Publications

2021

  1. Mohanraj, U, Jokinen, M, Thapa, RR, Paloniemi, M, Vesikari, T, Lappalainen, M et al.. Human Protoparvovirus DNA and IgG in Children and Adults with and without Respiratory or Gastrointestinal Infections. Viruses. 2021;13 (3):. doi: 10.3390/v13030483. PubMed PMID:33804173 PubMed Central PMC7999311.
  2. Smith, LB, Lynch, KF, Driscoll, KA, Johnson, SB, TEDDY Study Group. Parental monitoring for type 1 diabetes in genetically at-risk young children: The TEDDY study. Pediatr Diabetes. 2021; :. doi: 10.1111/pedi.13173. PubMed PMID:33704891 .
  3. Ruohtula, T, Kondrashova, A, Lehtonen, J, Oikarinen, S, Hämäläinen, AM, Niemelä, O et al.. Immunomodulatory Effects of Rhinovirus and Enterovirus Infections During the First Year of Life. Front Immunol. 2020;11 :567046. doi: 10.3389/fimmu.2020.567046. PubMed PMID:33643278 PubMed Central PMC7905218.
  4. Bonifacio, E, Weiß, A, Winkler, C, Hippich, M, Rewers, MJ, Toppari, J et al.. An Age-Related Exponential Decline in the Risk of Multiple Islet Autoantibody Seroconversion During Childhood. Diabetes Care. 2021; :. doi: 10.2337/dc20-2122. PubMed PMID:33627366 .
  5. Hokajärvi, AM, Rytkönen, A, Tiwari, A, Kauppinen, A, Oikarinen, S, Lehto, KM et al.. The detection and stability of the SARS-CoV-2 RNA biomarkers in wastewater influent in Helsinki, Finland. Sci Total Environ. 2021;770 :145274. doi: 10.1016/j.scitotenv.2021.145274. PubMed PMID:33513496 PubMed Central PMC7825999.
  6. Maleta, K, Fan, YM, Luoma, J, Ashorn, U, Bendabenda, J, Dewey, KG et al.. Infections and systemic inflammation are associated with lower plasma concentration of insulin-like growth factor I among Malawian children. Am J Clin Nutr. 2021;113 (2):380-390. doi: 10.1093/ajcn/nqaa327. PubMed PMID:33381802 PubMed Central PMC7851819.
  7. Vari, HK, Roslund, MI, Oikarinen, S, Nurminen, N, Puhakka, R, Parajuli, A et al.. Associations between land cover categories, gaseous PAH levels in ambient air and endocrine signaling predicted from gut bacterial metagenome of the elderly. Chemosphere. 2021;265 :128965. doi: 10.1016/j.chemosphere.2020.128965. PubMed PMID:33248729 .
  8. Liu, Z, Fan, YM, Ashorn, P, Cheung, YB, Hallamaa, L, Hyöty, H et al.. Faecal regenerating 1B protein concentration is not associated with child growth in rural Malawi. J Paediatr Child Health. 2021;57 (3):388-394. doi: 10.1111/jpc.15231. PubMed PMID:33112481 .

Search PubMed

2020

  1. Ruohtula, T, Kondrashova, A, Lehtonen, J, Oikarinen, S, Hämäläinen, AM, Niemelä, O et al.. Immunomodulatory Effects of Rhinovirus and Enterovirus Infections During the First Year of Life. Front Immunol. 2020;11 :567046. doi: 10.3389/fimmu.2020.567046. PubMed PMID:33643278 PubMed Central PMC7905218.
  2. Salmikangas, S, Laiho, JE, Kalander, K, Laajala, M, Honkimaa, A, Shanina, I et al.. Detection of Viral -RNA and +RNA Strands in Enterovirus-Infected Cells and Tissues. Microorganisms. 2020;8 (12):. doi: 10.3390/microorganisms8121928. PubMed PMID:33291747 PubMed Central PMC7761939.
  3. Vari, HK, Roslund, MI, Oikarinen, S, Nurminen, N, Puhakka, R, Parajuli, A et al.. Associations between land cover categories, gaseous PAH levels in ambient air and endocrine signaling predicted from gut bacterial metagenome of the elderly. Chemosphere. 2021;265 :128965. doi: 10.1016/j.chemosphere.2020.128965. PubMed PMID:33248729 .
  4. Honkimaa, A, Kimura, B, Sioofy-Khojine, AB, Lin, J, Laiho, J, Oikarinen, S et al.. Genetic Adaptation of Coxsackievirus B1 during Persistent Infection in Pancreatic Cells. Microorganisms. 2020;8 (11):. doi: 10.3390/microorganisms8111790. PubMed PMID:33203081 PubMed Central PMC7697981.
  5. Liu, Z, Fan, YM, Ashorn, P, Cheung, YB, Hallamaa, L, Hyöty, H et al.. Faecal regenerating 1B protein concentration is not associated with child growth in rural Malawi. J Paediatr Child Health. 2021;57 (3):388-394. doi: 10.1111/jpc.15231. PubMed PMID:33112481 .
  6. Roslund, MI, Puhakka, R, Grönroos, M, Nurminen, N, Oikarinen, S, Gazali, AM et al.. Biodiversity intervention enhances immune regulation and health-associated commensal microbiota among daycare children. Sci Adv. 2020;6 (42):. doi: 10.1126/sciadv.aba2578. PubMed PMID:33055153 PubMed Central PMC7556828.
  7. Oikarinen, M, Bertolet, L, Toniolo, A, Oikarinen, S, Laiho, JE, Pugliese, A et al.. Differential Detection of Encapsidated versus Unencapsidated Enterovirus RNA in Samples Containing Pancreatic Enzymes-Relevance for Diabetes Studies. Viruses. 2020;12 (7):. doi: 10.3390/v12070747. PubMed PMID:32664501 PubMed Central PMC7411921.
  8. Vehik, K, Bonifacio, E, Lernmark, Å, Yu, L, Williams, A, Schatz, D et al.. Hierarchical Order of Distinct Autoantibody Spreading and Progression to Type 1 Diabetes in the TEDDY Study. Diabetes Care. 2020;43 (9):2066-2073. doi: 10.2337/dc19-2547. PubMed PMID:32641373 PubMed Central PMC7440899.
  9. Honkimaa, A, Sioofy-Khojine, AB, Oikarinen, S, Bertin, A, Hober, D, Hyöty, H et al.. Eradication of persistent coxsackievirus B infection from a pancreatic cell line with clinically used antiviral drugs. J Clin Virol. 2020;128 :104334. doi: 10.1016/j.jcv.2020.104334. PubMed PMID:32450550 .
  10. Sane, F, Bertin, A, Sioofy-Khojine, AB, Oikarinen, S, Alidjinou, EK, Veijola, R et al.. Enhancing and neutralizing anti-coxsackievirus activities in serum samples from patients prior to development of type 1 diabetes. Diabetes Metab Res Rev. 2020;36 (6):e3305. doi: 10.1002/dmrr.3305. PubMed PMID:32118346 .
  11. Seppälä, EM, Oikarinen, S, Lehtonen, JP, Neupane, S, Honkanen, H, Tyni, I et al.. Association of Picornavirus Infections With Acute Otitis Media in a Prospective Birth Cohort Study. J Infect Dis. 2020;222 (2):324-332. doi: 10.1093/infdis/jiaa087. PubMed PMID:32108877 .
  12. Li, Q, Parikh, H, Butterworth, MD, Lernmark, Å, Hagopian, W, Rewers, M et al.. Longitudinal Metabolome-Wide Signals Prior to the Appearance of a First Islet Autoantibody in Children Participating in the TEDDY Study. Diabetes. 2020;69 (3):465-476. doi: 10.2337/db19-0756. PubMed PMID:32029481 PubMed Central PMC7034190.
  13. Parajuli, A, Hui, N, Puhakka, R, Oikarinen, S, Grönroos, M, Selonen, VAO et al.. Yard vegetation is associated with gut microbiota composition. Sci Total Environ. 2020;713 :136707. doi: 10.1016/j.scitotenv.2020.136707. PubMed PMID:32019041 .
  14. Liu, X, Vehik, K, Huang, Y, Elding Larsson, H, Toppari, J, Ziegler, AG et al.. Distinct Growth Phases in Early Life Associated With the Risk of Type 1 Diabetes: The TEDDY Study. Diabetes Care. 2020;43 (3):556-562. doi: 10.2337/dc19-1670. PubMed PMID:31896601 PubMed Central PMC7035588.
  15. Hayes, A, Nguyen, D, Andersson, M, Antón, A, Bailly, JL, Beard, S et al.. A European multicentre evaluation of detection and typing methods for human enteroviruses and parechoviruses using RNA transcripts. J Med Virol. 2020;92 (8):1065-1074. doi: 10.1002/jmv.25659. PubMed PMID:31883139 PubMed Central PMC7496258.
  16. Lindfors, K, Lin, J, Lee, HS, Hyöty, H, Nykter, M, Kurppa, K et al.. Metagenomics of the faecal virome indicate a cumulative effect of enterovirus and gluten amount on the risk of coeliac disease autoimmunity in genetically at risk children: the TEDDY study. Gut. 2020;69 (8):1416-1422. doi: 10.1136/gutjnl-2019-319809. PubMed PMID:31744911 PubMed Central PMC7234892.

Search PubMed

2019

Hui N, Parajuli A, Puhakka R, Grönroos M, Roslund MI, Vari HK, Selonen VAO, Yan G, Siter N, Nurminen N, Oikarinen S, Laitinen OH, Rajaniemi J, Hyöty H, Sinkkonen A
Temporal variation in indoor transfer of dirt-associated environmental bacteria in agricultural and urban areas.
Environ Int ;2019
PMID

Lehto KM, Fan YM, Oikarinen S, Nurminen N, Hallamaa L, Juuti R, Mangani C, Maleta K, Hyöty H, Ashorn P
Presence of Giardia lamblia in stools of six- to 18-month old asymptomatic Malawians is associated with children’s growth failure.
Acta Paediatr ;108(10)1833-1840, 2019
PMID

Lietzén N, Hirvonen K, Honkimaa A, Buchacher T, Laiho JE, Oikarinen S, Mazur MA, Flodström-Tullberg M, Dufour E, Sioofy-Khojine AB, Hyöty H, Lahesmaa R
Coxsackievirus B Persistence Modifies the Proteome and the Secretome of Pancreatic Ductal Cells.
iScience ;2019
PMID

Fan YM, Oikarinen S, Lehto KM, Nurminen N, Juuti R, Mangani C, Maleta K, Hyöty H, Ashorn P
High prevalence of selected viruses and parasites and their predictors in Malawian children.
Epidemiol Infect ;2019
PMID

2018

Nurminen N, Lin J, Grönroos M, Puhakka R, Kramna L, Vari HK, Viskari H, Oikarinen S, Roslund M, Parajuli A, Tyni I, Cinek O, Laitinen O, Hyöty H, Sinkkonen A
Nature-derived microbiota exposure as a novel immunomodulatory approach.
Future Microbiol ;2018
PMID

Yassour M, Jason E, Hogstrom LJ, Arthur TD, Tripathi S, Siljander H, Selvenius J, Oikarinen S, Hyöty H, Virtanen SM, Ilonen J, Ferretti P, Pasolli E, Tett A, Asnicar F, Segata N, Vlamakis H, Lander ES, Huttenhower C, Knip M, Xavier RJ
Strain-Level Analysis of Mother-to-Child Bacterial Transmission during the First Few Months of Life.
Cell Host Microbe ;24(1)146-154.e4, 2018
PMID

Sioofy-Khojine AB, Lehtonen J, Nurminen N, Laitinen OH, Oikarinen S, Huhtala H, Pakkanen O, Ruokoranta T, Hankaniemi MM, Toppari J, Vähä-Mäkilä M, Ilonen J, Veijola R, Knip M, Hyöty H
Coxsackievirus B1 infections are associated with the initiation of insulin-driven autoimmunity that progresses to type 1 diabetes.
Diabetologia ;61(5)1193-1202, 2018
PMID

Stone VM, Hankaniemi MM, Svedin E, Sioofy-Khojine A, Oikarinen S, Hyöty H, Laitinen OH, Hytönen VP, Flodström-Tullberg M
A Coxsackievirus B vaccine protects against virus-induced diabetes in an experimental mouse model of type 1 diabetes.
Diabetologia ;61(2)476-481, 2018
PMID

Lietzen N, An LTT, Jaakkola MK, Kallionpää H, Oikarinen S, Mykkänen J, Knip M, Veijola R, Ilonen J, Toppari J, Hyöty H, Lahesmaa R, Elo LL
Enterovirus-associated changes in blood transcriptomic profiles of children with genetic susceptibility to type 1 diabetes.
Diabetologia ;61(2)381-388, 2018
PMID

Viskari H, Oikarinen S, Hoppu S, Vuorinen T, Huhtala H, Toppari J, Veijola R, Ilonen J, Knip M, Hyöty H
Live attenuated enterovirus vaccine (OPV) is not associated with islet autoimmunity in children with genetic susceptibility to type 1 diabetes: prospective cohort study.
Diabetologia ;61(1)203-209, 2018
PMID

2017

Cinek O, Kramna L, Lin J, Oikarinen S, Kolarova K, Ilonen J, Simell O, Veijola R, Autio R, Hyöty H
Imbalance of bacteriome profiles within the Finnish Diabetes Prediction and Prevention study: Parallel use of 16S profiling and virome sequencing in stool samples from children with islet autoimmunity and matched controls.
Pediatr Diabetes ;18(7)588-598, 2017
PMID

Honkanen H, Oikarinen S, Nurminen N, Laitinen OH, Huhtala H, Lehtonen J, Ruokoranta T, Hankaniemi MM, Lecouturier V, Almond JW, Tauriainen S, Simell O, Ilonen J, Veijola R, Viskari H, Knip M, Hyöty H
Detection of enteroviruses in stools precedes islet autoimmunity by several months: possible evidence for slowly operating mechanisms in virus-induced autoimmunity.
Diabetologia ;60(3)424-431, 2017
PMID

2016

Seppälä E, Sillanpää S, Nurminen N, Huhtala H, Toppari J, Ilonen J, Veijola R, Knip M, Sipilä M, Laranne J, Oikarinen S, Hyöty H
Human enterovirus and rhinovirus infections are associated with otitis media in a prospective birth cohort study.
J Clin Virol ;2016
PMID

Sillanpää S, Oikarinen S, Sipilä M, Kramna L, Rautiainen M, Huhtala H, Aittoniemi J, Laranne J, Hyöty H, Cinek O
Moraxella catarrhalis Might Be More Common than Expected in Acute Otitis Media in Young Finnish Children.
J Clin Microbiol ;54(9)2373-9, 2016
PMID

2015

Blazevic V, Malm M, Salminen M, Oikarinen S, Hyöty H, Veijola R, Vesikari T
Multiple consecutive norovirus infections in the first 2 years of life.
Eur J Pediatr ;174(12)1679-83, 2015
PMID

Laiho JE, Oikarinen S, Oikarinen M, Larsson PG, Stone VM, Hober D, Oberste S, Flodström-Tullberg M, Isola J, Hyöty H
Application of bioinformatics in probe design enables detection of enteroviruses on different taxonomic levels by advanced in situ hybridization technology.
J Clin Virol ;2015
PMID

Nurminen N, Juuti R, Oikarinen S, Fan YM, Lehto KM, Mangani C, Maleta K, Ashorn P, Hyöty H
High-throughput multiplex quantitative polymerase chain reaction method for Giardia lamblia and Cryptosporidium species detection in stool samples.
Am J Trop Med Hyg ;92(6)1222-6, 2015
PMID

Kramná L, Kolářová K, Oikarinen S, Pursiheimo JP, Ilonen J, Simell O, Knip M, Veijola R, Hyöty H, Cinek O
Gut virome sequencing in children with early islet autoimmunity.
Diabetes Care ;38(5)930-3, 2015
PMID

Krogvold L, Edwin B, Buanes T, Frisk G, Skog O, Anagandula M, Korsgren O, Undlien D, Eike MC, Richardson SJ, Leete P, Morgan NG, Oikarinen S, Oikarinen M, Laiho JE, Hyöty H, Ludvigsson J, Hanssen KF, Dahl-Jørgensen K
Detection of a low-grade enteroviral infection in the islets of langerhans of living patients newly diagnosed with type 1 diabetes.
Diabetes ;64(5)1682-7, 2015
PMID

Sillanpää S, Oikarinen S, Sipilä M, Seppälä E, Nurminen N, Rautiainen M, Laranne J, Hyöty H
Human parechovirus as a minor cause of acute otitis media in children.
J Clin Virol ;2015
PMID