Publications

2021

  1. Stone, VM, Butrym, M, Hankaniemi, MM, Sioofy-Khojine, AB, Hytönen, VP, Hyöty, H et al.. Coxsackievirus B Vaccines Prevent Infection-Accelerated Diabetes in NOD Mice and Have No Disease-Inducing Effect. Diabetes. 2021; :. doi: 10.2337/db21-0193. PubMed PMID:34497136 .
  2. Nevalainen, J, Datta, S, Toppari, J, Ilonen, J, Hyöty, H, Veijola, R et al.. Frailty modeling under a selective sampling protocol: an application to type 1 diabetes related autoantibodies. Stat Med. 2021; :. doi: 10.1002/sim.9190. PubMed PMID:34496070 .
  3. Roslund, MI, Puhakka, R, Nurminen, N, Oikarinen, S, Siter, N, Grönroos, M et al.. Long-term biodiversity intervention shapes health-associated commensal microbiota among urban day-care children. Environ Int. 2021;157 :106811. doi: 10.1016/j.envint.2021.106811. PubMed PMID:34403882 .
  4. Oikarinen, S, Krogvold, L, Edwin, B, Buanes, T, Korsgren, O, Laiho, JE et al.. Characterisation of enterovirus RNA detected in the pancreas and other specimens of live patients with newly diagnosed type 1 diabetes in the DiViD study. Diabetologia. 2021;64 (11):2491-2501. doi: 10.1007/s00125-021-05525-0. PubMed PMID:34390364 .
  5. Palmu, T, Lehtonen, J, Korhonen, L, Virtanen, SM, Niemelä, O, Toppari, J et al.. Association of different enteroviruses with atopy and allergic diseases in early childhood. Pediatr Allergy Immunol. 2021; :. doi: 10.1111/pai.13577. PubMed PMID:34219290 .
  6. Haahtela, T, Alenius, H, Lehtimäki, J, Sinkkonen, A, Fyhrquist, N, Hyöty, H et al.. Immunological resilience and biodiversity for prevention of allergic diseases and asthma. Allergy. 2021; :. doi: 10.1111/all.14895. PubMed PMID:33959980 .
  7. Nurminen, N, Cerrone, D, Lehtonen, J, Parajuli, A, Roslund, M, Lönnrot, M et al.. Land Cover of Early Life Environment Modulates the Risk of Type 1 Diabetes. Diabetes Care. 2021; :. doi: 10.2337/dc20-1719. PubMed PMID:33952607 PubMed Central PMC8323192.
  8. Saarenpää, M, Roslund, MI, Puhakka, R, Grönroos, M, Parajuli, A, Hui, N et al.. Do Rural Second Homes Shape Commensal Microbiota of Urban Dwellers? A Pilot Study among Urban Elderly in Finland. Int J Environ Res Public Health. 2021;18 (7):. doi: 10.3390/ijerph18073742. PubMed PMID:33918486 PubMed Central PMC8038225.
  9. Ruohtula, T, Kondrashova, A, Lehtonen, J, Oikarinen, S, Hämäläinen, AM, Niemelä, O et al.. Immunomodulatory Effects of Rhinovirus and Enterovirus Infections During the First Year of Life. Front Immunol. 2020;11 :567046. doi: 10.3389/fimmu.2020.567046. PubMed PMID:33643278 PubMed Central PMC7905218.
  10. Bonifacio, E, Weiß, A, Winkler, C, Hippich, M, Rewers, MJ, Toppari, J et al.. An Age-Related Exponential Decline in the Risk of Multiple Islet Autoantibody Seroconversion During Childhood. Diabetes Care. 2021; :. doi: 10.2337/dc20-2122. PubMed PMID:33627366 .
  11. Oikarinen, M, Puustinen, L, Lehtonen, J, Hakola, L, Simell, S, Toppari, J et al.. Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study. Front Immunol. 2020;11 :604529. doi: 10.3389/fimmu.2020.604529. PubMed PMID:33603739 PubMed Central PMC7884453.
  12. Hakola, L, Erlund, I, Cuthbertson, D, Miettinen, ME, Autio, R, Nucci, AM et al.. Serum fatty acids and risk of developing islet autoimmunity: A nested case-control study within the TRIGR birth cohort. Pediatr Diabetes. 2021;22 (4):577-585. doi: 10.1111/pedi.13189. PubMed PMID:33543815 .
  13. Maleta, K, Fan, YM, Luoma, J, Ashorn, U, Bendabenda, J, Dewey, KG et al.. Infections and systemic inflammation are associated with lower plasma concentration of insulin-like growth factor I among Malawian children. Am J Clin Nutr. 2021;113 (2):380-390. doi: 10.1093/ajcn/nqaa327. PubMed PMID:33381802 PubMed Central PMC7851819.
  14. Vari, HK, Roslund, MI, Oikarinen, S, Nurminen, N, Puhakka, R, Parajuli, A et al.. Associations between land cover categories, gaseous PAH levels in ambient air and endocrine signaling predicted from gut bacterial metagenome of the elderly. Chemosphere. 2021;265 :128965. doi: 10.1016/j.chemosphere.2020.128965. PubMed PMID:33248729 .
  15. Liu, Z, Fan, YM, Ashorn, P, Cheung, YB, Hallamaa, L, Hyöty, H et al.. Faecal regenerating 1B protein concentration is not associated with child growth in rural Malawi. J Paediatr Child Health. 2021;57 (3):388-394. doi: 10.1111/jpc.15231. PubMed PMID:33112481 PubMed Central PMC8048694.

Search PubMed

2020

  1. Ruohtula, T, Kondrashova, A, Lehtonen, J, Oikarinen, S, Hämäläinen, AM, Niemelä, O et al.. Immunomodulatory Effects of Rhinovirus and Enterovirus Infections During the First Year of Life. Front Immunol. 2020;11 :567046. doi: 10.3389/fimmu.2020.567046. PubMed PMID:33643278 PubMed Central PMC7905218.
  2. Oikarinen, M, Puustinen, L, Lehtonen, J, Hakola, L, Simell, S, Toppari, J et al.. Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study. Front Immunol. 2020;11 :604529. doi: 10.3389/fimmu.2020.604529. PubMed PMID:33603739 PubMed Central PMC7884453.
  3. Salmikangas, S, Laiho, JE, Kalander, K, Laajala, M, Honkimaa, A, Shanina, I et al.. Detection of Viral -RNA and +RNA Strands in Enterovirus-Infected Cells and Tissues. Microorganisms. 2020;8 (12):. doi: 10.3390/microorganisms8121928. PubMed PMID:33291747 PubMed Central PMC7761939.
  4. Vari, HK, Roslund, MI, Oikarinen, S, Nurminen, N, Puhakka, R, Parajuli, A et al.. Associations between land cover categories, gaseous PAH levels in ambient air and endocrine signaling predicted from gut bacterial metagenome of the elderly. Chemosphere. 2021;265 :128965. doi: 10.1016/j.chemosphere.2020.128965. PubMed PMID:33248729 .
  5. Honkimaa, A, Kimura, B, Sioofy-Khojine, AB, Lin, J, Laiho, J, Oikarinen, S et al.. Genetic Adaptation of Coxsackievirus B1 during Persistent Infection in Pancreatic Cells. Microorganisms. 2020;8 (11):. doi: 10.3390/microorganisms8111790. PubMed PMID:33203081 PubMed Central PMC7697981.
  6. Liu, Z, Fan, YM, Ashorn, P, Cheung, YB, Hallamaa, L, Hyöty, H et al.. Faecal regenerating 1B protein concentration is not associated with child growth in rural Malawi. J Paediatr Child Health. 2021;57 (3):388-394. doi: 10.1111/jpc.15231. PubMed PMID:33112481 PubMed Central PMC8048694.
  7. Roslund, MI, Puhakka, R, Grönroos, M, Nurminen, N, Oikarinen, S, Gazali, AM et al.. Biodiversity intervention enhances immune regulation and health-associated commensal microbiota among daycare children. Sci Adv. 2020;6 (42):. doi: 10.1126/sciadv.aba2578. PubMed PMID:33055153 PubMed Central PMC7556828.
  8. Saarinen, NVV, Lehtonen, J, Veijola, R, Lempainen, J, Knip, M, Hyöty, H et al.. Correction: Saarinen, N.V.V., et al. Multiplexed High-Throughput Serological Assay for Human Enteroviruses. Microorganismis 2020, 8, 963. Microorganisms. 2020;8 (9):. doi: 10.3390/microorganisms8091426. PubMed PMID:32957450 PubMed Central PMC7563745.
  9. Hankaniemi, MM, Baikoghli, MA, Stone, VM, Xing, L, Väätäinen, O, Soppela, S et al.. Structural Insight into CVB3-VLP Non-Adjuvanted Vaccine. Microorganisms. 2020;8 (9):. doi: 10.3390/microorganisms8091287. PubMed PMID:32846899 PubMed Central PMC7565060.
  10. Sinisalu, L, Sen, P, Salihović, S, Virtanen, SM, Hyöty, H, Ilonen, J et al.. Early-life exposure to perfluorinated alkyl substances modulates lipid metabolism in progression to celiac disease. Environ Res. 2020;188 :109864. doi: 10.1016/j.envres.2020.109864. PubMed PMID:32846648 .
  11. Ferrat, LA, Vehik, K, Sharp, SA, Lernmark, Å, Rewers, MJ, She, JX et al.. A combined risk score enhances prediction of type 1 diabetes among susceptible children. Nat Med. 2020;26 (8):1247-1255. doi: 10.1038/s41591-020-0930-4. PubMed PMID:32770166 PubMed Central PMC7556983.
  12. Oikarinen, M, Bertolet, L, Toniolo, A, Oikarinen, S, Laiho, JE, Pugliese, A et al.. Differential Detection of Encapsidated versus Unencapsidated Enterovirus RNA in Samples Containing Pancreatic Enzymes-Relevance for Diabetes Studies. Viruses. 2020;12 (7):. doi: 10.3390/v12070747. PubMed PMID:32664501 PubMed Central PMC7411921.
  13. Vehik, K, Bonifacio, E, Lernmark, Å, Yu, L, Williams, A, Schatz, D et al.. Hierarchical Order of Distinct Autoantibody Spreading and Progression to Type 1 Diabetes in the TEDDY Study. Diabetes Care. 2020;43 (9):2066-2073. doi: 10.2337/dc19-2547. PubMed PMID:32641373 PubMed Central PMC7440899.
  14. Saarinen, NVV, Lehtonen, J, Veijola, R, Lempainen, J, Knip, M, Hyöty, H et al.. Multiplexed High-Throughput Serological Assay for Human Enteroviruses. Microorganisms. 2020;8 (6):. doi: 10.3390/microorganisms8060963. PubMed PMID:32604930 PubMed Central PMC7355947.
  15. Stone, VM, Hankaniemi, MM, Laitinen, OH, Sioofy-Khojine, AB, Lin, A, Diaz Lozano, IM et al.. A hexavalent Coxsackievirus B vaccine is highly immunogenic and has a strong protective capacity in mice and nonhuman primates. Sci Adv. 2020;6 (19):eaaz2433. doi: 10.1126/sciadv.aaz2433. PubMed PMID:32494709 PubMed Central PMC7202868.
  16. Honkimaa, A, Sioofy-Khojine, AB, Oikarinen, S, Bertin, A, Hober, D, Hyöty, H et al.. Eradication of persistent coxsackievirus B infection from a pancreatic cell line with clinically used antiviral drugs. J Clin Virol. 2020;128 :104334. doi: 10.1016/j.jcv.2020.104334. PubMed PMID:32450550 .
  17. Sane, F, Bertin, A, Sioofy-Khojine, AB, Oikarinen, S, Alidjinou, EK, Veijola, R et al.. Enhancing and neutralizing anti-coxsackievirus activities in serum samples from patients prior to development of type 1 diabetes. Diabetes Metab Res Rev. 2020;36 (6):e3305. doi: 10.1002/dmrr.3305. PubMed PMID:32118346 .
  18. Seppälä, EM, Oikarinen, S, Lehtonen, JP, Neupane, S, Honkanen, H, Tyni, I et al.. Association of Picornavirus Infections With Acute Otitis Media in a Prospective Birth Cohort Study. J Infect Dis. 2020;222 (2):324-332. doi: 10.1093/infdis/jiaa087. PubMed PMID:32108877 .
  19. Sen, P, Dickens, AM, López-Bascón, MA, Lindeman, T, Kemppainen, E, Lamichhane, S et al.. Metabolic alterations in immune cells associate with progression to type 1 diabetes. Diabetologia. 2020;63 (5):1017-1031. doi: 10.1007/s00125-020-05107-6. PubMed PMID:32043185 PubMed Central PMC7145788.
  20. Li, Q, Parikh, H, Butterworth, MD, Lernmark, Å, Hagopian, W, Rewers, M et al.. Longitudinal Metabolome-Wide Signals Prior to the Appearance of a First Islet Autoantibody in Children Participating in the TEDDY Study. Diabetes. 2020;69 (3):465-476. doi: 10.2337/db19-0756. PubMed PMID:32029481 PubMed Central PMC7034190.
  21. Parajuli, A, Hui, N, Puhakka, R, Oikarinen, S, Grönroos, M, Selonen, VAO et al.. Yard vegetation is associated with gut microbiota composition. Sci Total Environ. 2020;713 :136707. doi: 10.1016/j.scitotenv.2020.136707. PubMed PMID:32019041 .
  22. Saarinen, NVV, Stone, VM, Hankaniemi, MM, Mazur, MA, Vuorinen, T, Flodström-Tullberg, M et al.. Antibody Responses against Enterovirus Proteases are Potential Markers for an Acute Infection. Viruses. 2020;12 (1):. doi: 10.3390/v12010078. PubMed PMID:31936473 PubMed Central PMC7020046.
  23. Miettinen, ME, Niinistö, S, Erlund, I, Cuthbertson, D, Nucci, AM, Honkanen, J et al.. Serum 25-hydroxyvitamin D concentration in childhood and risk of islet autoimmunity and type 1 diabetes: the TRIGR nested case-control ancillary study. Diabetologia. 2020;63 (4):780-787. doi: 10.1007/s00125-019-05077-4. PubMed PMID:31912198 PubMed Central PMC7054378.
  24. Liu, X, Vehik, K, Huang, Y, Elding Larsson, H, Toppari, J, Ziegler, AG et al.. Distinct Growth Phases in Early Life Associated With the Risk of Type 1 Diabetes: The TEDDY Study. Diabetes Care. 2020;43 (3):556-562. doi: 10.2337/dc19-1670. PubMed PMID:31896601 PubMed Central PMC7035588.
  25. Ojwang, V, Nwaru, BI, Takkinen, HM, Kaila, M, Niemelä, O, Haapala, AM et al.. Early exposure to cats, dogs and farm animals and the risk of childhood asthma and allergy. Pediatr Allergy Immunol. 2020;31 (3):265-272. doi: 10.1111/pai.13186. PubMed PMID:31829464 .
  26. Lindfors, K, Lin, J, Lee, HS, Hyöty, H, Nykter, M, Kurppa, K et al.. Metagenomics of the faecal virome indicate a cumulative effect of enterovirus and gluten amount on the risk of coeliac disease autoimmunity in genetically at risk children: the TEDDY study. Gut. 2020;69 (8):1416-1422. doi: 10.1136/gutjnl-2019-319809. PubMed PMID:31744911 PubMed Central PMC7234892.
  27. Sioofy-Khojine, AB, Honkimaa, A, Hyöty, H. A preclinical assessment to repurpose drugs to target type 1 diabetes-associated type B coxsackieviruses. Diabet Med. 2020;37 (11):1849-1853. doi: 10.1111/dme.14175. PubMed PMID:31705692 .

Search PubMed

2019
  1. Vehik, K, Lynch, KF, Wong, MC, Tian, X, Ross, MC, Gibbs, RA et al.. Prospective virome analyses in young children at increased genetic risk for type 1 diabetes. Nat Med. 2019;25 (12):1865-1872. doi: 10.1038/s41591-019-0667-0. PubMed PMID:31792456 PubMed Central PMC6898786.
  2. Lindfors, K, Lin, J, Lee, HS, Hyöty, H, Nykter, M, Kurppa, K et al.. Metagenomics of the faecal virome indicate a cumulative effect of enterovirus and gluten amount on the risk of coeliac disease autoimmunity in genetically at risk children: the TEDDY study. Gut. 2020;69 (8):1416-1422. doi: 10.1136/gutjnl-2019-319809. PubMed PMID:31744911 PubMed Central PMC7234892.
  3. Sioofy-Khojine, AB, Honkimaa, A, Hyöty, H. A preclinical assessment to repurpose drugs to target type 1 diabetes-associated type B coxsackieviruses. Diabet Med. 2020;37 (11):1849-1853. doi: 10.1111/dme.14175. PubMed PMID:31705692 .
  4. Johnson, RK, Vanderlinden, L, DeFelice, BC, Kechris, K, Uusitalo, U, Fiehn, O et al.. Metabolite-related dietary patterns and the development of islet autoimmunity. Sci Rep. 2019;9 (1):14819. doi: 10.1038/s41598-019-51251-4. PubMed PMID:31616039 PubMed Central PMC6794249.
  5. Heinimäki, S, Hankaniemi, MM, Sioofy-Khojine, AB, Laitinen, OH, Hyöty, H, Hytönen, VP et al.. Combination of three virus-derived nanoparticles as a vaccine against enteric pathogens; enterovirus, norovirus and rotavirus. Vaccine. 2019;37 (51):7509-7518. doi: 10.1016/j.vaccine.2019.09.072. PubMed PMID:31585726 .
  6. Frank, NM, Lynch, KF, Uusitalo, U, Yang, J, Lönnrot, M, Virtanen, SM et al.. The relationship between breastfeeding and reported respiratory and gastrointestinal infection rates in young children. BMC Pediatr. 2019;19 (1):339. doi: 10.1186/s12887-019-1693-2. PubMed PMID:31533753 PubMed Central PMC6749679.
  7. Hankaniemi, MM, Stone, VM, Andrejeff, T, Heinimäki, S, Sioofy-Khojine, AB, Marjomäki, V et al.. Formalin treatment increases the stability and immunogenicity of coxsackievirus B1 VLP vaccine. Antiviral Res. 2019;171 :104595. doi: 10.1016/j.antiviral.2019.104595. PubMed PMID:31491431 .
  8. Hankaniemi, MM, Stone, VM, Sioofy-Khojine, AB, Heinimäki, S, Marjomäki, V, Hyöty, H et al.. A comparative study of the effect of UV and formalin inactivation on the stability and immunogenicity of a Coxsackievirus B1 vaccine. Vaccine. 2019;37 (40):5962-5971. doi: 10.1016/j.vaccine.2019.08.037. PubMed PMID:31471148 .
  9. Lamichhane, S, Kemppainen, E, Trošt, K, Siljander, H, Hyöty, H, Ilonen, J et al.. Circulating metabolites in progression to islet autoimmunity and type 1 diabetes. Diabetologia. 2019;62 (12):2287-2297. doi: 10.1007/s00125-019-04980-0. PubMed PMID:31444528 PubMed Central PMC6861356.
  10. Lietzén, N, Hirvonen, K, Honkimaa, A, Buchacher, T, Laiho, JE, Oikarinen, S et al.. Coxsackievirus B Persistence Modifies the Proteome and the Secretome of Pancreatic Ductal Cells. iScience. 2019;19 :340-357. doi: 10.1016/j.isci.2019.07.040. PubMed PMID:31404834 PubMed Central PMC6699423.
  11. Hui, N, Parajuli, A, Puhakka, R, Grönroos, M, Roslund, MI, Vari, HK et al.. Temporal variation in indoor transfer of dirt-associated environmental bacteria in agricultural and urban areas. Environ Int. 2019;132 :105069. doi: 10.1016/j.envint.2019.105069. PubMed PMID:31400602 .
  12. Edwards, RA, Vega, AA, Norman, HM, Ohaeri, M, Levi, K, Dinsdale, EA et al.. Global phylogeography and ancient evolution of the widespread human gut virus crAssphage. Nat Microbiol. 2019;4 (10):1727-1736. doi: 10.1038/s41564-019-0494-6. PubMed PMID:31285584 PubMed Central PMC7440971.
  13. Roslund, MI, Rantala, S, Oikarinen, S, Puhakka, R, Hui, N, Parajuli, A et al.. Endocrine disruption and commensal bacteria alteration associated with gaseous and soil PAH contamination among daycare children. Environ Int. 2019;130 :104894. doi: 10.1016/j.envint.2019.06.004. PubMed PMID:31220749 .
  14. Mustonen, N, Siljander, H, Peet, A, Tillmann, V, Härkönen, T, Ilonen, J et al.. Early childhood infections and the use of antibiotics and antipyretic-analgesics in Finland, Estonia and Russian Karelia. Acta Paediatr. 2019;108 (11):2075-2082. doi: 10.1111/apa.14874. PubMed PMID:31132164 .
  15. Sen, P, Carlsson, C, Virtanen, SM, Simell, S, Hyöty, H, Ilonen, J et al.. Persistent Alterations in Plasma Lipid Profiles Before Introduction of Gluten in the Diet Associated With Progression to Celiac Disease. Clin Transl Gastroenterol. 2019;10 (5):1-10. doi: 10.14309/ctg.0000000000000044. PubMed PMID:31082858 PubMed Central PMC6602763.
  16. Lehto, KM, Fan, YM, Oikarinen, S, Nurminen, N, Hallamaa, L, Juuti, R et al.. Presence of Giardia lamblia in stools of six- to 18-month old asymptomatic Malawians is associated with children’s growth failure. Acta Paediatr. 2019;108 (10):1833-1840. doi: 10.1111/apa.14832. PubMed PMID:31038225 PubMed Central PMC6790611.
  17. Dunne, JL, Richardson, SJ, Atkinson, MA, Craig, ME, Dahl-Jørgensen, K, Flodström-Tullberg, M et al.. Large enteroviral vaccination studies to prevent type 1 diabetes should be well founded and rely on scientific evidence. Reply to Skog O, Klingel K, Roivainen M et al [letter]. Diabetologia. 2019;62 (6):1100-1103. doi: 10.1007/s00125-019-4873-6. PubMed PMID:31016358 .
  18. Krischer, JP, Liu, X, Vehik, K, Akolkar, B, Hagopian, WA, Rewers, MJ et al.. Predicting Islet Cell Autoimmunity and Type 1 Diabetes: An 8-Year TEDDY Study Progress Report. Diabetes Care. 2019;42 (6):1051-1060. doi: 10.2337/dc18-2282. PubMed PMID:30967432 PubMed Central PMC6609953.
  19. Simre, K, Uibo, O, Peet, A, Puustinen, L, Oikarainen, S, Tamminen, K et al.. Early-life exposure to common virus infections did not differ between coeliac disease patients and controls. Acta Paediatr. 2019;108 (9):1709-1716. doi: 10.1111/apa.14791. PubMed PMID:30896051 .
  20. Fan, YM, Oikarinen, S, Lehto, KM, Nurminen, N, Juuti, R, Mangani, C et al.. High prevalence of selected viruses and parasites and their predictors in Malawian children. Epidemiol Infect. 2019;147 :e90. doi: 10.1017/S0950268819000025. PubMed PMID:30869004 PubMed Central PMC6521582.
  21. Korhonen, L, Oikarinen, S, Lehtonen, J, Mustonen, N, Tyni, I, Niemelä, O et al.. Rhinoviruses in infancy and risk of immunoglobulin E sensitization. J Med Virol. 2019;91 (8):1470-1478. doi: 10.1002/jmv.25455. PubMed PMID:30866076 .
  22. Malm, M, Hyöty, H, Knip, M, Vesikari, T, Blazevic, V. Development of T cell immunity to norovirus and rotavirus in children under five years of age. Sci Rep. 2019;9 (1):3199. doi: 10.1038/s41598-019-39840-9. PubMed PMID:30824789 PubMed Central PMC6397277.
  23. Roth, R, Lynch, K, Hyöty, H, Lönnrot, M, Driscoll, KA, Bennett Johnson, S et al.. The association between stressful life events and respiratory infections during the first 4 years of life: The Environmental Determinants of Diabetes in the Young study. Stress Health. 2019;35 (3):289-303. doi: 10.1002/smi.2861. PubMed PMID:30768831 PubMed Central PMC6697245.
  24. Dunne, JL, Richardson, SJ, Atkinson, MA, Craig, ME, Dahl-Jørgensen, K, Flodström-Tullberg, M et al.. Rationale for enteroviral vaccination and antiviral therapies in human type 1 diabetes. Diabetologia. 2019;62 (5):744-753. doi: 10.1007/s00125-019-4811-7. PubMed PMID:30675626 PubMed Central PMC6450860.
  25. Lamichhane, S, Ahonen, L, Dyrlund, TS, Dickens, AM, Siljander, H, Hyöty, H et al.. Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes. Biomolecules. 2019;9 (1):. doi: 10.3390/biom9010033. PubMed PMID:30669674 PubMed Central PMC6359525.
  26. Mäkinen, M, Löyttyniemi, E, Koskinen, M, Vähä-Mäkilä, M, Siljander, H, Nurmio, M et al.. Serum 25-Hydroxyvitamin D Concentrations at Birth in Children Screened for HLA-DQB1 Conferred Risk for Type 1 Diabetes. J Clin Endocrinol Metab. 2019;104 (6):2277-2285. doi: 10.1210/jc.2018-02094. PubMed PMID:30657906 PubMed Central PMC6489691.
  27. Hippich, M, Beyerlein, A, Hagopian, WA, Krischer, JP, Vehik, K, Knoop, J et al.. Genetic Contribution to the Divergence in Type 1 Diabetes Risk Between Children From the General Population and Children From Affected Families. Diabetes. 2019;68 (4):847-857. doi: 10.2337/db18-0882. PubMed PMID:30655385 PubMed Central PMC6425872.
  28. Jääskeläinen, AJ, Nurminen, N, Kolehmainen, P, Smura, T, Tauriainen, S, Toppari, J et al.. No Association Between Ljungan Virus Seropositivity and the Beta-cell Damaging Process in the Finnish Type 1 Diabetes Prediction and Prevention Study Cohort. Pediatr Infect Dis J. 2019;38 (3):314-316. doi: 10.1097/INF.0000000000002201. PubMed PMID:30346370 .
  29. Ekman, I, Vuorinen, T, Knip, M, Veijola, R, Toppari, J, Hyöty, H et al.. Early childhood CMV infection may decelerate the progression to clinical type 1 diabetes. Pediatr Diabetes. 2019;20 (1):73-77. doi: 10.1111/pedi.12788. PubMed PMID:30338642 .
  30. Endesfelder, D, Zu Castell, W, Bonifacio, E, Rewers, M, Hagopian, WA, She, JX et al.. Time-Resolved Autoantibody Profiling Facilitates Stratification of Preclinical Type 1 Diabetes in Children. Diabetes. 2019;68 (1):119-130. doi: 10.2337/db18-0594. PubMed PMID:30305370 PubMed Central PMC6302536.
  31. Grönroos, M, Parajuli, A, Laitinen, OH, Roslund, MI, Vari, HK, Hyöty, H et al.. Short-term direct contact with soil and plant materials leads to an immediate increase in diversity of skin microbiota. Microbiologyopen. 2019;8 (3):e00645. doi: 10.1002/mbo3.645. PubMed PMID:29808965 PubMed Central PMC6436432.

Search PubMed

2018
  1. Hyöty, H, Leon, F, Knip, M. Developing a vaccine for type 1 diabetes by targeting coxsackievirus B. Expert Rev Vaccines. 2018;17 (12):1071-1083. doi: 10.1080/14760584.2018.1548281. PubMed PMID:30449209 .
  2. Lamichhane, S, Ahonen, L, Dyrlund, TS, Siljander, H, Hyöty, H, Ilonen, J et al.. A longitudinal plasma lipidomics dataset from children who developed islet autoimmunity and type 1 diabetes. Sci Data. 2018;5 :180250. doi: 10.1038/sdata.2018.250. PubMed PMID:30422126 PubMed Central PMC6233478.
  3. Stewart, CJ, Ajami, NJ, O’Brien, JL, Hutchinson, DS, Smith, DP, Wong, MC et al.. Temporal development of the gut microbiome in early childhood from the TEDDY study. Nature. 2018;562 (7728):583-588. doi: 10.1038/s41586-018-0617-x. PubMed PMID:30356187 PubMed Central PMC6415775.
  4. Rewers, M, Hyöty, H, Lernmark, Å, Hagopian, W, She, JX, Schatz, D et al.. The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update. Curr Diab Rep. 2018;18 (12):136. doi: 10.1007/s11892-018-1113-2. PubMed PMID:30353256 PubMed Central PMC6415767.
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Search PubMed

2017
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2016
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2015
  1. Blazevic, V, Malm, M, Honkanen, H, Knip, M, Hyöty, H, Vesikari, T et al.. Development and maturation of norovirus antibodies in childhood. Microbes Infect. 2016;18 (4):263-9. doi: 10.1016/j.micinf.2015.12.004. PubMed PMID:26724451 .
  2. Mäkinen, M, Mykkänen, J, Koskinen, M, Simell, V, Veijola, R, Hyöty, H et al.. Serum 25-Hydroxyvitamin D Concentrations in Children Progressing to Autoimmunity and Clinical Type 1 Diabetes. J Clin Endocrinol Metab. 2016;101 (2):723-9. doi: 10.1210/jc.2015-3504. PubMed PMID:26695863 PubMed Central PMC4880127.
  3. Lernmark, B, Lynch, K, Baxter, J, Roth, R, Simell, T, Smith, L et al.. Participant Experiences in the Environmental Determinants of Diabetes in the Young Study: Common Reasons for Withdrawing. J Diabetes Res. 2016;2016 :2720650. doi: 10.1155/2016/2720650. PubMed PMID:26682228 PubMed Central PMC4670659.
  4. Juusola, M, Parkkola, A, Härkönen, T, Siljander, H, Ilonen, J, Åkerblom, HK et al.. Positivity for Zinc Transporter 8 Autoantibodies at Diagnosis Is Subsequently Associated With Reduced β-Cell Function and Higher Exogenous Insulin Requirement in Children and Adolescents With Type 1 Diabetes. Diabetes Care. 2016;39 (1):118-21. doi: 10.2337/dc15-1027. PubMed PMID:26519333 PubMed Central PMC4876730.
  5. Andrén Aronsson, C, Lee, HS, Koletzko, S, Uusitalo, U, Yang, J, Virtanen, SM et al.. Effects of Gluten Intake on Risk of Celiac Disease: A Case-Control Study on a Swedish Birth Cohort. Clin Gastroenterol Hepatol. 2016;14 (3):403-409.e3. doi: 10.1016/j.cgh.2015.09.030. PubMed PMID:26453955 PubMed Central PMC4897964.
  6. Kantola, K, Hedman, L, Tanner, L, Simell, V, Mäkinen, M, Partanen, J et al.. B-Cell Responses to Human Bocaviruses 1-4: New Insights from a Childhood Follow-Up Study. PLoS One. 2015;10 (9):e0139096. doi: 10.1371/journal.pone.0139096. PubMed PMID:26418064 PubMed Central PMC4587975.
  7. Kondrashova, A, Nurminen, N, Patrikainen, M, Huhtala, H, Lehtonen, J, Toppari, J et al.. Influenza A virus antibodies show no association with pancreatic islet autoantibodies in children genetically predisposed to type 1 diabetes. Diabetologia. 2015;58 (11):2592-5. doi: 10.1007/s00125-015-3723-4. PubMed PMID:26253765 .
  8. Laiho, JE, Oikarinen, S, Oikarinen, M, Larsson, PG, Stone, VM, Hober, D et al.. Application of bioinformatics in probe design enables detection of enteroviruses on different taxonomic levels by advanced in situ hybridization technology. J Clin Virol. 2015;69 :165-71. doi: 10.1016/j.jcv.2015.06.085. PubMed PMID:26209400 .
  9. Blazevic, V, Malm, M, Salminen, M, Oikarinen, S, Hyöty, H, Veijola, R et al.. Multiple consecutive norovirus infections in the first 2 years of life. Eur J Pediatr. 2015;174 (12):1679-83. doi: 10.1007/s00431-015-2591-8. PubMed PMID:26152345 PubMed Central PMC4662724.
  10. Almasi, S, Aliparasti, MR, Aliasgarzadeh, A, Abd-Nikfarjam, B, Hyöty, H, Knip, M et al.. Investigation of CTLA-4-318C/T gene polymorphism in cases with type 1 diabetes of Azerbaijan, Northwest Iran. Immunol Lett. 2015;166 (2):134-9. doi: 10.1016/j.imlet.2015.05.021. PubMed PMID:26051683 .
  11. Peet, A, Hämäläinen, AM, Kool, P, Ilonen, J, Knip, M, Tillmann, V et al.. Circulating IGF1 and IGFBP3 in relation to the development of β-cell autoimmunity in young children. Eur J Endocrinol. 2015;173 (2):129-37. doi: 10.1530/EJE-14-1078. PubMed PMID:25947142 .
  12. Nurminen, N, Juuti, R, Oikarinen, S, Fan, YM, Lehto, KM, Mangani, C et al.. High-throughput multiplex quantitative polymerase chain reaction method for Giardia lamblia and Cryptosporidium species detection in stool samples. Am J Trop Med Hyg. 2015;92 (6):1222-6. doi: 10.4269/ajtmh.15-0054. PubMed PMID:25918202 PubMed Central PMC4458829.
  13. Lönnrot, M, Lynch, K, Larsson, HE, Lernmark, Å, Rewers, M, Hagopian, W et al.. A method for reporting and classifying acute infectious diseases in a prospective study of young children: TEDDY. BMC Pediatr. 2015;15 :24. doi: 10.1186/s12887-015-0333-8. PubMed PMID:25884839 PubMed Central PMC4377063.
  14. Acevedo, N, Reinius, LE, Vitezic, M, Fortino, V, Söderhäll, C, Honkanen, H et al.. Age-associated DNA methylation changes in immune genes, histone modifiers and chromatin remodeling factors within 5 years after birth in human blood leukocytes. Clin Epigenetics. 2015;7 :34. doi: 10.1186/s13148-015-0064-6. PubMed PMID:25874017 PubMed Central PMC4396570.
  15. Agardh, D, Lee, HS, Kurppa, K, Simell, V, Aronsson, CA, Jörneus, O et al.. Clinical features of celiac disease: a prospective birth cohort. Pediatrics. 2015;135 (4):627-34. doi: 10.1542/peds.2014-3675. PubMed PMID:25733751 PubMed Central PMC4379464.
  16. Kramná, L, Kolářová, K, Oikarinen, S, Pursiheimo, JP, Ilonen, J, Simell, O et al.. Gut virome sequencing in children with early islet autoimmunity. Diabetes Care. 2015;38 (5):930-3. doi: 10.2337/dc14-2490. PubMed PMID:25678103 .
  17. Steck, AK, Vehik, K, Bonifacio, E, Lernmark, A, Ziegler, AG, Hagopian, WA et al.. Predictors of Progression From the Appearance of Islet Autoantibodies to Early Childhood Diabetes: The Environmental Determinants of Diabetes in the Young (TEDDY). Diabetes Care. 2015;38 (5):808-13. doi: 10.2337/dc14-2426. PubMed PMID:25665818 PubMed Central PMC4407751.
  18. Kostic, AD, Gevers, D, Siljander, H, Vatanen, T, Hyötyläinen, T, Hämäläinen, AM et al.. The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes. Cell Host Microbe. 2015;17 (2):260-73. doi: 10.1016/j.chom.2015.01.001. PubMed PMID:25662751 PubMed Central PMC4689191.
  19. Moulder, R, Bhosale, SD, Erkkilä, T, Laajala, E, Salmi, J, Nguyen, EV et al.. Serum proteomes distinguish children developing type 1 diabetes in a cohort with HLA-conferred susceptibility. Diabetes. 2015;64 (6):2265-78. doi: 10.2337/db14-0983. PubMed PMID:25616278 .
  20. Aronsson, CA, Lee, HS, Liu, E, Uusitalo, U, Hummel, S, Yang, J et al.. Age at gluten introduction and risk of celiac disease. Pediatrics. 2015;135 (2):239-45. doi: 10.1542/peds.2014-1787. PubMed PMID:25601977 PubMed Central PMC4306795.
  21. Kemppainen, KM, Ardissone, AN, Davis-Richardson, AG, Fagen, JR, Gano, KA, León-Novelo, LG et al.. Early childhood gut microbiomes show strong geographic differences among subjects at high risk for type 1 diabetes. Diabetes Care. 2015;38 (2):329-32. doi: 10.2337/dc14-0850. PubMed PMID:25519450 PubMed Central PMC4302256.
  22. Reinert-Hartwall, L, Honkanen, J, Salo, HM, Nieminen, JK, Luopajärvi, K, Härkönen, T et al.. Th1/Th17 plasticity is a marker of advanced β cell autoimmunity and impaired glucose tolerance in humans. J Immunol. 2015;194 (1):68-75. doi: 10.4049/jimmunol.1401653. PubMed PMID:25480564 PubMed Central PMC4273995.
  23. Sillanpää, S, Oikarinen, S, Sipilä, M, Seppälä, E, Nurminen, N, Rautiainen, M et al.. Human parechovirus as a minor cause of acute otitis media in children. J Clin Virol. 2015;62 :106-9. doi: 10.1016/j.jcv.2014.11.002. PubMed PMID:25464964 .
  24. Krogvold, L, Edwin, B, Buanes, T, Frisk, G, Skog, O, Anagandula, M et al.. Detection of a low-grade enteroviral infection in the islets of langerhans of living patients newly diagnosed with type 1 diabetes. Diabetes. 2015;64 (5):1682-7. doi: 10.2337/db14-1370. PubMed PMID:25422108 .
  25. Törn, C, Hadley, D, Lee, HS, Hagopian, W, Lernmark, Å, Simell, O et al.. Role of Type 1 Diabetes-Associated SNPs on Risk of Autoantibody Positivity in the TEDDY Study. Diabetes. 2015;64 (5):1818-29. doi: 10.2337/db14-1497. PubMed PMID:25422107 PubMed Central PMC4407865.
  26. Larsson, PG, Lakshmikanth, T, Laitinen, OH, Utorova, R, Jacobson, S, Oikarinen, M et al.. A preclinical study on the efficacy and safety of a new vaccine against Coxsackievirus B1 reveals no risk for accelerated diabetes development in mouse models. Diabetologia. 2015;58 (2):346-54. doi: 10.1007/s00125-014-3436-0. PubMed PMID:25370797 .
  27. Roth, R, Lynch, K, Lernmark, B, Baxter, J, Simell, T, Smith, L et al.. Maternal anxiety about a child’s diabetes risk in the TEDDY study: the potential role of life stress, postpartum depression, and risk perception. Pediatr Diabetes. 2015;16 (4):287-98. doi: 10.1111/pedi.12168. PubMed PMID:25082392 PubMed Central PMC4312746.

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