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FHAIVE

Finnish Hub for Development and Validation of Integrated Approaches

PROJECTS

Ongoing research projects of FHAIVE

ARCHIMEDES – Data-Driven Integrated Approaches to Chemical Safety Assessment and Drug Design

Archimedes is a ERC-funded multidisciplinary project, supported by Tampere University, aiming to make products safe for consumers, while reducing the number of animals in the experiments. In the work, integration of wet lab and bioinformatics enables goals as new integrated testing approaches to be developed, as well as to establish new paradigm in chemical safety assessment and biomedical data framework covering toxicology and pharmacology. Project is ongoing in the period from 2022-2026. More information could be found here.

LiverTarget – A new generation of advanced RNA therapeutics

LiverTarget is EU funded project aiming to develop an innovative RNA inhibition and activation therapeutics against cardiovascular and metabolic diseases by targeting ceramide synthesis and inflammatory cascades in the liver. Project goals are numerous, focusing on generating innovative siRNA pools and synthetic mRNAs to regulate ceramide and inflammatory targets in the liver; formulating them in established human-approved liver-targeting lipid nanoparticles (LNP); determining their efficiency invivo; and completing safety and toxicology evaluation of the most promising lead candidates. FAHIE contributes by developing and pre-clinical testing of siRNA drugs. Project is ongoing for the period from 2022-2027. More information could be found here.

SCENARIOS

Scenarios is project funded by EU Horizon 2020. The project aims to develop new knowledge and technology in PFAS toxicology; detect and remove PFAS contaminants from soil and drinking water; develop integrated approached to testing and assessment (IATA) of PFAS; and assist EU countries and institutions in decision-making regarding environmental safety and human health. FHAIVE is putting effort in contributing the IATA of PFAS toxicity. Project is ongoing in the period from 2022-2026. More information could be found here.

CompSafeNano

CompSafeNano is a RISE project funded by the EU’s Marie Skłodowska-Curie Actions Excellent Science Program. The project aims to develop universally applicable and integrated nanoinformatic models in industry, enterprises and regulatory bodies focusing especially on risk assessment and decision-making. As well as establishing a network of scientists and knowledge base of the alternative testing methodologies is an important goal. Project is divided in 8 work packages, including, molecular stimulation, structure property AI/ML; toxicogenomic modelling; toxicity assessment; as well as case studies testing, cloud platforms and databases, training and knowledge dissemination, and project management. FHAIVE has the responsibility of supporting program for the development of IATA for the nanomaterial safety assessment. Project is ongoing in the period from 2021-2024. More information could be found here.

Finnish 3R Center – FIN3RC

FIN3R is a cooperation forum for universities, research institutes, authorities and industry that promotes the 3Rs in research and education. The objective is to promote development and use of methods and strategies based on the 3Rs in education and scientific research as well in animal breeding and keeping. This will be accomplished by increasing education and training of the researchers on 3R methods, further the development of these methods, and dissemination of the best practices and information for the researchers. In addition, FIN3R organizes educational events, such as webinars, workshops and symposiums to build a national and international network of the scientists using 3R principles in their work. Project is funded and supervised by TOKES, Council on the Protection of Animals Used for Scientific or Educational Purposes, within the Ministry of Agriculture and Forestry of Finland. The project is ongoing for the period from 2021-2026. More information could be found here.

BIOMAP

Biomap is a project aiming to examine the causes and mechanisms of atopic dermatitis and psoriasis by identifying the biomarkers responsible for the variation in disease outcome. The project aims to indicate the main causes of the diseases as well as its development process; establish pan-European BioResource for research and Clinical Research Network; and predict models and biomarkers of the diseases outcomes and identify disease subtypes. Funding is provided by EU Horizon 2020, Innovative Medicines Initiative (IMI) and European Federation of Pharmaceutical Industries and Associations (EFPIA). Project is ongoing in the period from 2019-2023. More information could be found here.

NanoSolveIT

NanoSolveIT is a EU Horizon 2020-funded project. The project aims to develop a validated tiered IATA to identify the critical characteristics of nanomaterials responsible for their adverse effects on human health and the environment or for their functionalities in high-tech applications. Goals of the project are: harmonization, curation and FAIRification of the already existing data; development methodology for insilico prediction of the nanomaterials toxicity; implementation of the NM fingerprints concept; contribute to reduction of animals used in the experiments; establishment of the NanoSolveIT IATA and its platform to serve as an information source. Project is ongoing for the period from 2019-2023. More information could be found here.

Completed research projects of FHAIVE

  • NextCast: funded by Novo Nordisk Foundation; ongoing in 2021.
  • caLIBRAte: funded by EU CORDIS; ongoing from 2016-2021
  • UNICAST NANO: funded by Academy of Finland (AKA); ongoing from 2019-2023
  • NanoInformaTIX: funded by EU Horizon2020; ongoing from 2019-2023