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Environmental Health

Publications

2024

  1. Lipponen, A, Kolehmainen, A, Oikarinen, S, Hokajärvi, AM, Lehto, KM, Heikinheimo, A et al.. Detection of SARS-COV-2 variants and their proportions in wastewater samples using next-generation sequencing in Finland. Sci Rep. 2024;14 (1):7751. doi: 10.1038/s41598-024-58113-8. PubMed PMID:38565591 PubMed Central PMC10987589.
  2. Tiwari, A, Lehto, KM, Paspaliari, DK, Al-Mustapha, AI, Sarekoski, A, Hokajärvi, AM et al.. Developing wastewater-based surveillance schemes for multiple pathogens: The WastPan project in Finland. Sci Total Environ. 2024;926 :171401. doi: 10.1016/j.scitotenv.2024.171401. PubMed PMID:38467259 .
  3. Hakola, L, Mramba, LK, Uusitalo, U, Andrén Aronsson, C, Hummel, S, Niinistö, S et al.. Intake of B vitamins and the risk of developing islet autoimmunity and type 1 diabetes in the TEDDY study. Eur J Nutr. 2024; :. doi: 10.1007/s00394-024-03346-6. PubMed PMID:38413484 .
  4. Hyöty, H, Kääriäinen, S, Laiho, JE, Comer, GM, Tian, W, Härkönen, T et al.. Safety, tolerability and immunogenicity of PRV-101, a multivalent vaccine targeting coxsackie B viruses (CVBs) associated with type 1 diabetes: a double-blind randomised placebo-controlled Phase I trial. Diabetologia. 2024;67 (5):811-821. doi: 10.1007/s00125-024-06092-w. PubMed PMID:38369573 PubMed Central PMC10954874.
  5. Heljanko, V, Tyni, O, Johansson, V, Virtanen, JP, Räisänen, K, Lehto, KM et al.. Clinically relevant sequence types of carbapenemase-producing Escherichia coli and Klebsiella pneumoniae detected in Finnish wastewater in 2021-2022. Antimicrob Resist Infect Control. 2024;13 (1):14. doi: 10.1186/s13756-024-01370-z. PubMed PMID:38291521 PubMed Central PMC10829384.

Search PubMed

2023

  1. Lin, J, Moradi, E, Salenius, K, Lehtipuro, S, Häkkinen, T, Laiho, JE et al.. Distinct transcriptomic profiles in children prior to the appearance of type 1 diabetes-linked islet autoantibodies and following enterovirus infection. Nat Commun. 2023;14 (1):7630. doi: 10.1038/s41467-023-42763-9. PubMed PMID:37993433 PubMed Central PMC10665402.
  2. Lönnrot, M, Lynch, KF, Rewers, M, Lernmark, Å, Vehik, K, Akolkar, B et al.. Gastrointestinal Infections Modulate the Risk for Insulin Autoantibodies as the First-Appearing Autoantibody in the TEDDY Study. Diabetes Care. 2023;46 (11):1908-1915. doi: 10.2337/dc23-0518. PubMed PMID:37607456 PubMed Central PMC10620548.
  3. Uusitalo, U, Mramba, LK, Aronsson, CA, Vehik, K, Yang, J, Hummel, S et al.. HLA Genotype and Probiotics Modify the Association Between Timing of Solid Food Introduction and Islet Autoimmunity in the TEDDY Study. Diabetes Care. 2023;46 (10):1839-1847. doi: 10.2337/dc23-0417. PubMed PMID:37579501 PubMed Central PMC10516243.
  4. Krischer, JP, Lernmark, Å, Hagopian, WA, Rewers, MJ, McIndoe, R, Toppari, J et al.. SARS-CoV-2 – No Increased Islet Autoimmunity or Type 1 Diabetes in Teens. N Engl J Med. 2023;389 (5):474-475. doi: 10.1056/NEJMc2216477. PubMed PMID:37530831 PubMed Central PMC10481371.
  5. Heljanko, V, Johansson, V, Räisänen, K, Anttila, VJ, Lyytikäinen, O, Jalava, J et al.. Genomic epidemiology of nosocomial carbapenemase-producing in sewerage systems in the Helsinki metropolitan area, Finland. Front Microbiol. 2023;14 :1165751. doi: 10.3389/fmicb.2023.1165751. PubMed PMID:37303777 PubMed Central PMC10250652.
  6. Jouppila, NVV, Lehtonen, J, Seppälä, E, Puustinen, L, Oikarinen, S, Laitinen, OH et al.. Assessment of Enterovirus Antibodies during Early Childhood Using a Multiplex Immunoassay. Microbiol Spectr. 2023;11 (3):e0535222. doi: 10.1128/spectrum.05352-22. PubMed PMID:37227147 PubMed Central PMC10269870.
  7. Liu, X, Johnson, SB, Lynch, KF, Cordan, K, Pate, R, Butterworth, MD et al.. Physical Activity and the Development of Islet Autoimmunity and Type 1 Diabetes in 5- to 15-Year-Old Children Followed in the TEDDY Study. Diabetes Care. 2023;46 (7):1409-1416. doi: 10.2337/dc23-0036. PubMed PMID:37141102 PubMed Central PMC10300517.
  8. Roslund, MI, Parajuli, A, Hui, N, Puhakka, R, Grönroos, M, Soininen, L et al.. Skin, gut, and sand metagenomic data on placebo-controlled sandbox biodiversity intervention study. Data Brief. 2023;47 :109003. doi: 10.1016/j.dib.2023.109003. PubMed PMID:36915639 PubMed Central PMC10006422.
  9. Thorsen, SU, Liu, X, Kataria, Y, Mandrup-Poulsen, T, Kaur, S, Uusitalo, U et al.. Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study. Diabetes Care. 2023;46 (5):1014-1018. doi: 10.2337/dc22-1359. PubMed PMID:36867433 PubMed Central PMC10154662.
  10. Tiwari, A, Adhikari, S, Kaya, D, Islam, MA, Malla, B, Sherchan, SP et al.. Monkeypox outbreak: Wastewater and environmental surveillance perspective. Sci Total Environ. 2023;856 (Pt 2):159166. doi: 10.1016/j.scitotenv.2022.159166. PubMed PMID:36202364 PubMed Central PMC9534267.
  11. Luoma, J, Adubra, L, Ashorn, P, Ashorn, U, Bendabenda, J, Dewey, KG et al.. Association between asymptomatic infections and linear growth in 18-24-month-old Malawian children. Matern Child Nutr. 2023;19 (1):e13417. doi: 10.1111/mcn.13417. PubMed PMID:36111423 PubMed Central PMC9749610.

Search PubMed

2022
  1. Tiwari, A, Kurittu, P, Al-Mustapha, AI, Heljanko, V, Johansson, V, Thakali, O et al.. Wastewater surveillance of antibiotic-resistant bacterial pathogens: A systematic review. Front Microbiol. 2022;13 :977106. doi: 10.3389/fmicb.2022.977106. PubMed PMID:36590429 PubMed Central PMC9798455.
  2. Vatanen, T, Jabbar, KS, Ruohtula, T, Honkanen, J, Avila-Pacheco, J, Siljander, H et al.. Mobile genetic elements from the maternal microbiome shape infant gut microbial assembly and metabolism. Cell. 2022;185 (26):4921-4936.e15. doi: 10.1016/j.cell.2022.11.023. PubMed PMID:36563663 PubMed Central PMC9869402.
  3. Tiwari, A, Adhikari, S, Kaya, D, Islam, MA, Malla, B, Sherchan, SP et al.. Monkeypox outbreak: Wastewater and environmental surveillance perspective. Sci Total Environ. 2023;856 (Pt 2):159166. doi: 10.1016/j.scitotenv.2022.159166. PubMed PMID:36202364 PubMed Central PMC9534267.
  4. Vehik, K, Boulware, D, Killian, M, Rewers, M, McIndoe, R, Toppari, J et al.. Rising Hemoglobin A1c in the Nondiabetic Range Predicts Progression of Type 1 Diabetes As Well As Oral Glucose Tolerance Tests. Diabetes Care. 2022;45 (10):2342-2349. doi: 10.2337/dc22-0828. PubMed PMID:36150054 PubMed Central PMC9587339.
  5. Krischer, JP, Liu, X, Lernmark, Å, Hagopian, WA, Rewers, MJ, She, JX et al.. Predictors of the Initiation of Islet Autoimmunity and Progression to Multiple Autoantibodies and Clinical Diabetes: The TEDDY Study. Diabetes Care. 2022;45 (10):2271-2281. doi: 10.2337/dc21-2612. PubMed PMID:36150053 PubMed Central PMC9643148.
  6. Luoma, J, Adubra, L, Ashorn, P, Ashorn, U, Bendabenda, J, Dewey, KG et al.. Association between asymptomatic infections and linear growth in 18-24-month-old Malawian children. Matern Child Nutr. 2023;19 (1):e13417. doi: 10.1111/mcn.13417. PubMed PMID:36111423 PubMed Central PMC9749610.
  7. Roslund, MI, Parajuli, A, Hui, N, Puhakka, R, Grönroos, M, Soininen, L et al.. A Placebo-controlled double-blinded test of the biodiversity hypothesis of immune-mediated diseases: Environmental microbial diversity elicits changes in cytokines and increase in T regulatory cells in young children. Ecotoxicol Environ Saf. 2022;242 :113900. doi: 10.1016/j.ecoenv.2022.113900. PubMed PMID:35930838 .
  8. Sioofy-Khojine, AB, Richardson, SJ, Locke, JM, Oikarinen, S, Nurminen, N, Laine, AP et al.. Detection of enterovirus RNA in peripheral blood mononuclear cells correlates with the presence of the predisposing allele of the type 1 diabetes risk gene IFIH1 and with disease stage. Diabetologia. 2022;65 (10):1701-1709. doi: 10.1007/s00125-022-05753-y. PubMed PMID:35867130 PubMed Central PMC9477938.
  9. Tiwari, A, Ahmed, W, Oikarinen, S, Sherchan, SP, Heikinheimo, A, Jiang, G et al.. Application of digital PCR for public health-related water quality monitoring. Sci Total Environ. 2022;837 :155663. doi: 10.1016/j.scitotenv.2022.155663. PubMed PMID:35523326 .
  10. Välikangas, T, Lietzén, N, Jaakkola, MK, Krogvold, L, Eike, MC, Kallionpää, H et al.. Pancreas Whole Tissue Transcriptomics Highlights the Role of the Exocrine Pancreas in Patients With Recently Diagnosed Type 1 Diabetes. Front Endocrinol (Lausanne). 2022;13 :861985. doi: 10.3389/fendo.2022.861985. PubMed PMID:35498413 PubMed Central PMC9044038.
  11. Soininen, L, Roslund, MI, Nurminen, N, Puhakka, R, Laitinen, OH, Hyöty, H et al.. Indoor green wall affects health-associated commensal skin microbiota and enhances immune regulation: a randomized trial among urban office workers. Sci Rep. 2022;12 (1):6518. doi: 10.1038/s41598-022-10432-4. PubMed PMID:35444249 PubMed Central PMC9021224.
  12. Hård Af Segerstad, EM, Liu, X, Uusitalo, U, Agardh, D, Andrén Aronsson, C, TEDDY Study Group et al.. Sources of dietary gluten in the first 2 years of life and associations with celiac disease autoimmunity and celiac disease in Swedish genetically predisposed children: The Environmental Determinants of Diabetes in the Young (TEDDY) study. Am J Clin Nutr. 2022;116 (2):394-403. doi: 10.1093/ajcn/nqac086. PubMed PMID:35394004 PubMed Central PMC9348971.
  13. Törn, C, Liu, X, Onengut-Gumuscu, S, Counts, KM, Moreno, JL, Remedios, CL et al.. Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study. Sci Rep. 2022;12 (1):4516. doi: 10.1038/s41598-022-08058-7. PubMed PMID:35296692 PubMed Central PMC8927592.
  14. Ferrat, LA, Vehik, K, Sharp, SA, Lernmark, Å, Rewers, MJ, She, JX et al.. Author Correction: A combined risk score enhances prediction of type 1 diabetes among susceptible children. Nat Med. 2022;28 (3):599. doi: 10.1038/s41591-021-01631-z. PubMed PMID:35165454 .
  15. Kortekangas, E, Fan, YM, Chaima, D, Lehto, KM, Malamba-Banda, C, Matchado, A et al.. Associations between Gut Microbiota and Intestinal Inflammation, Permeability and Damage in Young Malawian Children. J Trop Pediatr. 2022;68 (2):. doi: 10.1093/tropej/fmac012. PubMed PMID:35149871 PubMed Central PMC8846364.
  16. Jacobsen, LM, Vehik, K, Veijola, R, Warncke, K, Toppari, J, Steck, AK et al.. Heterogeneity of DKA Incidence and Age-Specific Clinical Characteristics in Children Diagnosed With Type 1 Diabetes in the TEDDY Study. Diabetes Care. 2022;45 (3):624-633. doi: 10.2337/dc21-0422. PubMed PMID:35043162 PubMed Central PMC8918232.
  17. Melin, J, Lynch, KF, Lundgren, M, Aronsson, CA, Larsson, HE, Johnson, SB et al.. Is staff consistency important to parents’ satisfaction in a longitudinal study of children at risk for type 1 diabetes: the TEDDY study. BMC Endocr Disord. 2022;22 (1):19. doi: 10.1186/s12902-021-00929-w. PubMed PMID:35012530 PubMed Central PMC8744326.
  18. González-Rodríguez, MI, Nurminen, N, Kummola, L, Laitinen, OH, Oikarinen, S, Parajuli, A et al.. Effect of inactivated nature-derived microbial composition on mouse immune system. Immun Inflamm Dis. 2022;10 (3):e579. doi: 10.1002/iid3.579. PubMed PMID:34873877 PubMed Central PMC8926502.

Search PubMed

2021
  1. González-Rodríguez, MI, Nurminen, N, Kummola, L, Laitinen, OH, Oikarinen, S, Parajuli, A et al.. Effect of inactivated nature-derived microbial composition on mouse immune system. Immun Inflamm Dis. 2022;10 (3):e579. doi: 10.1002/iid3.579. PubMed PMID:34873877 PubMed Central PMC8926502.
  2. Brænne, I, Onengut-Gumuscu, S, Chen, R, Manichaikul, AW, Rich, SS, Chen, WM et al.. Dynamic changes in immune gene co-expression networks predict development of type 1 diabetes. Sci Rep. 2021;11 (1):22651. doi: 10.1038/s41598-021-01840-z. PubMed PMID:34811390 PubMed Central PMC8609030.
  3. Roslund, MI, Puhakka, R, Nurminen, N, Oikarinen, S, Siter, N, Grönroos, M et al.. Long-term biodiversity intervention shapes health-associated commensal microbiota among urban day-care children. Environ Int. 2021;157 :106811. doi: 10.1016/j.envint.2021.106811. PubMed PMID:34403882 .
  4. Oikarinen, S, Krogvold, L, Edwin, B, Buanes, T, Korsgren, O, Laiho, JE et al.. Characterisation of enterovirus RNA detected in the pancreas and other specimens of live patients with newly diagnosed type 1 diabetes in the DiViD study. Diabetologia. 2021;64 (11):2491-2501. doi: 10.1007/s00125-021-05525-0. PubMed PMID:34390364 PubMed Central PMC8494699.
  5. Cinek, O, Polackova, K, Odeh, R, Alassaf, A, Kramná, L, Ibekwe, MU et al.. Blastocystis in the faeces of children from six distant countries: prevalence, quantity, subtypes and the relation to the gut bacteriome. Parasit Vectors. 2021;14 (1):399. doi: 10.1186/s13071-021-04859-3. PubMed PMID:34384477 PubMed Central PMC8359624.
  6. Mohanraj, U, Jokinen, M, Thapa, RR, Paloniemi, M, Vesikari, T, Lappalainen, M et al.. Human Protoparvovirus DNA and IgG in Children and Adults with and without Respiratory or Gastrointestinal Infections. Viruses. 2021;13 (3):. doi: 10.3390/v13030483. PubMed PMID:33804173 PubMed Central PMC7999311.
  7. Ruohtula, T, Kondrashova, A, Lehtonen, J, Oikarinen, S, Hämäläinen, AM, Niemelä, O et al.. Immunomodulatory Effects of Rhinovirus and Enterovirus Infections During the First Year of Life. Front Immunol. 2020;11 :567046. doi: 10.3389/fimmu.2020.567046. PubMed PMID:33643278 PubMed Central PMC7905218.
  8. Bonifacio, E, Weiß, A, Winkler, C, Hippich, M, Rewers, MJ, Toppari, J et al.. An Age-Related Exponential Decline in the Risk of Multiple Islet Autoantibody Seroconversion During Childhood. Diabetes Care. 2021; :. doi: 10.2337/dc20-2122. PubMed PMID:33627366 PubMed Central PMC8929192.
  9. Hokajärvi, AM, Rytkönen, A, Tiwari, A, Kauppinen, A, Oikarinen, S, Lehto, KM et al.. The detection and stability of the SARS-CoV-2 RNA biomarkers in wastewater influent in Helsinki, Finland. Sci Total Environ. 2021;770 :145274. doi: 10.1016/j.scitotenv.2021.145274. PubMed PMID:33513496 PubMed Central PMC7825999.
  10. Maleta, K, Fan, YM, Luoma, J, Ashorn, U, Bendabenda, J, Dewey, KG et al.. Infections and systemic inflammation are associated with lower plasma concentration of insulin-like growth factor I among Malawian children. Am J Clin Nutr. 2021;113 (2):380-390. doi: 10.1093/ajcn/nqaa327. PubMed PMID:33381802 PubMed Central PMC7851819.
  11. Vari, HK, Roslund, MI, Oikarinen, S, Nurminen, N, Puhakka, R, Parajuli, A et al.. Associations between land cover categories, gaseous PAH levels in ambient air and endocrine signaling predicted from gut bacterial metagenome of the elderly. Chemosphere. 2021;265 :128965. doi: 10.1016/j.chemosphere.2020.128965. PubMed PMID:33248729 .
  12. Liu, Z, Fan, YM, Ashorn, P, Cheung, YB, Hallamaa, L, Hyöty, H et al.. Faecal regenerating 1B protein concentration is not associated with child growth in rural Malawi. J Paediatr Child Health. 2021;57 (3):388-394. doi: 10.1111/jpc.15231. PubMed PMID:33112481 PubMed Central PMC8048694.

Search PubMed

2020
  1. Ruohtula, T, Kondrashova, A, Lehtonen, J, Oikarinen, S, Hämäläinen, AM, Niemelä, O et al.. Immunomodulatory Effects of Rhinovirus and Enterovirus Infections During the First Year of Life. Front Immunol. 2020;11 :567046. doi: 10.3389/fimmu.2020.567046. PubMed PMID:33643278 PubMed Central PMC7905218.
  2. Salmikangas, S, Laiho, JE, Kalander, K, Laajala, M, Honkimaa, A, Shanina, I et al.. Detection of Viral -RNA and +RNA Strands in Enterovirus-Infected Cells and Tissues. Microorganisms. 2020;8 (12):. doi: 10.3390/microorganisms8121928. PubMed PMID:33291747 PubMed Central PMC7761939.
  3. Vari, HK, Roslund, MI, Oikarinen, S, Nurminen, N, Puhakka, R, Parajuli, A et al.. Associations between land cover categories, gaseous PAH levels in ambient air and endocrine signaling predicted from gut bacterial metagenome of the elderly. Chemosphere. 2021;265 :128965. doi: 10.1016/j.chemosphere.2020.128965. PubMed PMID:33248729 .
  4. Honkimaa, A, Kimura, B, Sioofy-Khojine, AB, Lin, J, Laiho, J, Oikarinen, S et al.. Genetic Adaptation of Coxsackievirus B1 during Persistent Infection in Pancreatic Cells. Microorganisms. 2020;8 (11):. doi: 10.3390/microorganisms8111790. PubMed PMID:33203081 PubMed Central PMC7697981.
  5. Liu, Z, Fan, YM, Ashorn, P, Cheung, YB, Hallamaa, L, Hyöty, H et al.. Faecal regenerating 1B protein concentration is not associated with child growth in rural Malawi. J Paediatr Child Health. 2021;57 (3):388-394. doi: 10.1111/jpc.15231. PubMed PMID:33112481 PubMed Central PMC8048694.
  6. Roslund, MI, Puhakka, R, Grönroos, M, Nurminen, N, Oikarinen, S, Gazali, AM et al.. Biodiversity intervention enhances immune regulation and health-associated commensal microbiota among daycare children. Sci Adv. 2020;6 (42):. doi: 10.1126/sciadv.aba2578. PubMed PMID:33055153 PubMed Central PMC7556828.
  7. Ferrat, LA, Vehik, K, Sharp, SA, Lernmark, Å, Rewers, MJ, She, JX et al.. A combined risk score enhances prediction of type 1 diabetes among susceptible children. Nat Med. 2020;26 (8):1247-1255. doi: 10.1038/s41591-020-0930-4. PubMed PMID:32770166 PubMed Central PMC7556983.
  8. Oikarinen, M, Bertolet, L, Toniolo, A, Oikarinen, S, Laiho, JE, Pugliese, A et al.. Differential Detection of Encapsidated versus Unencapsidated Enterovirus RNA in Samples Containing Pancreatic Enzymes-Relevance for Diabetes Studies. Viruses. 2020;12 (7):. doi: 10.3390/v12070747. PubMed PMID:32664501 PubMed Central PMC7411921.
  9. Vehik, K, Bonifacio, E, Lernmark, Å, Yu, L, Williams, A, Schatz, D et al.. Hierarchical Order of Distinct Autoantibody Spreading and Progression to Type 1 Diabetes in the TEDDY Study. Diabetes Care. 2020;43 (9):2066-2073. doi: 10.2337/dc19-2547. PubMed PMID:32641373 PubMed Central PMC7440899.
  10. Honkimaa, A, Sioofy-Khojine, AB, Oikarinen, S, Bertin, A, Hober, D, Hyöty, H et al.. Eradication of persistent coxsackievirus B infection from a pancreatic cell line with clinically used antiviral drugs. J Clin Virol. 2020;128 :104334. doi: 10.1016/j.jcv.2020.104334. PubMed PMID:32450550 .
  11. Sane, F, Bertin, A, Sioofy-Khojine, AB, Oikarinen, S, Alidjinou, EK, Veijola, R et al.. Enhancing and neutralizing anti-coxsackievirus activities in serum samples from patients prior to development of type 1 diabetes. Diabetes Metab Res Rev. 2020;36 (6):e3305. doi: 10.1002/dmrr.3305. PubMed PMID:32118346 .
  12. Seppälä, EM, Oikarinen, S, Lehtonen, JP, Neupane, S, Honkanen, H, Tyni, I et al.. Association of Picornavirus Infections With Acute Otitis Media in a Prospective Birth Cohort Study. J Infect Dis. 2020;222 (2):324-332. doi: 10.1093/infdis/jiaa087. PubMed PMID:32108877 .
  13. Li, Q, Parikh, H, Butterworth, MD, Lernmark, Å, Hagopian, W, Rewers, M et al.. Longitudinal Metabolome-Wide Signals Prior to the Appearance of a First Islet Autoantibody in Children Participating in the TEDDY Study. Diabetes. 2020;69 (3):465-476. doi: 10.2337/db19-0756. PubMed PMID:32029481 PubMed Central PMC7034190.
  14. Parajuli, A, Hui, N, Puhakka, R, Oikarinen, S, Grönroos, M, Selonen, VAO et al.. Yard vegetation is associated with gut microbiota composition. Sci Total Environ. 2020;713 :136707. doi: 10.1016/j.scitotenv.2020.136707. PubMed PMID:32019041 .
  15. Liu, X, Vehik, K, Huang, Y, Elding Larsson, H, Toppari, J, Ziegler, AG et al.. Distinct Growth Phases in Early Life Associated With the Risk of Type 1 Diabetes: The TEDDY Study. Diabetes Care. 2020;43 (3):556-562. doi: 10.2337/dc19-1670. PubMed PMID:31896601 PubMed Central PMC7035588.
  16. Hayes, A, Nguyen, D, Andersson, M, Antón, A, Bailly, JL, Beard, S et al.. A European multicentre evaluation of detection and typing methods for human enteroviruses and parechoviruses using RNA transcripts. J Med Virol. 2020;92 (8):1065-1074. doi: 10.1002/jmv.25659. PubMed PMID:31883139 PubMed Central PMC7496258.
  17. Lindfors, K, Lin, J, Lee, HS, Hyöty, H, Nykter, M, Kurppa, K et al.. Metagenomics of the faecal virome indicate a cumulative effect of enterovirus and gluten amount on the risk of coeliac disease autoimmunity in genetically at risk children: the TEDDY study. Gut. 2020;69 (8):1416-1422. doi: 10.1136/gutjnl-2019-319809. PubMed PMID:31744911 PubMed Central PMC7234892.

Search PubMed

 

2019

Hui N, Parajuli A, Puhakka R, Grönroos M, Roslund MI, Vari HK, Selonen VAO, Yan G, Siter N, Nurminen N, Oikarinen S, Laitinen OH, Rajaniemi J, Hyöty H, Sinkkonen A
Temporal variation in indoor transfer of dirt-associated environmental bacteria in agricultural and urban areas.
Environ Int ;2019
PMID

Lehto KM, Fan YM, Oikarinen S, Nurminen N, Hallamaa L, Juuti R, Mangani C, Maleta K, Hyöty H, Ashorn P
Presence of Giardia lamblia in stools of six- to 18-month old asymptomatic Malawians is associated with children’s growth failure.
Acta Paediatr ;108(10)1833-1840, 2019
PMID

Lietzén N, Hirvonen K, Honkimaa A, Buchacher T, Laiho JE, Oikarinen S, Mazur MA, Flodström-Tullberg M, Dufour E, Sioofy-Khojine AB, Hyöty H, Lahesmaa R
Coxsackievirus B Persistence Modifies the Proteome and the Secretome of Pancreatic Ductal Cells.
iScience ;2019
PMID

Fan YM, Oikarinen S, Lehto KM, Nurminen N, Juuti R, Mangani C, Maleta K, Hyöty H, Ashorn P
High prevalence of selected viruses and parasites and their predictors in Malawian children.
Epidemiol Infect ;2019
PMID

2018

Nurminen N, Lin J, Grönroos M, Puhakka R, Kramna L, Vari HK, Viskari H, Oikarinen S, Roslund M, Parajuli A, Tyni I, Cinek O, Laitinen O, Hyöty H, Sinkkonen A
Nature-derived microbiota exposure as a novel immunomodulatory approach.
Future Microbiol ;2018
PMID

Yassour M, Jason E, Hogstrom LJ, Arthur TD, Tripathi S, Siljander H, Selvenius J, Oikarinen S, Hyöty H, Virtanen SM, Ilonen J, Ferretti P, Pasolli E, Tett A, Asnicar F, Segata N, Vlamakis H, Lander ES, Huttenhower C, Knip M, Xavier RJ
Strain-Level Analysis of Mother-to-Child Bacterial Transmission during the First Few Months of Life.
Cell Host Microbe ;24(1)146-154.e4, 2018
PMID

Sioofy-Khojine AB, Lehtonen J, Nurminen N, Laitinen OH, Oikarinen S, Huhtala H, Pakkanen O, Ruokoranta T, Hankaniemi MM, Toppari J, Vähä-Mäkilä M, Ilonen J, Veijola R, Knip M, Hyöty H
Coxsackievirus B1 infections are associated with the initiation of insulin-driven autoimmunity that progresses to type 1 diabetes.
Diabetologia ;61(5)1193-1202, 2018
PMID

Stone VM, Hankaniemi MM, Svedin E, Sioofy-Khojine A, Oikarinen S, Hyöty H, Laitinen OH, Hytönen VP, Flodström-Tullberg M
A Coxsackievirus B vaccine protects against virus-induced diabetes in an experimental mouse model of type 1 diabetes.
Diabetologia ;61(2)476-481, 2018
PMID

Lietzen N, An LTT, Jaakkola MK, Kallionpää H, Oikarinen S, Mykkänen J, Knip M, Veijola R, Ilonen J, Toppari J, Hyöty H, Lahesmaa R, Elo LL
Enterovirus-associated changes in blood transcriptomic profiles of children with genetic susceptibility to type 1 diabetes.
Diabetologia ;61(2)381-388, 2018
PMID

Viskari H, Oikarinen S, Hoppu S, Vuorinen T, Huhtala H, Toppari J, Veijola R, Ilonen J, Knip M, Hyöty H
Live attenuated enterovirus vaccine (OPV) is not associated with islet autoimmunity in children with genetic susceptibility to type 1 diabetes: prospective cohort study.
Diabetologia ;61(1)203-209, 2018
PMID

2017

Cinek O, Kramna L, Lin J, Oikarinen S, Kolarova K, Ilonen J, Simell O, Veijola R, Autio R, Hyöty H
Imbalance of bacteriome profiles within the Finnish Diabetes Prediction and Prevention study: Parallel use of 16S profiling and virome sequencing in stool samples from children with islet autoimmunity and matched controls.
Pediatr Diabetes ;18(7)588-598, 2017
PMID

Honkanen H, Oikarinen S, Nurminen N, Laitinen OH, Huhtala H, Lehtonen J, Ruokoranta T, Hankaniemi MM, Lecouturier V, Almond JW, Tauriainen S, Simell O, Ilonen J, Veijola R, Viskari H, Knip M, Hyöty H
Detection of enteroviruses in stools precedes islet autoimmunity by several months: possible evidence for slowly operating mechanisms in virus-induced autoimmunity.
Diabetologia ;60(3)424-431, 2017
PMID

2016

Seppälä E, Sillanpää S, Nurminen N, Huhtala H, Toppari J, Ilonen J, Veijola R, Knip M, Sipilä M, Laranne J, Oikarinen S, Hyöty H
Human enterovirus and rhinovirus infections are associated with otitis media in a prospective birth cohort study.
J Clin Virol ;2016
PMID

Sillanpää S, Oikarinen S, Sipilä M, Kramna L, Rautiainen M, Huhtala H, Aittoniemi J, Laranne J, Hyöty H, Cinek O
Moraxella catarrhalis Might Be More Common than Expected in Acute Otitis Media in Young Finnish Children.
J Clin Microbiol ;54(9)2373-9, 2016
PMID

2015

Blazevic V, Malm M, Salminen M, Oikarinen S, Hyöty H, Veijola R, Vesikari T
Multiple consecutive norovirus infections in the first 2 years of life.
Eur J Pediatr ;174(12)1679-83, 2015
PMID

Laiho JE, Oikarinen S, Oikarinen M, Larsson PG, Stone VM, Hober D, Oberste S, Flodström-Tullberg M, Isola J, Hyöty H
Application of bioinformatics in probe design enables detection of enteroviruses on different taxonomic levels by advanced in situ hybridization technology.
J Clin Virol ;2015
PMID

Nurminen N, Juuti R, Oikarinen S, Fan YM, Lehto KM, Mangani C, Maleta K, Ashorn P, Hyöty H
High-throughput multiplex quantitative polymerase chain reaction method for Giardia lamblia and Cryptosporidium species detection in stool samples.
Am J Trop Med Hyg ;92(6)1222-6, 2015
PMID

Kramná L, Kolářová K, Oikarinen S, Pursiheimo JP, Ilonen J, Simell O, Knip M, Veijola R, Hyöty H, Cinek O
Gut virome sequencing in children with early islet autoimmunity.
Diabetes Care ;38(5)930-3, 2015
PMID

Krogvold L, Edwin B, Buanes T, Frisk G, Skog O, Anagandula M, Korsgren O, Undlien D, Eike MC, Richardson SJ, Leete P, Morgan NG, Oikarinen S, Oikarinen M, Laiho JE, Hyöty H, Ludvigsson J, Hanssen KF, Dahl-Jørgensen K
Detection of a low-grade enteroviral infection in the islets of langerhans of living patients newly diagnosed with type 1 diabetes.
Diabetes ;64(5)1682-7, 2015
PMID

Sillanpää S, Oikarinen S, Sipilä M, Seppälä E, Nurminen N, Rautiainen M, Laranne J, Hyöty H
Human parechovirus as a minor cause of acute otitis media in children.
J Clin Virol ;2015
PMID