Publications

2021

  1. Vaajanen, A, Purola, P, Ojamo, M, Gissler, M, Uusitalo, H. Changes in incidence and severity of visual impairment due to glaucoma during 40 years – a register-based study in Finland. Acta Ophthalmol. 2021; :. doi: 10.1111/aos.15030. PubMed PMID:34595821 .
  2. NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants. Lancet. 2021;398 (10304):957-980. doi: 10.1016/S0140-6736(21)01330-1. PubMed PMID:34450083 PubMed Central PMC8446938.
  3. Garifullin, A, Lensu, L, Uusitalo, H. Deep Bayesian baseline for segmenting diabetic retinopathy lesions: Advances and challenges. Comput Biol Med. 2021;136 :104725. doi: 10.1016/j.compbiomed.2021.104725. PubMed PMID:34399196 .
  4. Palomäki, A, FinnGen Rheumatology Clinical Expert Group, Palotie, A, Koskela, J, Eklund, KK, Pirinen, M et al.. Lifetime risk of rheumatoid arthritis-associated interstitial lung disease in MUC5B mutation carriers. Ann Rheum Dis. 2021; :. doi: 10.1136/annrheumdis-2021-220698. PubMed PMID:34344703 .
  5. Zekavat, SM, Lin, SH, Bick, AG, Liu, A, Paruchuri, K, Wang, C et al.. Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection. Nat Med. 2021;27 (6):1012-1024. doi: 10.1038/s41591-021-01371-0. PubMed PMID:34099924 PubMed Central PMC8245201.
  6. Liuska, PJ, Lemmelä, S, Havulinna, AS, Kaarniranta, K, Uusitalo, H, Laivuori, H et al.. Association of the MYOC p.(Gln368Ter) Variant With Glaucoma in a Finnish Population. JAMA Ophthalmol. 2021;139 (7):762-768. doi: 10.1001/jamaophthalmol.2021.1610. PubMed PMID:34081096 PubMed Central PMC8176385.
  7. Purola, PKM, Nättinen, JE, Parkkari, MM, Ojamo, MUI, Koskinen, SVP, Rissanen, HA et al.. Improving health-related quality of life in glaucoma during 11 years and its association with vision loss and treatment of the disease. Acta Ophthalmol. 2021; :. doi: 10.1111/aos.14883. PubMed PMID:33955668 .
  8. Julku, H, Rouhinen, S, Huttunen, HJ, Lindberg, L, Liinamaa, J, Saarela, V et al.. Reduced evoked activity and cortical oscillations are correlated with anisometric amblyopia and impairment of visual acuity. Sci Rep. 2021;11 (1):8310. doi: 10.1038/s41598-021-87545-9. PubMed PMID:33859272 PubMed Central PMC8050307.
  9. Natarajan, P, Pampana, A, Graham, SE, Ruotsalainen, SE, Perry, JA, de Vries, PS et al.. Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices. Nat Commun. 2021;12 (1):2182. doi: 10.1038/s41467-021-22339-1. PubMed PMID:33846329 PubMed Central PMC8042019.
  10. Viljanen, A, Koskela, K, Koskela, H, Tuuminen, R, Uusitalo, H. One-year Results of Health-related and Vision-related Quality of Life After Clear Lens Extraction and Multifocal Intraocular Lens Implantation. Am J Ophthalmol. 2021;227 :240-244. doi: 10.1016/j.ajo.2021.03.023. PubMed PMID:33823159 .
  11. Purola, PKM, Nättinen, JE, Ojamo, MUI, Koskinen, SVP, Rissanen, HA, Sainio, PRJ et al.. Prevalence and 11-year incidence of common eye diseases and their relation to health-related quality of life, mental health, and visual impairment. Qual Life Res. 2021;30 (8):2311-2327. doi: 10.1007/s11136-021-02817-1. PubMed PMID:33755897 PubMed Central PMC8298234.
  12. NCD Risk Factor Collaboration (NCD-RisC). Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight. Elife. 2021;10 :. doi: 10.7554/eLife.60060. PubMed PMID:33685583 PubMed Central PMC7943191.
  13. Gharahkhani, P, Jorgenson, E, Hysi, P, Khawaja, AP, Pendergrass, S, Han, X et al.. Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries. Nat Commun. 2021;12 (1):1258. doi: 10.1038/s41467-020-20851-4. PubMed PMID:33627673 PubMed Central PMC7904932.
  14. Strausz, S, Kiiskinen, T, Broberg, M, Ruotsalainen, S, Koskela, J, Bachour, A et al.. Sleep apnoea is a risk factor for severe COVID-19. BMJ Open Respir Res. 2021;8 (1):. doi: 10.1136/bmjresp-2020-000845. PubMed PMID:33436406 PubMed Central PMC7804843.
  15. Ruotsalainen, SE, Partanen, JJ, Cichonska, A, Lin, J, Benner, C, Surakka, I et al.. An expanded analysis framework for multivariate GWAS connects inflammatory biomarkers to functional variants and disease. Eur J Hum Genet. 2021;29 (2):309-324. doi: 10.1038/s41431-020-00730-8. PubMed PMID:33110245 PubMed Central PMC7868371.
  16. Konstas, AG, Schmetterer, L, Katsanos, A, Hutnik, CML, Holló, G, Quaranta, L et al.. Dorzolamide/Timolol Fixed Combination: Learning from the Past and Looking Toward the Future. Adv Ther. 2021;38 (1):24-51. doi: 10.1007/s12325-020-01525-5. PubMed PMID:33108623 PubMed Central PMC7854404.
  17. Vaajanen, A, Nättinen, J, Aapola, U, Gielen, F, Uusitalo, H. The effect of successful trabeculectomy on the ocular surface and tear proteomics-a prospective cohort study with 1-year follow-up. Acta Ophthalmol. 2021;99 (2):160-170. doi: 10.1111/aos.14526. PubMed PMID:32643292 .

Search PubMed

2020

  1. Mars, N, Widén, E, Kerminen, S, Meretoja, T, Pirinen, M, Della Briotta Parolo, P et al.. The role of polygenic risk and susceptibility genes in breast cancer over the course of life. Nat Commun. 2020;11 (1):6383. doi: 10.1038/s41467-020-19966-5. PubMed PMID:33318493 PubMed Central PMC7736877.
  2. NCD Risk Factor Collaboration (NCD-RisC). Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants. Lancet. 2020;396 (10261):1511-1524. doi: 10.1016/S0140-6736(20)31859-6. PubMed PMID:33160572 PubMed Central PMC7658740.
  3. Ruotsalainen, SE, Partanen, JJ, Cichonska, A, Lin, J, Benner, C, Surakka, I et al.. An expanded analysis framework for multivariate GWAS connects inflammatory biomarkers to functional variants and disease. Eur J Hum Genet. 2021;29 (2):309-324. doi: 10.1038/s41431-020-00730-8. PubMed PMID:33110245 PubMed Central PMC7868371.
  4. Konstas, AG, Schmetterer, L, Katsanos, A, Hutnik, CML, Holló, G, Quaranta, L et al.. Dorzolamide/Timolol Fixed Combination: Learning from the Past and Looking Toward the Future. Adv Ther. 2021;38 (1):24-51. doi: 10.1007/s12325-020-01525-5. PubMed PMID:33108623 PubMed Central PMC7854404.
  5. Nättinen, J, Mäkinen, P, Aapola, U, Orsila, L, Pietilä, J, Uusitalo, H et al.. Early changes in tear film protein profiles after femtosecond LASIK surgery. Clin Proteomics. 2020;17 :36. doi: 10.1186/s12014-020-09303-9. PubMed PMID:33088244 PubMed Central PMC7574433.
  6. Bao, EL, Nandakumar, SK, Liao, X, Bick, AG, Karjalainen, J, Tabaka, M et al.. Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells. Nature. 2020;586 (7831):769-775. doi: 10.1038/s41586-020-2786-7. PubMed PMID:33057200 PubMed Central PMC7606745.
  7. Nättinen, J, Aapola, U, Jylhä, A, Vaajanen, A, Uusitalo, H. Comparison of Capillary and Schirmer Strip Tear Fluid Sampling Methods Using SWATH-MS Proteomics Approach. Transl Vis Sci Technol. 2020;9 (3):16. doi: 10.1167/tvst.9.3.16. PubMed PMID:32714642 PubMed Central PMC7351636.
  8. Hongisto, H, Dewing, JM, Christensen, DR, Scott, J, Cree, AJ, Nättinen, J et al.. In vitro stem cell modelling demonstrates a proof-of-concept for excess functional mutant TIMP3 as the cause of Sorsby fundus dystrophy. J Pathol. 2020;252 (2):138-150. doi: 10.1002/path.5506. PubMed PMID:32666594 .
  9. Vaajanen, A, Nättinen, J, Aapola, U, Gielen, F, Uusitalo, H. The effect of successful trabeculectomy on the ocular surface and tear proteomics-a prospective cohort study with 1-year follow-up. Acta Ophthalmol. 2021;99 (2):160-170. doi: 10.1111/aos.14526. PubMed PMID:32643292 .
  10. Tienaho, J, Karonen, M, Muilu-Mäkelä, R, Kaseva, J, de Pedro, N, Vicente, F et al.. Bioactive Properties of the Aqueous Extracts of Endophytic Fungi Associated with Scots Pine (Pinus sylvestris) Roots. Planta Med. 2020;86 (13-14):1009-1024. doi: 10.1055/a-1185-4437. PubMed PMID:32521558 .
  11. NCD Risk Factor Collaboration (NCD-RisC). Repositioning of the global epicentre of non-optimal cholesterol. Nature. 2020;582 (7810):73-77. doi: 10.1038/s41586-020-2338-1. PubMed PMID:32494083 PubMed Central PMC7332422.
  12. Kaarniranta, K, Uusitalo, H, Blasiak, J, Felszeghy, S, Kannan, R, Kauppinen, A et al.. Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration. Prog Retin Eye Res. 2020;79 :100858. doi: 10.1016/j.preteyeres.2020.100858. PubMed PMID:32298788 PubMed Central PMC7650008.
  13. Karesvuo, P, Hakkala, L, Kaarniranta, K, Uusitalo, H, Ojamo, M, Tuuminen, R et al.. Correlation between the rate of intravitreal injections, use of aflibercept as a second-line treatment and visual impairment for wet AMD in Finland. Acta Ophthalmol. 2020; :. doi: 10.1111/aos.14376. PubMed PMID:32096347 .
  14. NCD Risk Factor Collaboration (NCD-RisC). National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: a pooled analysis of 458 population-based studies in Asian and Western countries. Int J Epidemiol. 2020;49 (1):173-192. doi: 10.1093/ije/dyz099. PubMed PMID:31321439 PubMed Central PMC7245049.

Search PubMed

2019

  1. Parkkari, M, Taipale, J, Uusitalo, H. Comparing glaucoma medications and general demographics in a sample of glaucoma patients treated in private practice with nationwide registry data in Finland. Acta Ophthalmol. 2019; :. doi: 10.1111/aos.14338. PubMed PMID:31885212 .
  2. Tabassum, R, Rämö, JT, Ripatti, P, Koskela, JT, Kurki, M, Karjalainen, J et al.. Genetic architecture of human plasma lipidome and its link to cardiovascular disease. Nat Commun. 2019;10 (1):4329. doi: 10.1038/s41467-019-11954-8. PubMed PMID:31551469 PubMed Central PMC6760179.
  3. Johansson, JK, Karema-Jokinen, VI, Hakanen, S, Jylhä, A, Uusitalo, H, Vihinen-Ranta, M et al.. Sodium channels enable fast electrical signaling and regulate phagocytosis in the retinal pigment epithelium. BMC Biol. 2019;17 (1):63. doi: 10.1186/s12915-019-0681-1. PubMed PMID:31412898 PubMed Central PMC6694495.
  4. Taipale, J, Mikhailova, A, Ojamo, M, Nättinen, J, Väätäinen, S, Gissler, M et al.. Low vision status and declining vision decrease Health-Related Quality of Life: Results from a nationwide 11-year follow-up study. Qual Life Res. 2019;28 (12):3225-3236. doi: 10.1007/s11136-019-02260-3. PubMed PMID:31401749 PubMed Central PMC6863947.
  5. Mäkinen, P, Huhtala, A, Pietilä, J, Nättinen, J, Rajala, T, Salmenhaara, K et al.. Patient satisfaction and self-reported dry eye symptoms in hyperopic patients treated with femtosecond laser in situ keratomileusis. Clin Ophthalmol. 2019;13 :741-754. doi: 10.2147/OPTH.S195991. PubMed PMID:31114152 PubMed Central PMC6487895.
  6. NCD Risk Factor Collaboration (NCD-RisC). Rising rural body-mass index is the main driver of the global obesity epidemic in adults. Nature. 2019;569 (7755):260-264. doi: 10.1038/s41586-019-1171-x. PubMed PMID:31068725 PubMed Central PMC6784868.
  7. Alarautalahti, V, Ragauskas, S, Hakkarainen, JJ, Uusitalo-Järvinen, H, Uusitalo, H, Hyttinen, J et al.. Viability of Mouse Retinal Explant Cultures Assessed by Preservation of Functionality and Morphology. Invest Ophthalmol Vis Sci. 2019;60 (6):1914-1927. doi: 10.1167/iovs.18-25156. PubMed PMID:31042799 .
  8. Nättinen, J, Jylhä, A, Aapola, U, Mäkinen, P, Beuerman, R, Pietilä, J et al.. Age-associated changes in human tear proteome. Clin Proteomics. 2019;16 :11. doi: 10.1186/s12014-019-9233-5. PubMed PMID:30976209 PubMed Central PMC6441198.

Search PubMed

2018

  1. Pietilä, J, Huhtala, A, Mäkinen, P, Nättinen, J, Rajala, T, Salmenhaara, K et al.. Uncorrected visual acuity, postoperative astigmatism, and dry eye symptoms are major determinants of patient satisfaction: a comparative, real-life study of femtosecond laser in situ keratomileusis and small incision lenticule extraction for myopia. Clin Ophthalmol. 2018;12 :1741-1755. doi: 10.2147/OPTH.S172894. PubMed PMID:30237694 PubMed Central PMC6136412.
  2. Huttunen, HJ, Palva, JM, Lindberg, L, Palva, S, Saarela, V, Karvonen, E et al.. Fluoxetine does not enhance the effect of perceptual learning on visual function in adults with amblyopia. Sci Rep. 2018;8 (1):12830. doi: 10.1038/s41598-018-31169-z. PubMed PMID:30150750 PubMed Central PMC6110780.
  3. Nättinen, J, Jylhä, A, Aapola, U, Parkkari, M, Mikhailova, A, Beuerman, RW et al.. Patient stratification in clinical glaucoma trials using the individual tear proteome. Sci Rep. 2018;8 (1):12038. doi: 10.1038/s41598-018-30369-x. PubMed PMID:30104599 PubMed Central PMC6089987.
  4. Jylhä, A, Nättinen, J, Aapola, U, Mikhailova, A, Nykter, M, Zhou, L et al.. Comparison of iTRAQ and SWATH in a clinical study with multiple time points. Clin Proteomics. 2018;15 :24. doi: 10.1186/s12014-018-9201-5. PubMed PMID:30069167 PubMed Central PMC6065059.
  5. Vähätupa, M, Nättinen, J, Jylhä, A, Aapola, U, Kataja, M, Kööbi, P et al.. SWATH-MS Proteomic Analysis of Oxygen-Induced Retinopathy Reveals Novel Potential Therapeutic Targets. Invest Ophthalmol Vis Sci. 2018;59 (8):3294-3306. doi: 10.1167/iovs.18-23831. PubMed PMID:30025079 .
  6. NCD Risk Factor Collaboration (NCD-RisC)
    . Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: a pooled analysis of 1018 population-based measurement studies with 88.6 million participants. Int J Epidemiol. 2018;47 (3):872-883i. doi: 10.1093/ije/dyy016. PubMed PMID:29579276 PubMed Central PMC6005056.
  7. Latonen, L, Afyounian, E, Jylhä, A, Nättinen, J, Aapola, U, Annala, M et al.. Integrative proteomics in prostate cancer uncovers robustness against genomic and transcriptomic aberrations during disease progression. Nat Commun. 2018;9 (1):1176. doi: 10.1038/s41467-018-03573-6. PubMed PMID:29563510 PubMed Central PMC5862881.
  8. Vähätupa, M, Cordova, ZM, Barker, H, Aittomäki, S, Uusitalo, H, Järvinen, TAH et al.. Furin deficiency in myeloid cells leads to attenuated revascularization in a mouse-model of oxygen-induced retinopathy. Exp Eye Res. 2018;166 :160-167. doi: 10.1016/j.exer.2017.10.013. PubMed PMID:29031855 .
  9. Nättinen, J, Jylhä, A, Aapola, U, Enríquez-de-Salamanca, A, Pinto-Fraga, J, López-Miguel, A et al.. Topical fluorometholone treatment and desiccating stress change inflammatory protein expression in tears. Ocul Surf. 2018;16 (1):84-92. doi: 10.1016/j.jtos.2017.09.003. PubMed PMID:28918083 .

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