Publications

G Steven Bova – PELICAN Personalized Cancer Medicine
2020

  1. Gundem, G, Van Loo, P, Kremeyer, B, Alexandrov, LB, Tubio, JMC, Papaemmanuil, E et al.. Author Correction: The evolutionary history of lethal metastatic prostate cancer. Nature. 2020; :. doi: 10.1038/s41586-020-2581-5. PubMed PMID:32728210 .
  2. ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium. Pan-cancer analysis of whole genomes. Nature. 2020;578 (7793):82-93. doi: 10.1038/s41586-020-1969-6. PubMed PMID:32025007 PubMed Central PMC7025898.

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2018

  1. Kallio, HML, Hieta, R, Latonen, L, Brofeldt, A, Annala, M, Kivinummi, K et al.. Constitutively active androgen receptor splice variants AR-V3, AR-V7 and AR-V9 are co-expressed in castration-resistant prostate cancer metastases. Br. J. Cancer. 2018;119 (3):347-356. doi: 10.1038/s41416-018-0172-0. PubMed PMID:29988112 PubMed Central PMC6070921.
  2. Sainio, M, Visakorpi, T, Tolonen, T, Ilvesaro, J, Bova, GS. Expression of neuroendocrine differentiation markers in lethal metastatic castration-resistant prostate cancer. Pathol. Res. Pract. 2018;214 (6):848-856. doi: 10.1016/j.prp.2018.04.015. PubMed PMID:29728311 .
  3. Wedge, DC, Gundem, G, Mitchell, T, Woodcock, DJ, Martincorena, I, Ghori, M et al.. Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets. Nat. Genet. 2018;50 (5):682-692. doi: 10.1038/s41588-018-0086-z. PubMed PMID:29662167 PubMed Central PMC6372064.
  4. Högnäs, G, Kivinummi, K, Kallio, HML, Hieta, R, Ruusuvuori, P, Koskenalho, A et al.. Feasibility of Prostate PAXgene Fixation for Molecular Research and Diagnostic Surgical Pathology: Comparison of Matched Fresh Frozen, FFPE, and PFPE Tissues. Am. J. Surg. Pathol. 2018;42 (1):103-115. doi: 10.1097/PAS.0000000000000961. PubMed PMID:28984675 .

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Jorma Isola – Cancer biology
2020

  1. Dotsenko, V, Oittinen, M, Taavela, J, Popp, A, Peräaho, M, Staff, S et al.. Genome-wide transcriptomic analysis of intestinal mucosa in celiac disease patients on a gluten-free diet and post gluten challenge. Cell Mol Gastroenterol Hepatol. 2020; :. doi: 10.1016/j.jcmgh.2020.07.010. PubMed PMID:32745639 .
  2. Byrd, KB, Lorenz, AA, Anderson, JA, Wallace, CSA, Moore-O’Leary, KA, Isola, J et al.. Quantifying drought’s influence on moist soil seed vegetation in California’s Central Valley through remote sensing. Ecol Appl. 2020; :. doi: 10.1002/eap.2153. PubMed PMID:32348601 .
  3. Barok, M, Le Joncour, V, Martins, A, Isola, J, Salmikangas, M, Laakkonen, P et al.. ARX788, a novel anti-HER2 antibody-drug conjugate, shows anti-tumor effects in preclinical models of trastuzumab emtansine-resistant HER2-positive breast cancer and gastric cancer. Cancer Lett. 2020;473 :156-163. doi: 10.1016/j.canlet.2019.12.037. PubMed PMID:31904483 .
  4. Isola, JVV, Zanini, BM, Sidhom, S, Kopchick, JJ, Bartke, A, Masternak, MM et al.. 17α-Estradiol promotes ovarian aging in growth hormone receptor knockout mice, but not wild-type littermates. Exp. Gerontol. 2020;129 :110769. doi: 10.1016/j.exger.2019.110769. PubMed PMID:31698046 PubMed Central PMC6911620.
  5. Valkonen, M, Isola, J, Ylinen, O, Muhonen, V, Saxlin, A, Tolonen, T et al.. Cytokeratin-Supervised Deep Learning for Automatic Recognition of Epithelial Cells in Breast Cancers Stained for ER, PR, and Ki-67. IEEE Trans Med Imaging. 2020;39 (2):534-542. doi: 10.1109/TMI.2019.2933656. PubMed PMID:31398111 .
  6. Luhtala, S, Haapaniemi, T, Staff, S, Isola, J. Fluoro-Chromogenic Labelling for Detection of MCM2 to Assess Proliferation Activity in HER2-amplified Breast Carcinomas. Appl. Immunohistochem. Mol. Morphol. 2020;28 (3):175-186. doi: 10.1097/PAI.0000000000000716. PubMed PMID:30358612 .

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2019

  1. Taavela, J, Viiri, K, Popp, A, Oittinen, M, Dotsenko, V, Peräaho, M et al.. Histological, immunohistochemical and mRNA gene expression responses in coeliac disease patients challenged with gluten using PAXgene fixed paraffin-embedded duodenal biopsies. BMC Gastroenterol. 2019;19 (1):189. doi: 10.1186/s12876-019-1089-7. PubMed PMID:31730447 PubMed Central PMC6858741.
  2. Isola, JVV, Zanini, BM, Sidhom, S, Kopchick, JJ, Bartke, A, Masternak, MM et al.. 17α-Estradiol promotes ovarian aging in growth hormone receptor knockout mice, but not wild-type littermates. Exp. Gerontol. 2020;129 :110769. doi: 10.1016/j.exger.2019.110769. PubMed PMID:31698046 PubMed Central PMC6911620.
  3. Lähdeaho, ML, Scheinin, M, Vuotikka, P, Taavela, J, Popp, A, Laukkarinen, J et al.. Safety and efficacy of AMG 714 in adults with coeliac disease exposed to gluten challenge: a phase 2a, randomised, double-blind, placebo-controlled study. Lancet Gastroenterol Hepatol. 2019;4 (12):948-959. doi: 10.1016/S2468-1253(19)30264-X. PubMed PMID:31494096 .
  4. Valkonen, M, Isola, J, Ylinen, O, Muhonen, V, Saxlin, A, Tolonen, T et al.. Cytokeratin-Supervised Deep Learning for Automatic Recognition of Epithelial Cells in Breast Cancers Stained for ER, PR, and Ki-67. IEEE Trans Med Imaging. 2020;39 (2):534-542. doi: 10.1109/TMI.2019.2933656. PubMed PMID:31398111 .
  5. Le Joncour, V, Martins, A, Puhka, M, Isola, J, Salmikangas, M, Laakkonen, P et al.. A Novel Anti-HER2 Antibody-Drug Conjugate XMT-1522 for HER2-Positive Breast and Gastric Cancers Resistant to Trastuzumab Emtansine. Mol. Cancer Ther. 2019;18 (10):1721-1730. doi: 10.1158/1535-7163.MCT-19-0207. PubMed PMID:31292166 .
  6. Turkki, R, Byckhov, D, Lundin, M, Isola, J, Nordling, S, Kovanen, PE et al.. Breast cancer outcome prediction with tumour tissue images and machine learning. Breast Cancer Res. Treat. 2019;177 (1):41-52. doi: 10.1007/s10549-019-05281-1. PubMed PMID:31119567 PubMed Central PMC6647903.
  7. Isola, JVV, Velasco Acosta, DA, Bespalhok Jacometo, C, Rincón, JAA, Silveira, PAS, Corrêa, MN et al.. Intrafollicular paraoxonase 1 activity and the steroidogenic potential of the first post-partum dominant follicle in dairy cows. Reprod. Domest. Anim. 2019;54 (6):924-927. doi: 10.1111/rda.13442. PubMed PMID:31004539 .

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2018

  1. Luhtala, S, Staff, S, Kallioniemi, A, Tanner, M, Isola, J. Clinicopathological and prognostic correlations of HER3 expression and its degradation regulators, NEDD4-1 and NRDP1, in primary breast cancer. BMC Cancer. 2018;18 (1):1045. doi: 10.1186/s12885-018-4917-1. PubMed PMID:30367623 PubMed Central PMC6204010.
  2. Helin, H, Tolonen, T, Ylinen, O, Tolonen, P, Näpänkangas, J, Isola, J et al.. Optimized JPEG 2000 Compression for Efficient Storage of Histopathological Whole-Slide Images. J Pathol Inform. 2018;9 :20. doi: 10.4103/jpi.jpi_69_17. PubMed PMID:29910969 PubMed Central PMC5989536.
  3. Barok, M, Puhka, M, Vereb, G, Szollosi, J, Isola, J, Joensuu, H et al.. Cancer-derived exosomes from HER2-positive cancer cells carry trastuzumab-emtansine into cancer cells leading to growth inhibition and caspase activation. BMC Cancer. 2018;18 (1):504. doi: 10.1186/s12885-018-4418-2. PubMed PMID:29720111 PubMed Central PMC5930687.
  4. Schaffer-Smith, D, Swenson, JJ, Reiter, ME, Isola, JE. Quantifying shorebird habitat in managed wetlands by modeling shallow water depth dynamics. Ecol Appl. 2018;28 (6):1534-1545. doi: 10.1002/eap.1732. PubMed PMID:29694689 PubMed Central PMC6123259.
  5. Koivusalo, L, Kaipia, A, Kujala, P, Isola, J, Tolonen, TT. Digital image analysis of the tissue surface areas of site-designated and bilaterally pooled prostate biopsies. Histol. Histopathol. 2018;33 (4):399-405. doi: 10.14670/HH-11-940. PubMed PMID:29058306 .
  6. Luhtala, S, Staff, S, Barok, M, Tanner, M, Isola, J. Comparison of Antibodies for Immunohistochemistry-based Detection of HER3 in Breast Cancer. Appl. Immunohistochem. Mol. Morphol. 2018;26 (3):212-219. doi: 10.1097/PAI.0000000000000406. PubMed PMID:27389555 .

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Anne KallioniemiCancer Genomics
2020

  1. Kuittinen, T, Rovio, P, Luukkaala, T, Laurila, M, Grénman, S, Kallioniemi, A et al.. Paclitaxel, Carboplatin and 1,25-D3 Inhibit Proliferation of Ovarian Cancer Cells In Vitro. Anticancer Res. 2020;40 (6):3129-3138. doi: 10.21873/anticanres.14294. PubMed PMID:32487607 .

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2019

  1. Nurmi, A, Muranen, TA, Pelttari, LM, Kiiski, JI, Heikkinen, T, Lehto, S et al.. Recurrent moderate-risk mutations in Finnish breast and ovarian cancer patients. Int. J. Cancer. 2019;145 (10):2692-2700. doi: 10.1002/ijc.32309. PubMed PMID:30927251 PubMed Central PMC6767104.
  2. Vuorinen, EM, Rajala, NK, Ihalainen, TO, Kallioniemi, A. Correction to: Depletion of nuclear import protein karyopherin alpha 7 (KPNA7) induces mitotic defects and deformation of nuclei in cancer cells. BMC Cancer. 2019;19 (1):57. doi: 10.1186/s12885-018-5234-4. PubMed PMID:30642282 PubMed Central PMC6330744.

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2019

  1. Luhtala, S, Staff, S, Kallioniemi, A, Tanner, M, Isola, J. Clinicopathological and prognostic correlations of HER3 expression and its degradation regulators, NEDD4-1 and NRDP1, in primary breast cancer. BMC Cancer. 2018;18 (1):1045. doi: 10.1186/s12885-018-4917-1. PubMed PMID:30367623 PubMed Central PMC6204010.
  2. Abu Khamidakh, AE, Rodriguez-Martinez, A, Kaarniranta, K, Kallioniemi, A, Skottman, H, Hyttinen, J et al.. Wound healing of human embryonic stem cell-derived retinal pigment epithelial cells is affected by maturation stage. Biomed Eng Online. 2018;17 (1):102. doi: 10.1186/s12938-018-0535-z. PubMed PMID:30064430 PubMed Central PMC6069779.
  3. Vuorinen, EM, Rajala, NK, Ihalainen, TO, Kallioniemi, A. Depletion of nuclear import protein karyopherin alpha 7 (KPNA7) induces mitotic defects and deformation of nuclei in cancer cells. BMC Cancer. 2018;18 (1):325. doi: 10.1186/s12885-018-4261-5. PubMed PMID:29580221 PubMed Central PMC5870926.
  4. Ampuja, M, Kallioniemi, A. Transcription factors-Intricate players of the bone morphogenetic protein signaling pathway. Genes Chromosomes Cancer. 2018;57 (1):3-11. doi: 10.1002/gcc.22502. PubMed PMID:28857319 .

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Pirkko Kellokumpu-LehtinenRadiotherapy and Oncology
2020

  1. Pollari, M, Pellinen, T, Karjalainen-Lindsberg, ML, Kellokumpu-Lehtinen, PL, Leivonen, SK, Leppä, S et al.. Adverse prognostic impact of regulatory T-cells in testicular diffuse large B-cell lymphoma. Eur. J. Haematol. 2020; :. doi: 10.1111/ejh.13484. PubMed PMID:32632935 .
  2. Lehtonen, M, Heiskanen, L, Reinikainen, P, Kellokumpu-Lehtinen, PL. Both comorbidity and worse performance status are associated with poorer overall survival after external beam radiotherapy for prostate cancer. BMC Cancer. 2020;20 (1):324. doi: 10.1186/s12885-020-06812-6. PubMed PMID:32295542 PubMed Central PMC7160996.
  3. Swain, SM, Miles, D, Kim, SB, Im, YH, Im, SA, Semiglazov, V et al.. Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA): end-of-study results from a double-blind, randomised, placebo-controlled, phase 3 study. Lancet Oncol. 2020;21 (4):519-530. doi: 10.1016/S1470-2045(19)30863-0. PubMed PMID:32171426 .
  4. Roine, E, Sintonen, H, Kellokumpu-Lehtinen, PL, Penttinen, H, Utriainen, M, Vehmanen, L et al.. Health-related Quality of Life of Breast Cancer Survivors Attending an Exercise Intervention Study: A Five-year Follow-up. In Vivo. ;34 (2):667-674. doi: 10.21873/invivo.11821. PubMed PMID:32111767 PubMed Central PMC7157873.
  5. Sonnenblick, A, Salmon-Divon, M, Salgado, R, Dvash, E, Pondé, N, Zahavi, T et al.. Reactive stroma and trastuzumab resistance in HER2-positive early breast cancer. Int. J. Cancer. 2020;147 (1):266-276. doi: 10.1002/ijc.32859. PubMed PMID:31904863 .
  6. Aula, H, Skyttä, T, Tuohinen, S, Luukkaala, T, Hämäläinen, M, Virtanen, V et al.. ST2 levels increased and were associated with changes in left ventricular systolic function during a three-year follow-up after adjuvant radiotherapy for breast cancer. Breast. 2020;49 :183-186. doi: 10.1016/j.breast.2019.12.001. PubMed PMID:31862685 PubMed Central PMC7375584.

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2019

  1. Aula, H, Skyttä, T, Tuohinen, S, Luukkaala, T, Hämäläinen, M, Virtanen, V et al.. ST2 levels increased and were associated with changes in left ventricular systolic function during a three-year follow-up after adjuvant radiotherapy for breast cancer. Breast. 2020;49 :183-186. doi: 10.1016/j.breast.2019.12.001. PubMed PMID:31862685 PubMed Central PMC7375584.
  2. Lehtomaki, KI, Lahtinen, LI, Rintanen, N, Kuopio, T, Kholova, I, Makela, R et al.. Clonal Evolution of MEK/MAPK Pathway Activating Mutations in a Metastatic Colorectal Cancer Case. Anticancer Res. 2019;39 (11):5867-5877. doi: 10.21873/anticanres.13791. PubMed PMID:31704811 .
  3. Vuorinen, RL, Paunu, N, Turpeenniemi-Hujanen, T, Reunamo, T, Jekunen, A, Kataja, V et al.. Sunitinib First-line Treatment in Metastatic Renal Cell Carcinoma: Costs and Effects. Anticancer Res. 2019;39 (10):5559-5564. doi: 10.21873/anticanres.13749. PubMed PMID:31570450 .
  4. Kaikkonen, E, Ettala, O, Nikulainen, I, Taimen, P, Lehtinen, I, Boström, PJ et al.. ANO7 rs77559646 Is Associated With First-line Docetaxel Treatment Response in Metastatic Castration-resistant Prostate Cancer. Anticancer Res. 2019;39 (10):5353-5359. doi: 10.21873/anticanres.13728. PubMed PMID:31570429 .
  5. Aula, H, Skyttä, T, Tuohinen, S, Luukkaala, T, Hämäläinen, M, Virtanen, V et al.. Transforming growth factor beta 1 levels predict echocardiographic changes at three years after adjuvant radiotherapy for breast cancer. Radiat Oncol. 2019;14 (1):155. doi: 10.1186/s13014-019-1366-1. PubMed PMID:31470867 PubMed Central PMC6717329.
  6. Kellokumpu-Lehtinen, PL, Hjälm-Eriksson, M, Thellenberg-Karlsson, C, Åström, L, Franzen, L, Fransson, AS et al.. Docetaxel Versus Surveillance After Radical Radiotherapy for Intermediate- or High-risk Prostate Cancer-Results from the Prospective, Randomised, Open-label Phase III SPCG-13 Trial. Eur. Urol. 2019;76 (6):823-830. doi: 10.1016/j.eururo.2019.08.010. PubMed PMID:31443961 .
  7. Piili, RP, Lehto, JT, Metsänoja, R, Hinkka, H, Kellokumpu-Lehtinen, PI. Has there been a change in the end-of-life decision-making over the past 16 years?. BMJ Support Palliat Care. 2019; :. doi: 10.1136/bmjspcare-2019-001802. PubMed PMID:31395612 .
  8. Hackman, G, Taari, K, Tammela, TL, Matikainen, M, Kouri, M, Joensuu, T et al.. Randomised Trial of Adjuvant Radiotherapy Following Radical Prostatectomy Versus Radical Prostatectomy Alone in Prostate Cancer Patients with Positive Margins or Extracapsular Extension. Eur. Urol. 2019;76 (5):586-595. doi: 10.1016/j.eururo.2019.07.001. PubMed PMID:31375279 .
  9. Tuohinen, SS, Skytta, T, Huhtala, H, Virtanen, V, Kellokumpu-Lehtinen, PL, Raatikainen, P et al.. Left Ventricular Speckle Tracking Echocardiography Changes Among Early-stage Breast Cancer Patients Three Years After Radiotherapy. Anticancer Res. 2019;39 (8):4227-4236. doi: 10.21873/anticanres.13584. PubMed PMID:31366510 .
  10. Terävä, J, Tiainen, L, Lamminmäki, U, Kellokumpu-Lehtinen, PL, Pettersson, K, Gidwani, K et al.. Lectin nanoparticle assays for detecting breast cancer-associated glycovariants of cancer antigen 15-3 (CA15-3) in human plasma. PLoS ONE. 2019;14 (7):e0219480. doi: 10.1371/journal.pone.0219480. PubMed PMID:31344060 PubMed Central PMC6658058.
  11. Tiainen, L, Korhonen, EA, Leppänen, VM, Luukkaala, T, Hämäläinen, M, Tanner, M et al.. High baseline Tie1 level predicts poor survival in metastatic breast cancer. BMC Cancer. 2019;19 (1):732. doi: 10.1186/s12885-019-5959-8. PubMed PMID:31340773 PubMed Central PMC6657075.
  12. Auvray, M, Auclin, E, Barthelemy, P, Bono, P, Kellokumpu-Lehtinen, P, Gross-Goupil, M et al.. Erratum to ‘Second-line targeted therapies after nivolumab-ipilimumab failure in metastatic renal cell carcinoma’ [Eur J Cancer 108 (February 2019) 33-40]. Eur. J. Cancer. 2019;119 :200-201. doi: 10.1016/j.ejca.2019.04.012. PubMed PMID:31301937 .
  13. Wu, X, Reinikainen, P, Kapanen, M, Vierikko, T, Ryymin, P, Kellokumpu-Lehtinen, PL et al.. Monitoring radiotherapy induced tissue changes in localized prostate cancer by multi-parametric magnetic resonance imaging (MP-MRI). Diagn Interv Imaging. 2019;100 (11):699-708. doi: 10.1016/j.diii.2019.06.003. PubMed PMID:31257114 .
  14. Skyttä, T, Tuohinen, S, Luukkaala, T, Virtanen, V, Raatikainen, P, Kellokumpu-Lehtinen, PL et al.. Adjuvant radiotherapy-induced cardiac changes among patients with early breast cancer: a three-year follow-up study. Acta Oncol. 2019;58 (9):1250-1258. doi: 10.1080/0284186X.2019.1630751. PubMed PMID:31219359 .
  15. Mannisto, S, Vähämurto, P, Pollari, M, Clausen, MR, Jyrkkiö, S, Kellokumpu-Lehtinen, PL et al.. Intravenous but not intrathecal central nervous system-directed chemotherapy improves survival in patients with testicular diffuse large B-cell lymphoma. Eur. J. Cancer. 2019;115 :27-36. doi: 10.1016/j.ejca.2019.04.004. PubMed PMID:31082690 .
  16. Tiainen, L, Hämäläinen, M, Luukkaala, T, Tanner, M, Lahdenperä, O, Vihinen, P et al.. Low Plasma IL-8 Levels During Chemotherapy Are Predictive of Excellent Long-Term Survival in Metastatic Breast Cancer. Clin. Breast Cancer. 2019;19 (4):e522-e533. doi: 10.1016/j.clbc.2019.03.006. PubMed PMID:31029558 .
  17. Alminoja, A, Piili, RP, Hinkka, H, Metsänoja, R, Hirvonen, O, Tyynelä-Korhonen, K et al.. Does Decision-making in End-of-life Care Differ Between Graduating Medical Students and Experienced Physicians?. In Vivo. ;33 (3):903-909. doi: 10.21873/invivo.11557. PubMed PMID:31028215 PubMed Central PMC6559926.
  18. Penttinen, H, Utriainen, M, Kellokumpu-Lehtinen, PL, Raitanen, J, Sievänen, H, Nikander, R et al.. Effectiveness of a 12-month Exercise Intervention on Physical Activity and Quality of Life of Breast Cancer Survivors; Five-year Results of the BREX-study. In Vivo. ;33 (3):881-888. doi: 10.21873/invivo.11554. PubMed PMID:31028212 PubMed Central PMC6559915.
  19. Loi, S, Drubay, D, Adams, S, Pruneri, G, Francis, PA, Lacroix-Triki, M et al.. Tumor-Infiltrating Lymphocytes and Prognosis: A Pooled Individual Patient Analysis of Early-Stage Triple-Negative Breast Cancers. J. Clin. Oncol. 2019;37 (7):559-569. doi: 10.1200/JCO.18.01010. PubMed PMID:30650045 PubMed Central PMC7010425.
  20. Auvray, M, Auclin, E, Barthelemy, P, Bono, P, Kellokumpu-Lehtinen, P, Gross-Goupil, M et al.. Second-line targeted therapies after nivolumab-ipilimumab failure in metastatic renal cell carcinoma. Eur. J. Cancer. 2019;108 :33-40. doi: 10.1016/j.ejca.2018.11.031. PubMed PMID:30616146 .
  21. Takala, L, Bärlund, M, Kellokumpu-Lehtinen, PL. Effective Antiemetic Therapy Is Important With Adjuvant Anthracycline-based Chemotherapy in Breast Cancer. Anticancer Res. 2019;39 (1):279-283. doi: 10.21873/anticanres.13108. PubMed PMID:30591469 .
  22. Lehto, US, Ojanen, M, Väkevä, A, Dyba, T, Aromaa, A, Kellokumpu-Lehtinen, P et al.. Early quality-of-life and psychological predictors of disease-free time and survival in localized prostate cancer. Qual Life Res. 2019;28 (3):677-686. doi: 10.1007/s11136-018-2069-z. PubMed PMID:30511254 PubMed Central PMC6394517.
  23. Leivonen, SK, Pollari, M, Brück, O, Pellinen, T, Autio, M, Karjalainen-Lindsberg, ML et al.. T-cell inflamed tumor microenvironment predicts favorable prognosis in primary testicular lymphoma. Haematologica. 2019;104 (2):338-346. doi: 10.3324/haematol.2018.200105. PubMed PMID:30237271 PubMed Central PMC6355505.

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2018

  1. Lehto, US, Ojanen, M, Väkevä, A, Dyba, T, Aromaa, A, Kellokumpu-Lehtinen, P et al.. Early quality-of-life and psychological predictors of disease-free time and survival in localized prostate cancer. Qual Life Res. 2019;28 (3):677-686. doi: 10.1007/s11136-018-2069-z. PubMed PMID:30511254 PubMed Central PMC6394517.
  2. Aula, H, Skyttä, T, Tuohinen, S, Luukkaala, T, Hämäläinen, M, Virtanen, V et al.. Decreases in TGF-β1 and PDGF levels are associated with echocardiographic changes during adjuvant radiotherapy for breast cancer. Radiat Oncol. 2018;13 (1):201. doi: 10.1186/s13014-018-1150-7. PubMed PMID:30340644 PubMed Central PMC6194684.
  3. Wu, X, Reinikainen, P, Kapanen, M, Vierikko, T, Ryymin, P, Kellokumpu-Lehtinen, PL et al.. Dynamic Contrast-Enhanced Imaging as a Prognostic Tool in Early Diagnosis of Prostate Cancer: Correlation with PSA and Clinical Stage. Contrast Media Mol Imaging. 2018;2018 :3181258. doi: 10.1155/2018/3181258. PubMed PMID:30327584 PubMed Central PMC6169212.
  4. Leivonen, SK, Pollari, M, Brück, O, Pellinen, T, Autio, M, Karjalainen-Lindsberg, ML et al.. T-cell inflamed tumor microenvironment predicts favorable prognosis in primary testicular lymphoma. Haematologica. 2019;104 (2):338-346. doi: 10.3324/haematol.2018.200105. PubMed PMID:30237271 PubMed Central PMC6355505.
  5. Kaikkonen, E, Rantapero, T, Zhang, Q, Taimen, P, Laitinen, V, Kallajoki, M et al.. ANO7 is associated with aggressive prostate cancer. Int. J. Cancer. 2018;143 (10):2479-2487. doi: 10.1002/ijc.31746. PubMed PMID:30157291 PubMed Central PMC6589920.
  6. Pollari, M, Brück, O, Pellinen, T, Vähämurto, P, Karjalainen-Lindsberg, ML, Mannisto, S et al.. PD-L1+ tumor-associated macrophages and PD-1+ tumor-infiltrating lymphocytes predict survival in primary testicular lymphoma. Haematologica. 2018;103 (11):1908-1914. doi: 10.3324/haematol.2018.197194. PubMed PMID:30026337 PubMed Central PMC6278972.
  7. Piili, RP, Lehto, JT, Luukkaala, T, Hinkka, H, Kellokumpu-Lehtinen, PI. Does special education in palliative medicine make a difference in end-of-life decision-making?. BMC Palliat Care. 2018;17 (1):94. doi: 10.1186/s12904-018-0349-6. PubMed PMID:30021586 PubMed Central PMC6052558.
  8. Joensuu, H, Fraser, J, Wildiers, H, Huovinen, R, Auvinen, P, Utriainen, M et al.. Effect of Adjuvant Trastuzumab for a Duration of 9 Weeks vs 1 Year With Concomitant Chemotherapy for Early Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer: The SOLD Randomized Clinical Trial. JAMA Oncol. 2018;4 (9):1199-1206. doi: 10.1001/jamaoncol.2018.1380. PubMed PMID:29852043 PubMed Central PMC6143012.
  9. Piili, RP, Metsänoja, R, Hinkka, H, Kellokumpu-Lehtinen, PI, Lehto, JT. Changes in attitudes towards hastened death among Finnish physicians over the past sixteen years. BMC Med Ethics. 2018;19 (1):40. doi: 10.1186/s12910-018-0290-5. PubMed PMID:29843682 PubMed Central PMC5975714.
  10. Tuohinen, SS, Keski-Pukkila, K, Skyttä, T, Huhtala, H, Virtanen, V, Kellokumpu-Lehtinen, PL et al.. Radiotherapy-induced Early ECG Changes and Their Comparison with Echocardiography in Patients with Early-stage Breast Cancer. Anticancer Res. 2018;38 (4):2207-2215. doi: 10.21873/anticanres.12463. PubMed PMID:29599341 .
  11. Motzer, RJ, Tannir, NM, McDermott, DF, Arén Frontera, O, Melichar, B, Choueiri, TK et al.. Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma. N. Engl. J. Med. 2018;378 (14):1277-1290. doi: 10.1056/NEJMoa1712126. PubMed PMID:29562145 PubMed Central PMC5972549.
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Olli LohiHematology and oncology
2020

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2019

  1. Karppinen, S, Lohi, O, Vihola, M. Prediction of leukocyte counts during paediatric acute lymphoblastic leukaemia maintenance therapy. Sci Rep. 2019;9 (1):18076. doi: 10.1038/s41598-019-54492-5. PubMed PMID:31792398 PubMed Central PMC6889389.
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  7. Pölönen, P, Mehtonen, J, Lin, J, Liuksiala, T, Häyrynen, S, Teppo, S et al.. Hemap: An Interactive Online Resource for Characterizing Molecular Phenotypes across Hematologic Malignancies. Cancer Res. 2019;79 (10):2466-2479. doi: 10.1158/0008-5472.CAN-18-2970. PubMed PMID:30940663 .
  8. Wolthers, BO, Mogensen, PR, Frandsen, TL, Abrahamsson, J, Behrendtz, M, Heyman, M et al.. Insulin-dependent diabetes: A chronic complication to acute pancreatitis in childhood acute lymphoblastic leukemia. Pediatr Blood Cancer. 2019;66 (1):e27437. doi: 10.1002/pbc.27437. PubMed PMID:30216644 .
  9. Poukka, M, Lund-Aho, T, Raittinen, P, Nikkilä, A, Kivinen, K, Lundán, T et al.. Acute Lymphoblastic Leukemia With INPP5D-ABL1 Fusion Responds to Imatinib Treatment. J. Pediatr. Hematol. Oncol. 2019;41 (7):e481-e483. doi: 10.1097/MPH.0000000000001267. PubMed PMID:30045148 .

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2018

  1. Wolthers, BO, Mogensen, PR, Frandsen, TL, Abrahamsson, J, Behrendtz, M, Heyman, M et al.. Insulin-dependent diabetes: A chronic complication to acute pancreatitis in childhood acute lymphoblastic leukemia. Pediatr Blood Cancer. 2019;66 (1):e27437. doi: 10.1002/pbc.27437. PubMed PMID:30216644 .
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  3. Nikkilä, A, Kendall, G, Raitanen, J, Spycher, B, Lohi, O, Auvinen, A et al.. Effects of incomplete residential histories on studies of environmental exposure with application to childhood leukaemia and background radiation. Environ. Res. 2018;166 :466-472. doi: 10.1016/j.envres.2018.06.035. PubMed PMID:29945121 .
  4. Nordfors, K, Haapasalo, J, Afyounian, E, Tuominen, J, Annala, M, Häyrynen, S et al.. Erratum: Whole-exome sequencing identifies germline mutation in TP53 and ATRX in a child with genomically aberrant AT/RT and her mother with anaplastic astrocytoma. Cold Spring Harb Mol Case Stud. 2018;4 (3):. doi: 10.1101/mcs.a003129. PubMed PMID:29858379 PubMed Central PMC5983177.
  5. Nordfors, K, Haapasalo, J, Afyounian, E, Tuominen, J, Annala, M, Häyrynen, S et al.. Whole-exome sequencing identifies germline mutation in TP53 and ATRX in a child with genomically aberrant AT/RT and her mother with anaplastic astrocytoma. Cold Spring Harb Mol Case Stud. 2018;4 (2):. doi: 10.1101/mcs.a002246. PubMed PMID:29602769 PubMed Central PMC5880256.
  6. de Bock, CE, Demeyer, S, Degryse, S, Verbeke, D, Sweron, B, Gielen, O et al.. HOXA9 Cooperates with Activated JAK/STAT Signaling to Drive Leukemia Development. Cancer Discov. 2018;8 (5):616-631. doi: 10.1158/2159-8290.CD-17-0583. PubMed PMID:29496663 .
  7. Norberg, A, Rosén, A, Raaschou-Jensen, K, Kjeldsen, L, Moilanen, JS, Paulsson-Karlsson, Y et al.. Novel variants in Nordic patients referred for genetic testing of telomere-related disorders. Eur. J. Hum. Genet. 2018;26 (6):858-867. doi: 10.1038/s41431-018-0112-8. PubMed PMID:29483670 PubMed Central PMC5974393.

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Johanna MäenpääGynaecological oncology
2020

  1. Savolainen, K, Scaravilli, M, Ilvesmäki, A, Staff, S, Tolonen, T, Mäenpää, JU et al.. Expression of the miR-200 family in tumor tissue, plasma and urine of epithelial ovarian cancer patients in comparison to benign counterparts. BMC Res Notes. 2020;13 (1):311. doi: 10.1186/s13104-020-05155-6. PubMed PMID:32611374 PubMed Central PMC7329467.
  2. Kuittinen, T, Rovio, P, Luukkaala, T, Laurila, M, Grénman, S, Kallioniemi, A et al.. Paclitaxel, Carboplatin and 1,25-D3 Inhibit Proliferation of Ovarian Cancer Cells In Vitro. Anticancer Res. 2020;40 (6):3129-3138. doi: 10.21873/anticanres.14294. PubMed PMID:32487607 .
  3. Huttala, O, Staff, S, Heinonen, T, Mäenpää, J, Tanner, M, Ylikomi, T et al.. In Vitro Vascular Network Modified to Function as Culture Platform and Angiogenic Induction Potential Test for Cancer Cells. Int J Mol Sci. 2020;21 (5):. doi: 10.3390/ijms21051833. PubMed PMID:32155897 PubMed Central PMC7084873.
  4. Rohr, I, Alavi, S, Richter, R, Keller, M, Chekerov, R, Oskay-Özcelik, G et al.. Expectations and preferences of patients with primary and relapsed ovarian cancer to maintenance therapy: A NOGGO/ENGOT-ov22 and GCIG survey (Expression IV). Int. J. Gynecol. Cancer. 2020;30 (4):509-514. doi: 10.1136/ijgc-2019-000892. PubMed PMID:32139438 .
  5. Aalto, A, Huotari-Orava, R, Luhtala, S, Mäenpää, J, Staff, S. Expression of Estrogen-Related Receptors in Localized Provoked Vulvodynia. Biores Open Access. 2020;9 (1):13-21. doi: 10.1089/biores.2019.0049. PubMed PMID:32117596 PubMed Central PMC7047250.
  6. Kalamo, MH, Mäenpää, JU, Seppälä, TT, Mecklin, JP, Huhtala, H, Sorvettula, K et al.. Factors associated with decision-making on prophylactic hysterectomy and attitudes towards gynecological surveillance among women with Lynch syndrome (LS): a descriptive study. Fam. Cancer. 2020;19 (2):177-182. doi: 10.1007/s10689-020-00158-5. PubMed PMID:31997047 PubMed Central PMC7101284.
  7. Vuorinen, RK, Luukkaala, TH, Mäenpää, JU. The influence of bevacizumab on the costs of ovarian cancer treatment in routine clinical practice. Acta Oncol. 2020;59 (4):453-457. doi: 10.1080/0284186X.2019.1711175. PubMed PMID:31920123 .
  8. Antila, RM, Mäenpää, JU, Huhtala, HS, Tomás, EI, Staff, SM. Association of cesarean scar defect with abnormal uterine bleeding: The results of a prospective study. Eur. J. Obstet. Gynecol. Reprod. Biol. 2020;244 :134-140. doi: 10.1016/j.ejogrb.2019.11.021. PubMed PMID:31785470 .

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2019

  1. Ray-Coquard, I, Pautier, P, Pignata, S, Pérol, D, González-Martín, A, Berger, R et al.. Olaparib plus Bevacizumab as First-Line Maintenance in Ovarian Cancer. N. Engl. J. Med. 2019;381 (25):2416-2428. doi: 10.1056/NEJMoa1911361. PubMed PMID:31851799 .
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  5. Kares, S, Veijalainen, O, Kholová, I, Tirkkonen, M, Vuento, R, Huhtala, H et al.. HIGH-RISK HPV testing as the primary screening method in an organized regional screening program for cervical cancer: the value of HPV16 and HPV18 genotyping?. APMIS. 2019;127 (11):710-716. doi: 10.1111/apm.12990. PubMed PMID:31403733 .
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  7. Falconer, H, Palsdottir, K, Stalberg, K, Dahm-Kähler, P, Ottander, U, Lundin, ES et al.. Robot-assisted approach to cervical cancer (RACC): an international multi-center, open-label randomized controlled trial. Int. J. Gynecol. Cancer. 2019;29 (6):1072-1076. doi: 10.1136/ijgc-2019-000558. PubMed PMID:31203203 .
  8. Aalto, AP, Huhtala, H, Mäenpää, J, Staff, S. Combination of Treatments With or Without Surgery in Localized Provoked Vulvodynia: Outcomes After Three Years of Follow-Up. Biores Open Access. 2019;8 (1):25-31. doi: 10.1089/biores.2018.0044. PubMed PMID:30867980 PubMed Central PMC6415354.
  9. Bhatla, N, Berek, JS, Cuello Fredes, M, Denny, LA, Grenman, S, Karunaratne, K et al.. Revised FIGO staging for carcinoma of the cervix uteri. Int J Gynaecol Obstet. 2019;145 (1):129-135. doi: 10.1002/ijgo.12749. PubMed PMID:30656645 .
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2018

  1. Veijalainen, O, Kares, S, Kujala, P, Vuento, R, Osuala, V, Tirkkonen, M et al.. Implementation of HPV-based cervical cancer screening in an organised regional screening programme: 3 years of experience. Cytopathology. 2019;30 (2):150-156. doi: 10.1111/cyt.12652. PubMed PMID:30421573 .
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  3. Niemi, RJ, Roine, AN, Eräviita, E, Kumpulainen, PS, Mäenpää, JU, Oksala, N et al.. FAIMS analysis of urine gaseous headspace is capable of differentiating ovarian cancer. Gynecol. Oncol. 2018;151 (3):519-524. doi: 10.1016/j.ygyno.2018.09.016. PubMed PMID:30257785 .
  4. Antila-Långsjö, RM, Mäenpää, JU, Huhtala, HS, Tomás, EI, Staff, SM. Cesarean scar defect: a prospective study on risk factors. Am. J. Obstet. Gynecol. 2018;219 (5):458.e1-458.e8. doi: 10.1016/j.ajog.2018.09.004. PubMed PMID:30240650 .
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  6. Antila-Långsjö, R, Mäenpää, JU, Huhtala, H, Tomás, E, Staff, S. Comparison of transvaginal ultrasound and saline contrast sonohysterography in evaluation of cesarean scar defect: a prospective cohort study. Acta Obstet Gynecol Scand. 2018;97 (9):1130-1136. doi: 10.1111/aogs.13367. PubMed PMID:29754409 .
  7. Mäenpää, MM, Nieminen, K, Tomás, EI, Luukkaala, TH, Mäenpää, JU. Robotic-Assisted Infrarenal Para-aortic Lymphadenectomy in Gynecological Cancers: Technique and Surgical Outcomes. Int. J. Gynecol. Cancer. 2018;28 (5):951-958. doi: 10.1097/IGC.0000000000001249. PubMed PMID:29683877 .
  8. Palmér, R, Mäenpää, J, Jauhiainen, A, Larsson, B, Mo, J, Russell, M et al.. Dipeptidyl Peptidase 1 Inhibitor AZD7986 Induces a Sustained, Exposure-Dependent Reduction in Neutrophil Elastase Activity in Healthy Subjects. Clin. Pharmacol. Ther. 2018;104 (6):1155-1164. doi: 10.1002/cpt.1053. PubMed PMID:29484635 PubMed Central PMC6282495.

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Daniela UngureanuCancer Signalling
2020

  1. Sheetz, JB, Mathea, S, Karvonen, H, Malhotra, K, Chatterjee, D, Niininen, W et al.. Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases. Mol. Cell. 2020; :. doi: 10.1016/j.molcel.2020.06.018. PubMed PMID:32619402 .

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2019

  1. Karvonen, H, Barker, H, Kaleva, L, Niininen, W, Ungureanu, D. Molecular Mechanisms Associated with ROR1-Mediated Drug Resistance: Crosstalk with Hippo-YAP/TAZ and BMI-1 Pathways. Cells. 2019;8 (8):. doi: 10.3390/cells8080812. PubMed PMID:31382410 PubMed Central PMC6721603.
  2. Tudor, Ș, Minciună, C, Lăcătuş, M, Gavrilă, D, Manciu, S, Ungureanu, D et al.. Transanal Total Mesorectal Excision – A Case Report. Chirurgia (Bucur). ;114 (2):278-283. doi: 10.21614/chirurgia.114.2.278. PubMed PMID:31060661 .
  3. Karvonen, H, Perttilä, R, Niininen, W, Hautanen, V, Barker, H, Murumägi, A et al.. Wnt5a and ROR1 activate non-canonical Wnt signaling via RhoA in TCF3-PBX1 acute lymphoblastic leukemia and highlight new treatment strategies via Bcl-2 co-targeting. Oncogene. 2019;38 (17):3288-3300. doi: 10.1038/s41388-018-0670-9. PubMed PMID:30631148 .

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2018

  1. Veskimäe, K, Scaravilli, M, Niininen, W, Karvonen, H, Jaatinen, S, Nykter, M et al.. Expression Analysis of Platinum Sensitive and Resistant Epithelial Ovarian Cancer Patient Samples Reveals New Candidates for Targeted Therapies. Transl Oncol. 2018;11 (5):1160-1170. doi: 10.1016/j.tranon.2018.07.010. PubMed PMID:30056367 PubMed Central PMC6079561.
  2. Karvonen, H, Perttilä, R, Niininen, W, Barker, H, Ungureanu, D. Targeting Wnt signaling pseudokinases in hematological cancers. Eur. J. Haematol. 2018;101 (4):457-465. doi: 10.1111/ejh.13137. PubMed PMID:29989208 .
  3. Karvonen, H, Summala, K, Niininen, W, Barker, HR, Ungureanu, D. Interaction between ROR1 and MuSK activation complex in myogenic cells. FEBS Lett. 2018;592 (3):434-445. doi: 10.1002/1873-3468.12966. PubMed PMID:29292499 .

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Teuvo Tammela (previous Tapio Visakorpi) – Molecular Biology of Prostate Cancer
2020

  1. Gundem, G, Van Loo, P, Kremeyer, B, Alexandrov, LB, Tubio, JMC, Papaemmanuil, E et al.. Author Correction: The evolutionary history of lethal metastatic prostate cancer. Nature. 2020; :. doi: 10.1038/s41586-020-2581-5. PubMed PMID:32728210 .
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  3. Siltari, A, Murtola, TJ, Talala, K, Taari, K, Tammela, TLJ, Auvinen, A et al.. Antihypertensive drug use and prostate cancer-specific mortality in Finnish men. PLoS ONE. 2020;15 (6):e0234269. doi: 10.1371/journal.pone.0234269. PubMed PMID:32598349 PubMed Central PMC7323967.
  4. Kohvakka, A, Sattari, M, Shcherban, A, Annala, M, Urbanucci, A, Kesseli, J et al.. AR and ERG drive the expression of prostate cancer specific long noncoding RNAs. Oncogene. 2020;39 (30):5241-5251. doi: 10.1038/s41388-020-1365-6. PubMed PMID:32555329 .
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  6. Talala, K, Heinävaara, S, Taari, K, Tammela, TLJ, Kujala, P, Stenman, UH et al.. Long-term health-related quality of life among men with prostate cancer in the Finnish randomized study of screening for prostate cancer. Cancer Med. 2020; :. doi: 10.1002/cam4.3181. PubMed PMID:32500650 .
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2019

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2018

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