Skip to content
Virology

Led by Professor Heikki Hyöty

Publications

2024

  1. Hyöty, H, Laiho, JE, Virtanen, SM. Environmental Factors in Type 1 Diabetes. Cold Spring Harb Perspect Med. 2024; :. doi: 10.1101/cshperspect.a041590. PubMed PMID:39586629 .
  2. Lernmark, Å, Agardh, D, Akolkar, B, Gesualdo, P, Hagopian, WA, Haller, MJ et al.. Looking back at the TEDDY study: lessons and future directions. Nat Rev Endocrinol. 2024; :. doi: 10.1038/s41574-024-01045-0. PubMed PMID:39496810 .
  3. Eurén, A, Lynch, K, Lindfors, K, Parikh, H, Koletzko, S, Liu, E et al.. Risk of celiac disease autoimmunity is modified by interactions between CD247 and environmental exposures. Sci Rep. 2024;14 (1):25463. doi: 10.1038/s41598-024-75496-w. PubMed PMID:39462122 PubMed Central PMC11567144.
  4. Laiho, JE, Oikarinen, S, Morfopoulou, S, Oikarinen, M, Renner, A, Depledge, D et al.. Detection of enterovirus RNA in pancreas and lymphoid tissues of organ donors with type 1 diabetes. medRxiv. 2024; :. doi: 10.1101/2024.09.11.24313112. PubMed PMID:39314969 PubMed Central PMC11419248.
  5. Parajuli, A, Mäkelä, I, Roslund, MI, Ringqvist, E, Manninen, J, Sun, Y et al.. Production, analysis, and safety assessment of a soil and plant-based natural material with microbiome- and immune-modulatory effects. Methods. 2024;231 :94-102. doi: 10.1016/j.ymeth.2024.09.011. PubMed PMID:39306218 .
  6. Ojwang’, V, Nwaru, BI, Hanna-Mari, T, Heli, T, Kaila, M, Ahonen, S et al.. Early-pregnancy BMI, maternal gestational weight gain, and asthma and allergic diseases in children. Pediatr Allergy Immunol. 2024;35 (9):e14240. doi: 10.1111/pai.14240. PubMed PMID:39282918 .
  7. Grönroos, M, Jumpponen, A, Roslund, MI, Nurminen, N, Oikarinen, S, Parajuli, A et al.. Using patterns of shared taxa to infer bacterial dispersal in human living environment in urban and rural areas. Appl Environ Microbiol. 2024;90 (10):e0090324. doi: 10.1128/aem.00903-24. PubMed PMID:39230286 PubMed Central PMC11498140.
  8. Roslund, MI, Nurminen, N, Oikarinen, S, Puhakka, R, Grönroos, M, Puustinen, L et al.. Skin exposure to soil microbiota elicits changes in cell-mediated immunity to pneumococcal vaccine. Sci Rep. 2024;14 (1):18573. doi: 10.1038/s41598-024-68235-8. PubMed PMID:39127736 PubMed Central PMC11316737.
  9. Jonsdottir, B, Clasen, JL, Vehik, K, Lernmark, Å, Lundgren, M, Bonifacio, E et al.. Early appearance of thyroid autoimmunity in children followed from birth for type 1 diabetes risk. J Clin Endocrinol Metab. 2024; :. doi: 10.1210/clinem/dgae478. PubMed PMID:38996042 .
  10. Niinistö, S, Cuthbertson, D, Miettinen, ME, Hakola, L, Nucci, A, Korhonen, TE et al.. High Concentrations of Immunoglobulin G Against Cow Milk Proteins and Frequency of Cow Milk Consumption Are Associated With the Development of Islet Autoimmunity and Type 1 Diabetes-The Trial to Reduce Insulin-dependent Diabetes Mellitus (IDDM) in the Genetically at Risk (TRIGR) Study. J Nutr. 2024;154 (8):2493-2500. doi: 10.1016/j.tjnut.2024.06.005. PubMed PMID:38906178 PubMed Central PMC11375457.
  11. Hakola, L, Lund-Blix, NA, Takkinen, HM, Tapanainen, H, Niinistö, S, Korhonen, TE et al.. Maternal gluten, cereal, and dietary fiber intake during pregnancy and lactation and the risk of islet autoimmunity and type 1 diabetes in the child. Clin Nutr ESPEN. 2024;62 :22-27. doi: 10.1016/j.clnesp.2024.05.001. PubMed PMID:38901945 .
  12. Salo, TE, Hakola, L, Niinistö, S, Takkinen, HM, Ahonen, S, Puustinen, L et al.. Gut Inflammation Markers, Diet, and Risk of Islet Autoimmunity in Finnish Children – A Nested Case-Control Study. J Nutr. 2024;154 (7):2244-2254. doi: 10.1016/j.tjnut.2024.05.015. PubMed PMID:38795745 PubMed Central PMC11282497.
  13. Starskaia, I, Valta, M, Pietilä, S, Suomi, T, Pahkuri, S, Kalim, UU et al.. Distinct cellular immune responses in children en route to type 1 diabetes with different first-appearing autoantibodies. Nat Commun. 2024;15 (1):3810. doi: 10.1038/s41467-024-47918-w. PubMed PMID:38714671 PubMed Central PMC11076468.
  14. Saarenpää, M, Roslund, MI, Nurminen, N, Puhakka, R, Kummola, L, Laitinen, OH et al.. Urban indoor gardening enhances immune regulation and diversifies skin microbiota – A placebo-controlled double-blinded intervention study. Environ Int. 2024;187 :108705. doi: 10.1016/j.envint.2024.108705. PubMed PMID:38688234 .
  15. Meinhardt, A, Reilly, L, Kaliakatsos, M, Abdel-Aziz, K, Alsharidah, S, Bodi, I et al.. Novel antivirals for severe enterovirus infection in immunocompromised hosts; A case series. J Infect. 2024;88 (5):106142. doi: 10.1016/j.jinf.2024.106142. PubMed PMID:38527653 .
  16. Vecchio, F, Carré, A, Korenkov, D, Zhou, Z, Apaolaza, P, Tuomela, S et al.. Coxsackievirus infection induces direct pancreatic β cell killing but poor antiviral CD8 T cell responses. Sci Adv. 2024;10 (10):eadl1122. doi: 10.1126/sciadv.adl1122. PubMed PMID:38446892 PubMed Central PMC10917340.
  17. Hakola, L, Mramba, LK, Uusitalo, U, Andrén Aronsson, C, Hummel, S, Niinistö, S et al.. Intake of B vitamins and the risk of developing islet autoimmunity and type 1 diabetes in the TEDDY study. Eur J Nutr. 2024;63 (4):1329-1338. doi: 10.1007/s00394-024-03346-6. PubMed PMID:38413484 PubMed Central PMC11139689.
  18. Hyöty, H, Kääriäinen, S, Laiho, JE, Comer, GM, Tian, W, Härkönen, T et al.. Safety, tolerability and immunogenicity of PRV-101, a multivalent vaccine targeting coxsackie B viruses (CVBs) associated with type 1 diabetes: a double-blind randomised placebo-controlled Phase I trial. Diabetologia. 2024;67 (5):811-821. doi: 10.1007/s00125-024-06092-w. PubMed PMID:38369573 PubMed Central PMC10954874.

Search PubMed

2023
  1. Nigi, L, Laiho, JE, Hyöty, H, Dotta, F. Editorial: The contribution of viruses and innate immune system in the pathogenesis of type 1 diabetes. Front Endocrinol (Lausanne). 2023;14 :1335716. doi: 10.3389/fendo.2023.1335716. PubMed PMID:38161972 PubMed Central PMC10757338.
  2. Nygård, L, Valta, M, Laine, AP, Toppari, J, Knip, M, Veijola, R et al.. CXADR polymorphism rs6517774 modifies islet autoimmunity characteristics and exhibits sex disparity. Front Genet. 2023;14 :1248701. doi: 10.3389/fgene.2023.1248701. PubMed PMID:38028613 PubMed Central PMC10651746.
  3. Lin, J, Moradi, E, Salenius, K, Lehtipuro, S, Häkkinen, T, Laiho, JE et al.. Distinct transcriptomic profiles in children prior to the appearance of type 1 diabetes-linked islet autoantibodies and following enterovirus infection. Nat Commun. 2023;14 (1):7630. doi: 10.1038/s41467-023-42763-9. PubMed PMID:37993433PubMed Central PMC10665402.
  4. Krogvold, L, Mynarek, IM, Ponzi, E, Mørk, FB, Hessel, TW, Roald, T et al.. Pleconaril and ribavirin in new-onset type 1 diabetes: a phase 2 randomized trial. Nat Med. 2023;29 (11):2902-2908. doi: 10.1038/s41591-023-02576-1. PubMed PMID:37789144 PubMed Central PMC10667091.
  5. Lamichhane, S, Sen, P, Dickens, AM, Kråkström, M, Ilonen, J, Lempainen, J et al.. Circulating metabolic signatures of rapid and slow progression to type 1 diabetes in islet autoantibody-positive children. Front Endocrinol (Lausanne). 2023;14 :1211015. doi: 10.3389/fendo.2023.1211015. PubMed PMID:37745723 PubMed Central PMC10516565.
  6. Hirvonen, MK, Lietzén, N, Moulder, R, Bhosale, SD, Koskenniemi, J, Vähä-Mäkilä, M et al.. Serum APOC1 levels are decreased in young autoantibody positive children who rapidly progress to type 1 diabetes. Sci Rep. 2023;13 (1):15941. doi: 10.1038/s41598-023-43039-4. PubMed PMID:37743383 PubMed Central PMC10518308.
  7. Wicaksono, WA, Cernava, T, Wassermann, B, Abdelfattah, A, Soto-Giron, MJ, Toledo, GV et al.. The edible plant microbiome: evidence for the occurrence of fruit and vegetable bacteria in the human gut. Gut Microbes. 2023;15 (2):2258565. doi: 10.1080/19490976.2023.2258565. PubMed PMID:37741805PubMed Central PMC10519362.
  8. Kummola, L, González-Rodríguez, MI, Marnila, P, Nurminen, N, Salomaa, T, Hiihtola, L et al.. Comparison of the effect of autoclaved and non-autoclaved live soil exposure on the mouse immune system : Effect of soil exposure on immune system. BMC Immunol. 2023;24 (1):29. doi: 10.1186/s12865-023-00565-0. PubMed PMID:37689649 PubMed Central PMC10492337.
  9. Vecchio, F, Carré, A, Korenkov, D, Zhou, Z, Apaolaza, P, Tuomela, S et al.. Coxsackievirus infection induces direct pancreatic β-cell killing but poor anti-viral CD8+ T-cell responses. bioRxiv. 2023; :. doi: 10.1101/2023.08.19.553954. PubMed PMID:37662376 PubMed Central PMC10473604.
  10. Dotsenko, V, Sioofy-Khojine, AB, Hyöty, H, Viiri, K. Human intestinal organoid models for celiac disease research. Methods Cell Biol. 2023;179 :173-193. doi: 10.1016/bs.mcb.2023.01.008. PubMed PMID:37625874 .
  11. Lönnrot, M, Lynch, KF, Rewers, M, Lernmark, Å, Vehik, K, Akolkar, B et al.. Gastrointestinal Infections Modulate the Risk for Insulin Autoantibodies as the First-Appearing Autoantibody in the TEDDY Study. Diabetes Care. 2023;46 (11):1908-1915. doi: 10.2337/dc23-0518. PubMed PMID:37607456 PubMed Central PMC10620548.
  12. Uusitalo, U, Mramba, LK, Aronsson, CA, Vehik, K, Yang, J, Hummel, S et al.. HLA Genotype and Probiotics Modify the Association Between Timing of Solid Food Introduction and Islet Autoimmunity in the TEDDY Study. Diabetes Care. 2023;46 (10):1839-1847. doi: 10.2337/dc23-0417. PubMed PMID:37579501PubMed Central PMC10516243.
  13. Krischer, JP, Lernmark, Å, Hagopian, WA, Rewers, MJ, McIndoe, R, Toppari, J et al.. SARS-CoV-2 – No Increased Islet Autoimmunity or Type 1 Diabetes in Teens. N Engl J Med. 2023;389 (5):474-475. doi: 10.1056/NEJMc2216477. PubMed PMID:37530831 PubMed Central PMC10481371.
  14. Laajala, M, Zwaagstra, M, Martikainen, M, Nekoua, MP, Benkahla, M, Sane, F et al.. Vemurafenib Inhibits Acute and Chronic Enterovirus Infection by Affecting Cellular Kinase Phosphatidylinositol 4-Kinase Type IIIβ. Microbiol Spectr. 2023;11 (4):e0055223. doi: 10.1128/spectrum.00552-23. PubMed PMID:37436162 PubMed Central PMC10433971.
  15. Jouppila, NVV, Lehtonen, J, Seppälä, E, Puustinen, L, Oikarinen, S, Laitinen, OH et al.. Assessment of Enterovirus Antibodies during Early Childhood Using a Multiplex Immunoassay. Microbiol Spectr. 2023;11 (3):e0535222. doi: 10.1128/spectrum.05352-22. PubMed PMID:37227147 PubMed Central PMC10269870.
  16. Liu, X, Johnson, SB, Lynch, KF, Cordan, K, Pate, R, Butterworth, MD et al.. Physical Activity and the Development of Islet Autoimmunity and Type 1 Diabetes in 5- to 15-Year-Old Children Followed in the TEDDY Study. Diabetes Care. 2023;46 (7):1409-1416. doi: 10.2337/dc23-0036. PubMed PMID:37141102 PubMed Central PMC10300517.
  17. Voor, T, Pärtel, M, Peet, A, Saare, L, Hyöty, H, Knip, M et al.. Atopic sensitization in childhood depends on the type of green area around the home in infancy. Clin Exp Allergy. 2023;53 (8):850-853. doi: 10.1111/cea.14317. PubMed PMID:37038920 .
  18. Sioofy-Khojine, AB, Lehtonen, JP, Nurminen, N, Laiho, JE, Toppari, J, Veijola, R et al.. HLA-DQ-conferred risk for type 1 diabetes does not alter neutralizing antibody response to a widely used enterovirus vaccine, the poliovirus vaccine. J Med Virol. 2023;95 (4):e28707. doi: 10.1002/jmv.28707. PubMed PMID:36971180 .
  19. Roslund, MI, Parajuli, A, Hui, N, Puhakka, R, Grönroos, M, Soininen, L et al.. Skin, gut, and sand metagenomic data on placebo-controlled sandbox biodiversity intervention study. Data Brief. 2023;47 :109003. doi: 10.1016/j.dib.2023.109003. PubMed PMID:36915639 PubMed Central PMC10006422.
  20. Thorsen, SU, Liu, X, Kataria, Y, Mandrup-Poulsen, T, Kaur, S, Uusitalo, U et al.. Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study. Diabetes Care. 2023;46 (5):1014-1018. doi: 10.2337/dc22-1359. PubMed PMID:36867433 PubMed Central PMC10154662.
  21. Wu, R, Mumtaz, M, Maxwell, AJ, Isaacs, SR, Laiho, JE, Rawlinson, WD et al.. Respiratory infections and type 1 diabetes: Potential roles in pathogenesis. Rev Med Virol. 2023;33 (2):e2429. doi: 10.1002/rmv.2429. PubMed PMID:36790804 PubMed Central PMC10909571.
  22. Ghalwash, M, Anand, V, Lou, O, Martin, F, Rewers, M, Ziegler, AG et al.. Islet autoantibody screening in at-risk adolescents to predict type 1 diabetes until young adulthood: a prospective cohort study. Lancet Child Adolesc Health. 2023;7 (4):261-268. doi: 10.1016/S2352-4642(22)00350-9. PubMed PMID:36681087 PubMed Central PMC10038928.
  23. Wicaksono, WA, Buko, A, Kusstatscher, P, Cernava, T, Sinkkonen, A, Laitinen, OH et al.. Impact of Cultivation and Origin on the Fruit Microbiome of Apples and Blueberries and Implications for the Exposome. Microb Ecol. 2023;86 (2):973-984. doi: 10.1007/s00248-022-02157-8. PubMed PMID:36542126 PubMed Central PMC10335955.
  24. Luoma, J, Adubra, L, Ashorn, P, Ashorn, U, Bendabenda, J, Dewey, KG et al.. Association between asymptomatic infections and linear growth in 18-24-month-old Malawian children. Matern Child Nutr. 2023;19 (1):e13417. doi: 10.1111/mcn.13417. PubMed PMID:36111423 PubMed Central PMC9749610.

Search PubMed

2022
  1. Vatanen, T, Jabbar, KS, Ruohtula, T, Honkanen, J, Avila-Pacheco, J, Siljander, H et al.. Mobile genetic elements from the maternal microbiome shape infant gut microbial assembly and metabolism. Cell. 2022;185 (26):4921-4936.e15. doi: 10.1016/j.cell.2022.11.023. PubMed PMID:36563663 PubMed Central PMC9869402.
  2. Wicaksono, WA, Buko, A, Kusstatscher, P, Cernava, T, Sinkkonen, A, Laitinen, OH et al.. Impact of Cultivation and Origin on the Fruit Microbiome of Apples and Blueberries and Implications for the Exposome. Microb Ecol. 2023;86 (2):973-984. doi: 10.1007/s00248-022-02157-8. PubMed PMID:36542126 PubMed Central PMC10335955.
  3. Hakola, L, Oikarinen, M, Niinistö, S, Cuthbertson, D, Lehtonen, J, Puustinen, L et al.. Serum 25-hydroxyvitamin D and fatty acids in relation to the risk of microbial infections in children: The TRIGR Divia study. Clin Nutr. 2022;41 (12):2729-2739. doi: 10.1016/j.clnu.2022.10.017. PubMed PMID:36368258 .
  4. Stone, VM, Utorova, R, Butrym, M, Sioofy-Khojine, AB, Hankaniemi, MM, Ringqvist, EE et al.. Coxsackievirus B infections are common in Cystic Fibrosis and experimental evidence supports protection by vaccination. iScience. 2022;25 (10):105070. doi: 10.1016/j.isci.2022.105070. PubMed PMID:36157581 PubMed Central PMC9490033.
  5. Vehik, K, Boulware, D, Killian, M, Rewers, M, McIndoe, R, Toppari, J et al.. Rising Hemoglobin A1c in the Nondiabetic Range Predicts Progression of Type 1 Diabetes As Well As Oral Glucose Tolerance Tests. Diabetes Care. 2022;45 (10):2342-2349. doi: 10.2337/dc22-0828. PubMed PMID:36150054 PubMed Central PMC9587339.
  6. Krischer, JP, Liu, X, Lernmark, Å, Hagopian, WA, Rewers, MJ, She, JX et al.. Predictors of the Initiation of Islet Autoimmunity and Progression to Multiple Autoantibodies and Clinical Diabetes: The TEDDY Study. Diabetes Care. 2022;45 (10):2271-2281. doi: 10.2337/dc21-2612. PubMed PMID:36150053 PubMed Central PMC9643148.
  7. Luoma, J, Adubra, L, Ashorn, P, Ashorn, U, Bendabenda, J, Dewey, KG et al.. Association between asymptomatic infections and linear growth in 18-24-month-old Malawian children. Matern Child Nutr. 2023;19 (1):e13417. doi: 10.1111/mcn.13417. PubMed PMID:36111423 PubMed Central PMC9749610.
  8. Wicaksono, WA, Buko, A, Kusstatscher, P, Sinkkonen, A, Laitinen, OH, Virtanen, SM et al.. Modulation of the food microbiome by apple fruit processing. Food Microbiol. 2022;108 :104103. doi: 10.1016/j.fm.2022.104103. PubMed PMID:36088117 .
  9. Liu, Z, Fan, YM, Ashorn, P, Chingwanda, C, Maleta, K, Hallamaa, L et al.. Lack of Associations between Environmental Exposures and Environmental Enteric Dysfunction among 18-Month-Old Children in Rural Malawi. Int J Environ Res Public Health. 2022;19 (17):. doi: 10.3390/ijerph191710891. PubMed PMID:36078607 PubMed Central PMC9517768.
  10. Roslund, MI, Parajuli, A, Hui, N, Puhakka, R, Grönroos, M, Soininen, L et al.. A Placebo-controlled double-blinded test of the biodiversity hypothesis of immune-mediated diseases: Environmental microbial diversity elicits changes in cytokines and increase in T regulatory cells in young children. Ecotoxicol Environ Saf. 2022;242 :113900. doi: 10.1016/j.ecoenv.2022.113900. PubMed PMID:35930838 .
  11. Sioofy-Khojine, AB, Richardson, SJ, Locke, JM, Oikarinen, S, Nurminen, N, Laine, AP et al.. Detection of enterovirus RNA in peripheral blood mononuclear cells correlates with the presence of the predisposing allele of the type 1 diabetes risk gene IFIH1 and with disease stage. Diabetologia. 2022;65 (10):1701-1709. doi: 10.1007/s00125-022-05753-y. PubMed PMID:35867130 PubMed Central PMC9477938.
  12. Laajala, E, Kalim, UU, Grönroos, T, Rasool, O, Halla-Aho, V, Konki, M et al.. Umbilical cord blood DNA methylation in children who later develop type 1 diabetes. Diabetologia. 2022;65 (9):1534-1540. doi: 10.1007/s00125-022-05726-1. PubMed PMID:35716175 PubMed Central PMC9345803.
  13. Laiho, JE, Laitinen, OH, Malkamäki, J, Puustinen, L, Sinkkonen, A, Pärkkä, J et al.. Exposomic determinants of immune-mediated diseases: Special focus on type 1 diabetes, celiac disease, asthma, and allergies: The HEDIMED project approach. Environ Epidemiol. 2022;6 (3):e212. doi: 10.1097/EE9.0000000000000212. PubMed PMID:35702504 PubMed Central PMC9187189.
  14. Niinistö, S, Miettinen, ME, Cuthbertson, D, Honkanen, J, Hakola, L, Autio, R et al.. Associations Between Serum Fatty Acids and Immunological Markers in Children Developing Islet Autoimmunity-The TRIGR Nested Case-Control Study. Front Immunol. 2022;13 :858875. doi: 10.3389/fimmu.2022.858875. PubMed PMID:35693790 PubMed Central PMC9175567.
  15. Välikangas, T, Lietzén, N, Jaakkola, MK, Krogvold, L, Eike, MC, Kallionpää, H et al.. Pancreas Whole Tissue Transcriptomics Highlights the Role of the Exocrine Pancreas in Patients With Recently Diagnosed Type 1 Diabetes. Front Endocrinol (Lausanne). 2022;13 :861985. doi: 10.3389/fendo.2022.861985. PubMed PMID:35498413 PubMed Central PMC9044038.
  16. Soininen, L, Roslund, MI, Nurminen, N, Puhakka, R, Laitinen, OH, Hyöty, H et al.. Indoor green wall affects health-associated commensal skin microbiota and enhances immune regulation: a randomized trial among urban office workers. Sci Rep. 2022;12 (1):6518. doi: 10.1038/s41598-022-10432-4. PubMed PMID:35444249 PubMed Central PMC9021224.
  17. Hård Af Segerstad, EM, Liu, X, Uusitalo, U, Agardh, D, Andrén Aronsson, C, TEDDY Study Group et al.. Sources of dietary gluten in the first 2 years of life and associations with celiac disease autoimmunity and celiac disease in Swedish genetically predisposed children: The Environmental Determinants of Diabetes in the Young (TEDDY) study. Am J Clin Nutr. 2022;116 (2):394-403. doi: 10.1093/ajcn/nqac086. PubMed PMID:35394004 PubMed Central PMC9348971.
  18. Törn, C, Liu, X, Onengut-Gumuscu, S, Counts, KM, Moreno, JL, Remedios, CL et al.. Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study. Sci Rep. 2022;12 (1):4516. doi: 10.1038/s41598-022-08058-7. PubMed PMID:35296692 PubMed Central PMC8927592.
  19. Li, Z, Veijola, R, Koski, E, Anand, V, Martin, F, Waugh, K et al.. Childhood Height Growth Rate Association With the Risk of Islet Autoimmunity and Development of Type 1 Diabetes. J Clin Endocrinol Metab. 2022;107 (6):1520-1528. doi: 10.1210/clinem/dgac121. PubMed PMID:35244713 PubMed Central PMC9113806.
  20. Ferrat, LA, Vehik, K, Sharp, SA, Lernmark, Å, Rewers, MJ, She, JX et al.. Author Correction: A combined risk score enhances prediction of type 1 diabetes among susceptible children. Nat Med. 2022;28 (3):599. doi: 10.1038/s41591-021-01631-z. PubMed PMID:35165454 .
  21. Suomi, T, Kalim, UU, Rasool, O, Laiho, A, Kallionpää, H, Vähä-Mäkilä, M et al.. Type 1 Diabetes in Children With Genetic Risk May Be Predicted Very Early With a Blood miRNA. Diabetes Care. 2022;45 (4):e77-e79. doi: 10.2337/dc21-2120. PubMed PMID:35134118 PubMed Central PMC9016735.
  22. Jacobsen, LM, Vehik, K, Veijola, R, Warncke, K, Toppari, J, Steck, AK et al.. Heterogeneity of DKA Incidence and Age-Specific Clinical Characteristics in Children Diagnosed With Type 1 Diabetes in the TEDDY Study. Diabetes Care. 2022;45 (3):624-633. doi: 10.2337/dc21-0422. PubMed PMID:35043162 PubMed Central PMC8918232.
  23. Buchacher, T, Honkimaa, A, Välikangas, T, Lietzén, N, Hirvonen, MK, Laiho, JE et al.. Persistent coxsackievirus B1 infection triggers extensive changes in the transcriptome of human pancreatic ductal cells. iScience. 2022;25 (1):103653. doi: 10.1016/j.isci.2021.103653. PubMed PMID:35024587 PubMed Central PMC8728469.
  24. Melin, J, Lynch, KF, Lundgren, M, Aronsson, CA, Larsson, HE, Johnson, SB et al.. Is staff consistency important to parents’ satisfaction in a longitudinal study of children at risk for type 1 diabetes: the TEDDY study. BMC Endocr Disord. 2022;22 (1):19. doi: 10.1186/s12902-021-00929-w. PubMed PMID:35012530 PubMed Central PMC8744326.
  25. González-Rodríguez, MI, Nurminen, N, Kummola, L, Laitinen, OH, Oikarinen, S, Parajuli, A et al.. Effect of inactivated nature-derived microbial composition on mouse immune system. Immun Inflamm Dis. 2022;10 (3):e579. doi: 10.1002/iid3.579. PubMed PMID:34873877 PubMed Central PMC8926502.

Search PubMed

2021
  1. Buchacher, T, Honkimaa, A, Välikangas, T, Lietzén, N, Hirvonen, MK, Laiho, JE et al.. Persistent coxsackievirus B1 infection triggers extensive changes in the transcriptome of human pancreatic ductal cells. iScience. 2022;25 (1):103653. doi: 10.1016/j.isci.2021.103653. PubMed PMID:35024587 PubMed Central PMC8728469.
  2. Bopegamage, S, Berakova, K, Gomocak, P, Baksova, R, Galama, J, Hyoty, H et al.. Primary Site of Coxsackievirus B Replication in the Small Intestines: No Proof of Peyer’s Patches Involvement. Microorganisms. 2021;9 (12):. doi: 10.3390/microorganisms9122600. PubMed PMID:34946201 PubMed Central PMC8709031.
  3. González-Rodríguez, MI, Nurminen, N, Kummola, L, Laitinen, OH, Oikarinen, S, Parajuli, A et al.. Effect of inactivated nature-derived microbial composition on mouse immune system. Immun Inflamm Dis. 2022;10 (3):e579. doi: 10.1002/iid3.579. PubMed PMID:34873877 PubMed Central PMC8926502.
  4. Brænne, I, Onengut-Gumuscu, S, Chen, R, Manichaikul, AW, Rich, SS, Chen, WM et al.. Dynamic changes in immune gene co-expression networks predict development of type 1 diabetes. Sci Rep. 2021;11 (1):22651. doi: 10.1038/s41598-021-01840-z. PubMed PMID:34811390 PubMed Central PMC8609030.
  5. Stone, VM, Butrym, M, Hankaniemi, MM, Sioofy-Khojine, AB, Hytönen, VP, Hyöty, H et al.. Coxsackievirus B Vaccines Prevent Infection-Accelerated Diabetes in NOD Mice and Have No Disease-Inducing Effect. Diabetes. 2021;70 (12):2871-2878. doi: 10.2337/db21-0193. PubMed PMID:34497136 PubMed Central PMC8660981.
  6. Nevalainen, J, Datta, S, Toppari, J, Ilonen, J, Hyöty, H, Veijola, R et al.. Frailty modeling under a selective sampling protocol: an application to type 1 diabetes related autoantibodies. Stat Med. 2021;40 (28):6410-6420. doi: 10.1002/sim.9190. PubMed PMID:34496070 .
  7. Roslund, MI, Puhakka, R, Nurminen, N, Oikarinen, S, Siter, N, Grönroos, M et al.. Long-term biodiversity intervention shapes health-associated commensal microbiota among urban day-care children. Environ Int. 2021;157 :106811. doi: 10.1016/j.envint.2021.106811. PubMed PMID:34403882 .
  8. Oikarinen, S, Krogvold, L, Edwin, B, Buanes, T, Korsgren, O, Laiho, JE et al.. Characterisation of enterovirus RNA detected in the pancreas and other specimens of live patients with newly diagnosed type 1 diabetes in the DiViD study. Diabetologia. 2021;64 (11):2491-2501. doi: 10.1007/s00125-021-05525-0. PubMed PMID:34390364 PubMed Central PMC8494699.
  9. Palmu, T, Lehtonen, J, Korhonen, L, Virtanen, SM, Niemelä, O, Toppari, J et al.. Association of different enteroviruses with atopy and allergic diseases in early childhood. Pediatr Allergy Immunol. 2021;32 (8):1629-1636. doi: 10.1111/pai.13577. PubMed PMID:34219290 .
  10. Haahtela, T, Alenius, H, Lehtimäki, J, Sinkkonen, A, Fyhrquist, N, Hyöty, H et al.. Immunological resilience and biodiversity for prevention of allergic diseases and asthma. Allergy. 2021;76 (12):3613-3626. doi: 10.1111/all.14895. PubMed PMID:33959980 .
  11. Nurminen, N, Cerrone, D, Lehtonen, J, Parajuli, A, Roslund, M, Lönnrot, M et al.. Land Cover of Early-Life Environment Modulates the Risk of Type 1 Diabetes. Diabetes Care. 2021;44 (7):1506-1514. doi: 10.2337/dc20-1719. PubMed PMID:33952607 PubMed Central PMC8323192.
  12. Saarenpää, M, Roslund, MI, Puhakka, R, Grönroos, M, Parajuli, A, Hui, N et al.. Do Rural Second Homes Shape Commensal Microbiota of Urban Dwellers? A Pilot Study among Urban Elderly in Finland. Int J Environ Res Public Health. 2021;18 (7):. doi: 10.3390/ijerph18073742. PubMed PMID:33918486 PubMed Central PMC8038225.
  13. Ruohtula, T, Kondrashova, A, Lehtonen, J, Oikarinen, S, Hämäläinen, AM, Niemelä, O et al.. Immunomodulatory Effects of Rhinovirus and Enterovirus Infections During the First Year of Life. Front Immunol. 2020;11 :567046. doi: 10.3389/fimmu.2020.567046. PubMed PMID:33643278 PubMed Central PMC7905218.
  14. Bonifacio, E, Weiß, A, Winkler, C, Hippich, M, Rewers, MJ, Toppari, J et al.. An Age-Related Exponential Decline in the Risk of Multiple Islet Autoantibody Seroconversion During Childhood. Diabetes Care. 2021;44 (10):2260-8. doi: 10.2337/dc20-2122. PubMed PMID:33627366 PubMed Central PMC8929192.
  15. Oikarinen, M, Puustinen, L, Lehtonen, J, Hakola, L, Simell, S, Toppari, J et al.. Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study. Front Immunol. 2020;11 :604529. doi: 10.3389/fimmu.2020.604529. PubMed PMID:33603739 PubMed Central PMC7884453.
  16. Hakola, L, Erlund, I, Cuthbertson, D, Miettinen, ME, Autio, R, Nucci, AM et al.. Serum fatty acids and risk of developing islet autoimmunity: A nested case-control study within the TRIGR birth cohort. Pediatr Diabetes. 2021;22 (4):577-585. doi: 10.1111/pedi.13189. PubMed PMID:33543815 .
  17. Maleta, K, Fan, YM, Luoma, J, Ashorn, U, Bendabenda, J, Dewey, KG et al.. Infections and systemic inflammation are associated with lower plasma concentration of insulin-like growth factor I among Malawian children. Am J Clin Nutr. 2021;113 (2):380-390. doi: 10.1093/ajcn/nqaa327. PubMed PMID:33381802 PubMed Central PMC7851819.
  18. Vari, HK, Roslund, MI, Oikarinen, S, Nurminen, N, Puhakka, R, Parajuli, A et al.. Associations between land cover categories, gaseous PAH levels in ambient air and endocrine signaling predicted from gut bacterial metagenome of the elderly. Chemosphere. 2021;265 :128965. doi: 10.1016/j.chemosphere.2020.128965. PubMed PMID:33248729 .
  19. Liu, Z, Fan, YM, Ashorn, P, Cheung, YB, Hallamaa, L, Hyöty, H et al.. Faecal regenerating 1B protein concentration is not associated with child growth in rural Malawi. J Paediatr Child Health. 2021;57 (3):388-394. doi: 10.1111/jpc.15231. PubMed PMID:33112481 PubMed Central PMC8048694.

Search PubMed

2020
  1. Ruohtula, T, Kondrashova, A, Lehtonen, J, Oikarinen, S, Hämäläinen, AM, Niemelä, O et al.. Immunomodulatory Effects of Rhinovirus and Enterovirus Infections During the First Year of Life. Front Immunol. 2020;11 :567046. doi: 10.3389/fimmu.2020.567046. PubMed PMID:33643278 PubMed Central PMC7905218.
  2. Oikarinen, M, Puustinen, L, Lehtonen, J, Hakola, L, Simell, S, Toppari, J et al.. Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study. Front Immunol. 2020;11 :604529. doi: 10.3389/fimmu.2020.604529. PubMed PMID:33603739 PubMed Central PMC7884453.
  3. Salmikangas, S, Laiho, JE, Kalander, K, Laajala, M, Honkimaa, A, Shanina, I et al.. Detection of Viral -RNA and +RNA Strands in Enterovirus-Infected Cells and Tissues. Microorganisms. 2020;8 (12):. doi: 10.3390/microorganisms8121928. PubMed PMID:33291747 PubMed Central PMC7761939.
  4. Vari, HK, Roslund, MI, Oikarinen, S, Nurminen, N, Puhakka, R, Parajuli, A et al.. Associations between land cover categories, gaseous PAH levels in ambient air and endocrine signaling predicted from gut bacterial metagenome of the elderly. Chemosphere. 2021;265 :128965. doi: 10.1016/j.chemosphere.2020.128965. PubMed PMID:33248729 .
  5. Honkimaa, A, Kimura, B, Sioofy-Khojine, AB, Lin, J, Laiho, J, Oikarinen, S et al.. Genetic Adaptation of Coxsackievirus B1 during Persistent Infection in Pancreatic Cells. Microorganisms. 2020;8 (11):. doi: 10.3390/microorganisms8111790. PubMed PMID:33203081 PubMed Central PMC7697981.
  6. Liu, Z, Fan, YM, Ashorn, P, Cheung, YB, Hallamaa, L, Hyöty, H et al.. Faecal regenerating 1B protein concentration is not associated with child growth in rural Malawi. J Paediatr Child Health. 2021;57 (3):388-394. doi: 10.1111/jpc.15231. PubMed PMID:33112481 PubMed Central PMC8048694.
  7. Roslund, MI, Puhakka, R, Grönroos, M, Nurminen, N, Oikarinen, S, Gazali, AM et al.. Biodiversity intervention enhances immune regulation and health-associated commensal microbiota among daycare children. Sci Adv. 2020;6 (42):. doi: 10.1126/sciadv.aba2578. PubMed PMID:33055153 PubMed Central PMC7556828.
  8. Saarinen, NVV, Lehtonen, J, Veijola, R, Lempainen, J, Knip, M, Hyöty, H et al.. Correction: Saarinen, N.V.V., et al. Multiplexed High-Throughput Serological Assay for Human Enteroviruses. 2020, , 963. Microorganisms. 2020;8 (9):. doi: 10.3390/microorganisms8091426. PubMed PMID:32957450 PubMed Central PMC7563745.
  9. Hankaniemi, MM, Baikoghli, MA, Stone, VM, Xing, L, Väätäinen, O, Soppela, S et al.. Structural Insight into CVB3-VLP Non-Adjuvanted Vaccine. Microorganisms. 2020;8 (9):. doi: 10.3390/microorganisms8091287. PubMed PMID:32846899 PubMed Central PMC7565060.
  10. Sinisalu, L, Sen, P, Salihović, S, Virtanen, SM, Hyöty, H, Ilonen, J et al.. Early-life exposure to perfluorinated alkyl substances modulates lipid metabolism in progression to celiac disease. Environ Res. 2020;188 :109864. doi: 10.1016/j.envres.2020.109864. PubMed PMID:32846648 .
  11. Ferrat, LA, Vehik, K, Sharp, SA, Lernmark, Å, Rewers, MJ, She, JX et al.. A combined risk score enhances prediction of type 1 diabetes among susceptible children. Nat Med. 2020;26 (8):1247-1255. doi: 10.1038/s41591-020-0930-4. PubMed PMID:32770166 PubMed Central PMC7556983.
  12. Oikarinen, M, Bertolet, L, Toniolo, A, Oikarinen, S, Laiho, JE, Pugliese, A et al.. Differential Detection of Encapsidated versus Unencapsidated Enterovirus RNA in Samples Containing Pancreatic Enzymes-Relevance for Diabetes Studies. Viruses. 2020;12 (7):. doi: 10.3390/v12070747. PubMed PMID:32664501 PubMed Central PMC7411921.
  13. Vehik, K, Bonifacio, E, Lernmark, Å, Yu, L, Williams, A, Schatz, D et al.. Hierarchical Order of Distinct Autoantibody Spreading and Progression to Type 1 Diabetes in the TEDDY Study. Diabetes Care. 2020;43 (9):2066-2073. doi: 10.2337/dc19-2547. PubMed PMID:32641373 PubMed Central PMC7440899.
  14. Saarinen, NVV, Lehtonen, J, Veijola, R, Lempainen, J, Knip, M, Hyöty, H et al.. Multiplexed High-Throughput Serological Assay for Human Enteroviruses. Microorganisms. 2020;8 (6):. doi: 10.3390/microorganisms8060963. PubMed PMID:32604930 PubMed Central PMC7355947.
  15. Stone, VM, Hankaniemi, MM, Laitinen, OH, Sioofy-Khojine, AB, Lin, A, Diaz Lozano, IM et al.. A hexavalent Coxsackievirus B vaccine is highly immunogenic and has a strong protective capacity in mice and nonhuman primates. Sci Adv. 2020;6 (19):eaaz2433. doi: 10.1126/sciadv.aaz2433. PubMed PMID:32494709 PubMed Central PMC7202868.
  16. Honkimaa, A, Sioofy-Khojine, AB, Oikarinen, S, Bertin, A, Hober, D, Hyöty, H et al.. Eradication of persistent coxsackievirus B infection from a pancreatic cell line with clinically used antiviral drugs. J Clin Virol. 2020;128 :104334. doi: 10.1016/j.jcv.2020.104334. PubMed PMID:32450550 .
  17. Sane, F, Bertin, A, Sioofy-Khojine, AB, Oikarinen, S, Alidjinou, EK, Veijola, R et al.. Enhancing and neutralizing anti-coxsackievirus activities in serum samples from patients prior to development of type 1 diabetes. Diabetes Metab Res Rev. 2020;36 (6):e3305. doi: 10.1002/dmrr.3305. PubMed PMID:32118346 .
  18. Seppälä, EM, Oikarinen, S, Lehtonen, JP, Neupane, S, Honkanen, H, Tyni, I et al.. Association of Picornavirus Infections With Acute Otitis Media in a Prospective Birth Cohort Study. J Infect Dis. 2020;222 (2):324-332. doi: 10.1093/infdis/jiaa087. PubMed PMID:32108877 .
  19. Sen, P, Dickens, AM, López-Bascón, MA, Lindeman, T, Kemppainen, E, Lamichhane, S et al.. Metabolic alterations in immune cells associate with progression to type 1 diabetes. Diabetologia. 2020;63 (5):1017-1031. doi: 10.1007/s00125-020-05107-6. PubMed PMID:32043185 PubMed Central PMC7145788.
  20. Li, Q, Parikh, H, Butterworth, MD, Lernmark, Å, Hagopian, W, Rewers, M et al.. Longitudinal Metabolome-Wide Signals Prior to the Appearance of a First Islet Autoantibody in Children Participating in the TEDDY Study. Diabetes. 2020;69 (3):465-476. doi: 10.2337/db19-0756. PubMed PMID:32029481 PubMed Central PMC7034190.
  21. Parajuli, A, Hui, N, Puhakka, R, Oikarinen, S, Grönroos, M, Selonen, VAO et al.. Yard vegetation is associated with gut microbiota composition. Sci Total Environ. 2020;713 :136707. doi: 10.1016/j.scitotenv.2020.136707. PubMed PMID:32019041 .
  22. Saarinen, NVV, Stone, VM, Hankaniemi, MM, Mazur, MA, Vuorinen, T, Flodström-Tullberg, M et al.. Antibody Responses against Enterovirus Proteases are Potential Markers for an Acute Infection. Viruses. 2020;12 (1):. doi: 10.3390/v12010078. PubMed PMID:31936473 PubMed Central PMC7020046.
  23. Miettinen, ME, Niinistö, S, Erlund, I, Cuthbertson, D, Nucci, AM, Honkanen, J et al.. Serum 25-hydroxyvitamin D concentration in childhood and risk of islet autoimmunity and type 1 diabetes: the TRIGR nested case-control ancillary study. Diabetologia. 2020;63 (4):780-787. doi: 10.1007/s00125-019-05077-4. PubMed PMID:31912198 PubMed Central PMC7054378.
  24. Liu, X, Vehik, K, Huang, Y, Elding Larsson, H, Toppari, J, Ziegler, AG et al.. Distinct Growth Phases in Early Life Associated With the Risk of Type 1 Diabetes: The TEDDY Study. Diabetes Care. 2020;43 (3):556-562. doi: 10.2337/dc19-1670. PubMed PMID:31896601 PubMed Central PMC7035588.
  25. Ojwang, V, Nwaru, BI, Takkinen, HM, Kaila, M, Niemelä, O, Haapala, AM et al.. Early exposure to cats, dogs and farm animals and the risk of childhood asthma and allergy. Pediatr Allergy Immunol. 2020;31 (3):265-272. doi: 10.1111/pai.13186. PubMed PMID:31829464 .
  26. Lindfors, K, Lin, J, Lee, HS, Hyöty, H, Nykter, M, Kurppa, K et al.. Metagenomics of the faecal virome indicate a cumulative effect of enterovirus and gluten amount on the risk of coeliac disease autoimmunity in genetically at risk children: the TEDDY study. Gut. 2020;69 (8):1416-1422. doi: 10.1136/gutjnl-2019-319809. PubMed PMID:31744911 PubMed Central PMC7234892.
  27. Sioofy-Khojine, AB, Honkimaa, A, Hyöty, H. A preclinical assessment to repurpose drugs to target type 1 diabetes-associated type B coxsackieviruses. Diabet Med. 2020;37 (11):1849-1853. doi: 10.1111/dme.14175. PubMed PMID:31705692 .

Search PubMed

2019
  1. Vehik, K, Lynch, KF, Wong, MC, Tian, X, Ross, MC, Gibbs, RA et al.. Prospective virome analyses in young children at increased genetic risk for type 1 diabetes. Nat Med. 2019;25 (12):1865-1872. doi: 10.1038/s41591-019-0667-0. PubMed PMID:31792456 PubMed Central PMC6898786.
  2. Lindfors, K, Lin, J, Lee, HS, Hyöty, H, Nykter, M, Kurppa, K et al.. Metagenomics of the faecal virome indicate a cumulative effect of enterovirus and gluten amount on the risk of coeliac disease autoimmunity in genetically at risk children: the TEDDY study. Gut. 2020;69 (8):1416-1422. doi: 10.1136/gutjnl-2019-319809. PubMed PMID:31744911 PubMed Central PMC7234892.
  3. Sioofy-Khojine, AB, Honkimaa, A, Hyöty, H. A preclinical assessment to repurpose drugs to target type 1 diabetes-associated type B coxsackieviruses. Diabet Med. 2020;37 (11):1849-1853. doi: 10.1111/dme.14175. PubMed PMID:31705692 .
  4. Johnson, RK, Vanderlinden, L, DeFelice, BC, Kechris, K, Uusitalo, U, Fiehn, O et al.. Metabolite-related dietary patterns and the development of islet autoimmunity. Sci Rep. 2019;9 (1):14819. doi: 10.1038/s41598-019-51251-4. PubMed PMID:31616039 PubMed Central PMC6794249.
  5. Heinimäki, S, Hankaniemi, MM, Sioofy-Khojine, AB, Laitinen, OH, Hyöty, H, Hytönen, VP et al.. Combination of three virus-derived nanoparticles as a vaccine against enteric pathogens; enterovirus, norovirus and rotavirus. Vaccine. 2019;37 (51):7509-7518. doi: 10.1016/j.vaccine.2019.09.072. PubMed PMID:31585726 .
  6. Frank, NM, Lynch, KF, Uusitalo, U, Yang, J, Lönnrot, M, Virtanen, SM et al.. The relationship between breastfeeding and reported respiratory and gastrointestinal infection rates in young children. BMC Pediatr. 2019;19 (1):339. doi: 10.1186/s12887-019-1693-2. PubMed PMID:31533753 PubMed Central PMC6749679.
  7. Hankaniemi, MM, Stone, VM, Andrejeff, T, Heinimäki, S, Sioofy-Khojine, AB, Marjomäki, V et al.. Formalin treatment increases the stability and immunogenicity of coxsackievirus B1 VLP vaccine. Antiviral Res. 2019;171 :104595. doi: 10.1016/j.antiviral.2019.104595. PubMed PMID:31491431 .
  8. Hankaniemi, MM, Stone, VM, Sioofy-Khojine, AB, Heinimäki, S, Marjomäki, V, Hyöty, H et al.. A comparative study of the effect of UV and formalin inactivation on the stability and immunogenicity of a Coxsackievirus B1 vaccine. Vaccine. 2019;37 (40):5962-5971. doi: 10.1016/j.vaccine.2019.08.037. PubMed PMID:31471148 .
  9. Lamichhane, S, Kemppainen, E, Trošt, K, Siljander, H, Hyöty, H, Ilonen, J et al.. Circulating metabolites in progression to islet autoimmunity and type 1 diabetes. Diabetologia. 2019;62 (12):2287-2297. doi: 10.1007/s00125-019-04980-0. PubMed PMID:31444528 PubMed Central PMC6861356.
  10. Lietzén, N, Hirvonen, K, Honkimaa, A, Buchacher, T, Laiho, JE, Oikarinen, S et al.. Coxsackievirus B Persistence Modifies the Proteome and the Secretome of Pancreatic Ductal Cells. iScience. 2019;19 :340-357. doi: 10.1016/j.isci.2019.07.040. PubMed PMID:31404834 PubMed Central PMC6699423.
  11. Hui, N, Parajuli, A, Puhakka, R, Grönroos, M, Roslund, MI, Vari, HK et al.. Temporal variation in indoor transfer of dirt-associated environmental bacteria in agricultural and urban areas. Environ Int. 2019;132 :105069. doi: 10.1016/j.envint.2019.105069. PubMed PMID:31400602 .
  12. Edwards, RA, Vega, AA, Norman, HM, Ohaeri, M, Levi, K, Dinsdale, EA et al.. Global phylogeography and ancient evolution of the widespread human gut virus crAssphage. Nat Microbiol. 2019;4 (10):1727-1736. doi: 10.1038/s41564-019-0494-6. PubMed PMID:31285584 PubMed Central PMC7440971.
  13. Roslund, MI, Rantala, S, Oikarinen, S, Puhakka, R, Hui, N, Parajuli, A et al.. Endocrine disruption and commensal bacteria alteration associated with gaseous and soil PAH contamination among daycare children. Environ Int. 2019;130 :104894. doi: 10.1016/j.envint.2019.06.004. PubMed PMID:31220749 .
  14. Mustonen, N, Siljander, H, Peet, A, Tillmann, V, Härkönen, T, Ilonen, J et al.. Early childhood infections and the use of antibiotics and antipyretic-analgesics in Finland, Estonia and Russian Karelia. Acta Paediatr. 2019;108 (11):2075-2082. doi: 10.1111/apa.14874. PubMed PMID:31132164 .
  15. Sen, P, Carlsson, C, Virtanen, SM, Simell, S, Hyöty, H, Ilonen, J et al.. Persistent Alterations in Plasma Lipid Profiles Before Introduction of Gluten in the Diet Associated With Progression to Celiac Disease. Clin Transl Gastroenterol. 2019;10 (5):1-10. doi: 10.14309/ctg.0000000000000044. PubMed PMID:31082858 PubMed Central PMC6602763.
  16. Lehto, KM, Fan, YM, Oikarinen, S, Nurminen, N, Hallamaa, L, Juuti, R et al.. Presence of Giardia lamblia in stools of six- to 18-month old asymptomatic Malawians is associated with children’s growth failure. Acta Paediatr. 2019;108 (10):1833-1840. doi: 10.1111/apa.14832. PubMed PMID:31038225 PubMed Central PMC6790611.
  17. Dunne, JL, Richardson, SJ, Atkinson, MA, Craig, ME, Dahl-Jørgensen, K, Flodström-Tullberg, M et al.. Large enteroviral vaccination studies to prevent type 1 diabetes should be well founded and rely on scientific evidence. Reply to Skog O, Klingel K, Roivainen M et al [letter]. Diabetologia. 2019;62 (6):1100-1103. doi: 10.1007/s00125-019-4873-6. PubMed PMID:31016358 .
  18. Krischer, JP, Liu, X, Vehik, K, Akolkar, B, Hagopian, WA, Rewers, MJ et al.. Predicting Islet Cell Autoimmunity and Type 1 Diabetes: An 8-Year TEDDY Study Progress Report. Diabetes Care. 2019;42 (6):1051-1060. doi: 10.2337/dc18-2282. PubMed PMID:30967432 PubMed Central PMC6609953.
  19. Simre, K, Uibo, O, Peet, A, Puustinen, L, Oikarainen, S, Tamminen, K et al.. Early-life exposure to common virus infections did not differ between coeliac disease patients and controls. Acta Paediatr. 2019;108 (9):1709-1716. doi: 10.1111/apa.14791. PubMed PMID:30896051 .
  20. Fan, YM, Oikarinen, S, Lehto, KM, Nurminen, N, Juuti, R, Mangani, C et al.. High prevalence of selected viruses and parasites and their predictors in Malawian children. Epidemiol Infect. 2019;147 :e90. doi: 10.1017/S0950268819000025. PubMed PMID:30869004 PubMed Central PMC6521582.
  21. Korhonen, L, Oikarinen, S, Lehtonen, J, Mustonen, N, Tyni, I, Niemelä, O et al.. Rhinoviruses in infancy and risk of immunoglobulin E sensitization. J Med Virol. 2019;91 (8):1470-1478. doi: 10.1002/jmv.25455. PubMed PMID:30866076 .
  22. Malm, M, Hyöty, H, Knip, M, Vesikari, T, Blazevic, V. Development of T cell immunity to norovirus and rotavirus in children under five years of age. Sci Rep. 2019;9 (1):3199. doi: 10.1038/s41598-019-39840-9. PubMed PMID:30824789 PubMed Central PMC6397277.
  23. Roth, R, Lynch, K, Hyöty, H, Lönnrot, M, Driscoll, KA, Bennett Johnson, S et al.. The association between stressful life events and respiratory infections during the first 4 years of life: The Environmental Determinants of Diabetes in the Young study. Stress Health. 2019;35 (3):289-303. doi: 10.1002/smi.2861. PubMed PMID:30768831 PubMed Central PMC6697245.
  24. Dunne, JL, Richardson, SJ, Atkinson, MA, Craig, ME, Dahl-Jørgensen, K, Flodström-Tullberg, M et al.. Rationale for enteroviral vaccination and antiviral therapies in human type 1 diabetes. Diabetologia. 2019;62 (5):744-753. doi: 10.1007/s00125-019-4811-7. PubMed PMID:30675626 PubMed Central PMC6450860.
  25. Lamichhane, S, Ahonen, L, Dyrlund, TS, Dickens, AM, Siljander, H, Hyöty, H et al.. Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes. Biomolecules. 2019;9 (1):. doi: 10.3390/biom9010033. PubMed PMID:30669674 PubMed Central PMC6359525.
  26. Mäkinen, M, Löyttyniemi, E, Koskinen, M, Vähä-Mäkilä, M, Siljander, H, Nurmio, M et al.. Serum 25-Hydroxyvitamin D Concentrations at Birth in Children Screened for HLA-DQB1 Conferred Risk for Type 1 Diabetes. J Clin Endocrinol Metab. 2019;104 (6):2277-2285. doi: 10.1210/jc.2018-02094. PubMed PMID:30657906 PubMed Central PMC6489691.
  27. Hippich, M, Beyerlein, A, Hagopian, WA, Krischer, JP, Vehik, K, Knoop, J et al.. Genetic Contribution to the Divergence in Type 1 Diabetes Risk Between Children From the General Population and Children From Affected Families. Diabetes. 2019;68 (4):847-857. doi: 10.2337/db18-0882. PubMed PMID:30655385 PubMed Central PMC6425872.
  28. Jääskeläinen, AJ, Nurminen, N, Kolehmainen, P, Smura, T, Tauriainen, S, Toppari, J et al.. No Association Between Ljungan Virus Seropositivity and the Beta-cell Damaging Process in the Finnish Type 1 Diabetes Prediction and Prevention Study Cohort. Pediatr Infect Dis J. 2019;38 (3):314-316. doi: 10.1097/INF.0000000000002201. PubMed PMID:30346370 .
  29. Ekman, I, Vuorinen, T, Knip, M, Veijola, R, Toppari, J, Hyöty, H et al.. Early childhood CMV infection may decelerate the progression to clinical type 1 diabetes. Pediatr Diabetes. 2019;20 (1):73-77. doi: 10.1111/pedi.12788. PubMed PMID:30338642 .
  30. Endesfelder, D, Zu Castell, W, Bonifacio, E, Rewers, M, Hagopian, WA, She, JX et al.. Time-Resolved Autoantibody Profiling Facilitates Stratification of Preclinical Type 1 Diabetes in Children. Diabetes. 2019;68 (1):119-130. doi: 10.2337/db18-0594. PubMed PMID:30305370 PubMed Central PMC6302536.
  31. Grönroos, M, Parajuli, A, Laitinen, OH, Roslund, MI, Vari, HK, Hyöty, H et al.. Short-term direct contact with soil and plant materials leads to an immediate increase in diversity of skin microbiota. Microbiologyopen. 2019;8 (3):e00645. doi: 10.1002/mbo3.645. PubMed PMID:29808965 PubMed Central PMC6436432.

Search PubMed

2018
  1. Hyöty, H, Leon, F, Knip, M. Developing a vaccine for type 1 diabetes by targeting coxsackievirus B. Expert Rev Vaccines. 2018;17 (12):1071-1083. doi: 10.1080/14760584.2018.1548281. PubMed PMID:30449209 .
  2. Lamichhane, S, Ahonen, L, Dyrlund, TS, Siljander, H, Hyöty, H, Ilonen, J et al.. A longitudinal plasma lipidomics dataset from children who developed islet autoimmunity and type 1 diabetes. Sci Data. 2018;5 :180250. doi: 10.1038/sdata.2018.250. PubMed PMID:30422126 PubMed Central PMC6233478.
  3. Stewart, CJ, Ajami, NJ, O’Brien, JL, Hutchinson, DS, Smith, DP, Wong, MC et al.. Temporal development of the gut microbiome in early childhood from the TEDDY study. Nature. 2018;562 (7728):583-588. doi: 10.1038/s41586-018-0617-x. PubMed PMID:30356187 PubMed Central PMC6415775.
  4. Rewers, M, Hyöty, H, Lernmark, Å, Hagopian, W, She, JX, Schatz, D et al.. The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update. Curr Diab Rep. 2018;18 (12):136. doi: 10.1007/s11892-018-1113-2. PubMed PMID:30353256 PubMed Central PMC6415767.
  5. Ekman, I, Vuorinen, T, Knip, M, Veijola, R, Toppari, J, Hyöty, H et al.. Early childhood CMV infection may decelerate the progression to clinical type 1 diabetes. Pediatr Diabetes. 2019;20 (1):73-77. doi: 10.1111/pedi.12788. PubMed PMID:30338642 .
  6. Endesfelder, D, Zu Castell, W, Bonifacio, E, Rewers, M, Hagopian, WA, She, JX et al.. Time-Resolved Autoantibody Profiling Facilitates Stratification of Preclinical Type 1 Diabetes in Children. Diabetes. 2019;68 (1):119-130. doi: 10.2337/db18-0594. PubMed PMID:30305370 PubMed Central PMC6302536.
  7. Korhonen, L, Seiskari, T, Lehtonen, J, Puustinen, L, Surcel, HM, Haapala, AM et al.. Enterovirus infection during pregnancy is inversely associated with atopic disease in the offspring. Clin Exp Allergy. 2018;48 (12):1698-1704. doi: 10.1111/cea.13280. PubMed PMID:30230072 .
  8. Sioofy-Khojine, AB, Oikarinen, S, Honkanen, H, Huhtala, H, Lehtonen, JP, Briese, T et al.. Molecular epidemiology of enteroviruses in young children at increased risk of type 1 diabetes. PLoS One. 2018;13 (9):e0201959. doi: 10.1371/journal.pone.0201959. PubMed PMID:30192755 PubMed Central PMC6128458.
  9. Salami, F, Lee, HS, Freyhult, E, Elding Larsson, H, Lernmark, Å, Törn, C et al.. Reduction in White Blood Cell, Neutrophil, and Red Blood Cell Counts Related to Sex, HLA, and Islet Autoantibodies in Swedish TEDDY Children at Increased Risk for Type 1 Diabetes. Diabetes. 2018;67 (11):2329-2336. doi: 10.2337/db18-0355. PubMed PMID:30104249 PubMed Central PMC6198343.
  10. Lamichhane, S, Ahonen, L, Dyrlund, TS, Kemppainen, E, Siljander, H, Hyöty, H et al.. Dynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes – Type 1 Diabetes Prediction and Prevention Study (DIPP). Sci Rep. 2018;8 (1):10635. doi: 10.1038/s41598-018-28907-8. PubMed PMID:30006587 PubMed Central PMC6045612.
  11. Yassour, M, Jason, E, Hogstrom, LJ, Arthur, TD, Tripathi, S, Siljander, H et al.. Strain-Level Analysis of Mother-to-Child Bacterial Transmission during the First Few Months of Life. Cell Host Microbe. 2018;24 (1):146-154.e4. doi: 10.1016/j.chom.2018.06.007. PubMed PMID:30001517 PubMed Central PMC6091882.
  12. Grönroos, M, Parajuli, A, Laitinen, OH, Roslund, MI, Vari, HK, Hyöty, H et al.. Short-term direct contact with soil and plant materials leads to an immediate increase in diversity of skin microbiota. Microbiologyopen. 2019;8 (3):e00645. doi: 10.1002/mbo3.645. PubMed PMID:29808965 PubMed Central PMC6436432.
  13. Nurminen, N, Lin, J, Grönroos, M, Puhakka, R, Kramna, L, Vari, HK et al.. Nature-derived microbiota exposure as a novel immunomodulatory approach. Future Microbiol. 2018;13 :737-744. doi: 10.2217/fmb-2017-0286. PubMed PMID:29771153 .
  14. Stanfill, BA, Nakayasu, ES, Bramer, LM, Thompson, AM, Ansong, CK, Clauss, TR et al.. Quality Control Analysis in Real-time (QC-ART): A Tool for Real-time Quality Control Assessment of Mass Spectrometry-based Proteomics Data. Mol Cell Proteomics. 2018;17 (9):1824-1836. doi: 10.1074/mcp.RA118.000648. PubMed PMID:29666158 PubMed Central PMC6126382.
  15. Ponsonby, AL, Pezic, A, Cameron, FJ, Rodda, C, Kemp, AS, Carlin, JB et al.. Higher parental occupational social contact is associated with a reduced risk of incident pediatric type 1 diabetes: Mediation through molecular enteroviral indices. PLoS One. 2018;13 (4):e0193992. doi: 10.1371/journal.pone.0193992. PubMed PMID:29664909 PubMed Central PMC5903611.
  16. Roslund, MI, Grönroos, M, Rantalainen, AL, Jumpponen, A, Romantschuk, M, Parajuli, A et al.. Half-lives of PAHs and temporal microbiota changes in commonly used urban landscaping materials. PeerJ. 2018;6 :e4508. doi: 10.7717/peerj.4508. PubMed PMID:29576975 PubMed Central PMC5863720.
  17. Lind, A, Lynch, KF, Lundgren, M, Lernmark, Å, Almgren, P, Ramelius, A et al.. First trimester enterovirus IgM and beta cell autoantibodies in mothers to children affected by type 1 diabetes autoimmunity before 7 years of age. J Reprod Immunol. 2018;127 :1-6. doi: 10.1016/j.jri.2018.02.004. PubMed PMID:29550618 .
  18. Parajuli, A, Grönroos, M, Siter, N, Puhakka, R, Vari, HK, Roslund, MI et al.. Urbanization Reduces Transfer of Diverse Environmental Microbiota Indoors. Front Microbiol. 2018;9 :84. doi: 10.3389/fmicb.2018.00084. PubMed PMID:29467728 PubMed Central PMC5808279.
  19. Laitinen, OH, Svedin, E, Kapell, S, Hankaniemi, MM, Larsson, PG, Domsgen, E et al.. New Coxsackievirus 2Apro and 3Cpro protease antibodies for virus detection and discovery of pathogenic mechanisms. J Virol Methods. 2018;255 :29-37. doi: 10.1016/j.jviromet.2018.02.001. PubMed PMID:29425680 .
  20. Sioofy-Khojine, AB, Lehtonen, J, Nurminen, N, Laitinen, OH, Oikarinen, S, Huhtala, H et al.. Coxsackievirus B1 infections are associated with the initiation of insulin-driven autoimmunity that progresses to type 1 diabetes. Diabetologia. 2018;61 (5):1193-1202. doi: 10.1007/s00125-018-4561-y. PubMed PMID:29404673 .
  21. Uusitalo, U, Lee, HS, Andrén Aronsson, C, Vehik, K, Yang, J, Hummel, S et al.. Early Infant Diet and Islet Autoimmunity in the TEDDY Study. Diabetes Care. 2018;41 (3):522-530. doi: 10.2337/dc17-1983. PubMed PMID:29343517 PubMed Central PMC5829968.
  22. Saarinen, NVV, Laiho, JE, Richardson, SJ, Zeissler, M, Stone, VM, Marjomäki, V et al.. A novel rat CVB1-VP1 monoclonal antibody 3A6 detects a broad range of enteroviruses. Sci Rep. 2018;8 (1):33. doi: 10.1038/s41598-017-18495-4. PubMed PMID:29311608 PubMed Central PMC5758616.
  23. Cinek, O, Mazankova, K, Kramna, L, Odeh, R, Alassaf, A, Ibekwe, MU et al.. Quantitative CrAssphage real-time PCR assay derived from data of multiple geographically distant populations. J Med Virol. 2018;90 (4):767-771. doi: 10.1002/jmv.25012. PubMed PMID:29297933 .
  24. Stone, VM, Hankaniemi, MM, Svedin, E, Sioofy-Khojine, A, Oikarinen, S, Hyöty, H et al.. A Coxsackievirus B vaccine protects against virus-induced diabetes in an experimental mouse model of type 1 diabetes. Diabetologia. 2018;61 (2):476-481. doi: 10.1007/s00125-017-4492-z. PubMed PMID:29151123 PubMed Central PMC6448957.
  25. Lietzen, N, An, LTT, Jaakkola, MK, Kallionpää, H, Oikarinen, S, Mykkänen, J et al.. Enterovirus-associated changes in blood transcriptomic profiles of children with genetic susceptibility to type 1 diabetes. Diabetologia. 2018;61 (2):381-388. doi: 10.1007/s00125-017-4460-7. PubMed PMID:29119244 PubMed Central PMC6448961.
  26. Lönnrot, M, Lynch, KF, Elding Larsson, H, Lernmark, Å, Rewers, MJ, Törn, C et al.. Correction to: Respiratory infections are temporally associated with initiation of type 1 diabetes autoimmunity: the TEDDY study. Diabetologia. 2018;61 (1):254. doi: 10.1007/s00125-017-4487-9. PubMed PMID:29080005 .
  27. Norris, JM, Lee, HS, Frederiksen, B, Erlund, I, Uusitalo, U, Yang, J et al.. Plasma 25-Hydroxyvitamin D Concentration and Risk of Islet Autoimmunity. Diabetes. 2018;67 (1):146-154. doi: 10.2337/db17-0802. PubMed PMID:29061729 PubMed Central PMC5741144.
  28. Kondrashova, A, Nurminen, N, Lehtonen, J, Hyöty, M, Toppari, J, Ilonen, J et al.. Exocrine pancreas function decreases during the progression of the beta-cell damaging process in young prediabetic children. Pediatr Diabetes. 2018;19 (3):398-402. doi: 10.1111/pedi.12592. PubMed PMID:29044779 .
  29. Elding Larsson, H, Lynch, KF, Lönnrot, M, Haller, MJ, Lernmark, Å, Hagopian, WA et al.. Pandemrix® vaccination is not associated with increased risk of islet autoimmunity or type 1 diabetes in the TEDDY study children. Diabetologia. 2018;61 (1):193-202. doi: 10.1007/s00125-017-4448-3. PubMed PMID:28990147 PubMed Central PMC5774660.
  30. Lynch, KF, Lee, HS, Törn, C, Vehik, K, Krischer, JP, Larsson, HE et al.. Gestational respiratory infections interacting with offspring HLA and CTLA-4 modifies incident β-cell autoantibodies. J Autoimmun. 2018;86 :93-103. doi: 10.1016/j.jaut.2017.09.005. PubMed PMID:28941965 PubMed Central PMC5747989.
  31. Viskari, H, Oikarinen, S, Hoppu, S, Vuorinen, T, Huhtala, H, Toppari, J et al.. Live attenuated enterovirus vaccine (OPV) is not associated with islet autoimmunity in children with genetic susceptibility to type 1 diabetes: prospective cohort study. Diabetologia. 2018;61 (1):203-209. doi: 10.1007/s00125-017-4410-4. PubMed PMID:28866779 .
  32. Mustonen, N, Siljander, H, Peet, A, Tillmann, V, Härkönen, T, Ilonen, J et al.. Early childhood infections precede development of beta-cell autoimmunity and type 1 diabetes in children with HLA-conferred disease risk. Pediatr Diabetes. 2018;19 (2):293-299. doi: 10.1111/pedi.12547. PubMed PMID:28597957 .

Search PubMed

2017
  1. Stone, VM, Hankaniemi, MM, Svedin, E, Sioofy-Khojine, A, Oikarinen, S, Hyöty, H et al.. A Coxsackievirus B vaccine protects against virus-induced diabetes in an experimental mouse model of type 1 diabetes. Diabetologia. 2018;61 (2):476-481. doi: 10.1007/s00125-017-4492-z. PubMed PMID:29151123 PubMed Central PMC6448957.
  2. Parajuli, A, Grönroos, M, Kauppi, S, Płociniczak, T, Roslund, MI, Galitskaya, P et al.. The abundance of health-associated bacteria is altered in PAH polluted soils-Implications for health in urban areas?. PLoS One. 2017;12 (11):e0187852. doi: 10.1371/journal.pone.0187852. PubMed PMID:29145477 PubMed Central PMC5690629.
  3. Lietzen, N, An, LTT, Jaakkola, MK, Kallionpää, H, Oikarinen, S, Mykkänen, J et al.. Enterovirus-associated changes in blood transcriptomic profiles of children with genetic susceptibility to type 1 diabetes. Diabetologia. 2018;61 (2):381-388. doi: 10.1007/s00125-017-4460-7. PubMed PMID:29119244 PubMed Central PMC6448961.
  4. Norris, JM, Lee, HS, Frederiksen, B, Erlund, I, Uusitalo, U, Yang, J et al.. Plasma 25-Hydroxyvitamin D Concentration and Risk of Islet Autoimmunity. Diabetes. 2018;67 (1):146-154. doi: 10.2337/db17-0802. PubMed PMID:29061729 PubMed Central PMC5741144.
  5. Kemppainen, KM, Vehik, K, Lynch, KF, Larsson, HE, Canepa, RJ, Simell, V et al.. Association Between Early-Life Antibiotic Use and the Risk of Islet or Celiac Disease Autoimmunity. JAMA Pediatr. 2017;171 (12):1217-1225. doi: 10.1001/jamapediatrics.2017.2905. PubMed PMID:29052687 PubMed Central PMC5716863.
  6. Kondrashova, A, Nurminen, N, Lehtonen, J, Hyöty, M, Toppari, J, Ilonen, J et al.. Exocrine pancreas function decreases during the progression of the beta-cell damaging process in young prediabetic children. Pediatr Diabetes. 2018;19 (3):398-402. doi: 10.1111/pedi.12592. PubMed PMID:29044779 .
  7. Elding Larsson, H, Lynch, KF, Lönnrot, M, Haller, MJ, Lernmark, Å, Hagopian, WA et al.. Pandemrix® vaccination is not associated with increased risk of islet autoimmunity or type 1 diabetes in the TEDDY study children. Diabetologia. 2018;61 (1):193-202. doi: 10.1007/s00125-017-4448-3. PubMed PMID:28990147 PubMed Central PMC5774660.
  8. Lynch, KF, Lee, HS, Törn, C, Vehik, K, Krischer, JP, Larsson, HE et al.. Gestational respiratory infections interacting with offspring HLA and CTLA-4 modifies incident β-cell autoantibodies. J Autoimmun. 2018;86 :93-103. doi: 10.1016/j.jaut.2017.09.005. PubMed PMID:28941965 PubMed Central PMC5747989.
  9. Viskari, H, Oikarinen, S, Hoppu, S, Vuorinen, T, Huhtala, H, Toppari, J et al.. Live attenuated enterovirus vaccine (OPV) is not associated with islet autoimmunity in children with genetic susceptibility to type 1 diabetes: prospective cohort study. Diabetologia. 2018;61 (1):203-209. doi: 10.1007/s00125-017-4410-4. PubMed PMID:28866779 .
  10. Köhler, M, Beyerlein, A, Vehik, K, Greven, S, Umlauf, N, Lernmark, Å et al.. Joint modeling of longitudinal autoantibody patterns and progression to type 1 diabetes: results from the TEDDY study. Acta Diabetol. 2017;54 (11):1009-1017. doi: 10.1007/s00592-017-1033-7. PubMed PMID:28856522 PubMed Central PMC5645259.
  11. Lönnrot, M, Lynch, KF, Elding Larsson, H, Lernmark, Å, Rewers, MJ, Törn, C et al.. Respiratory infections are temporally associated with initiation of type 1 diabetes autoimmunity: the TEDDY study. Diabetologia. 2017;60 (10):1931-1940. doi: 10.1007/s00125-017-4365-5. PubMed PMID:28770319 PubMed Central PMC5697762.
  12. Hyytinen, M, Savilahti, E, Virtanen, SM, Härkönen, T, Ilonen, J, Luopajärvi, K et al.. Avoidance of Cow’s Milk-Based Formula for At-Risk Infants Does Not Reduce Development of Celiac Disease: A Randomized Controlled Trial. Gastroenterology. 2017;153 (4):961-970.e3. doi: 10.1053/j.gastro.2017.06.049. PubMed PMID:28687275 .
  13. Mustonen, N, Siljander, H, Peet, A, Tillmann, V, Härkönen, T, Ilonen, J et al.. Early childhood infections precede development of beta-cell autoimmunity and type 1 diabetes in children with HLA-conferred disease risk. Pediatr Diabetes. 2018;19 (2):293-299. doi: 10.1111/pedi.12547. PubMed PMID:28597957 .
  14. Hankaniemi, MM, Laitinen, OH, Stone, VM, Sioofy-Khojine, A, Määttä, JAE, Larsson, PG et al.. Optimized production and purification of Coxsackievirus B1 vaccine and its preclinical evaluation in a mouse model. Vaccine. 2017;35 (30):3718-3725. doi: 10.1016/j.vaccine.2017.05.057. PubMed PMID:28579231 .
  15. Lin, J, Kramna, L, Autio, R, Hyöty, H, Nykter, M, Cinek, O et al.. Vipie: web pipeline for parallel characterization of viral populations from multiple NGS samples. BMC Genomics. 2017;18 (1):378. doi: 10.1186/s12864-017-3721-7. PubMed PMID:28506246 PubMed Central PMC5430618.
  16. Haghighi, M, Johnson, SB, Qian, X, Lynch, KF, Vehik, K, Huang, S et al.. Corrigendum: A Comparison of Rule-based Analysis with Regression Methods in Understanding the Risk Factors for Study Withdrawal in a Pediatric Study. Sci Rep. 2017;7 :39723. doi: 10.1038/srep39723. PubMed PMID:28462922 PubMed Central PMC5411889.
  17. Sillanpää, S, Kramna, L, Oikarinen, S, Sipilä, M, Rautiainen, M, Aittoniemi, J et al.. Next-Generation Sequencing Combined with Specific PCR Assays To Determine the Bacterial 16S rRNA Gene Profiles of Middle Ear Fluid Collected from Children with Acute Otitis Media. mSphere. ;2 (2):. doi: 10.1128/mSphere.00006-17. PubMed PMID:28357413 PubMed Central PMC5362748.
  18. Kantola, K, Hedman, L, Tanner, L, Simell, V, Mäkinen, M, Partanen, J et al.. Correction: B-Cell Responses to Human Bocaviruses 1-4: New Insights from a Childhood Follow-Up Study. PLoS One. ;12 (2):e0172078. doi: 10.1371/journal.pone.0172078. PubMed PMID:28178324 PubMed Central PMC5298275.
  19. Busse, N, Paroni, F, Richardson, SJ, Laiho, JE, Oikarinen, M, Frisk, G et al.. Detection and localization of viral infection in the pancreas of patients with type 1 diabetes using short fluorescently-labelled oligonucleotide probes. Oncotarget. 2017;8 (8):12620-12636. doi: 10.18632/oncotarget.14896. PubMed PMID:28147344 PubMed Central PMC5355040.
  20. Viisanen, T, Ihantola, EL, Näntö-Salonen, K, Hyöty, H, Nurminen, N, Selvenius, J et al.. Circulating CXCR5+PD-1+ICOS+ Follicular T Helper Cells Are Increased Close to the Diagnosis of Type 1 Diabetes in Children With Multiple Autoantibodies. Diabetes. 2017;66 (2):437-447. doi: 10.2337/db16-0714. PubMed PMID:28108610 .
  21. Campbell-Thompson, ML, Atkinson, MA, Butler, AE, Giepmans, BN, von Herrath, MG, Hyöty, H et al.. Re-addressing the 2013 consensus guidelines for the diagnosis of insulitis in human type 1 diabetes: is change necessary?. Diabetologia. 2017;60 (4):753-755. doi: 10.1007/s00125-016-4195-x. PubMed PMID:28070616 PubMed Central PMC5415083.
  22. Honkanen, H, Oikarinen, S, Nurminen, N, Laitinen, OH, Huhtala, H, Lehtonen, J et al.. Detection of enteroviruses in stools precedes islet autoimmunity by several months: possible evidence for slowly operating mechanisms in virus-induced autoimmunity. Diabetologia. 2017;60 (3):424-431. doi: 10.1007/s00125-016-4177-z. PubMed PMID:28070615 .
  23. Cinek, O, Kramna, L, Lin, J, Oikarinen, S, Kolarova, K, Ilonen, J et al.. Imbalance of bacteriome profiles within the Finnish Diabetes Prediction and Prevention study: Parallel use of 16S profiling and virome sequencing in stool samples from children with islet autoimmunity and matched controls. Pediatr Diabetes. 2017;18 (7):588-598. doi: 10.1111/pedi.12468. PubMed PMID:27860030 .
  24. Kemppainen, KM, Lynch, KF, Liu, E, Lönnrot, M, Simell, V, Briese, T et al.. Factors That Increase Risk of Celiac Disease Autoimmunity After a Gastrointestinal Infection in Early Life. Clin Gastroenterol Hepatol. 2017;15 (5):694-702.e5. doi: 10.1016/j.cgh.2016.10.033. PubMed PMID:27840181 PubMed Central PMC5576726.

Search PubMed

2016
  1. Viisanen, T, Ihantola, EL, Näntö-Salonen, K, Hyöty, H, Nurminen, N, Selvenius, J et al.. Circulating CXCR5+PD-1+ICOS+ Follicular T Helper Cells Are Increased Close to the Diagnosis of Type 1 Diabetes in Children With Multiple Autoantibodies. Diabetes. 2017;66 (2):437-447. doi: 10.2337/db16-0714. PubMed PMID:28108610 .
  2. Hodik, M, Anagandula, M, Fuxe, J, Krogvold, L, Dahl-Jørgensen, K, Hyöty, H et al.. Coxsackie-adenovirus receptor expression is enhanced in pancreas from patients with type 1 diabetes. BMJ Open Diabetes Res Care. 2016;4 (1):e000219. doi: 10.1136/bmjdrc-2016-000219. PubMed PMID:27933184 PubMed Central PMC5129002.
  3. Cinek, O, Kramna, L, Lin, J, Oikarinen, S, Kolarova, K, Ilonen, J et al.. Imbalance of bacteriome profiles within the Finnish Diabetes Prediction and Prevention study: Parallel use of 16S profiling and virome sequencing in stool samples from children with islet autoimmunity and matched controls. Pediatr Diabetes. 2017;18 (7):588-598. doi: 10.1111/pedi.12468. PubMed PMID:27860030 .
  4. Kemppainen, KM, Lynch, KF, Liu, E, Lönnrot, M, Simell, V, Briese, T et al.. Factors That Increase Risk of Celiac Disease Autoimmunity After a Gastrointestinal Infection in Early Life. Clin Gastroenterol Hepatol. 2017;15 (5):694-702.e5. doi: 10.1016/j.cgh.2016.10.033. PubMed PMID:27840181 PubMed Central PMC5576726.
  5. Seppälä, E, Sillanpää, S, Nurminen, N, Huhtala, H, Toppari, J, Ilonen, J et al.. Human enterovirus and rhinovirus infections are associated with otitis media in a prospective birth cohort study. J Clin Virol. 2016;85 :1-6. doi: 10.1016/j.jcv.2016.10.010. PubMed PMID:27780081 .
  6. Simre, K, Uibo, O, Peet, A, Tillmann, V, Kool, P, Hämäläinen, AM et al.. Exploring the risk factors for differences in the cumulative incidence of coeliac disease in two neighboring countries: the prospective DIABIMMUNE study. Dig Liver Dis. 2016;48 (11):1296-1301. doi: 10.1016/j.dld.2016.06.029. PubMed PMID:27499360 .
  7. Borges, IC, Andrade, DC, Cardoso, MR, Toppari, J, Vähä-Mäkilä, M, Ilonen, J et al.. Natural Development of Antibodies against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis Protein Antigens during the First 13 Years of Life. Clin Vaccine Immunol. 2016;23 (11):878-883. doi: 10.1128/CVI.00341-16. PubMed PMID:27581439 PubMed Central PMC5098021.
  8. Haghighi, M, Johnson, SB, Qian, X, Lynch, KF, Vehik, K, Huang, S et al.. A Comparison of Rule-based Analysis with Regression Methods in Understanding the Risk Factors for Study Withdrawal in a Pediatric Study. Sci Rep. 2016;6 :30828. doi: 10.1038/srep30828. PubMed PMID:27561809 PubMed Central PMC5000469.
  9. Sillanpää, S, Oikarinen, S, Sipilä, M, Kramna, L, Rautiainen, M, Huhtala, H et al.. Moraxella catarrhalis Might Be More Common than Expected in Acute Otitis Media in Young Finnish Children. J Clin Microbiol. 2016;54 (9):2373-9. doi: 10.1128/JCM.01146-16. PubMed PMID:27413187 PubMed Central PMC5005485.
  10. Hyöty, H. Viruses in type 1 diabetes. Pediatr Diabetes. 2016;17 Suppl 22 :56-64. doi: 10.1111/pedi.12370. PubMed PMID:27411438 .
  11. Törn, C, Liu, X, Hagopian, W, Lernmark, Å, Simell, O, Rewers, M et al.. Complement gene variants in relation to autoantibodies to beta cell specific antigens and type 1 diabetes in the TEDDY Study. Sci Rep. 2016;6 :27887. doi: 10.1038/srep27887. PubMed PMID:27306948 PubMed Central PMC4910045.
  12. Sillanpää, S, Sipilä, M, Hyöty, H, Rautiainen, M, Laranne, J. Antibiotic resistance in pathogens causing acute otitis media in Finnish children. Int J Pediatr Otorhinolaryngol. 2016;85 :91-4. doi: 10.1016/j.ijporl.2016.03.037. PubMed PMID:27240503 .
  13. Laiho, JE, Oikarinen, M, Richardson, SJ, Frisk, G, Nyalwidhe, J, Burch, TC et al.. Relative sensitivity of immunohistochemistry, multiple reaction monitoring mass spectrometry, in situ hybridization and PCR to detect Coxsackievirus B1 in A549 cells. J Clin Virol. 2016;77 :21-8. doi: 10.1016/j.jcv.2016.01.015. PubMed PMID:26875099 PubMed Central PMC5364806.
  14. Blazevic, V, Malm, M, Honkanen, H, Knip, M, Hyöty, H, Vesikari, T et al.. Development and maturation of norovirus antibodies in childhood. Microbes Infect. 2016;18 (4):263-9. doi: 10.1016/j.micinf.2015.12.004. PubMed PMID:26724451 .
  15. Mäkinen, M, Mykkänen, J, Koskinen, M, Simell, V, Veijola, R, Hyöty, H et al.. Serum 25-Hydroxyvitamin D Concentrations in Children Progressing to Autoimmunity and Clinical Type 1 Diabetes. J Clin Endocrinol Metab. 2016;101 (2):723-9. doi: 10.1210/jc.2015-3504. PubMed PMID:26695863 PubMed Central PMC4880127.
  16. Lernmark, B, Lynch, K, Baxter, J, Roth, R, Simell, T, Smith, L et al.. Participant Experiences in the Environmental Determinants of Diabetes in the Young Study: Common Reasons for Withdrawing. J Diabetes Res. 2016;2016 :2720650. doi: 10.1155/2016/2720650. PubMed PMID:26682228 PubMed Central PMC4670659.
  17. Uusitalo, U, Liu, X, Yang, J, Aronsson, CA, Hummel, S, Butterworth, M et al.. Association of Early Exposure of Probiotics and Islet Autoimmunity in the TEDDY Study. JAMA Pediatr. 2016;170 (1):20-8. doi: 10.1001/jamapediatrics.2015.2757. PubMed PMID:26552054 PubMed Central PMC4803028.
  18. Juusola, M, Parkkola, A, Härkönen, T, Siljander, H, Ilonen, J, Åkerblom, HK et al.. Positivity for Zinc Transporter 8 Autoantibodies at Diagnosis Is Subsequently Associated With Reduced β-Cell Function and Higher Exogenous Insulin Requirement in Children and Adolescents With Type 1 Diabetes. Diabetes Care. 2016;39 (1):118-21. doi: 10.2337/dc15-1027. PubMed PMID:26519333 PubMed Central PMC4876730.
  19. Andrén Aronsson, C, Lee, HS, Koletzko, S, Uusitalo, U, Yang, J, Virtanen, SM et al.. Effects of Gluten Intake on Risk of Celiac Disease: A Case-Control Study on a Swedish Birth Cohort. Clin Gastroenterol Hepatol. 2016;14 (3):403-409.e3. doi: 10.1016/j.cgh.2015.09.030. PubMed PMID:26453955 PubMed Central PMC4897964.

Search PubMed

2015
  1. Blazevic, V, Malm, M, Honkanen, H, Knip, M, Hyöty, H, Vesikari, T et al.. Development and maturation of norovirus antibodies in childhood. Microbes Infect. 2016;18 (4):263-9. doi: 10.1016/j.micinf.2015.12.004. PubMed PMID:26724451 .
  2. Mäkinen, M, Mykkänen, J, Koskinen, M, Simell, V, Veijola, R, Hyöty, H et al.. Serum 25-Hydroxyvitamin D Concentrations in Children Progressing to Autoimmunity and Clinical Type 1 Diabetes. J Clin Endocrinol Metab. 2016;101 (2):723-9. doi: 10.1210/jc.2015-3504. PubMed PMID:26695863 PubMed Central PMC4880127.
  3. Lernmark, B, Lynch, K, Baxter, J, Roth, R, Simell, T, Smith, L et al.. Participant Experiences in the Environmental Determinants of Diabetes in the Young Study: Common Reasons for Withdrawing. J Diabetes Res. 2016;2016 :2720650. doi: 10.1155/2016/2720650. PubMed PMID:26682228 PubMed Central PMC4670659.
  4. Juusola, M, Parkkola, A, Härkönen, T, Siljander, H, Ilonen, J, Åkerblom, HK et al.. Positivity for Zinc Transporter 8 Autoantibodies at Diagnosis Is Subsequently Associated With Reduced β-Cell Function and Higher Exogenous Insulin Requirement in Children and Adolescents With Type 1 Diabetes. Diabetes Care. 2016;39 (1):118-21. doi: 10.2337/dc15-1027. PubMed PMID:26519333 PubMed Central PMC4876730.
  5. Andrén Aronsson, C, Lee, HS, Koletzko, S, Uusitalo, U, Yang, J, Virtanen, SM et al.. Effects of Gluten Intake on Risk of Celiac Disease: A Case-Control Study on a Swedish Birth Cohort. Clin Gastroenterol Hepatol. 2016;14 (3):403-409.e3. doi: 10.1016/j.cgh.2015.09.030. PubMed PMID:26453955 PubMed Central PMC4897964.
  6. Kantola, K, Hedman, L, Tanner, L, Simell, V, Mäkinen, M, Partanen, J et al.. B-Cell Responses to Human Bocaviruses 1-4: New Insights from a Childhood Follow-Up Study. PLoS One. 2015;10 (9):e0139096. doi: 10.1371/journal.pone.0139096. PubMed PMID:26418064 PubMed Central PMC4587975.
  7. Kondrashova, A, Nurminen, N, Patrikainen, M, Huhtala, H, Lehtonen, J, Toppari, J et al.. Influenza A virus antibodies show no association with pancreatic islet autoantibodies in children genetically predisposed to type 1 diabetes. Diabetologia. 2015;58 (11):2592-5. doi: 10.1007/s00125-015-3723-4. PubMed PMID:26253765 .
  8. Laiho, JE, Oikarinen, S, Oikarinen, M, Larsson, PG, Stone, VM, Hober, D et al.. Application of bioinformatics in probe design enables detection of enteroviruses on different taxonomic levels by advanced in situ hybridization technology. J Clin Virol. 2015;69 :165-71. doi: 10.1016/j.jcv.2015.06.085. PubMed PMID:26209400 .
  9. Blazevic, V, Malm, M, Salminen, M, Oikarinen, S, Hyöty, H, Veijola, R et al.. Multiple consecutive norovirus infections in the first 2 years of life. Eur J Pediatr. 2015;174 (12):1679-83. doi: 10.1007/s00431-015-2591-8. PubMed PMID:26152345 PubMed Central PMC4662724.
  10. Almasi, S, Aliparasti, MR, Aliasgarzadeh, A, Abd-Nikfarjam, B, Hyöty, H, Knip, M et al.. Investigation of CTLA-4-318C/T gene polymorphism in cases with type 1 diabetes of Azerbaijan, Northwest Iran. Immunol Lett. 2015;166 (2):134-9. doi: 10.1016/j.imlet.2015.05.021. PubMed PMID:26051683 .
  11. Peet, A, Hämäläinen, AM, Kool, P, Ilonen, J, Knip, M, Tillmann, V et al.. Circulating IGF1 and IGFBP3 in relation to the development of β-cell autoimmunity in young children. Eur J Endocrinol. 2015;173 (2):129-37. doi: 10.1530/EJE-14-1078. PubMed PMID:25947142 .
  12. Nurminen, N, Juuti, R, Oikarinen, S, Fan, YM, Lehto, KM, Mangani, C et al.. High-throughput multiplex quantitative polymerase chain reaction method for Giardia lamblia and Cryptosporidium species detection in stool samples. Am J Trop Med Hyg. 2015;92 (6):1222-6. doi: 10.4269/ajtmh.15-0054. PubMed PMID:25918202 PubMed Central PMC4458829.
  13. Lönnrot, M, Lynch, K, Larsson, HE, Lernmark, Å, Rewers, M, Hagopian, W et al.. A method for reporting and classifying acute infectious diseases in a prospective study of young children: TEDDY. BMC Pediatr. 2015;15 :24. doi: 10.1186/s12887-015-0333-8. PubMed PMID:25884839 PubMed Central PMC4377063.
  14. Acevedo, N, Reinius, LE, Vitezic, M, Fortino, V, Söderhäll, C, Honkanen, H et al.. Age-associated DNA methylation changes in immune genes, histone modifiers and chromatin remodeling factors within 5 years after birth in human blood leukocytes. Clin Epigenetics. 2015;7 :34. doi: 10.1186/s13148-015-0064-6. PubMed PMID:25874017 PubMed Central PMC4396570.
  15. Agardh, D, Lee, HS, Kurppa, K, Simell, V, Aronsson, CA, Jörneus, O et al.. Clinical features of celiac disease: a prospective birth cohort. Pediatrics. 2015;135 (4):627-34. doi: 10.1542/peds.2014-3675. PubMed PMID:25733751 PubMed Central PMC4379464.
  16. Kramná, L, Kolářová, K, Oikarinen, S, Pursiheimo, JP, Ilonen, J, Simell, O et al.. Gut virome sequencing in children with early islet autoimmunity. Diabetes Care. 2015;38 (5):930-3. doi: 10.2337/dc14-2490. PubMed PMID:25678103 .
  17. Steck, AK, Vehik, K, Bonifacio, E, Lernmark, A, Ziegler, AG, Hagopian, WA et al.. Predictors of Progression From the Appearance of Islet Autoantibodies to Early Childhood Diabetes: The Environmental Determinants of Diabetes in the Young (TEDDY). Diabetes Care. 2015;38 (5):808-13. doi: 10.2337/dc14-2426. PubMed PMID:25665818 PubMed Central PMC4407751.
  18. Kostic, AD, Gevers, D, Siljander, H, Vatanen, T, Hyötyläinen, T, Hämäläinen, AM et al.. The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes. Cell Host Microbe. 2015;17 (2):260-73. doi: 10.1016/j.chom.2015.01.001. PubMed PMID:25662751 PubMed Central PMC4689191.
  19. Moulder, R, Bhosale, SD, Erkkilä, T, Laajala, E, Salmi, J, Nguyen, EV et al.. Serum proteomes distinguish children developing type 1 diabetes in a cohort with HLA-conferred susceptibility. Diabetes. 2015;64 (6):2265-78. doi: 10.2337/db14-0983. PubMed PMID:25616278 .
  20. Aronsson, CA, Lee, HS, Liu, E, Uusitalo, U, Hummel, S, Yang, J et al.. Age at gluten introduction and risk of celiac disease. Pediatrics. 2015;135 (2):239-45. doi: 10.1542/peds.2014-1787. PubMed PMID:25601977 PubMed Central PMC4306795.
  21. Kemppainen, KM, Ardissone, AN, Davis-Richardson, AG, Fagen, JR, Gano, KA, León-Novelo, LG et al.. Early childhood gut microbiomes show strong geographic differences among subjects at high risk for type 1 diabetes. Diabetes Care. 2015;38 (2):329-32. doi: 10.2337/dc14-0850. PubMed PMID:25519450 PubMed Central PMC4302256.
  22. Reinert-Hartwall, L, Honkanen, J, Salo, HM, Nieminen, JK, Luopajärvi, K, Härkönen, T et al.. Th1/Th17 plasticity is a marker of advanced β cell autoimmunity and impaired glucose tolerance in humans. J Immunol. 2015;194 (1):68-75. doi: 10.4049/jimmunol.1401653. PubMed PMID:25480564 PubMed Central PMC4273995.
  23. Sillanpää, S, Oikarinen, S, Sipilä, M, Seppälä, E, Nurminen, N, Rautiainen, M et al.. Human parechovirus as a minor cause of acute otitis media in children. J Clin Virol. 2015;62 :106-9. doi: 10.1016/j.jcv.2014.11.002. PubMed PMID:25464964 .
  24. Krogvold, L, Edwin, B, Buanes, T, Frisk, G, Skog, O, Anagandula, M et al.. Detection of a low-grade enteroviral infection in the islets of langerhans of living patients newly diagnosed with type 1 diabetes. Diabetes. 2015;64 (5):1682-7. doi: 10.2337/db14-1370. PubMed PMID:25422108 .
  25. Törn, C, Hadley, D, Lee, HS, Hagopian, W, Lernmark, Å, Simell, O et al.. Role of Type 1 Diabetes-Associated SNPs on Risk of Autoantibody Positivity in the TEDDY Study. Diabetes. 2015;64 (5):1818-29. doi: 10.2337/db14-1497. PubMed PMID:25422107 PubMed Central PMC4407865.
  26. Larsson, PG, Lakshmikanth, T, Laitinen, OH, Utorova, R, Jacobson, S, Oikarinen, M et al.. A preclinical study on the efficacy and safety of a new vaccine against Coxsackievirus B1 reveals no risk for accelerated diabetes development in mouse models. Diabetologia. 2015;58 (2):346-54. doi: 10.1007/s00125-014-3436-0. PubMed PMID:25370797 .
  27. Roth, R, Lynch, K, Lernmark, B, Baxter, J, Simell, T, Smith, L et al.. Maternal anxiety about a child’s diabetes risk in the TEDDY study: the potential role of life stress, postpartum depression, and risk perception. Pediatr Diabetes. 2015;16 (4):287-98. doi: 10.1111/pedi.12168. PubMed PMID:25082392 PubMed Central PMC4312746.

Search PubMed