Our latest paper, authored by Jack Morikka et al, is now published in the Computational and Structural Biotechnology Journal.
In this study, our team has investigated how much information might we be missing when performing the transcriptomics analysis of a system exposed to just a single concentration of a compound versus a control. Might we be overlooking important dose-dependent dynamics?
By treating macrophages with multiple concentrations of a profibrotic compound, over multiple timepoints, we uncovered a sustained, dose-dependent transcriptomic immune signature.
This study emphasizes the importance of using multiple concentrations in mechanistic analyses and introduces a toxicogenomic framework for evaluating the immunotoxic potential of chemical exposures.
The publication is available for reading here.
Big congratulations to everyone who contributed to this part of science!