Publications

2022

  1. Prajapati, C, Koivumäki, J, Pekkanen-Mattila, M, Aalto-Setälä, K. Sex differences in heart: from basics to clinics. Eur J Med Res. 2022;27 (1):241. doi: 10.1186/s40001-022-00880-z. PubMed PMID:36352432 PubMed Central PMC9647968.
  2. Rodosthenous, RS, Niemi, MEK, Kallio, L, Perala, M, Terho, P, Knopp, T et al.. Recontacting biobank participants to collect lifestyle, behavioural and cognitive information via online questionnaires: lessons from a pilot study within FinnGen. BMJ Open. 2022;12 (10):e064695. doi: 10.1136/bmjopen-2022-064695. PubMed PMID:36198465 PubMed Central PMC9535212.
  3. Maria Cherian, R, Prajapati, C, Penttinen, K, Häkli, M, Koivisto, JT, Pekkanen-Mattila, M et al.. Fluorescent hiPSC-derived MYH6-mScarlet cardiomyocytes for real-time tracking, imaging, and cardiotoxicity assays. Cell Biol Toxicol. 2022; :. doi: 10.1007/s10565-022-09742-0. PubMed PMID:35870039 .
  4. Häkli, M, Jäntti, S, Joki, T, Sukki, L, Tornberg, K, Aalto-Setälä, K et al.. Human Neurons Form Axon-Mediated Functional Connections with Human Cardiomyocytes in Compartmentalized Microfluidic Chip. Int J Mol Sci. 2022;23 (6):. doi: 10.3390/ijms23063148. PubMed PMID:35328569 PubMed Central PMC8955890.
  5. Gaballah, M, Penttinen, K, Kreutzer, J, Mäki, AJ, Kallio, P, Aalto-Setälä, K et al.. Cardiac Ischemia On-a-Chip: Antiarrhythmic Effect of Levosimendan on Ischemic Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Cells. 2022;11 (6):. doi: 10.3390/cells11061045. PubMed PMID:35326497 PubMed Central PMC8947267.
  6. Tamlander, M, Mars, N, Pirinen, M, FinnGen, Widén, E, Ripatti, S et al.. Integration of questionnaire-based risk factors improves polygenic risk scores for human coronary heart disease and type 2 diabetes. Commun Biol. 2022;5 (1):158. doi: 10.1038/s42003-021-02996-0. PubMed PMID:35197564 PubMed Central PMC8866413.
  7. Saari, J, Siddique, F, Korpela, S, Mäntylä, E, Ihalainen, TO, Kaukinen, K et al.. Toward Xeno-Free Differentiation of Human Induced Pluripotent Stem Cell-Derived Small Intestinal Epithelial Cells. Int J Mol Sci. 2022;23 (3):. doi: 10.3390/ijms23031312. PubMed PMID:35163236 PubMed Central PMC8835723.
  8. Juhola, M, Joutsijoki, H, Penttinen, K, Shah, D, Pölönen, RP, Aalto-Setälä, K et al.. Data analytics for cardiac diseases. Comput Biol Med. 2022;142 :105218. doi: 10.1016/j.compbiomed.2022.105218. PubMed PMID:34999413 .

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2021

  1. Juhola, M, Joutsijoki, H, Penttinen, K, Shah, D, Aalto-Setälä, K. On computational classification of genetic cardiac diseases applying iPSC cardiomyocytes. Comput Methods Programs Biomed. 2021;210 :106367. doi: 10.1016/j.cmpb.2021.106367. PubMed PMID:34474196 .
  2. Marttila, S, Viiri, LE, Mishra, PP, Kühnel, B, Matias-Garcia, PR, Lyytikäinen, LP et al.. Methylation status of nc886 epiallele reflects periconceptional conditions and is associated with glucose metabolism through nc886 RNAs. Clin Epigenetics. 2021;13 (1):143. doi: 10.1186/s13148-021-01132-3. PubMed PMID:34294131 PubMed Central PMC8296652.
  3. Häkli, M, Kreutzer, J, Mäki, AJ, Välimäki, H, Lappi, H, Huhtala, H et al.. Human induced pluripotent stem cell-based platform for modeling cardiac ischemia. Sci Rep. 2021;11 (1):4153. doi: 10.1038/s41598-021-83740-w. PubMed PMID:33603154 PubMed Central PMC7893031.
  4. Prajapati, C, Ojala, M, Lappi, H, Aalto-Setälä, K, Pekkanen-Mattila, M. Electrophysiological evaluation of human induced pluripotent stem cell-derived cardiomyocytes obtained by different methods. Stem Cell Res. 2021;51 :102176. doi: 10.1016/j.scr.2021.102176. PubMed PMID:33485184 .
  5. Juhola, M, Penttinen, K, Joutsijoki, H, Aalto-Setälä, K. Analysis of Drug Effects on iPSC Cardiomyocytes with Machine Learning. Ann Biomed Eng. 2021;49 (1):129-138. doi: 10.1007/s10439-020-02521-0. PubMed PMID:32367466 PubMed Central PMC7773623.

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2020

  1. Zelnik, ID, Volpert, G, Viiri, LE, Kauhanen, D, Arazi, T, Aalto-Setälä, K et al.. Different rates of flux through the biosynthetic pathway for long-chain versus very-long-chain sphingolipids. J Lipid Res. 2020;61 (10):1341-1346. doi: 10.1194/jlr.RA120000984. PubMed PMID:32651186 PubMed Central PMC7529049.
  2. Välimäki, H, Hyvärinen, T, Leivo, J, Iftikhar, H, Pekkanen-Mattila, M, Rajan, DK et al.. Covalent immobilization of luminescent oxygen indicators reduces cytotoxicity. Biomed Microdevices. 2020;22 (2):41. doi: 10.1007/s10544-020-00495-3. PubMed PMID:32494857 PubMed Central PMC7270993.
  3. Shah, D, Prajapati, C, Penttinen, K, Cherian, RM, Koivumäki, JT, Alexanova, A et al.. hiPSC-Derived Cardiomyocyte Model of LQT2 Syndrome Derived from Asymptomatic and Symptomatic Mutation Carriers Reproduces Clinical Differences in Aggregates but Not in Single Cells. Cells. 2020;9 (5):. doi: 10.3390/cells9051153. PubMed PMID:32392813 PubMed Central PMC7290503.
  4. Juhola, M, Penttinen, K, Joutsijoki, H, Aalto-Setälä, K. Analysis of Drug Effects on iPSC Cardiomyocytes with Machine Learning. Ann Biomed Eng. 2021;49 (1):129-138. doi: 10.1007/s10439-020-02521-0. PubMed PMID:32367466 PubMed Central PMC7773623.
  5. Heliö, K, Kangas-Kontio, T, Weckström, S, Vanninen, SUM, Aalto-Setälä, K, Alastalo, TP et al.. DSP p.(Thr2104Glnfs*12) variant presents variably with early onset severe arrhythmias and left ventricular cardiomyopathy. BMC Med Genet. 2020;21 (1):19. doi: 10.1186/s12881-020-0955-z. PubMed PMID:32005173 PubMed Central PMC6995042.
  6. Calejo, MT, Saari, J, Vuorenpää, H, Vuorimaa-Laukkanen, E, Kallio, P, Aalto-Setälä, K et al.. Co-culture of human induced pluripotent stem cell-derived retinal pigment epithelial cells and endothelial cells on double collagen-coated honeycomb films. Acta Biomater. 2020;101 :327-343. doi: 10.1016/j.actbio.2019.11.002. PubMed PMID:31711900 .
  7. Kreutzer, J, Viehrig, M, Pölönen, RP, Zhao, F, Ojala, M, Aalto-Setälä, K et al.. Pneumatic unidirectional cell stretching device for mechanobiological studies of cardiomyocytes. Biomech Model Mechanobiol. 2020;19 (1):291-303. doi: 10.1007/s10237-019-01211-8. PubMed PMID:31444593 PubMed Central PMC7005075.

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2019

  1. Joutsijoki, H, Penttinen, K, Juhola, M, Aalto-Setälä, K. Separation of HCM and LQT Cardiac Diseases with Machine Learning of Ca2+ Transient Profiles. Methods Inf Med. 2019;58 (4-05):167-178. doi: 10.1055/s-0040-1701484. PubMed PMID:32079026 .
  2. Calejo, MT, Saari, J, Vuorenpää, H, Vuorimaa-Laukkanen, E, Kallio, P, Aalto-Setälä, K et al.. Co-culture of human induced pluripotent stem cell-derived retinal pigment epithelial cells and endothelial cells on double collagen-coated honeycomb films. Acta Biomater. 2020;101 :327-343. doi: 10.1016/j.actbio.2019.11.002. PubMed PMID:31711900 .
  3. Kreutzer, J, Viehrig, M, Pölönen, RP, Zhao, F, Ojala, M, Aalto-Setälä, K et al.. Pneumatic unidirectional cell stretching device for mechanobiological studies of cardiomyocytes. Biomech Model Mechanobiol. 2020;19 (1):291-303. doi: 10.1007/s10237-019-01211-8. PubMed PMID:31444593 PubMed Central PMC7005075.
  4. Kiamehr, M, Klettner, A, Richert, E, Koskela, A, Koistinen, A, Skottman, H et al.. Compromised Barrier Function in Human Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells from Type 2 Diabetic Patients. Int J Mol Sci. 2019;20 (15):. doi: 10.3390/ijms20153773. PubMed PMID:31375001 PubMed Central PMC6696227.
  5. Shah, D, Virtanen, L, Prajapati, C, Kiamehr, M, Gullmets, J, West, G et al.. Modeling of LMNA-Related Dilated Cardiomyopathy Using Human Induced Pluripotent Stem Cells. Cells. 2019;8 (6):. doi: 10.3390/cells8060594. PubMed PMID:31208058 PubMed Central PMC6627421.
  6. Kiamehr, M, Heiskanen, L, Laufer, T, Düsterloh, A, Kahraman, M, Käkelä, R et al.. Dedifferentiation of Primary Hepatocytes is Accompanied with Reorganization of Lipid Metabolism Indicated by Altered Molecular Lipid and miRNA Profiles. Int J Mol Sci. 2019;20 (12):. doi: 10.3390/ijms20122910. PubMed PMID:31207892 PubMed Central PMC6627955.
  7. Pekkanen-Mattila, M, Häkli, M, Pölönen, RP, Mansikkala, T, Junnila, A, Talvitie, E et al.. Polyethylene Terephthalate Textiles Enhance the Structural Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Materials (Basel). 2019;12 (11):. doi: 10.3390/ma12111805. PubMed PMID:31163704 PubMed Central PMC6600740.
  8. Koivisto, JT, Gering, C, Karvinen, J, Maria Cherian, R, Belay, B, Hyttinen, J et al.. Mechanically Biomimetic Gelatin-Gellan Gum Hydrogels for 3D Culture of Beating Human Cardiomyocytes. ACS Appl Mater Interfaces. 2019;11 (23):20589-20602. doi: 10.1021/acsami.8b22343. PubMed PMID:31120238 PubMed Central PMC6750838.
  9. Kim, J, Shah, D, Potapov, I, Latukka, J, Aalto-Setälä, K, Räsänen, E et al.. Scaling and correlation properties of RR and QT intervals at the cellular level. Sci Rep. 2019;9 (1):3651. doi: 10.1038/s41598-019-40247-9. PubMed PMID:30842620 PubMed Central PMC6403385.
  10. Viiri, LE, Rantapero, T, Kiamehr, M, Alexanova, A, Oittinen, M, Viiri, K et al.. Extensive reprogramming of the nascent transcriptome during iPSC to hepatocyte differentiation. Sci Rep. 2019;9 (1):3562. doi: 10.1038/s41598-019-39215-0. PubMed PMID:30837492 PubMed Central PMC6401154.
  11. Jääskeläinen, P, Vangipurapu, J, Raivo, J, Kuulasmaa, T, Heliö, T, Aalto-Setälä, K et al.. Genetic basis and outcome in a nationwide study of Finnish patients with hypertrophic cardiomyopathy. ESC Heart Fail. 2019;6 (2):436-445. doi: 10.1002/ehf2.12420. PubMed PMID:30775854 PubMed Central PMC6437444.
  12. Kiamehr, M, Alexanova, A, Viiri, LE, Heiskanen, L, Vihervaara, T, Kauhanen, D et al.. hiPSC-derived hepatocytes closely mimic the lipid profile of primary hepatocytes: A future personalised cell model for studying the lipid metabolism of the liver. J Cell Physiol. 2019;234 (4):3744-3761. doi: 10.1002/jcp.27131. PubMed PMID:30146765 .

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2018

  1. Potapov, I, Latukka, J, Kim, J, Luukko, P, Aalto-Setälä, K, Räsänen, E et al.. Information transfer in QT-RR dynamics: Application to QT-correction. Sci Rep. 2018;8 (1):14992. doi: 10.1038/s41598-018-33359-1. PubMed PMID:30301929 PubMed Central PMC6178346.
  2. Vanninen, SUM, Leivo, K, Seppälä, EH, Aalto-Setälä, K, Pitkänen, O, Suursalmi, P et al.. Heterozygous junctophilin-2 (JPH2) p.(Thr161Lys) is a monogenic cause for HCM with heart failure. PLoS One. 2018;13 (9):e0203422. doi: 10.1371/journal.pone.0203422. PubMed PMID:30235249 PubMed Central PMC6147424.
  3. Kiamehr, M, Alexanova, A, Viiri, LE, Heiskanen, L, Vihervaara, T, Kauhanen, D et al.. hiPSC-derived hepatocytes closely mimic the lipid profile of primary hepatocytes: A future personalised cell model for studying the lipid metabolism of the liver. J Cell Physiol. 2019;234 (4):3744-3761. doi: 10.1002/jcp.27131. PubMed PMID:30146765 .
  4. Paci, M, Pölönen, RP, Cori, D, Penttinen, K, Aalto-Setälä, K, Severi, S et al.. Automatic Optimization of an in Silico Model of Human iPSC Derived Cardiomyocytes Recapitulating Calcium Handling Abnormalities. Front Physiol. 2018;9 :709. doi: 10.3389/fphys.2018.00709. PubMed PMID:29997516 PubMed Central PMC6028769.
  5. Prajapati, C, Pölönen, RP, Aalto-Setälä, K. Simultaneous recordings of action potentials and calcium transients from human induced pluripotent stem cell derived cardiomyocytes. Biol Open. 2018;7 (7):. doi: 10.1242/bio.035030. PubMed PMID:29970475 PubMed Central PMC6078349.
  6. Juhola, M, Joutsijoki, H, Penttinen, K, Aalto-Setälä, K. Detection of genetic cardiac diseases by Ca2+ transient profiles using machine learning methods. Sci Rep. 2018;8 (1):9355. doi: 10.1038/s41598-018-27695-5. PubMed PMID:29921843 PubMed Central PMC6008430.
  7. Mäki, AJ, Verho, J, Kreutzer, J, Ryynänen, T, Rajan, D, Pekkanen-Mattila, M et al.. A Portable Microscale Cell Culture System with Indirect Temperature Control. SLAS Technol. 2018;23 (6):566-579. doi: 10.1177/2472630318768710. PubMed PMID:29723086 .
  8. Strässler, ET, Aalto-Setälä, K, Kiamehr, M, Landmesser, U, Kränkel, N. Age Is Relative-Impact of Donor Age on Induced Pluripotent Stem Cell-Derived Cell Functionality. Front Cardiovasc Med. 2018;5 :4. doi: 10.3389/fcvm.2018.00004. PubMed PMID:29423397 PubMed Central PMC5790033.
  9. Prajapati, C, Ojala, M, Aalto-Setälä, K. Divergent effects of adrenaline in human induced pluripotent stem cell-derived cardiomyocytes obtained from hypertrophic cardiomyopathy. Dis Model Mech. 2018;11 (2):. doi: 10.1242/dmm.032896. PubMed PMID:29361520 PubMed Central PMC5894949.

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