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Eye and Vision research

Publications

2024

  1. NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1108 population-representative studies with 141 million participants. Lancet. 2024; :. doi: 10.1016/S0140-6736(24)02317-1. PubMed PMID:39549716 .
  2. Salo, V, Määttä, J, Sliz, E, FinnGen, Reimann, E, Mägi, R et al.. Genome-wide meta-analysis conducted in three large biobanks expands the genetic landscape of lumbar disc herniations. Nat Commun. 2024;15 (1):9424. doi: 10.1038/s41467-024-53467-z. PubMed PMID:39511132 PubMed Central PMC11544010.
  3. Becker, S, Suija, K, Valpas, A, Koiranen, M, Auvinen, J, Uusitalo, H et al.. Erectile dysfunction as a predictive indicator of asymptomatic diabetes and prediabetes. Prim Care Diabetes. 2024; :. doi: 10.1016/j.pcd.2024.09.008. PubMed PMID:39393949 .
  4. Viheriälä, T, Hongisto, H, Saari, L, Oksanen, M, Ilmarinen, T, Väärämäki, S et al.. Novel Human Induced Pluripotent Stem Cell-Based Model for Retinal Pigment Epithelial Cells to Reveal Possible Disease Mechanisms for Macular Degeneration in Pseudoxanthoma Elasticum. J Ophthalmol. 2024;2024 :6939920. doi: 10.1155/2024/6939920. PubMed PMID:39347541 PubMed Central PMC11438508.
  5. Mosallaei, P, Purola, P, Tolkkinen, L, Gissler, M, Uusitalo, H. The incidence of visual impairment due to retinitis pigmentosa has declined in Finland over the last 40 years. Acta Ophthalmol. 2024; :. doi: 10.1111/aos.16757. PubMed PMID:39329444 .
  6. Pasanen, A, Karjalainen, MK, Korppi, M, Hallman, M, Rämet, M, Research Project FinnGen
    et al.. Genetic susceptibility to acute viral bronchiolitis. J Infect Dis. 2024; :. doi: 10.1093/infdis/jiae467. PubMed PMID:39299705 .
  7. NCD Risk Factor Collaboration (NCD-RisC). General and abdominal adiposity and hypertension in eight world regions: a pooled analysis of 837 population-based studies with 7·5 million participants. Lancet. 2024;404 (10455):851-863. doi: 10.1016/S0140-6736(24)01405-3. PubMed PMID:39216975 PubMed Central PMC7616775.
  8. Kohvakka, A, Sattari, M, Nättinen, J, Aapola, U, Gregorová, P, Tammela, TLJ et al.. Long noncoding RNA EPCART regulates translation through PI3K/AKT/mTOR pathway and PDCD4 in prostate cancer. Cancer Gene Ther. 2024;31 (10):1536-1546. doi: 10.1038/s41417-024-00822-3. PubMed PMID:39147845 PubMed Central PMC11489079.
  9. Vuoksimaa, E, Saari, TT, Aaltonen, A, Aaltonen, S, Herukka, SK, Iso-Markku, P et al.. TWINGEN: protocol for an observational clinical biobank recall and biomarker cohort study to identify Finnish individuals with high risk of Alzheimer’s disease. BMJ Open. 2024;14 (6):e081947. doi: 10.1136/bmjopen-2023-081947. PubMed PMID:38866570 PubMed Central PMC11177688.
  10. NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults. Lancet. 2024;403 (10431):1027-1050. doi: 10.1016/S0140-6736(23)02750-2. PubMed PMID:38432237 PubMed Central PMC7615769.
  11. Mars, N, Kerminen, S, Tamlander, M, Pirinen, M, Jakkula, E, Aaltonen, K et al.. Comprehensive Inherited Risk Estimation for Risk-Based Breast Cancer Screening in Women. J Clin Oncol. 2024;42 (13):1477-1487. doi: 10.1200/JCO.23.00295. PubMed PMID:38422475 PubMed Central PMC11095905.
  12. Mäkinen, P, Nättinen, J, Aapola, U, Pietilä, J, Uusitalo, H. Comparison of early changes in tear film protein profiles after small incision lenticule extraction (SMILE) and femtosecond LASIK (FS-LASIK) surgery. Clin Proteomics. 2024;21 (1):11. doi: 10.1186/s12014-024-09460-1. PubMed PMID:38368345 PubMed Central PMC10874072.
  13. Youssef, O, Loukola, A, Zidi-Mouaffak, YHS, Tamlander, M, Ruotsalainen, S, Kilpeläinen, E et al.. High-Resolution Genotyping of Formalin-Fixed Tissue Accurately Estimates Polygenic Risk Scores in Human Diseases. Lab Invest. 2024;104 (4):100325. doi: 10.1016/j.labinv.2024.100325. PubMed PMID:38220043 .
  14. Nurkkala, JM, Aittokallio, J, FinnGen
    , Kauko, A, Niiranen, T. Sex-specific genetic risks for adverse outcomes after coronary revascularization procedures. Interdiscip Cardiovasc Thorac Surg. 2024;38 (1):. doi: 10.1093/icvts/ivae006. PubMed PMID:38216540 PubMed Central PMC10799751.
  15. Purola, P, Koskinen, S, Uusitalo, H. Nationwide and regional trends in distance and near visual acuities during 2000-2017 in Finland. Acta Ophthalmol. 2024;102 (4):483-490. doi: 10.1111/aos.15784. PubMed PMID:37772430 .
  16. Mäkelä, E, Venesvirta, H, Ilves, M, Lylykangas, J, Rantanen, V, Uusitalo, H et al.. Electrically Induced Blink for the Prevention of Ocular Symptoms and Blurred Vision in Patients With Acute Facial Nerve Palsy. Ear Nose Throat J. 2024;103 (5):NP294-NP300. doi: 10.1177/01455613211048576. PubMed PMID:34714168 .

Search PubMed

2023

  1. Purola, PKM, Taipale, J, Väätäinen, S, Harju, M, Koskinen, SVP, Uusitalo, HMT et al.. Price tag of glaucoma care is minor compared with the total direct and indirect costs of glaucoma: Results from nationwide survey and register data. PLoS One. 2023;18 (12):e0295523. doi: 10.1371/journal.pone.0295523. PubMed PMID:38117760 PubMed Central PMC10732367.
  2. Nurmi, AK, Pelttari, LM, Kiiski, JI, Khan, S, Nurmikolu, M, Suvanto, M et al.. NTHL1 is a recessive cancer susceptibility gene. Sci Rep. 2023;13 (1):21127. doi: 10.1038/s41598-023-47441-w. PubMed PMID:38036545 PubMed Central PMC10689455.
  3. Liuska, PJ, Rämö, JT, Lemmelä, S, Kaarniranta, K, Uusitalo, H, Lahtela, E et al.. Association of APOE Haplotypes With Common Age-Related Ocular Diseases in 412,171 Individuals. Invest Ophthalmol Vis Sci. 2023;64 (14):33. doi: 10.1167/iovs.64.14.33. PubMed PMID:37988105 PubMed Central PMC10668614.
  4. NCD Risk Factor Collaboration (NCD-RisC). Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c. Nat Med. 2023;29 (11):2885-2901. doi: 10.1038/s41591-023-02610-2. PubMed PMID:37946056 PubMed Central PMC10667106.
  5. Purola, P, Koskinen, S, Uusitalo, H. Nationwide and regional trends in distance and near visual acuities during 2000-2017 in Finland. Acta Ophthalmol. 2024;102 (4):483-490. doi: 10.1111/aos.15784. PubMed PMID:37772430 .
  6. Julkunen, V, Schwarz, C, Kalapudas, J, Hallikainen, M, Piironen, AK, Mannermaa, A et al.. A FinnGen pilot clinical recall study for Alzheimer’s disease. Sci Rep. 2023;13 (1):12641. doi: 10.1038/s41598-023-39835-7. PubMed PMID:37537264 PubMed Central PMC10400697.
  7. Viippola, E, Kuitunen, S, Rodosthenous, RS, Vabalas, A, Hartonen, T, Vartiainen, P et al.. Data Resource Profile: Nationwide registry data for high-throughput epidemiology and machine learning (FinRegistry). Int J Epidemiol. 2023;52 (4):e195-e200. doi: 10.1093/ije/dyad091. PubMed PMID:37365732 PubMed Central PMC10396416.
  8. Ågren, R, Patil, S, Zhou, X, FinnGen., Sahlholm, K, Pääbo, S et al.. Major Genetic Risk Factors for Dupuytren’s Disease Are Inherited From Neandertals. Mol Biol Evol. 2023;40 (6):. doi: 10.1093/molbev/msad130. PubMed PMID:37315093 PubMed Central PMC10266526.
  9. Jones, SE, Maisha, FI, Strausz, SJ, Lammi, V, Cade, BE, Tervi, A et al.. The public health impact of poor sleep on severe COVID-19, influenza and upper respiratory infections. EBioMedicine. 2023;93 :104630. doi: 10.1016/j.ebiom.2023.104630. PubMed PMID:37301713 PubMed Central PMC10248098.
  10. Tyrmi, JS, Kaartokallio, T, Lokki, AI, Jääskeläinen, T, Kortelainen, E, Ruotsalainen, S et al.. Genetic Risk Factors Associated With Preeclampsia and Hypertensive Disorders of Pregnancy. JAMA Cardiol. 2023;8 (7):674-683. doi: 10.1001/jamacardio.2023.1312. PubMed PMID:37285119 PubMed Central PMC10248811.
  11. Puhakka, N, Das Gupta, S, Leskinen, S, Heiskanen, M, Nättinen, J, Aapola, U et al.. Proteomics of Deep Cervical Lymph Nodes After Experimental Traumatic Brain Injury. Neurotrauma Rep. 2023;4 (1):359-366. doi: 10.1089/neur.2023.0008. PubMed PMID:37284699 PubMed Central PMC10240307.
  12. Miller, EC, Kauko, A, Tom, SE, Laivuori, H, Niiranen, T, Bello, NA et al.. Risk of Midlife Stroke After Adverse Pregnancy Outcomes: The FinnGen Study. Stroke. 2023;54 (7):1798-1805. doi: 10.1161/STROKEAHA.123.043052. PubMed PMID:37212139 PubMed Central PMC10330298.
  13. Ollila, HM, Sharon, E, Lin, L, Sinnott-Armstrong, N, Ambati, A, Yogeshwar, SM et al.. Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy. Nat Commun. 2023;14 (1):2709. doi: 10.1038/s41467-023-36120-z. PubMed PMID:37188663 PubMed Central PMC10185546.
  14. Vähätupa, M, Nättinen, J, Aapola, U, Uusitalo-Järvinen, H, Uusitalo, H, Järvinen, TAH et al.. Proteomics Analysis of R-Ras Deficiency in Oxygen Induced Retinopathy. Int J Mol Sci. 2023;24 (9):. doi: 10.3390/ijms24097914. PubMed PMID:37175621 PubMed Central PMC10178533.
  15. Purola, P, Koskinen, S, Uusitalo, H. Impact of vision on generic health-related quality of life – A systematic review. Acta Ophthalmol. 2023;101 (7):717-728. doi: 10.1111/aos.15676. PubMed PMID:37032474 .
  16. NCD Risk Factor Collaboration (NCD-RisC). Diminishing benefits of urban living for children and adolescents’ growth and development. Nature. 2023;615 (7954):874-883. doi: 10.1038/s41586-023-05772-8. PubMed PMID:36991188 PubMed Central PMC10060164.
  17. Sliz, E, Tyrmi, JS, Rahmioglu, N, Zondervan, KT, Becker, CM, FinnGen et al.. Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata. Nat Commun. 2023;14 (1):542. doi: 10.1038/s41467-023-35974-7. PubMed PMID:36726022 PubMed Central PMC9892568.
  18. Purola, PKM, Koskinen, SVP, Uusitalo, HMT. Comparison of three health-related quality of life instruments in relation to visual acuity: EQ-5D, 15D, and EUROHIS-QOL8. Qual Life Res. 2023;32 (2):543-552. doi: 10.1007/s11136-022-03293-x. PubMed PMID:36385360 PubMed Central PMC9911483.
  19. Purola, P, Kaarniranta, K, Ojamo, M, Gissler, M, Uusitalo, H. Visual impairment due to age-related macular degeneration during 40 years in Finland and the impact of novel therapies. Acta Ophthalmol. 2023;101 (1):57-64. doi: 10.1111/aos.15224. PubMed PMID:35912685 PubMed Central PMC10087211.
  20. Välimäki, J, Nukareddy, P, Uusitalo, H, Aapola, U. Intraluminal deposits: A rare cause of glaucoma drainage implant total obstruction. Eur J Ophthalmol. 2023;33 (1):307-311. doi: 10.1177/11206721221100074. PubMed PMID:35575733 .

Search PubMed

2022

  1. Parkkari, M, Purola, P, Uusitalo, H. Ocular surface disease signs and symptoms of glaucoma patients and their relation to glaucoma medication in Finland. Eur J Ophthalmol. 2022;33 (2):11206721221144339. doi: 10.1177/11206721221144339. PubMed PMID:36511236 PubMed Central PMC9999283.
  2. Purola, PKM, Koskinen, SVP, Uusitalo, HMT. Comparison of three health-related quality of life instruments in relation to visual acuity: EQ-5D, 15D, and EUROHIS-QOL8. Qual Life Res. 2023;32 (2):543-552. doi: 10.1007/s11136-022-03293-x. PubMed PMID:36385360 PubMed Central PMC9911483.
  3. Rodosthenous, RS, Niemi, MEK, Kallio, L, Perala, M, Terho, P, Knopp, T et al.. Recontacting biobank participants to collect lifestyle, behavioural and cognitive information via online questionnaires: lessons from a pilot study within FinnGen. BMJ Open. 2022;12 (10):e064695. doi: 10.1136/bmjopen-2022-064695. PubMed PMID:36198465 PubMed Central PMC9535212.
  4. Ruotsalainen, SE, Surakka, I, Mars, N, Karjalainen, J, Kurki, M, Kanai, M et al.. Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis. Commun Biol. 2022;5 (1):802. doi: 10.1038/s42003-022-03552-0. PubMed PMID:35978133 PubMed Central PMC9385630.
  5. Purola, P, Kaarniranta, K, Ojamo, M, Gissler, M, Uusitalo, H. Visual impairment due to age-related macular degeneration during 40 years in Finland and the impact of novel therapies. Acta Ophthalmol. 2023;101 (1):57-64. doi: 10.1111/aos.15224. PubMed PMID:35912685 PubMed Central PMC10087211.
  6. Nättinen, J, Aapola, U, Nukareddy, P, Uusitalo, H. Clinical Tear Fluid Proteomics-A Novel Tool in Glaucoma Research. Int J Mol Sci. 2022;23 (15):. doi: 10.3390/ijms23158136. PubMed PMID:35897711 PubMed Central PMC9331117.
  7. Saunajoki, A, Auvinen, J, Bloigu, A, Saramies, J, Tuomilehto, J, Uusitalo, H et al.. Elevated One-Hour Post-Load Glucose Is Independently Associated with Albuminuria: A Cross-Sectional Population Study. J Clin Med. 2022;11 (14):. doi: 10.3390/jcm11144124. PubMed PMID:35887888 PubMed Central PMC9317539.
  8. Purola, PKM, Ojamo, MUI, Gissler, M, Uusitalo, HMT. Changes in Visual Impairment due to Diabetic Retinopathy During 1980-2019 Based on Nationwide Register Data. Diabetes Care. 2022;45 (9):2020-2027. doi: 10.2337/dc21-2369. PubMed PMID:35838317 PubMed Central PMC9472510.
  9. Muilu-Mäkelä, R, Aapola, U, Tienaho, J, Uusitalo, H, Sarjala, T. Antibacterial and Oxidative Stress-Protective Effects of Five Monoterpenes from Softwood. Molecules. 2022;27 (12):. doi: 10.3390/molecules27123891. PubMed PMID:35745011 PubMed Central PMC9230896.
  10. Välimäki, J, Nukareddy, P, Uusitalo, H, Aapola, U. Intraluminal deposits: A rare cause of glaucoma drainage implant total obstruction. Eur J Ophthalmol. 2023;33 (1):307-311. doi: 10.1177/11206721221100074. PubMed PMID:35575733 .
  11. Pelttari, S, Väärämäki, S, Vanakker, O, Verschuere, S, Uusitalo, H, Huhtala, H et al.. Various vascular malformations are prevalent in Finnish pseudoxanthoma elasticum (PXE) patients: a national registry study. Orphanet J Rare Dis. 2022;17 (1):185. doi: 10.1186/s13023-022-02341-6. PubMed PMID:35525997 PubMed Central PMC9077871.
  12. Purola, PKM, Nättinen, JE, Ojamo, MUI, Rissanen, HA, Gissler, M, Koskinen, SVP et al.. Prevalence and 11-Year Incidence of Cataract and Cataract Surgery and the Effects of Socio-Demographic and Lifestyle Factors. Clin Ophthalmol. 2022;16 :1183-1195. doi: 10.2147/OPTH.S355191. PubMed PMID:35480623 PubMed Central PMC9035455.
  13. Saramies, J, Koiranen, M, Auvinen, J, Uusitalo, H, Hussi, E, Becker, S et al.. A Natural History of Erectile Dysfunction in Elderly Men: A Population-Based, Twelve-Year Prospective Study. J Clin Med. 2022;11 (8):. doi: 10.3390/jcm11082146. PubMed PMID:35456238 PubMed Central PMC9029758.
  14. Bellenguez, C, Küçükali, F, Jansen, IE, Kleineidam, L, Moreno-Grau, S, Amin, N et al.. New insights into the genetic etiology of Alzheimer’s disease and related dementias. Nat Genet. 2022;54 (4):412-436. doi: 10.1038/s41588-022-01024-z. PubMed PMID:35379992 PubMed Central PMC9005347.
  15. Aapola, U, Nättinen, J, Suurkuukka, I, Tuomilehto, J, Keinänen-Kiukaanniemi, S, Saramies, J et al.. Ocular surface health of the Finnish elderly population. Acta Ophthalmol. 2022;100 (8):894-902. doi: 10.1111/aos.15130. PubMed PMID:35322930 PubMed Central PMC9790390.
  16. Tamlander, M, Mars, N, Pirinen, M, FinnGen, Widén, E, Ripatti, S et al.. Integration of questionnaire-based risk factors improves polygenic risk scores for human coronary heart disease and type 2 diabetes. Commun Biol. 2022;5 (1):158. doi: 10.1038/s42003-021-02996-0. PubMed PMID:35197564 PubMed Central PMC8866413.
  17. Nättinen, J, Aapola, U, Nukareddy, P, Uusitalo, H. Looking deeper into ocular surface health: an introduction to clinical tear proteomics analysis. Acta Ophthalmol. 2022;100 (5):486-498. doi: 10.1111/aos.15059. PubMed PMID:34750985 .
  18. Vaajanen, A, Purola, P, Ojamo, M, Gissler, M, Uusitalo, H. Changes in incidence and severity of visual impairment due to glaucoma during 40 years – a register-based study in Finland. Acta Ophthalmol. 2022;100 (5):534-540. doi: 10.1111/aos.15030. PubMed PMID:34595821 .
  19. Purola, PKM, Nättinen, JE, Parkkari, MM, Ojamo, MUI, Koskinen, SVP, Rissanen, HA et al.. Improving health-related quality of life in glaucoma during 11 years and its association with vision loss and treatment of the disease. Acta Ophthalmol. 2022;100 (1):e221-e232. doi: 10.1111/aos.14883. PubMed PMID:33955668 .

Search PubMed

2021

  1. Nättinen, J, Aapola, U, Nukareddy, P, Uusitalo, H. Looking deeper into ocular surface health: an introduction to clinical tear proteomics analysis. Acta Ophthalmol. 2022;100 (5):486-498. doi: 10.1111/aos.15059. PubMed PMID:34750985 .
  2. Mäkelä, E, Venesvirta, H, Ilves, M, Lylykangas, J, Rantanen, V, Uusitalo, H et al.. Electrically Induced Blink for the Prevention of Ocular Symptoms and Blurred Vision in Patients With Acute Facial Nerve Palsy. Ear Nose Throat J. 2021; :1455613211048576. doi: 10.1177/01455613211048576. PubMed PMID:34714168 .
  3. Saramies, J, Koiranen, M, Auvinen, J, Uusitalo, H, Hussi, E, Cederberg, H et al.. 22-year trends in dysglycemia and body mass index: A population-based cohort study in Savitaipale, Finland. Prim Care Diabetes. 2021;15 (6):977-984. doi: 10.1016/j.pcd.2021.09.010. PubMed PMID:34649826 .
  4. Vaajanen, A, Purola, P, Ojamo, M, Gissler, M, Uusitalo, H. Changes in incidence and severity of visual impairment due to glaucoma during 40 years – a register-based study in Finland. Acta Ophthalmol. 2022;100 (5):534-540. doi: 10.1111/aos.15030. PubMed PMID:34595821 .
  5. NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants. Lancet. 2021;398 (10304):957-980. doi: 10.1016/S0140-6736(21)01330-1. PubMed PMID:34450083 PubMed Central PMC8446938.
  6. Garifullin, A, Lensu, L, Uusitalo, H. Deep Bayesian baseline for segmenting diabetic retinopathy lesions: Advances and challenges. Comput Biol Med. 2021;136 :104725. doi: 10.1016/j.compbiomed.2021.104725. PubMed PMID:34399196 .
  7. Palomäki, A, FinnGen Rheumatology Clinical Expert Group, Palotie, A, Koskela, J, Eklund, KK, Pirinen, M et al.. Lifetime risk of rheumatoid arthritis-associated interstitial lung disease in mutation carriers. Ann Rheum Dis. 2021;80 (12):1530-1536. doi: 10.1136/annrheumdis-2021-220698. PubMed PMID:34344703 PubMed Central PMC8600604.
  8. Zekavat, SM, Lin, SH, Bick, AG, Liu, A, Paruchuri, K, Wang, C et al.. Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection. Nat Med. 2021;27 (6):1012-1024. doi: 10.1038/s41591-021-01371-0. PubMed PMID:34099924 PubMed Central PMC8245201.
  9. Liuska, PJ, Lemmelä, S, Havulinna, AS, Kaarniranta, K, Uusitalo, H, Laivuori, H et al.. Association of the MYOC p.(Gln368Ter) Variant With Glaucoma in a Finnish Population. JAMA Ophthalmol. 2021;139 (7):762-768. doi: 10.1001/jamaophthalmol.2021.1610. PubMed PMID:34081096 PubMed Central PMC8176385.
  10. Purola, PKM, Nättinen, JE, Parkkari, MM, Ojamo, MUI, Koskinen, SVP, Rissanen, HA et al.. Improving health-related quality of life in glaucoma during 11 years and its association with vision loss and treatment of the disease. Acta Ophthalmol. 2022;100 (1):e221-e232. doi: 10.1111/aos.14883. PubMed PMID:33955668 .
  11. Julku, H, Rouhinen, S, Huttunen, HJ, Lindberg, L, Liinamaa, J, Saarela, V et al.. Reduced evoked activity and cortical oscillations are correlated with anisometric amblyopia and impairment of visual acuity. Sci Rep. 2021;11 (1):8310. doi: 10.1038/s41598-021-87545-9. PubMed PMID:33859272 PubMed Central PMC8050307.
  12. Natarajan, P, Pampana, A, Graham, SE, Ruotsalainen, SE, Perry, JA, de Vries, PS et al.. Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices. Nat Commun. 2021;12 (1):2182. doi: 10.1038/s41467-021-22339-1. PubMed PMID:33846329 PubMed Central PMC8042019.
  13. Viljanen, A, Koskela, K, Koskela, H, Tuuminen, R, Uusitalo, H. One-year Results of Health-related and Vision-related Quality of Life After Clear Lens Extraction and Multifocal Intraocular Lens Implantation. Am J Ophthalmol. 2021;227 :240-244. doi: 10.1016/j.ajo.2021.03.023. PubMed PMID:33823159 .
  14. Purola, PKM, Nättinen, JE, Ojamo, MUI, Koskinen, SVP, Rissanen, HA, Sainio, PRJ et al.. Prevalence and 11-year incidence of common eye diseases and their relation to health-related quality of life, mental health, and visual impairment. Qual Life Res. 2021;30 (8):2311-2327. doi: 10.1007/s11136-021-02817-1. PubMed PMID:33755897 PubMed Central PMC8298234.
  15. NCD Risk Factor Collaboration (NCD-RisC). Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight. Elife. 2021;10 :. doi: 10.7554/eLife.60060. PubMed PMID:33685583 PubMed Central PMC7943191.
  16. Gharahkhani, P, Jorgenson, E, Hysi, P, Khawaja, AP, Pendergrass, S, Han, X et al.. Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries. Nat Commun. 2021;12 (1):1258. doi: 10.1038/s41467-020-20851-4. PubMed PMID:33627673 PubMed Central PMC7904932.
  17. Strausz, S, Kiiskinen, T, Broberg, M, Ruotsalainen, S, Koskela, J, Bachour, A et al.. Sleep apnoea is a risk factor for severe COVID-19. BMJ Open Respir Res. 2021;8 (1):. doi: 10.1136/bmjresp-2020-000845. PubMed PMID:33436406 PubMed Central PMC7804843.
  18. Ruotsalainen, SE, Partanen, JJ, Cichonska, A, Lin, J, Benner, C, Surakka, I et al.. An expanded analysis framework for multivariate GWAS connects inflammatory biomarkers to functional variants and disease. Eur J Hum Genet. 2021;29 (2):309-324. doi: 10.1038/s41431-020-00730-8. PubMed PMID:33110245 PubMed Central PMC7868371.
  19. Konstas, AG, Schmetterer, L, Katsanos, A, Hutnik, CML, Holló, G, Quaranta, L et al.. Dorzolamide/Timolol Fixed Combination: Learning from the Past and Looking Toward the Future. Adv Ther. 2021;38 (1):24-51. doi: 10.1007/s12325-020-01525-5. PubMed PMID:33108623 PubMed Central PMC7854404.
  20. Vaajanen, A, Nättinen, J, Aapola, U, Gielen, F, Uusitalo, H. The effect of successful trabeculectomy on the ocular surface and tear proteomics-a prospective cohort study with 1-year follow-up. Acta Ophthalmol. 2021;99 (2):160-170. doi: 10.1111/aos.14526. PubMed PMID:32643292 .

Search PubMed

2020

  1. Mars, N, Widén, E, Kerminen, S, Meretoja, T, Pirinen, M, Della Briotta Parolo, P et al.. The role of polygenic risk and susceptibility genes in breast cancer over the course of life. Nat Commun. 2020;11 (1):6383. doi: 10.1038/s41467-020-19966-5. PubMed PMID:33318493 PubMed Central PMC7736877.
  2. NCD Risk Factor Collaboration (NCD-RisC). Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants. Lancet. 2020;396 (10261):1511-1524. doi: 10.1016/S0140-6736(20)31859-6. PubMed PMID:33160572 PubMed Central PMC7658740.
  3. Ruotsalainen, SE, Partanen, JJ, Cichonska, A, Lin, J, Benner, C, Surakka, I et al.. An expanded analysis framework for multivariate GWAS connects inflammatory biomarkers to functional variants and disease. Eur J Hum Genet. 2021;29 (2):309-324. doi: 10.1038/s41431-020-00730-8. PubMed PMID:33110245 PubMed Central PMC7868371.
  4. Konstas, AG, Schmetterer, L, Katsanos, A, Hutnik, CML, Holló, G, Quaranta, L et al.. Dorzolamide/Timolol Fixed Combination: Learning from the Past and Looking Toward the Future. Adv Ther. 2021;38 (1):24-51. doi: 10.1007/s12325-020-01525-5. PubMed PMID:33108623 PubMed Central PMC7854404.
  5. Nättinen, J, Mäkinen, P, Aapola, U, Orsila, L, Pietilä, J, Uusitalo, H et al.. Early changes in tear film protein profiles after femtosecond LASIK surgery. Clin Proteomics. 2020;17 :36. doi: 10.1186/s12014-020-09303-9. PubMed PMID:33088244 PubMed Central PMC7574433.
  6. Bao, EL, Nandakumar, SK, Liao, X, Bick, AG, Karjalainen, J, Tabaka, M et al.. Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells. Nature. 2020;586 (7831):769-775. doi: 10.1038/s41586-020-2786-7. PubMed PMID:33057200 PubMed Central PMC7606745.
  7. Nättinen, J, Aapola, U, Jylhä, A, Vaajanen, A, Uusitalo, H. Comparison of Capillary and Schirmer Strip Tear Fluid Sampling Methods Using SWATH-MS Proteomics Approach. Transl Vis Sci Technol. 2020;9 (3):16. doi: 10.1167/tvst.9.3.16. PubMed PMID:32714642 PubMed Central PMC7351636.
  8. Hongisto, H, Dewing, JM, Christensen, DR, Scott, J, Cree, AJ, Nättinen, J et al.. In vitro stem cell modelling demonstrates a proof-of-concept for excess functional mutant TIMP3 as the cause of Sorsby fundus dystrophy. J Pathol. 2020;252 (2):138-150. doi: 10.1002/path.5506. PubMed PMID:32666594 .
  9. Vaajanen, A, Nättinen, J, Aapola, U, Gielen, F, Uusitalo, H. The effect of successful trabeculectomy on the ocular surface and tear proteomics-a prospective cohort study with 1-year follow-up. Acta Ophthalmol. 2021;99 (2):160-170. doi: 10.1111/aos.14526. PubMed PMID:32643292 .
  10. Tienaho, J, Karonen, M, Muilu-Mäkelä, R, Kaseva, J, de Pedro, N, Vicente, F et al.. Bioactive Properties of the Aqueous Extracts of Endophytic Fungi Associated with Scots Pine (Pinus sylvestris) Roots. Planta Med. 2020;86 (13-14):1009-1024. doi: 10.1055/a-1185-4437. PubMed PMID:32521558 .
  11. NCD Risk Factor Collaboration (NCD-RisC). Repositioning of the global epicentre of non-optimal cholesterol. Nature. 2020;582 (7810):73-77. doi: 10.1038/s41586-020-2338-1. PubMed PMID:32494083 PubMed Central PMC7332422.
  12. Kaarniranta, K, Uusitalo, H, Blasiak, J, Felszeghy, S, Kannan, R, Kauppinen, A et al.. Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration. Prog Retin Eye Res. 2020;79 :100858. doi: 10.1016/j.preteyeres.2020.100858. PubMed PMID:32298788 PubMed Central PMC7650008.
  13. Mars, N, Koskela, JT, Ripatti, P, Kiiskinen, TTJ, Havulinna, AS, Lindbohm, JV et al.. Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers. Nat Med. 2020;26 (4):549-557. doi: 10.1038/s41591-020-0800-0. PubMed PMID:32273609 .
  14. Karesvuo, P, Hakkala, L, Kaarniranta, K, Uusitalo, H, Ojamo, M, Tuuminen, R et al.. Correlation between the rate of intravitreal injections, use of aflibercept as a second-line treatment and visual impairment for wet AMD in Finland. Acta Ophthalmol. 2020;98 (5):472-476. doi: 10.1111/aos.14376. PubMed PMID:32096347 .
  15. Parkkari, M, Taipale, J, Uusitalo, H. Comparing glaucoma medications and general demographics in a sample of glaucoma patients treated in private practice with nationwide registry data in Finland. Acta Ophthalmol. 2020;98 (5):449-454. doi: 10.1111/aos.14338. PubMed PMID:31885212 .
  16. NCD Risk Factor Collaboration (NCD-RisC). National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: a pooled analysis of 458 population-based studies in Asian and Western countries. Int J Epidemiol. 2020;49 (1):173-192. doi: 10.1093/ije/dyz099. PubMed PMID:31321439 PubMed Central PMC7245049.

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2019

  1. Parkkari, M, Taipale, J, Uusitalo, H. Comparing glaucoma medications and general demographics in a sample of glaucoma patients treated in private practice with nationwide registry data in Finland. Acta Ophthalmol. 2019; :. doi: 10.1111/aos.14338. PubMed PMID:31885212 .
  2. Tabassum, R, Rämö, JT, Ripatti, P, Koskela, JT, Kurki, M, Karjalainen, J et al.. Genetic architecture of human plasma lipidome and its link to cardiovascular disease. Nat Commun. 2019;10 (1):4329. doi: 10.1038/s41467-019-11954-8. PubMed PMID:31551469 PubMed Central PMC6760179.
  3. Johansson, JK, Karema-Jokinen, VI, Hakanen, S, Jylhä, A, Uusitalo, H, Vihinen-Ranta, M et al.. Sodium channels enable fast electrical signaling and regulate phagocytosis in the retinal pigment epithelium. BMC Biol. 2019;17 (1):63. doi: 10.1186/s12915-019-0681-1. PubMed PMID:31412898 PubMed Central PMC6694495.
  4. Taipale, J, Mikhailova, A, Ojamo, M, Nättinen, J, Väätäinen, S, Gissler, M et al.. Low vision status and declining vision decrease Health-Related Quality of Life: Results from a nationwide 11-year follow-up study. Qual Life Res. 2019;28 (12):3225-3236. doi: 10.1007/s11136-019-02260-3. PubMed PMID:31401749 PubMed Central PMC6863947.
  5. Mäkinen, P, Huhtala, A, Pietilä, J, Nättinen, J, Rajala, T, Salmenhaara, K et al.. Patient satisfaction and self-reported dry eye symptoms in hyperopic patients treated with femtosecond laser in situ keratomileusis. Clin Ophthalmol. 2019;13 :741-754. doi: 10.2147/OPTH.S195991. PubMed PMID:31114152 PubMed Central PMC6487895.
  6. NCD Risk Factor Collaboration (NCD-RisC). Rising rural body-mass index is the main driver of the global obesity epidemic in adults. Nature. 2019;569 (7755):260-264. doi: 10.1038/s41586-019-1171-x. PubMed PMID:31068725 PubMed Central PMC6784868.
  7. Alarautalahti, V, Ragauskas, S, Hakkarainen, JJ, Uusitalo-Järvinen, H, Uusitalo, H, Hyttinen, J et al.. Viability of Mouse Retinal Explant Cultures Assessed by Preservation of Functionality and Morphology. Invest Ophthalmol Vis Sci. 2019;60 (6):1914-1927. doi: 10.1167/iovs.18-25156. PubMed PMID:31042799 .
  8. Nättinen, J, Jylhä, A, Aapola, U, Mäkinen, P, Beuerman, R, Pietilä, J et al.. Age-associated changes in human tear proteome. Clin Proteomics. 2019;16 :11. doi: 10.1186/s12014-019-9233-5. PubMed PMID:30976209 PubMed Central PMC6441198.

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2018

  1. Pietilä, J, Huhtala, A, Mäkinen, P, Nättinen, J, Rajala, T, Salmenhaara, K et al.. Uncorrected visual acuity, postoperative astigmatism, and dry eye symptoms are major determinants of patient satisfaction: a comparative, real-life study of femtosecond laser in situ keratomileusis and small incision lenticule extraction for myopia. Clin Ophthalmol. 2018;12 :1741-1755. doi: 10.2147/OPTH.S172894. PubMed PMID:30237694 PubMed Central PMC6136412.
  2. Huttunen, HJ, Palva, JM, Lindberg, L, Palva, S, Saarela, V, Karvonen, E et al.. Fluoxetine does not enhance the effect of perceptual learning on visual function in adults with amblyopia. Sci Rep. 2018;8 (1):12830. doi: 10.1038/s41598-018-31169-z. PubMed PMID:30150750 PubMed Central PMC6110780.
  3. Nättinen, J, Jylhä, A, Aapola, U, Parkkari, M, Mikhailova, A, Beuerman, RW et al.. Patient stratification in clinical glaucoma trials using the individual tear proteome. Sci Rep. 2018;8 (1):12038. doi: 10.1038/s41598-018-30369-x. PubMed PMID:30104599 PubMed Central PMC6089987.
  4. Jylhä, A, Nättinen, J, Aapola, U, Mikhailova, A, Nykter, M, Zhou, L et al.. Comparison of iTRAQ and SWATH in a clinical study with multiple time points. Clin Proteomics. 2018;15 :24. doi: 10.1186/s12014-018-9201-5. PubMed PMID:30069167 PubMed Central PMC6065059.
  5. Vähätupa, M, Nättinen, J, Jylhä, A, Aapola, U, Kataja, M, Kööbi, P et al.. SWATH-MS Proteomic Analysis of Oxygen-Induced Retinopathy Reveals Novel Potential Therapeutic Targets. Invest Ophthalmol Vis Sci. 2018;59 (8):3294-3306. doi: 10.1167/iovs.18-23831. PubMed PMID:30025079 .
  6. NCD Risk Factor Collaboration (NCD-RisC)
    . Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: a pooled analysis of 1018 population-based measurement studies with 88.6 million participants. Int J Epidemiol. 2018;47 (3):872-883i. doi: 10.1093/ije/dyy016. PubMed PMID:29579276 PubMed Central PMC6005056.
  7. Latonen, L, Afyounian, E, Jylhä, A, Nättinen, J, Aapola, U, Annala, M et al.. Integrative proteomics in prostate cancer uncovers robustness against genomic and transcriptomic aberrations during disease progression. Nat Commun. 2018;9 (1):1176. doi: 10.1038/s41467-018-03573-6. PubMed PMID:29563510 PubMed Central PMC5862881.
  8. Vähätupa, M, Cordova, ZM, Barker, H, Aittomäki, S, Uusitalo, H, Järvinen, TAH et al.. Furin deficiency in myeloid cells leads to attenuated revascularization in a mouse-model of oxygen-induced retinopathy. Exp Eye Res. 2018;166 :160-167. doi: 10.1016/j.exer.2017.10.013. PubMed PMID:29031855 .
  9. Nättinen, J, Jylhä, A, Aapola, U, Enríquez-de-Salamanca, A, Pinto-Fraga, J, López-Miguel, A et al.. Topical fluorometholone treatment and desiccating stress change inflammatory protein expression in tears. Ocul Surf. 2018;16 (1):84-92. doi: 10.1016/j.jtos.2017.09.003. PubMed PMID:28918083 .

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