG-3012 trial. Gynecol Oncol. 2024;184 :168-177. doi: 10.1016/j.ygyno.2024.01.021. PubMed PMID:38325276 .

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Daniela UngureanuCancer Signalling
2020-2024

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  2. Onuțu, C, Ungureanu, D, Isopescu, DN, Vornicu, N, Spiridon, IA. Sourcing Limestone Masonry for the Restoration of Heritage Buildings: Frumoasa Monastery Case Study. Materials (Basel). 2022;15 (20):. doi: 10.3390/ma15207178. PubMed PMID:36295245 PubMed Central PMC9610073.
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Tapio Visakorpi (Teuvo Tammela) – Molecular Biology of Prostate Cancer
2020-2024

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  17. Siltari, A, Lönnerbro, R, Pang, K, Shiranov, K, Asiimwe, A, Evans-Axelsson, S et al.. How Well do Polygenic Risk Scores Identify Men at High Risk for Prostate Cancer? Systematic Review and Meta-Analysis. Clin Genitourin Cancer. 2023;21 (2):316.e1-316.e11. doi: 10.1016/j.clgc.2022.09.006. PubMed PMID:36243664 .

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  12. Nygård, LH, Talala, K, Taari, K, Tammela, TLJ, Auvinen, A, Murtola, TJ et al.. Antidiabetic drugs, glycemic control and risk of benign prostatic hyperplasia. Prostate. 2023;83 (3):246-258. doi: 10.1002/pros.24456. PubMed PMID:36325820 .
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