Modern societies use tens of thousands of chemicals, yet the toxicological profiles of most remain poorly understood. In Europe alone, an estimated 75% of marketed chemicals lack sufficient toxicity data. We perform in-depth toxicity and mode-of-action screening of various chemicals and environmental exposures, including pharmaceuticals, PFAS, pesticides, and other ubiquitous pollutants. The results are expected to go beyond traditional single-endpoint toxicity assays by incorporating multidimensional 3D models. By combining functional assays with large-scale multi-omics profiling, lipidomics, proteomics, and metabolomics, we aim to identify specific molecular signatures of chemical exposure. These signatures reveal potential biomarkers for early detection of exposure and effect. Our approach is expected to improve predictions of drug efficacy, chemical toxicity and disease mechanisms.
Due to climate change, population growth and antimicrobial resistance environmental data archival efforts and human disease trend detection are now more critical than ever. Wastewater is a source of various markers that reflect comprehensive unbiased health information of the entire community. Wastewater-Based Surveillance (WBS) is suitable for monitoring various biomarkers and chemicals, such as pharmaceuticals (including antimicrobials). Our research group is experienced in the surveillance of various health markers in municipal wastewater, as well as hospital wastewater.
References
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