Publications

G Steven Bova – PELICAN Personalized Cancer Medicine

2020-2025

1. Gheybi, K, Soh, PXY, Jiang, J, Mbeki, TMN, Louw, M, Burns, D et al.. Pathogenic variants reveal candidate genes for prostate cancer germline testing for men of African ancestry. Nat Commun. 2025;16 (1):8799. doi: 10.1038/s41467-025-63865-6. PubMed PMID:41038821 PubMed Central PMC12491615.
2. Sattari, M, Rauhala, H, Latonen, L, Isaacs, WB, Nykter, M, Bova, GS et al.. Identification of protein-coding genes associated with metastatic prostate cancer. Endocr Relat Cancer. 2025;32 (7):. doi: 10.1530/ERC-25-0070. PubMed PMID:40525903 PubMed Central PMC12203752.
3. Esentürk, E, Sahli, A, Haberland, V, Ziuboniewicz, A, Wirth, C, Bova, GS et al.. Causes of evolutionary divergence in prostate cancer. ArXiv. 2025; :. . PubMed PMID:40166741 PubMed Central PMC11957227.

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1. Kiviaho, A, Eerola, SK, Kallio, HML, Andersen, MK, Hoikka, M, Tiihonen, AM et al.. Single cell and spatial transcriptomics highlight the interaction of club-like cells with immunosuppressive myeloid cells in prostate cancer. Nat Commun. 2024;15 (1):9949. doi: 10.1038/s41467-024-54364-1. PubMed PMID:39550375 PubMed Central PMC11569175.
2. Woodcock, DJ, Sahli, A, Teslo, R, Bhandari, V, Gruber, AJ, Ziubroniewicz, A et al.. Genomic evolution shapes prostate cancer disease type. Cell Genom. 2024;4 (3):100511. doi: 10.1016/j.xgen.2024.100511. PubMed PMID:38428419 PubMed Central PMC10943594.

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1. Kaljunen, H, Taavitsainen, S, Kaarijärvi, R, Takala, E, Paakinaho, V, Nykter, M et al.. Fanconi anemia pathway regulation by FANCI in prostate cancer. Front Oncol. 2023;13 :1260826. doi: 10.3389/fonc.2023.1260826. PubMed PMID:38023254 PubMed Central PMC10643534.
2. Nurminen, A, Jaatinen, S, Taavitsainen, S, Högnäs, G, Lesluyes, T, Ansari-Pour, N et al.. Cancer origin tracing and timing in two high-risk prostate cancers using multisample whole genome analysis: prospects for personalized medicine. Genome Med. 2023;15 (1):82. doi: 10.1186/s13073-023-01242-y. PubMed PMID:37828555 PubMed Central PMC10571458.
3. Sattari, M, Kohvakka, A, Moradi, E, Rauhala, H, Urhonen, H, Isaacs, WB et al.. Identification of long noncoding RNAs with aberrant expression in prostate cancer metastases. Endocr Relat Cancer. 2023;30 (8):. doi: 10.1530/ERC-22-0247. PubMed PMID:37140987 PubMed Central PMC10326635.
4. Yakneen, S, Waszak, SM, PCAWG Technical Working Group, Gertz, M, Korbel, JO, PCAWG Consortium et al.. Author Correction: Butler enables rapid cloud-based analysis of thousands of human genomes. Nat Biotechnol. 2023;41 (4):577. doi: 10.1038/s41587-022-01554-1. PubMed PMID:36944844 PubMed Central PMC10110458.
5. Rodriguez-Martin, B, Alvarez, EG, Baez-Ortega, A, Zamora, J, Supek, F, Demeulemeester, J et al.. Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition. Nat Genet. 2023;55 (6):1080. doi: 10.1038/s41588-023-01319-9. PubMed PMID:36944736 PubMed Central PMC10260396.
6. Akdemir, KC, Le, VT, Chandran, S, Li, Y, Verhaak, RG, Beroukhim, R et al.. Author Correction: Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer. Nat Genet. 2023;55 (6):1079. doi: 10.1038/s41588-023-01318-w. PubMed PMID:36944735 PubMed Central PMC10260394.
7. Zapatka, M, Borozan, I, Brewer, DS, Iskar, M, Grundhoff, A, Alawi, M et al.. Author Correction: The landscape of viral associations in human cancers. Nat Genet. 2023;55 (6):1077. doi: 10.1038/s41588-023-01316-y. PubMed PMID:36944734 PubMed Central PMC10260395.
8. Cortés-Ciriano, I, Lee, JJ, Xi, R, Jain, D, Jung, YL, Yang, L et al.. Author Correction: Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing. Nat Genet. 2023;55 (6):1076. doi: 10.1038/s41588-023-01315-z. PubMed PMID:36944733 PubMed Central PMC10260391.
9. Yuan, Y, Ju, YS, Kim, Y, Li, J, Wang, Y, Yoon, CJ et al.. Author Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers. Nat Genet. 2023;55 (6):1078. doi: 10.1038/s41588-023-01317-x. PubMed PMID:36944732 PubMed Central PMC10260393.
10. Alexandrov, LB, Kim, J, Haradhvala, NJ, Huang, MN, Tian Ng, AW, Wu, Y et al.. Author Correction: The repertoire of mutational signatures in human cancer. Nature. 2023;614 (7948):E41. doi: 10.1038/s41586-022-05600-5. PubMed PMID:36697836 PubMed Central PMC9931578.
11. Li, Y, Roberts, ND, Wala, JA, Shapira, O, Schumacher, SE, Kumar, K et al.. Author Correction: Patterns of somatic structural variation in human cancer genomes. Nature. 2023;614 (7948):E38. doi: 10.1038/s41586-022-05597-x. PubMed PMID:36697835 PubMed Central PMC9931568.
12. ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium. Author Correction: Pan-cancer analysis of whole genomes. Nature. 2023;614 (7948):E39. doi: 10.1038/s41586-022-05598-w. PubMed PMID:36697834 PubMed Central PMC9931570.
13. Gerstung, M, Jolly, C, Leshchiner, I, Dentro, SC, Gonzalez, S, Rosebrock, D et al.. Author Correction: The evolutionary history of 2,658 cancers. Nature. 2023;614 (7948):E42. doi: 10.1038/s41586-022-05601-4. PubMed PMID:36697833 PubMed Central PMC9931577.
14. Rheinbay, E, Nielsen, MM, Abascal, F, Wala, JA, Shapira, O, Tiao, G et al.. Author Correction: Analyses of non-coding somatic drivers in 2,658 cancer whole genomes. Nature. 2023;614 (7948):E40. doi: 10.1038/s41586-022-05599-9. PubMed PMID:36697832 PubMed Central PMC9931557.
15. PCAWG Transcriptome Core Group, Calabrese, C, Davidson, NR, Demircioğlu, D, Fonseca, NA, He, Y et al.. Author Correction: Genomic basis for RNA alterations in cancer. Nature. 2023;614 (7948):E37. doi: 10.1038/s41586-022-05596-y. PubMed PMID:36697831 PubMed Central PMC9931574.

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1. Carlevaro-Fita, J, Lanzós, A, Feuerbach, L, Hong, C, Mas-Ponte, D, Pedersen, JS et al.. Author Correction: Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis. Commun Biol. 2022;5 (1):1347. doi: 10.1038/s42003-022-03769-z. PubMed PMID:36482178 PubMed Central PMC9732278.
2. Rubanova, Y, Shi, R, Harrigan, CF, Li, R, Wintersinger, J, Sahin, N et al.. Author Correction: Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig. Nat Commun. 2022;13 (1):7567. doi: 10.1038/s41467-022-32336-7. PubMed PMID:36482170 PubMed Central PMC9731941.
3. Sieverling, L, Hong, C, Koser, SD, Ginsbach, P, Kleinheinz, K, Hutter, B et al.. Author Correction: Genomic footprints of activated telomere maintenance mechanisms in cancer. Nat Commun. 2022;13 (1):7574. doi: 10.1038/s41467-022-32328-7. PubMed PMID:36481818 PubMed Central PMC9731961.
4. Shuai, S, PCAWG Drivers and Functional Interpretation Working Group, Gallinger, S, Stein, LD, PCAWG Consortium. Author Correction: Combined burden and functional impact tests for cancer driver discovery using DriverPower. Nat Commun. 2022;13 (1):7571. doi: 10.1038/s41467-022-32343-8. PubMed PMID:36481739 PubMed Central PMC9732291.
5. Cmero, M, Yuan, K, Ong, CS, Schröder, J, PCAWG Evolution and Heterogeneity Working Group, Corcoran, NM et al.. Author Correction: Inferring structural variant cancer cell fraction. Nat Commun. 2022;13 (1):7568. doi: 10.1038/s41467-022-32338-5. PubMed PMID:36481724 PubMed Central PMC9732297.
6. Jiao, W, Atwal, G, Polak, P, Karlic, R, Cuppen, E, PCAWG Tumor Subtypes and Clinical Translation Working Group et al.. Author Correction: A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns. Nat Commun. 2022;13 (1):7573. doi: 10.1038/s41467-022-32329-6. PubMed PMID:36481665 PubMed Central PMC9732335.
7. Paczkowska, M, Barenboim, J, Sintupisut, N, Fox, NS, Zhu, H, Abd-Rabbo, D et al.. Author Correction: Integrative pathway enrichment analysis of multivariate omics data. Nat Commun. 2022;13 (1):7570. doi: 10.1038/s41467-022-32342-9. PubMed PMID:36481658 PubMed Central PMC9731958.
8. Zhang, Y, Chen, F, Fonseca, NA, He, Y, Fujita, M, Nakagawa, H et al.. Author Correction: High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations. Nat Commun. 2022;13 (1):7572. doi: 10.1038/s41467-022-32333-w. PubMed PMID:36481652 PubMed Central PMC9732340.
9. Bhandari, V, Li, CH, Bristow, RG, Boutros, PC, PCAWG Consortium. Author Correction: Divergent mutational processes distinguish hypoxic and normoxic tumours. Nat Commun. 2022;13 (1):7569. doi: 10.1038/s41467-022-32339-4. PubMed PMID:36481612 PubMed Central PMC9731962.
10. Reyna, MA, Haan, D, Paczkowska, M, Verbeke, LPC, Vazquez, M, Kahraman, A et al.. Author Correction: Pathway and network analysis of more than 2500 whole cancer genomes. Nat Commun. 2022;13 (1):7566. doi: 10.1038/s41467-022-32334-9. PubMed PMID:36481610 PubMed Central PMC9732045.
11. Buhigas, C, Warren, AY, Leung, WK, Whitaker, HC, Luxton, HJ, Hawkins, S et al.. The architecture of clonal expansions in morphologically normal tissue from cancerous and non-cancerous prostates. Mol Cancer. 2022;21 (1):183. doi: 10.1186/s12943-022-01644-3. PubMed PMID:36131292 PubMed Central PMC9494848.
12. Ouellet, V, Erickson, A, GAP1 UTMAs Contributing Investigators, Wiley, K, Morrissey, C, Berge, V et al.. The Movember Global Action Plan 1 (GAP1): Unique Prostate Cancer Tissue Microarray Resource. Cancer Epidemiol Biomarkers Prev. 2022;31 (4):715-727. doi: 10.1158/1055-9965.EPI-21-0600. PubMed PMID:35131885 PubMed Central PMC9381093.

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1. Li, QK, Chen, J, Hu, Y, Höti, N, Lih, TM, Thomas, SN et al.. Proteomic characterization of primary and metastatic prostate cancer reveals reduced proteinase activity in aggressive tumors. Sci Rep. 2021;11 (1):18936. doi: 10.1038/s41598-021-98410-0. PubMed PMID:34556748 PubMed Central PMC8460832.
2. Ketola, K, Kaljunen, H, Taavitsainen, S, Kaarijärvi, R, Järvelä, E, Rodríguez-Martín, B et al.. Subclone Eradication Analysis Identifies Targets for Enhanced Cancer Therapy and Reveals L1 Retrotransposition as a Dynamic Source of Cancer Heterogeneity. Cancer Res. 2021;81 (19):4901-4909. doi: 10.1158/0008-5472.CAN-21-0371. PubMed PMID:34348967 PubMed Central PMC9397610.
3. Jasu, J, Tolonen, T, Antonarakis, ES, Beltran, H, Halabi, S, Eisenberger, MA et al.. Combined Longitudinal Clinical and Autopsy Phenomic Assessment in Lethal Metastatic Prostate Cancer: Recommendations for Advancing Precision Medicine. Eur Urol Open Sci. 2021;30 :47-62. doi: 10.1016/j.euros.2021.05.011. PubMed PMID:34337548 PubMed Central PMC8317817.
4. Valkonen, M, Hognas, G, Bova, GS, Ruusuvuori, P. Generalized Fixation Invariant Nuclei Detection Through Domain Adaptation Based Deep Learning. IEEE J Biomed Health Inform. 2021;25 (5):1747-1757. doi: 10.1109/JBHI.2020.3039414. PubMed PMID:33211668 .

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1. Bailey, MH, Meyerson, WU, Dursi, LJ, Wang, LB, Dong, G, Liang, WW et al.. Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples. Nat Commun. 2020;11 (1):6232. doi: 10.1038/s41467-020-20128-w. PubMed PMID:33257764 PubMed Central PMC7705717.
2. Woodcock, DJ, Riabchenko, E, Taavitsainen, S, Kankainen, M, Gundem, G, Brewer, DS et al.. Prostate cancer evolution from multilineage primary to single lineage metastases with implications for liquid biopsy. Nat Commun. 2020;11 (1):5070. doi: 10.1038/s41467-020-18843-5. PubMed PMID:33033260 PubMed Central PMC7545111.
3. Bailey, MH, Meyerson, WU, Dursi, LJ, Wang, LB, Dong, G, Liang, WW et al.. Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples. Nat Commun. 2020;11 (1):4748. doi: 10.1038/s41467-020-18151-y. PubMed PMID:32958763 PubMed Central PMC7505971.
4. Li, CH, Prokopec, SD, Sun, RX, Yousif, F, Schmitz, N, PCAWG Tumour Subtypes and Clinical Translation et al.. Sex differences in oncogenic mutational processes. Nat Commun. 2020;11 (1):4330. doi: 10.1038/s41467-020-17359-2. PubMed PMID:32859912 PubMed Central PMC7455744.
5. Gundem, G, Van Loo, P, Kremeyer, B, Alexandrov, LB, Tubio, JMC, Papaemmanuil, E et al.. Author Correction: The evolutionary history of lethal metastatic prostate cancer. Nature. 2020;584 (7820):E18. doi: 10.1038/s41586-020-2581-5. PubMed PMID:32728210 .
6. PCAWG Transcriptome Core Group, Calabrese, C, Davidson, NR, Demircioğlu, D, Fonseca, NA, He, Y et al.. Genomic basis for RNA alterations in cancer. Nature. 2020;578 (7793):129-136. doi: 10.1038/s41586-020-1970-0. PubMed PMID:32025019 PubMed Central PMC7054216.
7. Alexandrov, LB, Kim, J, Haradhvala, NJ, Huang, MN, Tian Ng, AW, Wu, Y et al.. The repertoire of mutational signatures in human cancer. Nature. 2020;578 (7793):94-101. doi: 10.1038/s41586-020-1943-3. PubMed PMID:32025018 PubMed Central PMC7054213.
8. Rheinbay, E, Nielsen, MM, Abascal, F, Wala, JA, Shapira, O, Tiao, G et al.. Analyses of non-coding somatic drivers in 2,658 cancer whole genomes. Nature. 2020;578 (7793):102-111. doi: 10.1038/s41586-020-1965-x. PubMed PMID:32025015 PubMed Central PMC7054214.
9. Gerstung, M, Jolly, C, Leshchiner, I, Dentro, SC, Gonzalez, S, Rosebrock, D et al.. The evolutionary history of 2,658 cancers. Nature. 2020;578 (7793):122-128. doi: 10.1038/s41586-019-1907-7. PubMed PMID:32025013 PubMed Central PMC7054212.
10. Li, Y, Roberts, ND, Wala, JA, Shapira, O, Schumacher, SE, Kumar, K et al.. Patterns of somatic structural variation in human cancer genomes. Nature. 2020;578 (7793):112-121. doi: 10.1038/s41586-019-1913-9. PubMed PMID:32025012 PubMed Central PMC7025897.
11. ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium. Pan-cancer analysis of whole genomes. Nature. 2020;578 (7793):82-93. doi: 10.1038/s41586-020-1969-6. PubMed PMID:32025007 PubMed Central PMC7025898.
12. Cortés-Ciriano, I, Lee, JJ, Xi, R, Jain, D, Jung, YL, Yang, L et al.. Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing. Nat Genet. 2020;52 (3):331-341. doi: 10.1038/s41588-019-0576-7. PubMed PMID:32025003 PubMed Central PMC7058534.
13. Zapatka, M, Borozan, I, Brewer, DS, Iskar, M, Grundhoff, A, Alawi, M et al.. The landscape of viral associations in human cancers. Nat Genet. 2020;52 (3):320-330. doi: 10.1038/s41588-019-0558-9. PubMed PMID:32025001 PubMed Central PMC8076016.
14. Akdemir, KC, Le, VT, Chandran, S, Li, Y, Verhaak, RG, Beroukhim, R et al.. Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer. Nat Genet. 2020;52 (3):294-305. doi: 10.1038/s41588-019-0564-y. PubMed PMID:32024999 PubMed Central PMC7058537.
15. Rodriguez-Martin, B, Alvarez, EG, Baez-Ortega, A, Zamora, J, Supek, F, Demeulemeester, J et al.. Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition. Nat Genet. 2020;52 (3):306-319. doi: 10.1038/s41588-019-0562-0. PubMed PMID:32024998 PubMed Central PMC7058536.
16. Yuan, Y, Ju, YS, Kim, Y, Li, J, Wang, Y, Yoon, CJ et al.. Comprehensive molecular characterization of mitochondrial genomes in human cancers. Nat Genet. 2020;52 (3):342-352. doi: 10.1038/s41588-019-0557-x. PubMed PMID:32024997 PubMed Central PMC7058535.
17. Carlevaro-Fita, J, Lanzós, A, Feuerbach, L, Hong, C, Mas-Ponte, D, Pedersen, JS et al.. Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis. Commun Biol. 2020;3 (1):56. doi: 10.1038/s42003-019-0741-7. PubMed PMID:32024996 PubMed Central PMC7002399.
18. Yakneen, S, Waszak, SM, PCAWG Technical Working Group, Gertz, M, Korbel, JO, PCAWG Consortium et al.. Butler enables rapid cloud-based analysis of thousands of human genomes. Nat Biotechnol. 2020;38 (3):288-292. doi: 10.1038/s41587-019-0360-3. PubMed PMID:32024987 PubMed Central PMC7062635.
19. Reyna, MA, Haan, D, Paczkowska, M, Verbeke, LPC, Vazquez, M, Kahraman, A et al.. Pathway and network analysis of more than 2500 whole cancer genomes. Nat Commun. 2020;11 (1):729. doi: 10.1038/s41467-020-14367-0. PubMed PMID:32024854 PubMed Central PMC7002574.
20. Jiao, W, Atwal, G, Polak, P, Karlic, R, Cuppen, E, PCAWG Tumor Subtypes and Clinical Translation Working Group et al.. A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns. Nat Commun. 2020;11 (1):728. doi: 10.1038/s41467-019-13825-8. PubMed PMID:32024849 PubMed Central PMC7002586.
21. Paczkowska, M, Barenboim, J, Sintupisut, N, Fox, NS, Zhu, H, Abd-Rabbo, D et al.. Integrative pathway enrichment analysis of multivariate omics data. Nat Commun. 2020;11 (1):735. doi: 10.1038/s41467-019-13983-9. PubMed PMID:32024846 PubMed Central PMC7002665.
22. Cmero, M, Yuan, K, Ong, CS, Schröder, J, PCAWG Evolution and Heterogeneity Working Group, Corcoran, NM et al.. Inferring structural variant cancer cell fraction. Nat Commun. 2020;11 (1):730. doi: 10.1038/s41467-020-14351-8. PubMed PMID:32024845 PubMed Central PMC7002525.
23. Rubanova, Y, Shi, R, Harrigan, CF, Li, R, Wintersinger, J, Sahin, N et al.. Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig. Nat Commun. 2020;11 (1):731. doi: 10.1038/s41467-020-14352-7. PubMed PMID:32024834 PubMed Central PMC7002414.
24. Zhang, Y, Chen, F, Fonseca, NA, He, Y, Fujita, M, Nakagawa, H et al.. High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations. Nat Commun. 2020;11 (1):736. doi: 10.1038/s41467-019-13885-w. PubMed PMID:32024823 PubMed Central PMC7002524.
25. Bhandari, V, Li, CH, Bristow, RG, Boutros, PC, PCAWG Consortium. Divergent mutational processes distinguish hypoxic and normoxic tumours. Nat Commun. 2020;11 (1):737. doi: 10.1038/s41467-019-14052-x. PubMed PMID:32024819 PubMed Central PMC7002770.
26. Shuai, S, PCAWG Drivers and Functional Interpretation Working Group, Gallinger, S, Stein, LD, PCAWG Consortium. Combined burden and functional impact tests for cancer driver discovery using DriverPower. Nat Commun. 2020;11 (1):734. doi: 10.1038/s41467-019-13929-1. PubMed PMID:32024818 PubMed Central PMC7002750.
27. Sieverling, L, Hong, C, Koser, SD, Ginsbach, P, Kleinheinz, K, Hutter, B et al.. Genomic footprints of activated telomere maintenance mechanisms in cancer. Nat Commun. 2020;11 (1):733. doi: 10.1038/s41467-019-13824-9. PubMed PMID:32024817 PubMed Central PMC7002710.

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1. Kallio, HML, Hieta, R, Latonen, L, Brofeldt, A, Annala, M, Kivinummi, K et al.. Constitutively active androgen receptor splice variants AR-V3, AR-V7 and AR-V9 are co-expressed in castration-resistant prostate cancer metastases. Br J Cancer. 2018;119 (3):347-356. doi: 10.1038/s41416-018-0172-0. PubMed PMID:29988112 PubMed Central PMC6070921.
2. Sainio, M, Visakorpi, T, Tolonen, T, Ilvesaro, J, Bova, GS. Expression of neuroendocrine differentiation markers in lethal metastatic castration-resistant prostate cancer. Pathol Res Pract. 2018;214 (6):848-856. doi: 10.1016/j.prp.2018.04.015. PubMed PMID:29728311 .
3. Wedge, DC, Gundem, G, Mitchell, T, Woodcock, DJ, Martincorena, I, Ghori, M et al.. Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets. Nat Genet. 2018;50 (5):682-692. doi: 10.1038/s41588-018-0086-z. PubMed PMID:29662167 PubMed Central PMC6372064.
4. Högnäs, G, Kivinummi, K, Kallio, HML, Hieta, R, Ruusuvuori, P, Koskenalho, A et al.. Feasibility of Prostate PAXgene Fixation for Molecular Research and Diagnostic Surgical Pathology: Comparison of Matched Fresh Frozen, FFPE, and PFPE Tissues. Am J Surg Pathol. 2018;42 (1):103-115. doi: 10.1097/PAS.0000000000000961. PubMed PMID:28984675 .

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Jorma Isola – Cancer biology

2021-2025

1. Yazdi, N, Pourjamal, N, Katainen, R, Väänänen, J, Dai, J, Vähärautio, A et al.. Drug-tolerant persisting polyploid giant cancer cells mediate resistance to HER2-targeting antibody-drug conjugates. Cancer Lett. 2025;630 :217900. doi: 10.1016/j.canlet.2025.217900. PubMed PMID:40614854 .
2. Meriläinen, AS, Sihto, H, Isola, J, Koljonen, V. Clinicopathological comparison of eccrine poroma and porocarcinoma: Ki-67 index is not a decisive factor. PLoS One. 2025;20 (5):e0324975. doi: 10.1371/journal.pone.0324975. PubMed PMID:40445996 PubMed Central PMC12124553.
3. Pourjamal, N, Le Joncour, V, Vereb, G, Honkamaki, C, Isola, J, Leyton, JV et al.. Disitamab vedotin in preclinical models of HER2-positive breast and gastric cancers resistant to trastuzumab emtansine and trastuzumab deruxtecan. Transl Oncol. 2025;53 :102284. doi: 10.1016/j.tranon.2025.102284. PubMed PMID:39837059 PubMed Central PMC11788861.
4. Daveson, AJM, Stubbs, R, Polasek, TM, Isola, J, Anderson, R, Tye-Din, JA et al.. Safety, clinical activity, pharmacodynamics, and pharmacokinetics of IMU-856, a SIRT6 modulator, in coeliac disease: a first-in-human, randomised, double-blind, placebo-controlled, phase 1 trial. Lancet Gastroenterol Hepatol. 2025;10 (1):44-54. doi: 10.1016/S2468-1253(24)00248-6. PubMed PMID:39521016 .

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1. Daveson, AJM, Stubbs, R, Polasek, TM, Isola, J, Anderson, R, Tye-Din, JA et al.. Safety, clinical activity, pharmacodynamics, and pharmacokinetics of IMU-856, a SIRT6 modulator, in coeliac disease: a first-in-human, randomised, double-blind, placebo-controlled, phase 1 trial. Lancet Gastroenterol Hepatol. 2025;10 (1):44-54. doi: 10.1016/S2468-1253(24)00248-6. PubMed PMID:39521016 .
2. Dotsenko, V, Tewes, B, Hils, M, Pasternack, R, Isola, J, Taavela, J et al.. Transcriptomic analysis of intestine following administration of a transglutaminase 2 inhibitor to prevent gluten-induced intestinal damage in celiac disease. Nat Immunol. 2024;25 (7):1218-1230. doi: 10.1038/s41590-024-01867-0. PubMed PMID:38914866 PubMed Central PMC11224021.

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1. Isola, J, Mäki, M, Hils, M, Pasternack, R, Viiri, K, Dotsenko, V et al.. The Oral Transglutaminase 2 Inhibitor ZED1227 Accumulates in the Villous Enterocytes in Celiac Disease Patients during Gluten Challenge and Drug Treatment. Int J Mol Sci. 2023;24 (13):. doi: 10.3390/ijms241310815. PubMed PMID:37445994 PubMed Central PMC10341493.
2. Tye-Din, JA, Daveson, AJM, Goel, G, Goldstein, KE, Hand, HL, Neff, KM et al.. Efficacy and safety of gluten peptide-based antigen-specific immunotherapy (Nexvax2) in adults with coeliac disease after bolus exposure to gluten (RESET CeD): an interim analysis of a terminated randomised, double-blind, placebo-controlled phase 2 study. Lancet Gastroenterol Hepatol. 2023;8 (5):446-457. doi: 10.1016/S2468-1253(22)00428-9. PubMed PMID:36898393 .

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Pirkko Kellokumpu-Lehtinen – Radiotherapy and Oncology

2018-2025

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1. Kellokumpu-Lehtinen, PL, Marttila, T, Jekunen, A, Hervonen, P, Klintrup, K, Kataja, V et al.. Biweekly Cabazitaxel Is a Safe Treatment Option for Metastatic Castration-resistant Prostate Cancer (mCRPC) Patients After Docetaxel – A Final Analysis of the Prosty II Trial. Anticancer Res. 2020;40 (12):6915-6921. doi: 10.21873/anticanres.14715. PubMed PMID:33288585 .
2. Takala, L, Kuusinen, TE, Skyttä, T, Kellokumpu-Lehtinen, PL, Bärlund, M. Electronic Patient-reported Outcomes During Breast Cancer Adjuvant Radiotherapy. Clin Breast Cancer. 2021;21 (3):e252-e270. doi: 10.1016/j.clbc.2020.10.004. PubMed PMID:33229222 .
3. Kellokumpu-Lehtinen, PL, Hjälm-Eriksson, M, Thellenberg-Karlsson, C, Åström, L, Franzen, L, Fransson, AF et al.. Corrigendum re “Docetaxel Versus Surveillance After Radical Radiotherapy for Intermediate- or High-risk Prostate Cancer-Results from the Prospective, Randomised, Open-label Phase III SPCG-13 Trial” [Eur Urol 2019;76:823-30]. Eur Urol. 2020;78 (6):e241-e242. doi: 10.1016/j.eururo.2020.08.035. PubMed PMID:32893063 .
4. Vehmanen, L, Sievänen, H, Kellokumpu-Lehtinen, P, Nikander, R, Huovinen, R, Ruohola, J et al.. Five-year follow-up results of aerobic and impact training on bone mineral density in early breast cancer patients. Osteoporos Int. 2021;32 (3):473-482. doi: 10.1007/s00198-020-05611-w. PubMed PMID:32886189 PubMed Central PMC7929955.
5. Pollari, M, Pellinen, T, Karjalainen-Lindsberg, ML, Kellokumpu-Lehtinen, PL, Leivonen, SK, Leppä, S et al.. Adverse prognostic impact of regulatory T-cells in testicular diffuse large B-cell lymphoma. Eur J Haematol. 2020;105 (6):712-721. doi: 10.1111/ejh.13484. PubMed PMID:32632935 .
6. Lehtonen, M, Heiskanen, L, Reinikainen, P, Kellokumpu-Lehtinen, PL. Both comorbidity and worse performance status are associated with poorer overall survival after external beam radiotherapy for prostate cancer. BMC Cancer. 2020;20 (1):324. doi: 10.1186/s12885-020-06812-6. PubMed PMID:32295542 PubMed Central PMC7160996.
7. Swain, SM, Miles, D, Kim, SB, Im, YH, Im, SA, Semiglazov, V et al.. Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA): end-of-study results from a double-blind, randomised, placebo-controlled, phase 3 study. Lancet Oncol. 2020;21 (4):519-530. doi: 10.1016/S1470-2045(19)30863-0. PubMed PMID:32171426 .
8. Roine, E, Sintonen, H, Kellokumpu-Lehtinen, PL, Penttinen, H, Utriainen, M, Vehmanen, L et al.. Health-related Quality of Life of Breast Cancer Survivors Attending an Exercise Intervention Study: A Five-year Follow-up. In Vivo. 2020;34 (2):667-674. doi: 10.21873/invivo.11821. PubMed PMID:32111767 PubMed Central PMC7157873.
9. Sonnenblick, A, Salmon-Divon, M, Salgado, R, Dvash, E, Pondé, N, Zahavi, T et al.. Reactive stroma and trastuzumab resistance in HER2-positive early breast cancer. Int J Cancer. 2020;147 (1):266-276. doi: 10.1002/ijc.32859. PubMed PMID:31904863 .
10. Aula, H, Skyttä, T, Tuohinen, S, Luukkaala, T, Hämäläinen, M, Virtanen, V et al.. ST2 levels increased and were associated with changes in left ventricular systolic function during a three-year follow-up after adjuvant radiotherapy for breast cancer. Breast. 2020;49 :183-186. doi: 10.1016/j.breast.2019.12.001. PubMed PMID:31862685 PubMed Central PMC7375584.

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1. Lehto, US, Ojanen, M, Väkevä, A, Dyba, T, Aromaa, A, Kellokumpu-Lehtinen, P et al.. Early quality-of-life and psychological predictors of disease-free time and survival in localized prostate cancer. Qual Life Res. 2019;28 (3):677-686. doi: 10.1007/s11136-018-2069-z. PubMed PMID:30511254 PubMed Central PMC6394517.
2. Aula, H, Skyttä, T, Tuohinen, S, Luukkaala, T, Hämäläinen, M, Virtanen, V et al.. Decreases in TGF-β1 and PDGF levels are associated with echocardiographic changes during adjuvant radiotherapy for breast cancer. Radiat Oncol. 2018;13 (1):201. doi: 10.1186/s13014-018-1150-7. PubMed PMID:30340644 PubMed Central PMC6194684.
3. Wu, X, Reinikainen, P, Kapanen, M, Vierikko, T, Ryymin, P, Kellokumpu-Lehtinen, PL et al.. Dynamic Contrast-Enhanced Imaging as a Prognostic Tool in Early Diagnosis of Prostate Cancer: Correlation with PSA and Clinical Stage. Contrast Media Mol Imaging. 2018;2018 :3181258. doi: 10.1155/2018/3181258. PubMed PMID:30327584 PubMed Central PMC6169212.
4. Leivonen, SK, Pollari, M, Brück, O, Pellinen, T, Autio, M, Karjalainen-Lindsberg, ML et al.. T-cell inflamed tumor microenvironment predicts favorable prognosis in primary testicular lymphoma. Haematologica. 2019;104 (2):338-346. doi: 10.3324/haematol.2018.200105. PubMed PMID:30237271 PubMed Central PMC6355505.
5. Kaikkonen, E, Rantapero, T, Zhang, Q, Taimen, P, Laitinen, V, Kallajoki, M et al.. ANO7 is associated with aggressive prostate cancer. Int J Cancer. 2018;143 (10):2479-2487. doi: 10.1002/ijc.31746. PubMed PMID:30157291 PubMed Central PMC6589920.
6. Pollari, M, Brück, O, Pellinen, T, Vähämurto, P, Karjalainen-Lindsberg, ML, Mannisto, S et al.. PD-L1 tumor-associated macrophages and PD-1 tumor-infiltrating lymphocytes predict survival in primary testicular lymphoma. Haematologica. 2018;103 (11):1908-1914. doi: 10.3324/haematol.2018.197194. PubMed PMID:30026337 PubMed Central PMC6278972.
7. Piili, RP, Lehto, JT, Luukkaala, T, Hinkka, H, Kellokumpu-Lehtinen, PI. Does special education in palliative medicine make a difference in end-of-life decision-making?. BMC Palliat Care. 2018;17 (1):94. doi: 10.1186/s12904-018-0349-6. PubMed PMID:30021586 PubMed Central PMC6052558.
8. Joensuu, H, Fraser, J, Wildiers, H, Huovinen, R, Auvinen, P, Utriainen, M et al.. Effect of Adjuvant Trastuzumab for a Duration of 9 Weeks vs 1 Year With Concomitant Chemotherapy for Early Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer: The SOLD Randomized Clinical Trial. JAMA Oncol. 2018;4 (9):1199-1206. doi: 10.1001/jamaoncol.2018.1380. PubMed PMID:29852043 PubMed Central PMC6143012.
9. Piili, RP, Metsänoja, R, Hinkka, H, Kellokumpu-Lehtinen, PI, Lehto, JT. Changes in attitudes towards hastened death among Finnish physicians over the past sixteen years. BMC Med Ethics. 2018;19 (1):40. doi: 10.1186/s12910-018-0290-5. PubMed PMID:29843682 PubMed Central PMC5975714.
10. Tuohinen, SS, Keski-Pukkila, K, Skyttä, T, Huhtala, H, Virtanen, V, Kellokumpu-Lehtinen, PL et al.. Radiotherapy-induced Early ECG Changes and Their Comparison with Echocardiography in Patients with Early-stage Breast Cancer. Anticancer Res. 2018;38 (4):2207-2215. doi: 10.21873/anticanres.12463. PubMed PMID:29599341 .
11. Motzer, RJ, Tannir, NM, McDermott, DF, Arén Frontera, O, Melichar, B, Choueiri, TK et al.. Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma. N Engl J Med. 2018;378 (14):1277-1290. doi: 10.1056/NEJMoa1712126. PubMed PMID:29562145 PubMed Central PMC5972549.
12. Sperinde, J, Huang, W, Vehtari, A, Chenna, A, Kellokumpu-Lehtinen, PL, Winslow, J et al.. p95HER2 Methionine 611 Carboxy-Terminal Fragment Is Predictive of Trastuzumab Adjuvant Treatment Benefit in the FinHer Trial. Clin Cancer Res. 2018;24 (13):3046-3052. doi: 10.1158/1078-0432.CCR-17-3250. PubMed PMID:29535130 .
13. Schmidt, M, Weyer-Elberich, V, Hengstler, JG, Heimes, AS, Almstedt, K, Gerhold-Ay, A et al.. Prognostic impact of CD4-positive T cell subsets in early breast cancer: a study based on the FinHer trial patient population. Breast Cancer Res. 2018;20 (1):15. doi: 10.1186/s13058-018-0942-x. PubMed PMID:29482642 PubMed Central PMC5827982.
14. Ahlgren, GM, Flodgren, P, Tammela, TLJ, Kellokumpu-Lehtinen, P, Borre, M, Angelsen, A et al.. Docetaxel Versus Surveillance After Radical Prostatectomy for High-risk Prostate Cancer: Results from the Prospective Randomised, Open-label Phase 3 Scandinavian Prostate Cancer Group 12 Trial. Eur Urol. 2018;73 (6):870-876. doi: 10.1016/j.eururo.2018.01.012. PubMed PMID:29395502 .
15. Hietanen, T, Kapanen, M, Kellokumpu-Lehtinen, PL. Natural Killer Cell Viability After Hyperthermia Alone or Combined with Radiotherapy with or without Cytokines. Anticancer Res. 2018;38 (2):655-663. doi: 10.21873/anticanres.12269. PubMed PMID:29374687 .
16. Tuohinen, SS, Rankinen, J, Skyttä, T, Huhtala, H, Virtanen, V, Kellokumpu-Lehtinen, PL et al.. Associations between ECG changes and echocardiographic findings in patients with acute non-ST elevation myocardial infarction. J Electrocardiol. 2018;51 (2):188-194. doi: 10.1016/j.jelectrocard.2017.11.007. PubMed PMID:29174705 .
17. Pajamäki, N, Metso, S, Hakala, T, Ebeling, T, Huhtala, H, Ryödi, E et al.. Long-term cardiovascular morbidity and mortality in patients treated for differentiated thyroid cancer. Clin Endocrinol (Oxf). 2018;88 (2):303-310. doi: 10.1111/cen.13519. PubMed PMID:29154445 .
18. Gillessen, S, Attard, G, Beer, TM, Beltran, H, Bossi, A, Bristow, R et al.. Management of Patients with Advanced Prostate Cancer: The Report of the Advanced Prostate Cancer Consensus Conference APCCC 2017. Eur Urol. 2018;73 (2):178-211. doi: 10.1016/j.eururo.2017.06.002. PubMed PMID:28655541 .

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Olli Lohi – Hematology and oncology

2020-2025

1. Ventelä, J, Hyoty, H, Lohi, O, Nikkilä, A. Clustering patterns in Finnish type 1 diabetes patients: a nationwide register-based study. BMJ Open Diabetes Res Care. 2025;13 (6):. doi: 10.1136/bmjdrc-2025-005547. PubMed PMID:41469087 PubMed Central PMC12766848.
2. Nikkilä, A, Lohi, O, Abrahamsson, J, Griskevicius, L, Hallböök, H, Jónsson, ÓG et al.. Intensive chemotherapy for high-risk acute lymphoblastic leukemia in first remission: results from the NOPHO ALL2008 study. Leukemia. 2026;40 (1):215-218. doi: 10.1038/s41375-025-02789-y. PubMed PMID:41145672 PubMed Central PMC12789026.
3. Pfaff, E, Schramm, K, Blattner-Johnson, M, Jones, BC, Stark, S, Balasubramanian, GP et al.. Molecular characterization and clinical features of diffuse midline glioma in the pediatric precision oncology registry INFORM. Acta Neuropathol. 2025;150 (1):42. doi: 10.1007/s00401-025-02945-9. PubMed PMID:41076459 PubMed Central PMC12515216.
4. Ahlgren, L, Pilheden, M, Sturesson, H, Song, G, Walsh, MP, Yang, M et al.. The genomic landscape of relapsed infant and childhood KMT2A-rearranged acute leukemia. Nat Commun. 2025;16 (1):8964. doi: 10.1038/s41467-025-64190-8. PubMed PMID:41062506 PubMed Central PMC12508131.
5. Kolbeinsdottir, S, Zachariadis, V, Sommerauer, C, Lohi, O, Heinäniemi, M, Enge, M et al.. Absolute copy number aware CNV calling of sub-megabase segments in ultra-low coverage single-cell DNA sequencing data. Nucleic Acids Res. 2025;53 (17):. doi: 10.1093/nar/gkaf919. PubMed PMID:40973453 PubMed Central PMC12449080.
6. Yang, T, Rasmussen, ASB, Weimann, A, Thastrup, M, Rank, CU, Als-Nielsen, B et al.. Published Population Pharmacokinetic Models of Imatinib Perform Poorly on TDM Data from Pediatric Patients. Target Oncol. 2025;20 (5):871-886. doi: 10.1007/s11523-025-01172-2. PubMed PMID:40920292 PubMed Central PMC12454585.
7. Ventelä, J, Pellikka, I, Auvinen, A, Lohi, O, Nikkilä, A. Childhood acute leukemia and type 1 diabetes in children: A nationwide case-control study. Int J Cancer. 2026;158 (4):924-930. doi: 10.1002/ijc.70122. PubMed PMID:40892039 PubMed Central PMC12712364.
8. Oksa, L, Moisio, S, Maqbool, K, Kramer, R, Nikkilä, A, Jayasingha, B et al.. Genomic determinants of therapy response in ETV6::RUNX1 leukemia. Leukemia. 2025;39 (9):2125-2139. doi: 10.1038/s41375-025-02683-7. PubMed PMID:40634509 PubMed Central PMC12380598.
9. Immonen, E, Paulamäki, L, Piippo, H, Nikkilä, A, Aine, L, Peltomäki, T et al.. Oral microbiome diversity and composition before and after chemotherapy treatment in pediatric oncology patients. BMC Oral Health. 2025;25 (1):981. doi: 10.1186/s12903-025-06405-4. PubMed PMID:40604730 PubMed Central PMC12220142.
10. Fischer, TT, Maaß, KK, Puranachot, P, Mieskolainen, M, Sill, M, Schad, PS et al.. Ultra-low-input cell-free DNA sequencing for tumor detection and characterization in a real-world pediatric brain tumor cohort. Acta Neuropathol Commun. 2025;13 (1):134. doi: 10.1186/s40478-025-02024-w. PubMed PMID:40579709 PubMed Central PMC12205504.
11. Harju, T, Raiskila, S, Lohi, O, Järvelä, L, Niinimäki, R. Increased incidence of autoimmune haemolytic anaemia with paroxysmal cold haemoglobinuria features in paediatric cases in a changing viral environment post-COVID-19 pandemic. Br J Haematol. 2025;206 (6):1872-1876. doi: 10.1111/bjh.20128. PubMed PMID:40342099 .
12. Ventelä, J, Korja, M, Auvinen, A, Lohi, O, Nikkilä, A. Clustering of childhood acute leukemia in Finland: a nationwide register-based study. Cancer Causes Control. 2025;36 (9):957-964. doi: 10.1007/s10552-025-01998-1. PubMed PMID:40272762 PubMed Central PMC12380987.
13. Abuhamed, J, Nikkilä, A, Raitanen, J, Lohi, O, Auvinen, A. Risk of childhood brain tumors after exposure to CT radiation: A nationwide population-based case-control study in Finland. Int J Cancer. 2025;156 (11):2148-2157. doi: 10.1002/ijc.35318. PubMed PMID:40184229 .
14. Valima, E, Varis, V, Bureiko, K, Lempiäinen, JK, Schroderus, AM, Oksa, L et al.. SUMOylation inhibition potentiates the glucocorticoid receptor to program growth arrest of acute lymphoblastic leukemia cells. Oncogene. 2025;44 (18):1259-1271. doi: 10.1038/s41388-025-03305-3. PubMed PMID:39953147 PubMed Central PMC12048349.
15. Kusterer, M, Lahnalampi, M, Voutilainen, M, Brand, A, Pennisi, S, Norona, J et al.. Dynamic evolution of TCF3-PBX1 leukemias at the single-cell level under chemotherapy pressure. Hemasphere. 2025;9 (2):e70071. doi: 10.1002/hem3.70071. PubMed PMID:39901941 PubMed Central PMC11788586.

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Johanna Mäenpää – Gynaecological oncology

2020-2025

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1. Ray-Coquard, I, Pautier, P, Pignata, S, Pérol, D, González-Martín, A, Berger, R et al.. Olaparib plus Bevacizumab as First-Line Maintenance in Ovarian Cancer. N Engl J Med. 2019;381 (25):2416-2428. doi: 10.1056/NEJMoa1911361. PubMed PMID:31851799 .
2. Antila, RM, Mäenpää, JU, Huhtala, HS, Tomás, EI, Staff, SM. Association of cesarean scar defect with abnormal uterine bleeding: The results of a prospective study. Eur J Obstet Gynecol Reprod Biol. 2020;244 :134-140. doi: 10.1016/j.ejogrb.2019.11.021. PubMed PMID:31785470 .
3. González-Martín, A, Pothuri, B, Vergote, I, DePont Christensen, R, Graybill, W, Mirza, MR et al.. Niraparib in Patients with Newly Diagnosed Advanced Ovarian Cancer. N Engl J Med. 2019;381 (25):2391-2402. doi: 10.1056/NEJMoa1910962. PubMed PMID:31562799 .
4. Mirza, MR, Åvall Lundqvist, E, Birrer, MJ, dePont Christensen, R, Nyvang, GB, Malander, S et al.. Niraparib plus bevacizumab versus niraparib alone for platinum-sensitive recurrent ovarian cancer (NSGO-AVANOVA2/ENGOT-ov24): a randomised, phase 2, superiority trial. Lancet Oncol. 2019;20 (10):1409-1419. doi: 10.1016/S1470-2045(19)30515-7. PubMed PMID:31474354 .
5. Kares, S, Veijalainen, O, Kholová, I, Tirkkonen, M, Vuento, R, Huhtala, H et al.. HIGH-RISK HPV testing as the primary screening method in an organized regional screening program for cervical cancer: the value of HPV16 and HPV18 genotyping?. APMIS. 2019;127 (11):710-716. doi: 10.1111/apm.12990. PubMed PMID:31403733 .
6. Mirza, MR, Bergmann, TK, Mau-Sørensen, M, Christensen, RD, Åvall-Lundqvist, E, Birrer, MJ et al.. A phase I study of the PARP inhibitor niraparib in combination with bevacizumab in platinum-sensitive epithelial ovarian cancer: NSGO AVANOVA1/ENGOT-OV24. Cancer Chemother Pharmacol. 2019;84 (4):791-798. doi: 10.1007/s00280-019-03917-z. PubMed PMID:31375879 .
7. Falconer, H, Palsdottir, K, Stalberg, K, Dahm-Kähler, P, Ottander, U, Lundin, ES et al.. Robot-assisted approach to cervical cancer (RACC): an international multi-center, open-label randomized controlled trial. Int J Gynecol Cancer. 2019;29 (6):1072-1076. doi: 10.1136/ijgc-2019-000558. PubMed PMID:31203203 .
8. Aalto, AP, Huhtala, H, Mäenpää, J, Staff, S. Combination of Treatments With or Without Surgery in Localized Provoked Vulvodynia: Outcomes After Three Years of Follow-Up. Biores Open Access. 2019;8 (1):25-31. doi: 10.1089/biores.2018.0044. PubMed PMID:30867980 PubMed Central PMC6415354.
9. Bhatla, N, Berek, JS, Cuello Fredes, M, Denny, LA, Grenman, S, Karunaratne, K et al.. Revised FIGO staging for carcinoma of the cervix uteri. Int J Gynaecol Obstet. 2019;145 (1):129-135. doi: 10.1002/ijgo.12749. PubMed PMID:30656645 .
10. Lagerstedt, M, Huotari-Orava, R, Nyberg, R, Nissinen, L, Farshchian, M, Laasanen, SL et al.. Tumor cell-specific Serpin A1 expression in vulvar squamous cell carcinoma. Arch Gynecol Obstet. 2019;299 (5):1345-1351. doi: 10.1007/s00404-018-5015-y. PubMed PMID:30607583 PubMed Central PMC6475512.
11. Veijalainen, O, Kares, S, Kujala, P, Vuento, R, Osuala, V, Tirkkonen, M et al.. Implementation of HPV-based cervical cancer screening in an organised regional screening programme: 3 years of experience. Cytopathology. 2019;30 (2):150-156. doi: 10.1111/cyt.12652. PubMed PMID:30421573 .

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Daniela Ungureanu – Cancer Signalling

2020-2024

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1. Piki, E, Dini, A, Raivola, J, Salokas, K, Zhang, K, Varjosalo, M et al.. ROR1-STAT3 signaling contributes to ovarian cancer intra-tumor heterogeneity. Cell Death Discov. 2023;9 (1):222. doi: 10.1038/s41420-023-01527-6. PubMed PMID:37400436 PubMed Central PMC10317980.
2. Murumägi, A, Ungureanu, D, Khan, S, Arjama, M, Välimäki, K, Ianevski, A et al.. Drug response profiles in patient-derived cancer cells across histological subtypes of ovarian cancer: real-time therapy tailoring for a patient with low-grade serous carcinoma. Br J Cancer. 2023;128 (4):678-690. doi: 10.1038/s41416-022-02067-z. PubMed PMID:36476658 PubMed Central PMC9938120.

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1. Murumägi, A, Ungureanu, D, Khan, S, Arjama, M, Välimäki, K, Ianevski, A et al.. Drug response profiles in patient-derived cancer cells across histological subtypes of ovarian cancer: real-time therapy tailoring for a patient with low-grade serous carcinoma. Br J Cancer. 2023;128 (4):678-690. doi: 10.1038/s41416-022-02067-z. PubMed PMID:36476658 PubMed Central PMC9938120.
2. Raivola, J, Dini, A, Karvonen, H, Piki, E, Salokas, K, Niininen, W et al.. Multiomics characterization implicates PTK7 in ovarian cancer EMT and cell plasticity and offers strategies for therapeutic intervention. Cell Death Dis. 2022;13 (8):714. doi: 10.1038/s41419-022-05161-5. PubMed PMID:35977930 PubMed Central PMC9386025.
3. Karvonen, H, Raivola, J, Ungureanu, D. Cellular thermal shift assay (CETSA) for determining the drug binding affinity using Ba/F3 clones stably expressing receptor pseudokinases. Methods Enzymol. 2022;667 :339-363. doi: 10.1016/bs.mie.2022.03.038. PubMed PMID:35525546 .
4. Raivola, J, Dini, A, Salokas, K, Karvonen, H, Niininen, W, Piki, E et al.. New insights into the molecular mechanisms of ROR1, ROR2, and PTK7 signaling from the proteomics and pharmacological modulation of ROR1 interactome. Cell Mol Life Sci. 2022;79 (5):276. doi: 10.1007/s00018-022-04301-6. PubMed PMID:35504983 PubMed Central PMC9064840.
5. Kohtamäki, L, Arjama, M, Mäkelä, S, Ianevski, P, Välimäki, K, Juteau, S et al.. High-throughput ex vivo drug testing identifies potential drugs and drug combinations for NRAS-positive malignant melanoma. Transl Oncol. 2022;15 (1):101290. doi: 10.1016/j.tranon.2021.101290. PubMed PMID:34837846 PubMed Central PMC8633005.

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Tapio Visakorpi – Molecular Biology of Prostate Cancer

2020-2025

1. Sattari, M, Rauhala, H, Latonen, L, Isaacs, WB, Nykter, M, Bova, GS et al.. Identification of protein-coding genes associated with metastatic prostate cancer. Endocr Relat Cancer. 2025;32 (7):. doi: 10.1530/ERC-25-0070. PubMed PMID:40525903 PubMed Central PMC12203752.
2. Lawlor, A, Beyer, K, Russell, B, Steinbeisser, C, Bjartell, A, De Meulder, B et al.. PIONEER big data platform for prostate cancer: lessons for advancing future real-world evidence research. Nat Rev Urol. 2025;22 (2):116-124. doi: 10.1038/s41585-024-00925-4. PubMed PMID:39251785 .

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1. Kiviaho, A, Eerola, SK, Kallio, HML, Andersen, MK, Hoikka, M, Tiihonen, AM et al.. Single cell and spatial transcriptomics highlight the interaction of club-like cells with immunosuppressive myeloid cells in prostate cancer. Nat Commun. 2024;15 (1):9949. doi: 10.1038/s41467-024-54364-1. PubMed PMID:39550375 PubMed Central PMC11569175.
2. Lawlor, A, Beyer, K, Russell, B, Steinbeisser, C, Bjartell, A, De Meulder, B et al.. PIONEER big data platform for prostate cancer: lessons for advancing future real-world evidence research. Nat Rev Urol. 2025;22 (2):116-124. doi: 10.1038/s41585-024-00925-4. PubMed PMID:39251785 .
3. Kohvakka, A, Sattari, M, Nättinen, J, Aapola, U, Gregorová, P, Tammela, TLJ et al.. Long noncoding RNA EPCART regulates translation through PI3K/AKT/mTOR pathway and PDCD4 in prostate cancer. Cancer Gene Ther. 2024;31 (10):1536-1546. doi: 10.1038/s41417-024-00822-3. PubMed PMID:39147845 PubMed Central PMC11489079.
4. Olotu, O, Koskenniemi, AR, Ma, L, Paramonov, V, Laasanen, S, Louramo, E et al.. Germline-specific RNA helicase DDX4 forms cytoplasmic granules in cancer cells and promotes tumor growth. Cell Rep. 2024;43 (7):114430. doi: 10.1016/j.celrep.2024.114430. PubMed PMID:38963760 .
5. Russell, B, Beyer, K, Lawlor, A, Roobol, MJ, Venderbos, LDF, Remmers, S et al.. Survivorship Data in Prostate Cancer: Where Are We and Where Do We Need To Be?. Eur Urol Open Sci. 2024;59 :27-29. doi: 10.1016/j.euros.2023.11.004. PubMed PMID:38298764 PubMed Central PMC10829596.

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1. Russell, B, Beyer, K, Lawlor, A, Roobol, MJ, Venderbos, LDF, Remmers, S et al.. Survivorship Data in Prostate Cancer: Where Are We and Where Do We Need To Be?. Eur Urol Open Sci. 2024;59 :27-29. doi: 10.1016/j.euros.2023.11.004. PubMed PMID:38298764 PubMed Central PMC10829596.
2. Nurminen, A, Jaatinen, S, Taavitsainen, S, Högnäs, G, Lesluyes, T, Ansari-Pour, N et al.. Cancer origin tracing and timing in two high-risk prostate cancers using multisample whole genome analysis: prospects for personalized medicine. Genome Med. 2023;15 (1):82. doi: 10.1186/s13073-023-01242-y. PubMed PMID:37828555 PubMed Central PMC10571458.
3. Sattari, M, Kohvakka, A, Moradi, E, Rauhala, H, Urhonen, H, Isaacs, WB et al.. Identification of long noncoding RNAs with aberrant expression in prostate cancer metastases. Endocr Relat Cancer. 2023;30 (8):. doi: 10.1530/ERC-22-0247. PubMed PMID:37140987 PubMed Central PMC10326635.
4. Omar, MI, MacLennan, S, Ribal, MJ, Roobol, MJ, Dimitropoulos, K, van den Broeck, T et al.. Unanswered questions in prostate cancer – findings of an international multi-stakeholder consensus by the PIONEER consortium. Nat Rev Urol. 2023;20 (8):494-501. doi: 10.1038/s41585-023-00748-9. PubMed PMID:37012441 .
5. Yakneen, S, Waszak, SM, PCAWG Technical Working Group, Gertz, M, Korbel, JO, PCAWG Consortium et al.. Author Correction: Butler enables rapid cloud-based analysis of thousands of human genomes. Nat Biotechnol. 2023;41 (4):577. doi: 10.1038/s41587-022-01554-1. PubMed PMID:36944844 PubMed Central PMC10110458.
6. Rodriguez-Martin, B, Alvarez, EG, Baez-Ortega, A, Zamora, J, Supek, F, Demeulemeester, J et al.. Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition. Nat Genet. 2023;55 (6):1080. doi: 10.1038/s41588-023-01319-9. PubMed PMID:36944736 PubMed Central PMC10260396.
7. Akdemir, KC, Le, VT, Chandran, S, Li, Y, Verhaak, RG, Beroukhim, R et al.. Author Correction: Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer. Nat Genet. 2023;55 (6):1079. doi: 10.1038/s41588-023-01318-w. PubMed PMID:36944735 PubMed Central PMC10260394.
8. Zapatka, M, Borozan, I, Brewer, DS, Iskar, M, Grundhoff, A, Alawi, M et al.. Author Correction: The landscape of viral associations in human cancers. Nat Genet. 2023;55 (6):1077. doi: 10.1038/s41588-023-01316-y. PubMed PMID:36944734 PubMed Central PMC10260395.
9. Cortés-Ciriano, I, Lee, JJ, Xi, R, Jain, D, Jung, YL, Yang, L et al.. Author Correction: Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing. Nat Genet. 2023;55 (6):1076. doi: 10.1038/s41588-023-01315-z. PubMed PMID:36944733 PubMed Central PMC10260391.
10. Yuan, Y, Ju, YS, Kim, Y, Li, J, Wang, Y, Yoon, CJ et al.. Author Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers. Nat Genet. 2023;55 (6):1078. doi: 10.1038/s41588-023-01317-x. PubMed PMID:36944732 PubMed Central PMC10260393.
11. Alexandrov, LB, Kim, J, Haradhvala, NJ, Huang, MN, Tian Ng, AW, Wu, Y et al.. Author Correction: The repertoire of mutational signatures in human cancer. Nature. 2023;614 (7948):E41. doi: 10.1038/s41586-022-05600-5. PubMed PMID:36697836 PubMed Central PMC9931578.
12. Li, Y, Roberts, ND, Wala, JA, Shapira, O, Schumacher, SE, Kumar, K et al.. Author Correction: Patterns of somatic structural variation in human cancer genomes. Nature. 2023;614 (7948):E38. doi: 10.1038/s41586-022-05597-x. PubMed PMID:36697835 PubMed Central PMC9931568.
13. ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium. Author Correction: Pan-cancer analysis of whole genomes. Nature. 2023;614 (7948):E39. doi: 10.1038/s41586-022-05598-w. PubMed PMID:36697834 PubMed Central PMC9931570.
14. Gerstung, M, Jolly, C, Leshchiner, I, Dentro, SC, Gonzalez, S, Rosebrock, D et al.. Author Correction: The evolutionary history of 2,658 cancers. Nature. 2023;614 (7948):E42. doi: 10.1038/s41586-022-05601-4. PubMed PMID:36697833 PubMed Central PMC9931577.
15. Rheinbay, E, Nielsen, MM, Abascal, F, Wala, JA, Shapira, O, Tiao, G et al.. Author Correction: Analyses of non-coding somatic drivers in 2,658 cancer whole genomes. Nature. 2023;614 (7948):E40. doi: 10.1038/s41586-022-05599-9. PubMed PMID:36697832 PubMed Central PMC9931557.
16. PCAWG Transcriptome Core Group, Calabrese, C, Davidson, NR, Demircioğlu, D, Fonseca, NA, He, Y et al.. Author Correction: Genomic basis for RNA alterations in cancer. Nature. 2023;614 (7948):E37. doi: 10.1038/s41586-022-05596-y. PubMed PMID:36697831 PubMed Central PMC9931574.
17. Siltari, A, Lönnerbro, R, Pang, K, Shiranov, K, Asiimwe, A, Evans-Axelsson, S et al.. How Well do Polygenic Risk Scores Identify Men at High Risk for Prostate Cancer? Systematic Review and Meta-Analysis. Clin Genitourin Cancer. 2023;21 (2):316.e1-316.e11. doi: 10.1016/j.clgc.2022.09.006. PubMed PMID:36243664 .

Search PubMed

1. Bögemann, M, Shore, ND, Smith, MR, Tammela, TLJ, Ulys, A, Vjaters, E et al.. Erratum to “Efficacy and Safety of Darolutamide in Patients with Nonmetastatic Castration-resistant Prostate Cancer Stratified by Prostate-specific Antigen Doubling Time: Planned Subgroup Analysis of the Phase 3 ARAMIS Trial” [Eur Urol 2022]. Eur Urol. 2023;83 (2):e60. doi: 10.1016/j.eururo.2022.11.018. PubMed PMID:36526492 .
2. Carlevaro-Fita, J, Lanzós, A, Feuerbach, L, Hong, C, Mas-Ponte, D, Pedersen, JS et al.. Author Correction: Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis. Commun Biol. 2022;5 (1):1347. doi: 10.1038/s42003-022-03769-z. PubMed PMID:36482178 PubMed Central PMC9732278.
3. Rubanova, Y, Shi, R, Harrigan, CF, Li, R, Wintersinger, J, Sahin, N et al.. Author Correction: Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig. Nat Commun. 2022;13 (1):7567. doi: 10.1038/s41467-022-32336-7. PubMed PMID:36482170 PubMed Central PMC9731941.
4. Sieverling, L, Hong, C, Koser, SD, Ginsbach, P, Kleinheinz, K, Hutter, B et al.. Author Correction: Genomic footprints of activated telomere maintenance mechanisms in cancer. Nat Commun. 2022;13 (1):7574. doi: 10.1038/s41467-022-32328-7. PubMed PMID:36481818 PubMed Central PMC9731961.
5. Shuai, S, PCAWG Drivers and Functional Interpretation Working Group, Gallinger, S, Stein, LD, PCAWG Consortium. Author Correction: Combined burden and functional impact tests for cancer driver discovery using DriverPower. Nat Commun. 2022;13 (1):7571. doi: 10.1038/s41467-022-32343-8. PubMed PMID:36481739 PubMed Central PMC9732291.
6. Cmero, M, Yuan, K, Ong, CS, Schröder, J, PCAWG Evolution and Heterogeneity Working Group, Corcoran, NM et al.. Author Correction: Inferring structural variant cancer cell fraction. Nat Commun. 2022;13 (1):7568. doi: 10.1038/s41467-022-32338-5. PubMed PMID:36481724 PubMed Central PMC9732297.
7. Jiao, W, Atwal, G, Polak, P, Karlic, R, Cuppen, E, PCAWG Tumor Subtypes and Clinical Translation Working Group et al.. Author Correction: A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns. Nat Commun. 2022;13 (1):7573. doi: 10.1038/s41467-022-32329-6. PubMed PMID:36481665 PubMed Central PMC9732335.
8. Paczkowska, M, Barenboim, J, Sintupisut, N, Fox, NS, Zhu, H, Abd-Rabbo, D et al.. Author Correction: Integrative pathway enrichment analysis of multivariate omics data. Nat Commun. 2022;13 (1):7570. doi: 10.1038/s41467-022-32342-9. PubMed PMID:36481658 PubMed Central PMC9731958.
9. Zhang, Y, Chen, F, Fonseca, NA, He, Y, Fujita, M, Nakagawa, H et al.. Author Correction: High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations. Nat Commun. 2022;13 (1):7572. doi: 10.1038/s41467-022-32333-w. PubMed PMID:36481652 PubMed Central PMC9732340.
10. Bhandari, V, Li, CH, Bristow, RG, Boutros, PC, PCAWG Consortium. Author Correction: Divergent mutational processes distinguish hypoxic and normoxic tumours. Nat Commun. 2022;13 (1):7569. doi: 10.1038/s41467-022-32339-4. PubMed PMID:36481612 PubMed Central PMC9731962.
11. Reyna, MA, Haan, D, Paczkowska, M, Verbeke, LPC, Vazquez, M, Kahraman, A et al.. Author Correction: Pathway and network analysis of more than 2500 whole cancer genomes. Nat Commun. 2022;13 (1):7566. doi: 10.1038/s41467-022-32334-9. PubMed PMID:36481610 PubMed Central PMC9732045.
12. Nygård, LH, Talala, K, Taari, K, Tammela, TLJ, Auvinen, A, Murtola, TJ et al.. Antidiabetic drugs, glycemic control and risk of benign prostatic hyperplasia. Prostate. 2023;83 (3):246-258. doi: 10.1002/pros.24456. PubMed PMID:36325820 .
13. Bernard, D, Martinez-Leal, JF, Rizzo, S, Martinez, D, Hudson, D, Visakorpi, T et al.. Retraction Note: CBX7 controls the growth of normal and tumor-derived prostate cells by repressing the Ink4a/Arf locus. Oncogene. 2022;41 (45):4980. doi: 10.1038/s41388-022-02502-8. PubMed PMID:36253447 .
14. Siltari, A, Lönnerbro, R, Pang, K, Shiranov, K, Asiimwe, A, Evans-Axelsson, S et al.. How Well do Polygenic Risk Scores Identify Men at High Risk for Prostate Cancer? Systematic Review and Meta-Analysis. Clin Genitourin Cancer. 2023;21 (2):316.e1-316.e11. doi: 10.1016/j.clgc.2022.09.006. PubMed PMID:36243664 .
15. Kukkonen, K, Autio-Kimura, B, Rauhala, H, Kesseli, J, Nykter, M, Latonen, L et al.. Nonmalignant AR-positive prostate epithelial cells and cancer cells respond differently to androgen. Endocr Relat Cancer. 2022;29 (12):717-733. doi: 10.1530/ERC-22-0108. PubMed PMID:36219867 PubMed Central PMC9644224.
16. Buhigas, C, Warren, AY, Leung, WK, Whitaker, HC, Luxton, HJ, Hawkins, S et al.. The architecture of clonal expansions in morphologically normal tissue from cancerous and non-cancerous prostates. Mol Cancer. 2022;21 (1):183. doi: 10.1186/s12943-022-01644-3. PubMed PMID:36131292 PubMed Central PMC9494848.
17. Kukko, V, Kaipia, A, Talala, K, Taari, K, Tammela, TLJ, Auvinen, A et al.. Allopurinol and prostate cancer survival in a Finnish population-based cohort. Prostate Cancer Prostatic Dis. 2024;27 (1):73-80. doi: 10.1038/s41391-022-00597-4. PubMed PMID:36131010 PubMed Central PMC10876474.
18. Bögemann, M, Shore, ND, Smith, MR, Tammela, TLJ, Ulys, A, Vjaters, E et al.. Efficacy and Safety of Darolutamide in Patients with Nonmetastatic Castration-resistant Prostate Cancer Stratified by Prostate-specific Antigen Doubling Time: Planned Subgroup Analysis of the Phase 3 ARAMIS Trial. Eur Urol. 2023;83 (3):212-221. doi: 10.1016/j.eururo.2022.07.018. PubMed PMID:36089529 .
19. Peltomaa, AI, Talala, K, Taari, K, Tammela, TLJ, Auvinen, A, Murtola, TJ et al.. Inverse Association between Statin Use and Cancer Mortality Relates to Cholesterol Level. Cancers (Basel). 2022;14 (12):. doi: 10.3390/cancers14122920. PubMed PMID:35740586 PubMed Central PMC9221017.
20. Salminen, JK, Mehtola, A, Talala, K, Taari, K, Mäkinen, J, Peltola, J et al.. Anti-epileptic drugs and prostate cancer-specific mortality compared to non-users of anti-epileptic drugs in the Finnish Randomized Study of Screening for Prostate Cancer. Br J Cancer. 2022;127 (4):704-711. doi: 10.1038/s41416-022-01817-3. PubMed PMID:35505251 PubMed Central PMC9381528.
21. Åkerla, J, Pesonen, JS, Pöyhönen, A, Koskimäki, J, Häkkinen, J, Huhtala, H et al.. Lower Urinary Tract Symptoms and Mortality among Finnish Men: The Roles of Symptom Severity and Bother. J Urol. 2022;207 (6):1285-1294. doi: 10.1097/JU.0000000000002450. PubMed PMID:35470712 .
22. Scaravilli, M, Koivukoski, S, Gillen, A, Bouazza, A, Ruusuvuori, P, Visakorpi, T et al.. miR-32 promotes MYC-driven prostate cancer. Oncogenesis. 2022;11 (1):11. doi: 10.1038/s41389-022-00385-8. PubMed PMID:35228520 PubMed Central PMC8885642.
23. Smith, MR, Hussain, M, Saad, F, Fizazi, K, Sternberg, CN, Crawford, ED et al.. Darolutamide and Survival in Metastatic, Hormone-Sensitive Prostate Cancer. N Engl J Med. 2022;386 (12):1132-1142. doi: 10.1056/NEJMoa2119115. PubMed PMID:35179323 PubMed Central PMC9844551.
24. Jeyapala, R, Kamdar, S, Olkhov-Mitsel, E, Zlotta, A, Fleshner, N, Visakorpi, T et al.. Combining CAPRA-S With Tumor IDC/C Features Improves the Prognostication of Biochemical Recurrence in Prostate Cancer Patients. Clin Genitourin Cancer. 2022;20 (3):e217-e226. doi: 10.1016/j.clgc.2022.01.003. PubMed PMID:35151601 .
25. Ruusuvuori, P, Valkonen, M, Kartasalo, K, Valkonen, M, Visakorpi, T, Nykter, M et al.. Spatial analysis of histology in 3D: quantification and visualization of organ and tumor level tissue environment. Heliyon. 2022;8 (1):e08762. doi: 10.1016/j.heliyon.2022.e08762. PubMed PMID:35128089 PubMed Central PMC8800033.
26. Eskelinen, T, Veitonmäki, T, Kotsar, A, Tammela, TLJ, Pöyhönen, A, Murtola, TJ et al.. Improved renal cancer prognosis among users of drugs targeting renin-angiotensin system. Cancer Causes Control. 2022;33 (2):313-320. doi: 10.1007/s10552-021-01527-w. PubMed PMID:34921656 PubMed Central PMC8776666.
27. Vettenranta, A, Murtola, TJ, Raitanen, J, Raittinen, P, Talala, K, Taari, K et al.. Outcomes of Screening for Prostate Cancer Among Men Who Use Statins. JAMA Oncol. 2022;8 (1):61-68. doi: 10.1001/jamaoncol.2021.5672. PubMed PMID:34817559 PubMed Central PMC8777566.
28. Pöyhönen, A, Åkerla, J, Koskimäki, J, Tammela, TLJ, Auvinen, A. Sauna habits/bathing and changes in lower urinary tract symptoms – Tampere Ageing Male Urologic Study (TAMUS). Scand J Urol. 2022;56 (1):77-82. doi: 10.1080/21681805.2021.2002403. PubMed PMID:34783288 .

Search PubMed

1. Eskelinen, T, Veitonmäki, T, Kotsar, A, Tammela, TLJ, Pöyhönen, A, Murtola, TJ et al.. Improved renal cancer prognosis among users of drugs targeting renin-angiotensin system. Cancer Causes Control. 2022;33 (2):313-320. doi: 10.1007/s10552-021-01527-w. PubMed PMID:34921656 PubMed Central PMC8776666.
2. Pöyhönen, A, Åkerla, J, Koskimäki, J, Tammela, TLJ, Auvinen, A. Sauna habits/bathing and changes in lower urinary tract symptoms – Tampere Ageing Male Urologic Study (TAMUS). Scand J Urol. 2022;56 (1):77-82. doi: 10.1080/21681805.2021.2002403. PubMed PMID:34783288 .
3. Beyer, K, MacLennan, SJ, Moris, L, Lardas, M, Mastris, K, Hooker, G et al.. The Key Role of Patient Involvement in the Development of Core Outcome Sets in Prostate Cancer. Eur Urol Focus. 2021;7 (5):943-946. doi: 10.1016/j.euf.2021.09.008. PubMed PMID:34602368 .
4. Taavitsainen, S, Engedal, N, Cao, S, Handle, F, Erickson, A, Prekovic, S et al.. Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse. Nat Commun. 2021;12 (1):5307. doi: 10.1038/s41467-021-25624-1. PubMed PMID:34489465 PubMed Central PMC8421417.
5. Raittinen, PVH, Syvälä, H, Tammela, TLJ, Häkkinen, MR, Ilmonen, P, Auriola, S et al.. Atorvastatin induces adrenal androgen downshift in men with prostate cancer: A post Hoc analysis of a pilot adaptive Randomised clinical trial. EBioMedicine. 2021;68 :103432. doi: 10.1016/j.ebiom.2021.103432. PubMed PMID:34144486 PubMed Central PMC8219992.
6. Launonen, KM, Paakinaho, V, Sigismondo, G, Malinen, M, Sironen, R, Hartikainen, JM et al.. Chromatin-directed proteomics-identified network of endogenous androgen receptor in prostate cancer cells. Oncogene. 2021;40 (27):4567-4579. doi: 10.1038/s41388-021-01887-2. PubMed PMID:34127815 PubMed Central PMC8266679.
7. Sipeky, C, Tammela, TLJ, Auvinen, A, Schleutker, J. Novel prostate cancer susceptibility gene SP6 predisposes patients to aggressive disease. Prostate Cancer Prostatic Dis. 2021;24 (4):1158-1166. doi: 10.1038/s41391-021-00378-5. PubMed PMID:34012061 PubMed Central PMC8616752.
8. Eerola, SK, Kohvakka, A, Tammela, TLJ, Koskinen, PJ, Latonen, L, Visakorpi, T et al.. Expression and ERG regulation of PIM kinases in prostate cancer. Cancer Med. 2021;10 (10):3427-3436. doi: 10.1002/cam4.3893. PubMed PMID:33932111 PubMed Central PMC8124112.
9. Vettenranta, A, Murtola, TJ, Talala, K, Taari, K, Stenman, UH, Tammela, TLJ et al.. Outcomes of prostate cancer screening among men using antidiabetic medication. Sci Rep. 2021;11 (1):7363. doi: 10.1038/s41598-021-86534-2. PubMed PMID:33795720 PubMed Central PMC8016840.
10. Peltomaa, AI, Raittinen, P, Talala, K, Taari, K, Tammela, TLJ, Auvinen, A et al.. Prostate cancer prognosis after initiation of androgen deprivation therapy among statin users. A population-based cohort study. Prostate Cancer Prostatic Dis. 2021;24 (3):917-924. doi: 10.1038/s41391-021-00351-2. PubMed PMID:33790420 PubMed Central PMC8384625.
11. Vihervuori, VJ, Talala, K, Taari, K, Lahtela, J, Tammela, TLJ, Auvinen, A et al.. Antidiabetic Drugs and Prostate Cancer Prognosis in a Finnish Population-Based Cohort. Cancer Epidemiol Biomarkers Prev. 2021;30 (5):982-989. doi: 10.1158/1055-9965.EPI-19-0580. PubMed PMID:33653815 .
12. Salminen, JK, Kuoppamäki, V, Talala, K, Taari, K, Mäkinen, J, Peltola, J et al.. Antiepileptic drugs and prostate cancer risk in the Finnish Randomized Study of Screening for Prostate Cancer. Int J Cancer. 2021;149 (2):307-315. doi: 10.1002/ijc.33535. PubMed PMID:33634851 .
13. Beyer, K, Moris, L, Lardas, M, Haire, A, Barletta, F, Scuderi, S et al.. Diagnostic and prognostic factors in patients with prostate cancer: a systematic review protocol. BMJ Open. 2021;11 (2):e040531. doi: 10.1136/bmjopen-2020-040531. PubMed PMID:33574142 PubMed Central PMC7880102.
14. Neupane, S, Nevalainen, J, Raitanen, J, Talala, K, Kujala, P, Taari, K et al.. Prognostic Index for Predicting Prostate Cancer Survival in a Randomized Screening Trial: Development and Validation. Cancers (Basel). 2021;13 (3):. doi: 10.3390/cancers13030435. PubMed PMID:33498854 PubMed Central PMC7865328.
15. Conti, DV, Darst, BF, Moss, LC, Saunders, EJ, Sheng, X, Chou, A et al.. Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction. Nat Genet. 2021;53 (3):413. doi: 10.1038/s41588-021-00786-2. PubMed PMID:33473200 .
16. Karlsson, Q, Brook, MN, Dadaev, T, Wakerell, S, Saunders, EJ, Muir, K et al.. Rare Germline Variants in ATM Predispose to Prostate Cancer: A PRACTICAL Consortium Study. Eur Urol Oncol. 2021;4 (4):570-579. doi: 10.1016/j.euo.2020.12.001. PubMed PMID:33436325 PubMed Central PMC8381233.
17. Conti, DV, Darst, BF, Moss, LC, Saunders, EJ, Sheng, X, Chou, A et al.. Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction. Nat Genet. 2021;53 (1):65-75. doi: 10.1038/s41588-020-00748-0. PubMed PMID:33398198 PubMed Central PMC8148035.
18. Pakarainen, T, Nevalainen, J, Talala, K, Taari, K, Raitanen, J, Kujala, P et al.. Number of screening rounds attended and incidence of high-risk prostate cancer in the Finnish Randomized Study of Screening for Prostate Cancer (FinRSPC). Cancer. 2021;127 (2):188-192. doi: 10.1002/cncr.33254. PubMed PMID:33048394 .
19. Pöyhönen, A, Åkerla, J, Koskimäki, J, Tammela, TLJ, Auvinen, A. Seasonal changes in occurrence and severity of lower urinary tract symptoms-Tampere Aging Male Urologic Study (TAMUS). Low Urin Tract Symptoms. 2021;13 (2):216-223. doi: 10.1111/luts.12353. PubMed PMID:33034153 .

Search PubMed

1. Bailey, MH, Meyerson, WU, Dursi, LJ, Wang, LB, Dong, G, Liang, WW et al.. Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples. Nat Commun. 2020;11 (1):6232. doi: 10.1038/s41467-020-20128-w. PubMed PMID:33257764 PubMed Central PMC7705717.
2. Sipeky, C, Talala, KM, Tammela, TLJ, Taari, K, Auvinen, A, Schleutker, J et al.. Prostate cancer risk prediction using a polygenic risk score. Sci Rep. 2020;10 (1):17075. doi: 10.1038/s41598-020-74172-z. PubMed PMID:33051487 PubMed Central PMC7553910.
3. Pakarainen, T, Nevalainen, J, Talala, K, Taari, K, Raitanen, J, Kujala, P et al.. Number of screening rounds attended and incidence of high-risk prostate cancer in the Finnish Randomized Study of Screening for Prostate Cancer (FinRSPC). Cancer. 2021;127 (2):188-192. doi: 10.1002/cncr.33254. PubMed PMID:33048394 .
4. Hietikko, R, Kilpeläinen, TP, Kenttämies, A, Ronkainen, J, Ijäs, K, Lind, K et al.. Expected impact of MRI-related interreader variability on ProScreen prostate cancer screening trial: a pre-trial validation study. Cancer Imaging. 2020;20 (1):72. doi: 10.1186/s40644-020-00351-w. PubMed PMID:33036660 PubMed Central PMC7547469.
5. Pöyhönen, A, Åkerla, J, Koskimäki, J, Tammela, TLJ, Auvinen, A. Seasonal changes in occurrence and severity of lower urinary tract symptoms-Tampere Aging Male Urologic Study (TAMUS). Low Urin Tract Symptoms. 2021;13 (2):216-223. doi: 10.1111/luts.12353. PubMed PMID:33034153 .
6. Woodcock, DJ, Riabchenko, E, Taavitsainen, S, Kankainen, M, Gundem, G, Brewer, DS et al.. Prostate cancer evolution from multilineage primary to single lineage metastases with implications for liquid biopsy. Nat Commun. 2020;11 (1):5070. doi: 10.1038/s41467-020-18843-5. PubMed PMID:33033260 PubMed Central PMC7545111.
7. Bailey, MH, Meyerson, WU, Dursi, LJ, Wang, LB, Dong, G, Liang, WW et al.. Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples. Nat Commun. 2020;11 (1):4748. doi: 10.1038/s41467-020-18151-y. PubMed PMID:32958763 PubMed Central PMC7505971.
8. Li, CH, Prokopec, SD, Sun, RX, Yousif, F, Schmitz, N, PCAWG Tumour Subtypes and Clinical Translation et al.. Sex differences in oncogenic mutational processes. Nat Commun. 2020;11 (1):4330. doi: 10.1038/s41467-020-17359-2. PubMed PMID:32859912 PubMed Central PMC7455744.
9. Gundem, G, Van Loo, P, Kremeyer, B, Alexandrov, LB, Tubio, JMC, Papaemmanuil, E et al.. Author Correction: The evolutionary history of lethal metastatic prostate cancer. Nature. 2020;584 (7820):E18. doi: 10.1038/s41586-020-2581-5. PubMed PMID:32728210 .
10. Savolainen, K, Scaravilli, M, Ilvesmäki, A, Staff, S, Tolonen, T, Mäenpää, JU et al.. Expression of the miR-200 family in tumor tissue, plasma and urine of epithelial ovarian cancer patients in comparison to benign counterparts. BMC Res Notes. 2020;13 (1):311. doi: 10.1186/s13104-020-05155-6. PubMed PMID:32611374 PubMed Central PMC7329467.
11. Siltari, A, Murtola, TJ, Talala, K, Taari, K, Tammela, TLJ, Auvinen, A et al.. Antihypertensive drug use and prostate cancer-specific mortality in Finnish men. PLoS One. 2020;15 (6):e0234269. doi: 10.1371/journal.pone.0234269. PubMed PMID:32598349 PubMed Central PMC7323967.
12. Kohvakka, A, Sattari, M, Shcherban, A, Annala, M, Urbanucci, A, Kesseli, J et al.. AR and ERG drive the expression of prostate cancer specific long noncoding RNAs. Oncogene. 2020;39 (30):5241-5251. doi: 10.1038/s41388-020-1365-6. PubMed PMID:32555329 .
13. Karunamuni, RA, Huynh-Le, MP, Fan, CC, Eeles, RA, Easton, DF, Kote-Jarai, Z et al.. The effect of sample size on polygenic hazard models for prostate cancer. Eur J Hum Genet. 2020;28 (10):1467-1475. doi: 10.1038/s41431-020-0664-2. PubMed PMID:32514134 PubMed Central PMC7608255.
14. Talala, K, Heinävaara, S, Taari, K, Tammela, TLJ, Kujala, P, Stenman, UH et al.. Long-term health-related quality of life among men with prostate cancer in the Finnish randomized study of screening for prostate cancer. Cancer Med. 2020;9 (15):5643-5654. doi: 10.1002/cam4.3181. PubMed PMID:32500650 PubMed Central PMC7402814.
15. Stuopelyte, K, Sabaliauskaite, R, Bakavicius, A, Haflidadóttir, BS, Visakorpi, T, Väänänen, RM et al.. Reply by Authors. J Urol. 2020;204 (1):77-78. doi: 10.1097/JU.0000000000000803.02. PubMed PMID:32343215 .
16. Stuopelyte, K, Sabaliauskaite, R, Bakavicius, A, Haflidadóttir, BS, Visakorpi, T, Väänänen, RM et al.. Analysis of AR-FL and AR-V1 in Whole Blood of Patients with Castration Resistant Prostate Cancer as a Tool for Predicting Response to Abiraterone Acetate. J Urol. 2020;204 (1):71-78. doi: 10.1097/JU.0000000000000803. PubMed PMID:32068491 PubMed Central PMC7301408.
17. PCAWG Transcriptome Core Group, Calabrese, C, Davidson, NR, Demircioğlu, D, Fonseca, NA, He, Y et al.. Genomic basis for RNA alterations in cancer. Nature. 2020;578 (7793):129-136. doi: 10.1038/s41586-020-1970-0. PubMed PMID:32025019 PubMed Central PMC7054216.
18. Alexandrov, LB, Kim, J, Haradhvala, NJ, Huang, MN, Tian Ng, AW, Wu, Y et al.. The repertoire of mutational signatures in human cancer. Nature. 2020;578 (7793):94-101. doi: 10.1038/s41586-020-1943-3. PubMed PMID:32025018 PubMed Central PMC7054213.
19. Rheinbay, E, Nielsen, MM, Abascal, F, Wala, JA, Shapira, O, Tiao, G et al.. Analyses of non-coding somatic drivers in 2,658 cancer whole genomes. Nature. 2020;578 (7793):102-111. doi: 10.1038/s41586-020-1965-x. PubMed PMID:32025015 PubMed Central PMC7054214.
20. Gerstung, M, Jolly, C, Leshchiner, I, Dentro, SC, Gonzalez, S, Rosebrock, D et al.. The evolutionary history of 2,658 cancers. Nature. 2020;578 (7793):122-128. doi: 10.1038/s41586-019-1907-7. PubMed PMID:32025013 PubMed Central PMC7054212.
21. Li, Y, Roberts, ND, Wala, JA, Shapira, O, Schumacher, SE, Kumar, K et al.. Patterns of somatic structural variation in human cancer genomes. Nature. 2020;578 (7793):112-121. doi: 10.1038/s41586-019-1913-9. PubMed PMID:32025012 PubMed Central PMC7025897.
22. ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium. Pan-cancer analysis of whole genomes. Nature. 2020;578 (7793):82-93. doi: 10.1038/s41586-020-1969-6. PubMed PMID:32025007 PubMed Central PMC7025898.
23. Cortés-Ciriano, I, Lee, JJ, Xi, R, Jain, D, Jung, YL, Yang, L et al.. Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing. Nat Genet. 2020;52 (3):331-341. doi: 10.1038/s41588-019-0576-7. PubMed PMID:32025003 PubMed Central PMC7058534.
24. Zapatka, M, Borozan, I, Brewer, DS, Iskar, M, Grundhoff, A, Alawi, M et al.. The landscape of viral associations in human cancers. Nat Genet. 2020;52 (3):320-330. doi: 10.1038/s41588-019-0558-9. PubMed PMID:32025001 PubMed Central PMC8076016.
25. Akdemir, KC, Le, VT, Chandran, S, Li, Y, Verhaak, RG, Beroukhim, R et al.. Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer. Nat Genet. 2020;52 (3):294-305. doi: 10.1038/s41588-019-0564-y. PubMed PMID:32024999 PubMed Central PMC7058537.
26. Rodriguez-Martin, B, Alvarez, EG, Baez-Ortega, A, Zamora, J, Supek, F, Demeulemeester, J et al.. Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition. Nat Genet. 2020;52 (3):306-319. doi: 10.1038/s41588-019-0562-0. PubMed PMID:32024998 PubMed Central PMC7058536.
27. Yuan, Y, Ju, YS, Kim, Y, Li, J, Wang, Y, Yoon, CJ et al.. Comprehensive molecular characterization of mitochondrial genomes in human cancers. Nat Genet. 2020;52 (3):342-352. doi: 10.1038/s41588-019-0557-x. PubMed PMID:32024997 PubMed Central PMC7058535.
28. Carlevaro-Fita, J, Lanzós, A, Feuerbach, L, Hong, C, Mas-Ponte, D, Pedersen, JS et al.. Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis. Commun Biol. 2020;3 (1):56. doi: 10.1038/s42003-019-0741-7. PubMed PMID:32024996 PubMed Central PMC7002399.
29. Yakneen, S, Waszak, SM, PCAWG Technical Working Group, Gertz, M, Korbel, JO, PCAWG Consortium et al.. Butler enables rapid cloud-based analysis of thousands of human genomes. Nat Biotechnol. 2020;38 (3):288-292. doi: 10.1038/s41587-019-0360-3. PubMed PMID:32024987 PubMed Central PMC7062635.
30. Reyna, MA, Haan, D, Paczkowska, M, Verbeke, LPC, Vazquez, M, Kahraman, A et al.. Pathway and network analysis of more than 2500 whole cancer genomes. Nat Commun. 2020;11 (1):729. doi: 10.1038/s41467-020-14367-0. PubMed PMID:32024854 PubMed Central PMC7002574.
31. Jiao, W, Atwal, G, Polak, P, Karlic, R, Cuppen, E, PCAWG Tumor Subtypes and Clinical Translation Working Group et al.. A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns. Nat Commun. 2020;11 (1):728. doi: 10.1038/s41467-019-13825-8. PubMed PMID:32024849 PubMed Central PMC7002586.
32. Paczkowska, M, Barenboim, J, Sintupisut, N, Fox, NS, Zhu, H, Abd-Rabbo, D et al.. Integrative pathway enrichment analysis of multivariate omics data. Nat Commun. 2020;11 (1):735. doi: 10.1038/s41467-019-13983-9. PubMed PMID:32024846 PubMed Central PMC7002665.
33. Cmero, M, Yuan, K, Ong, CS, Schröder, J, PCAWG Evolution and Heterogeneity Working Group, Corcoran, NM et al.. Inferring structural variant cancer cell fraction. Nat Commun. 2020;11 (1):730. doi: 10.1038/s41467-020-14351-8. PubMed PMID:32024845 PubMed Central PMC7002525.
34. Rubanova, Y, Shi, R, Harrigan, CF, Li, R, Wintersinger, J, Sahin, N et al.. Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig. Nat Commun. 2020;11 (1):731. doi: 10.1038/s41467-020-14352-7. PubMed PMID:32024834 PubMed Central PMC7002414.
35. Zhang, Y, Chen, F, Fonseca, NA, He, Y, Fujita, M, Nakagawa, H et al.. High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations. Nat Commun. 2020;11 (1):736. doi: 10.1038/s41467-019-13885-w. PubMed PMID:32024823 PubMed Central PMC7002524.
36. Bhandari, V, Li, CH, Bristow, RG, Boutros, PC, PCAWG Consortium. Divergent mutational processes distinguish hypoxic and normoxic tumours. Nat Commun. 2020;11 (1):737. doi: 10.1038/s41467-019-14052-x. PubMed PMID:32024819 PubMed Central PMC7002770.
37. Shuai, S, PCAWG Drivers and Functional Interpretation Working Group, Gallinger, S, Stein, LD, PCAWG Consortium. Combined burden and functional impact tests for cancer driver discovery using DriverPower. Nat Commun. 2020;11 (1):734. doi: 10.1038/s41467-019-13929-1. PubMed PMID:32024818 PubMed Central PMC7002750.
38. Sieverling, L, Hong, C, Koser, SD, Ginsbach, P, Kleinheinz, K, Hutter, B et al.. Genomic footprints of activated telomere maintenance mechanisms in cancer. Nat Commun. 2020;11 (1):733. doi: 10.1038/s41467-019-13824-9. PubMed PMID:32024817 PubMed Central PMC7002710.
39. Granberg, KJ, Raita, A, Lehtinen, B, Tiihonen, AM, Kesseli, J, Annala, M et al.. Moderate-to-strong expression of FGFR3 and TP53 alterations in a subpopulation of choroid plexus tumors. Histol Histopathol. 2020;35 (7):673-680. doi: 10.14670/HH-18-180. PubMed PMID:31660579 .

Search PubMed

1. Eerola, SK, Santio, NM, Rinne, S, Kouvonen, P, Corthals, GL, Scaravilli, M et al.. Phosphorylation of NFATC1 at PIM1 target sites is essential for its ability to promote prostate cancer cell migration and invasion. Cell Commun Signal. 2019;17 (1):148. doi: 10.1186/s12964-019-0463-y. PubMed PMID:31730483 PubMed Central PMC6858710.
2. Booth, N, Rissanen, P, Tammela, TLJ, Kujala, P, Stenman, UH, Taari, K et al.. Cost-effectiveness analysis of PSA-based mass screening: Evidence from a randomised controlled trial combined with register data. PLoS One. 2019;14 (11):e0224479. doi: 10.1371/journal.pone.0224479. PubMed PMID:31689326 PubMed Central PMC6830755.
3. Granberg, KJ, Raita, A, Lehtinen, B, Tiihonen, AM, Kesseli, J, Annala, M et al.. Moderate-to-strong expression of FGFR3 and TP53 alterations in a subpopulation of choroid plexus tumors. Histol Histopathol. 2020;35 (7):673-680. doi: 10.14670/HH-18-180. PubMed PMID:31660579 .
4. Santala, EEE, Kotsar, A, Veitonmäki, T, Tammela, TLJ, Murtola, TJ. Risk of urothelial cancer death among people using antihypertensive drugs-a cohort study from Finland. Scand J Urol. 2019;53 (4):185-192. doi: 10.1080/21681805.2019.1634147. PubMed PMID:31250699 .
5. Kinnunen, PTT, Murtola, TJ, Talala, K, Taari, K, Tammela, TLJ, Auvinen, A et al.. Anticoagulants and cancer mortality in the Finnish randomized study of screening for prostate cancer. Cancer Causes Control. 2019;30 (8):877-888. doi: 10.1007/s10552-019-01195-x. PubMed PMID:31209595 .
6. Carlsson, SV, Månsson, M, Moss, S, Kwiatkowski, M, Recker, F, Tammela, TLJ et al.. Could Differences in Treatment Between Trial Arms Explain the Reduction in Prostate Cancer Mortality in the European Randomized Study of Screening for Prostate Cancer?. Eur Urol. 2019;75 (6):1015-1022. doi: 10.1016/j.eururo.2019.03.010. PubMed PMID:30928162 PubMed Central PMC7526685.
7. Hugosson, J, Roobol, MJ, Månsson, M, Tammela, TLJ, Zappa, M, Nelen, V et al.. A 16-yr Follow-up of the European Randomized study of Screening for Prostate Cancer. Eur Urol. 2019;76 (1):43-51. doi: 10.1016/j.eururo.2019.02.009. PubMed PMID:30824296 PubMed Central PMC7513694.
8. Kukko, V, Kaipia, A, Talala, K, Taari, K, Tammela, TLJ, Auvinen, A et al.. Allopurinol and the risk of prostate cancer in a Finnish population-based cohort. Prostate Cancer Prostatic Dis. 2019;22 (3):483-490. doi: 10.1038/s41391-019-0129-2. PubMed PMID:30696944 .
9. Murtola, TJ, Sälli, SM, Talala, K, Taari, K, Tammela, TLJ, Auvinen, A et al.. Blood glucose, glucose balance, and disease-specific survival after prostate cancer diagnosis in the Finnish Randomized Study of Screening for Prostate Cancer. Prostate Cancer Prostatic Dis. 2019;22 (3):453-460. doi: 10.1038/s41391-018-0123-0. PubMed PMID:30679762 .
10. Matejcic, M, Saunders, EJ, Dadaev, T, Brook, MN, Wang, K, Sheng, X et al.. Author Correction: Germline variation at 8q24 and prostate cancer risk in men of European ancestry. Nat Commun. 2019;10 (1):382. doi: 10.1038/s41467-019-08293-z. PubMed PMID:30655571 PubMed Central PMC6336778.
11. Schumacher, FR, Olama, AAA, Berndt, SI, Benlloch, S, Ahmed, M, Saunders, EJ et al.. Author Correction: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. Nat Genet. 2019;51 (2):363. doi: 10.1038/s41588-018-0330-6. PubMed PMID:30622367 .
12. Åkerla, J, Pesonen, JS, Pöyhönen, A, Häkkinen, J, Koskimäki, J, Huhtala, H et al.. Impact of lower urinary tract symptoms on mortality: a 21-year follow-up among middle-aged and elderly Finnish men. Prostate Cancer Prostatic Dis. 2019;22 (2):317-323. doi: 10.1038/s41391-018-0108-z. PubMed PMID:30410016 .
13. Li-Sheng Chen, S, Ching-Yuan Fann, J, Sipeky, C, Yang, TK, Yueh-Hsia Chiu, S, Ming-Fang Yen, A et al.. Risk Prediction of Prostate Cancer with Single Nucleotide Polymorphisms and Prostate Specific Antigen. J Urol. 2019;201 (3):486-495. doi: 10.1016/j.juro.2018.10.015. PubMed PMID:30366021 .
14. Pakarainen, T, Nevalainen, J, Talala, K, Taari, K, Raitanen, J, Kujala, P et al.. The Number of Screening Cycles Needed to Reduce Prostate Cancer Mortality in the Finnish Section of the European Randomized Study of Prostate Cancer (ERSPC). Clin Cancer Res. 2019;25 (2):839-843. doi: 10.1158/1078-0432.CCR-18-1807. PubMed PMID:30322875 .
15. Murtola, TJ, Kasurinen, TVJ, Talala, K, Taari, K, Tammela, TLJ, Auvinen, A et al.. Serum cholesterol and prostate cancer risk in the Finnish randomized study of screening for prostate cancer. Prostate Cancer Prostatic Dis. 2019;22 (1):66-76. doi: 10.1038/s41391-018-0087-0. PubMed PMID:30214034 .
16. Assel, M, Sjöblom, L, Murtola, TJ, Talala, K, Kujala, P, Stenman, UH et al.. A Four-kallikrein Panel and β-Microseminoprotein in Predicting High-grade Prostate Cancer on Biopsy: An Independent Replication from the Finnish Section of the European Randomized Study of Screening for Prostate Cancer. Eur Urol Focus. 2019;5 (4):561-567. doi: 10.1016/j.euf.2017.11.002. PubMed PMID:29137895 PubMed Central PMC5948115.

Search PubMed

1. Siltari, A, Murtola, TJ, Talala, K, Taari, K, Tammela, TLJ, Auvinen, A et al.. Antihypertensive drugs and prostate cancer risk in a Finnish population-based cohort. Scand J Urol. 2018;52 (5-6):321-327. doi: 10.1080/21681805.2018.1559882. PubMed PMID:30698056 .
2. Schiewer, MJ, Mandigo, AC, Gordon, N, Huang, F, Gaur, S, de Leeuw, R et al.. PARP-1 regulates DNA repair factor availability. EMBO Mol Med. 2018;10 (12):. doi: 10.15252/emmm.201708816. PubMed PMID:30467127 PubMed Central PMC6284389.
3. Åkerla, J, Pesonen, JS, Pöyhönen, A, Häkkinen, J, Koskimäki, J, Huhtala, H et al.. Impact of lower urinary tract symptoms on mortality: a 21-year follow-up among middle-aged and elderly Finnish men. Prostate Cancer Prostatic Dis. 2019;22 (2):317-323. doi: 10.1038/s41391-018-0108-z. PubMed PMID:30410016 .
4. Matejcic, M, Saunders, EJ, Dadaev, T, Brook, MN, Wang, K, Sheng, X et al.. Germline variation at 8q24 and prostate cancer risk in men of European ancestry. Nat Commun. 2018;9 (1):4616. doi: 10.1038/s41467-018-06863-1. PubMed PMID:30397198 PubMed Central PMC6218483.
5. Pöyhönen, A, Åkerla, J, Häkkinen, JT, Koskimäki, J, Tammela, TLJ, Auvinen, A et al.. Severity and bother of lower urinary tract symptoms among men aged 30-80 years: Tampere Ageing Male Urological Study (TAMUS). Scand J Urol. 2018;52 (4):296-301. doi: 10.1080/21681805.2018.1505944. PubMed PMID:30382800 .
6. Rantaniemi, L, Tammela, TLJ, Kujala, P, Murtola, TJ. Blood cholesterol, tumor clinical characteristics and risk of prostate cancer progression after radical prostatectomy. Scand J Urol. 2018;52 (4):269-276. doi: 10.1080/21681805.2018.1492967. PubMed PMID:30362865 .
7. Pakarainen, T, Nevalainen, J, Talala, K, Taari, K, Raitanen, J, Kujala, P et al.. The Number of Screening Cycles Needed to Reduce Prostate Cancer Mortality in the Finnish Section of the European Randomized Study of Prostate Cancer (ERSPC). Clin Cancer Res. 2019;25 (2):839-843. doi: 10.1158/1078-0432.CCR-18-1807. PubMed PMID:30322875 .
8. Latonen, L, Nykter, M, Visakorpi, T. Proteomics of prostate cancer – revealing how cancer cells master their messy genomes. Oncoscience. 2018;5 (7-8):216-217. doi: 10.18632/oncoscience.453. PubMed PMID:30234142 PubMed Central PMC6142899.
9. Murtola, TJ, Kasurinen, TVJ, Talala, K, Taari, K, Tammela, TLJ, Auvinen, A et al.. Serum cholesterol and prostate cancer risk in the Finnish randomized study of screening for prostate cancer. Prostate Cancer Prostatic Dis. 2019;22 (1):66-76. doi: 10.1038/s41391-018-0087-0. PubMed PMID:30214034 .
10. Sipeky, C, Gao, P, Zhang, Q, Wang, L, Ettala, O, Talala, KM et al.. Synergistic Interaction of and Predisposes to Aggressive Prostate Cancer. Clin Cancer Res. 2018;24 (24):6265-6276. doi: 10.1158/1078-0432.CCR-18-0444. PubMed PMID:30181389 PubMed Central PMC6719560.
11. Veskimäe, K, Scaravilli, M, Niininen, W, Karvonen, H, Jaatinen, S, Nykter, M et al.. Expression Analysis of Platinum Sensitive and Resistant Epithelial Ovarian Cancer Patient Samples Reveals New Candidates for Targeted Therapies. Transl Oncol. 2018;11 (5):1160-1170. doi: 10.1016/j.tranon.2018.07.010. PubMed PMID:30056367 PubMed Central PMC6079561.
12. Gao, P, Xia, JH, Sipeky, C, Dong, XM, Zhang, Q, Yang, Y et al.. Biology and Clinical Implications of the 19q13 Aggressive Prostate Cancer Susceptibility Locus. Cell. 2018;174 (3):576-589.e18. doi: 10.1016/j.cell.2018.06.003. PubMed PMID:30033361 PubMed Central PMC6091222.
13. Murtola, TJ, Syvälä, H, Tolonen, T, Helminen, M, Riikonen, J, Koskimäki, J et al.. Atorvastatin Versus Placebo for Prostate Cancer Before Radical Prostatectomy-A Randomized, Double-blind, Placebo-controlled Clinical Trial. Eur Urol. 2018;74 (6):697-701. doi: 10.1016/j.eururo.2018.06.037. PubMed PMID:30031572 .
14. Kallio, HML, Hieta, R, Latonen, L, Brofeldt, A, Annala, M, Kivinummi, K et al.. Constitutively active androgen receptor splice variants AR-V3, AR-V7 and AR-V9 are co-expressed in castration-resistant prostate cancer metastases. Br J Cancer. 2018;119 (3):347-356. doi: 10.1038/s41416-018-0172-0. PubMed PMID:29988112 PubMed Central PMC6070921.
15. Kaapu, KJ, Rantaniemi, L, Talala, K, Taari, K, Tammela, TLJ, Auvinen, A et al.. Cancer mortality does not differ by antiarrhythmic drug use: A population-based cohort of Finnish men. Sci Rep. 2018;8 (1):10308. doi: 10.1038/s41598-018-28541-4. PubMed PMID:29985440 PubMed Central PMC6037774.
16. Dadaev, T, Saunders, EJ, Newcombe, PJ, Anokian, E, Leongamornlert, DA, Brook, MN et al.. Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants. Nat Commun. 2018;9 (1):2256. doi: 10.1038/s41467-018-04109-8. PubMed PMID:29892050 PubMed Central PMC5995836.
17. Schumacher, FR, Al Olama, AA, Berndt, SI, Benlloch, S, Ahmed, M, Saunders, EJ et al.. Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. Nat Genet. 2018;50 (7):928-936. doi: 10.1038/s41588-018-0142-8. PubMed PMID:29892016 PubMed Central PMC6568012.
18. Tolonen, TT, Riikonen, J, Tammela, TLJ, Koivusalo, L, Haapasalo, H, Kujala, P et al.. Extraprostatic extension (pT3a) in prostate biopsy is an under-recognized feature indicating high risk disease. Ann Diagn Pathol. 2018;35 :80-84. doi: 10.1016/j.anndiagpath.2018.06.001. PubMed PMID:29886397 .
19. Mäkelä, VJ, Kotsar, A, Tammela, TLJ, Murtola, TJ. Bladder Cancer Survival of Men Receiving 5α-Reductase Inhibitors. J Urol. 2018;200 (4):743-748. doi: 10.1016/j.juro.2018.04.082. PubMed PMID:29730200 .
20. Sainio, M, Visakorpi, T, Tolonen, T, Ilvesaro, J, Bova, GS. Expression of neuroendocrine differentiation markers in lethal metastatic castration-resistant prostate cancer. Pathol Res Pract. 2018;214 (6):848-856. doi: 10.1016/j.prp.2018.04.015. PubMed PMID:29728311 .
21. Kartasalo, K, Latonen, L, Vihinen, J, Visakorpi, T, Nykter, M, Ruusuvuori, P et al.. Comparative analysis of tissue reconstruction algorithms for 3D histology. Bioinformatics. 2018;34 (17):3013-3021. doi: 10.1093/bioinformatics/bty210. PubMed PMID:29684099 PubMed Central PMC6129300.
22. Wedge, DC, Gundem, G, Mitchell, T, Woodcock, DJ, Martincorena, I, Ghori, M et al.. Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets. Nat Genet. 2018;50 (5):682-692. doi: 10.1038/s41588-018-0086-z. PubMed PMID:29662167 PubMed Central PMC6372064.
23. Latonen, L, Afyounian, E, Jylhä, A, Nättinen, J, Aapola, U, Annala, M et al.. Integrative proteomics in prostate cancer uncovers robustness against genomic and transcriptomic aberrations during disease progression. Nat Commun. 2018;9 (1):1176. doi: 10.1038/s41467-018-03573-6. PubMed PMID:29563510 PubMed Central PMC5862881.
24. Booth, N, Rissanen, P, Tammela, TLJ, Taari, K, Talala, K, Auvinen, A et al.. Costs of screening for prostate cancer: Evidence from the Finnish Randomised Study of Screening for Prostate Cancer after 20-year follow-up using register data. Eur J Cancer. 2018;93 :108-118. doi: 10.1016/j.ejca.2018.01.111. PubMed PMID:29501976 .
25. Claessens, F, Visakorpi, T. Endocrinology of prostate cancer. Mol Cell Endocrinol. 2018;462 (Pt A):1-2. doi: 10.1016/j.mce.2018.01.005. PubMed PMID:29463415 .
26. Ahlgren, GM, Flodgren, P, Tammela, TLJ, Kellokumpu-Lehtinen, P, Borre, M, Angelsen, A et al.. Docetaxel Versus Surveillance After Radical Prostatectomy for High-risk Prostate Cancer: Results from the Prospective Randomised, Open-label Phase 3 Scandinavian Prostate Cancer Group 12 Trial. Eur Urol. 2018;73 (6):870-876. doi: 10.1016/j.eururo.2018.01.012. PubMed PMID:29395502 .
27. Kukko, V, Kaipia, A, Talala, K, Taari, K, Tammela, TLJ, Auvinen, A et al.. Allopurinol and risk of benign prostatic hyperplasia in a Finnish population-based cohort. Prostate Cancer Prostatic Dis. 2018;21 (3):373-378. doi: 10.1038/s41391-017-0031-8. PubMed PMID:29273728 .
28. McNair, C, Xu, K, Mandigo, AC, Benelli, M, Leiby, B, Rodrigues, D et al.. Differential impact of RB status on E2F1 reprogramming in human cancer. J Clin Invest. 2018;128 (1):341-358. doi: 10.1172/JCI93566. PubMed PMID:29202480 PubMed Central PMC5749518.
29. Högnäs, G, Kivinummi, K, Kallio, HML, Hieta, R, Ruusuvuori, P, Koskenalho, A et al.. Feasibility of Prostate PAXgene Fixation for Molecular Research and Diagnostic Surgical Pathology: Comparison of Matched Fresh Frozen, FFPE, and PFPE Tissues. Am J Surg Pathol. 2018;42 (1):103-115. doi: 10.1097/PAS.0000000000000961. PubMed PMID:28984675 .
30. Murtola, TJ, Vettenranta, AM, Talala, K, Taari, K, Stenman, UH, Tammela, TLJ et al.. Outcomes of Prostate-specific Antigen-based Prostate Cancer Screening Among Men Using Nonsteroidal Anti-inflammatory Drugs. Eur Urol Focus. 2018;4 (6):851-857. doi: 10.1016/j.euf.2017.03.005. PubMed PMID:28753870 .

Search PubMed