Publications | Protein Nanosystems | Tampere Universities

19.8.2026

Modular plug-and-play crosslinking platform for precision-engineered hydrogels

Evans, A., Parvathaneni, R. P., Rahikainen, R., Varghese, O. P., Hytönen, V. & Podiyan Oommen, O., 19 Aug 2026, In: Cell Reports Physical Science. 7, 8, 103457.

Research output: Contribution to journal › Article › Scientific › peer-review

1.9.2025

De novo talin-1 variant L353F connects multifaceted clinical symptoms to alterations in talin-1 function

Athale, M., Ball, N., Azizi, L., Valenzuela, I., Codina, M., Martin-Nalda, A., Mykuliak, V. V., Rahikainen, R., Goult, B. T., Turkki, P. & Hytönen, V. P., Sept 2025, In: Biochemical Journal. 482, 18, p. 1337-1352 16 p.

Research output: Contribution to journal › Article › Scientific › peer-review

1.8.2024

Molecular dynamics simulations reveal how vinculin refolds partially unfolded talin rod helices to stabilize them against mechanical force

Mykuliak, V. V., Rahikainen, R., Ball, N. J., Bussi, G., Goult, B. T. & Hytönen, V. P., Aug 2024, In: PLoS Computational Biology. 20, 8, e1012341.

Research output: Contribution to journal › Article › Scientific › peer-review

15.11.2023

Visible Light-Induced Specific Protein Reaction Delineates Early Stages of Cell Adhesion

Rahikainen, R., Vester, S. K., Turkki, P., Janosko, C. P., Deiters, A., Hytönen, V. P. & Howarth, M., 15 Nov 2023, In: Journal of the American Chemical Society. 145, 45, p. 24459–24465

Research output: Contribution to journal › Article › Scientific › peer-review

1.4.2023

ConFERMing the role of talin in integrin activation and mechanosignaling

Bachmann, M., Su, B., Rahikainen, R., Hytönen, V. P., Wu, J. & Wehrle-Haller, B., Apr 2023, In: Journal of Cell Science. 136, 8, 11 p., jcs260576.

Research output: Contribution to journal › Review Article › peer-review

1.12.2022

SpySwitch enables pH- or heat-responsive capture and release for plug-and-display nanoassembly

Vester, S. K., Rahikainen, R., Khairil Anuar, I. N. A., Hills, R. A., Tan, T. K. & Howarth, M., Dec 2022, In: Nature Communications. 13, 1, 3714.

Research output: Contribution to journal › Article › Scientific › peer-review

1.1.2021

Surface Modification of Bioresorbable Phosphate Glasses for Controlled Protein Adsorption

Huynh, N. B., Palma, C. S. D., Rahikainen, R., Mishra, A., Azizi, L., Verne, E., Ferraris, S., Hytönen, V. P., Sanches Ribeiro, A. & Massera, J., 2021, In: ACS Biomaterials Science and Engineering. 7, 9, p. 4483−4493

Research output: Contribution to journal › Article › Scientific › peer-review

12.10.2020

The F1 loop of the talin head domain acts as a gatekeeper in integrin activation and clustering

Kukkurainen, S., Azizi, L., Zhang, P., Jacquier, M. C., Baikoghli, M., von Essen, M., Tuukkanen, A., Laitaoja, M., Liu, X., Rahikainen, R., Orłowski, A., Jänis, J., Määttä, J. A. E., Varjosalo, M., Vattulainen, I., Róg, T., Svergun, D., Cheng, R. H., Wu, J. & Hytönen, V. P. & 1 others, Wehrle-Haller, B., 12 Oct 2020, In: Journal of Cell Science. 133, 19

Research output: Contribution to journal › Article › Scientific › peer-review

1.1.2019

Talin-mediated force transmission and talin rod domain unfolding independently regulate adhesion signaling

Rahikainen, R., Öhman, T., Turkki, P., Varjosalo, M. & Hytönen, V. P., 2019, In: Journal of Cell Science. 132, 7, p. 226514 jcs226514.

Research output: Contribution to journal › Article › Scientific › peer-review

1.1.2019

Approaching infinite affinity through engineering of peptide-protein interaction

Keeble, A. H., Turkki, P., Stokes, S., Anuar, I., Rahikainen, R., Hytönen, V. P. & Howarth, M., 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 52, p. 26523-26533

Research output: Contribution to journal › Article › Scientific › peer-review

1.1.2018

Mechanotransduction in talin through the interaction of the R8 domain with DLC1

Haining, A. W. M., Rahikainen, R., Cortes, E., Lachowski, D., Rice, A., von Essen, M., ESSEN, V. M., Hytönen, V. P., Hernandez, A. D. R. & Del RÍO Hernández, A., 2018, In: PLoS Biology. 16, 7, p. e2005599 e2005599.

Research output: Contribution to journal › Article › Scientific › peer-review

1.1.2018

Talin mechanosensing in the regulation of adhesion complex composition and function

Rahikainen, R., 2018, Tampere: Tampere University Press. (Acta Electronica Universitatis Tamperensis; no. 1940)

Research output: Book/Report › Doctoral thesis › Collection of Articles

1.1.2017

Mixture of PLA-PEG and biotinylated albumin enables immobilization of avidins on electrospun fibers

Manish, K., Kumar, M., Rahikainen, R., Unruh, D., Uhruh, D., Hytönen, V. P., Delbrück, C., Sindelar, R. & Renz, F., 2017, In: Journal of Biomedical Materials Research - Part A. 105A, 2, p. 357

Research output: Contribution to journal › Article › Scientific › peer-review

1.1.2017

Mechanical stability of talin rod controls cell migration and substrate sensing

Rahikainen, R., von Essen, M., Schaefer, M., Qi, L., Azizi, L., Conor, K., Kelly, C., Ihalainen, T. O., Wehrle-Haller, B., Martin, B., Bastmeyer, M., Cai, H., Huang, C. & Hytönen, V. P., 2017, In: Scientific Reports. 7, 1, p. 3571 3571.

Research output: Contribution to journal › Article › Scientific › peer-review

1.1.2017

Synergistic Expression of Histone Deacetylase 9 and Matrix Metalloproteinase 12 in M4 Macrophages in Advanced Carotid Plaques

Oksala, N., Seppälä, I., Rahikainen, R., Mäkelä, K., Raitoharju, E., Illig, T., Klopp, N., Kholova, I., Laaksonen, R., Karhunen, P., Hytönen, V. & Lehtimäki, T., 2017, In: European Journal of Vascular and Endovascular Surgery. 53, 5, p. 632-640

Research output: Contribution to journal › Article › Scientific › peer-review

1.1.2017

Pneumatically actuated elastomeric device for simultaneous mechanobiological studies & live-cell fluorescent microscopy

Kreutzer, J., Viehrig, M., Maki, A.-J., Kallio, P., Rahikainen, R. & Hytönen, V., 2017, International Conference on Manipulation, Automation and Robotics at Small Scales, MARSS 2017 - Proceedings. Haliyo, S., Martel, S. & Fatikow, S. (eds.). IEEE

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Scientific › peer-review

1.8.2016

Cell Stretching Device for Live-Cell Confocal Microscopy

Kreutzer, J., Viehrig, M., Rahikainen, R., Mäki, A., Hytönen, V. P. & Kallio, P., Aug 2016, 2016 IEEE 38th Annual International Conference of the Engineering in Medicine and Biology Society (EMBC). 1 p. (Annual International Conference of the Engineering in Medicine and Biology Society (EMBC)).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Scientific

1.1.2016

Talin and vinculin are downregulated in atherosclerotic plaque : Tampere Vascular Study

von Essen, M., Rahikainen, R., Oksala, N., Raitoharju, E., Seppälä, I., Mennander, A., Sioris, T., Kholová, I., Klopp, N., Illig, T., Karhunen, P., Kähönen, M., Lehtimäki, T. & Hytönen, V., 2016, In: Atherosclerosis. 255, p. 43-53

Research output: Contribution to journal › Article › Scientific › peer-review

1.1.2015

His-tagged norovirus-like particles: A versatile platform for cellular delivery and surface display

Koho, T., Ihalainen, T. O., Stark, M., Uusi-Kerttula, H., Wieneke, R., Rahikainen, R., Blazevic, V., Marjomäki, V., Tampé, R., Kulomaa, M. S. & Hytönen, V. P., 2015, In: European Journal of Pharmaceutics and Biopharmaceutics. 96, 1, p. 22-31 10 p.

Research output: Contribution to journal › Article › Scientific › peer-review

1.1.2015

Enhancement of adhesion and promotion of osteogenic differentiation of human adipose stem cells by poled electroactive poly(vinylidene fluoride)

Parssinen, J., Hammarén, H., Rahikainen, R., Sencadas, V., Ribeiro, C., Vanhatupa, S., Miettinen, S., Lanceros-Méndez, S. & Hytönen, V. P., 2015, In: Journal of Biomedical Materials Research - Part A. 103, 3, p. 919-928 10 p.

Research output: Contribution to journal › Article › Scientific › peer-review

1.1.2015

Efficient preparation of shuffled DNA libraries through recombination (Gateway) cloning

Lehtonen, S. I., Taskinen, B., Ojala, E., Kukkurainen, S., Rahikainen, R., Riihimäki, T. A., Laitinen, O. H., Kulomaa, M. S. & Hytönen, V. P., 2015, In: Protein Engineering, Design and Selection. 28, 1, p. 23-28 6 p.

Research output: Contribution to journal › Article › Scientific › peer-review

1.1.2014

A novel chimeric avidin with increased thermal stability using DNA shuffling

Taskinen, B., Airenne, T. T., Jänis, J., Rahikainen, R., Johnson, M. S., Kulomaa, M. S. & Hytönen, V. P., 2014, In: PLoS ONE. 9, 3, p. e92058 e92058.

Research output: Contribution to journal › Article › Scientific › peer-review

1.1.2014

Talin-bound NPLY motif recruits integrin-signaling adapters to regulate cell spreading and mechanosensing

Pinon, P., Pärssinen, J., Vazquez, P., Bachmann, M., Rahikainen, R., Jacquier, M. C., Azizi, L., Määttä, J. A., Bastmeyer, M., Hytönen, V. P. & Wehrle-Haller, B., 2014, In: Journal of Cell Biology. 205, 2, p. 265-281 17 p.

Research output: Contribution to journal › Article › Scientific › peer-review

1.1.2012

New and robust avidins: Insight into the use of versatile and robust molecular tools

Rahikainen, R., Hiltunen, S., Hytönen, V. & Kulomaa, M., 2012, Advances in Developing Affordable In Vitro Molecular Diagnostics. Puri, C., Abidi, N., Bhanushali, P., Pere, A. & Satish, G. (eds.). Navi Mumbai, India: Yashraj Research Foundation, p. 99-110

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Scientific

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